{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:11:15Z","timestamp":1788448275880,"version":"build-2803163510"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10579-z","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T13:09:05Z","timestamp":1747919345000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-infertility roles of flavonoids: insights into the female reproductive system"],"prefix":"10.1007","volume":"52","author":[{"given":"Morteza","family":"Abdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Karimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirreza","family":"Jourabchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Khameneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abedelahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"issue":"1","key":"10579_CR1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12958-023-01054-0","volume":"21","author":"A Szab\u00f3","year":"2023","unstructured":"Szab\u00f3 A, V\u00e1ncsa S, Hegyi P, V\u00e1radi A, Forintos A, Filipov T et al (2023) Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis. Reprod Biol Endocrinol 21(1):5","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"10579_CR2","first-page":"208","volume":"28","author":"WHO","year":"2023","unstructured":"WHO (2023) 1 in 6 people globally affected by infertility. Neurosciences (Riyadh, Saudi Arabia) 28(3):208","journal-title":"Neurosciences (Riyadh, Saudi Arabia)"},{"key":"10579_CR3","doi-asserted-by":"publisher","DOI":"10.1159\/000542408","author":"D Shen","year":"2024","unstructured":"Shen D, Yang S, Qi C, Yang H (2024) Global, regional, and national prevalence and disability-adjusted life-years for female infertility: Results from a global burden of disease study, 1990\u20132019. Gynecol Obstet Invest. https:\/\/doi.org\/10.1159\/000542408","journal-title":"Gynecol Obstet Invest"},{"issue":"10","key":"10579_CR4","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.3346\/jkms.2024.39.e85","volume":"39","author":"J Lee","year":"2024","unstructured":"Lee J, Choo CW, Moon KY, Lyu SW, Kim H, Lee JY et al (2024) Risk factors for infertility in Korean WOMEN. J Korean Med Sci 39(10):e85","journal-title":"J Korean Med Sci"},{"issue":"3","key":"10579_CR5","doi-asserted-by":"crossref","first-page":"e057132","DOI":"10.1136\/bmjopen-2021-057132","volume":"12","author":"NH Nik Hazlina","year":"2022","unstructured":"Nik Hazlina NH, Norhayati MN, Shaiful Bahari I, Nik Muhammad Arif NA (2022) Worldwide prevalence, risk factors and psychological impact of infertility among women: a systematic review and meta-analysis. BMJ Open 12(3):e057132","journal-title":"BMJ Open"},{"issue":"2","key":"10579_CR6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/87564793211052023","volume":"38","author":"HI Kanwal","year":"2021","unstructured":"Kanwal HI, Shahid M, Bacha R (2021) Sonographic evaluation of various causes of female infertility: a literature review. J Diagn Med Sonogr 38(2):155\u2013159","journal-title":"J Diagn Med Sonogr"},{"key":"10579_CR7","unstructured":"Nikas SA, Musale P, Ganu R (2024) A comprehensive approach to anovulation: a review. 13(22): 280\u2013289"},{"issue":"4","key":"10579_CR8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3390\/pr8040434","volume":"8","author":"ML Ch\u00e1vez-Gonz\u00e1lez","year":"2020","unstructured":"Ch\u00e1vez-Gonz\u00e1lez ML, Sep\u00falveda L, Verma DK, Luna-Garc\u00eda HA, Rodr\u00edguez-Dur\u00e1n LV, Ilina A, Aguilar CN (2020) Conventional and emerging extraction processes of flavonoids. Processes 8(4):434","journal-title":"Processes"},{"key":"10579_CR9","doi-asserted-by":"crossref","first-page":"1065243","DOI":"10.3389\/fphar.2022.1065243","volume":"13","author":"E-D Luo","year":"2023","unstructured":"Luo E-D, Jiang H-M, Chen W, Wang Y, Tang M, Guo WM et al (2023) Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: a review. Front Pharmacol 13:1065243","journal-title":"Front Pharmacol"},{"key":"10579_CR10","first-page":"1","volume":"32","author":"Y Chen","year":"2024","unstructured":"Chen Y, Wang S, Zhang C (2024) The differentiation fate of granulosa cells and the regulatory mechanism in ovary. Reprod Sci 32:1\u201313","journal-title":"Reprod Sci"},{"issue":"6","key":"10579_CR11","doi-asserted-by":"crossref","first-page":"e70014","DOI":"10.1111\/aji.70014","volume":"92","author":"M Abdi","year":"2024","unstructured":"Abdi M, Fadaee M, Jourabchi A, Karimzadeh H, Kazemi T (2024) Cyclophosphamide-induced infertility and the impact of antioxidants. Am J Reprod Immunol 92(6):e70014","journal-title":"Am J Reprod