{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:23:36Z","timestamp":1790771016049,"version":"4.1.0"},"reference-count":134,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10477-4","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:51:07Z","timestamp":1744008667000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The interleukin gene landscape: understanding its influence on inflammatory mechanisms in apical periodontitis"],"prefix":"10.1007","volume":"52","author":[{"given":"Tuqa Z.","family":"Omran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Salem Obaid Al","family":"Jasmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawthar Mahdi","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammr Kareem Rashid","family":"Ghareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Ali","family":"Alsailawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Mudhafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"issue":"1","key":"10477_CR1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","volume":"9","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L (2024) Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Therapy 9(1):211","journal-title":"Signal Transduct Target Therapy"},{"issue":"3","key":"10477_CR2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4103\/MJBL.MJBL_1306_23","volume":"21","author":"NA Oudah","year":"2024","unstructured":"Oudah NA, Ghareeb AKR, Abd Kelkawi AH, Oudah MA (2024) Assessment of the binding Immunoglobulin protein, IL-1\u03b2, and some hematological indices in patients with urinary tract infections. Med J Babylon 21(3):579\u2013584","journal-title":"Med J Babylon"},{"issue":"1","key":"10477_CR3","first-page":"12","volume":"14","author":"K Wieczorkiewicz","year":"2024","unstructured":"Wieczorkiewicz K, Jarz\u0105bek A, Bakinowska E, Kie\u0142bowski K, Pawlik A (2024) Microbial dynamics in endodontic Pathology\u2014From bacterial infection to therapeutic Interventions\u2014A. Narrative Rev Pathogens 14(1):12","journal-title":"Narrative Rev Pathogens"},{"issue":"8","key":"10477_CR4","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3390\/microorganisms12081518","volume":"12","author":"A Teofani","year":"2024","unstructured":"Teofani A, Libonati A, Unida V, Biocca S, Desideri A, Campanella V (2024) Coronal and root Canal microbiota in apical periodontitis with different PAI. Microorganisms 12(8):1518","journal-title":"Microorganisms"},{"issue":"2","key":"10477_CR5","doi-asserted-by":"crossref","first-page":"111203","DOI":"10.1016\/j.injury.2023.111203","volume":"55","author":"L Cai","year":"2024","unstructured":"Cai L, Lv Y, Yan Q, Guo W (2024) Cytokines: the links between bone and the immune system. Injury 55(2):111203","journal-title":"Injury"},{"key":"10477_CR6","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez RD, Alarc\u00f3n-Riquelme ME (2024) Exploring the contribution of genetics on the clinical manifestations of systemic lupus erythematosus. Best Pract Res Clin Rheumatol.:101971","DOI":"10.1016\/j.berh.2024.101971"},{"key":"10477_CR7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/iej.13838","volume":"56","author":"MA Meire","year":"2023","unstructured":"Meire MA, Bronzato JD, Bomfim RA, Gomes BP (2023) Effectiveness of adjunct therapy for the treatment of apical periodontitis: a systematic review and meta-analysis. Int Endod J 56:455\u2013474","journal-title":"Int Endod J"},{"key":"10477_CR8","doi-asserted-by":"crossref","first-page":"1517154","DOI":"10.3389\/fcimb.2025.1517154","volume":"15","author":"Z Cui","year":"2025","unstructured":"Cui Z, Wang P, Gao W (2025) Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic. Front Cell Infect Microbiol 15:1517154","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10477_CR9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12950-024-00417-7","volume":"21","author":"H Bannazadeh Baghi","year":"2024","unstructured":"Bannazadeh Baghi H, Bayat M, Mehrasa P, Alavi SMA, Lotfalizadeh MH, Memar MY et al (2024) Regulatory role of MicroRNAs in virus-mediated inflammation. J Inflamm 21(1):43","journal-title":"J Inflamm"},{"key":"10477_CR10","doi-asserted-by":"crossref","unstructured":"Pazhouhesh Far N, Hajiheidari Varnousafaderani M, Faghihkhorasani F, Etemad S, Abdulwahid AHRR, Bakhtiarinia N et al (2025) Breaking the barriers: overcoming cancer resistance by targeting the NLRP3 inflammasome. Br J Pharmacol","DOI":"10.1111\/bph.17352"},{"key":"10477_CR11","doi-asserted-by":"crossref","first-page":"106106","DOI":"10.1016\/j.archoralbio.2024.106106","volume":"169","author":"IBF Petean","year":"2025","unstructured":"Petean IBF, Silva-Sousa AC, Mara\u00f1\u00f3n-V\u00e1squez GA, de Paula-Silva FWG, K\u00fcchler EC, Antunes LS et al (2025) Interaction between polymorphisms in TNF-\u237a and RANKL genes is associated with the development of persistent apical periodontitis, in Brazilian subjects. Arch Oral Biol 169:106106","journal-title":"Arch Oral Biol"},{"key":"10477_CR12","doi-asserted-by":"crossref","first-page":"113642","DOI":"10.1016\/j.intimp.2024.113642","volume":"144","author":"X Ye","year":"2025","unstructured":"Ye X, Chen T, Cheng J, Song Y, Ding P, Wang Z et al (2025) Causal effects of Circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis. Int Immunopharmacol 144:113642","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10477_CR13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jobcr.2024.11.009","volume":"15","author":"EP Prasetyo","year":"2025","unstructured":"Prasetyo EP, Saravanan P, Kharisna D, Wijanarko CI, Kuntjoro M, Hendrijantini N et al (2025) Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis. J Oral Biology Craniofac Res 15(1):16\u201321","journal-title":"J Oral Biology Craniofac Res"},{"key":"10477_CR14","doi-asserted-by":"crossref","first-page":"113625","DOI":"10.1016\/j.intimp.2024.113625","volume":"145","author":"PS Aghbash","year":"2025","unstructured":"Aghbash PS, Rasizadeh R, Nahand JS, Baghi HB (2025) The role of immune cells and inflammasomes in modulating cytokine responses in HPV-Related cervical cancer. Int Immunopharmacol 145:113625","journal-title":"Int