{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:39:50Z","timestamp":1793299190252,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10872-x","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T13:00:48Z","timestamp":1754053248000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic regulation of TIMP-3 expression in human macrophages via physiological and pharmacological modification of histone3 lysine27 (H3K27)"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-0084","authenticated-orcid":false,"given":"G\u00f6k\u00e7e","family":"Y\u0131ld\u0131r\u0131m-Buharal\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-7394","authenticated-orcid":false,"given":"Graciela B.","family":"Sala-Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-278X","authenticated-orcid":false,"given":"Mark","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9204","authenticated-orcid":false,"given":"Andrew C.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"10872_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.smim.2015.10.003","volume":"27","author":"C Porta","year":"2015","unstructured":"Porta C, Riboldi E, Ippolito A, Sica A (2015) Molecular and epigenetic basis of macrophage polarized activation. Semin Immunol 27:237\u2013248. https:\/\/doi.org\/10.1016\/j.smim.2015.10.003","journal-title":"Semin Immunol"},{"key":"10872_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fimmu.2011.00052","volume":"2","author":"A Kennedy","year":"2011","unstructured":"Kennedy A, Fearon U, Veale DJ et al (2011) Macrophages in synovial inflammation. Front Immunol 2:52. https:\/\/doi.org\/10.3389\/fimmu.2011.00052","journal-title":"Front Immunol"},{"key":"10872_CR3","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1161\/ATVBAHA.113.301453","volume":"33","author":"D Tugal","year":"2013","unstructured":"Tugal D, Liao X, Jain MK (2013) Transcriptional control of macrophage polarization. Arterioscler Thromb Vasc Biol 33:1135\u20131144. https:\/\/doi.org\/10.1161\/ATVBAHA.113.301453","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10872_CR4","doi-asserted-by":"publisher","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","volume":"877","author":"C Yunna","year":"2020","unstructured":"Yunna C, Mengru H, Lei W, Weidong C (2020) Macrophage M1\/M2 polarization. Eur J Pharmacol 877:173090. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173090","journal-title":"Eur J Pharmacol"},{"issue":"15","key":"10872_CR5","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1182\/blood-2009-04-217620","volume":"114","author":"M Ishii","year":"2009","unstructured":"Ishii M, Wen H, Corsa CAS et al (2009) Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114(15):3244\u20133254. https:\/\/doi.org\/10.1182\/blood-2009-04-217620","journal-title":"Blood"},{"key":"10872_CR6","doi-asserted-by":"publisher","first-page":"78045","DOI":"10.1371\/journal.pone.0078045","volume":"8","author":"NA Kittan","year":"2013","unstructured":"Kittan NA, Allen RM, Dhaliwal A et al (2013) Cytokine induced phenotypic and epigenetic signatures are key to Establishing specific macrophage phenotypes. PLoS ONE 8:78045. https:\/\/doi.org\/10.1371\/journal.pone.0078045","journal-title":"PLoS ONE"},{"issue":"23","key":"10872_CR7","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1101\/gad.175950.111","volume":"25","author":"SE Mullican","year":"2011","unstructured":"Mullican SE, Gaddis CA, Alenghat T et al (2011) Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev 25(23):2480\u20132488. https:\/\/doi.org\/10.1101\/gad.175950.111","journal-title":"Genes Dev"},{"issue":"7163","key":"10872_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nature06145","volume":"449","author":"K Agger","year":"2007","unstructured":"Agger K, Cloos PAC, Christensen J et al (2007) UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449(7163):731\u2013734. https:\/\/doi.org\/10.1038\/nature06145","journal-title":"Nature"},{"key":"10872_CR9","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3389\/fimmu.2018.02272","volume":"9","author":"Y Pan","year":"2018","unstructured":"Pan Y, Wang J, Xue Y et al (2018) GSKJ4 protects mice against early sepsis via reducing