{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:16:23Z","timestamp":1783350983571,"version":"3.54.6"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10603-2","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T05:01:09Z","timestamp":1748062869000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genistein as a renoprotective agent: mechanistic insights into antioxidant, anti-inflammatory, and fibrosis-regulating pathways"],"prefix":"10.1007","volume":"52","author":[{"given":"Ayush","family":"Kattna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-4293","authenticated-orcid":false,"given":"Lovedeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"10603_CR1","unstructured":"Nalley CM (2017) Fluids and electrolytes. The Harriet Lane Handbook E-Book: The Harriet Lane Handbook E-Book. 290"},{"issue":"4","key":"10603_CR2","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","volume":"105","author":"PE Stevens","year":"2024","unstructured":"Stevens PE, Ahmed SB, Carrero JJ, Foster B, Francis A, Hall RK et al (2024) KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105(4):S117\u2013314","journal-title":"Kidney Int"},{"issue":"1","key":"10603_CR3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","volume":"371","author":"LS Chawla","year":"2014","unstructured":"Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) AKI and CKD as interconnected syndromes. N Engl J Med 371(1):58\u201366","journal-title":"N Engl J Med"},{"issue":"4","key":"10603_CR4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","volume":"13","author":"LS Chawla","year":"2017","unstructured":"Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM et al (2017) AKD and renal recovery: consensus report of the acute disease quality initiative (ADQI) 16 workgroup. Nat Rev Nephrol 13(4):241\u2013257","journal-title":"Nat Rev Nephrol"},{"issue":"13","key":"10603_CR5","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.2019.14745","volume":"322","author":"TK Chen","year":"2019","unstructured":"Chen TK, Knicely DH, Grams ME (2019) Chronic kidney disease diagnosis and management: a review. JAMA 322(13):1294\u20131304","journal-title":"JAMA"},{"issue":"1","key":"10603_CR6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","volume":"12","author":"CP Kovesdy","year":"2022","unstructured":"Kovesdy CP (2022) Epidemiology of chronic kidney disease: an update 2022. Kidney Int Supplements 12(1):7\u201311","journal-title":"Kidney Int Supplements"},{"issue":"3","key":"10603_CR7","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1016\/S2214-109X(24)00050-0","volume":"12","author":"M Jadoul","year":"2024","unstructured":"Jadoul M, Aoun M, Imani MM (2024) The major global burden of chronic kidney disease. Lancet Global Health 12(3):e342\u2013e343","journal-title":"Lancet Global Health"},{"issue":"1","key":"10603_CR8","doi-asserted-by":"crossref","first-page":"e14420","DOI":"10.1111\/nep.14420","volume":"30","author":"R Talukdar","year":"2025","unstructured":"Talukdar R, Ajayan R, Gupta S, Biswas S, Parveen M, Sadhukhan D et al (2025) CKD prevalence in India: A systematic review and Meta-Analysis from Community\u2010Based representative evidence between 2011 to 2023. Nephrology 30(1):e14420","journal-title":"Nephrology"},{"issue":"7","key":"10603_CR9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/nu9070718","volume":"9","author":"JM Dennis","year":"2017","unstructured":"Dennis JM, Witting PK (2017) Protective role for antioxidants in acute kidney disease. Nutrients 9(7):718","journal-title":"Nutrients"},{"key":"10603_CR10","doi-asserted-by":"crossref","unstructured":"Gyur\u00e1szov\u00e1 M, Gureck\u00e1 R, B\u00e1b\u00ed\u010dkov\u00e1 J, T\u00f3thov\u00e1 \u013d (2020) Oxidative stress in the pathophysiology of kidney disease: implications for noninvasive monitoring and identification of biomarkers. Oxidative Med Cell Longev. (1):5478708","DOI":"10.1155\/2020\/5478708"},{"key":"10603_CR11","doi-asserted-by":"crossref","unstructured":"Liu N, Xu H, Sun Q, Yu X, Chen W, Wei H et al (2021) The role of oxidative stress in hyperuricemia and Xanthine oxidoreductase (XOR) inhibitors. Oxidative medicine and cellular longevity. (1):1470380","DOI":"10.1155\/2021\/1470380"},{"issue":"12","key":"10603_CR12","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3390\/biology11121717","volume":"11","author":"S Alsawaf","year":"2022","unstructured":"Alsawaf S, Alnuaimi F, Afzal S, Thomas RM, Chelakkot AL, Ramadan WS et al (2022) Plant flavonoids on oxidative stress-mediated kidney inflammation. Biology 11(12):1717","journal-title":"Biology"},{"issue":"1","key":"10603_CR13","doi-asserted-by":"crossref","first-page":"e143703","DOI":"10.5812\/ijpr-143703","volume":"23","author":"B Aouey","year":"2024","unstructured":"Aouey B, Boukholda K, Ciobica A, Burlui V, Soulimani R, Chigr F et al (2024) Renal fibrosis and oxidative stress induced by silica nanoparticles in male