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Consequently,\n                    <jats:italic>Plasmodium yoelii<\/jats:italic>\n                    , a rodent malaria parasite, has become an invaluable model for studying the malaria parasite\u2019s complex biology, particularly host-parasite interactions and drug resistance mechanisms. Originating from African rodents,\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    presents unique genetic diversity, mirroring critical aspects of human malaria and allowing for detailed research on the parasite\u2019s pre-erythrocytic and erythrocytic stages. This review introduces a novel perspective by comprehensively examining\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    from multiple angles, including its origin, genetic composition, and contributions to vaccine development and drug efficacy studies. It highlights the significance of\n                    <jats:italic>P. yoelii,<\/jats:italic>\n                    revealing new insights into immune evasion, pathogenesis, and disease severity, which are critical for developing future malaria interventions. Furthermore, this review addresses the challenges associated with\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    as a model, such as differences in host immune responses between rodents and humans. Despite these hurdles, the research using\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    offers promising directions for combating malaria. This novel synthesis of\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    studies underscores its essential role in advancing malaria research, particularly in understanding drug resistance and uncovering potential therapeutic and vaccine targets.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s11033-025-10318-4","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:54:59Z","timestamp":1738752899000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plasmodium yoelii as a model for malaria: insights into pathogenesis, drug resistance, and vaccine development"],"prefix":"10.1007","volume":"52","author":[{"given":"Oluwatobi","family":"Otun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"Achilonu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"10318_CR1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.medcle.2020.05.024","volume":"155","author":"R Varo","year":"2020","unstructured":"Varo R, Chaccour C, Bassat Q (2020) Update on malaria. 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