{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:54:20Z","timestamp":1793379260000,"version":"4.5.0"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10306-8","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:34:25Z","timestamp":1738647265000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cellular signalling of melatonin and its role in metabolic disorders"],"prefix":"10.1007","volume":"52","author":[{"given":"Snehasis","family":"Tripathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrat Kumar","family":"Bhattamisra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"10306_CR1","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1007\/s10571-023-01324-w","volume":"43","author":"SB Ahmad","year":"2023","unstructured":"Ahmad SB, Ali A, Bilal M et al (2023) Melatonin and health: insights of melatonin action, biological functions, and associated disorders. Cell Mol Neurobiol 43:2437\u20132458","journal-title":"Cell Mol Neurobiol"},{"key":"10306_CR2","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/1831821a0","volume":"183","author":"AB Lerner","year":"1959","unstructured":"Lerner AB, Case JD, Mori W, Wright MR (1959) Melatonin in peripheral nerve. Nature 183:1821. https:\/\/doi.org\/10.1038\/1831821a0","journal-title":"Nature"},{"key":"10306_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.pneurobio.2008.04.001","volume":"85","author":"SR Pandi-Perumal","year":"2008","unstructured":"Pandi-Perumal SR, Trakht I, Srinivasan V et al (2008) Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol 85:335\u2013353","journal-title":"Prog Neurobiol"},{"key":"10306_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tem.2007.10.007","volume":"19","author":"A Slominski","year":"2008","unstructured":"Slominski A, Tobin DJ, Zmijewski MA et al (2008) Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab 19:17\u201324","journal-title":"Trends Endocrinol Metab"},{"key":"10306_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12528","volume":"65","author":"T Quintela","year":"2018","unstructured":"Quintela T, Gon\u00e7alves I, Silva M et al (2018) Choroid plexus is an additional source of melatonin in the brain. J Pineal Res 65:e12528. https:\/\/doi.org\/10.1111\/jpi.12528","journal-title":"J Pineal Res"},{"key":"10306_CR6","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","volume":"74","author":"RJ Reiter","year":"2017","unstructured":"Reiter RJ, Rosales-Corral S, Tan DX et al (2017) Melatonin as a mitochondria-targeted antioxidant: one of evolution\u2019s best ideas. Cell Mol Life Sci 74:3863\u20133881","journal-title":"Cell Mol Life Sci"},{"key":"10306_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","volume":"51","author":"A Galano","year":"2011","unstructured":"Galano A, Tan DX, Reiter RJ (2011) Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 51:1\u201316","journal-title":"J Pineal Res"},{"key":"10306_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11154-009-9117-5","volume":"10","author":"A Korkmaz","year":"2009","unstructured":"Korkmaz A, Topal T, Tan DX, Reiter RJ (2009) Role of melatonin in metabolic regulation. Rev Endocr Metab Disord 10:261\u2013270","journal-title":"Rev Endocr Metab Disord"},{"key":"10306_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","volume":"42","author":"DX Tan","year":"2007","unstructured":"Tan DX, Manchester LC, Terron MP et al (2007) One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 42:28\u201342","journal-title":"J Pineal Res"},{"key":"10306_CR10","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1600-0625.2008.00767.x","volume":"17","author":"TW Fischer","year":"2008","unstructured":"Fischer TW, Slominski A, Zmijewski MA et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol 17:713\u2013730","journal-title":"Exp Dermatol"},{"key":"10306_CR11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0014-5793(96)00437-1","volume":"386","author":"SM Reppert","year":"1996","unstructured":"Reppert SM, Weaver DR, Ebisawa T et al (1996) Cloning of a melatonin-related receptor from human pituitary. FEBS Lett 386:219\u2013224. https:\/\/doi.org\/10.1016\/0014-5793(96)00437-1","journal-title":"FEBS Lett"},{"key":"10306_CR12","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1096\/fasebj.12.12.1211","volume":"12","author":"ML Dubocovich","year":"1998","unstructured":"Dubocovich