rats and its molecular mechanisms. Iran J Pharm Research: IJPR 23(1):e143703","journal-title":"Iran J Pharm Research: IJPR"},{"issue":"4","key":"10603_CR14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.trsl.2014.07.010","volume":"165","author":"SY Lee","year":"2015","unstructured":"Lee SY, Kim SI, Choi ME (2015) Therapeutic targets for treating fibrotic kidney diseases. Translational Res 165(4):512\u2013530","journal-title":"Translational Res"},{"key":"10603_CR15","doi-asserted-by":"crossref","unstructured":"Cassidy H, Radford R, Slyne J, O\u2019Connell S, Slattery C, Ryan MP et al (2012) The role of MAPK in drug-induced kidney injury. J Signal Transduct. (1):463617","DOI":"10.1155\/2012\/463617"},{"issue":"4","key":"10603_CR16","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/ndt\/gfr550","volume":"27","author":"N Sugiyama","year":"2012","unstructured":"Sugiyama N, Kohno M, Yokoyama T (2012) Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model. Nephrol Dialysis Transplantation 27(4):1351\u20131358","journal-title":"Nephrol Dialysis Transplantation"},{"issue":"1","key":"10603_CR17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12325-021-01927-z","volume":"39","author":"M Evans","year":"2022","unstructured":"Evans M, Lewis RD, Morgan AR, Whyte MB, Hanif W, Bain SC et al (2022) A narrative review of CKDin clinical practice: current challenges and future perspectives. Adv Therapy 39(1):33\u201343","journal-title":"Adv Therapy"},{"issue":"7","key":"10603_CR18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","volume":"20","author":"A Francis","year":"2024","unstructured":"Francis A, Harhay MN, Ong AC, Tummalapalli SL, Ortiz A, Fogo AB (2024) CKDand the global public health agenda: an international consensus. Nat Rev Nephrol 20(7):473\u2013485","journal-title":"Nat Rev Nephrol"},{"key":"10603_CR19","first-page":"2515690X2210796","volume":"27","author":"MA Khan","year":"2022","unstructured":"Khan MA, Kassianos AJ, Hoy WE, Alam AK, Healy HG, Gobe GC (2022) Promoting plant-based therapies for chronic kidney disease. J Evidence-Based Integr Med 27:2515690X221079688","journal-title":"J Evidence-Based Integr Med"},{"issue":"20","key":"10603_CR20","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.3390\/molecules26206096","volume":"26","author":"L Avila-Carrasco","year":"2021","unstructured":"Avila-Carrasco L, Garc\u00eda-Mayorga EA, D\u00edaz-Avila DL, Garza-Veloz I, Martinez-Fierro ML, Gonz\u00e1lez-Mateo GT (2021) Potential therapeutic effects of natural plant compounds in kidney disease. Molecules 26(20):6096","journal-title":"Molecules"},{"issue":"1","key":"10603_CR21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.clnu.2015.03.012","volume":"35","author":"Z Jing","year":"2016","unstructured":"Jing Z, Wei-Jie Y (2016) Effects of soy protein containing isoflavones in patients with chronic kidney disease: A systematic review and meta-analysis. Clin Nutr 35(1):117\u2013124","journal-title":"Clin Nutr"},{"issue":"10","key":"10603_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mnfr.202000015","volume":"64","author":"HF Jheng","year":"2020","unstructured":"Jheng HF, Hayashi K, Matsumura Y, Kawada T, Seno S, Matsuda H et al (2020) Anti-Inflammatory and antioxidative properties of isoflavones provide renal protective effects distinct from those of dietary soy proteins against diabetic nephropathy. Mol Nutr Food Res 64(10):1\u201336","journal-title":"Mol Nutr Food Res"},{"key":"10603_CR23","doi-asserted-by":"crossref","unstructured":"G\u0103man AM, Egbuna C, G\u0103man MA (2020) Natural bioactive lead compounds effective against haematological malignancies. Phytochemicals as lead compounds for new drug discovery. 95\u2013115","DOI":"10.1016\/B978-0-12-817890-4.00006-8"},{"key":"10603_CR24","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad J, Quispe C, Imran M, Rauf A, Nadeem M, Gondal TA et al (2021) Genistein: an integrative overview of its mode of action, Pharmacological properties, and health benefits. Oxidative Med Cell Longev. (1):3268136","DOI":"10.1155\/2021\/3268136"},{"issue":"7","key":"10603_CR25","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2174\/0113892010265344230919170611","volume":"25","author":"K Bansal","year":"2024","unstructured":"Bansal K, Singh V, Mishra S, Bajpai M (2024) Articulating the Pharmacological and Nanotechnological aspects of Genistein: current and future prospectives. Curr Pharm Biotechnol 25(7):807\u2013824","journal-title":"Curr Pharm Biotechnol"},{"key":"10603_CR26","doi-asserted-by":"publisher","unstructured":"Gholampour F, Mohammadi Z, Karimi Z, Owji SM (2020) Gene protective effect of genistein in a rat model of ischemic acute kidney injury. 