{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T04:07:52Z","timestamp":1794542872012,"version":"4.9.1"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10509-z","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T20:17:15Z","timestamp":1745525835000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chronic inflammation in obesity and neurodegenerative diseases: exploring the link in disease onset and progression"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9825-1026","authenticated-orcid":false,"given":"Yogita","family":"Dhurandhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9910-9300","authenticated-orcid":false,"given":"Shubham","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-0598","authenticated-orcid":false,"given":"Ashmita","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevan Lal","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"As Pee","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-8337","authenticated-orcid":false,"given":"Surendra H.","family":"Bodake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1319-0486","authenticated-orcid":false,"given":"Kamta P.","family":"Namdeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"10509_CR1","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/ONCOTARGET.23208","volume":"9","author":"L Chen","year":"2017","unstructured":"Chen L, Deng H, Cui H et al (2017) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9:7204. https:\/\/doi.org\/10.18632\/ONCOTARGET.23208","journal-title":"Oncotarget"},{"issue":"25","key":"10509_CR2","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"2512","author":"D Furman","year":"2019","unstructured":"Furman D, Campisi J, Verdin E et al (2019) (2019) Chronic inflammation in the etiology of disease across the life span. Nat Med 2512(25):1822\u20131832. https:\/\/doi.org\/10.1038\/s41591-019-0675-0","journal-title":"Nat Med"},{"key":"10509_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/FNCEL.2023.1294420","author":"A Neto","year":"2023","unstructured":"Neto A, Fernandes A, Barateiro A (2023) The complex relationship between obesity and neurodegenerative diseases: an updated review. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/FNCEL.2023.1294420","journal-title":"Front Cell Neurosci"},{"key":"10509_CR4","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.22711","author":"D Khanna","year":"2022","unstructured":"Khanna D, Khanna S, Khanna P et al (2022) Obesity: a chronic low-grade inflammation and its markers. Cureus. https:\/\/doi.org\/10.7759\/CUREUS.22711","journal-title":"Cureus"},{"key":"10509_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2020.604150","author":"AF de Bem","year":"2021","unstructured":"de Bem AF, Krolow R, Farias HR et al (2021) Animal models of metabolic disorders in the study of neurodegenerative diseases: an overview. Front Neurosci. https:\/\/doi.org\/10.3389\/FNINS.2020.604150","journal-title":"Front Neurosci"},{"key":"10509_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/MCO.0B013E3283232A11","volume":"12","author":"AN Margioris","year":"2009","unstructured":"Margioris AN (2009) Fatty acids and postprandial inflammation. Curr Opin Clin Nutr Metab Care 12:129\u2013137. https:\/\/doi.org\/10.1097\/MCO.0B013E3283232A11","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10509_CR7","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005460","author":"PC Calder","year":"2011","unstructured":"Calder PC, Ahluwalia N, Brouns F et al (2011) Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. https:\/\/doi.org\/10.1017\/S0007114511005460","journal-title":"Br J Nutr"},{"key":"10509_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/802078","volume":"2010","author":"CR Balistreri","year":"2010","unstructured":"Balistreri CR, Caruso C, Candore G (2010) The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm 2010:802078. https:\/\/doi.org\/10.1155\/2010\/802078","journal-title":"Mediators Inflamm"},{"key":"10509_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2021.749125","volume":"12","author":"X Yang","year":"2021","unstructured":"Yang X, Zhang X, Yang W et al (2021) Gut microbiota in adipose tissue dysfunction induced cardiovascular disease: role as a metabolic organ. Front Endocrinol (Lausanne) 12:749125. https:\/\/doi.org\/10.3389\/FENDO.2021.749125","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10509_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.5114\/AOMS.2016.58928","volume":"13","author":"MS Ellulu","year":"2016","unstructured":"Ellulu MS, Patimah I, Khaza\u2019ai H, et al (2016) Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci 13:851. https:\/\/doi.org\/10.5114\/AOMS.2016.58928","journal-title":"Arch Med Sci"},{"key":"10509_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S43044-023-00352-7","volume":"75","author":"PK Roy","year":"2023","unstructured":"Roy PK, Islam J (2023) Lalhlenmawia H (2023) Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance. Egypt Hear J 75:1\u201328. https:\/\/doi.org\/10.1186\/S43044-023-00352-7","journal-title":"Egypt Hear J"},{"key":"10509_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01073-0","volume":"7","author":"M Li","year":"2022","unstructured":"Li M, Chi X, Wang Y et al (2022) (2022) Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduct Target Ther 7:1\u201325. https:\/\/doi.org\/10.1038\/s41392-022-01073-0","journal-title":"Signal Transduct Target Ther"},{"key":"10509_CR13","doi-asserted-by":"publisher","first-page":"1221438","DOI":"10.3389\/FNUT.2023.1221438\/PDF","volume":"10","author":"D Das","year":"2023","unstructured":"Das D, Shruthi NR, Banerjee A et al (2023) Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies. Front Nutr 10:1221438. https:\/\/doi.org\/10.3389\/FNUT.2023.1221438\/PDF","journal-title":"Front Nutr"},{"key":"10509_CR14","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/MOH.0B013E3283634443","volume":"20","author":"IO