{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:53:45Z","timestamp":1768481625914,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Higher Education Malaysia for Transdisciplinary Research Grant Scheme","award":["TRGS\/1\/2020\/USM\/02\/3\/3"],"award-info":[{"award-number":["TRGS\/1\/2020\/USM\/02\/3\/3"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10930-4","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:39:15Z","timestamp":1755596355000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["THICAPA modulates amyloid precursor protein processing and alleviates oxidative stress in fibroblasts derived from patients with Familial Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8715-0383","authenticated-orcid":false,"given":"Danesh","family":"Thangeswaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-7740","authenticated-orcid":false,"given":"Shaharum","family":"Shamsuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-600X","authenticated-orcid":false,"given":"Venugopal","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"10930_CR1","unstructured":"Organization WH, Dementia, World Health Organization. Accessed: Jan. 19, 2022. [Online]. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia"},{"key":"10930_CR2","doi-asserted-by":"publisher","unstructured":"Kamble SM, Patil KR, Upaganlawar AB (Jan. 2024) Etiology, pathogenesis of alzheimer\u2019s disease and amyloid beta hypothesis. Alzheimers Dis Adv Drug Deliv Strateg 1\u201311. https:\/\/doi.org\/10.1016\/B978-0-443-13205-6.00022-4","DOI":"10.1016\/B978-0-443-13205-6.00022-4"},{"key":"10930_CR3","doi-asserted-by":"publisher","unstructured":"Fazeli E et al (June 2024) A Familial missense variant in the alzheimer\u2019s disease gene SORL1 impairs its maturation and endosomal sorting. Acta Neuropathol (Berl) 147(1):20. https:\/\/doi.org\/10.1007\/s00401-023-02670-1","DOI":"10.1007\/s00401-023-02670-1"},{"key":"10930_CR4","doi-asserted-by":"publisher","first-page":"11469","DOI":"10.1039\/c9dt01951k","volume":"48","author":"TM Khan","year":"2019","unstructured":"Khan TM et al (2019) Rhodium(III) complexes with isoquinoline derivatives as potential anticancer agents:: in vitro and in vivo activity studies. Dalton Trans 48:11469\u201311479. https:\/\/doi.org\/10.1039\/c9dt01951k","journal-title":"Dalton Trans"},{"key":"10930_CR5","doi-asserted-by":"publisher","unstructured":"Shamir A et al Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease, Int. J. Mol. Sci. (2024) Vol 25 Page 963, vol. 25, no. 2, p. 963, Jan. 2024. https:\/\/doi.org\/10.3390\/IJMS25020963","DOI":"10.3390\/IJMS25020963"},{"issue":"14","key":"10930_CR6","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1080\/07391102.2020.1784796","volume":"39","author":"NR Jabir","year":"2021","unstructured":"Jabir NR, Shakil S, Tabrez S, Khan MS, Rehman MT, Ahmed BA (2021) In Silico screening of glycogen synthase kinase-3\u03b2 targeted ligands against acetylcholinesterase and its probable relevance to alzheimer\u2019s disease. J Biomol Struct Dyn 39(14):5083\u20135092","journal-title":"J Biomol Struct Dyn"},{"issue":"4","key":"10930_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s12640-013-9440-1","volume":"25","author":"MA Kuszczyk","year":"2014","unstructured":"Kuszczyk MA, Sadowski MJ, Antkiewicz-Michaluk L, Lazarewicz JW (2014) 1MeTIQ provides protection against A\u03b2-induced reduction of surface expression of synaptic proteins and inhibits H2O2-induced oxidative stress in primary hippocampal neurons. Neurotox Res 25(4):348\u2013357. https:\/\/doi.org\/10.1007\/s12640-013-9440-1","journal-title":"Neurotox Res"},{"key":"10930_CR8","doi-asserted-by":"publisher","unstructured":"H\u00e9nykov\u00e1 E et al (2022) Quantitative Determination of Endogenous Tetrahydroisoquinolines, Potential Parkinson\u2019s Disease Biomarkers, in Mammals, ACS Chem. Neurosci., vol. 13, no. 23, pp. 3230\u20133246, Dec. https:\/\/doi.org\/10.1021\/ACSCHEMNEURO.2C00516","DOI":"10.1021\/ACSCHEMNEURO.2C00516"},{"key":"10930_CR9","doi-asserted-by":"publisher","unstructured":"Singh YP et al (July 2020) Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of alzheimer\u2019s disease. Eur J Med Chem 198. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112257","DOI":"10.1016\/j.ejmech.2020.112257"},{"issue":"6","key":"10930_CR10","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1080\/00397911.2020.1861302","volume":"51","author":"NC Desai","year":"2021","unstructured":"Desai NC, Jadeja KA, Jadeja DJ, Khedkar VM, Jha PC (2021) Design, synthesis, antimicrobial evaluation, and molecular Docking study of some 4-thiazolidinone derivatives containing pyridine and Quinazoline moiety. Synth Commun 51(6):952\u2013963. https:\/\/doi.org\/10.1080\/00397911.2020.1861302","journal-title":"Synth Commun"},{"key":"10930_CR11","doi-asserted-by":"publisher","unstructured":"Tan FHP et al (2023) 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against A\u03b242-Induced Toxicity In Vitro and in an Alzheimer\u2019s Disease, J. Gerontol. Ser. A, vol. 78, no. 11, pp. 1944\u20131952, Oct. https:\/\/doi.org\/10.1093\/gerona\/glad169","DOI":"10.1093\/gerona\/glad169"},{"key":"10930_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-60761-744-0_2","volume":"670","author":"WB Stine","year":"2011","unstructured":"Stine WB, Jungbauer L, Yu C, Ladu MJ (2011) Preparing synthetic A\u03b2 in different aggregation States. Methods Mol Biol 670:13\u201332. https:\/\/doi.org\/10.1007\/978-1-60761-744-0_2","journal-title":"Methods Mol Biol"},{"issue":"5054","key":"10930_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/SCIENCE.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256(5054):184\u2013185. https:\/\/doi.org\/10.1126\/SCIENCE.1566067","journal-title":"Science"},{"key":"10930_CR14","doi-asserted-by":"publisher","unstructured":"Frost GR, Li YM (Dec. 2017) The role of astrocytes in amyloid production and alzheimer\u2019s disease. Open Biol 7(12). https:\/\/doi.org\/10.1098\/RSOB.170228","DOI":"10.1098\/RSOB.170228"},{"key":"10930_CR15","doi-asserted-by":"publisher","unstructured":"Stegemann S, Moreton C, Svanb\u00e4ck S, Box K, Motte G, Paudel A (Feb. 2023) Trends in oral small-molecule drug discovery and product development based on product launches before and after the rule of five. Drug Discov Today 28(2):103344. https:\/\/doi.org\/10.1016\/j.drudis.2022.103344","DOI":"10.1016\/j.drudis.2022.103344"},{"key":"10930_CR16","doi-asserted-by":"crossref","unstructured":"Stan D-M (2018) Investigating alterations in autophagy in alzheimer\u2019s disease using human brain tissue and skin-derived fibroblasts","DOI":"10.1016\/j.jalz.2018.06.894"},{"key":"10930_CR17","doi-asserted-by":"publisher","unstructured":"Lopez-Toledo G, Silva-Lucero MDC, Herrera-D\u00edaz J, Garc\u00eda DE, Arias-Monta\u00f1o JA, Cardenas-Aguayo MDC (July 2022) Patient-Derived fibroblasts with Presenilin-1 mutations, that model aspects of alzheimer\u2019s disease pathology, constitute a potential object for early diagnosis. Front Aging Neurosci 14. https:\/\/doi.org\/10.3389\/fnagi.2022.921573","DOI":"10.3389\/fnagi.2022.921573"},{"key":"10930_CR18","doi-asserted-by":"publisher","unstructured":"Hern\u00e1ndez-Sapi\u00e9ns MA, Reza-Zald\u00edvar EE, Cevallos RR, M\u00e1rquez-Aguirre AL, Gazarian K, Canales-Aguirre AA (June 2020) A Three-Dimensional alzheimer\u2019s disease cell culture model using iPSC-Derived neurons carrying A246E mutation in PSEN1. Front Cell Neurosci 