{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:39:51Z","timestamp":1775741991819,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Collaborative Innovation Center of Chinese Ministry of Education","award":["2020-39"],"award-info":[{"award-number":["2020-39"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82360445"],"award-info":[{"award-number":["82360445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research and Talent Training Funds of Kweichow Moutai Hospital","award":["2022-13"],"award-info":[{"award-number":["2022-13"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10794-8","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:05:40Z","timestamp":1753254340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Personalized human umbilical cord mesenchymal stem cell-derived exosome pre-treatment based on the simulation of scar microenvironment characteristics: a promising approach for early scar treatment"],"prefix":"10.1007","volume":"52","author":[{"given":"Hailian","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zairong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"5","key":"10794_CR1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/iwj.13988","volume":"20","author":"S Li","year":"2023","unstructured":"Li S, Ding H, Yang Y et al (2023) Global research status of pathological scar reported over the period 2001\u20132021: A 20-year bibliometric analysis. Int Wound J 20(5):1725\u20131738","journal-title":"Int Wound J"},{"issue":"609","key":"10794_CR2","doi-asserted-by":"crossref","first-page":"eabb3312","DOI":"10.1126\/scitranslmed.abb3312","volume":"13","author":"MF Griffin","year":"2021","unstructured":"Griffin MF, Borrelli MR, Garcia JT et al (2021) JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models. Sci Transl Med 13(609):eabb3312","journal-title":"Sci Transl Med"},{"issue":"1","key":"10794_CR3","first-page":"36","volume":"10","author":"JY Ding","year":"2023","unstructured":"Ding JY, Chen MJ, Wu LF et al (2023) Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges. Mil Med Res 10(1):36","journal-title":"Mil Med Res"},{"issue":"5","key":"10794_CR4","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.7150\/ijbs.80430","volume":"19","author":"G Yang","year":"2023","unstructured":"Yang G, Waheed S, Wang C et al (2023) Exosomes and their bioengineering strategies in the cutaneous wound healing and related complications: current knowledge and future perspectives. Int J Biol Sci 19(5):1430\u20131454","journal-title":"Int J Biol Sci"},{"issue":"2","key":"10794_CR5","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles 13(2):e12404","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"10794_CR6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","volume":"14","author":"A Lotfy","year":"2023","unstructured":"Lotfy A, Aboquella NM, Wang H (2023) Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther 14(1):66","journal-title":"Stem Cell Res Ther"},{"key":"10794_CR7","doi-asserted-by":"crossref","first-page":"32993","DOI":"10.1038\/srep32993","volume":"6","author":"L Hu","year":"2016","unstructured":"Hu L, Wang J, Zhou X et al (2016) Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep 6:32993","journal-title":"Sci Rep"},{"issue":"15","key":"10794_CR8","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.7150\/thno.73436","volume":"12","author":"ME Al-Masawa","year":"2022","unstructured":"Al-Masawa ME, Alshawsh MA, Ng CY et al (2022) Efficacy and safety of small extracellular vesicle interventions in wound healing and skin regeneration: a systematic review and meta-analysis of animal studies. Theranostics 12(15):6455\u20136508","journal-title":"Theranostics"},{"issue":"9","key":"10794_CR9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1089\/scd.2016.0349","volume":"26","author":"GD Kusuma","year":"2017","unstructured":"Kusuma GD, Carthew J, Lim R et al (2017) Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect. Stem Cells Dev 26(9):617\u2013631","journal-title":"Stem Cells Dev"},{"issue":"1","key":"10794_CR10","doi-asserted-by":"crossref","first-page":"13321","DOI":"10.1038\/s41598-017-12919-x","volume":"7","author":"L Wang","year":"2017","unstructured":"Wang L, Hu L, Zhou X et al (2017) Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep 7(1):13321","journal-title":"Sci