Proinflammatory factors and Up-Regulating MiR-146a. Front Immunol 9:2272. https:\/\/doi.org\/10.3389\/fimmu.2018.02272","journal-title":"Front Immunol"},{"issue":"4","key":"10872_CR10","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1002\/tox.23725","volume":"38","author":"Y Gao","year":"2022","unstructured":"Gao Y, Wang N, Jia| D (2022) JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation. Environ Toxicol 38(4):754\u2013769. https:\/\/doi.org\/10.1002\/tox.23725","journal-title":"Environ Toxicol"},{"key":"10872_CR11","doi-asserted-by":"publisher","unstructured":"Zhang Z-Y, Schluesener HJHDAC, Inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis. Prostate 72(1):90\u201399:. https:\/\/doi.org\/10.1002\/pros.21410","DOI":"10.1002\/pros.21410"},{"key":"10872_CR12","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1161\/ATVBAHA.108.173898","volume":"28","author":"AC Newby","year":"2008","unstructured":"Newby AC (2008) Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol 28:2108\u20132114. https:\/\/doi.org\/10.1161\/ATVBAHA.108.173898","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10872_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.critrevonc.2003.09.008","volume":"49","author":"E Lambert","year":"2004","unstructured":"Lambert E, Dass\u00e9 E, Haye B, Petitfr\u00e8re E (2004) TIMPs as multifacial proteins. Crit Rev Oncol Hematol 49:187\u2013198. https:\/\/doi.org\/10.1016\/j.critrevonc.2003.09.008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10872_CR14","doi-asserted-by":"publisher","first-page":"42507","DOI":"10.1371\/journal.pone.0042507","volume":"7","author":"W-C Huang","year":"2012","unstructured":"Huang W-C, Sala-Newby GB, Susana A et al (2012) Classical macrophage activation Up-Regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear Factor-kB. PLoS ONE 7:42507. https:\/\/doi.org\/10.1371\/journal.pone.0042507","journal-title":"PLoS ONE"},{"key":"10872_CR15","doi-asserted-by":"publisher","first-page":"276457","DOI":"10.1155\/2014\/276457","volume":"2014","author":"JL Johnson","year":"2014","unstructured":"Johnson JL, Jenkins NP, Huang W-C et al (2014) Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability. Mediators Inflamm 2014:276457. https:\/\/doi.org\/10.1155\/2014\/276457","journal-title":"Mediators Inflamm"},{"issue":"9","key":"10872_CR16","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1161\/ATVBAHA.108.170548","volume":"28","author":"JL Johnson","year":"2008","unstructured":"Johnson JL, Sala-Newby GB, Ismail Y et al (2008) Low tissue inhibitor of metalloproteinases 3 and high matrix metalloproteinase 14 levels defines a subpopulation of highly invasive Foam-Cell macrophages. Arterioscler Thromb Vasc Biol 28(9):1647\u20131653. https:\/\/doi.org\/10.1161\/ATVBAHA.108.170548","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10872_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1161\/CIRCRESAHA.116.309321","volume":"120","author":"K Di Gregoli","year":"2017","unstructured":"Di Gregoli K, Najmi N, Anuar M et al (2017) MicroRNA-181b controls atherosclerosis and aneurysms through regulation of TIMP-3 and Elastin. Circ Res 120:49\u201365. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.309321","journal-title":"Circ Res"},{"key":"10872_CR18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41598-024-51243-z","volume":"14","author":"Z Li","year":"2024","unstructured":"Li Z, Huang J, Yang L et al (2024) WNTA5-mediated miR-374a-5p regulates vascular smooth muscle cell phenotype transformation and M1 macrophage polarization impacting intracranial aneurysm progression. Sci Rep| 14:559. https:\/\/doi.org\/10.1038\/s41598-024-51243-z","journal-title":"Sci Rep|"},{"key":"10872_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fimmu.2017.00092","volume":"8","author":"G Y\u0131ld\u0131r\u0131m-Buharal\u0131o\u011flu","year":"2017","unstructured":"Y\u0131ld\u0131r\u0131m-Buharal\u0131o\u011flu G, Bond M, Sala-Newby GB et al (2017) Regulation of epigenetic modifiers, including KDM6B, by Interferon-\u03b3 and Interleukin-4 in human macrophages. Front Immunol 8:92. https:\/\/doi.org\/10.3389\/fimmu.2017.00092","journal-title":"Front