14. https:\/\/doi.org\/10.3389\/fncel.2020.00151","DOI":"10.3389\/fncel.2020.00151"},{"key":"10930_CR19","doi-asserted-by":"publisher","unstructured":"Campbell JE, Cohall D (2017) Pharmacodynamics-A pharmacognosy perspective. in Pharmacognosy: fundamentals, applications and strategy. Elsevier Inc., pp 513\u2013525. doi: https:\/\/doi.org\/10.1016\/B978-0-12-802104-0.00026-3.","DOI":"10.1016\/B978-0-12-802104-0.00026-3"},{"key":"10930_CR20","doi-asserted-by":"publisher","unstructured":"Liu X, Pacwa A, Bresciani G, Swierczynska M, Dorecka M, Smedowski A (July 2024) Retinal primary cilia and their dysfunction in retinal neurodegenerative diseases: beyond ciliopathies. Mol Med 30(1):109. https:\/\/doi.org\/10.1186\/s10020-024-00875-y","DOI":"10.1186\/s10020-024-00875-y"},{"key":"10930_CR21","doi-asserted-by":"publisher","unstructured":"Peng C et al (Jan. 2022) Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol 914. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174461","DOI":"10.1016\/j.ejphar.2021.174461"},{"key":"10930_CR22","doi-asserted-by":"publisher","unstructured":"Li S, Stern AM (2022) Bioactive human Alzheimer brain soluble A\u03b2: pathophysiology and therapeutic opportunities, Mol. Psychiatry vol. 27, no. 8, pp. 3182\u20133191, Apr. 2022. https:\/\/doi.org\/10.1038\/s41380-022-01589-5","DOI":"10.1038\/s41380-022-01589-5"},{"key":"10930_CR23","doi-asserted-by":"publisher","unstructured":"Jeong H, Shin H, Hong S, Kim YS (Apr. 2022) Physiological roles of monomeric Amyloid-\u03b2 and implications for alzheimer\u2019s disease therapeutics. Exp Neurobiol 31(2):65. https:\/\/doi.org\/10.5607\/EN22004","DOI":"10.5607\/EN22004"},{"key":"10930_CR24","doi-asserted-by":"publisher","unstructured":"Salahuddin P, Fatima MT, Abdelhameed AS, Nusrat S, Khan RH (May 2016) Structure of amyloid oligomers and their mechanisms of toxicities: targeting amyloid oligomers using novel therapeutic approaches. Eur J Med Chem 114:41\u201358. https:\/\/doi.org\/10.1016\/j.ejmech.2016.02.065","DOI":"10.1016\/j.ejmech.2016.02.065"},{"key":"10930_CR25","doi-asserted-by":"publisher","unstructured":"Limbocker R et al (Jan. 2019) Trodusquemine enhances A\u03b242 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nat Commun 10(1):225. https:\/\/doi.org\/10.1038\/s41467-018-07699-5","DOI":"10.1038\/s41467-018-07699-5"},{"key":"10930_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200096","author":"X Lu","year":"2022","unstructured":"Lu X et al (2022) Discovery of Tryptophan-tetrahydroisoquinoline derivatives as multifunctional agents for treatment of alzheimer\u2019s disease. Chin J Chem. https:\/\/doi.org\/10.1002\/cjoc.202200096","journal-title":"Chin J Chem"},{"key":"10930_CR27","doi-asserted-by":"publisher","unstructured":"Li Q, Sun J, Ran Q, Liu Z, Chen J (May 2024) The protective effects of Chromofungin in oligomeric amyloid \u03b242 (A\u03b242)-induced toxicity in neurons in alzheimer\u2019s disease. Aging 16(10):9216\u20139227. https:\/\/doi.org\/10.18632\/aging.205865","DOI":"10.18632\/aging.205865"},{"key":"10930_CR28","doi-asserted-by":"publisher","unstructured":"il Choi S, Lee B, Woo JH, Jeong JB, Jun I, Kim EK (May 2019) APP processing and metabolism in corneal fibroblasts and epithelium as a potential biomarker for alzheimer\u2019s disease. Exp Eye Res 182:167\u2013174. https:\/\/doi.org\/10.1016\/J.EXER.2019.03.012","DOI":"10.1016\/J.EXER.2019.03.012"},{"key":"10930_CR29","doi-asserted-by":"publisher","unstructured":"Sato K, Takayama KI, Hashimoto M, Inoue S (2021) Transcriptional and Post-Transcriptional regulations of Amyloid-\u03b2 precursor protein (APP) mRNA. Front Aging 2. https:\/\/doi.org\/10.3389\/fragi.2021.721579","DOI":"10.3389\/fragi.2021.721579"},{"key":"10930_CR30","doi-asserted-by":"publisher","unstructured":"Haass C, Kaether