Blokhin","year":"2013","unstructured":"Blokhin IO, Lentz SR (2013) Mechanisms of thrombosis in obesity. Curr Opin Hematol 20:437. https:\/\/doi.org\/10.1097\/MOH.0B013E3283634443","journal-title":"Curr Opin Hematol"},{"key":"10509_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/OBR.13649","volume":"25","author":"FG Scurt","year":"2024","unstructured":"Scurt FG, Ganz MJ, Herzog C et al (2024) Association of metabolic syndrome and chronic kidney disease. Obes Rev 25:e13649. https:\/\/doi.org\/10.1111\/OBR.13649","journal-title":"Obes Rev"},{"key":"10509_CR16","doi-asserted-by":"publisher","first-page":"1158198","DOI":"10.3389\/FCHEM.2023.1158198\/PDF","volume":"11","author":"P Chaudhary","year":"2023","unstructured":"Chaudhary P, Janmeda P, Docea AO et al (2023) Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Front Chem 11:1158198. https:\/\/doi.org\/10.3389\/FCHEM.2023.1158198\/PDF","journal-title":"Front Chem"},{"key":"10509_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.112678","volume":"147","author":"J Geng","year":"2022","unstructured":"Geng J, Ni Q, Sun W et al (2022) The links between gut microbiota and obesity and obesity related diseases. Biomed Pharmacother 147:112678. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.112678","journal-title":"Biomed Pharmacother"},{"key":"10509_CR18","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.119.315897","volume":"126","author":"SP Heffron","year":"2020","unstructured":"Heffron SP, Parham JS, Pendse J, Alem\u00e1n JO (2020) Treatment of obesity in mitigating metabolic risk. Circ Res 126:1646. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.315897","journal-title":"Circ Res"},{"key":"10509_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/J.1365-2249.2006.03261.X","volume":"147","author":"L Ferrero-Miliani","year":"2007","unstructured":"Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE (2007) Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147:227\u2013235. https:\/\/doi.org\/10.1111\/J.1365-2249.2006.03261.X","journal-title":"Clin Exp Immunol"},{"key":"10509_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.5177\/NTVT.2022.03.21138","volume":"129","author":"BGR Zigterman","year":"2022","unstructured":"Zigterman BGR, Dubois L (2022) Inflammation and infection: cellular and biochemical processes. Ned Tijdschr Tandheelkd 129:125\u2013129. https:\/\/doi.org\/10.5177\/NTVT.2022.03.21138","journal-title":"Ned Tijdschr Tandheelkd"},{"key":"10509_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1875041901205010001","volume":"5","author":"V. Stankov S","year":"2012","unstructured":"V. Stankov S (2012) Definition of inflammation, causes of inflammation and possible anti-inflammatory strategies. Open Inflamm J 5:1\u20139. https:\/\/doi.org\/10.2174\/1875041901205010001","journal-title":"Open Inflamm J"},{"key":"10509_CR22","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1136\/PGMJ.53.625.660","volume":"53","author":"TJ Williams","year":"1977","unstructured":"Williams TJ (1977) Oedema and vasodilatation in inflammation: the relevance of prostaglandins. Postgrad Med J 53:660. https:\/\/doi.org\/10.1136\/PGMJ.53.625.660","journal-title":"Postgrad Med J"},{"key":"10509_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS23094928","author":"P Schilrreff","year":"2022","unstructured":"Schilrreff P, Alexiev U (2022) Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment. Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS23094928","journal-title":"Int J Mol Sci"},{"key":"10509_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/206020a0","volume":"206","author":"S Hannoodee","year":"2024","unstructured":"Hannoodee S, Nasuruddin DN (2024) Acute inflammatory response. Nature 206:20. https:\/\/doi.org\/10.1038\/206020a0","journal-title":"Nature"},{"key":"10509_CR25","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/IJMS24010641","volume":"24","author":"AM Soliman","year":"2023","unstructured":"Soliman AM (2023) Barreda DR (2022) Acute inflammation in tissue healing. Int J Mol Sci 24:641. https:\/\/doi.org\/10.3390\/IJMS24010641","journal-title":"Int J Mol Sci"},{"key":"10509_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/PRD.12002","volume":"64","author":"A Cekici","year":"2000","unstructured":"Cekici A, Kantarci A, Hasturk H (2000) Van Dyke TE (2014) Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 64:57\u201380. https:\/\/doi.org\/10.1111\/PRD.12002","journal-title":"Periodontol"},{"key":"10509_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2018.00339","author":"MA Moro-Garc\u00eda","year":"2018","unstructured":"Moro-Garc\u00eda MA, Mayo JC, Sainz RM, Alonso-Arias R (2018) Influence of inflammation in the process of T lymphocyte differentiation: proliferative, metabolic, and oxidative changes. Front Immunol. https:\/\/doi.org\/10.3389\/FIMMU.2018.00339","journal-title":"Front Immunol"},{"key":"10509_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/FIMMU.2016.00160","volume":"7","author":"MA Sugimoto","year":"2016","unstructured":"Sugimoto MA, Sousa LP, Pinho V et al (2016) Resolution of inflammation: what controls its onset? Front Immunol 7:160. https:\/\/doi.org\/10.3389\/FIMMU.2016.00160","journal-title":"Front Immunol"},{"key":"10509_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/978-81-322-2680-2_4","author":"W Ansar","year":"2016","unstructured":"Ansar W, Ghosh S (2016) Inflammation and inflammatory diseases, markers, and mediators: role of CRP in some inflammatory diseases. Biol C React Protein Heal Dis. https:\/\/doi.org\/10.1007\/978-81-322-2680-2_4","journal-title":"Biol C React Protein Heal Dis"},{"key":"10509_CR30","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3390\/BIOM11050700","volume":"11","author":"K Raziyeva","year":"2021","unstructured":"Raziyeva K, Kim Y, Zharkinbekov Z et al (2021) (2021) Immunology of acute and chronic wound healing. Biomol 