Immunol"},{"key":"10579_CR12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-981-19-8848-6_2","volume-title":"The life cycle of the ovary. Ovarian aging","author":"L Ma","year":"2023","unstructured":"Ma L, Shen W, Zhang J, Ma L, Shen W, Shen W et al (2023) The life cycle of the ovary. Ovarian aging. Springer, Cham, pp 7\u201333"},{"key":"10579_CR13","first-page":"9","volume-title":"Reactive oxygen species in the reproductive system: sources and physiological roles. Oxidative stress and toxicity in reproductive biology and medicine: a comprehensive update on male infertility-volume one","author":"A Das","year":"2022","unstructured":"Das A, Roychoudhury S (2022) Reactive oxygen species in the reproductive system: sources and physiological roles. Oxidative stress and toxicity in reproductive biology and medicine: a comprehensive update on male infertility-volume one. Springer, Cham, pp 9\u201340"},{"key":"10579_CR14","doi-asserted-by":"crossref","first-page":"102659","DOI":"10.1016\/j.redox.2023.102659","volume":"62","author":"J Liang","year":"2023","unstructured":"Liang J, Gao Y, Feng Z, Zhang B, Na Z, Li D (2023) Reactive oxygen species and ovarian diseases: antioxidant strategies. Redox Biol 62:102659","journal-title":"Redox Biol"},{"key":"10579_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5316984","author":"F Tim\u00f3teo-Ferreira","year":"2019","unstructured":"Tim\u00f3teo-Ferreira F, Mendes S, Rocha N, Matos L, Rodrigues A, Almeida H, Silva E (2019) Apocynin dietary supplementation delays mouse ovarian ageing. Oxid Med Cell Long. https:\/\/doi.org\/10.1155\/2019\/5316984","journal-title":"Oxid Med Cell Long"},{"key":"10579_CR16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","volume":"77","author":"E Barati","year":"2020","unstructured":"Barati E, Nikzad H, Karimian M (2020) Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Cell Mol Life Sci 77:93\u2013113","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10579_CR17","doi-asserted-by":"crossref","first-page":"F109","DOI":"10.1530\/REP-22-0206","volume":"164","author":"JH Martin","year":"2022","unstructured":"Martin JH, Nixon B, Cafe SL, Aitken RJ, Bromfield EG, Lord T (2022) Oxidative stress and reproductive function: oxidative stress and in vitro ageing of the post-ovulatory oocyte: an update on recent advances in the field. Reproduction 164(6):F109\u2013F124","journal-title":"Reproduction"},{"issue":"1","key":"10579_CR18","doi-asserted-by":"crossref","first-page":"e16166","DOI":"10.1111\/jog.16166","volume":"51","author":"H Kobayashi","year":"2025","unstructured":"Kobayashi H, Imanaka S (2025) Exploring potential pathways from oxidative stress to ovarian aging. J Obstet Gynaecol Res 51(1):e16166","journal-title":"J Obstet Gynaecol Res"},{"key":"10579_CR19","doi-asserted-by":"crossref","first-page":"685724","DOI":"10.3389\/fimmu.2021.685724","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, Liu H, Li Z, Fan H, Yan X, Liu X et al (2021) The release of peripheral immune inflammatory cytokines promote an inflammatory cascade in PCOS patients via altering the follicular microenvironment. Front Immunol 12:685724","journal-title":"Front Immunol"},{"key":"10579_CR20","doi-asserted-by":"crossref","first-page":"1136705","DOI":"10.3389\/fvets.2023.1136705","volume":"10","author":"S Kim","year":"2023","unstructured":"Kim S, Oh D, Choi H, Kim M, Cai L, Jawad A et al (2023) The effect of C-C motif chemokine ligand 2 supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation. Front Veterin Sci 10:1136705","journal-title":"Front Veterin Sci"},{"issue":"2","key":"10579_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/biom12020231","volume":"12","author":"H Wu","year":"2022","unstructured":"Wu H, Zhu R, Zheng B, Liao G, Wang F, Ding J et al (2022) Single-cell sequencing reveals an intrinsic heterogeneity of the preovulatory follicular microenvironment. Biomolecules 12(2):231","journal-title":"Biomolecules"},{"key":"10579_CR22","doi-asserted-by":"crossref","first-page":"1297484","DOI":"10.3389\/fimmu.2023.1297484","volume":"14","author":"L Qi","year":"2023","unstructured":"Qi L, Li Y, Zhang L, Li S, Zhang X, Li W et al (2023) Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptome. Front Immunol 14:1297484","journal-title":"Front Immunol"},{"issue":"1","key":"10579_CR23","doi-asserted-by":"crossref","first-page":"e12619","DOI":"10.1002\/rmb2.12619","volume":"23","author":"Y Negishi","year":"2024","unstructured":"Negishi Y, Morita R (2024) Inflammatory responses in early pregnancy: physiological and pathological perspectives. Reprod Med Biol 23(1):e12619","journal-title":"Reprod Med