Rep"},{"issue":"12","key":"10794_CR11","volume":"8","author":"JK Lee","year":"2013","unstructured":"Lee JK, Park SR, Jung BK et al (2013) Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS ONE 8(12):e84256","journal-title":"PLoS ONE"},{"issue":"5","key":"10794_CR12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s13402-017-0335-7","volume":"40","author":"K Pakravan","year":"2017","unstructured":"Pakravan K, Babashah S, Sadeghizadeh M et al (2017) MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR\/HIF-1\u03b1\/VEGF signaling axis in breast cancer cells. Cell Oncol (Dordr) 40(5):457\u2013470","journal-title":"Cell Oncol (Dordr)"},{"key":"10794_CR13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122647","volume":"346","author":"M Strecanska","year":"2024","unstructured":"Strecanska M, Sekelova T, Csobonyeiova M et al (2024) Therapeutic applications of mesenchymal\/medicinal stem\/signaling cells preconditioned with external factors: Are there more efficient approaches to utilize their regenerative potential? Life Sci 346:122647","journal-title":"Life Sci"},{"key":"10794_CR14","first-page":"1779346","volume":"2022","author":"S Chen","year":"2022","unstructured":"Chen S, Sun F, Qian H et al (2022) Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Therapy. Stem Cells Int 2022:1779346","journal-title":"Stem Cells Int"},{"issue":"2","key":"10794_CR15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/ijms22020763","volume":"22","author":"V Miceli","year":"2021","unstructured":"Miceli V, Bulati M, Iannolo G et al (2021) Therapeutic properties of mesenchymal stromal\/stem cells: the need of cell priming for cell-free therapies in regenerative medicine. Int J Mol Sci 22(2):763","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10794_CR16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40580-022-00349-z","volume":"9","author":"JY Kim","year":"2022","unstructured":"Kim JY, Rhim WK, Cha SG et al (2022) Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media. Nano Converg 9(1):57","journal-title":"Nano Converg"},{"issue":"11","key":"10794_CR17","first-page":"1024","volume":"36","author":"H Yi","year":"2020","unstructured":"Yi H, Qinxin Y, Qi W et al (2020) Research on feasibility of in vitro inflammatory wound microenvironment simulated by using inflam-matory wound tissue homogenate of mice. Chin J Burns 36(11):1024\u20131034","journal-title":"Chin J Burns"},{"key":"10794_CR18","unstructured":"QI W (2020) Effect of the microenvironment on the biological effects of hUC-MSCs-Exos during the plastic stage of wound healing"},{"issue":"4","key":"10794_CR19","first-page":"324","volume":"35","author":"W Zairong","year":"2019","unstructured":"Zairong W, Dali W (2019) MSCs in wound repair - extracellular vesicles exosome microenvironment hypothesis. Chin J Plast Surg 35(4):324\u2013330","journal-title":"Chin J Plast Surg"},{"issue":"11","key":"10794_CR20","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni.3002","volume":"15","author":"Y Wang","year":"2014","unstructured":"Wang Y, Chen X, Cao W et al (2014) Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol 15(11):1009\u20131016","journal-title":"Nat Immunol"},{"issue":"1","key":"10794_CR21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/stem.2730","volume":"36","author":"MT Harting","year":"2018","unstructured":"Harting MT, Srivastava AK, Zhaorigetu S et al (2018) Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation. Stem Cells 36(1):79\u201390","journal-title":"Stem Cells"},{"issue":"1","key":"10794_CR22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/scd.2016.0209","volume":"26","author":"L Barrachina","year":"2017","unstructured":"Barrachina L, Remacha AR, Romero A et al (2017) Priming equine bone marrow-derived mesenchymal stem cells with proinflammatory cytokines: implications in immunomodulation-immunogenicity balance, cell viability, and differentiation potential. Stem Cells Dev 26(1):15\u201324","journal-title":"Stem Cells Dev"},{"issue":"1","key":"10794_CR23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4142\/jvs.2017.18.1.39","volume":"18","author":"L Barrachina","year":"2017","unstructured":"Barrachina L, Remacha AR, Romero A et al (2017) Inflammation affects the viability and plasticity of equine mesenchymal stem cells: possible implications in intra-articular treatments. J Vet Sci 18(1):39\u201349","journal-title":"J