ML, Yun K, Al-Ghoul WM et al (1998) Selective MT 2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J 12:1211\u20131220. https:\/\/doi.org\/10.1096\/fasebj.12.12.1211","journal-title":"FASEB J"},{"key":"10306_CR13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","volume":"309","author":"C Von Gall","year":"2002","unstructured":"Von Gall C, Stehle JH, Weaver DR (2002) Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res 309:151\u2013162","journal-title":"Cell Tissue Res"},{"key":"10306_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2148-8-105","volume":"8","author":"L Dufourny","year":"2008","unstructured":"Dufourny L, Levasseur A, Migaud M et al (2008) GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals. BMC Evol Biol 8:1\u20134. https:\/\/doi.org\/10.1186\/1471-2148-8-105","journal-title":"BMC Evol Biol"},{"key":"10306_CR15","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1038\/sj.emboj.7601193","volume":"25","author":"A Levoye","year":"2006","unstructured":"Levoye A, Dam J, Ayoub MA et al (2006) The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J 25:3012\u20133023. https:\/\/doi.org\/10.1038\/sj.emboj.7601193","journal-title":"EMBO J"},{"key":"10306_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","volume":"60","author":"C Ekmekcioglu","year":"2006","unstructured":"Ekmekcioglu C (2006) Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 60:97\u2013108","journal-title":"Biomed Pharmacother"},{"key":"10306_CR17","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/S0006-2952(01)00615-3","volume":"61","author":"O Nosjean","year":"2001","unstructured":"Nosjean O, Nicolas JP, Klupsch F et al (2001) Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3\/QR2. Tissue distribution of MT3\/QR2. Biochem Pharmacol 61:1369\u20131379. https:\/\/doi.org\/10.1016\/S0006-2952(01)00615-3","journal-title":"Biochem Pharmacol"},{"key":"10306_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1159\/000125245","volume":"50","author":"PJ Morgan","year":"1989","unstructured":"Morgan PJ, Lawson W, Davidson G, Howell HE (1989) Guanine nucleotide regulate the affinity of melatonin receptors on the ovine pars tuberalis. Neuroendocrinology 50:359\u2013362. https:\/\/doi.org\/10.1159\/000125245","journal-title":"Neuroendocrinology"},{"key":"10306_CR19","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1210\/endo-85-4-674","volume":"85","author":"K Abe","year":"1969","unstructured":"Abe K, Robison GA, Liddle GW et al (1969) Role of cyclic AMP in mediating the effects of MSH, norepinephrine, and melatonin on frog skin color. Endocrinology 85:674\u2013682. https:\/\/doi.org\/10.1210\/endo-85-4-674","journal-title":"Endocrinology"},{"key":"10306_CR20","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1210\/endo.135.1.8013371","volume":"135","author":"S Capsoni","year":"1994","unstructured":"Capsoni S, Viswanathan M, De Oliveira AM, Saavedra JM (1994) Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis. Endocrinology 135:373\u2013378. https:\/\/doi.org\/10.1210\/endo.135.1.8013371","journal-title":"Endocrinology"},{"key":"10306_CR21","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0024-3205(03)00098-5","volume":"72","author":"PA Witt-Enderby","year":"2003","unstructured":"Witt-Enderby PA, Bennett J, Jarzynka MJ et al (2003) Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci 72:2183\u20132198","journal-title":"Life Sci"},{"key":"10306_CR22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0898-6568(01)00240-6","volume":"14","author":"ASL Chan","year":"2002","unstructured":"Chan ASL, Lai FPL, Lo RKH et al (2002) Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins. Cell Signal 14:249\u2013257. https:\/\/doi.org\/10.1016\/S0898-6568(01)00240-6","journal-title":"Cell Signal"},{"key":"10306_CR23","doi-asserted-by":"publisher","first-page":"21522","DOI":"10.1074\/jbc.M200729200","volume":"277","author":"MA Ayoub","year":"2002","unstructured":"Ayoub MA, Couturier C, Lucas-Meunier E et al (2002) Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 277:21522\u201321528. https:\/\/doi.org\/10.1074\/jbc.M200729200","journal-title":"J Biol Chem"},{"key":"10306_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1124\/mol.104.000398","volume":"66","author":"MA Ayoub","year":"2004","unstructured":"Ayoub MA, Levoye