753:144789. https:\/\/doi.org\/10.1016\/j.gene.2020.144789","DOI":"10.1016\/j.gene.2020.144789"},{"issue":"1\u20133","key":"10603_CR27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ejphar.2011.06.011","volume":"667","author":"N Palanisamy","year":"2011","unstructured":"Palanisamy N, Kannappan S, Anuradha CV (2011) Genistein modulates NF-\u039aB-Associated renal inflammation, fibrosis and podocyte abnormalities in Fructose-Fed rats. Eur J Pharmacol 667(1\u20133):355\u2013364","journal-title":"Eur J Pharmacol"},{"key":"10603_CR28","doi-asserted-by":"crossref","unstructured":"Sung M, Jeong DH, Kim YJ, Jung KP, Kang AS, Lee et al (2008) Genistein protects the kidney from Cisplatin-Induced injury. Kidney Int 74(12):1538\u20131547","DOI":"10.1038\/ki.2008.409"},{"issue":"6","key":"10603_CR29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.nut.2008.11.027","volume":"25","author":"JS Choi","year":"2009","unstructured":"Choi JS, Song J (2009) Effect of genistein on insulin resistance, renal lipid metabolism, and antioxidative activities in ovariectomized rats. Nutrition 25(6):676\u2013685. https:\/\/doi.org\/10.1016\/j.nut.2008.11.027","journal-title":"Nutrition"},{"issue":"6","key":"10603_CR30","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/j.1523-1755.2004.66008.x","volume":"66","author":"SL Zhang","year":"2004","unstructured":"Zhang SL, Guo J, Moini B, Ingelfinger JR (2004) Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. Kidney Int 66(6):2181\u20132192","journal-title":"Kidney Int"},{"issue":"2","key":"10603_CR31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4314\/tjpr.v16i2.13","volume":"16","author":"SL Wang","year":"2017","unstructured":"Wang SL, Duan L, Li W, Wang GM, Zhang MY (2017) Genistein attenuates ischemia\/reperfusion injury in rat kidneys via enhancement of antioxidant defense mechanisms: activation of Nrf-2\/HO-1 signaling. Trop J Pharm Res 16(2):349\u2013356","journal-title":"Trop J Pharm Res"},{"issue":"1","key":"10603_CR32","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/09540105.2021.1996540","volume":"32","author":"B Wei-Yun","year":"2021","unstructured":"Wei-Yun B, Cailin Z (2021) Genistein ameliorates Hyperuricemia-Associated nephropathy in hyperuricemic mice. Food Agricultural Immunol 32(1):778\u2013797","journal-title":"Food Agricultural Immunol"},{"issue":"6","key":"10603_CR33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/08860220802134532","volume":"30","author":"N Palanisamy","year":"2008","unstructured":"Palanisamy N, Viswanathan P, Anuradha CV (2008) Effect of Genistein, a soy Isof Lavone, on whole body insulin sensitivity and renal damage induced by a High-Fructose diet. Ren Fail 30(6):645\u2013654","journal-title":"Ren Fail"},{"issue":"1","key":"10603_CR34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3892\/br.2015.547","volume":"4","author":"E Canyilmaz","year":"2016","unstructured":"Canyilmaz E, Uslu GH, Bahat Z, Kandaz M, Mungan S, Haciislamoglu E et al (2016) Comparison of the effects of melatonin and genistein on Radiation\u2013induced nephrotoxicity: results of an experimental study. Biomedical Rep 4(1):45\u201350","journal-title":"Biomedical Rep"},{"key":"10603_CR35","doi-asserted-by":"crossref","unstructured":"Jalili C, Rashidi I, Roshankhah S, Jalili F, Salahshoor MR (2020) Protective effect of genistein on the Morphine-Induced kidney disorders in male mice. Electron J Gen Med 17(3)","DOI":"10.29333\/ejgm\/7874"},{"key":"10603_CR36","doi-asserted-by":"crossref","unstructured":"Li WF, Yang K, Zhu P, Zhao HQ, Song YH, Liu KC et al (2017) Genistein ameliorates Ischemia\/Reperfusion-Induced renal injury in a SIRT1-Dependent manner. Nutrients 9(4)","DOI":"10.3390\/nu9040403"},{"key":"10603_CR37","doi-asserted-by":"crossref","unstructured":"Kim MJ, Lim Y (2013) Protective effect of Short-Term genistein supplementation on the early stage in Diabetes-Induced renal damage. Mediat Inflamm. (1):510212","DOI":"10.1155\/2013\/510212"},{"issue":"4","key":"10603_CR38","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.kint.2015.12.045","volume":"89","author":"LR Rega","year":"2016","unstructured":"Rega LR, Polishchuk E, Montefusco S, Napolitano G, Tozzi G, Zhang J et al (2016) Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells. Kidney Int 89(4):862\u2013873","journal-title":"Kidney Int"},{"issue":"6","key":"10603_CR39","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10522-011-9345-4","volume":"12","author":"JM Kim","year":"2011","unstructured":"Kim JM, Uehara Y, Choi YJ, Ha YM, Ye BH, Yu BP et al (2011) Mechanism of Attenuation of Pro-Inflammatory Ang II-Induced NF-\u039aB activation by genistein in the kidneys of male rats during aging. Biogerontology 12(6):537\u2013550","journal-title":"Biogerontology"},{"issue":"5\u20136","key":"10603_CR40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.vph.2011.07.007","volume":"55","author":"AA Elmarakby","year":"2011","unstructured":"Elmarakby AA, Ibrahim AS, Faulkner J, Mozaffari MS, Liou GI, Abdelsayed R (2011) Tyrosine kinase inhibitor, Genistein, reduces renal inflammation and injury in Streptozotocin-Induced diabetic