11:700. https:\/\/doi.org\/10.3390\/BIOM11050700","journal-title":"Biomol"},{"key":"10509_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/LIFE13061420","author":"E Dri","year":"2023","unstructured":"Dri E, Lampas E, Lazaros G et al (2023) Inflammatory mediators of endothelial dysfunction. Life. https:\/\/doi.org\/10.3390\/LIFE13061420","journal-title":"Life"},{"key":"10509_CR32","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.3390\/IJMS20236008","volume":"20","author":"S Kany","year":"2019","unstructured":"Kany S, Vollrath JT (2019) Relja B (2019) Cytokines in inflammatory disease. Int J Mol Sci 20:6008. https:\/\/doi.org\/10.3390\/IJMS20236008","journal-title":"Int J Mol Sci"},{"key":"10509_CR33","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/J.BBAMCR.2014.05.014","volume":"1843","author":"MD Turner","year":"2014","unstructured":"Turner MD, Nedjai B, Hurst T, Pennington DJ (2014) Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta 1843:2563\u20132582. https:\/\/doi.org\/10.1016\/J.BBAMCR.2014.05.014","journal-title":"Biochim Biophys Acta"},{"key":"10509_CR34","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1126\/SCIENCE.294.5548.1871","volume":"294","author":"CD Funk","year":"2001","unstructured":"Funk CD (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294:1871\u20131875. https:\/\/doi.org\/10.1126\/SCIENCE.294.5548.1871","journal-title":"Science"},{"key":"10509_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-72247-5","volume":"10","author":"DR Beers","year":"2020","unstructured":"Beers DR, Zhao W, Neal DW et al (2020) (2020) Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis. Sci Rep 10:1\u201317. https:\/\/doi.org\/10.1038\/s41598-020-72247-5","journal-title":"Sci Rep"},{"key":"10509_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/BIOM12020226","author":"E Ostrycharz","year":"2022","unstructured":"Ostrycharz E, Hukowska-Szematowicz B (2022) New insights into the role of the complement system in human viral diseases. Biomolecules. https:\/\/doi.org\/10.3390\/BIOM12020226","journal-title":"Biomolecules"},{"key":"10509_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/J.IMMUNI.2021.12.013","volume":"55","author":"TV Rohm","year":"2022","unstructured":"Rohm TV, Meier DT, Olefsky JM, Donath MY (2022) Inflammation in obesity, diabetes, and related disorders. Immunity 55:31\u201355. https:\/\/doi.org\/10.1016\/J.IMMUNI.2021.12.013","journal-title":"Immunity"},{"key":"10509_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2019.01607","author":"F Zatterale","year":"2020","unstructured":"Zatterale F, Longo M, Naderi J et al (2020) Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front Physiol. https:\/\/doi.org\/10.3389\/FPHYS.2019.01607","journal-title":"Front Physiol"},{"key":"10509_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2021.111315","volume":"137","author":"B Ahmed","year":"2021","unstructured":"Ahmed B, Sultana R, Greene MW (2021) Adipose tissue and insulin resistance in obese. Biomed Pharmacother 137:111315. https:\/\/doi.org\/10.1016\/J.BIOPHA.2021.111315","journal-title":"Biomed Pharmacother"},{"key":"10509_CR40","doi-asserted-by":"publisher","first-page":"C375","DOI":"10.1152\/AJPCELL.00379.2020","volume":"320","author":"T Kawai","year":"2021","unstructured":"Kawai T, Autieri MV, Scalia R (2021) Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol 320:C375\u2013C391. https:\/\/doi.org\/10.1152\/AJPCELL.00379.2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"10509_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS22094798","author":"G Battineni","year":"2021","unstructured":"Battineni G, Sagaro GG, Chintalapudi N et al (2021) Impact of obesity-induced inflammation on cardiovascular diseases (CVD). Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS22094798","journal-title":"Int J Mol Sci"},{"key":"10509_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2023.1149239","author":"X Zhao","year":"2023","unstructured":"Zhao X, An X, Yang C et al (2023) The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/FENDO.2023.1149239","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10509_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/S12929-016-0303-Y","author":"K Rehman","year":"2016","unstructured":"Rehman K, Akash MSH (2016) Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci. https:\/\/doi.org\/10.1186\/S12929-016-0303-Y","journal-title":"J Biomed Sci"},{"key":"10509_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1530\/JOE-14-0283","volume":"222","author":"M Mraz","year":"2014","unstructured":"Mraz M, Haluzik M (2014) The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 222:113\u2013127. https:\/\/doi.org\/10.1530\/JOE-14-0283","journal-title":"J Endocrinol"},{"key":"10509_CR45","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/CELLS9030706","volume":"9","author":"JHM Yung","year":"2020","unstructured":"Yung JHM, Giacca A (2020) Role of c-Jun N-terminal Kinase (JNK) in obesity and type 2 diabetes. Cells 9:706. https:\/\/doi.org\/10.3390\/CELLS9030706","journal-title":"Cells"},{"key":"10509_CR46","doi-asserted-by":"publisher","first-page":"105905","DOI":"10.1016\/J.ISCI.2022.105905","volume":"26","author":"GG Kang","year":"2022","unstructured":"Kang GG, Trevaskis NL, Murphy AJ, Febbraio MA (2022) Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH. iScience 26:105905. https:\/\/doi.org\/10.1016\/J.ISCI.2022.105905","journal-title":"iScience"},{"key":"10509_CR47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.5493\/WJEM.V13.I3.7","volume":"13","author":"IG Lempesis","year":"2023","unstructured":"Lempesis IG, Georgakopoulou VE (2023) Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus. World J Exp Med 13:7\u201316. https:\/\/doi.org\/10.5493\/WJEM.V13.I3.7","journal-title":"World J Exp Med"},{"key":"10509_CR48","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2119\/2007-00119.TILG","volume":"14","author":"H Tilg","year":"2008","unstructured":"Tilg H, Moschen AR (2008) Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 14:222\u2013231. https:\/\/doi.org\/10.2119\/2007-00119.TILG","journal-title":"Mol Med"},{"key":"10509_CR49","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5803639","author":"K Xiao","year":"2020","unstructured":"Xiao K, Liu C, Tu Z et al (2020) Activation of the NF-\u03baB and MAPK signaling pathways contributes to the inflammatory responses, but not cell injury, in IPEC-1 cells challenged with hydrogen peroxide. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2020\/5803639","journal-title":"Oxid Med Cell Longev"},{"key":"10509_CR50","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/S41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R (2021) NLRP3 inflammasome activation and cell death. Cell Mol Immunol 18:2114. https:\/\/doi.org\/10.1038\/S41423-021-00740-6","journal-title":"Cell Mol Immunol"},{"key":"10509_CR51","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1007\/S00125-012-2644-8","volume":"55","author":"KD Copps","year":"2012","unstructured":"Copps KD, White MF (2012) Regulation of insulin sensitivity by serine\/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55:2565. https:\/\/doi.org\/10.1007\/S00125-012-2644-8","journal-title":"Diabetologia"},{"key":"10509_CR52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/S11154-021-09687-5","volume":"23","author":"C Pic\u00f3","year":"2021","unstructured":"Pic\u00f3 C, Palou M, Pomar CA et al (2021) Leptin as a key regulator of the adipose organ. Rev Endocr Metab Disord 23:13. https:\/\/doi.org\/10.1007\/S11154-021-09687-5","journal-title":"Rev Endocr Metab Disord"},{"key":"10509_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2021.585887","author":"M Obradovic","year":"2021","unstructured":"Obradovic M, Sudar-Milovanovic E, Soskic S et al (2021) Leptin and obesity: role and clinical implication. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/FENDO.2021.585887","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10509_CR54","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.2174\/1389450120666190729120557","volume":"20","author":"H Han","year":"2019","unstructured":"Han H, Zhou W (2019) Leptin and its derivatives: a potential target for autoimmune diseases. Curr Drug Targets 20:1563\u20131571. https:\/\/doi.org\/10.2174\/1389450120666190729120557","journal-title":"Curr Drug Targets"},{"key":"10509_CR55","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2147\/DMSO.S182406","volume":"12","author":"O Gruzdeva","year":"2019","unstructured":"Gruzdeva O, Borodkina D, Uchasova E et al (2019) Leptin resistance: underlying mechanisms and diagnosis. Diabetes Metab Syndr Obes 12:191\u2013198. https:\/\/doi.org\/10.2147\/DMSO.S182406","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10509_CR56","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/ANTIOX12030651","volume":"12","author":"E Maldonado","year":"2023","unstructured":"Maldonado E, Morales-Pison S, Urbina F (2023) Solari A Aging hallmarks and the role of oxidative stress. Antioxidants 12:651. https:\/\/doi.org\/10.3390\/ANTIOX12030651","journal-title":"Antioxidants"},{"key":"10509_CR57","doi-asserted-by":"publisher","first-page":"S368","DOI":"10.1513\/ANNALSATS.201701-042AW","volume":"14","author":"NK Bhatraju","year":"2017","unstructured":"Bhatraju NK, Agrawal A (2017) Mitochondrial dysfunction linking obesity and asthma. Ann Am Thorac Soc 14:S368\u2013S373. https:\/\/doi.org\/10.1513\/ANNALSATS.201701-042AW","journal-title":"Ann Am Thorac Soc"},{"key":"10509_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/ENDOCR\/BQAA017","volume":"161","author":"P Sangwung","year":"2020","unstructured":"Sangwung P, Petersen KF, Shulman GI, Knowles JW (2020) Mitochondrial dysfunction, insulin resistance, and potential genetic implications. Endocrinology 161:1\u201310. https:\/\/doi.org\/10.1210\/ENDOCR\/BQAA017","journal-title":"Endocrinology"},{"key":"10509_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/1389200052997393","volume":"6","author":"M Stuhlinger","year":"2005","unstructured":"Stuhlinger M, Stanger O (2005) Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction. Curr Drug Metab 6:3\u201314. https:\/\/doi.org\/10.2174\/1389200052997393","journal-title":"Curr Drug Metab"},{"key":"10509_CR60","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1089\/MET.2015.0095","volume":"13","author":"P Manna","year":"2015","unstructured":"Manna P, Jain SK (2015) Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord 13:423\u2013444. https:\/\/doi.org\/10.1089\/MET.2015.0095","journal-title":"Metab Syndr Relat Disord"},{"key":"10509_CR61","doi-asserted-by":"publisher","unstructured":"Hanumegowda SM, Venkatappa MM, Gonchigar SJ, Sannaningaiah D (2024) Obesity and Metabolic Syndrome: The Repetitious Disaster of Modern Times. Body Recomposition A Compr Metab Altern to Weight Loss 3\u201342. https:\/\/doi.org\/10.1201\/9781003361473-2\/OBESITY-METABOLIC-SYNDROME-SUJATHA-HANUMEGOWDA-MANJULA-VENKATAPPA-SATHISHA-GONCHIGAR-DEVARAJA-SANNANINGAIAH","DOI":"10.1201\/9781003361473-2\/OBESITY-METABOLIC-SYNDROME-SUJATHA-HANUMEGOWDA-MANJULA-VENKATAPPA-SATHISHA-GONCHIGAR-DEVARAJA-SANNANINGAIAH"},{"key":"10509_CR62","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/NT.0000000000000167","volume":"51","author":"CD Davis","year":"2016","unstructured":"Davis CD (2016) The gut microbiome and its role in obesity. Nutr Today 51:167\u2013174. https:\/\/doi.org\/10.1097\/NT.0000000000000167","journal-title":"Nutr Today"},{"key":"10509_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13073-016-0303-2\/FIGURES\/4","volume":"8","author":"CL Boulang\u00e9","year":"2016","unstructured":"Boulang\u00e9 CL, Neves AL, Chilloux J et al (2016) Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med 8:1\u201312. https:\/\/doi.org\/10.1186\/S13073-016-0303-2\/FIGURES\/4","journal-title":"Genome