A, Delagrange P, Jockers R (2004) Preferential formation of MT1\/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT 2 homodimers. Mol Pharmacol 66:312\u2013321. https:\/\/doi.org\/10.1124\/mol.104.000398","journal-title":"Mol Pharmacol"},{"key":"10306_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12641","volume":"68","author":"M Chen","year":"2020","unstructured":"Chen M, Cecon E, Karamitri A et al (2020) Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi\/o and Gq\/11 proteins. J Pineal Res 68:e12641. https:\/\/doi.org\/10.1111\/jpi.12641","journal-title":"J Pineal Res"},{"key":"10306_CR26","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1541-7786.MCR-16-0158","volume":"14","author":"L Mao","year":"2016","unstructured":"Mao L, Summers W, Xiang S et al (2016) Melatonin represses metastasis in Her2-postive human breast cancer cells by suppressing RSK2 expression. Mol Cancer Res 14:1159\u20131169. https:\/\/doi.org\/10.1158\/1541-7786.MCR-16-0158","journal-title":"Mol Cancer Res"},{"key":"10306_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3892\/mmr.2014.2753","volume":"11","author":"X Cheng","year":"2015","unstructured":"Cheng X, Wan Y, Xu Y et al (2015) Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits. Mol Med Rep 11:99\u2013104. https:\/\/doi.org\/10.3892\/mmr.2014.2753","journal-title":"Mol Med Rep"},{"key":"10306_CR28","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1530\/EJE-21-0314","volume":"185","author":"ZH Li","year":"2021","unstructured":"Li ZH, Zhang PD (2021) Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study. Eur J Endocrinol 185:765\u2013774","journal-title":"Eur J Endocrinol"},{"key":"10306_CR29","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23806","volume":"14","author":"P Bhandari","year":"2022","unstructured":"Bhandari P, Sapra A, Ajmeri MS et al (2022) Nonalcoholic fatty liver disease: could it be the next medical tsunami? Cureus 14:e23806. https:\/\/doi.org\/10.7759\/cureus.23806","journal-title":"Cureus"},{"key":"10306_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1600-079X.2009.00736.x","volume":"48","author":"LD Ji","year":"2010","unstructured":"Ji LD, Xu J, Wu DD et al (2010) Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. J Pineal Res 48:133\u2013141. https:\/\/doi.org\/10.1111\/j.1600-079X.2009.00736.x","journal-title":"J Pineal Res"},{"key":"10306_CR31","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","volume":"23","author":"T Tuomi","year":"2016","unstructured":"Tuomi T, Nagorny CLF, Singh P et al (2016) Increased melatonin signaling is a risk factor for type 2 diabetes. Cell Metab 23:1067\u20131077. https:\/\/doi.org\/10.1016\/j.cmet.2016.04.009","journal-title":"Cell Metab"},{"key":"10306_CR32","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00109-017-1508-6","volume":"95","author":"M Shigeto","year":"2017","unstructured":"Shigeto M, Cha CY, Rorsman P, Kaku K (2017) A role of PLC\/PKC-dependent pathway in GLP-1-stimulated insulin secretion. J Mol Med 95:361\u2013368","journal-title":"J Mol Med"},{"key":"10306_CR33","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1210\/endo.141.3.7351","volume":"141","author":"H Zemkov\u00e1","year":"2000","unstructured":"Zemkov\u00e1 H, Van\u011b\u010dek J (2000) Differences in gonadotropin-releasing hormone-induced calcium signaling between melatonin-sensitive and melatonin-insensitive neonatal rat gonadotrophs. Endocrinology 141:1017\u20131026. https:\/\/doi.org\/10.1210\/endo.141.3.7351","journal-title":"Endocrinology"},{"key":"10306_CR34","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1600-079X.2005.00253.x","volume":"39","author":"AG Bach","year":"2005","unstructured":"Bach AG, Wolgast S, M\u00fchlbauer E, Peschke E (2005) Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells. J Pineal Res 39:316\u2013323. https:\/\/doi.org\/10.1111\/j.1600-079X.2005.00253.x","journal-title":"J Pineal Res"},{"key":"10306_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev-physiol-030212-183754","volume":"75","author":"P Rorsman","year":"2013","unstructured":"Rorsman P, Braun M (2013) Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol 75:155\u2013179","journal-title":"Annu Rev Physiol"},{"key":"10306_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1600-079X.2007.00519.x","volume":"44","author":"E