mice. Vascul Pharmacol 55(5\u20136):149\u2013156","journal-title":"Vascul Pharmacol"},{"issue":"10","key":"10603_CR41","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1017\/S0007114512003819","volume":"109","author":"N Palanisamy","year":"2013","unstructured":"Palanisamy N, Venkataraman AC (2013) Beneficial effect of genistein on Lowering blood pressure and kidney toxicity in Fructose-Fed hypertensive rats. Br J Nutr 109(10):1806\u20131812","journal-title":"Br J Nutr"},{"key":"10603_CR42","first-page":"096032712311649","volume":"42","author":"HY He","year":"2023","unstructured":"He HY, Shan HZ, Li SQ, Diao RG (2023) Genistein attenuates renal ischemia-reperfusion injury via ADORA2A pathway. Hum Exp Toxicol 42:09603271231164913","journal-title":"Hum Exp Toxicol"},{"key":"10603_CR43","doi-asserted-by":"crossref","unstructured":"Lian Y, Tian Z, Cao H, Jia Z, Yan T, Li D (2021) Genistein Mitigates High Glucose-Induced Podocyte Adhesion Injury by Modulating Autophagy via Mtor Signal","DOI":"10.21203\/rs.3.rs-1078189\/v1"},{"key":"10603_CR44","doi-asserted-by":"crossref","unstructured":"Yan Z, Shao T (2024) Chronic inflammation in chronic kidney disease. Nephron. 148(3):143\u2013\u200951","DOI":"10.1159\/000534447"},{"issue":"2","key":"10603_CR45","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3390\/ijms24021415","volume":"24","author":"PG Vall\u00e9s","year":"2023","unstructured":"Vall\u00e9s PG, Gil Lorenzo AF, Garcia RD, Cacciamani V, Benardon ME, Costantino VV (2023) Toll-like receptor 4 in acute kidney injury. Int J Mol Sci 24(2):1415","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10603_CR46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/acel.12322","volume":"14","author":"S Gargiulo","year":"2015","unstructured":"Gargiulo S, Gamba P, Testa G, Rossin D, Biasi F, Poli G et al (2015) Relation between TLR4\/NF-\u03baB signaling pathway activation by 27\u2010hydroxycholesterol and 4\u2010hydroxynonenal, and atherosclerotic plaque instability. Aging Cell 14(4):569\u2013581","journal-title":"Aging Cell"},{"issue":"1","key":"10603_CR47","first-page":"1","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun SC (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Therapy 2(1):1\u20139","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"10603_CR48","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1038\/s41467-021-25728-8","volume":"12","author":"J Br\u00e4gelmann","year":"2021","unstructured":"Br\u00e4gelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L et al (2021) MAPK-pathway Inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun 12(1):5505","journal-title":"Nat Commun"},{"issue":"2","key":"10603_CR49","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1074\/jbc.270.2.933","volume":"270","author":"HC Ledebur","year":"1995","unstructured":"Ledebur HC, Parks TP (1995) Transcriptional regulation of the intercellular adhesion Molecule-1 gene by inflammatory cytokines in human endothelial cells: ESSENTIAL ROLES OF A VARIANT NF-\u03baB SITE AND p65 HOMODIMERS (\u2217). J Biol Chem 270(2):933\u2013943","journal-title":"J Biol Chem"},{"issue":"10","key":"10603_CR50","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1136\/jcp.45.10.880","volume":"45","author":"J Chow","year":"1992","unstructured":"Chow J, Hartley RB, Jagger C, Dilly SA (1992) ICAM-1 expression in renal disease. J Clin Pathol 45(10):880\u2013884","journal-title":"J Clin Pathol"},{"issue":"3","key":"10603_CR51","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","volume":"108","author":"TM Bui","year":"2020","unstructured":"Bui TM, Wiesolek HL, Sumagin R (2020) A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leucocyte Biology 108(3):787\u2013799","journal-title":"J Leucocyte Biology"},{"key":"10603_CR52","doi-asserted-by":"crossref","unstructured":"Lim AK, Tesch GH (2012) Inflammation in diabetic nephropathy. Mediat Inflamm. (1):146154","DOI":"10.1155\/2012\/146154"},{"issue":"4","key":"10603_CR53","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1046\/j.1523-1755.2001.00941.x","volume":"60","author":"SA Mezzano","year":"2001","unstructured":"Mezzano SA, Barr\u00eda M, Droguett MA, Burgos ME, Ardiles LG, Flores C et al (2001) Tubular NF-\u03baB and AP-1 activation in human proteinuric renal disease. Kidney Int 60(4):1366\u20131377","journal-title":"Kidney Int"},{"issue":"10","key":"10603_CR54","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1017\/S0031182014000614","volume":"141","author":"R Zhou","year":"2014","unstructured":"Zhou R, Feng Y, Chen XM (2014) Non-coding RNAs in epithelial immunity to Cryptosporidium infection. Parasitology 141(10):1233\u20131243","journal-title":"Parasitology"},{"issue":"2","key":"10603_CR55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/carcin\/bgh009","volume":"25","author":"DE Frigo","year":"2004","unstructured":"Frigo DE, Tang Y, Beckman BS, Scandurro AB, Alam J, Burow