C, Thinakaran G, Sisodia S (2012) Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2(5). https:\/\/doi.org\/10.1101\/cshperspect.a006270","DOI":"10.1101\/cshperspect.a006270"},{"key":"10930_CR31","doi-asserted-by":"publisher","unstructured":"Takasugi N, Komai M, Kaneshiro N, Ikeda A, Kamikubo Y, Uehara T (Jan. 2023) The pursuit of the \u2018inside\u2019 of the amyloid Hypothesis\u2014Is C99 a promising therapeutic target for alzheimer\u2019s disease?? Cells 2023 12(3):454. https:\/\/doi.org\/10.3390\/CELLS12030454","DOI":"10.3390\/CELLS12030454"},{"key":"10930_CR32","doi-asserted-by":"publisher","unstructured":"Suhaimi AMM, Kamarulzaman EE, Wahab HA, Kasihmuddin MSM (2024) In-silico approaches in designing new drug candidates (THICAPA and POET) for alzheimer\u2019s disease, Pharm. Educ., vol. 24, no. 6, Art. no. 6, Oct. https:\/\/doi.org\/10.46542\/pe.2024.246.3542","DOI":"10.46542\/pe.2024.246.3542"},{"key":"10930_CR33","doi-asserted-by":"publisher","unstructured":"Lammich S et al (May 2010) Expression of the Anti-amyloidogenic secretase ADAM10 is suppressed by its 5\u2032-Untranslated region. J Biol Chem 285:15753. https:\/\/doi.org\/10.1074\/JBC.M110.110742","DOI":"10.1074\/JBC.M110.110742"},{"issue":"2","key":"10930_CR34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3233\/JAD-170061","volume":"58","author":"XZ Yuan","year":"2017","unstructured":"Yuan XZ, Sun S, Tan CC, Yu JT, Tan L (2017) The role of ADAM10 in alzheimer\u2019s disease. J Alzheimers Dis 58(2):303\u2013322. https:\/\/doi.org\/10.3233\/JAD-170061","journal-title":"J Alzheimers Dis"},{"key":"10930_CR35","doi-asserted-by":"publisher","unstructured":"Musardo S, Marcello E (Dec. 2017) Synaptic dysfunction in alzheimer\u2019s disease: from the role of amyloid \u03b2-peptide to the \u03b1-secretase ADAM10. Eur J Pharmacol 817:30\u201337. https:\/\/doi.org\/10.1016\/J.EJPHAR.2017.06.018","DOI":"10.1016\/J.EJPHAR.2017.06.018"},{"key":"10930_CR36","doi-asserted-by":"publisher","unstructured":"Peters-Libeu C et al (Aug. 2015) SA\u03b2PP\u03b1 is a potent endogenous inhibitor of BACE1. J Alzheimers Dis 47(3):545\u2013555. https:\/\/doi.org\/10.3233\/JAD-150282","DOI":"10.3233\/JAD-150282"},{"key":"10930_CR37","doi-asserted-by":"publisher","unstructured":"Folch J et al (Jan. 2018) Una revisi\u00f3n de Los Avances En La terap\u00e9utica de La Enfermedad de alzheimer: estrategia Frente a La Prote\u00edna \u03b2-amiloide. Neurologia 33(1):35\u201346. https:\/\/doi.org\/10.1016\/j.nrl.2015.03.012","DOI":"10.1016\/j.nrl.2015.03.012"},{"key":"10930_CR38","doi-asserted-by":"publisher","unstructured":"Obregon D et al (Apr. 2012) Soluble amyloid precursor protein-\u03b1 modulates \u03b2-secretase activity and amyloid-\u03b2 generation. Nat Commun 3(1):777. https:\/\/doi.org\/10.1038\/ncomms1781","DOI":"10.1038\/ncomms1781"},{"key":"10930_CR39","doi-asserted-by":"publisher","unstructured":"Dehury B, Somavarapu AK, Kepp KP (Dec. 2020) A computer-simulated mechanism of Familial alzheimer\u2019s disease: mutations enhance thermal dynamics and favor looser substrate-binding to \u03b3-secretase. J Struct Biol 212(3):107648. https:\/\/doi.org\/10.1016\/J.JSB.2020.107648","DOI":"10.1016\/J.JSB.2020.107648"},{"key":"10930_CR40","doi-asserted-by":"publisher","unstructured":"Araki W et al (2022) Soluble APP-\u03b1 and APP-\u03b2 in cerebrospinal fluid as potential biomarkers for differential diagnosis of mild cognitive impairment, Aging Clin. Exp. Res., vol. 34, no. 2, pp. 341\u2013347, Feb. https:\/\/doi.org\/10.1007\/S40520-021-01935-7","DOI":"10.1007\/S40520-021-01935-7"},{"key":"10930_CR41","doi-asserted-by":"publisher","unstructured":"Aubert A, Mendoza-Ferri MG, Bramoulle A, St\u00fcder F, Colombo BM, Mendoza-Parra MA (2023) PSEN1 M146V and PSEN1 