Peschke","year":"2008","unstructured":"Peschke E (2008) Melatonin, endocrine pancreas and diabetes. J Pineal Res 44:26\u201340","journal-title":"J Pineal Res"},{"key":"10306_CR37","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/ars.2017.7380","volume":"30","author":"FU Rahman","year":"2019","unstructured":"Rahman FU, Park DR, Joe Y et al (2019) Critical roles of carbon monoxide and nitric oxide in Ca 2+ signaling for insulin secretion in pancreatic islets. Antioxid Redox Signal 30:560\u2013576. https:\/\/doi.org\/10.1089\/ars.2017.7380","journal-title":"Antioxid Redox Signal"},{"key":"10306_CR38","doi-asserted-by":"publisher","first-page":"16624","DOI":"10.1073\/pnas.1213790109","volume":"109","author":"KJ Hurt","year":"2012","unstructured":"Hurt KJ, Sezen SF, Lagoda GF et al (2012) Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A 109:16624\u201316629. https:\/\/doi.org\/10.1073\/pnas.1213790109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10306_CR39","doi-asserted-by":"publisher","first-page":"14307","DOI":"10.1074\/jbc.M311103200","volume":"279","author":"GA Rameau","year":"2004","unstructured":"Rameau GA, Chiu LY, Ziff EB (2004) Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-Methyl-D-aspartate receptor. J Biol Chem 279:14307\u201314314. https:\/\/doi.org\/10.1074\/jbc.M311103200","journal-title":"J Biol Chem"},{"key":"10306_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134962","volume":"10","author":"DR Park","year":"2015","unstructured":"Park DR, Shawl AI, Ha TG et al (2015) Arginine thiazolidine carboxylate stimulates insulin secretion through production of Ca2+-mobilizing second messengers NAADP and cADPR in pancreatic islets. PLoS ONE 10:e0134962. https:\/\/doi.org\/10.1371\/journal.pone.0134962","journal-title":"PLoS ONE"},{"key":"10306_CR41","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190744","author":"B Huang","year":"2019","unstructured":"Huang B, Wang YK, Qin LY et al (2019) A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20190744"},{"key":"10306_CR42","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ng.3437","volume":"47","author":"KJ Gaulton","year":"2015","unstructured":"Gaulton KJ, Ferreira T, Lee Y et al (2015) Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 47:1415\u20131425. https:\/\/doi.org\/10.1038\/ng.3437","journal-title":"Nat Genet"},{"key":"10306_CR43","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.2337\/db08-1660","volume":"58","author":"T Spars\u00f8","year":"2009","unstructured":"Spars\u00f8 T, Bonnefond A, Andersson E et al (2009) G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 58:1450\u20131456. https:\/\/doi.org\/10.2337\/db08-1660","journal-title":"Diabetes"},{"key":"10306_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.888319","volume":"9","author":"M Tobeiha","year":"2022","unstructured":"Tobeiha M, Jafari A, Fadaei S et al (2022) Evidence for the benefits of melatonin in cardiovascular disease. Front Cardiovasc Med 9:888319","journal-title":"Front Cardiovasc Med"},{"key":"10306_CR45","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.bbadis.2017.11.023","volume":"1864","author":"LM Yu","year":"2018","unstructured":"Yu LM, Cheng DW, Dong X et al (2018) Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation. Biochim Biophys Acta Mol Basis Dis 1864:563\u2013578. https:\/\/doi.org\/10.1016\/j.bbadis.2017.11.023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10306_CR46","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1111\/bph.12959","volume":"172","author":"J Inserte","year":"2015","unstructured":"Inserte J, Garcia-Dorado D (2015) The cGMP\/PKG pathway as a common mediator of cardioprotection: translatability and mechanism. Br J Pharmacol 172:1996\u20132009","journal-title":"Br J Pharmacol"},{"key":"10306_CR47","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1152\/ajpheart.00666.2014.-Diabetes","volume":"308","author":"Z Shi","year":"2015","unstructured":"Shi Z, Fu F, Yu L et al (2015) Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. Am J Physiol Heart Circ Physiol 308:281\u2013290. https:\/\/doi.org\/10.1152\/ajpheart.00666.2014.