{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:24:50Z","timestamp":1780532690731,"version":"3.54.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10334-4","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:59:48Z","timestamp":1741924788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of curcumin on cyclosporine A-induced oxidative stress, autophagy, and apoptosis in rat heart"],"prefix":"10.1007","volume":"52","author":[{"given":"Roya","family":"Naderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Seyhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Shirpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-5456","authenticated-orcid":false,"given":"Adele","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Eyvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"10334_CR1","doi-asserted-by":"crossref","first-page":"230386","DOI":"10.1155\/2012\/230386","volume":"2012","author":"D Tedesco","year":"2012","unstructured":"Tedesco D, Haragsim L (2012) Cyclosporine: a review. J Transplantation 2012:230386","journal-title":"J Transplantation"},{"issue":"1\u20132","key":"10334_CR2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tox.2007.06.096","volume":"239","author":"Y Selcoki","year":"2007","unstructured":"Selcoki Y, Uz E, Bayrak R, Sahin S, Kaya A, Uz B et al (2007) The protective effect of erdosteine against cyclosporine A-induced cardiotoxicity in rats. Toxicology 239(1\u20132):53\u201359","journal-title":"Toxicology"},{"issue":"1","key":"10334_CR3","first-page":"52","volume":"66","author":"J Tang","year":"2011","unstructured":"Tang J, Wang G, Liu Y, Fu Y, Chi J, Zhu Y et al (2011) Cyclosporin A induces cardiomyocyte injury through calcium-sensing receptor-mediated calcium overload. Pharmazie 66(1):52\u201357","journal-title":"Pharmazie"},{"key":"10334_CR4","doi-asserted-by":"crossref","unstructured":"Nourmohammadi K (2022) Cyclosporine A-induces cardiac remodeling through TGF-\u03b2\/Smad3\/miR-29 signaling pathway and gene expression alteration of miR-30b-5p\/CaMKII\u03b4 isoforms pathway. Alleviated effect of moderate exercises","DOI":"10.21203\/rs.3.rs-1839964\/v1"},{"issue":"2\u20133","key":"10334_CR5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-5793(03)00898-6","volume":"552","author":"R Rezzani","year":"2003","unstructured":"Rezzani R, Rodella L, Dessy C, Daneau G, Bianchi R, Feron O (2003) Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium. FEBS Lett 552(2\u20133):125\u2013129","journal-title":"FEBS Lett"},{"issue":"6","key":"10334_CR6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1742-7843.2008.00313.x","volume":"103","author":"U Ebru","year":"2008","unstructured":"Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH et al (2008) Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol 103(6):574\u2013580","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10334_CR7","doi-asserted-by":"crossref","first-page":"747991","DOI":"10.3389\/fphar.2021.747991","volume":"12","author":"M Wan","year":"2021","unstructured":"Wan M, Huang L, Liu J, Liu F, Chen G, Ni H et al (2021) Cyclosporine a induces Cardiac Developmental toxicity in zebrafish by Up-Regulation of wnt signaling and oxidative stress. Front Pharmacol 12:747991","journal-title":"Front Pharmacol"},{"issue":"6","key":"10334_CR8","doi-asserted-by":"crossref","first-page":"L1005","DOI":"10.1152\/ajplung.2000.279.6.L1005","volume":"279","author":"VJ Thannickal","year":"2000","unstructured":"Thannickal VJ, Fanburg BL (2000) Reactive oxygen species in cell signaling. Am J Physiology-Lung Cell Mol Physiol 279(6):L1005\u2013L28","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"issue":"2","key":"10334_CR9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bst0290345","volume":"29","author":"J Hancock","year":"2001","unstructured":"Hancock J, Desikan R, Neill S (2001) Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 29(2):345\u2013349","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"10334_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2003.11.001","volume":"567","author":"MD Evans","year":"2004","unstructured":"Evans MD, Dizdaroglu M, Cooke MS (2004) Oxidative DNA damage and disease: induction, repair and significance. Mutat Research\/Reviews Mutat Res 567(1):1\u201361","journal-title":"Mutat Research\/Reviews Mutat