Biol"},{"key":"10579_CR24","volume-title":"Importance of oxidative stress mechanism in reproductive functions and infertility. Importance of oxidative stress and antioxidant system in health and disease","author":"MC Onaolapo","year":"2022","unstructured":"Onaolapo MC, Nzekwe SC, Olabisi LO, Amos VO, Ajayi OH, Ajayi AF (2022) Importance of oxidative stress mechanism in reproductive functions and infertility. Importance of oxidative stress and antioxidant system in health and disease. IntechOpen, London"},{"issue":"7","key":"10579_CR25","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3390\/antiox11071335","volume":"11","author":"V Immediata","year":"2022","unstructured":"Immediata V, Ronchetti C, Spadaro D, Cirillo F, Levi-Setti PE (2022) Oxidative stress and human ovarian response\u2014from somatic ovarian cells to oocytes damage: a clinical comprehensive narrative review. Antioxidants 11(7):1335","journal-title":"Antioxidants"},{"issue":"1","key":"10579_CR26","doi-asserted-by":"crossref","first-page":"22623","DOI":"10.1038\/s41598-024-72434-8","volume":"14","author":"Y Shao","year":"2024","unstructured":"Shao Y, Ma L, Zhou J, Wu K, Tang X (2024) Impact of dietary antioxidants on female infertility risk: evidence from NHANES. Sci Rep 14(1):22623","journal-title":"Sci Rep"},{"issue":"8","key":"10579_CR27","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/jpm13081264","volume":"13","author":"I Zaha","year":"2023","unstructured":"Zaha I, Muresan M, Tulcan C, Huniadi A, Naghi P, Sandor M et al (2023) The role of oxidative stress in infertility. J Personal Med 13(8):1264","journal-title":"J Personal Med"},{"issue":"1","key":"10579_CR28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12958-024-01273-z","volume":"22","author":"X Xu","year":"2024","unstructured":"Xu X, Wang Z, Lv L, Liu C, Wang L, Sun YN et al (2024) Molecular regulation of DNA damage and repair in female infertility: a systematic review. Reprod Biol Endocrinol 22(1):103","journal-title":"Reprod Biol Endocrinol"},{"issue":"8","key":"10579_CR29","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3390\/antiox12081490","volume":"12","author":"A Kaltsas","year":"2023","unstructured":"Kaltsas A, Zikopoulos A, Moustakli E, Zachariou A, Tsirka G, Tsiampali C et al (2023) The silent threat to women\u2019s fertility: uncovering the devastating effects of oxidative stress. Antioxidants 12(8):1490","journal-title":"Antioxidants"},{"issue":"13","key":"10579_CR30","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.3390\/ijms22137138","volume":"22","author":"L Cacciottola","year":"2021","unstructured":"Cacciottola L, Donnez J, Dolmans MM (2021) Can endometriosis-related oxidative stress pave the way for new treatment targets? Int J Mol Sci 22(13):7138","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10579_CR31","first-page":"61","volume":"22","author":"O Adeoye","year":"2018","unstructured":"Adeoye O, Olawumi J, Opeyemi A, Christiania O (2018) Review on the role of glutathione on oxidative stress and infertility. JBRA Assist Reprod 22(1):61\u201366","journal-title":"JBRA Assist Reprod"},{"key":"10579_CR32","doi-asserted-by":"publisher","DOI":"10.20959\/wjpr202419-33966","author":"S Gayathri","year":"2024","unstructured":"Gayathri S, Khaviya M, Devika M, Heeshan Raju R, Sri Ramcharan P (2024) Impact of modern life style, environment and age on female fertility. World J Pharm Res. https:\/\/doi.org\/10.20959\/wjpr202419-33966","journal-title":"World J Pharm Res"},{"key":"10579_CR33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-030-04624-8_13","volume-title":"Polyphenols and flavonoids. Nutraceuticals in veterinary medicine","author":"SK Garg","year":"2019","unstructured":"Garg SK, Shukla A, Choudhury S (2019) Polyphenols and flavonoids. Nutraceuticals in veterinary medicine. Springer, Cham, pp 187\u2013204"},{"issue":"13","key":"10579_CR34","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1021\/acsomega.0c06156","volume":"6","author":"SA de Souza Farias","year":"2021","unstructured":"de Souza Farias SA, da Costa KS, Martins JBL (2021) Analysis of conformational, structural, magnetic, and electronic properties related to antioxidant activity: revisiting flavan, anthocyanidin, flavanone, flavonol, isoflavone, flavone, and flavan-3-ol. ACS Omega 6(13):8908\u20138918","journal-title":"ACS Omega"},{"issue":"2","key":"10579_CR35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s43188-020-00080-z","volume":"37","author":"S Safe","year":"2021","unstructured":"Safe S, Jayaraman A, Chapkin RS, Howard M, Mohankumar K, Shrestha R (2021) Flavonoids: structure\u2013function and