-Diabetes","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10306_CR48","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1161\/CIRCHEARTFAILURE.113.000575","volume":"6","author":"Q Kong","year":"2013","unstructured":"Kong Q, Blanton RM (2013) Protein Kinase G i and heart failure shifting focus from vascular unloading to direct myocardial antiremodeling effects. Circ Heart Fail 6:1268\u20131283. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.113.000575","journal-title":"Circ Heart Fail"},{"key":"10306_CR49","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1152\/ajpheart.00100.2009.-Sildenafil","volume":"296","author":"A Das","year":"2009","unstructured":"Das A, Salloum FN, Xi L, Rao YJ, Kukreja RC (2009) ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol 296:1236\u20131243. https:\/\/doi.org\/10.1152\/ajpheart.00100.2009.-Sildenafil","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10306_CR50","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.cellsig.2016.06.012","volume":"28","author":"AW Holt","year":"2016","unstructured":"Holt AW, Martin DN, Shaver PR et al (2016) Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation. Cell Signal 28:1364\u20131379. https:\/\/doi.org\/10.1016\/j.cellsig.2016.06.012","journal-title":"Cell Signal"},{"key":"10306_CR51","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/ejhf.711","volume":"19","author":"C M\u00e1ty\u00e1s","year":"2017","unstructured":"M\u00e1ty\u00e1s C, N\u00e9meth BT, Ol\u00e1h A et al (2017) Prevention of the development of heart failure with preserved ejection fraction by the phosphodiesterase-5A inhibitor vardenafil in rats with type 2 diabetes. Eur J Heart Fail 19:326\u2013336. https:\/\/doi.org\/10.1002\/ejhf.711","journal-title":"Eur J Heart Fail"},{"key":"10306_CR52","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1124\/jpet.110.174482","volume":"336","author":"RR Tunstall","year":"2011","unstructured":"Tunstall RR, Shukla P, Grazul-Bilska A et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336:127\u2013133. https:\/\/doi.org\/10.1124\/jpet.110.174482","journal-title":"J Pharmacol Exp Ther"},{"key":"10306_CR53","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.tips.2005.06.006","volume":"26","author":"JA Boutin","year":"2005","unstructured":"Boutin JA, Audinot V, Ferry G, Delagrange P (2005) Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci 26:412\u2013419","journal-title":"Trends Pharmacol Sci"},{"key":"10306_CR54","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12378","volume":"62","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Xu L, Ding S et al (2017) Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-\u03b1 in diabetic cardiomyopathy. J Pineal Res 62:e12378. https:\/\/doi.org\/10.1111\/jpi.12378","journal-title":"J Pineal Res"},{"key":"10306_CR55","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1007\/s10495-017-1378-y","volume":"22","author":"L Yu","year":"2017","unstructured":"Yu L, Li S, Tang X et al (2017) Diallyl trisulfide ameliorates myocardial ischemia\u2013reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation. Apoptosis 22:942\u2013954. https:\/\/doi.org\/10.1007\/s10495-017-1378-y","journal-title":"Apoptosis"},{"key":"10306_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/792639","volume":"2011","author":"Y Son","year":"2011","unstructured":"Son Y, Cheong Y-K, Kim N-H et al (2011) Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J Signal Transduct 2011:1\u20136. https:\/\/doi.org\/10.1155\/2011\/792639","journal-title":"J Signal Transduct"},{"key":"10306_CR57","doi-asserted-by":"publisher","first-page":"7580731","DOI":"10.1155\/2016\/7580731","volume":"2016","author":"K Suchal","year":"2016","unstructured":"Suchal K, Malik S, Gamad N et al (2016) Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury. Oxid Med Cell Longev 2016:7580731. https:\/\/doi.org\/10.1155\/2016\/7580731","journal-title":"Oxid Med Cell Longev"},{"key":"10306_CR58","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1093\/abbs\/gmw079","volume":"48","author":"X Yan","year":"2016","unstructured":"Yan X, Xun M, Li J et al (2016) Activation of Na+\/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217. Acta Biochim Biophys Sin (Shanghai) 48:883\u2013893. https:\/\/doi.org\/10.1093\/abbs\/gmw079","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10306_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12682","volume":"69","author":"Y Li","year":"2020","unstructured":"Li Y, Ma