{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:32:53Z","timestamp":1766853173199,"version":"3.48.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"crossref","award":["19547"],"award-info":[{"award-number":["19547"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10684-z","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:05:00Z","timestamp":1749629100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental autoimmune encephalomyelitis impairs the immunomodulatory effects of mesenchymal stem cells on splenocyte responses"],"prefix":"10.1007","volume":"52","author":[{"given":"Alireza","family":"Yeganeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzam","family":"Ajamian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheida","family":"Farrokhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Fathollahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mahmoud","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-1840","authenticated-orcid":false,"given":"Farshid","family":"Yeganeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"1","key":"10684_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1667-1","volume":"17","author":"N Celarain","year":"2020","unstructured":"Celarain N, Tomas-Roig J (2020) Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients. J Neuroinflamm 17(1):1\u201317","journal-title":"J Neuroinflamm"},{"issue":"12","key":"10684_CR2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/1744666X.2021.1847642","volume":"16","author":"K Ruprecht","year":"2020","unstructured":"Ruprecht K (2020) The role of Epstein-Barr virus in the etiology of multiple sclerosis: a current review. Expert Rev Clin Immunol 16(12):1143\u20131157","journal-title":"Expert Rev Clin Immunol"},{"issue":"1\u20132","key":"10684_CR3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.imlet.2013.06.002","volume":"154","author":"I Kassis","year":"2013","unstructured":"Kassis I et al (2013) Mesenchymal stem cells (MSC) derived from mice with experimental autoimmune encephalomyelitis (EAE) suppress EAE and have similar biological properties with MSC from healthy donors. Immunol Lett 154(1\u20132):70\u201376","journal-title":"Immunol Lett"},{"key":"10684_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00011-018-1185-0","volume":"68","author":"M Gholamzad","year":"2019","unstructured":"Gholamzad M et al (2019) A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future. Inflamm Res 68:25\u201338","journal-title":"Inflamm Res"},{"key":"10684_CR5","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1007\/s12035-020-01998-z","volume":"57","author":"Y Liu","year":"2020","unstructured":"Liu Y et al (2020) Mesenchymal stem cells attenuated blood-brain barrier disruption via downregulation of aquaporin-4 expression in EAE mice. Mol Neurobiol 57:3891\u20133901","journal-title":"Mol Neurobiol"},{"key":"10684_CR6","doi-asserted-by":"crossref","first-page":"113895","DOI":"10.1016\/j.expneurol.2021.113895","volume":"347","author":"J Zhang","year":"2022","unstructured":"Zhang J et al (2022) Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol 347:113895","journal-title":"Exp Neurol"},{"key":"10684_CR7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12026-019-09088-6","volume":"67","author":"L Ji","year":"2019","unstructured":"Ji L et al (2019) Comparison of Immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells. Immunol Res 67:432\u2013442","journal-title":"Immunol Res"},{"key":"10684_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8722-5-1","volume":"5","author":"S Wang","year":"2012","unstructured":"Wang S, Qu X, Zhao RC (2012) Clinical applications of mesenchymal stem cells. J Hematol Oncol 5:1\u20139","journal-title":"J Hematol Oncol"},{"issue":"9","key":"10684_CR9","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/term.2914","volume":"13","author":"C Brown","year":"2019","unstructured":"Brown C et al (2019) Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med 13(9):1738\u20131755","journal-title":"J Tissue Eng Regen Med"},{"issue":"37","key":"10684_CR10","doi-asserted-by":"crossref","first-page":"1909125","DOI":"10.1002\/adfm.201909125","volume":"30","author":"M\u00c1 Brennan","year":"2020","unstructured":"Brennan M\u00c1, Layrolle P, Mooney DJ (2020) Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration. Adv Funct Mater 30(37):1909125","journal-title":"Adv Funct Mater"},{"key":"10684_CR11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12026-017-8973-4","volume":"66","author":"M Khosravi","year":"2018","unstructured":"Khosravi M et al (2018) Induction of CD4\u2009+\u2009CD25\u2009+\u2009Foxp3\u2009+\u2009regulatory T cells by mesenchymal stem cells is associated with RUNX complex factors. Immunol Res 66:207\u2013218","journal-title":"Immunol Res"},{"issue":"17","key":"10684_CR12","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.3390\/ijms231710023","volume":"23","author":"Y Huang","year":"2022","unstructured":"Huang Y, Wu Q, Tam PKH (2022) Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications. Int