Res"},{"issue":"1","key":"10334_CR11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.biophys.28.1.101","volume":"28","author":"CD Mol","year":"1999","unstructured":"Mol CD, Parikh SS, Putnam CD, Lo TP, Tainer JA (1999) DNA repair mechanisms for the recognition and removal of damaged DNA bases. Annu Rev BioPhys BioMol Struct 28(1):101\u2013128","journal-title":"Annu Rev BioPhys BioMol Struct"},{"issue":"10","key":"10334_CR12","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1089\/ars.2015.6508","volume":"24","author":"A Di Minno","year":"2016","unstructured":"Di Minno A, Turnu L, Porro B, Squellerio I, Cavalca V, Tremoli E et al (2016) 8-Hydroxy-2-deoxyguanosine levels and cardiovascular disease: a systematic review and meta-analysis of the literature. Antioxid Redox Signal 24(10):548\u2013555","journal-title":"Antioxid Redox Signal"},{"key":"10334_CR13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00395-011-0190-z","volume":"106","author":"A Sirker","year":"2011","unstructured":"Sirker A, Zhang M, Shah AM (2011) NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Res Cardiol 106:735\u2013747","journal-title":"Basic Res Cardiol"},{"key":"10334_CR14","doi-asserted-by":"crossref","unstructured":"El-Benna J, Dang PM-C, Gougerot-Pocidalo M-A (eds) (2008) Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Seminars in immunopathology. Springer","DOI":"10.1007\/s00281-008-0118-3"},{"issue":"3","key":"10334_CR15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","volume":"4","author":"JD Lambeth","year":"2004","unstructured":"Lambeth JD (2004) NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4(3):181\u2013189","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10334_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2007.04.021","volume":"43","author":"F Qin","year":"2007","unstructured":"Qin F, Simeone M, Patel R (2007) Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med 43(2):271\u2013281","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10334_CR17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1196\/annals.1331.015","volume":"1031","author":"M Jackson","year":"2004","unstructured":"Jackson M, Khassaf M, Vasilaki A, McArdle F, McArdle A (2004) Vitamin E and the oxidative stress of exercise. Ann N Y Acad Sci 1031(1):158\u2013168","journal-title":"Ann N Y Acad Sci"},{"key":"10334_CR18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1023\/A:1015549725819","volume":"67","author":"N Gusev","year":"2002","unstructured":"Gusev N, Bogatcheva N, Marston S (2002) Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins. Biochem (Moscow) 67:511\u2013519","journal-title":"Biochem (Moscow)"},{"issue":"4","key":"10334_CR19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0008-6363(01)00354-6","volume":"51","author":"DS Latchman","year":"2001","unstructured":"Latchman DS (2001) Heat shock proteins and cardiac protection. Cardiovascular Res 51(4):637\u2013646","journal-title":"Cardiovascular Res"},{"issue":"2","key":"10334_CR20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/pro.3725","volume":"29","author":"Q Liu","year":"2020","unstructured":"Liu Q, Liang C, Zhou L (2020) Structural and functional analysis of the Hsp70\/Hsp40 chaperone system. Protein Sci 29(2):378\u2013390","journal-title":"Protein Sci"},{"issue":"13","key":"10334_CR21","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1523\/JNEUROSCI.23-13-05789.2003","volume":"23","author":"Z Batulan","year":"2003","unstructured":"Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J et al (2003) High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci 23(13):5789\u20135798","journal-title":"J Neurosci"},{"issue":"8","key":"10334_CR22","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3109\/02656730903213366","volume":"25","author":"K-I Tanaka","year":"2009","unstructured":"Tanaka K-I, Mizushima T (2009) Protective role of HSF1 and HSP70 against gastrointestinal diseases. Int J Hyperth 25(8):668\u2013676","journal-title":"Int J Hyperth"},{"key":"10334_CR23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exer.2015.03.020","volume":"134","author":"HL Chandler","year":"2015","unstructured":"Chandler HL, Gervais KJ, Lutz EA, Curto EM, Matusow RB, Wilkie DA et al (2015) Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death. Exp Eye Res 134:63\u201372","journal-title":"Exp Eye