Vet Sci"},{"issue":"3","key":"10794_CR24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/ijms18030606","volume":"18","author":"R Ogawa","year":"2017","unstructured":"Ogawa R (2017) Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 18(3):606","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10794_CR25","first-page":"20","volume":"8","author":"W Xi-Qiao","year":"2013","unstructured":"Xi-Qiao W, Fei S, Xuelian C et al (2013) Change of the micro vascular permeability during hypertrophic scar formation and regression. Chin J Injury Repair and Wound Healing (Electronic Edition) 8(1):20\u201322","journal-title":"Chin J Injury Repair and Wound Healing (Electronic Edition)"},{"issue":"10","key":"10794_CR26","first-page":"582","volume":"32","author":"C Lu","year":"2016","unstructured":"Lu C, Dali W, Zairong W et al (2016) Effects of local transplantation of autologous adipose-derived mesenchymal stem cells on the formation of hyperplastic scar on rabbit ears. Chin J Burns 32(10):582\u2013587","journal-title":"Chin J Burns"},{"issue":"1","key":"10794_CR27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13287-018-1104-x","volume":"10","author":"J Ma","year":"2019","unstructured":"Ma J, Wu J, Han L et al (2019) Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord, and chorionic plate under serum-free condition. Stem Cell Res Ther 10(1):19","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"10794_CR28","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.5114\/aoms.2017.70878","volume":"14","author":"H Ma","year":"2018","unstructured":"Ma H, Zhang S, Xu Y et al (2018) Analysis of differentially expressed microRNA of TNF-\u03b1-stimulated mesenchymal stem cells and exosomes from their culture supernatant. Arch Med Sci 14(5):1102\u20131111","journal-title":"Arch Med Sci"},{"issue":"5","key":"10794_CR29","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/stem.2564","volume":"35","author":"Y Song","year":"2017","unstructured":"Song Y, Dou H, Li X et al (2017) Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1\u03b2-primed mesenchymal stem cells against sepsis. Stem Cells 35(5):1208\u20131221","journal-title":"Stem Cells"},{"issue":"6","key":"10794_CR30","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers13061351","volume":"13","author":"N Ganig","year":"2021","unstructured":"Ganig N, Baenke F, Thepkaysone ML et al (2021) Proteomic analyses of fibroblast- and serum-derived exosomes identify QSOX1 as a marker for non-invasive detection of colorectal cancer. Cancers 13(6):1351","journal-title":"Cancers"},{"issue":"3","key":"10794_CR31","first-page":"793","volume":"60","author":"R \u0162u\u0163uianu","year":"2019","unstructured":"\u0162u\u0163uianu R, Ro\u015fca AM, Florea G et al (2019) Heterogeneity of human fibroblasts isolated from hypertrophic scar. Rom J Morphol Embryol 60(3):793\u2013802","journal-title":"Rom J Morphol Embryol"},{"issue":"20","key":"10794_CR32","first-page":"10790","volume":"24","author":"YD Ba","year":"2020","unstructured":"Ba YD, Sun JH, Zhao XX (2020) Evogliptin attenuates bleomycin-induced lung fibrosis via inhibiting TGF-\u03b2\/Smad signaling in fibroblast. Eur Rev Med Pharmacol Sci 24(20):10790\u201310798","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10794_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10103-018-2567-9","volume":"34","author":"B Han","year":"2019","unstructured":"Han B, Fan J, Liu L et al (2019) Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-\u03b21 and Notch-1 expression enhanced by photobiomodulation therapy. Lasers Med Sci 34(1):1\u201310","journal-title":"Lasers Med Sci"},{"issue":"4","key":"10794_CR34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1089\/wound.2012.0393","volume":"2","author":"van de Water L, Varney S, Tomasek J J","year":"2013","unstructured":"van de Water L, Varney S, Tomasek J J (2013) Mechanoregulation of the myofibroblast in wound contraction, scarring, and fibrosis: opportunities for new therapeutic intervention. Adv Wound Care (New Rochelle) 2(4):122\u2013141","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"1","key":"10794_CR35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008668","volume":"5","author":"M Daigneault","year":"2010","unstructured":"Daigneault M, Preston JA, Marriott HM et al (2010) The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS ONE 5(1):e8668","journal-title":"PLoS ONE"},{"issue":"2","key":"10794_CR36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5578\/mb.66745","volume":"52","author":"D Biriken","year":"2018","unstructured":"Biriken D, Yaz\u0131han N, Y\u0131lmaz \u015e (2018) Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times. Mikrobiyol Bul 52(2):147\u201355","journal-title":"Mikrobiyol Bul"},{"key":"10794_CR37","volume":"12","author":"SP Cass","year":"2021","unstructured":"Cass SP, Mekhael O, Thayaparan D et al (2021) Increased monocyte-derived CD11b(+) macrophage subpopulations following cigarette smoke exposure are associated with impaired bleomycin-induced tissue remodelling. Front Immunol 12:740330","journal-title":"Front Immunol"},{"issue":"9","key":"10794_CR38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/term.3229","volume":"15","author":"F Scopelliti","year":"2021","unstructured":"Scopelliti F, Caterina C, Valentina D et al (2021) Platelet lysate converts M (IFN\u03b3+LPS) macrophages in CD206(+) TGF-\u03b2(+) arginase(+) M2-like macrophages that affect fibroblast activity and T lymphocyte migration. J Tissue Eng Regen Med 15(9):788\u2013797","journal-title":"J Tissue Eng Regen Med"},{"issue":"7","key":"10794_CR39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2174\/1566524020666200106095745","volume":"20","author":"J Ma","year":"2020","unstructured":"Ma J, Yan X, Lin Y et al (2020) Hepatocyte growth factor secreted from human adipose-derived stem cells inhibits fibrosis in hypertrophic scar fibroblasts. Curr Mol Med 20(7):558\u2013571","journal-title":"Curr Mol Med"},{"key":"10794_CR40","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3389\/fimmu.2018.02837","volume":"9","author":"JR Ferreira","year":"2018","unstructured":"Ferreira JR, Teixeira GQ, Santos SG et al (2018) Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning. Front Immunol 9:2837","journal-title":"Front Immunol"},{"issue":"1","key":"10794_CR41","first-page":"1","volume":"9","author":"E Francis","year":"2019","unstructured":"Francis E, Kearney L, Clover J (2019) The effects of stem cells on burn wounds: a review. Int J Burns Trauma 9(1):1\u201312","journal-title":"Int J Burns Trauma"},{"issue":"1","key":"10794_CR42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13287-018-0977-z","volume":"9","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Xiang W, Yi DY et al (2018) Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas. Stem Cell Res Ther 9(1):228","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10794_CR43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13287-021-02697-9","volume":"13","author":"D Bian","year":"2022","unstructured":"Bian D, Wu Y, Song G et al (2022) The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review. Stem Cell Res Ther 13(1):24","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10794_CR44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13287-021-02290-0","volume":"12","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang J, Shi J et al (2021) Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p\/IL-17RA\/Smad axis. Stem Cell Res Ther 12(1):221","journal-title":"Stem Cell Res Ther"},{"issue":"16","key":"10794_CR45","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.21037\/atm-21-3557","volume":"9","author":"D Shen","year":"2021","unstructured":"Shen D, He Z (2021) Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after myocardial reperfusion injury. Ann Transl Med 9(16):1323","journal-title":"Ann Transl Med"},{"key":"10794_CR46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fphys.2018.00419","volume":"9","author":"P Krzyszczyk","year":"2018","unstructured":"Krzyszczyk P, Schloss R, Palmer A et al (2018) The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol 9:419","journal-title":"Front Physiol"},{"issue":"1","key":"10794_CR47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/s13287-021-02517-0","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Pan Y, Liu Y et al (2021) Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-\u03b2 receptor inhibition. Stem Cell Res Ther 12(1):434","journal-title":"Stem Cell Res Ther"},{"issue":"6326","key":"10794_CR48","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.aai8792","volume":"355","author":"MV Plikus","year":"2017","unstructured":"Plikus