J Mol Sci 23(17):10023","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10684_CR13","doi-asserted-by":"crossref","first-page":"e2101317","DOI":"10.1002\/adbi.202101317","volume":"6","author":"B Derkus","year":"2022","unstructured":"Derkus B et al (2022) Xenogenic neural stem cell-Derived extracellular nanovesicles modulate human mesenchymal stem cell fate and reconstruct metabolomic structure. Adv Biol (Weinh) 6(6):e2101317","journal-title":"Adv Biol (Weinh)"},{"issue":"3","key":"10684_CR14","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.intimp.2013.07.016","volume":"17","author":"F Yousefi","year":"2013","unstructured":"Yousefi F et al (2013) Comparison of in vivo Immunomodulatory effects of intravenous and intraperitoneal administration of adipose-tissue mesenchymal stem cells in experimental autoimmune encephalomyelitis (EAE). Int Immunopharmacol 17(3):608\u2013616","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10684_CR15","first-page":"75","volume":"14","author":"F Yousefi","year":"2012","unstructured":"Yousefi F et al (2012) Study of the effects of adipose-tissue mesenchymal stem cells and conditioned medium on cell infiltration in the brains of experimental autoimmune encephalomyelitis C57 BL\/6 mice. Pathobiology Res 14(4):75\u201388","journal-title":"Pathobiology Res"},{"issue":"2","key":"10684_CR16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(11)70305-2","volume":"11","author":"P Connick","year":"2012","unstructured":"Connick P et al (2012) Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 11(2):150\u2013156","journal-title":"Lancet Neurol"},{"key":"10684_CR17","unstructured":"Karussis D et al Pilot phase I\/II clinical trial with autologous mesenchymal stem cells in patients with multiple sclerosis. in Human Gene Therapy. 2010. MARY ANN LIEBERT INC 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA"},{"issue":"1\u20132","key":"10684_CR18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","volume":"227","author":"B Yamout","year":"2010","unstructured":"Yamout B et al (2010) Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 227(1\u20132):185\u2013189","journal-title":"J Neuroimmunol"},{"issue":"1","key":"10684_CR19","first-page":"50","volume":"4","author":"M Mohyeddin Bonab","year":"2007","unstructured":"Mohyeddin Bonab M et al (2007) Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study. Iran J Immunol 4(1):50\u201357","journal-title":"Iran J Immunol"},{"issue":"12","key":"10684_CR20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/cells8121659","volume":"8","author":"E Kuca-Warnawin","year":"2019","unstructured":"Kuca-Warnawin E et al (2019) The phenotype and secretory activity of adipose-derived mesenchymal stem cells (ASCs) of patients with rheumatic diseases. Cells 8(12):1659","journal-title":"Cells"},{"issue":"1","key":"10684_CR21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.15283\/ijsc17062","volume":"11","author":"A Sargent","year":"2018","unstructured":"Sargent A et al (2018) Transcriptional profiling of mesenchymal stem cells identifies distinct neuroimmune pathways altered by CNS disease. Int J Stem Cells 11(1):48\u201360","journal-title":"Int J Stem Cells"},{"issue":"8","key":"10684_CR22","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3727\/096368914X682792","volume":"24","author":"H Kim","year":"2015","unstructured":"Kim H et al (2015) Diabetic mesenchymal stem cells are ineffective for improving limb ischemia due to their impaired angiogenic capability. Cell Transpl 24(8):1571\u20131584","journal-title":"Cell Transpl"},{"key":"10684_CR23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.expneurol.2017.06.013","volume":"295","author":"A Sargent","year":"2017","unstructured":"Sargent A et al (2017) CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells. Exp Neurol 295:222\u2013232","journal-title":"Exp Neurol"},{"key":"10684_CR24","doi-asserted-by":"crossref","unstructured":"Alicka M et al (2019) Adipose-Derived mesenchymal stem cells isolated from patients with type 2 diabetes show reduced stemness through an altered secretome profile, impaired Anti-Oxidative protection, and mitochondrial dynamics deterioration. J Clin Med, 8(6)","DOI":"10.3390\/jcm8060765"},{"key":"10684_CR25","doi-asserted-by":"crossref","unstructured":"Hwang S et al (2023) Mesenchymal stromal cells primed by Toll-like receptors 3 and 4 enhanced Anti-Inflammatory effects against LPS-Induced macrophages via extracellular vesicles. Int J Mol Sci, 24(22)","DOI":"10.3390\/ijms242216264"},{"issue":"3","key":"10684_CR26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cmi.2015.11","volume":"13","author":"GY Liu","year":"2016","unstructured":"Liu GY et al (2016) Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells: implications for therapeutic potential. Cell Mol Immunol 13(3):369\u2013378","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"10684_CR27","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/nprot.2006.285","volume":"1","author":"IM