Res"},{"key":"10334_CR24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-pharmtox-010716-104936","volume":"57","author":"E Morel","year":"2017","unstructured":"Morel E, Mehrpour M, Botti J, Dupont N, Hama\u00ef A, Nascimbeni AC et al (2017) Autophagy: a druggable process. Annu Rev Pharmacol Toxicol 57:375\u2013398","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10334_CR25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcell.2018.00137","volume":"6","author":"MB Menon","year":"2018","unstructured":"Menon MB, Dhamija S (2018) Beclin 1 phosphorylation\u2013at the center of autophagy regulation. Front cell Dev Biology 6:137","journal-title":"Front cell Dev Biology"},{"issue":"3","key":"10334_CR26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.2011.05648.x","volume":"39","author":"SC Gupta","year":"2012","unstructured":"Gupta SC, Patchva S, Koh W, Aggarwal BB (2012) Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 39(3):283\u2013299","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10334_CR27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2013.07.007","volume":"65","author":"Y Yang","year":"2013","unstructured":"Yang Y, Duan W, Lin Y, Yi W, Liang Z, Yan J et al (2013) SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. Free Radic Biol Med 65:667\u2013679","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"10334_CR28","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.archoralbio.2012.04.005","volume":"57","author":"JY Kim","year":"2012","unstructured":"Kim JY, Cho TJ, Woo BH, Choi KU, Lee CH, Ryu MH et al (2012) Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. Arch Oral Biol 57(8):1018\u20131025","journal-title":"Arch Oral Biol"},{"key":"10334_CR29","unstructured":"Hakhoe TS, Hakhoe TY, Health NI (1997) The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology"},{"issue":"4","key":"10334_CR30","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1349-7006.2011.02198.x","volume":"103","author":"W Zhuang","year":"2012","unstructured":"Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q et al (2012) Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy. Cancer Sci 103(4):684\u2013690","journal-title":"Cancer Sci"},{"issue":"4","key":"10334_CR31","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/biof.1830","volume":"48","author":"S Roshan-Milani","year":"2022","unstructured":"Roshan-Milani S, Sattari P, Ghaderi\u2010Pakdel F, Naderi R (2022) miR\u201023b\/Table 3\/NF\u2010\u03baB\/p53 axis is involved in hippocampus injury induced by cerebral ischemia\u2013reperfusion in rats: the protective effect of chlorogenic acid. BioFactors 48(4):908\u2013917","journal-title":"BioFactors"},{"issue":"4","key":"10334_CR32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15171\/jhp.2018.33","volume":"7","author":"N Boroumand","year":"2018","unstructured":"Boroumand N, Samarghandian S, Hashemy SI (2018) Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J Herbmed Pharmacol 7(4):211\u2013219","journal-title":"J Herbmed Pharmacol"},{"issue":"4","key":"10334_CR33","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/13880209.2012.742116","volume":"51","author":"C Yang","year":"2013","unstructured":"Yang C, Wu K, Li S-H, You Q (2013) Protective effect of curcumin against cardiac dysfunction in sepsis rats. Pharm Biol 51(4):482\u2013487","journal-title":"Pharm Biol"},{"key":"10334_CR34","doi-asserted-by":"crossref","first-page":"109180","DOI":"10.1016\/j.cbi.2020.109180","volume":"327","author":"AM Ghazipour","year":"2020","unstructured":"Ghazipour AM, Shirpoor A, Ghiasi R, Pourheydar B, Khalaji N, Naderi R (2020) Cyclosporine A induces testicular injury via mitochondrial apoptotic pathway by regulation of mir-34a and sirt-1 in male rats: the rescue effect of curcumin. Chemico-Biol Interact 327:109180","journal-title":"Chemico-Biol Interact"},{"issue":"11","key":"10334_CR35","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1016\/S0021-9258(17)40330-9","volume":"252","author":"JD Corbin","year":"1977","unstructured":"Corbin JD, Sugden P, Lincoln TM, Keely S (1977) Compartmentalization of adenosine 3\u2019: 5\u2019-monophosphate and adenosine 3\u2019: 5\u2019-monophosphate-dependent protein kinase in heart tissue. J Biol Chem 252(11):3854\u20133861","journal-title":"J Biol