mechanisms of action and opportunities for drug development. Toxicol Res 37(2):147\u2013162","journal-title":"Toxicol Res"},{"key":"10579_CR36","doi-asserted-by":"crossref","first-page":"113945","DOI":"10.1016\/j.biopha.2022.113945","volume":"156","author":"A Rakha","year":"2022","unstructured":"Rakha A, Umar N, Rabail R, Butt MS, Kieliszek M, Hassoun A, Aadil RM (2022) Anti-inflammatory and anti-allergic potential of dietary flavonoids: a review. Biomed Pharmacother 156:113945","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"10579_CR37","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/agronomy10081209","volume":"10","author":"A Shah","year":"2020","unstructured":"Shah A, Smith DL (2020) Flavonoids in agriculture: chemistry and roles in, biotic and abiotic stress responses, and microbial associations. Agronomy 10(8):1209","journal-title":"Agronomy"},{"issue":"1","key":"10579_CR38","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/ijms22010470","volume":"22","author":"TH Pham","year":"2021","unstructured":"Pham TH, Page YL, Percevault F, Ferri\u00e8re F, Flouriot G, Pakdel F (2021) Apigenin, a partial antagonist of the estrogen receptor (ER), inhibits ER-positive breast cancer cell proliferation through Akt\/FOXM1 signaling. Int J Mol Sci 22(1):470","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10579_CR39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12672-018-0333-x","volume":"9","author":"M Dean","year":"2018","unstructured":"Dean M, Austin J, Jinhong R, Johnson ME, Lantvit DD, Burdette JE (2018) The flavonoid apigenin is a progesterone receptor modulator with in vivo activity in the uterus. Horm Cancer 9(4):265\u2013277","journal-title":"Horm Cancer"},{"issue":"3","key":"10579_CR40","first-page":"261","volume":"57","author":"BS Kumar","year":"2023","unstructured":"Kumar BS, Manasa V, Ramesh H, Nandi S, Kumar VG (2023) Molecular targets of phyto-bioactive compounds in female reproductive system of mammals: a review. Indian J Anim Res 57(3):261\u2013272","journal-title":"Indian J Anim Res"},{"issue":"3","key":"10579_CR41","first-page":"257","volume":"12","author":"M Safari","year":"2018","unstructured":"Safari M, Parsaie H, Sameni HR, Aldaghi MR, Zarbakhsh S (2018) Anti-oxidative and anti-apoptotic effects of apigenin on number of viable and apoptotic blastomeres, zona pellucida thickness and hatching rate of mouse embryos. Int J Fert Steril 12(3):257","journal-title":"Int J Fert Steril"},{"issue":"2","key":"10579_CR42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.18621\/eurj.1209679","volume":"9","author":"G Hekimo\u011flu","year":"2023","unstructured":"Hekimo\u011flu G, Ko\u00e7 S, Da\u015ftan A\u0130, \u015eevgin K, Tekayev M, G\u00fcler EM et al (2023) Ameliorative effects of apigenin on a rat model of endometriosis. Eur Res J 9(2):178\u2013185","journal-title":"Eur Res J"},{"key":"10579_CR43","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3389\/fphar.2020.01046","volume":"11","author":"L Yao","year":"2020","unstructured":"Yao L, Fan Z, Han S, Sun N, Che H (2020) Apigenin attenuates the allergic reactions by competitively binding to ER with estradiol. Front Pharmacol 11:1046","journal-title":"Front Pharmacol"},{"issue":"1","key":"10579_CR44","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1080\/10942912.2023.2236329","volume":"26","author":"Z Mushtaq","year":"2023","unstructured":"Mushtaq Z, Sadeer NB, Hussain M, Mahwish ASA, Imran M et al (2023) Therapeutical properties of apigenin: A review on the experimental evidence and basic mechanisms. Int J Food Prop 26(1):1914\u20131939","journal-title":"Int J Food Prop"},{"issue":"8","key":"10579_CR45","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3390\/antiox13080922","volume":"13","author":"M Zahra","year":"2024","unstructured":"Zahra M, Abrahamse H, George BP (2024) Flavonoids: antioxidant powerhouses and their role in nanomedicine. Antioxidants 13(8):922","journal-title":"Antioxidants"},{"issue":"4","key":"10579_CR46","doi-asserted-by":"crossref","first-page":"e13964","DOI":"10.1111\/ppl.13964","volume":"175","author":"B Arikan","year":"2023","unstructured":"Arikan B, Yildiztugay E, Ozfidan-Konakci C (2023) Protective role of quercetin and kaempferol against oxidative damage and photosynthesis inhibition in wheat chloroplasts under arsenic stress. Physiol Plant 175(4):e13964","journal-title":"Physiol Plant"},{"issue":"8","key":"10579_CR47","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.3390\/nu15081888","volume":"15","author":"M Al-Zharani","year":"2023","unstructured":"Al-Zharani M, Mubarak M, Rudayni HA, Al-Doaiss