Med"},{"key":"10509_CR64","doi-asserted-by":"publisher","DOI":"10.1093\/IJNP\/PYW020","author":"P Luczynski","year":"2016","unstructured":"Luczynski P, Neufeld KAMV, Oriach CS et al (2016) Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior. Int J Neuropsychopharmacol. https:\/\/doi.org\/10.1093\/IJNP\/PYW020","journal-title":"Int J Neuropsychopharmacol"},{"key":"10509_CR65","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1093\/ADVANCES\/NMY078","volume":"10","author":"A Cuevas-Sierra","year":"2019","unstructured":"Cuevas-Sierra A, Ramos-Lopez O, Riezu-Boj JI et al (2019) Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications. Adv Nutr 10:S17\u2013S30. https:\/\/doi.org\/10.1093\/ADVANCES\/NMY078","journal-title":"Adv Nutr"},{"key":"10509_CR66","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/J.GENDIS.2020.06.005","volume":"8","author":"MR Zinatizadeh","year":"2021","unstructured":"Zinatizadeh MR, Schock B, Chalbatani GM et al (2021) The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases. Genes Dis 8:287\u2013297. https:\/\/doi.org\/10.1016\/J.GENDIS.2020.06.005","journal-title":"Genes Dis"},{"key":"10509_CR67","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/NRI.2017.52","volume":"17","author":"SC Sun","year":"2017","unstructured":"Sun SC (2017) The non-canonical NF-\u03baB pathway in immunity and inflammation. Nat Rev Immunol 17:545. https:\/\/doi.org\/10.1038\/NRI.2017.52","journal-title":"Nat Rev Immunol"},{"key":"10509_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01149-x","volume":"7","author":"X Wen","year":"2022","unstructured":"Wen X, Zhang B, Wu B et al (2022) (2022) Signaling pathways in obesity: mechanisms and therapeutic interventions. Signal Transduct Target Ther 7:1\u201331. https:\/\/doi.org\/10.1038\/s41392-022-01149-x","journal-title":"Signal Transduct Target Ther"},{"key":"10509_CR69","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0030485","author":"KM Gamber","year":"2012","unstructured":"Gamber KM, Huo L, Ha S et al (2012) Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. PLoS ONE. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0030485","journal-title":"PLoS ONE"},{"key":"10509_CR70","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.3390\/CELLS11244041","volume":"11","author":"LY Huang","year":"2022","unstructured":"Huang LY, Chiu CJ, Hsing CH, Hsu YH (2022) Interferon family cytokines in obesity and insulin sensitivity. Cells 11:4041. https:\/\/doi.org\/10.3390\/CELLS11244041","journal-title":"Cells"},{"key":"10509_CR71","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1161\/CIRCRESAHA.119.315896","volume":"126","author":"H Wu","year":"2020","unstructured":"Wu H, Ballantyne CM (2020) Metabolic inflammation and insulin resistance in obesity. Circ Res 126:1549. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.315896","journal-title":"Circ Res"},{"key":"10509_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41421-020-0167-x","volume":"6","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T (2020) Elinav E (2020) Inflammasome activation and regulation: toward a better understanding of complex mechanisms. Cell Discov 6:1\u201322. https:\/\/doi.org\/10.1038\/s41421-020-0167-x","journal-title":"Cell Discov"},{"key":"10509_CR73","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/S12944-017-0572-9","volume":"16","author":"Z Chen","year":"2017","unstructured":"Chen Z, Yu R, Xiong Y et al (2017) A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease. Lipids Health Dis 16:203. https:\/\/doi.org\/10.1186\/S12944-017-0572-9","journal-title":"Lipids Health Dis"},{"key":"10509_CR74","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/J.MOLCEL.2014.03.029","volume":"54","author":"GR Robbins","year":"2014","unstructured":"Robbins GR, Wen H, Ting JPY (2014) Inflammasomes and metabolic disorders: old genes in modern diseases. Mol Cell 54:297. https:\/\/doi.org\/10.1016\/J.MOLCEL.2014.03.029","journal-title":"Mol Cell"},{"key":"10509_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-024-01954-6","volume":"9","author":"T Hu","year":"2024","unstructured":"Hu T, Liu CH, Lei M et al (2024) (2024) Metabolic regulation of the immune system in health and diseases: mechanisms and interventions. Signal Transduct Target Ther 9:1\u201331. https:\/\/doi.org\/10.1038\/s41392-024-01954-6","journal-title":"Signal Transduct Target Ther"},{"key":"10509_CR76","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/ALN.0B013E3181799D45","volume":"109","author":"JAJ Martyn","year":"2008","unstructured":"Martyn JAJ, Kaneki M, Yasuhara S (2008) Obesity-induced insulin resistance and hyperglycemia: etiological factors and molecular mechanisms. Anesthesiology 109:137. https:\/\/doi.org\/10.1097\/ALN.0B013E3181799D45","journal-title":"Anesthesiology"},{"key":"10509_CR77","doi-asserted-by":"publisher","first-page":"1151185","DOI":"10.3389\/FIMMU.2023.1151185\/PDF","volume":"14","author":"X Zheng","year":"2023","unstructured":"Zheng X, Wan J, Tan G (2023) The mechanisms of NLRP3 inflammasome\/pyroptosis activation and their role in diabetic retinopathy. Front Immunol 14:1151185. https:\/\/doi.org\/10.3389\/FIMMU.2023.1151185\/PDF","journal-title":"Front Immunol"},{"key":"10509_CR78","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3390\/LIFE14070856","volume":"14","author":"I Savulescu-Fiedler","year":"2024","unstructured":"Savulescu-Fiedler I, Mihalcea R, Dragosloveanu S et al (2024) (2024) The interplay between obesity and inflammation. Life 14:856. https:\/\/doi.org\/10.3390\/LIFE14070856","journal-title":"Life"},{"key":"10509_CR79","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1002\/EJHF.2741","volume":"24","author":"G van Woerden","year":"2022","unstructured":"van Woerden G, van Veldhuisen DJ, Westenbrink BD et al (2022) Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives. Eur J Heart Fail 24:2238\u20132250. https:\/\/doi.org\/10.1002\/EJHF.2741","journal-title":"Eur J Heart