Chem"},{"issue":"9","key":"10334_CR36","doi-asserted-by":"crossref","first-page":"e0135988","DOI":"10.1371\/journal.pone.0135988","volume":"10","author":"ME Kabir","year":"2015","unstructured":"Kabir ME, Singh H, Lu R, Olde B, Leeb-Lundberg LF, Bopassa JC (2015) G protein-coupled estrogen receptor 1 mediates acute estrogen-induced cardioprotection via MEK\/ERK\/GSK-3\u03b2 pathway after ischemia\/reperfusion. PLoS ONE 10(9):e0135988","journal-title":"PLoS ONE"},{"issue":"4","key":"10334_CR37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/0748233712456065","volume":"30","author":"T Sagiroglu","year":"2014","unstructured":"Sagiroglu T, Kanter M, Yagci MA, Sezer A, Erboga M (2014) Protective effect of curcumin on cyclosporin A-induced endothelial dysfunction, antioxidant capacity, and oxidative damage. Toxicol Ind Health 30(4):316\u2013327","journal-title":"Toxicol Ind Health"},{"issue":"9","key":"10334_CR38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1034\/j.1600-6143.2002.20902.x","volume":"2","author":"LW Miller","year":"2002","unstructured":"Miller LW (2002) Cardiovascular toxicities of immunosuppressive agents. Am J Transplant 2(9):807\u2013818","journal-title":"Am J Transplant"},{"issue":"2","key":"10334_CR39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.proghi.2004.04.001","volume":"39","author":"R Rezzani","year":"2004","unstructured":"Rezzani R (2004) Cyclosporine A and adverse effects on organs: histochemical studies. Prog Histochem Cytochem 39(2):85\u2013128","journal-title":"Prog Histochem Cytochem"},{"key":"10334_CR40","first-page":"N34","volume":"19","author":"G Porter","year":"1998","unstructured":"Porter G, Norton T, Bennett W, Troponin T (1998) A predictor of death in chronic haemodialysis patients. Eur Heart J 19:N34\u2013N37","journal-title":"Eur Heart J"},{"key":"10334_CR41","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.fct.2018.06.054","volume":"118","author":"Q Wu","year":"2018","unstructured":"Wu Q, Wang X, Nepovimova E, Wang Y, Yang H, Kuca K (2018) Mechanism of cyclosporine A nephrotoxicity: oxidative stress, autophagy, and signalings. Food Chem Toxicology: Int J Published Br Industrial Biol Res Association 118:889\u2013907","journal-title":"Food Chem Toxicology: Int J Published Br Industrial Biol Res Association"},{"issue":"1","key":"10334_CR42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jcp.10216","volume":"195","author":"S Florio","year":"2003","unstructured":"Florio S, Ciarcia R, Crispino L, Pagnini U, Ruocco A, Kumar C et al (2003) Hydrocortisone has a protective effect on CyclosporinA-induced cardiotoxicity. J Cell Physiol 195(1):21\u201326","journal-title":"J Cell Physiol"},{"key":"10334_CR43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.freeradbiomed.2013.03.017","volume":"61","author":"F Correa","year":"2013","unstructured":"Correa F, Buelna-Chontal M, Hern\u00e1ndez-Res\u00e9ndiz S, Garc\u00eda-Ni\u00f1o WR, Rold\u00e1n FJ, Soto V et al (2013) Curcumin maintains cardiac and mitochondrial function in chronic kidney disease. Free Radic Biol Med 61:119\u2013129","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10334_CR44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/cbf.1623","volume":"28","author":"V Tanwar","year":"2010","unstructured":"Tanwar V, Sachdeva J, Kishore K, Mittal R, Nag TC, Ray R et al (2010) Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Cell Biochem Funct 28(1):74\u201382","journal-title":"Cell Biochem Funct"},{"issue":"1\u20133","key":"10334_CR45","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejphar.2009.06.014","volume":"616","author":"K Sompamit","year":"2009","unstructured":"Sompamit K, Kukongviriyapan U, Nakmareong S, Pannangpetch P, Kukongviriyapan V (2009) Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. Eur J Pharmacol 616(1\u20133):192\u2013199","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10334_CR46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/CEJ.0b013e328341017a","volume":"20","author":"M Roy","year":"2011","unstructured":"Roy M, Sinha D, Mukherjee S, Biswas J (2011) Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev 20(2):123\u2013131","journal-title":"Eur J Cancer Prev"},{"issue":"3","key":"10334_CR47","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejps.2012.04.018","volume":"47","author":"V Soetikno","year":"2012","unstructured":"Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Mito