MV, Guerrero-Juarez CF, Ito M et al (2017) Regeneration of fat cells from myofibroblasts during wound healing. Science 355(6326):748\u2013752","journal-title":"Science"},{"key":"10794_CR49","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ebiom.2016.04.030","volume":"8","author":"X Li","year":"2016","unstructured":"Li X, Liu L, Yang J et al (2016) Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation. EBioMedicine 8:72\u201382","journal-title":"EBioMedicine"},{"key":"10794_CR50","volume":"264","author":"M Yao","year":"2021","unstructured":"Yao M, Cui B, Zhang W et al (2021) Exosomal miR-21 secreted by IL-1\u03b2-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis. Life Sci 264:118658","journal-title":"Life Sci"},{"key":"10794_CR51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","volume":"122","author":"Y Nakao","year":"2021","unstructured":"Nakao Y, Fukuda T, Zhang Q et al (2021) Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater 122:306\u2013324","journal-title":"Acta Biomater"},{"issue":"2","key":"10794_CR52","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/iwj.13041","volume":"16","author":"L Chen","year":"2019","unstructured":"Chen L, Wang J, Li S et al (2019) The clinical dynamic changes of macrophage phenotype and function in different stages of human wound healing and hypertrophic scar formation. Int Wound J 16(2):360\u2013369","journal-title":"Int Wound J"},{"issue":"1","key":"10794_CR53","doi-asserted-by":"crossref","first-page":"16875","DOI":"10.1038\/s41598-017-17061-2","volume":"7","author":"S Sedrakyan","year":"2017","unstructured":"Sedrakyan S, Villani V, da Sacco S et al (2017) Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep 7(1):16875","journal-title":"Sci Rep"},{"issue":"5","key":"10794_CR54","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5966\/sctm.2014-0267","volume":"4","author":"B Zhang","year":"2015","unstructured":"Zhang B, Wu X, Zhang X et al (2015) Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4\/\u03b2-catenin pathway. Stem Cells Transl Med 4(5):513\u2013522","journal-title":"Stem Cells Transl Med"},{"issue":"6","key":"10794_CR55","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3390\/cells10061316","volume":"10","author":"I Maldonado-Lasunci\u00f3n","year":"2021","unstructured":"Maldonado-Lasunci\u00f3n I, Haggerty AE, Okuda A et al (2021) The effect of inflammatory priming on the therapeutic potential of mesenchymal stromal cells for spinal cord repai. Cells 10(6):1316","journal-title":"Cells"},{"issue":"1","key":"10794_CR56","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1038\/s41598-024-60928-4","volume":"14","author":"S Kurawaki","year":"2024","unstructured":"Kurawaki S, Nakashima A, Ishiuchi N et al (2024) Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction. Sci Rep 14(1):10251","journal-title":"Sci Rep"},{"issue":"1","key":"10794_CR57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","volume":"16","author":"B Hinz","year":"2020","unstructured":"Hinz B, Lagares D (2020) Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nat Rev Rheumatol 16(1):11\u201331","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"10794_CR58","first-page":"26215","volume":"15","author":"B Wang","year":"2023","unstructured":"Wang B, Zhang S, Cheng A et al (2023) soluble polymer microneedles loaded with interferon alpha 1b for treatment of hyperplastic scar. Polymers (Basel) 15(12):26215","journal-title":"Polymers (Basel)"},{"key":"10794_CR59","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.lfs.2015.01.042","volume":"127","author":"J Lu","year":"2015","unstructured":"Lu J, Shi J, Li M et al (2015) Activation of AMPK by metformin inhibits TGF-\u03b2-induced collagen production in mouse renal fibroblasts. Life Sci 127:59\u201365","journal-title":"Life Sci"},{"issue":"6","key":"10794_CR60","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","volume":"12","author":"XM Meng","year":"2016","unstructured":"Meng XM, Nikolic-Paterson DJ, Lan HY (2016) TGF-\u03b2: the master regulator of fibrosis. Nat Rev Nephrol 12(6):325\u2013338","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"10794_CR61","first-page":"101","volume":"39","author":"W Dali","year":"2023","unstructured":"Dali W (2023) Viewpoint on the correlation of mesenchymal stem cell exosomes with wound microenvironment. Chin J Burns