Immunopharmacol"},{"key":"10477_CR15","doi-asserted-by":"crossref","unstructured":"Crow MK, Kirou KA, Niewold TB (2025) Cytokines in lupus. Dubois\u2019 lupus erythematosus and related syndromes: Elsevier; pp. 163\u2013\u200980","DOI":"10.1016\/B978-0-323-93232-5.00022-8"},{"issue":"1","key":"10477_CR16","doi-asserted-by":"crossref","first-page":"e14326","DOI":"10.1111\/eci.14326","volume":"55","author":"A Gallo","year":"2025","unstructured":"Gallo A, Le Goff W, Santos RD, Fichtner I, Carugo S, Corsini A et al (2025) Hypercholesterolemia and inflammation\u2014Cooperative cardiovascular risk factors. Eur J Clin Invest 55(1):e14326","journal-title":"Eur J Clin Invest"},{"key":"10477_CR17","unstructured":"Gonz\u00e1lez-Rodr\u00edguez MI (2025) Keeping the Balance: How the immune system is shaped by environmental microbes and the allergic signals sensed"},{"key":"10477_CR18","doi-asserted-by":"crossref","unstructured":"Dechun L, Yunxia Z (2025) Pathogenesis and pathophysiology. The pathology and imaging of coronavirus pneumonia. Elsevier, pp 27\u201338","DOI":"10.1016\/B978-0-443-32930-2.00005-2"},{"key":"10477_CR19","doi-asserted-by":"crossref","first-page":"1421353","DOI":"10.3389\/fped.2024.1421353","volume":"12","author":"A Chaaban","year":"2024","unstructured":"Chaaban A, Yassine H, Hammoud R, Kanaan R, Karam L, Ibrahim J-N (2024) A narrative review on the role of cytokines in the pathogenesis and treatment of Familial mediterranean fever: an emphasis on pediatric cases. Front Pead 12:1421353","journal-title":"Front Pead"},{"key":"10477_CR20","doi-asserted-by":"crossref","first-page":"113805","DOI":"10.1016\/j.intimp.2024.113805","volume":"146","author":"C Ohira","year":"2025","unstructured":"Ohira C, Kaneki M, Shirao D, Kurauchi N, Fukuyama T (2025) Oral treatment with Catechin isolated from Japanese green tea significantly inhibits the growth of periodontal pathogen Porphyromonas Gulae and ameliorates the gingivitis and halitosis caused by periodontal disease in cats and dogs. Int Immunopharmacol 146:113805","journal-title":"Int Immunopharmacol"},{"key":"10477_CR21","doi-asserted-by":"crossref","unstructured":"Chen J, Li H, Zhang H, ShenTu Q, Wang S, Wang F et al Dupilumab induced ocular surface diseases: an analysis of FAERS database, literature review and disease-gene interaction networks. Expert Opinion on Drug Safety. 2025(just-accepted).","DOI":"10.1080\/14740338.2024.2448825"},{"issue":"1","key":"10477_CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/life15010047","volume":"15","author":"C-I B\u0103cil\u0103","year":"2025","unstructured":"B\u0103cil\u0103 C-I, Vl\u0103doiu M-G, V\u0103leanu M, Moga D-F-C, Pumnea P-M (2025) The role of IL-6 and TNF-Alpha biomarkers in predicting disability outcomes in acute ischemic stroke patients. Life 15(1):47","journal-title":"Life"},{"key":"10477_CR23","doi-asserted-by":"crossref","first-page":"109130","DOI":"10.1016\/j.intimp.2022.109130","volume":"111","author":"M Aliyu","year":"2022","unstructured":"Aliyu M, Zohora FT, Anka AU, Ali K, Maleknia S, Saffarioun M et al (2022) Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach. Int Immunopharmacol 111:109130","journal-title":"Int Immunopharmacol"},{"key":"10477_CR24","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhu J, Zhou Y, Tang Y, Huang C (2024) Exploring relationships between Circulating interleukins and pulp and periapical diseases: A bidirectional Mendelian randomization study. J Endod","DOI":"10.1016\/j.joen.2024.11.010"},{"issue":"24","key":"10477_CR25","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.3390\/ijms252413501","volume":"25","author":"A Bojarczuk","year":"2024","unstructured":"Bojarczuk A, Garbacz A, \u017bekanowski C, Borzemska B, Ci\u0119szczyk P, Maculewicz E (2024) Systematic review of IL-1, IL-4, IL-6, IL-10, IL-15, and IL-18 gene polymorphisms and Meta-Analysis of IL-6 variant and its association with overweight and obesity risk in men. Int J Mol Sci 25(24):13501","journal-title":"Int J Mol Sci"},{"key":"10477_CR26","doi-asserted-by":"crossref","first-page":"117177","DOI":"10.1016\/j.biopha.2024.117177","volume":"178","author":"NK Bhol","year":"2024","unstructured":"Bhol NK, Bhanjadeo MM, Singh AK, Dash UC, Ojha RR, Majhi S et al (2024) The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomed Pharmacother 178:117177","journal-title":"Biomed Pharmacother"},{"key":"10477_CR27","doi-asserted-by":"crossref","unstructured":"Mallick S, Duttaroy AK, Bose B (2024) A snapshot of cytokine dynamics: A fine balance between health and disease. J Cell Biochem.:e30680","DOI":"10.1002\/jcb.30680"},{"key":"10477_CR28","doi-asserted-by":"crossref","unstructured":"Firdous SM, Pal S, Mandal S, Sindhu RK (2025) Antioxidants in Inflammatory Diseases. Antioxidants: Nature\u2019s Defense Against Disease.:83\u2013126","DOI":"10.1002\/9781394270576.ch3"},{"issue":"1","key":"10477_CR29","first-page":"101187","volume":"18","author":"J Li","year":"2025","unstructured":"Li J, Luo R, Gao W (2025) Diagnostic value of nasal sinus computed tomography\/magnetic resonance imaging examination and serum cytokines in unilateral benign sphenoid sinus lesions. J Radiation Res Appl Sci 18(1):101187","journal-title":"J Radiation Res Appl Sci"},{"issue":"1","key":"10477_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/ejdv.ejdv_50_23","volume":"45","author":"S Suneetha","year":"2025","unstructured":"Suneetha S, Das P, Singh GK, Vasudevan B, Priya KL, Mannu A et al (2025) Histological, immunohistochemical, and serological markers of lepra reactions in leprosy. Egypt J Dermatology Venerology 45(1):1\u20138","journal-title":"Egypt J Dermatology Venerology"},{"key":"10477_CR31","first-page":"1","volume-title":"Inflammatory biomarkers in periodontitis and their effect on the stem\/progenitor cells: molecular basis of bone resorption and bone regeneration","author":"D Rady","year":"2023","unstructured":"Rady D, El Moshy S, Abbass MM, Sadek KM, El-Rashidy AA, Radwan IA et al (2023) Inflammatory biomarkers in periodontitis and their effect on the stem\/progenitor cells: molecular basis of bone resorption and bone regeneration. Springer, Handbook of Stem Cell Applications, pp 1\u201337"},{"issue":"11","key":"10477_CR32","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/iej.14125","volume":"57","author":"YH Wen","year":"2024","unstructured":"Wen YH, Lin YX, Zhou L, Lin C, Zhang L (2024) The immune landscape in apical periodontitis: from mechanism to therapy. Int Endod J 57(11):1526\u20131545","journal-title":"Int Endod J"},{"key":"10477_CR33","doi-asserted-by":"crossref","unstructured":"Wang J-M, Jiang H-W, Zhang Y-Q, Hu Y, Mei H Hemophagocytic lymphohistiocytosis post chimeric antigen receptor T cell therapies. Expert Rev Clin Immunol. 