S, Harima M et al (2012) Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sciences: Official J Eur Federation Pharm Sci 47(3):604\u2013614","journal-title":"Eur J Pharm Sciences: Official J Eur Federation Pharm Sci"},{"key":"10334_CR48","doi-asserted-by":"crossref","first-page":"134368","DOI":"10.1016\/j.neulet.2019.134368","volume":"709","author":"J Dowell","year":"2019","unstructured":"Dowell J, Elser BA, Schroeder RE, Stevens HE (2019) Cellular stress mechanisms of prenatal maternal stress: heat shock factors and oxidative stress. Neurosci Lett 709:134368","journal-title":"Neurosci Lett"},{"issue":"6","key":"10334_CR49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/sj.bjp.0704908","volume":"137","author":"HW Chen","year":"2002","unstructured":"Chen HW, Chien CT, Yu SL, Lee YT, Chen WJ (2002) Cyclosporine a regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70. Br J Pharmacol 137(6):771\u2013781","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10334_CR50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1379\/CSC-265.1","volume":"12","author":"S Guo","year":"2007","unstructured":"Guo S, Wharton W, Moseley P, Shi H (2007) Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress Chaperones 12(3):245","journal-title":"Cell Stress Chaperones"},{"issue":"4","key":"10334_CR51","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12192-012-0399-2","volume":"18","author":"ZM Jenei","year":"2013","unstructured":"Jenei ZM, Sz\u00e9plaki G, Merkely B, Kar\u00e1di I, Zima E, Proh\u00e1szka Z (2013) Persistently elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker in post-cardiac-arrest patients. Cell Stress Chaperones 18(4):447\u2013454","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"10334_CR52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/iub.1274","volume":"66","author":"D Kennedy","year":"2014","unstructured":"Kennedy D, J\u00e4ger R, Mosser DD, Samali A (2014) Regulation of apoptosis by heat shock proteins. IUBMB Life 66(5):327\u2013338","journal-title":"IUBMB Life"},{"key":"10334_CR53","doi-asserted-by":"crossref","unstructured":"Sklifasovskaya AP, Blagonravov M, Ryabinina A, Goryachev V, Syatkin S, Chibisov S et al (2023) The role of heat shock proteins in the pathogenesis of heart failure (review). Int J Mol Med.;52(5)","DOI":"10.3892\/ijmm.2023.5309"},{"issue":"4","key":"10334_CR54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/1074248412438102","volume":"17","author":"CW Jeong","year":"2012","unstructured":"Jeong CW, Yoo KY, Lee SH, Jeong HJ, Lee CS, Kim SJ (2012) Curcumin protects against regional myocardial ischemia\/reperfusion injury through activation of RISK\/GSK-3\u03b2 and inhibition of p38 MAPK and JNK. J Cardiovasc Pharmacol Therap 17(4):387\u2013394","journal-title":"J Cardiovasc Pharmacol Therap"},{"key":"10334_CR55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biochi.2018.02.017","volume":"148","author":"J Chi","year":"2018","unstructured":"Chi J, Wang L, Zhang X, Fu Y, Liu Y, Chen W et al (2018) Cyclosporin A induces autophagy in cardiac fibroblasts through the NRP-2\/WDFY-1 axis. Biochimie 148:55\u201362","journal-title":"Biochimie"},{"issue":"6","key":"10334_CR56","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.3892\/mmr.2015.3322","volume":"11","author":"Z Huang","year":"2015","unstructured":"Huang Z, Ye B, Dai Z, Wu X, Lu Z, Shan P et al (2015) Curcumin inhibits autophagy and apoptosis in hypoxia\/reoxygenation-induced myocytes. Mol Med Rep 11(6):4678\u20134684","journal-title":"Mol Med Rep"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10334-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10334-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10334-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:32:55Z","timestamp":1766853175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10334-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10334"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10334-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments followed the guidelines of the \u201cInstitutional Guide for the Care and Use of Laboratory Animals.\u201d Further, our experiments were accepted by the local ethics committee (code No: IR.GUMS.REC.1399.088).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"310"}}