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We discuss the mechanisms of PrAT activity, its involvement in reduction\u2013oxidation (redox) homeostasis, and the rationale for its potential as a drug target against ESKAPE pathogens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Expert opinion<\/jats:title>\n                    <jats:p>PrAT plays an essential role in sustaining the bacterium\u2019s redox homeostasis, a vital aspect of bacterial survival, by interacting with glutaredoxin (Grx). Future research should focus on elucidating the specific role of PrAT in ESKAPE pathogens, with an emphasis on studying the enzyme\u2019s function and designing targeted inhibitors. This review underscores the importance of continued investigation into PrAT in ESKAPE pathogens as a critical step in addressing the challenges of antimicrobial resistance in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-025-10735-5","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T13:18:22Z","timestamp":1751894302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring protein adenylyltransferase as a therapeutic target for combating ESKAPE pathogens in hospital-acquired infections"],"prefix":"10.1007","volume":"52","author":[{"given":"Reabetswe","family":"Maake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Otun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"Achilonu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"10735_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhin.2024.04.015","volume":"150","author":"G Hutton","year":"2024","unstructured":"Hutton G, Chase C, Kennedy-Walker R, Hamilton H (2024) Financial and economic costs of healthcare-associated infections in Africa. 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