ME et al (2004) Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis 25(2):249\u2013261","journal-title":"Carcinogenesis"},{"key":"10603_CR56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","volume":"213","author":"J Maiuolo","year":"2016","unstructured":"Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V (2016) Regulation of uric acid metabolism and excretion. Int J Cardiol 213:8\u201314","journal-title":"Int J Cardiol"},{"key":"10603_CR57","doi-asserted-by":"crossref","first-page":"667753","DOI":"10.3389\/fphar.2021.667753","volume":"12","author":"HL Sun","year":"2021","unstructured":"Sun HL, Wu YW, Bian HG, Yang H, Wang H, Meng XM et al (2021) Function of uric acid transporters and their inhibitors in hyperuricaemia. Front Pharmacol 12:667753","journal-title":"Front Pharmacol"},{"issue":"2","key":"10603_CR58","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/gucdd2020016","volume":"2","author":"T Takada","year":"2024","unstructured":"Takada T, Miyata H, Toyoda Y, Nakayama A, Ichida K, Matsuo H (2024) Regulation of urate homeostasis by membrane transporters. Gout Urate Cryst Deposition Disease 2(2):206\u2013219","journal-title":"Gout Urate Cryst Deposition Disease"},{"key":"10603_CR59","doi-asserted-by":"crossref","unstructured":"Zhou Y, Fang L, Jiang L, Wen P, Cao H, He W et al (2012) Uric acid induces renal inflammation via activating tubular NF-\u03baB signaling pathway. PLoS ONE. (6): e39738","DOI":"10.1371\/journal.pone.0039738"},{"issue":"6","key":"10603_CR60","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/17425255.2021.1915284","volume":"17","author":"H Koepsell","year":"2021","unstructured":"Koepsell H (2021) Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing. Expert Opin Drug Metab Toxicol 17(6):635\u2013653","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10603_CR61","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.fct.2018.06.040","volume":"118","author":"K Natarajan","year":"2018","unstructured":"Natarajan K, Abraham P, Kota R, Isaac B (2018) NF-\u03baB-iNOS-COX2-TNF \u03b1 inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats. Food Chem Toxicol 118:766\u2013783","journal-title":"Food Chem Toxicol"},{"key":"10603_CR62","doi-asserted-by":"crossref","unstructured":"Javani G, Alihemmati A, Habibi P, Yousefi H, Karimi P, Ebraheimi V et al (2019) The effects of genistein on renal oxidative stress and inflammation of ovariectomized rats. Jundishapur J Nat Pharm Prod 14(4)","DOI":"10.5812\/jjnpp.57149"},{"issue":"9","key":"10603_CR63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1369\/0022155419849388","volume":"67","author":"RD B\u00fclow","year":"2019","unstructured":"B\u00fclow RD, Boor P (2019) Extracellular matrix in kidney fibrosis: more than just a scaffold. J Histochem Cytochemistry 67(9):643\u2013661","journal-title":"J Histochem Cytochemistry"},{"key":"10603_CR64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2017.12.016","volume":"820","author":"W Lv","year":"2018","unstructured":"Lv W, Booz GW, Wang Y, Fan F, Roman RJ (2018) Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets. Eur J Pharmacol 820:65\u201376","journal-title":"Eur J Pharmacol"},{"key":"10603_CR65","doi-asserted-by":"crossref","unstructured":"Meng XM (2019) Inflammatory mediators and renal fibrosis. Renal Fibrosis: Mechanisms and Therapies. 381\u2013406","DOI":"10.1007\/978-981-13-8871-2_18"},{"issue":"9","key":"10603_CR66","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","volume":"10","author":"XM Meng","year":"2014","unstructured":"Meng XM, Nikolic-Paterson DJ, Lan HY (2014) Inflammatory processes in renal fibrosis. Nat Rev Nephrol 10(9):493\u2013503","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"10603_CR67","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3390\/biomedicines9121747","volume":"9","author":"L Lis-L\u00f3pez","year":"2021","unstructured":"Lis-L\u00f3pez L, Bauset C, Seco-Cervera M, Cos\u00edn-Roger J (2021) Is the macrophage phenotype determinant for fibrosis development? Biomedicines 9(12):1747","journal-title":"Biomedicines"},{"issue":"2","key":"10603_CR68","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7150\/ijbs.39024","volume":"16","author":"Y Bai","year":"2020","unstructured":"Bai Y, Wang W, Yin P, Gao J, Na L, Sun Y et al (2020) Ruxolitinib alleviates renal interstitial fibrosis in UUO mice. Int J Biol Sci 16(2):194","journal-title":"Int J Biol Sci"},{"issue":"4","key":"10603_CR69","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4161\/jkst.22729","volume":"1","author":"R Satou","year":"2012","unstructured":"Satou R, Gonzalez-Villalobos RA (2012) JAK-STAT and the renin-angiotensin system: the role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation. Jak-Stat 1(4):250\u2013256","journal-title":"Jak-Stat"},{"issue":"13","key":"10603_CR70","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jacc.2018.01.058","volume":"71","author":"FH