Immunol"},{"key":"10872_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.2144\/19962003470","volume":"20","author":"CJ Elferink","year":"1996","unstructured":"Elferink CJ, Reiners JJ (1996) Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: A surrogate for the in vitro transcription Run-On assay. Biotechniques 20:470\u2013477. https:\/\/doi.org\/10.2144\/19962003470","journal-title":"Biotechniques"},{"key":"10872_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2302\/kjm.60.47","volume":"60","author":"H Nakajima","year":"2011","unstructured":"Nakajima H (2011) Role of transcription factors in differentiation and reprogramming of hematopoietic cells. Keio J Med 60:47\u201355. https:\/\/doi.org\/10.2302\/kjm.60.47","journal-title":"Keio J Med"},{"key":"10872_CR22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/JCP.20228","volume":"203","author":"HY Qureshi","year":"2005","unstructured":"Qureshi HY, Sylvester J, El Mabrouk M, Zafarullah M (2005) TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor. J Cell Physiol 203:345\u2013352. https:\/\/doi.org\/10.1002\/JCP.20228","journal-title":"J Cell Physiol"},{"key":"10872_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.gene.2013.01.001","volume":"517","author":"D Yan","year":"2013","unstructured":"Yan D, Chen D, Hawse JR et al (2013) Bovine lactoferricin induces TIMP-3 via the ERK1\/2-Sp1 axis in human articular chondrocytes. Gene 517:12\u201318. https:\/\/doi.org\/10.1016\/j.gene.2013.01.001","journal-title":"Gene"},{"key":"10872_CR24","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N et al (2010) Simple combinations of Lineage-Determining transcription factors prime cis-Regulatory elements required for macrophage and B cell identities. Mol Cell 38:576\u2013589. https:\/\/doi.org\/10.1016\/j.molcel.2010.05.004","journal-title":"Mol Cell"},{"issue":"5","key":"10872_CR25","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/ijc.22751","volume":"121","author":"T Beckers","year":"2007","unstructured":"Beckers T, Burkhardt C, Wieland H et al (2007) Distinct Pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int J Cancer 121(5):1138\u20131148. https:\/\/doi.org\/10.1002\/ijc.22751","journal-title":"Int J Cancer"},{"key":"10872_CR26","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3389\/fphys.2020.00661","volume":"11","author":"D Fan","year":"2020","unstructured":"Fan D, Kassiri Z (2020) Biology of tissue inhibitor of metalloproteinase 3 (TIMP3), and its therapeutic implications in cardiovascular pathology. Front Physiol 11:661. https:\/\/doi.org\/10.3389\/fphys.2020.00661","journal-title":"Front Physiol"},{"key":"10872_CR27","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/hep.32184","volume":"75","author":"J Rao","year":"2022","unstructured":"Rao J, Qiu J, Ni M et al (2022) Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3\u2013mediated rhoa\/rock pathway in the ischemic liver. Hepatology 75:1429\u20131445. https:\/\/doi.org\/10.1002\/hep.32184","journal-title":"Hepatology"},{"key":"10872_CR28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1746-1596-8-110","volume":"8","author":"Z Guan","year":"2013","unstructured":"Guan Z, Zhang J, Song S, Dai D (2013) Promoter methylation and expression of TIMP3 gene in gastric cancer. Diagn Pathol 8:110. https:\/\/doi.org\/10.1186\/1746-1596-8-110","journal-title":"Diagn Pathol"},{"key":"10872_CR29","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/his.12047","volume":"62","author":"L Catasus","year":"2013","unstructured":"Catasus L, Pons C, Mu\u2009~\u2009Noz J et al (2013) Promoter hypermethylation contributes to TIMP3 down-regulation in high stage endometrioid endometrial carcinomas. Histopathology 62:632\u2013641. https:\/\/doi.org\/10.1111\/his.12047","journal-title":"Histopathology"},{"key":"10872_CR30","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.4161\/epi.22333","volume":"7","author":"T Shinojima","year":"2012","unstructured":"Shinojima T, Yu Q, Huang SK et al (2012) Heterogeneous epigenetic regulation of TIMP3 in prostate cancer. Epigenetics 7:1279\u20131289. https:\/\/doi.org\/10.4161\/epi.22333","journal-title":"Epigenetics"},{"issue":"7","key":"10872_CR31","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/mc.23003","volume":"58","author":"G