AA, Abd-Elwahab MM, Al-Eissa MS (2023) Quercetin as a dietary supplementary flavonoid alleviates the oxidative stress induced by lead toxicity in male wistar rats. Nutrients 15(8):1888","journal-title":"Nutrients"},{"issue":"9","key":"10579_CR48","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.3390\/molecules27092901","volume":"27","author":"JM Al-Khayri","year":"2022","unstructured":"Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ (2022) Flavonoids as potential anti-inflammatory molecules: a review. Molecules 27(9):2901","journal-title":"Molecules"},{"key":"10579_CR49","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2025.2477077","author":"M Lahouty","year":"2025","unstructured":"Lahouty M, Amirhossein S, Sama K, Haniyeh S-M, Sanaz M, Arash G et al (2025) Cell-based immunotherapy in oesophageal cancer. J Drug Target. https:\/\/doi.org\/10.1080\/1061186X.2025.2477077","journal-title":"J Drug Target"},{"issue":"1","key":"10579_CR50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13058-024-01810-z","volume":"26","author":"S Safaei","year":"2024","unstructured":"Safaei S, Fadaee M, Farzam OR, Yari A, Poursaei E, Aslan C et al (2024) Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies. Breast Cancer Res 26(1):57","journal-title":"Breast Cancer Res"},{"key":"10579_CR51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrc.2023.08.014","volume":"678","author":"Z Taghinejad","year":"2023","unstructured":"Taghinejad Z, Kazemi T, Fadaee M (2023) Pharmacological and therapeutic potentials of cordycepin in hematological malignancies. Biochem Biophys Res Commun 678:135\u2013143","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10579_CR52","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/1061186X.2024.2449482","volume":"33","author":"S Arabi","year":"2025","unstructured":"Arabi S, Manouchehr F, Tohid K, Rahmani M (2025) Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies. J Drug Target 33(5):749\u2013760","journal-title":"J Drug Target"},{"issue":"1","key":"10579_CR53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11033-024-10157-9","volume":"52","author":"M Lahouty","year":"2024","unstructured":"Lahouty M, Fadaee M, Shanehbandi D, Kazemi T (2024) Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment. Mol Biol Rep 52(1):83","journal-title":"Mol Biol Rep"},{"issue":"1","key":"10579_CR54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12964-024-01906-1","volume":"22","author":"S Babaei","year":"2024","unstructured":"Babaei S, Fadaee M, Abbasi-kenarsari H, Shanehbandi D, Kazemi T (2024) Exosome-based immunotherapy as an innovative therapeutic approach in melanoma. Cell Commun Signal 22(1):527","journal-title":"Cell Commun Signal"},{"issue":"1","key":"10579_CR55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12935-024-03544-6","volume":"24","author":"N Orooji","year":"2024","unstructured":"Orooji N, Fadaee M, Kazemi T, Yousefi B (2024) Exosome therapeutics for non-small cell lung cancer tumorigenesis. Cancer Cell Int 24(1):360","journal-title":"Cancer Cell Int"},{"key":"10579_CR56","doi-asserted-by":"crossref","unstructured":"Asgharzadeh M, Najafi-Ghalehlou N, Poor BM, Asgharzadeh V, Pourostadi M, Vegari A, et al (2021) IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran. Endocrine, Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders).21(3):520\u2013525.","DOI":"10.2174\/1871530320666200505123443"},{"key":"10579_CR57","doi-asserted-by":"crossref","first-page":"100651","DOI":"10.1016\/j.genrep.2020.100651","volume":"19","author":"M Asgharzadeh","year":"2020","unstructured":"Asgharzadeh M, Fadaee M, Leylabadlo HE, Mahdavi Poor B, Rashedi J, Asgharzadeh V et al (2020) TNF-\u03b1 gene polymorphism in Iranian Azeri population. Gene Rep 19:100651","journal-title":"Gene Rep"},{"issue":"2","key":"10579_CR58","first-page":"67","volume":"1","author":"A Vaisi-Raygani","year":"2021","unstructured":"Vaisi-Raygani A, Asgari R (2021) Association of inflammation with female reproductive system disorders. Central Asian J Med Pharm Sci Innov 1(2):67\u201373","journal-title":"Central Asian J Med Pharm Sci Innov"},{"issue":"5","key":"10579_CR59","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.3390\/ijms24054666","volume":"24","author":"AJ Ol\u0119dzka","year":"2023","unstructured":"Ol\u0119dzka AJ, Czerwi\u0144ska ME (2023) Role of plant-derived compounds in the molecular pathways related to inflammation. Int J Mol Sci 24(5):4666","journal-title":"Int J Mol Sci"},{"key":"10579_CR60","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.toxrep.2023.04.006","volume":"10","author":"OA