Messerli","year":"2018","unstructured":"Messerli FH, Bangalore S, Bavishi C, Rimoldi SF (2018) Angiotensin-converting enzyme inhibitors in hypertension: to use or not to use? J Am Coll Cardiol 71(13):1474\u20131482","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10603_CR71","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/01.CIR.0000139857.85424.45","volume":"110","author":"G Nickenig","year":"2004","unstructured":"Nickenig G (2004) Should angiotensin II receptor blockers and Statins be combined? Circulation 110(8):1013\u20131020","journal-title":"Circulation"},{"issue":"7","key":"10603_CR72","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41440-020-0428-y","volume":"43","author":"R Targo\u0144ski","year":"2020","unstructured":"Targo\u0144ski R, Sadowski J, Price S, Targo\u0144ski R (2020) Sodium-induced inflammation\u2014an invisible player in resistant hypertension. Hypertens Res 43(7):629\u2013633","journal-title":"Hypertens Res"},{"key":"10603_CR73","doi-asserted-by":"crossref","first-page":"1233259","DOI":"10.3389\/fcell.2023.1233259","volume":"11","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang W, Zhang J, Gao S, Xu T, Yin Y (2023) JAK\/STAT signaling in diabetic kidney disease. Front Cell Dev Biology 11:1233259","journal-title":"Front Cell Dev Biology"},{"key":"10603_CR74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13069-015-0023-z","volume":"8","author":"AM Murphy","year":"2015","unstructured":"Murphy AM, Wong AL, Bezuhly M (2015) Modulation of angiotensin II signaling in the prevention of fibrosis. Fibrogenesis Tissue Repair 8:1\u20137","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10603_CR75","doi-asserted-by":"crossref","first-page":"175780","DOI":"10.1016\/j.ejphar.2023.175780","volume":"951","author":"W Parichatikanond","year":"2023","unstructured":"Parichatikanond W, Duangrat R, Mangmool S (2023) G\u03b1q protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-\u03b21\/ERK axis in human cardiac fibroblasts. Eur J Pharmacol 951:175780","journal-title":"Eur J Pharmacol"},{"key":"10603_CR76","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fcell.2020.00123","volume":"8","author":"YY Gu","year":"2020","unstructured":"Gu YY, Liu XS, Huang XR, Yu XQ, Lan HY (2020) Diverse role of TGF-\u03b2 in kidney disease. Front Cell Dev Biology 8:123","journal-title":"Front Cell Dev Biology"},{"issue":"6","key":"10603_CR77","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","volume":"12","author":"XM Meng","year":"2016","unstructured":"Meng XM, Nikolic-Paterson DJ, Lan HY (2016) TGF-\u03b2: the master regulator of fibrosis. Nat Rev Nephrol 12(6):325\u2013338","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10603_CR78","doi-asserted-by":"crossref","first-page":"1331099","DOI":"10.1080\/20022727.2017.1331099","volume":"8","author":"H Miyazawa","year":"2017","unstructured":"Miyazawa H, Hirai K, Ookawara S, Ishibashi K, Morishita Y (2017) Nano-sized carriers in gene therapy for renal fibrosis in vivo. Nano Reviews Experiments 8(1):1331099","journal-title":"Nano Reviews Experiments"},{"issue":"14","key":"10603_CR79","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.7150\/ijbs.62929","volume":"17","author":"YK You","year":"2021","unstructured":"You YK, Wu WF, Huang XR, Li HD, Ren YP, Zeng JC (2021) Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy. Int J Biol Sci 17(14):3911","journal-title":"Int J Biol Sci"},{"key":"10603_CR80","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fphar.2020.00265","volume":"11","author":"D Dorotea","year":"2020","unstructured":"Dorotea D, Koya D, Ha H (2020) Recent insights into SREBP as a direct mediator of kidney fibrosis via lipid-independent pathways. Front Pharmacol 11:265","journal-title":"Front Pharmacol"},{"issue":"6","key":"10603_CR81","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","volume":"15","author":"KM Holmstr\u00f6m","year":"2014","unstructured":"Holmstr\u00f6m KM, Finkel T (2014) Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 15(6):411\u2013421","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10603_CR82","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/cells9061342","volume":"9","author":"MV Irazabal","year":"2020","unstructured":"Irazabal MV, Torres VE (2020) ROS and redox signaling in chronic kidney disease. Cells 9(6):1342","journal-title":"Cells"},{"key":"10603_CR83","volume-title":"Biomarkers in kidney disease","author":"I Fonseca","year":"2016","unstructured":"Fonseca I (2016) Malondialdehyde as a biomarker in kidney transplantation. Biomarkers in kidney disease. Springer Netherlands, Dordrecht. 849\u2013\u200973."