A246E mutations associated with alzheimer\u2019s disease impair proper microglia differentiation. BioRxiv 10. https:\/\/doi.org\/10.1101\/2023.10.08.561397","DOI":"10.1101\/2023.10.08.561397"},{"key":"10930_CR42","doi-asserted-by":"publisher","unstructured":"Zhou R, Yang G, Shi Y (Apr. 2020) Macromolecular complex in recognition and proteolysis of amyloid precursor protein in alzheimer\u2019s disease. Curr Opin Struct Biol 61:1\u20138. https:\/\/doi.org\/10.1016\/j.sbi.2019.09.004","DOI":"10.1016\/j.sbi.2019.09.004"},{"key":"10930_CR43","doi-asserted-by":"publisher","unstructured":"Liu P et al (2018) The isoquinoline alkaloid Dauricine targets multiple molecular pathways to ameliorate Alzheimer-like pathological changes in vitro. Oxid Med Cell Longev 2018. https:\/\/doi.org\/10.1155\/2018\/2025914","DOI":"10.1155\/2018\/2025914"},{"key":"10930_CR44","doi-asserted-by":"publisher","unstructured":"Chen C et al (2021). Dauricine attenuates spatial memory impairment and Alzheimer-like pathologies by enhancing mitochondrial function in a mouse model of Alzheimer's disease. Front Cell Dev Biol 8:624339. https:\/\/doi.org\/10.3389\/fcell.2020.624339","DOI":"10.3389\/fcell.2020.624339"},{"key":"10930_CR45","doi-asserted-by":"publisher","unstructured":"Xue JS et al (Sept. 2023) Dauricine alleviates cognitive impairment in alzheimer\u2019s disease mice induced by D-galactose and AlCl3 via the Ca2+\/CaM pathway. Toxicol Appl Pharmacol 474. https:\/\/doi.org\/10.1016\/j.taap.2023.116613","DOI":"10.1016\/j.taap.2023.116613"},{"issue":"15","key":"10930_CR46","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1002\/cjoc.202200096","volume":"40","author":"X Lu","year":"2022","unstructured":"Lu X et al (2022) Discovery of Tryptophan-tetrahydroisoquinoline derivatives as multifunctional agents for treatment of alzheimer\u2019s disease. Chin J Chem 40(15):1821\u20131830. https:\/\/doi.org\/10.1002\/cjoc.202200096","journal-title":"Chin J Chem"},{"key":"10930_CR47","doi-asserted-by":"publisher","unstructured":"Pritam P et al (Jan. 2022) Antioxidants in alzheimer\u2019s disease: current therapeutic significance and future prospects. Biology 11(2):212. https:\/\/doi.org\/10.3390\/biology11020212","DOI":"10.3390\/biology11020212"},{"key":"10930_CR48","doi-asserted-by":"publisher","unstructured":"de Almeida MP, Valle Pedroso R, Mantellatto Grigoli M, Vicente Silva T, Manzine PR, Cominetti MR (2023) ADAM10 as a biomarker for Alzheimer\u2019s disease: A systematic review, Rev. Neurol. (Paris), July https:\/\/doi.org\/10.1016\/j.neurol.2023.04.002","DOI":"10.1016\/j.neurol.2023.04.002"},{"key":"10930_CR49","doi-asserted-by":"publisher","unstructured":"Hata J et al (2019) Association Between Serum \u03b2-Alanine and Risk of Dementia: The Hisayama Study, Am. J. Epidemiol., vol. 188, no. 9, pp. 1637\u20131645, Sept. https:\/\/doi.org\/10.1093\/AJE\/KWZ116","DOI":"10.1093\/AJE\/KWZ116"},{"key":"10930_CR50","doi-asserted-by":"publisher","unstructured":"Solana-Manrique C, Sanz FJ, Mart\u00ednez-Carri\u00f3n G, Paricio N (Apr. 2022) Antioxidant and neuroprotective effects of carnosine: therapeutic implications in neurodegenerative diseases. Antioxid 2022 11(5):848. https:\/\/doi.org\/10.3390\/ANTIOX11050848","DOI":"10.3390\/ANTIOX11050848"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10930-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10930-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10930-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:26:56Z","timestamp":1766896016000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10930-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10930"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10930-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"835"}}