J, Yao K et al (2020) Circadian rhythms and obesity: Timekeeping governs lipid metabolism. J Pineal Res 69:e12682","journal-title":"J Pineal Res"},{"key":"10306_CR60","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jpi.12137","volume":"56","author":"J Cipolla-Neto","year":"2014","unstructured":"Cipolla-Neto J, Amaral FG, Afeche SC et al (2014) Melatonin, energy metabolism, and obesity: a review. J Pineal Res 56:371\u2013381","journal-title":"J Pineal Res"},{"key":"10306_CR61","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3389\/fendo.2019.00750","volume":"10","author":"T da Silva","year":"2019","unstructured":"da Silva T, de Farias M, Cruz MM, Cavalcante R, da Cunha S et al (2019) Melatonin supplementation decreases hypertrophic obesity and inflammation induced by high-fat diet in mice. Front Endocrinol (Lausanne) 10:750. https:\/\/doi.org\/10.3389\/fendo.2019.00750","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10306_CR62","first-page":"72","volume":"9","author":"DO Ivanov","year":"2020","unstructured":"Ivanov DO, Evsyukova II, Mazzoccoli G et al (2020) The role of prenatal melatonin in the regulation of childhood obesity. Biology (Basel) 9:72","journal-title":"Biology (Basel)"},{"key":"10306_CR63","doi-asserted-by":"publisher","first-page":"4927403","DOI":"10.1155\/2020\/4927403","volume":"2020","author":"W Liu","year":"2020","unstructured":"Liu W, Zhang Y, Chen Q et al (2020) Melatonin alleviates glucose and lipid metabolism disorders in Guinea pigs caused by different artificial light rhythms. J Diabetes Res 2020:4927403. https:\/\/doi.org\/10.1155\/2020\/4927403","journal-title":"J Diabetes Res"},{"key":"10306_CR64","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1080\/07420528.2021.2014517","volume":"39","author":"Y Choi","year":"2022","unstructured":"Choi Y, Nakamura Y, Akazawa N et al (2022) Effects of nocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover trial. Chronobiol Int 39:602\u2013612. https:\/\/doi.org\/10.1080\/07420528.2021.2014517","journal-title":"Chronobiol Int"},{"key":"10306_CR65","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3390\/cells9020489","volume":"9","author":"F Hong","year":"2020","unstructured":"Hong F, Pan S, Xu P et al (2020) Melatonin orchestrates lipid homeostasis through the hepatointestinal circadian clock and microbiota during constant light exposure. Cells 9:489. https:\/\/doi.org\/10.3390\/cells9020489","journal-title":"Cells"},{"key":"10306_CR66","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12383","volume":"62","author":"Z Liu","year":"2017","unstructured":"Liu Z, Gan L, Luo D, Sun C (2017) Melatonin promotes circadian rhythm-induced proliferation through Clock\/histone deacetylase 3\/c-Myc interaction in mouse adipose tissue. J Pineal Res 62:e12383. https:\/\/doi.org\/10.1111\/jpi.12383","journal-title":"J Pineal Res"},{"key":"10306_CR67","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.2174\/09298673113209990114","volume":"20","author":"L Shi","year":"2013","unstructured":"Shi L, Li N (2013) Melatonin and hypothalamic-pituitary-gonadal axis. Curr Med Chem 20:2017\u20132031","journal-title":"Curr Med Chem"},{"key":"10306_CR68","doi-asserted-by":"publisher","DOI":"10.1111\/and.14242","volume":"54","author":"CA Oladele","year":"2022","unstructured":"Oladele CA, Akintayo CO, Badejogbin OC et al (2022) Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high-fat diet-induced obesity in male Wistar rats. Andrologia 54:e14242. https:\/\/doi.org\/10.1111\/and.14242","journal-title":"Andrologia"},{"key":"10306_CR69","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/MED.0000000000000511","volume":"26","author":"J Mills","year":"2019","unstructured":"Mills J, Kuohung W (2019) Impact of circadian rhythms on female reproduction and infertility treatment success. Curr Opin Endocrinol Diabetes Obes 26:317\u2013321","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10306_CR70","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1039\/C4FO00317A","volume":"5","author":"M Navarro-Alarc\u00f3n","year":"2014","unstructured":"Navarro-Alarc\u00f3n M, Ruiz-Ojeda FJ, Blanca-Herrera RM et al (2014) Melatonin and metabolic regulation: A review. Food Funct 5:2806\u20132832","journal-title":"Food Funct"},{"key":"10306_CR71","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/BF03168221","volume":"60","author":"J