Fail"},{"key":"10509_CR80","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/ETM.2014.1673","volume":"8","author":"M Motie","year":"2014","unstructured":"Motie M, Evangelista LS, Horwich T et al (2014) Association between inflammatory biomarkers and adiposity in obese patients with heart failure and metabolic syndrome. Exp Ther Med 8:181. https:\/\/doi.org\/10.3892\/ETM.2014.1673","journal-title":"Exp Ther Med"},{"key":"10509_CR81","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1016\/J.NUMECD.2021.05.022","volume":"31","author":"E Gesteiro","year":"2021","unstructured":"Gesteiro E, Meg\u00eda A, Guadalupe-Grau A et al (2021) Early identification of metabolic syndrome risk: A review of reviews and proposal for defining pre-metabolic syndrome status. Nutr Metab Cardiovasc Dis 31:2557\u20132574. https:\/\/doi.org\/10.1016\/J.NUMECD.2021.05.022","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10509_CR82","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-11-25","author":"C den Engelsen","year":"2012","unstructured":"den Engelsen C, Koekkoek PS, Gorter KJ et al (2012) High-sensitivity C-reactive protein to detect metabolic syndrome in a centrally obese population: a cross-sectional analysis. Cardiovasc Diabetol. https:\/\/doi.org\/10.1186\/1475-2840-11-25","journal-title":"Cardiovasc Diabetol"},{"key":"10509_CR83","doi-asserted-by":"publisher","unstructured":"Das K, Barik A, Mitra S, et al (2023) Lean subjects compared to obese with NAFLD have better beta cell function, similar insulin resistance and less fibrosis. https:\/\/doi.org\/10.21203\/RS.3.RS-3463907\/V1","DOI":"10.21203\/RS.3.RS-3463907\/V1"},{"key":"10509_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/J.HNM.2023.200210","volume":"33","author":"S Bansal","year":"2023","unstructured":"Bansal S, Vachher M, Arora T et al (2023) Visceral fat: A key mediator of NAFLD development and progression. Hum Nutr Metab 33:200210. https:\/\/doi.org\/10.1016\/J.HNM.2023.200210","journal-title":"Hum Nutr Metab"},{"key":"10509_CR85","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/FEBS.14389","volume":"286","author":"DT Rutkowski","year":"2019","unstructured":"Rutkowski DT, Rutkowski CDT (2019) Liver function and dysfunction \u2013 a unique window into the physiological reach of ER stress and the unfolded protein response. FEBS J 286:356\u2013378. https:\/\/doi.org\/10.1111\/FEBS.14389","journal-title":"FEBS J"},{"key":"10509_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/FMOLB.2023.1224982","author":"D Patra","year":"2023","unstructured":"Patra D, Banerjee D, Ramprasad P et al (2023) Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes. Front Mol Biosci. https:\/\/doi.org\/10.3389\/FMOLB.2023.1224982","journal-title":"Front Mol Biosci"},{"key":"10509_CR87","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/MD.0B013E3182779D49","volume":"91","author":"ZM Younossi","year":"2012","unstructured":"Younossi ZM, Stepanova M, Negro F et al (2012) Nonalcoholic fatty liver disease in lean individuals in the United States. Medicine (Baltimore) 91:319\u2013327. https:\/\/doi.org\/10.1097\/MD.0B013E3182779D49","journal-title":"Medicine (Baltimore)"},{"key":"10509_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/METABO13010086","author":"LO Schmitt","year":"2023","unstructured":"Schmitt LO, Gaspar JM (2023) Obesity-induced brain neuroinflammatory and mitochondrial changes. Metabolites. https:\/\/doi.org\/10.3390\/METABO13010086","journal-title":"Metabolites"},{"key":"10509_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.795089","author":"MA Olude","year":"2022","unstructured":"Olude MA, Mouihate A, Mustapha OA et al (2022) Astrocytes and microglia in stress-induced neuroinflammation: the African perspective. Front Immunol. https:\/\/doi.org\/10.3389\/FIMMU.2022.795089","journal-title":"Front Immunol"},{"key":"10509_CR90","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/JCM14020386","volume":"14","author":"S Kim","year":"2025","unstructured":"Kim S, Jung UJ (2025) Kim SR The crucial role of the blood-brain barrier in neurodegenerative diseases: mechanisms of disruption and therapeutic implications. J Clin Med 14:386. https:\/\/doi.org\/10.3390\/JCM14020386","journal-title":"J Clin Med"},{"key":"10509_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ANTIOX9080743","volume":"9","author":"DSA Simpson","year":"2020","unstructured":"Simpson DSA, Oliver PL (2020) ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants (Basel, Switzerland) 9:1\u201327. https:\/\/doi.org\/10.3390\/ANTIOX9080743","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10509_CR92","doi-asserted-by":"publisher","DOI":"10.3390\/BRAINSCI13121610","author":"P Marzola","year":"2023","unstructured":"Marzola P, Melzer T, Pavesi E et al (2023) Exploring the role of neuroplasticity in development, aging, and neurodegeneration. Brain Sci. https:\/\/doi.org\/10.3390\/BRAINSCI13121610","journal-title":"Brain Sci"},{"key":"10509_CR93","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.2337\/DB14-0052","volume":"63","author":"B Omar","year":"2014","unstructured":"Omar B, Ahr\u00e9n B (2014) Pleiotropic mechanisms for the glucose-lowering action of DPP-4 inhibitors. Diabetes 63:2196\u20132202. https:\/\/doi.org\/10.2337\/DB14-0052","journal-title":"Diabetes"},{"key":"10509_CR94","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/J.CMET.2023.11.009","volume":"36","author":"CK Wong","year":"2024","unstructured":"Wong CK, McLean BA, Baggio LL et al (2024) Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation. Cell Metab 36:130. https:\/\/doi.org\/10.1016\/J.CMET.2023.11.009","journal-title":"Cell Metab"},{"key":"10509_CR95","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.2147\/JIR.S436147","volume":"16","author":"H Lin","year":"2023","unstructured":"Lin H, Ao H, Guo G, Liu M (2023) The role and mechanism of metformin in inflammatory diseases. J Inflamm Res 