},{"key":"10603_CR84","doi-asserted-by":"crossref","unstructured":"Ma X, Wang F, Zhen X, Zhao L, Fang L, Dong Z et al (2020) gp91phox, a novel biomarker evaluating oxidative stress, is elevated in subclinical hypothyroidism. Int J Endocrinol. (1):3161730","DOI":"10.1155\/2020\/3161730"},{"issue":"13","key":"10603_CR85","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3390\/ijms21134777","volume":"21","author":"F He","year":"2020","unstructured":"He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10603_CR86","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ki.2013.248","volume":"84","author":"LM Shelton","year":"2013","unstructured":"Shelton LM, Park BK, Copple IM (2013) Role of Nrf2 in protection against acute kidney injury. Kidney Int 84(6):1090\u20131095","journal-title":"Kidney Int"},{"issue":"8","key":"10603_CR87","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3390\/ijms21082951","volume":"21","author":"M Nezu","year":"2020","unstructured":"Nezu M, Suzuki N (2020) Roles of Nrf2 in protecting the kidney from oxidative damage. Int J Mol Sci 21(8):2951","journal-title":"Int J Mol Sci"},{"key":"10603_CR88","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3892\/mmr.2013.1391","volume":"7","author":"J Guo","year":"2013","unstructured":"Guo J, Wu W, Sheng M, Yang S, Tan J (2013) Amygdalin inhibits renal fibrosis in chronic kidney disease. Mol Med Rep 7:1453\u20131457","journal-title":"Mol Med Rep"},{"key":"10603_CR89","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/MNH.0000000000000556","volume":"29","author":"M Ito","year":"2020","unstructured":"Ito M, Tanaka T, Nangaku M (2020) Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases. Curr Opin Nephrol Hypertens 29:128\u2013135","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10603_CR90","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2015.06.006","volume":"88","author":"T Suzuki","year":"2015","unstructured":"Suzuki T, Yamamoto M (2015) Molecular basis of the Keap1\u2013Nrf2 system. Free Radic Biol Med 88:93\u2013100","journal-title":"Free Radic Biol Med"},{"issue":"15","key":"10603_CR91","doi-asserted-by":"crossref","first-page":"12378","DOI":"10.3390\/ijms241512378","volume":"24","author":"M Darenskaya","year":"2023","unstructured":"Darenskaya M, Kolesnikov S, Semenova N, Kolesnikova L (2023) Diabetic nephropathy: significance of determining oxidative stress and opportunities for antioxidant therapies. Int J Mol Sci 24(15):12378","journal-title":"Int J Mol Sci"},{"key":"10603_CR92","doi-asserted-by":"crossref","unstructured":"Colombijn JM, Hooft L, Jun M, Webster AC, Bots ML, Verhaar MC (2023) Antioxidants for adults with chronic kidney disease. Cochrane Database of Systematic Reviews. (11)","DOI":"10.1002\/14651858.CD008176.pub3"},{"key":"10603_CR93","doi-asserted-by":"crossref","unstructured":"Jorge RJ, Marinho AD, de Moraes Silveira JA, Ramos MM, Braga JR, de Sousa Alves R et al (2022) Antioxidants and kidney diseases. Antioxidants effects in health. Elsevier, pp 755\u2013798","DOI":"10.1016\/B978-0-12-819096-8.00059-8"},{"issue":"7","key":"10603_CR94","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1007\/s11011-022-00956-z","volume":"37","author":"S Patel","year":"2022","unstructured":"Patel S, Khan H, Majumdar A (2022) Crosstalk between sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy. Metab Brain Dis 37(7):2181\u20132195","journal-title":"Metab Brain Dis"},{"key":"10603_CR95","doi-asserted-by":"crossref","first-page":"111552","DOI":"10.1016\/j.biopha.2021.111552","volume":"139","author":"P Liu","year":"2021","unstructured":"Liu P, Li J, Liu M, Zhang M, Xue Y, Zhang Y (2021) Hesperetin modulates the Sirt1\/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. Biomed Pharmacother 139:111552","journal-title":"Biomed Pharmacother"},{"key":"10603_CR96","doi-asserted-by":"crossref","unstructured":"Baylis C (2008) Nitric oxide deficiency in chronic kidney disease. American Journal of Physiology-Renal Physiology","DOI":"10.1152\/ajprenal.00424.2007"},{"issue":"1","key":"10603_CR97","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.bjp.0705407","volume":"140","author":"SM Wileman","year":"2003","unstructured":"Wileman SM, Mann GE, Pearson JD, Baydoun AR (2003) Role of L-citrulline transport in nitric oxide synthesis in rat aortic smooth muscle cells activated with LPS and interferon\u2010\u03b3. Br J Pharmacol 140(1):179\u2013185","journal-title":"Br J Pharmacol"},{"key":"10603_CR98","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4330\/wjc.v2.i6.150","volume":"2","author":"JC Chang","year":"2010","unstructured":"Chang JC, Kou SJ, Lin WT, Liu CS (2010) Regulatory role of mitochondria in oxidative stress and atherosclerosis. World J Cardiol 2:150\u2013159","journal-title":"World J Cardiol"},{"issue":"3","key":"10603_CR99","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1046\/j.1523-1755.2002.00220.x","volume":"61","author":"RC Blantz","year":"2002","unstructured":"Blantz RC, Deng A, Lortie M, Munger K, Vallon V, Gabbai FB (2002) The complex role of nitric oxide in the regulation of glomerular ultrafiltration. Kidney Int 61(3):782\u2013785","journal-title":"Kidney