Barrenetxe","year":"2004","unstructured":"Barrenetxe J, Delagrange P, Mart\u00ednez JA (2004) Physiological and metabolic functions of melatonin. J Physiol Biochem 60:61\u201372","journal-title":"J Physiol Biochem"},{"key":"10306_CR72","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12448","volume":"64","author":"W Ren","year":"2018","unstructured":"Ren W, Wang P, Yan J et al (2018) Melatonin alleviates weanling stress in mice: involvement of intestinal microbiota. J Pineal Res 64:e12448. https:\/\/doi.org\/10.1111\/jpi.12448","journal-title":"J Pineal Res"},{"key":"10306_CR73","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1017\/S0007114519001466","volume":"122","author":"A Yildirim","year":"2019","unstructured":"Yildirim A, Arabacl Tamer S, Sahin D et al (2019) The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats. Br J Nutr 122:841\u2013855. https:\/\/doi.org\/10.1017\/S0007114519001466","journal-title":"Br J Nutr"},{"key":"10306_CR74","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.jcmgh.2021.06.024","volume":"12","author":"B Rong","year":"2021","unstructured":"Rong B, Wu Q, Reiter RJ, Sun C (2021) The mechanism of oral melatonin ameliorates intestinal and adipose lipid dysmetabolism through reducing escherichia coli-derived lipopolysaccharide. Cell Mol Gastroenterol Hepatol 12:1643\u20131667. https:\/\/doi.org\/10.1016\/j.jcmgh.2021.06.024","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10306_CR75","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/obr.12499","volume":"18","author":"MP St-Onge","year":"2017","unstructured":"St-Onge MP (2017) Sleep\u2013obesity relation: underlying mechanisms and consequences for treatment. Obes Rev 18:34\u201339","journal-title":"Obes Rev"},{"key":"10306_CR76","first-page":"854","volume":"61","author":"S Huysmans","year":"2019","unstructured":"Huysmans S, De Hert M, Desplenter F (2019) Melatonine en slaapstoornissen: literatuuroverzicht en toetsing aan de psychiatrische praktijk. Tijdschr Psychiatr 61:854\u2013861","journal-title":"Tijdschr Psychiatr"},{"key":"10306_CR77","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/MCP.0000000000000522","volume":"24","author":"RL Riha","year":"2018","unstructured":"Riha RL (2018) The use and misuse of exogenous melatonin in the treatment of sleep disorders. Curr Opin Pulm Med 24:543\u2013548","journal-title":"Curr Opin Pulm Med"},{"key":"10306_CR78","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1111\/bph.14116","volume":"175","author":"N Zisapel","year":"2018","unstructured":"Zisapel N (2018) New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol 175:3190\u20133199","journal-title":"Br J Pharmacol"},{"key":"10306_CR79","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12498","volume":"65","author":"R Sharma","year":"2018","unstructured":"Sharma R, Sahota P, Thakkar MM (2018) Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus. J Pineal Res 65:e12498. https:\/\/doi.org\/10.1111\/jpi.12498","journal-title":"J Pineal Res"},{"key":"10306_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113598","volume":"417","author":"V Suriagandhi","year":"2022","unstructured":"Suriagandhi V, Nachiappan V (2022) Protective effects of melatonin against obesity-induced by leptin resistance. Behav Brain Res 417:113598","journal-title":"Behav Brain Res"},{"key":"10306_CR81","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12574","volume":"67","author":"T Gao","year":"2019","unstructured":"Gao T, Wang Z, Dong Y et al (2019) Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice. J Pineal Res 67:e12574. https:\/\/doi.org\/10.1111\/jpi.12574","journal-title":"J Pineal Res"},{"key":"10306_CR82","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.3390\/nu13103629","volume":"13","author":"M Gombert","year":"2021","unstructured":"Gombert M, Martin-Carbonell V, Pin-Arboledas G et al (2021) Melatonin levels in children with obesity are associated with metabolic risk and inflammatory parameters. Nutrients 13:3629. https:\/\/doi.org\/10.3390\/nu13103629","journal-title":"Nutrients"},{"key":"10306_CR83","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1021\/acs.jmedchem.0c00627","volume":"64","author":"MA Ferreira","year":"2021","unstructured":"Ferreira MA, Azevedo H, Mascarello