Ojo","year":"2023","unstructured":"Ojo OA, Nwafor-Ezeh PI, Rotimi DE, Iyobhebhe M, Ogunlakin AD, Ojo AB (2023) Apoptosis, inflammation, and oxidative stress in infertility: a mini review. Toxicol Rep 10:448\u2013462","journal-title":"Toxicol Rep"},{"issue":"11","key":"10579_CR61","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","volume":"184","author":"PT Saunders","year":"2021","unstructured":"Saunders PT, Horne AW (2021) Endometriosis: etiology, pathobiology, and therapeutic prospects. Cell 184(11):2807\u20132824","journal-title":"Cell"},{"issue":"5","key":"10579_CR62","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/biof.1842","volume":"48","author":"M Fadaee","year":"2022","unstructured":"Fadaee M, Abbasi H, Maralbashi S, Baradaran B, Shanehbandi D, Dinevari MF, Kazemi T (2022) Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs. BioFactors 48(5):1137\u20131144","journal-title":"BioFactors"},{"issue":"1","key":"10579_CR63","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1038\/s41598-024-58064-0","volume":"14","author":"G Pratama","year":"2024","unstructured":"Pratama G, Wiweko B, Asmarinah WIS, Andraini T, Bayuaji H, Hestiantoro A (2024) Mechanism of elevated LH\/FSH ratio in lean PCOS revisited: a path analysis. Sci Rep 14(1):8229","journal-title":"Sci Rep"},{"key":"10579_CR64","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.2147\/NDT.S91700","volume":"12","author":"SL Blay","year":"2016","unstructured":"Blay SL, Aguiar JV, Passos IC (2016) Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis. Neuropsychiatr Dis Treat 12:2895\u20132903","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"1","key":"10579_CR65","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13048-020-0616-z","volume":"13","author":"F Pourteymour Fard Tabrizi","year":"2020","unstructured":"Pourteymour Fard Tabrizi F, Hajizadeh-Sharafabad F, Vaezi M, Jafari-Vayghan H, Alizadeh M, Maleki V (2020) Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review. J Ovar Res 13(1):11","journal-title":"J Ovar Res"},{"issue":"4","key":"10579_CR66","first-page":"214","volume":"24","author":"B McEwen","year":"2018","unstructured":"McEwen B, Hartmann G (2018) Insulin resistance\u2019and polycystic ovary syndrome (PCOS)\u2019: Part 1. The impact of insulin resistance. J Australian Trad Med Soc 24(4):214\u2013219","journal-title":"J Australian Trad Med Soc"},{"issue":"2","key":"10579_CR67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humupd\/dmaa039","volume":"27","author":"GF Meresman","year":"2021","unstructured":"Meresman GF, G\u00f6tte M, Laschke MW (2021) Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies. Hum Reprod Update 27(2):367\u2013392","journal-title":"Hum Reprod Update"},{"issue":"4","key":"10579_CR68","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3390\/nu13041347","volume":"13","author":"A Go\u0142\u0105bek","year":"2021","unstructured":"Go\u0142\u0105bek A, Kowalska K, Olejnik A (2021) Polyphenols as a diet therapy concept for endometriosis\u2014current opinion and future perspectives. Nutrients 13(4):1347","journal-title":"Nutrients"},{"issue":"5","key":"10579_CR69","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/jcm9051309","volume":"9","author":"A Zubrzycka","year":"2020","unstructured":"Zubrzycka A, Zubrzycki M, Perdas E, Zubrzycka M (2020) Genetic, epigenetic, and steroidogenic modulation mechanisms in endometriosis. J Clin Med 9(5):1309","journal-title":"J Clin Med"},{"issue":"15","key":"10579_CR70","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.3390\/ijms20153822","volume":"20","author":"RM Marquardt","year":"2019","unstructured":"Marquardt RM, Kim TH, Shin JH, Jeong JW (2019) Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis? Int J Mol Sci 20(15):3822","journal-title":"Int J Mol Sci"},{"key":"10579_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00935","author":"E Garc\u00eda-G\u00f3mez","year":"2020","unstructured":"Garc\u00eda-G\u00f3mez E, V\u00e1zquez-Mart\u00ednez ER, Reyes-Mayoral C, Cruz-Orozco OP, Camacho-Arroyo I, Cerb\u00f3n M (2020) Regulation of inflammation pathways and inflammasome by sex steroid hormones in endometriosis. Front Endocrinol. https:\/\/doi.org\/10.3389\/fendo.2019.00935","journal-title":"Front Endocrinol"},{"issue":"2","key":"10579_CR72","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1586\/17512433.2016.1129895","volume":"9","author":"N Pluchino","year":"2016","unstructured":"Pluchino N, Freschi L, Wenger JM, Streuli I (2016) Innovations in classical hormonal targets for endometriosis. Expert Rev Clin Pharmacol 