Stromnes","year":"2006","unstructured":"Stromnes IM, Goverman JM (2006) Active induction of experimental allergic encephalomyelitis. Nat Protoc 1(4):1810\u20131819","journal-title":"Nat Protoc"},{"key":"10684_CR28","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.intimp.2018.12.009","volume":"67","author":"A Fathollahi","year":"2019","unstructured":"Fathollahi A et al (2019) In vitro analysis of Immunomodulatory effects of mesenchymal stem cell- and tumor cell -derived exosomes on recall antigen-specific responses. Int Immunopharmacol 67:302\u2013310","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"10684_CR29","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","volume":"30","author":"MW Pfaffl","year":"2002","unstructured":"Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30(9):e36","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10684_CR30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/1352458510371959","volume":"16","author":"E Mallam","year":"2010","unstructured":"Mallam E et al (2010) Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis. Multiple Scler J 16(8):909\u2013918","journal-title":"Multiple Scler J"},{"issue":"7","key":"10684_CR31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/1352458517711276","volume":"24","author":"J Redondo","year":"2018","unstructured":"Redondo J et al (2018) Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro. Multiple Scler J 24(7):919\u2013931","journal-title":"Multiple Scler J"},{"key":"10684_CR32","doi-asserted-by":"crossref","unstructured":"Vilahur G, Nguyen PH, Badimon L (2021) Impact of diabetes mellitus on the potential of autologous stem cells and stem Cell\u2013Derived microvesicles to repair the ischemic heart. Cardiovasc Drugs Ther,: p. 1\u201317","DOI":"10.1007\/s10557-021-07208-9"},{"key":"10684_CR33","doi-asserted-by":"crossref","first-page":"822772","DOI":"10.3389\/fcell.2022.822772","volume":"10","author":"X Wu","year":"2022","unstructured":"Wu X et al (2022) Adipose-derived stem cells from patients with ulcerative colitis exhibit impaired immunosuppressive function. Front Cell Dev Biology 10:822772","journal-title":"Front Cell Dev Biology"},{"issue":"17","key":"10684_CR34","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.3390\/ijms22179531","volume":"22","author":"L L\u00f3pez-Garc\u00eda","year":"2021","unstructured":"L\u00f3pez-Garc\u00eda L, Castro-Manrreza ME (2021) TNF-\u03b1 and IFN-\u03b3 participate in improving the immunoregulatory capacity of mesenchymal stem\/stromal cells: importance of cell\u2013cell contact and extracellular vesicles. Int J Mol Sci 22(17):9531","journal-title":"Int J Mol Sci"},{"key":"10684_CR35","doi-asserted-by":"crossref","first-page":"835345","DOI":"10.3389\/fimmu.2022.835345","volume":"13","author":"X Ling","year":"2022","unstructured":"Ling X et al (2022) IFN-\u03b3-Primed hUCMSCs significantly reduced inflammation via the Foxp3\/ROR-\u03b3t\/STAT3 signaling pathway in an animal model of multiple sclerosis. Front Immunol 13:835345","journal-title":"Front Immunol"},{"issue":"7","key":"10684_CR36","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/stem.1388","volume":"31","author":"L Wang","year":"2013","unstructured":"Wang L et al (2013) IFN-\u03b3 and TNF-\u03b1 synergistically induce mesenchymal stem cell impairment and tumorigenesis via NF\u03baB signaling. Stem Cells 31(7):1383\u20131395","journal-title":"Stem Cells"},{"issue":"5","key":"10684_CR37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2017.04.011","volume":"20","author":"L Garc\u00eda-Prat","year":"2017","unstructured":"Garc\u00eda-Prat L, Sousa-Victor P, Mu\u00f1oz-C\u00e1noves P (2017) Proteostatic and metabolic control of stemness. Cell Stem Cell 20(5):593\u2013608","journal-title":"Cell Stem Cell"},{"key":"10684_CR38","doi-asserted-by":"crossref","first-page":"870324","DOI":"10.3389\/fbioe.2022.870324","volume":"10","author":"X Peng","year":"2022","unstructured":"Peng X et al (2022) Inflammatory microenvironment accelerates bone marrow mesenchymal stem cell aging. Front Bioeng Biotechnol 10:870324","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"10684_CR39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3727\/096368913X675142","volume":"24","author":"GL De Oliveira","year":"2015","unstructured":"De Oliveira GL et al (2015) Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts. Cell Transplant 24(2):151\u2013165","journal-title":"Cell Transplant"},{"issue":"3","key":"10684_CR40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.56808\/3027-7922.2452","volume":"44","author":"F Maghsood","year":"2020","unstructured":"Maghsood F et al (2020) Conditioned medium of lipopolysaccharide-treated embryonic stem cell-derived mesenchymal stem cells modulates in vitro secretion of inflammatory cytokines. Thai J Pharm Sci 44(3):152\u2013158","journal-title":"Thai J Pharm Sci"},{"issue":"12","key":"10684_CR41","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.4049\/jimmunol.0803864","volume":"182","author":"R Romieu-Mourez","year":"2009","unstructured":"Romieu-Mourez