16:5545. https:\/\/doi.org\/10.2147\/JIR.S436147","journal-title":"J Inflamm Res"},{"key":"10509_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJMCR.2024.100160","volume":"11","author":"S Basak","year":"2024","unstructured":"Basak S, Murmu A, Matore BW et al (2024) Thiazolidinedione an auspicious scaffold as PPAR-\u03b3 agonist: its possible mechanism to Manoeuvre against insulin resistant diabetes mellitus. Eur J Med Chem Reports 11:100160. https:\/\/doi.org\/10.1016\/J.EJMCR.2024.100160","journal-title":"Eur J Med Chem Reports"},{"key":"10509_CR97","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2017.00809\/BIBTEX","volume":"8","author":"R Cant","year":"2017","unstructured":"Cant R, Dalgleish AG, Allen RL (2017) Naltrexone inhibits IL-6 and TNF\u03b1 production in human immune cell subsets following stimulation with ligands for intracellular toll-like receptors. Front Immunol 8:249153. https:\/\/doi.org\/10.3389\/FIMMU.2017.00809\/BIBTEX","journal-title":"Front Immunol"},{"key":"10509_CR98","doi-asserted-by":"publisher","first-page":"114","DOI":"10.2174\/1573408014666171220152537\/CITE\/REFWORKS","volume":"14","author":"JF Lula","year":"2018","unstructured":"Lula JF, de Paula MB, A, Guimaraes AL et al (2018) Cox enzyme inhibitor, celecoxib, reduces steatosis and liver lipogenesis in high-fat fed mice. Curr Enzym Inhib 14:114\u2013119. https:\/\/doi.org\/10.2174\/1573408014666171220152537\/CITE\/REFWORKS","journal-title":"Curr Enzym Inhib"},{"key":"10509_CR99","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/J.METABOL.2009.08.011","volume":"59","author":"DT Furuya","year":"2010","unstructured":"Furuya DT, Poletto AC, Favaro RR et al (2010) Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate\u2013treated obese mice. Metabolism 59:395\u2013399. https:\/\/doi.org\/10.1016\/J.METABOL.2009.08.011","journal-title":"Metabolism"},{"key":"10509_CR100","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/HR.2010.1","volume":"33","author":"JF Ndisang","year":"2010","unstructured":"Ndisang JF, Jadhav A (2010) Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats. Hypertens Res 33:338\u2013347. https:\/\/doi.org\/10.1038\/HR.2010.1","journal-title":"Hypertens Res"},{"key":"10509_CR101","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0273942","volume":"17","author":"SS da Cruz Nascimento","year":"2022","unstructured":"da Cruz Nascimento SS, de Queiroz JLC, de Medeiros AF et al (2022) Anti-inflammatory agents as modulators of the inflammation in adipose tissue: A systematic review. PLoS ONE 17:e0273942. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0273942","journal-title":"PLoS ONE"},{"key":"10509_CR102","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/S40360-020-0385-8","volume":"21","author":"M Alsaggar","year":"2020","unstructured":"Alsaggar M, Bdour S, Ababneh Q et al (2020) Silibinin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model in mice. BMC Pharmacol Toxicol 21:8. https:\/\/doi.org\/10.1186\/S40360-020-0385-8","journal-title":"BMC Pharmacol Toxicol"},{"key":"10509_CR103","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/S13668-024-00548-6\/FIGURES\/2","volume":"13","author":"JS Volek","year":"2024","unstructured":"Volek JS, Kackley ML, Buga A (2024) Nutritional considerations during major weight loss therapy: focus on optimal protein and a low-carbohydrate dietary pattern. Curr Nutr Rep 13:422\u2013443. https:\/\/doi.org\/10.1007\/S13668-024-00548-6\/FIGURES\/2","journal-title":"Curr Nutr Rep"},{"key":"10509_CR104","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.3390\/IJERPH17114135","volume":"17","author":"D Margin\u0103","year":"2020","unstructured":"Margin\u0103 D, Ungurianu A, Purdel C et al (2020) Chronic inflammation in the context of everyday life: dietary changes as mitigating factors. Int J Environ Res Public Health 17:4135. https:\/\/doi.org\/10.3390\/IJERPH17114135","journal-title":"Int J Environ Res Public Health"},{"key":"10509_CR105","doi-asserted-by":"publisher","first-page":"20","DOI":"10.7570\/JOMES20065","volume":"30","author":"JY Kim","year":"2020","unstructured":"Kim JY (2020) Optimal diet strategies for weight loss and weight loss maintenance. J Obes Metab Syndr 30:20. https:\/\/doi.org\/10.7570\/JOMES20065","journal-title":"J Obes Metab Syndr"},{"key":"10509_CR106","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/J.JACC.2018.08.1037","volume":"72","author":"CJ Lavie","year":"2018","unstructured":"Lavie CJ, Laddu D, Arena R et al (2018) Healthy weight and obesity prevention: JACC health promotion series. J Am Coll Cardiol 72:1506\u20131531. https:\/\/doi.org\/10.1016\/J.JACC.2018.08.1037","journal-title":"J Am Coll Cardiol"},{"key":"10509_CR107","doi-asserted-by":"publisher","first-page":"165823","DOI":"10.1016\/J.BBADIS.2020.165823","volume":"1866","author":"D da Scheffer","year":"2020","unstructured":"da Scheffer D, L, Latini A, (2020) Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs. Biochim Biophys acta Mol Basis Dis 1866:165823\u2013165823. https:\/\/doi.org\/10.1016\/J.BBADIS.2020.165823","journal-title":"Biochim Biophys acta Mol Basis Dis"},{"key":"10509_CR108","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2337\/DS17-0013","volume":"30","author":"CE Cox","year":"2017","unstructured":"Cox CE (2017) Role of physical activity for weight loss and weight maintenance. Diabetes Spectr 30:157. https:\/\/doi.org\/10.2337\/DS17-0013","journal-title":"Diabetes Spectr"},{"key":"10509_CR109","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/J.BCP.2019.03.030","volume":"165","author":"V Francisco","year":"2019","unstructured":"Francisco V, Ruiz-Fern\u00e1ndez C, Pino J et al (2019) Adipokines: Linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol 165:196\u2013206. https:\/\/doi.org\/10.1016\/J.BCP.2019.03.030","journal-title":"Biochem Pharmacol"},{"key":"10509_CR110","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1089\/JIR.2013.0078","volume":"34","author":"C