2025(just-accepted).","DOI":"10.1080\/1744666X.2024.2444673"},{"key":"10477_CR34","doi-asserted-by":"crossref","unstructured":"Chen D, Chen B, Li G, Wang H (2021) IL-18 haplotype GCAGT and IL-18R1 rs3755276 genotype CC combinatively associated with severity of ventilator associated pneumonia (VAP) in intensive care unit (ICU) patients","DOI":"10.21203\/rs.3.rs-523663\/v1"},{"issue":"3","key":"10477_CR35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/reports7030074","volume":"7","author":"C Cucoreanu","year":"2024","unstructured":"Cucoreanu C, Muresan XM, Tigu A-B, Nistor M, Moldovan R-C, Pralea I-E et al (2024) The relationship between Proinflammatory molecules and PD-L1 in patients with obesity who underwent gastric sleeve Surgery\u2014A pilot study. Reports 7(3):74","journal-title":"Reports"},{"key":"10477_CR36","doi-asserted-by":"crossref","first-page":"113803","DOI":"10.1016\/j.intimp.2024.113803","volume":"145","author":"Y Wang","year":"2025","unstructured":"Wang Y, Ge J, Dou M, Cheng X, Chen X, Ma L et al (2025) Inhibition of CCR2 attenuates NLRP3-dependent pyroptosis after myocardial ischaemia\u2013reperfusion in rats via the NF-kB pathway. Int Immunopharmacol 145:113803","journal-title":"Int Immunopharmacol"},{"key":"10477_CR37","doi-asserted-by":"crossref","unstructured":"Narang JK, Dogra A, Kaur T, Narang RS, Singh AP (2025) Antioxidants Against Neurological Disorders. Antioxidants: Nature\u2019s Defense Against Disease.:285\u2013367","DOI":"10.1002\/9781394270576.ch9"},{"key":"10477_CR38","doi-asserted-by":"crossref","first-page":"108348","DOI":"10.1016\/j.pharmthera.2023.108348","volume":"242","author":"Y G\u00e4rtner","year":"2023","unstructured":"G\u00e4rtner Y, Bitar L, Zipp F, Vogelaar CF (2023) Interleukin-4 as a therapeutic target. Pharmacol Ther 242:108348","journal-title":"Pharmacol Ther"},{"issue":"2","key":"10477_CR39","doi-asserted-by":"crossref","first-page":"194760352210981","DOI":"10.1177\/19476035221098167","volume":"13","author":"E Van Helvoort","year":"2022","unstructured":"Van Helvoort E, Van Der HEIJDENE, Van Roon J, Eijkelkamp N, Mastbergen S (2022) The role of interleukin-4 and interleukin-10 in Osteoarthritic joint disease: A systematic narrative review. Cartilage 13(2):19476035221098167","journal-title":"Cartilage"},{"key":"10477_CR40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jconrel.2024.12.042","volume":"378","author":"W Guo","year":"2025","unstructured":"Guo W, Chen H, Liu F, Chen B, Liu C, Cai Y (2025) Peptide amphiphiles alleviate myocardial Endoplasmic reticulum stress to enhance cardiomyocyte\u2013macrophage communication and promote macrophage M2 polarization. J Controlled Release 378:719\u2013734","journal-title":"J Controlled Release"},{"issue":"4","key":"10477_CR41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.joen.2024.01.018","volume":"50","author":"RC Rodrigues","year":"2024","unstructured":"Rodrigues RC, Porpino MT, Dessaune-Neto N, Antunes HS, Pinto KM, Provenzano JC et al (2024) Correlation between Proinflammatory cytokine expression and clinical data in apical granuloma. J Endod 50(4):499\u2013505","journal-title":"J Endod"},{"issue":"1","key":"10477_CR42","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s10020-024-00989-3","volume":"30","author":"Y Chen","year":"2024","unstructured":"Chen Y, Ullah A, Chen W, Xuan J, Huang X, Liang S et al (2024) Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets. Mol Med 30(1):214","journal-title":"Mol Med"},{"issue":"1","key":"10477_CR43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41368-024-00278-z","volume":"16","author":"J Lin","year":"2024","unstructured":"Lin J, Wang C, Wang X, Chen F, Zhang W, Sun H et al (2024) Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment. Int J Oral Sci 16(1):11","journal-title":"Int J Oral Sci"},{"issue":"11","key":"10477_CR44","first-page":"e74389","volume":"16","author":"AM Falatah","year":"2024","unstructured":"Falatah AM, Alturki SA, Aldahami AI, Alrashidi NA, Sinnah Y, Aldgeel RM et al (2024) Exploring the influence of genetic Single-Nucleotide polymorphism (SNPs) on endodontic pathologies: A comprehensive review. Cureus 16(11):e74389","journal-title":"Cureus"},{"issue":"1","key":"10477_CR45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12863-024-01233-x","volume":"25","author":"O Abuzaid","year":"2024","unstructured":"Abuzaid O, Idris AB, Y\u0131lmaz S, Idris EB, Idris LB, Hassan MA (2024) Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses. BMC Genomic Data 25(1):56","journal-title":"BMC Genomic Data"},{"key":"10477_CR46","doi-asserted-by":"crossref","unstructured":"Ullah A, Chen Y, Singla RK, Cao D, Shen B (2024) Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal Women-Diabetes, metabolic bone diseases, and non-alcohol fatty liver disease. Ageing Res Rev.:102505","DOI":"10.1016\/j.arr.2024.102505"},{"issue":"1","key":"10477_CR47","doi-asserted-by":"crossref","first-page":"23716","DOI":"10.1038\/s41598-024-73205-1","volume":"14","author":"X-a Yan","year":"2024","unstructured":"Yan X-a, Shen E, Cui A, Zhou F, Zhuang Y (2024) Assessing the causal relationship between CRP, IL-1 \u0391, IL-1 \u0392, and IL-6 levels and intervertebral disc degeneration: a two-sample Mendelian randomization study. Sci Rep 14(1):23716","journal-title":"Sci Rep"},{"issue":"3","key":"10477_CR48","doi-asserted-by":"crossref","first-page":"e1234","DOI":"10.52225\/narra.v4i3.1234","volume":"4","author":"D Darnifayanti","year":"2024","unstructured":"Darnifayanti D, Akmal M, Nur S, Yusuf S (2024) Association between tumor necrosis factor-\u03b1 gene polymorphism and interleukin-6 level with mortality of neonatal sepsis. Narra J 4(3):e1234\u2013e","journal-title":"Narra J"},{"issue":"7","key":"10477_CR49","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s42255-023-00846-3","volume":"5","author":"A Douglas","year":"2023","unstructured":"Douglas A, Stevens B, Lynch L (2023) Interleukin-17 as a key player in neuroimmunometabolism. Nat Metabolism 5(7):1088\u20131100","journal-title":"Nat Metabolism"},{"key":"10477_CR50","doi-asserted-by":"crossref","unstructured":"Natura G, Vazquez E, Richter F, von Banchet GS, Ebbinghaus M, Ebersberger A et al (2025) Antinociceptive interactions between excitatory interferon-\u03b3 and interleukin-17 in sensory neurons. Brain, Behavior, and Immunity.;124:55\u201373","DOI":"10.1016\/j.bbi.2024.11.021"},{"key":"10477_CR51","doi-asserted-by":"crossref","unstructured":"Lewis DB, Weitkamp J-H, Levy O (2025) Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection. Remington and Klein\u2019s Infectious Diseases of the Fetus and Newborn Infant. Elsevier, pp 73\u2013159. e14","DOI":"10.1016\/B978-0-323-79525-8.00013-5"},{"issue":"11","key":"10477_CR52","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/joor.13834","volume":"51","author":"P Niibo","year":"2024","unstructured":"Niibo P, Nikopensius T, Jagom\u00e4gi T, Voog \u00dc, Haller T, T\u00f5nisson N et al (2024) Genetic susceptibility to temporomandibular joint involvement in juvenile idiopathic arthritis. J Rehabil 51(11):2445\u20132451","journal-title":"J Rehabil"},{"key":"10477_CR53","doi-asserted-by":"crossref","unstructured":"Ciurtin C, Helmy GA, Ferreira AC, Manson JJ, Jury EC, McDonnell T (2024) A Tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis. Clin Immunol.:110281","DOI":"10.1016\/j.clim.2024.110281"},{"issue":"1","key":"10477_CR54","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12985-024-02597-3","volume":"21","author":"JQ Yip","year":"2024","unstructured":"Yip JQ, Oo A, Ng YL, Chin KL, Tan K-K, Chu JJH et al (2024) The role of inflammatory gene polymorphisms in severe COVID-19: a review. Virol J 21(1):327","journal-title":"Virol J"},{"key":"10477_CR55","first-page":"1","volume-title":"The role of Interleukin gene variations in intellectual disability","author":"N Alkanli","year":"2024","unstructured":"Alkanli N, Alkanli SS, Ay A (2024) The role of Interleukin gene variations in intellectual disability. Springer, The Palgrave Encyclopedia of Disability, pp 1\u20138"},{"issue":"14","key":"10477_CR56","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.3390\/ijms25147666","volume":"25","author":"F Yasmeen","year":"2024","unstructured":"Yasmeen F, Pirzada RH, Ahmad B, Choi B, Choi S (2024) Understanding autoimmunity: mechanisms, predisposing factors, and cytokine therapies. Int J Mol Sci 25(14):7666","journal-title":"Int J Mol Sci"},{"key":"10477_CR57","doi-asserted-by":"crossref","first-page":"1393799","DOI":"10.3389\/fimmu.2024.1393799","volume":"15","author":"M Morelli","year":"2024","unstructured":"Morelli M, Madonna S, Albanesi C (2024) SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation. Front Immunol 15:1393799","journal-title":"Front Immunol"},{"issue":"1","key":"10477_CR58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12879-024-09149-8","volume":"24","author":"F Thiam","year":"2024","unstructured":"Thiam F, Diop G, Coulonges C, Derbois C, Thiam A, Diouara AAM et al (2024) An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant. BMC Infect Dis 24(1):275","journal-title":"BMC Infect Dis"},{"key":"10477_CR59","doi-asserted-by":"crossref","unstructured":"Danieli MG, Casciaro M, Paladini A, Bartolucci M, Sordoni M, Shoenfeld Y et al (2024) Exposome: epigenetics and autoimmune diseases. Autoimmun Rev.:103584","DOI":"10.1016\/j.autrev.2024.103584"},{"issue":"1","key":"10477_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-024-01093-8","volume":"32","author":"J Wang","year":"2025","unstructured":"Wang J, Li C, Han J, Xue Y, Zheng X, Wang R et al (2025) Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis. J Biomed Sci 32(1):1","journal-title":"J Biomed Sci"},{"issue":"1","key":"10477_CR61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1152\/physiol.00021.2024","volume":"40","author":"M Cifuentes","year":"2025","unstructured":"Cifuentes M, Verdejo HE, Castro PF, Corvalan AH, Ferreccio C, Quest AF et al (2025) Low-grade chronic inflammation: A shared mechanism for chronic diseases. Physiology 40(1):4\u201325","journal-title":"Physiology"},{"issue":"6","key":"10477_CR62","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3390\/metabo11060406","volume":"11","author":"C Caffaratti","year":"2021","unstructured":"Caffaratti C, Plazy C, Mery G, Tidjani A-R, Fiorini F, Thiroux S et al (2021) What we know so Far about the metabolite-mediated microbiota-intestinal immunity dialogue and how to hear the sound of this crosstalk. Metabolites 11(6):406","journal-title":"Metabolites"},{"issue":"9","key":"10477_CR63","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.3390\/ijms22094483","volume":"22","author":"P Wigner","year":"2021","unstructured":"Wigner P, Gr\u0119bowski R, Bijak M, Saluk-Bijak J, Szemraj J (2021) The interplay between oxidative stress, inflammation and angiogenesis in bladder cancer development. Int J Mol Sci 22(9):4483","journal-title":"Int J Mol Sci"},{"key":"10477_CR64","unstructured":"Cardinez CT (2022) IKBKB Gain-of-Function in human disease. The Australian National University (Australia)"},{"issue":"6","key":"10477_CR65","first-page":"2","volume":"16","author":"X Fan","year":"2025","unstructured":"Fan X, Xu H, Prasadam I, Sun AR, Wu X, Crawford R et al (2025) Spatiotemperal dynamics of osteoarthritis: bridging insights from bench to bedside. Aging Disease 16(6):2","journal-title":"Aging Disease"},{"issue":"4","key":"10477_CR66","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1002\/mco2.173","volume":"3","author":"S Zhang","year":"2022","unstructured":"Zhang S, Meng Y, Zhou L, Qiu L, Wang H, Su D et al (2022) Targeting epigenetic regulators for inflammation: mechanisms and intervention therapy. MedComm 3(4):e173","journal-title":"MedComm"},{"key":"10477_CR67","doi-asserted-by":"crossref","first-page":"756458","DOI":"10.3389\/fcell.2021.756458","volume":"9","author":"D Das","year":"2021","unstructured":"Das D, Karthik N, Taneja R (2021) Crosstalk between inflammatory signaling and methylation in cancer. Front Cell Dev Biology 9:756458","journal-title":"Front Cell Dev Biology"},{"key":"10477_CR68","doi-asserted-by":"crossref","unstructured":"Kaur S, Mishra J, Sehrawat A, Bhatti GK, Navik U, Reddy PH et al (2023) Epigenetic regulators of inflammatory gene expression. Targeting epigenetics in inflammatory lung diseases. Springer, pp 57\u201388","DOI":"10.1007\/978-981-99-4780-5_4"},{"key":"10477_CR69","doi-asserted-by":"crossref","unstructured":"Valverde A, George A, Nares S, Naqvi AR (2024) Emerging therapeutic strategies targeting bone signaling pathways in periodontitis. J Periodontal Res","DOI":"10.1111\/jre.13326"},{"key":"10477_CR70","unstructured":"Hussain SB (2024) Association between periodontitis and rheumatic diseases. UCL (University College London)"},{"issue":"3","key":"10477_CR71","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3390\/ijms23031731","volume":"23","author":"JP Lu\u00eds","year":"2022","unstructured":"Lu\u00eds JP, Sim\u00f5es CJ, Brito RM (2022) The therapeutic prospects of targeting IL-1R1 for the modulation of neuroinflammation in central nervous system disorders. Int J Mol Sci 23(3):1731","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10477_CR72","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s40005-023-00631-0","volume":"53","author":"T-D Nguyen","year":"2023","unstructured":"Nguyen T-D, Dang LN, Jang J-H, Park S (2023) Recent advances in Alzheimer\u2019s disease pathogenesis and therapeutics from an immune perspective. J Pharm Invest 53(5):667\u2013684","journal-title":"J Pharm Invest"},{"key":"10477_CR73","doi-asserted-by":"crossref","first-page":"155655","DOI":"10.1016\/j.cyto.2021.155655","volume":"146","author":"NA Sims","year":"2021","unstructured":"Sims NA (2021) Influences of the IL-6 cytokine family on bone structure and function. Cytokine 146:155655","journal-title":"Cytokine"},{"issue":"6","key":"10477_CR74","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11914-023-00824-4","volume":"21","author":"HM Torres","year":"2023","unstructured":"Torres HM, Arnold KM, Oviedo M, Westendorf JJ, Weaver SR (2023) Inflammatory processes affecting bone health and repair. Curr Osteoporos Rep 21(6):842\u2013853","journal-title":"Curr Osteoporos Rep"},{"key":"10477_CR75","doi-asserted-by":"crossref","first-page":"155742","DOI":"10.1016\/j.cyto.2021.155742","volume":"149","author":"M Jarlborg","year":"2022","unstructured":"Jarlborg M, Gabay C (2022) Systemic effects of IL-6 Blockade in rheumatoid arthritis beyond the joints. Cytokine 149:155742","journal-title":"Cytokine"},{"issue":"3","key":"10477_CR76","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/ijms22031480","volume":"22","author":"KM Galler","year":"2021","unstructured":"Galler KM, Weber M, Korkmaz Y, Widbiller M, Feuerer M (2021) Inflammatory response mechanisms of the dentine\u2013pulp complex and the periapical tissues. Int J Mol Sci 22(3):1480","journal-title":"Int J Mol Sci"},{"key":"10477_CR77","doi-asserted-by":"crossref","unstructured":"Prabhu P S (2025) Pathology of inflammation and inflammatory diseases of the Oro-Facial complex: an overview. Pathological Basis Oral Maxillofacial Dis 175:95","DOI":"10.1002\/9781119989233.ch12"},{"key":"10477_CR78","doi-asserted-by":"crossref","unstructured":"Davidson A (2025) Lupus nephritis. Dubois\u2019 Lupus Erythematosus and Related Syndromes: Elsevier; pp. 292\u2013315","DOI":"10.1016\/B978-0-323-93232-5.00029-0"},{"key":"10477_CR79","doi-asserted-by":"crossref","unstructured":"Ratner AJ, Nizet V, Puopolo KM (2025) Group B streptococcal infections. Remington and Klein\u2019s Infectious Diseases of the Fetus and Newborn Infant. Elsevier, pp 348\u2013378. e11","DOI":"10.1016\/B978-0-323-79525-8.00022-6"},{"key":"10477_CR80","doi-asserted-by":"crossref","first-page":"113894","DOI":"10.1016\/j.intimp.2024.113894","volume":"146","author":"H Liu","year":"2025","unstructured":"Liu H, Sun C, Jiang Y, Gao R, Ying Q, Li X et al (2025) Eldecalcitol alleviates diabetic periodontitis by regulating macrophage efferocytosis and polarization via SOCE machinery. Int Immunopharmacol 146:113894","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10477_CR81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10735-024-10322-1","volume":"56","author":"Y Yang","year":"2025","unstructured":"Yang Y, Ren D, Peng B, Huang J, Yang B (2025) The role of FOXM1 in acetylcysteine improving diabetic periodontitis. J Mol Histol 56(1):1\u201310","journal-title":"J Mol Histol"},{"key":"10477_CR82","doi-asserted-by":"crossref","first-page":"102624","DOI":"10.1016\/j.nantod.2024.102624","volume":"61","author":"Y Li","year":"2025","unstructured":"Li Y, Muhammad F, Chen X, Gu D, Li W, Tang J et al (2025) Smart multifunctional Cu2O@ RuO2 nanozyme for angiogenesis and osteogenesis in periodontitis. Nano Today 61:102624","journal-title":"Nano Today"},{"issue":"1","key":"10477_CR83","first-page":"1","volume":"29","author":"C \u00d6zden","year":"2025","unstructured":"\u00d6zden C, Afacan B, \u0130lhan HA, K\u00f6se T, Emingil G (2025) Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis. Clin Oral Invest 29(1):1\u201311","journal-title":"Clin Oral Invest"},{"issue":"1","key":"10477_CR84","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/diagnostics15010078","volume":"15","author":"G S\u00e1enz-Ravello","year":"2025","unstructured":"S\u00e1enz-Ravello G, Hern\u00e1ndez M, Baeza M, Hern\u00e1ndez-R\u00edos P (2025) The role of oral biomarkers in the assessment of noncommunicable diseases. Diagnostics 15(1):78","journal-title":"Diagnostics"},{"issue":"10","key":"10477_CR85","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/ph17101294","volume":"17","author":"K Adhikary","year":"2024","unstructured":"Adhikary K, Sarkar R, Maity S, Sadhukhan I, Sarkar R, Ganguly K et al (2024) Immunomodulation of macrophages in diabetic wound individuals by structurally diverse bioactive phytochemicals. Pharmaceuticals 17(10):1294","journal-title":"Pharmaceuticals"},{"issue":"3","key":"10477_CR86","doi-asserted-by":"crossref","first-page":"H655","DOI":"10.1152\/ajpheart.00559.2023","volume":"326","author":"C Dufeys","year":"2024","unstructured":"Dufeys C, Bodart J, Bertrand L, Beauloye C, Horman S (2024) Fibroblasts and platelets: a face-to-face dialogue at the heart of cardiac fibrosis. Am J Physiol Heart Circ Physiol 326(3):H655\u2013H69","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10477_CR87","doi-asserted-by":"crossref","first-page":"C1011","DOI":"10.1152\/ajpcell.00638.2023","volume":"326","author":"CA Bellissimo","year":"2024","unstructured":"Bellissimo CA, Gandhi S, Castellani LN, Murugathasan M, Delfinis LJ, Thuhan A et al (2024) The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2. Mdx mouse model of Duchenne muscular dystrophy. Am J Physiology-Cell Physiol 326(4):C1011\u2013C26","journal-title":"Am J Physiology-Cell Physiol"},{"key":"10477_CR88","doi-asserted-by":"crossref","unstructured":"Shen J, Chen Y, Zhang Y, Zhang C, Liu H (2025) Multifaceted roles of IL-17 in bone and tendon health. Int J Biol Macromol.:139498","DOI":"10.1016\/j.ijbiomac.2025.139498"},{"issue":"1","key":"10477_CR89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41522-024-00623-4","volume":"11","author":"M Xia","year":"2025","unstructured":"Xia M, Lei L, Zhao L, Xu W, Zhang H, Li M et al (2025) The dynamic oral\u2013gastric microbial axis connects oral and gastric health: current evidence and disputes. Npj Biofilms Microbiomes 11(1):1","journal-title":"Npj Biofilms Microbiomes"},{"key":"10477_CR90","doi-asserted-by":"crossref","unstructured":"Mukherjee S, Chopra A, Karmakar S, Bhat SG (2024) Periodontitis increases the risk of Gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms. Crit Rev Microbiol.:1\u201331","DOI":"10.1080\/1040841X.2024.2339260"},{"key":"10477_CR91","doi-asserted-by":"crossref","first-page":"1430193","DOI":"10.3389\/fdmed.2024.1430193","volume":"5","author":"CC Villar","year":"2024","unstructured":"Villar CC, Sloniak MC, Assis JBd, Porto RC, Romito GA (2024) Unveiling sex-disparities and the impact of gender-affirming hormone therapy on periodontal health. Front Dent Med 5:1430193","journal-title":"Front Dent Med"},{"issue":"3","key":"10477_CR92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/diagnostics13030471","volume":"13","author":"V Spasovski","year":"2023","unstructured":"Spasovski V, Srzenti\u0107 Dra\u017eilov S, Nik\u010devi\u0107 G, Ba\u0161\u010darevi\u0107 Z, Stojiljkovi\u0107 M, Pavlovi\u0107 S et al (2023) Molecular biomarkers in Perthes disease: A review. Diagnostics 13(3):471","journal-title":"Diagnostics"},{"issue":"12","key":"10477_CR93","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.3390\/ph17121697","volume":"17","author":"K Stromsnes","year":"2024","unstructured":"Stromsnes K, Fajardo CM, Soto-Rodriguez S, Kajander ERU, Lupu R-I, Pozo-Rodriguez M et al (2024) Osteoporosis: causes, mechanisms, treatment and prevention: role of dietary compounds. Pharmaceuticals 17(12):1697","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10477_CR94","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3390\/ijms25042369","volume":"25","author":"IE Stergiou","year":"2024","unstructured":"Stergiou IE, Tsironis C, Papadakos SP, Tsitsilonis OE, Dimopoulos MA, Theocharis S (2024) Unraveling the role of the NLRP3 inflammasome in lymphoma: implications in pathogenesis and therapeutic strategies. Int J Mol Sci 25(4):2369","journal-title":"Int J Mol Sci"},{"key":"10477_CR95","doi-asserted-by":"crossref","first-page":"1482947","DOI":"10.3389\/fnagi.2024.1482947","volume":"16","author":"J Wu","year":"2024","unstructured":"Wu J, Tang J, Huang D, Wang Y, Zhou E, Ru Q et al (2024) Effects and mechanisms of APP and its cleavage product A\u03b2 in the comorbidity of sarcopenia and Alzheimer\u2019s disease. Front Aging Neurosci 16:1482947","journal-title":"Front Aging Neurosci"},{"key":"10477_CR96","doi-asserted-by":"crossref","unstructured":"Prosnitz AR, Gruen JR, Bhandari V (2022) The genetics of disorders affecting the premature newborn. Emery and Rimoin\u2019s Principles and Practice of Medical Genetics and Genomics. Elsevier, pp 149\u2013185","DOI":"10.1016\/B978-0-12-815236-2.00006-0"},{"key":"10477_CR97","volume-title":"The etiology of Peri-Implantitis: Microbiological profile within and around dental implants and the associated","author":"AA Kensara","year":"2023","unstructured":"Kensara AA (2023) The etiology of Peri-Implantitis: Microbiological profile within and around dental implants and the associated. University of Maryland, Baltimore, Human Immune Response"},{"key":"10477_CR98","doi-asserted-by":"crossref","unstructured":"Cheng W, Li F, Tian J, Xie X, Chen J-W, Peng X-F et al (2022) New insights in the treatment of SAPHO syndrome and medication recommendations. J Inflamm Res.:2365\u20132380","DOI":"10.2147\/JIR.S353539"},{"issue":"11","key":"10477_CR99","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00296-023-05491-3","volume":"44","author":"T Demirci Yildirim","year":"2024","unstructured":"Demirci Yildirim T, Sari \u0130 (2024) SAPHO syndrome: current clinical, diagnostic and treatment approaches. Rheumatol Int 44(11):2301\u20132313","journal-title":"Rheumatol Int"},{"key":"10477_CR100","doi-asserted-by":"crossref","unstructured":"Chatterjee A, Jayaprakasan M, Chakrabarty AK, Lakkaniga NR, Bhatt BN, Banerjee D et al (2024) Comprehensive insights into rheumatoid arthritis: pathophysiology, current therapies and herbal alternatives for effective disease management. Phytother Res","DOI":"10.1002\/ptr.8187"},{"key":"10477_CR101","doi-asserted-by":"crossref","unstructured":"Julve M, Wong YNS, Lim KHJ, Furness AJ (2024) Solid tumour cellular therapy\u2013principles of toxicity management. Immuno-Oncology Technol.:100737","DOI":"10.1016\/j.iotech.2024.100737"},{"key":"10477_CR102","doi-asserted-by":"crossref","unstructured":"Rajdan N, Srivastava B, Sharma K Rheumatoid arthritis: treatments available at present. Nanotherapeutics for Inflammatory Arthritis: CRC. pp. 243\u2013295","DOI":"10.1201\/9781003348672-13"},{"key":"10477_CR103","doi-asserted-by":"crossref","first-page":"1435306","DOI":"10.3389\/fimmu.2024.1435306","volume":"15","author":"X Gong","year":"2024","unstructured":"Gong X, Yang S-Y, Wang Z-Y, Tang M (2024) The role of hypoxic microenvironment in autoimmune diseases. Front Immunol 15:1435306","journal-title":"Front Immunol"},{"issue":"1","key":"10477_CR104","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s43168-024-00335-5","volume":"18","author":"AA Zidan","year":"2024","unstructured":"Zidan AA, Gad AY, Zakaria NH, El-Hariri HM, Elsharnouby NM, Helmy MW et al (2024) The use of interleukin-10 (IL-10) and phosphorus levels as predictors of the time to improvement in COVID-19 patients: a prospective study. Egypt J Bronchol 18(1):84","journal-title":"Egypt J Bronchol"},{"issue":"1","key":"10477_CR105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.47665\/tb.41.1.009","volume":"41","author":"A Jaleel","year":"2024","unstructured":"Jaleel A, Namoos K, Asim S, Uppal S, Zaman S, Irfan H et al (2024) RESEARCH ARTICLE interplay of interleukins (IL6, IL10) and 25 hydroxycholecalciferol in asthmatic subjects with chronic post-COVID condition (PCC). Trop Biomed 41(1):70\u201377","journal-title":"Trop Biomed"},{"issue":"9","key":"10477_CR106","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.5498\/wjp.v14.i9.1308","volume":"14","author":"W-Y Wang","year":"2024","unstructured":"Wang W-Y, Liu N, Qi X-X, Han B, Sun J-N, Chen Z-L et al (2024) Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder. World J Psychiatry 14(9):1308","journal-title":"World J Psychiatry"},{"key":"10477_CR107","doi-asserted-by":"crossref","first-page":"039463202412768","DOI":"10.1177\/03946320241276899","volume":"38","author":"P Bayati","year":"2024","unstructured":"Bayati P, Taherian M, Mojtabavi N (2024) Immunomodulatory effects of the induced pluripotent stem cells through expressing IGF-related factors and IL-10 in vitro. Int J ImmunoPathol Pharmacol 38:03946320241276899","journal-title":"Int J ImmunoPathol Pharmacol"},{"key":"10477_CR108","doi-asserted-by":"crossref","first-page":"702507","DOI":"10.3389\/fcvm.2021.702507","volume":"8","author":"R Moll-Bernardes","year":"2021","unstructured":"Moll-Bernardes R, De Sousa AS, Macedo AV, Lopes RD, Vera N, Maia LC et al (2021) IL-10 and IL-12 (P70) levels predict the risk of Covid-19 progression in hypertensive patients: insights from the BRACE-CORONA trial. Front Cardiovasc Med 8:702507","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10477_CR109","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/jpm12061003","volume":"12","author":"M Krasselt","year":"2022","unstructured":"Krasselt M, Gruz N, Pierer M, Baerwald C, Wagner U (2022) IL-10 induced by mTNF Crosslinking-Mediated reverse signaling in a whole blood assay is predictive of response to TNFi therapy in rheumatoid arthritis. J Personalized Med 12(6):1003","journal-title":"J Personalized Med"},{"key":"10477_CR110","doi-asserted-by":"crossref","unstructured":"Wylie E, Clarke S (2023) Key Conditions and Principles of Orthopaedic Management. Orthopaedic and Trauma Nursing: An Evidence-based Approach to Musculoskeletal Care.:157\u2013\u200979","DOI":"10.1002\/9781119833413.ch13"},{"key":"10477_CR111","unstructured":"Fares S, Omar M, Laurence A, Abu-Baker S, Shaza A, Fadi H et al (2025) Over-the-Counter Anti-inflammatory supplements for adjunctive rheumatoid arthritis therapy: A comprehensive narrative review. Aging Disease"},{"key":"10477_CR112","first-page":"41","volume-title":"Application of nanotechnology in diagnostics of rheumatoid arthritis","author":"D Tripathi","year":"2025","unstructured":"Tripathi D, Rathour K, Kumari J, Mishra V, Shukla V (2025) Application of nanotechnology in diagnostics of rheumatoid arthritis. CRC, Nanotherapeutics for Inflammatory Arthritis, pp 41\u201363"},{"issue":"1","key":"10477_CR113","doi-asserted-by":"crossref","first-page":"a041231","DOI":"10.1101\/cshperspect.a041231","volume":"15","author":"R Schuster","year":"2023","unstructured":"Schuster R, Younesi F, Ezzo M, Hinz B (2023) The role of myofibroblasts in physiological and pathological tissue repair. Cold Spring Harb Perspect Biol 15(1):a041231","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"26","key":"10477_CR114","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.2174\/1381612829666230904150808","volume":"29","author":"S Akhter","year":"2023","unstructured":"Akhter S, Tasnin FM, Islam MN, Rauf A, Mitra S, Emran TB et al (2023) Role of Th17 and IL-17 cytokines on inflammatory and Auto-immune diseases. Curr Pharm Design 29(26):2078\u20132090","journal-title":"Curr Pharm Design"},{"key":"10477_CR115","doi-asserted-by":"crossref","first-page":"905727","DOI":"10.3389\/fimmu.2022.905727","volume":"13","author":"C-Y Lo","year":"2022","unstructured":"Lo C-Y, Wang C-H, Wang C-W, Chen C-J, Huang H-Y, Chung F-T et al (2022) Increased interleukin-17 and glucocorticoid receptor-\u03b2 expression in interstitial lung diseases and corticosteroid insensitivity. Front Immunol 13:905727","journal-title":"Front Immunol"},{"key":"10477_CR116","doi-asserted-by":"crossref","first-page":"108402","DOI":"10.1016\/j.intimp.2021.108402","volume":"102","author":"SD-G Berry","year":"2022","unstructured":"Berry SD-G, Dossou C, Kashif A, Sharifinejad N, Azizi G, Hamedifar H et al (2022) The role of IL-17 and anti-IL-17 agents in the Immunopathogenesis and management of autoimmune and inflammatory diseases. Int Immunopharmacol 102:108402","journal-title":"Int Immunopharmacol"},{"key":"10477_CR117","doi-asserted-by":"crossref","unstructured":"Cabrera Abad DP, Jara Vergara VC, Alvarez Vasquez JL (2024) Exploring the Painless Nature and Potential Mechanisms of Asymptomatic Irreversible Pulpitis: A Narrative Review","DOI":"10.2174\/0118742106281444240219050149"},{"key":"10477_CR118","unstructured":"Cabrera Abad DP, Jara Vergara VC (2022) Understanding asymptomatic irreversible pulpitis: an update"},{"key":"10477_CR119","unstructured":"Anvery