R et al (2009) Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a Proinflammatory phenotype. J Immunol 182(12):7963\u20137973","journal-title":"J Immunol"},{"key":"10684_CR42","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3389\/fimmu.2019.00630","volume":"10","author":"R Mizuno","year":"2019","unstructured":"Mizuno R et al (2019) PD-1 primarily targets TCR signal in the Inhibition of functional T cell activation. Front Immunol 10:630","journal-title":"Front Immunol"},{"key":"10684_CR43","doi-asserted-by":"crossref","unstructured":"Ageeva T, Rizvanov A, Mukhamedshina Y (2024) NF-\u03baB and JAK\/STAT signaling pathways as crucial regulators of neuroinflammation and astrocyte modulation in spinal cord injury. Cells, 13(7)","DOI":"10.3390\/cells13070581"},{"issue":"3","key":"10684_CR44","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1096\/fj.201801845R","volume":"33","author":"T Lin","year":"2019","unstructured":"Lin T et al (2019) Trained murine mesenchymal stem cells have anti-inflammatory effect on macrophages, but defective regulation on T-cell proliferation. Faseb J 33(3):4203\u20134211","journal-title":"Faseb J"},{"issue":"2","key":"10684_CR45","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.immuni.2020.01.002","volume":"52","author":"AM McGinley","year":"2020","unstructured":"McGinley AM et al (2020) Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1\u03b2-Producing myeloid cells that promote pathogenic T cells. Immunity 52(2):342\u2013356e6","journal-title":"Immunity"},{"issue":"4","key":"10684_CR46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","volume":"9","author":"S Sanjabi","year":"2009","unstructured":"Sanjabi S et al (2009) Anti-inflammatory and pro-inflammatory roles of TGF-\u03b2, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9(4):447\u2013453","journal-title":"Curr Opin Pharmacol"},{"issue":"1 Supplement 1","key":"10684_CR47","first-page":"S2","volume":"74","author":"LH Kasper","year":"2010","unstructured":"Kasper LH, Shoemaker J (2010) Multiple sclerosis immunology: the healthy immune system vs the MS immune system. Neurology 74(1 Supplement 1):S2\u2013S8","journal-title":"Neurology"},{"key":"10684_CR48","doi-asserted-by":"crossref","first-page":"107207","DOI":"10.1016\/j.intimp.2020.107207","volume":"90","author":"A Fathollahi","year":"2021","unstructured":"Fathollahi A et al (2021) Intranasal administration of small extracellular vesicles derived from mesenchymal stem cells ameliorated the experimental autoimmune encephalomyelitis. Int Immunopharmacol 90:107207","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"10684_CR49","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00262-014-1581-4","volume":"63","author":"C Devaud","year":"2014","unstructured":"Devaud C, Darcy PK, Kershaw MH (2014) Foxp3 expression in T regulatory cells and other cell lineages. Cancer Immunol Immunother 63(9):869\u2013876","journal-title":"Cancer Immunol Immunother"},{"issue":"3","key":"10684_CR50","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.immuni.2011.08.012","volume":"35","author":"Y Wang","year":"2011","unstructured":"Wang Y, Su MA, Wan YY (2011) An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35(3):337\u2013348","journal-title":"Immunity"},{"issue":"8","key":"10684_CR51","doi-asserted-by":"crossref","first-page":"e0181868","DOI":"10.1371\/journal.pone.0181868","volume":"12","author":"G Castro","year":"2017","unstructured":"Castro G et al (2017) ROR\u03b3t and ROR\u03b1 signature genes in human Th17 cells. PLoS ONE 12(8):e0181868","journal-title":"PLoS ONE"},{"issue":"11","key":"10684_CR52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nri3536","volume":"13","author":"V Lazarevic","year":"2013","unstructured":"Lazarevic V, Glimcher LH, Lord GM (2013) T-bet: a Bridge between innate and adaptive immunity. Nat Rev Immunol 13(11):777\u2013789","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10684_CR53","doi-asserted-by":"crossref","first-page":"e108670","DOI":"10.1371\/journal.pone.0108670","volume":"9","author":"C Devaud","year":"2014","unstructured":"Devaud C et al (2014) Foxp3 expression in macrophages associated with RENCA tumors in mice. PLoS ONE 9(9):e108670","journal-title":"PLoS ONE"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10684-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10684-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10684-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T16:30:55Z","timestamp":1766853055000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10684-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10684"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10684-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2025,6,11]]},"assertion":[{"value":"23 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics and Research Committee of Shahid Beheshti University of Medical Sciences (ethical approval code: IR.SBMU.MSP.REC.1400.142).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"582"}}