Wounds 39(2):101\u2013105","journal-title":"Chin J Burns Wounds"},{"key":"10794_CR62","doi-asserted-by":"crossref","first-page":"1291016","DOI":"10.3389\/fcell.2023.1291016","volume":"11","author":"S Cavallero","year":"2023","unstructured":"Cavallero S, Dekali S, Guitard N et al (2023) Effects of preconditioning with TNF\u03b1 and IFN\u03b3 in angiogenic potential of mesenchymal stromal cell-derived extracellular vesicles. Front Cell Dev Biol 11:1291016","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10794_CR63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101530","volume":"298","author":"L Moretti","year":"2022","unstructured":"Moretti L, Stalfort J, Barker TH et al (2022) The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation. J Biol Chem 298(2):101530","journal-title":"J Biol Chem"},{"key":"10794_CR64","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.actbio.2023.06.041","volume":"168","author":"A Vilar","year":"2023","unstructured":"Vilar A, Hodgson-Garms M, Kusuma GD et al (2023) Substrate mechanical properties bias MSC paracrine activity and therapeutic potential. Acta Biomater 168:144\u2013158","journal-title":"Acta Biomater"},{"issue":"10","key":"10794_CR65","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1016\/j.apsb.2024.06.027","volume":"14","author":"K Lv","year":"2024","unstructured":"Lv K, Wu T, Liu S et al (2024) Disease-derived circulating extracellular vesicle preconditioning: a promising strategy for precision mesenchymal stem cell therapy. Acta Pharm Sin B 14(10):4526\u20134543","journal-title":"Acta Pharm Sin B"},{"key":"10794_CR66","first-page":"7921760","volume":"2019","author":"JS Heo","year":"2019","unstructured":"Heo JS, Choi Y, Kim HO (2019) Adipose-derived mesenchymal stem cells promote M2 macrophage phenotype through exosomes. Stem Cells Int 2019:7921760","journal-title":"Stem Cells Int"},{"issue":"2","key":"10794_CR67","doi-asserted-by":"crossref","first-page":"851","DOI":"10.14336\/AD.2023.0719-1","volume":"15","author":"R Xue","year":"2024","unstructured":"Xue R, Xie M, Wu Z et al (2024) Mesenchymal stem cell-derived exosomes promote recovery of the facial nerve injury through regulating macrophage M1 and M2 polarization by targeting the P38 MAPK\/NF-\u039ab pathway. Aging Dis 15(2):851\u2013868","journal-title":"Aging Dis"},{"key":"10794_CR68","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.2147\/JIR.S308405","volume":"14","author":"YH Chen","year":"2021","unstructured":"Chen YH, Dong RN, Hou J et al (2021) mesenchymal stem cell-derived exosomes induced by IL-1\u03b2 attenuate urethral stricture through Let-7c\/PAK1\/NF-\u03baB-regulated macrophage M2 polarization. J Inflamm Res 14:3217\u20133229","journal-title":"J Inflamm Res"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10794-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:26:08Z","timestamp":1766895968000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10794-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10794"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10794-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"30 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The study was approved by the Medical Ethics Committee of the Affiliated Hospital of Zunyi Medical University (KLLY-2020\u2013061). The umbilical cord tissue was collected in the operating theatres of the Affiliated Hospital of Zunyi Medical University. The umbilical cord is classified as medical waste, and its collection is considered to be harmless to both mother and infant. Prior to the collection, the mother and the attending physician have provided verbal informed consent, and no written signature is required. All animal experiments were conducted in strict accordance with the \"Guiding Principles in the Care and Use of Animals\" (China). the study was approved by the Animal Care and Use Committee (ACUC) of Zunyi Medical University (ethics approval number: KLLY(A)-2020\u2013122). All procedures were designed to minimize the number of animals used and to ensure their welfare throughout the study. The animal production and use licenses were obtained as required by the regulations, and the experiments were performed under the supervision of the committee to ensure ethical standards were maintained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"747"}}