Deb","year":"2019","unstructured":"Deb G, Shankar E, Thakur VS et al (2019) Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes. Mol Carcinog 58(7):1194\u20131207. https:\/\/doi.org\/10.1002\/mc.23003","journal-title":"Mol Carcinog"},{"issue":"4","key":"10872_CR32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s12032-013-0713-6","volume":"30","author":"C Xu","year":"2013","unstructured":"Xu C, Hou Z, Zhan P et al (2013) EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung cancer. Med Oncol 30(4):713. https:\/\/doi.org\/10.1007\/s12032-013-0713-6","journal-title":"Med Oncol"},{"key":"10872_CR33","doi-asserted-by":"publisher","first-page":"114253","DOI":"10.1016\/j.yexcr.2024.114253","volume":"442","author":"D Jia","year":"2024","unstructured":"Jia D, Ping W, Wang M et al (2024) SIRT1 mediates the inflammatory response of macrophages and regulates the TIMP3\/ADAM17 pathway in atherosclerosis. Exp Cell Res 442:114253. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114253","journal-title":"Exp Cell Res"},{"key":"10872_CR34","doi-asserted-by":"publisher","first-page":"27959","DOI":"10.18632\/oncotarget.8563","volume":"7","author":"L Kong","year":"2016","unstructured":"Kong L, Zhang P, Li W et al (2016) KDM1A promotes tumor cell invasion by Silencing TIMP3 in non-small cell lung cancer cells. Oncotarget 7:27959\u201327974. https:\/\/doi.org\/10.18632\/oncotarget.8563","journal-title":"Oncotarget"},{"key":"10872_CR35","doi-asserted-by":"publisher","first-page":"30393","DOI":"10.1371\/journal.pone.0030393","volume":"7","author":"YJ Shin","year":"2012","unstructured":"Shin YJ, Kim J-H (2012) The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells. PLoS ONE 7:30393. https:\/\/doi.org\/10.1371\/journal.pone.0030393","journal-title":"PLoS ONE"},{"issue":"6","key":"10872_CR36","doi-asserted-by":"publisher","first-page":"e202201765","DOI":"10.26508\/lsa.202201765","volume":"6","author":"H Jiang","year":"2023","unstructured":"Jiang H, Bai L, Song S et al (2023) EZH2 controls epicardial cell migration during heart development. Life Sci Alliance 6(6):e202201765. https:\/\/doi.org\/10.26508\/lsa.202201765","journal-title":"Life Sci Alliance"},{"key":"10872_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00048.2003.-Intimal","volume":"85","author":"AC Newby","year":"2005","unstructured":"Newby AC (2005) Dual role of matrix metalloproteinases (Matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85:1\u201331. https:\/\/doi.org\/10.1152\/physrev.00048.2003.-Intimal","journal-title":"Physiol Rev"},{"key":"10872_CR38","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms21249739","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C et al (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci 21:9739. https:\/\/doi.org\/10.3390\/ijms21249739","journal-title":"Int J Mol Sci"},{"key":"10872_CR39","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nature11262","volume":"488","author":"L Kruidenier","year":"2012","unstructured":"Kruidenier L, Chung C, Cheng Z et al (2012) A selective Jumonji H3K27 demethylase inhibitor modulates the Proinflammatory macrophage response. Nature 488:404\u2013408. https:\/\/doi.org\/10.1038\/nature11262","journal-title":"Nature"},{"key":"10872_CR40","doi-asserted-by":"publisher","first-page":"4107","DOI":"10.1096\/fj.201902200RR","volume":"34","author":"M Huang","year":"2020","unstructured":"Huang M, Wang Q, Long F et al (2020) Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice. FASEB J 34:4107\u20134119. https:\/\/doi.org\/10.1096\/fj.201902200RR","journal-title":"FASEB J"},{"issue":"1","key":"10872_CR41","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1038\/s41598-017-06914-5","volume":"7","author":"A Das","year":"2017","unstructured":"Das A, Arifuzzaman S, Yoon T et al (2017) RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective Jumonji H3K27 demethylase inhibitor. Sci Rep 7(1):6554. https:\/\/doi.org\/10.1038\/s41598-017-06914-5","journal-title":"Sci Rep"},{"key":"10872_CR42","doi-asserted-by":"publisher","unstructured":"Chen X, Barozzi I, Termanini A et al (2012) Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci 109. https:\/\/doi.org\/10.1073\/pnas.1121131109","DOI":"10.1073\/pnas.1121131109"},{"key":"10872_CR43","doi-asserted-by":"publisher","first-page":"30358","DOI":"10.1074\/jbc.M401359200","volume":"279","author":"L Klampfer","year":"2004","unstructured":"Klampfer L, Huang J, Swaby L-A, Augenlicht L (2004) Requirement of histone deacetylase activity for signaling by STAT1. J Biol Chem 279:30358\u201330368. https:\/\/doi.org\/10.1074\/jbc.M401359200","journal-title":"J Biol Chem"},{"key":"10872_CR44","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/rheumatology\/kev022","volume":"54","author":"MD Cantley","year":"2015","unstructured":"Cantley MD, Fairlie DP, Bartold PM et al (2015) Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology 54:1713\u20131723. https:\/\/doi.org\/10.1093\/rheumatology\/kev022","journal-title":"Rheumatology"},{"key":"10872_CR45","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.neuroscience.2010.04.074","volume":"169","author":"ZY Zhang","year":"2010","unstructured":"Zhang ZY, Zhang Z, Schluesener HJ (2010) MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis. Neuroscience 169:370\u2013377. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.04.074","journal-title":"Neuroscience"},{"key":"10872_CR46","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1002\/acn3.51200","volume":"7","author":"B Zierfuss","year":"2020","unstructured":"Zierfuss B, Weinhofer I, Buda A et al (2020) Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS-275. Ann Clin Transl Neurol 7:2161\u20132177. https:\/\/doi.org\/10.1002\/acn3.51200","journal-title":"Ann Clin Transl Neurol"},{"key":"10872_CR47","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1189\/jlb.0509363","volume":"87","author":"MA Halili","year":"2010","unstructured":"Halili MA, Andrews MR, Labzin LI et al (2010) Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. J Leukoc Biol 87:1103\u20131114. https:\/\/doi.org\/10.1189\/jlb.0509363","journal-title":"J Leukoc Biol"},{"issue":"8","key":"10872_CR48","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1111\/j.1476-5381.2011.01298.x","volume":"163","author":"B Reel","year":"2011","unstructured":"Reel B, Sala-Newby GB, Huang W-C, Newby AC (2011) Diverse patterns of cyclooxygenase-independent metalloproteinase gene regulation in human monocytes. Br J Pharmacol 163(8):1679\u20131690. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01298.x","journal-title":"Br J Pharmacol"},{"key":"10872_CR49","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.4049\/jimmunol.175.6.3637","volume":"175","author":"X Hu","year":"2005","unstructured":"Hu X, Park-Min K-H, Ho HH, Ivashkiv LB (2005) IFN-\u03b3-Primed macrophages exhibit increased CCR2-Dependent migration and altered IFN-\u03b3 responses mediated by Stat1. J Immunol 175:3637\u20133647. https:\/\/doi.org\/10.4049\/jimmunol.175.6.3637","journal-title":"J Immunol"},{"key":"10872_CR50","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41392-024-02039-0","volume":"9","author":"W Dai","year":"2024","unstructured":"Dai W, Qiao X, Fang Y et al (2024) Epigenetics-targeted drugs: current paradigms and future challenges. Signal Transduct Target Ther 9:332. https:\/\/doi.org\/10.1038\/s41392-024-02039-0","journal-title":"Signal Transduct Target Ther"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10872-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10872-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10872-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:27:57Z","timestamp":1766896077000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10872-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10872"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10872-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"16 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained under National Research Ethics Service approval from Frenchay Research Ethics Committee reference 09\/H0107\/22 and South West 4 Research Ethics Committee reference 10\/HO102\/72, respectively. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This is not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"775"}}