Shi","year":"2014","unstructured":"Shi C, Zhu L, Chen X et al (2014) IL-6 and TNF-\u03b1 induced obesity-related inflammatory response through transcriptional regulation of miR-146b. J Interf Cytokine Res 34:342. https:\/\/doi.org\/10.1089\/JIR.2013.0078","journal-title":"J Interf Cytokine Res"},{"key":"10509_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/BIOLOGY11030372","author":"A Roberti","year":"2022","unstructured":"Roberti A, Chaffey LE, Greaves DR (2022) NF-\u03baB signaling and inflammation-drug repurposing to treat inflammatory disorders? Biology (Basel). https:\/\/doi.org\/10.3390\/BIOLOGY11030372","journal-title":"Biology (Basel)"},{"key":"10509_CR112","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/JIR.S344071","volume":"15","author":"Z Wang","year":"2022","unstructured":"Wang Z, Xu G, Li Z et al (2022) NLRP3 inflammasome pharmacological inhibitors in glycyrrhiza for NLRP3-driven diseases treatment: Extinguishing the fire of inflammation. J Inflamm Res 15:409. https:\/\/doi.org\/10.2147\/JIR.S344071","journal-title":"J Inflamm Res"},{"key":"10509_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/J.XCRM.2021.100396","volume":"2","author":"B Trinh","year":"2021","unstructured":"Trinh B, Peletier M, Simonsen C et al (2021) Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men. Cell Reports Med 2:100396. https:\/\/doi.org\/10.1016\/J.XCRM.2021.100396","journal-title":"Cell Reports Med"},{"key":"10509_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.112678","author":"J Geng","year":"2022","unstructured":"Geng J, Ni Q, Sun W et al (2022) The links between gut microbiota and obesity and obesity related diseases. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.112678","journal-title":"Biomed Pharmacother"},{"key":"10509_CR115","doi-asserted-by":"publisher","first-page":"95974","DOI":"10.1155\/2007\/95974","volume":"2007","author":"R Stienstra","year":"2006","unstructured":"Stienstra R, Duval C, M\u00fcller M, Kersten S (2006) PPARs, obesity, and inflammation. PPAR Res 2007:95974. https:\/\/doi.org\/10.1155\/2007\/95974","journal-title":"PPAR Res"},{"key":"10509_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPS.2025.107002","author":"EA Elmorsy","year":"2025","unstructured":"Elmorsy EA, Elsisi HA, Alkhamiss AS et al (2025) Activation of SIRT1 by SRT1720 alleviates dyslipidemia, improves insulin sensitivity and exhibits liver-protective effects in diabetic rats on a high-fat diet: New insights into the SIRT1\/Nrf2\/NF\u03baB signaling pathway. Eur J Pharm Sci. https:\/\/doi.org\/10.1016\/J.EJPS.2025.107002","journal-title":"Eur J Pharm Sci"},{"key":"10509_CR117","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3390\/NU17020302","volume":"17","author":"B Mengoni","year":"2025","unstructured":"Mengoni B, Armeli F, Schifano E et al (2025) (2025) In Vitro and In Vivo antioxidant and immune stimulation activity of wheat product extracts. Nutr 17:302. https:\/\/doi.org\/10.3390\/NU17020302","journal-title":"Nutr"},{"key":"10509_CR118","doi-asserted-by":"publisher","first-page":"6868","DOI":"10.3390\/CIMB46070410","volume":"46","author":"F Armeli","year":"2024","unstructured":"Armeli F, Mengoni B, Laskin DL, Businaro R (2024) Interplay among oxidative stress, autophagy, and the endocannabinoid system in neurodegenerative diseases: Role of the Nrf2- p62\/SQSTM1 pathway and nutraceutical activation. Curr Issues Mol Biol 46:6868\u20136884. https:\/\/doi.org\/10.3390\/CIMB46070410","journal-title":"Curr Issues Mol Biol"},{"key":"10509_CR119","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2020.00116\/BIBTEX","volume":"13","author":"MA Hannan","year":"2020","unstructured":"Hannan MA, Dash R, Sohag AAM et al (2020) Neuroprotection against oxidative stress: phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system. Front Mol Neurosci 13:537460. https:\/\/doi.org\/10.3389\/FNMOL.2020.00116\/BIBTEX","journal-title":"Front Mol Neurosci"},{"key":"10509_CR120","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2022.843105\/BIBTEX","volume":"16","author":"TS Webberley","year":"2022","unstructured":"Webberley TS, Masetti G, Bevan RJ et al (2022) The impact of probiotic supplementation on cognitive, pathological and metabolic markers in a transgenic mouse model of Alzheimer\u2019s Disease. Front Neurosci 16:843105. https:\/\/doi.org\/10.3389\/FNINS.2022.843105\/BIBTEX","journal-title":"Front Neurosci"},{"key":"10509_CR121","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES10123116","author":"F Armeli","year":"2022","unstructured":"Armeli F, Mengoni B, Maggi E et al (2022) Milmed yeast alters the LPS-induced M1 microglia cells to form M2 anti-inflammatory phenotype. Biomedicines. https:\/\/doi.org\/10.3390\/BIOMEDICINES10123116","journal-title":"Biomedicines"},{"key":"10509_CR122","doi-asserted-by":"publisher","DOI":"10.1002\/CTI2.1394","volume":"11","author":"K Li","year":"2022","unstructured":"Li K, Ly K, Mehta S, Braithwaite A (2022) Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clin Transl Immunol 11:e1394. https:\/\/doi.org\/10.1002\/CTI2.1394","journal-title":"Clin Transl Immunol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10509-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10509-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10509-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:30:39Z","timestamp":1766853039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10509-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":122,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10509"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10509-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors read and approved the manuscript, and the manuscript has not been submitted elsewhere nor published in whole or in part.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving Human and Animal Rights"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"424"}}