Int"},{"issue":"9","key":"10603_CR100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41581-021-00429-z","volume":"17","author":"M Carlstr\u00f6m","year":"2021","unstructured":"Carlstr\u00f6m M (2021) Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol 17(9):575\u2013590","journal-title":"Nat Rev Nephrol"},{"issue":"11","key":"10603_CR101","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1210\/en.2007-0245","volume":"148","author":"TM Cho","year":"2007","unstructured":"Cho TM, Peng N, Clark JT, Novak L, Roysommuti S, Prasain J et al (2007) Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male rats. Endocrinology 148(11):5396\u20135402","journal-title":"Endocrinology"},{"issue":"1","key":"10603_CR102","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ki.2011.120","volume":"80","author":"A Havasi","year":"2011","unstructured":"Havasi A, Borkan SC (2011) Apoptosis and acute kidney injury. Kidney Int 80(1):29\u201340","journal-title":"Kidney Int"},{"issue":"10","key":"10603_CR103","doi-asserted-by":"crossref","first-page":"mjac074","DOI":"10.1093\/jmcb\/mjac074","volume":"14","author":"Q Hao","year":"2022","unstructured":"Hao Q, Chen J, Lu H, Zhou X (2022) The ARTS of p53-dependent mitochondrial apoptosis. J Mol Cell Biol 14(10):mjac074","journal-title":"J Mol Cell Biol"},{"issue":"2","key":"10603_CR104","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/life12020256","volume":"12","author":"R Roufayel","year":"2022","unstructured":"Roufayel R, Younes K, Al-Sabi A, Murshid N (2022) BH3-only proteins Noxa and Puma are key regulators of induced apoptosis. Life 12(2):256","journal-title":"Life"},{"issue":"2","key":"10603_CR105","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1080\/21655979.2021.2024389","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu Y, Li H, Zhao Y, Li D, Zhang Q, Fu J, Fan S (2022) Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances Imatinib sensitivity in chronic myeloid leukemia. Bioengineered 13(2):2296\u20132307","journal-title":"Bioengineered"},{"issue":"1","key":"10603_CR106","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41420-022-01268-y","volume":"8","author":"Y Gao","year":"2022","unstructured":"Gao Y, Wang N, Jia D (2022) H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury. Cell Death Discovery 8(1):475","journal-title":"Cell Death Discovery"},{"issue":"22","key":"10603_CR107","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/cells13221838","volume":"13","author":"M Mustafa","year":"2024","unstructured":"Mustafa M, Ahmad R, Tantry IQ, Ahmad W, Siddiqui S, Alam M et al (2024) Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications. Cells 13(22):1838","journal-title":"Cells"},{"key":"10603_CR108","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.arr.2018.02.004","volume":"43","author":"AL Ong","year":"2018","unstructured":"Ong AL, Ramasamy TS (2018) Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing Res Rev 43:64\u201380","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10603_CR109","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/cells8010061","volume":"8","author":"TA Lin","year":"2019","unstructured":"Lin TA, Wu VC, Wang CY (2019) Autophagy in chronic kidney diseases. Cells 8(1):61","journal-title":"Cells"},{"issue":"15","key":"10603_CR110","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/cells11152262","volume":"11","author":"L G\u00f3mez-Virgilio","year":"2022","unstructured":"G\u00f3mez-Virgilio L, MdC SL, Flores-Morelos DS, Gallardo-Nieto J, Lopez-Toledo G, Abarca-Fernandez AM (2022) Autophagy: A key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators. Cells 11(15):2262","journal-title":"Cells"},{"issue":"1","key":"10603_CR111","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1038\/s41598-019-46657-z","volume":"9","author":"G Runwal","year":"2019","unstructured":"Runwal G, Stamatakou E, Siddiqi FH, Puri C, Zhu Y, Rubinsztein DC (2019) LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep 9(1):10147","journal-title":"Sci Rep"},{"key":"10603_CR112","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","volume":"75","author":"P Jiang","year":"2015","unstructured":"Jiang P, Mizushima N (2015) LC3-and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods 75:13\u201318","journal-title":"Methods"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10603-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10603-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10603-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:29:44Z","timestamp":1766852984000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10603-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,24]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10603"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10603-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,24]]},"assertion":[{"value":"22 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"500"}}