A et al (2021) Discovery of ACH-000143: a novel potent and peripherally preferred melatonin receptor agonist that reduces liver triglycerides and steatosis in diet-induced obese rats. J Med Chem 64:1904\u20131929. https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00627","journal-title":"J Med Chem"},{"key":"10306_CR84","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuropharm.2004.09.007","volume":"48","author":"K Kato","year":"2005","unstructured":"Kato K, Hirai K, Nishiyama K et al (2005) Neurochemical properties of ramelteon (TAK-375), a selective MT 1\/MT2 receptor agonist. Neuropharmacology 48:301\u2013310. https:\/\/doi.org\/10.1016\/j.neuropharm.2004.09.007","journal-title":"Neuropharmacology"},{"key":"10306_CR85","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1177\/0091270005283461","volume":"46","author":"A Karim","year":"2006","unstructured":"Karim A, Tolbert D, Cao C (2006) Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia. J Clin Pharmacol 46:140\u2013148. https:\/\/doi.org\/10.1177\/0091270005283461","journal-title":"J Clin Pharmacol"},{"key":"10306_CR86","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00004850-200209000-00004","volume":"17","author":"H L\u00f4o","year":"2002","unstructured":"L\u00f4o H, Hale A, D\u2019haenen H (2002) Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int Clin Psychopharmacol 17:239\u2013247. https:\/\/doi.org\/10.1097\/00004850-200209000-00004","journal-title":"Int Clin Psychopharmacol"},{"key":"10306_CR87","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1124\/jpet.103.051797","volume":"306","author":"MJ Millan","year":"2003","unstructured":"Millan MJ, Gobert A, Lejeune F et al (2003) The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306:954\u2013964. https:\/\/doi.org\/10.1124\/jpet.103.051797","journal-title":"J Pharmacol Exp Ther"},{"key":"10306_CR88","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1017\/S1461145707007754","volume":"10","author":"MAQ Salva","year":"2007","unstructured":"Salva MAQ, Vanier B, Laredo J et al (2007) Major depressive disorder, sleep EEG and agomelatine: An open-label study. Int J Neuropsychopharmacol 10:691\u2013696. https:\/\/doi.org\/10.1017\/S1461145707007754","journal-title":"Int J Neuropsychopharmacol"},{"key":"10306_CR89","doi-asserted-by":"publisher","unstructured":"Partonen T (2023) Medication effects. Encyclopedia of Sleep and Circadian Rhythms: Volume 1\u20136, Second Edition 755\u2013760. https:\/\/doi.org\/10.1016\/B978-0-12-822963-7.00150-X","DOI":"10.1016\/B978-0-12-822963-7.00150-X"},{"key":"10306_CR90","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1081\/CBI-120014108","volume":"19","author":"T Nickelsen","year":"2002","unstructured":"Nickelsen T, Samel A, Vejvoda M et al (2002) Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9H time shift: results of a placebo-controlled trial. Chronobiol Int 19:915\u2013936. https:\/\/doi.org\/10.1081\/CBI-120014108","journal-title":"Chronobiol Int"},{"key":"10306_CR91","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neulet.2009.04.005","volume":"457","author":"SP Fisher","year":"2009","unstructured":"Fisher SP, Sugden D (2009) Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. Neurosci Lett 457:93\u201396. https:\/\/doi.org\/10.1016\/j.neulet.2009.04.005","journal-title":"Neurosci Lett"},{"key":"10306_CR92","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/01.j.pain.0000460311.71572.5f","volume":"156","author":"M Lopez-Canul","year":"2015","unstructured":"Lopez-Canul M, Palazzo E, Dominguez-Lopez S et al (2015) Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain 156:305\u2013317. https:\/\/doi.org\/10.1097\/01.j.pain.0000460311.71572.5f","journal-title":"Pain"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10306-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10306-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10306-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:36:20Z","timestamp":1766853380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10306-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10306"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10306-8","relation":{"references":[{"id-type":"doi","id":"10.1042\/BSR20190744","asserted-by":"subject"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"193"}}