9(2):317\u2013327","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"4","key":"10579_CR73","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/cells11040647","volume":"11","author":"JA MacLean","year":"2022","unstructured":"MacLean JA, Hayashi K (2022) Progesterone actions and resistance in gynecological disorders. Cells 11(4):647","journal-title":"Cells"},{"issue":"5","key":"10579_CR74","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/09513590.2022.2047172","volume":"38","author":"S Vannuccini","year":"2022","unstructured":"Vannuccini S, Biagiotti C, Esposto MC, La Torre F, Clemenza S, Orlandi G et al (2022) Long-term treatment of endometriosis-related pain among women seeking hormonal contraception. Gynecol Endocrinol 38(5):398\u2013402","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"10579_CR75","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/endocrines3020028","volume":"3","author":"L Tro\u00eca","year":"2022","unstructured":"Tro\u00eca L, Luisi S (2022) Estro-progestins and pain relief in endometriosis. Endocrines 3(2):349\u2013366","journal-title":"Endocrines"},{"issue":"13","key":"10579_CR76","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.3390\/nu15132967","volume":"15","author":"V Tassinari","year":"2023","unstructured":"Tassinari V, Smeriglio A, Stillittano V, Trombetta D, Zilli R, Tassinari R et al (2023) Endometriosis treatment: role of natural polyphenols as anti-inflammatory agents. Nutrients 15(13):2967","journal-title":"Nutrients"},{"key":"10579_CR77","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejogrb.2016.05.032","volume":"209","author":"C Tosti","year":"2017","unstructured":"Tosti C, Biscione A, Morgante G, Bifulco G, Luisi S, Petraglia F (2017) Hormonal therapy for endometriosis: from molecular research to bedside. Eur J Obstet Gynecol Reprod Biol 209:61\u201366","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10579_CR78","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4183\/aeb.2019.276","volume":"15","author":"AA Gheorghisan-Galateanu","year":"2019","unstructured":"Gheorghisan-Galateanu AA, Gheorghiu ML (2019) Hormonal therapy in women of reproductive age with endometriosis: an update. Acta Endocrinol (Buchar) 15(2):276\u2013281","journal-title":"Acta Endocrinol (Buchar)"},{"key":"10579_CR79","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejogrb.2021.05.002","volume":"262","author":"A Adamietz","year":"2021","unstructured":"Adamietz A, Boosz A, Mueller A, Hornung D, Trunk K, Beckmann MW et al (2021) Complementary and alternative medicine (CAM) in women with endometriosis. Eur J Obstet Gynecol Reprod Biol 262:7\u201312","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10579_CR80","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259375","author":"E Guida","year":"2022","unstructured":"Guida E, Tassinari V, Colopi A, Todaro F, Cesarini V, Jannini B et al (2022) MAPK activation drives male and female mouse teratocarcinomas from late primordial germ cells. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.259375","journal-title":"J Cell Sci"},{"key":"10579_CR81","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/B978-0-444-63602-7.00003-5","volume":"48","author":"M Catarino","year":"2016","unstructured":"Catarino M, Talhi O, Rabahi A, Silva A, Cardoso S (2016) The antiinflammatory potential of flavonoids: mechanistic aspects. Stud Nat Prod Chem 48:65\u201399","journal-title":"Stud Nat Prod Chem"},{"key":"10579_CR82","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.theriogenology.2020.01.019","volume":"150","author":"B Rodr\u00edguez-Alonso","year":"2020","unstructured":"Rodr\u00edguez-Alonso B, S\u00e1nchez JM, Gonz\u00e1lez E, Lonergan P, Rizos D (2020) Challenges in studying preimplantation embryo-maternal interaction in cattle. Theriogenology 150:139\u2013149","journal-title":"Theriogenology"},{"issue":"6","key":"10579_CR83","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.tjog.2020.09.038","volume":"59","author":"A Bolouki","year":"2020","unstructured":"Bolouki A, Zal F, Mostafavi-pour Z, Bakhtari A (2020) Protective effects of quercetin on uterine receptivity markers and blastocyst implantation rate in diabetic pregnant mice. Taiwan J Obstet Gynecol 59(6):927\u2013934","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"5","key":"10579_CR84","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/jog.14219","volume":"46","author":"A Bolouki","year":"2020","unstructured":"Bolouki A, Zal F, Alaee S (2020) Ameliorative effects of quercetin on the preimplantation embryos development in diabetic pregnant mice. J Obstet Gynaecol Res 46(5):736\u2013744","journal-title":"J Obstet