S (2022) The association between obstructive sleep apnea and orthodontically induced inflammatory root resorption: A retrospective study. State University of New York at Buffalo"},{"key":"10477_CR120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molimm.2023.11.005","volume":"164","author":"MS Iqbal","year":"2023","unstructured":"Iqbal MS, Peng K, Sardar N, Iqbal MH, Ghani MU, Tanvir F et al (2023) Interleukins-6\u2013\u2009174G\/C (rs1800795) and\u2013\u2009572\u00a0C\/G (rs1800796) polymorphisms and prostate cancer risk. Mol Immunol 164:88\u201397","journal-title":"Mol Immunol"},{"issue":"1","key":"10477_CR121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11033-024-10101-x","volume":"52","author":"V Niazi","year":"2025","unstructured":"Niazi V, Parseh B (2025) Organoid models of breast cancer in precision medicine and translational research. Mol Biol Rep 52(1):1\u201313","journal-title":"Mol Biol Rep"},{"issue":"4","key":"10477_CR122","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.3390\/ijms25042320","volume":"25","author":"Z Firdaus","year":"2024","unstructured":"Firdaus Z, Li X (2024) Unraveling the genetic landscape of neurological disorders: insights into pathogenesis, techniques for variant identification, and therapeutic approaches. Int J Mol Sci 25(4):2320","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10477_CR123","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/diagnostics13030337","volume":"13","author":"M Singh","year":"2023","unstructured":"Singh M, Agarwal V, Jindal D, Pancham P, Agarwal S, Mani S et al (2023) Recent updates on corticosteroid-induced neuropsychiatric disorders and theranostic advancements through gene editing tools. Diagnostics 13(3):337","journal-title":"Diagnostics"},{"key":"10477_CR124","doi-asserted-by":"crossref","first-page":"113918","DOI":"10.1016\/j.addr.2021.113918","volume":"178","author":"R Raguraman","year":"2021","unstructured":"Raguraman R, Srivastava A, Munshi A, Ramesh R (2021) Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer. Adv Drug Deliv Rev 178:113918","journal-title":"Adv Drug Deliv Rev"},{"key":"10477_CR125","doi-asserted-by":"crossref","first-page":"155721","DOI":"10.1016\/j.cyto.2021.155721","volume":"149","author":"M Liu","year":"2022","unstructured":"Liu M, Yuan W, Park S (2022) Association between IL-10 rs3024505 and susceptibility to inflammatory bowel disease: A systematic review and meta-analysis. Cytokine 149:155721","journal-title":"Cytokine"},{"issue":"8","key":"10477_CR126","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41591-022-01891-3","volume":"28","author":"C Tcheandjieu","year":"2022","unstructured":"Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S et al (2022) Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med 28(8):1679\u20131692","journal-title":"Nat Med"},{"key":"10477_CR127","unstructured":"20 BCCJRWMWLRSMSDPPM (2007) A. 2 TDCDGDDBNSSHEWNMWBTJ. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature.;447(7145):661\u2013\u200978"},{"issue":"4","key":"10477_CR128","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s13167-022-00304-2","volume":"13","author":"N Jain","year":"2022","unstructured":"Jain N, Nagaich U, Pandey M, Chellappan DK, Dua K (2022) Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements. EPMA J 13(4):561\u2013580","journal-title":"EPMA J"},{"issue":"4","key":"10477_CR129","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/metabo14040198","volume":"14","author":"MS Tudor","year":"2024","unstructured":"Tudor MS, Gheorman V, Simeanu G-M, Dobrinescu A, P\u0103dureanu V, Dinescu VC et al (2024) Evolutive models, algorithms and predictive parameters for the progression of hepatic steatosis. Metabolites 14(4):198","journal-title":"Metabolites"},{"key":"10477_CR130","doi-asserted-by":"crossref","unstructured":"Lorenzano S (2021) Future application: prognosis determination. Precision medicine in stroke. Springer, pp 191\u2013258","DOI":"10.1007\/978-3-030-70761-3_9"},{"key":"10477_CR131","doi-asserted-by":"crossref","first-page":"1103349","DOI":"10.3389\/fneur.2023.1103349","volume":"14","author":"W Cao","year":"2023","unstructured":"Cao W, Zhang X, Qiu H (2023) Rehabilomics: A state-of-the-art review of framework, application, and future considerations. Front Neurol 14:1103349","journal-title":"Front Neurol"},{"issue":"3","key":"10477_CR132","doi-asserted-by":"crossref","first-page":"100986","DOI":"10.1016\/j.gendis.2023.04.021","volume":"11","author":"SN Juma","year":"2024","unstructured":"Juma SN, Liao J, Huang Y, Vlashi R, Wang Q, Wu B et al (2024) Osteoarthritis versus psoriasis arthritis: physiopathology, cellular signaling, and therapeutic strategies. Genes Dis 11(3):100986","journal-title":"Genes Dis"},{"issue":"8","key":"10477_CR133","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/14728222.2023.2247559","volume":"27","author":"TH Zaninelli","year":"2023","unstructured":"Zaninelli TH, Martelossi-Cebinelli G, Saraiva-Santos T, Borghi SM, Fattori V, Casagrande R et al (2023) New drug targets for the treatment of gout arthritis: what\u2019s new? Expert Opin Ther Targets 27(8):679\u2013703","journal-title":"Expert Opin Ther Targets"},{"key":"10477_CR134","doi-asserted-by":"crossref","first-page":"104673","DOI":"10.1016\/j.micpath.2020.104673","volume":"150","author":"S Choudhary","year":"2021","unstructured":"Choudhary S, Sharma K, Silakari O (2021) The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options. Microb Pathog 150:104673","journal-title":"Microb Pathog"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10477-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10477-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10477-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:31:32Z","timestamp":1766853092000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10477-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":134,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10477"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10477-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"30 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"365"}}