Gynaecol Res"},{"issue":"3","key":"10579_CR85","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.fertnstert.2009.07.042","volume":"92","author":"F Taniguchi","year":"2009","unstructured":"Taniguchi F, Tagashira Y, Suou K, Iwabe T, Harada T (2009) Apigenin inhibits TNF\u03b1-induced cell proliferation in endometriotic stromal cells. Fertil Steril 92(3):S11","journal-title":"Fertil Steril"},{"issue":"9","key":"10579_CR86","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/ptr.6677","volume":"34","author":"W Park","year":"2020","unstructured":"Park W, Park MY, Song G, Lim W (2020) 5,7-Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway. Phytother Res 34(9):2275\u20132286","journal-title":"Phytother Res"},{"issue":"1","key":"10579_CR87","first-page":"128","volume":"12","author":"AJ Barinda","year":"2022","unstructured":"Barinda AJ, Arozal W, Sandhiutami NMD, Louisa M, Arfian N, Sandora N, Yusuf M (2022) Curcumin prevents epithelial-to mesenchymal transition-mediated ovarian cancer progression through NRF2\/ETBR\/ET-1 axis and preserves mitochondria biogenesis in kidney after cisplatin administration. Adv Pharm Bull 12(1):128\u2013141","journal-title":"Adv Pharm Bull"},{"issue":"2","key":"10579_CR88","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3892\/etm.2020.8880","volume":"20","author":"Y Qi","year":"2020","unstructured":"Qi Y, Ding Z, Yao Y, Ren F, Yin M, Yang S, Chen A (2020) Apigenin induces apoptosis and counteracts cisplatin-induced chemoresistance via Mcl-1 in ovarian cancer cells. Exp Ther Med 20(2):1329\u20131336","journal-title":"Exp Ther Med"},{"issue":"1","key":"10579_CR89","doi-asserted-by":"crossref","first-page":"2258422","DOI":"10.1080\/09513590.2023.2258422","volume":"39","author":"W Zhou","year":"2023","unstructured":"Zhou W, Chen A, Ye Y, Ren Y, Lu J, Xuan F, Jin R (2023) LIPUS combined with TFSC alleviates premature ovarian failure by promoting autophagy and inhibiting apoptosis. Gynecol Endocrinol 39(1):2258422","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"10579_CR90","doi-asserted-by":"crossref","first-page":"971","DOI":"10.13005\/bpj\/849","volume":"8","author":"KJ Hossein","year":"2015","unstructured":"Hossein KJ, Leila KJ, Koukhdan Ebrahim T, Nazanin SJ, Farzad P, Elham R (2015) The effect of pomegranate juice extract on hormonal changes of female Wistar rats caused by polycystic ovarian syndrome. Biomed Pharmacol J 8(2):971\u2013977","journal-title":"Biomed Pharmacol J"},{"issue":"4","key":"10579_CR91","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.imr.2016.10.002","volume":"5","author":"A Saiyed","year":"2016","unstructured":"Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH (2016) Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res 5(4):293\u2013300","journal-title":"Integr Med Res"},{"issue":"3","key":"10579_CR92","first-page":"173","volume":"17","author":"SI Khodarahmi","year":"2023","unstructured":"Khodarahmi SI, Mortazavi P, Eidi A (2023) Effect of green tea extract (Camellia sinensis) on polycystic ovary syndrome induced by letrozole in adult female Wistar rats. Veter Clin Pathol Quart Sci J 17(3):173\u2013184","journal-title":"Veter Clin Pathol Quart Sci J"},{"key":"10579_CR93","doi-asserted-by":"crossref","first-page":"e202401102","DOI":"10.1002\/cbdv.202401102","volume":"22","author":"N Nasr","year":"2024","unstructured":"Nasr N, Elbatanony M, Hamed MA (2024) GC\/MS analysis and compounds isolation of\u00a0Lycium shawii petroleum ether seeds extract for regulating Nrf2\/OH-1 pathway, oxidative stress and inflammation in acrylamide- induced infertility in female rats. Chem Biodivers 22:e202401102","journal-title":"Chem Biodivers"},{"issue":"7","key":"10579_CR94","doi-asserted-by":"crossref","first-page":"e202400062","DOI":"10.1002\/cbdv.202400062","volume":"21","author":"AF Aboul Naser","year":"2024","unstructured":"Aboul Naser AF, El-Feky AM, Hamed MA (2024) Mitigating effect of lepidium sativum seeds oil on ovarian oxidative stress, DNA abnormality and hormonal disturbances induced by acrylamide in rats. Chem Biodivers 21(7):e202400062","journal-title":"Chem Biodivers"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10579-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10579-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10579-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:28:47Z","timestamp":1766852927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10579-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10579"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10579-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"495"}}