{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:53:16Z","timestamp":1771537996650,"version":"3.50.1"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274125"],"award-info":[{"award-number":["82274125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10964-8","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:57:40Z","timestamp":1759172260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential new drug sources for the treatment of Parkinson\u2019s disease: flavonoid O-glycosides"],"prefix":"10.1007","volume":"52","author":[{"given":"Yehao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runda","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningxia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"10964_CR1","volume":"2016","author":"L Xu","year":"2016","unstructured":"Xu L, Pu J (2016) Alpha-synuclein in Parkinson\u2019s disease: from pathogenetic dysfunction to potential clinical application. Parkinsons Dis 2016:2016:1720621","journal-title":"Parkinsons Dis"},{"issue":"1","key":"10964_CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/brain\/awad260","volume":"147","author":"A Chopra","year":"2024","unstructured":"Chopra A, Outeiro TF (2024) Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies. Brain 147(1):81\u201390","journal-title":"Brain"},{"issue":"2","key":"10964_CR3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/jamaneurol.2021.4736","volume":"79","author":"R Gray","year":"2022","unstructured":"Gray R, Patel S, Ives N et al (2022) Long-term effectiveness of adjuvant treatment with catechol-O-methyltransferase or monoamine oxidase B inhibitors compared with dopamine agonists among patients with Parkinson disease uncontrolled by Levodopa therapy: the PD MED randomized clinical trial. JAMA Neurol 79(2):131\u2013140","journal-title":"JAMA Neurol"},{"issue":"1618","key":"10964_CR4","first-page":"25","volume":"63","author":"Drugs for Parkinson\u2019s disease[J]","year":"2021","unstructured":"Drugs for Parkinson\u2019s disease[J] (2021) Med Lett Drugs Ther 63(1618):25\u201332","journal-title":"Med Lett Drugs Ther"},{"issue":"5","key":"10964_CR5","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1073\/pnas.1524387113","volume":"113","author":"R Marongiu","year":"2016","unstructured":"Marongiu R, Arango-Lievano M, Francardo V et al (2016) Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice. Proc Natl Acad Sci U S A 113(5):1423\u20131428","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10964_CR6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s12276-021-00646-3","volume":"53","author":"HU Cho","year":"2021","unstructured":"Cho HU, Kim S, Sim J et al (2021) Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis. Exp Mol Med 53(7):1148\u20131158","journal-title":"Exp Mol Med"},{"issue":"3","key":"10964_CR7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JPD-130186","volume":"3","author":"D Salat","year":"2013","unstructured":"Salat D, Tolosa E (2013) Levodopa in treating Parkinson\u2019s disease: current status and new developments. J Parkinsons Dis 3(3):255\u2013269","journal-title":"J Parkinsons Dis"},{"key":"10964_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050559","author":"H Yuan","year":"2016","unstructured":"Yuan H, Ma Q, Ye L et al (2016) The traditional medicine and modern medicine from natural products. Molecule 21(5):559 https:\/\/doi.org\/10.3390\/molecules21050559","journal-title":"Molecules"},{"key":"10964_CR9","doi-asserted-by":"crossref","unstructured":"Xie L, Deng Z, Zhang J et al (2022) Comparison of flavonoid O-Glycoside, C-Glycoside, and their aglycones on antioxidant capacity and metabolism during in vitro digestion and Vivo[J]. Foods 11(6):882","DOI":"10.3390\/foods11060882"},{"issue":"6","key":"10964_CR10","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1021\/acs.analchem.4c06133","volume":"97","author":"Y Wang","year":"2025","unstructured":"Wang Y, Zhu Z, Deng L et al (2025) Multiscale synergy networks offer insights into disease and comorbidity mechanisms. Anal Chem 97(6):3633\u20133642","journal-title":"Anal Chem"},{"key":"10964_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12080721","author":"H Idborg","year":"2022","unstructured":"Idborg H, Pawelzik SC (2022) Prostanoid metabolites as biomarkers in human disease. Metabolites12(8):721. https:\/\/doi.org\/10.3390\/metabo12080721","journal-title":"Metabolites"},{"key":"10964_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111032","author":"F Zhao","year":"2022","unstructured":"Zhao F, Ma Y, Yin J et al (2022) Analysis of galangin and its in vitro\/in vivo metabolites via ultra-high-performance liquid chromatography\/quadrupole time-of-flight mass spectrometry. Metabolites. https:\/\/doi.org\/10.3390\/metabo12111032","journal-title":"Metabolites"},{"issue":"9","key":"10964_CR13","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1074\/mcp.M116.060665","volume":"15","author":"JC Davis","year":"2016","unstructured":"Davis JC, Totten SM, Huang JO et al (2016) Identification of oligosaccharides in feces of breast-fed infants and their correlation with the gut microbial community. Mol Cell Proteomics 15(9):2987\u20133002","journal-title":"Mol Cell Proteomics"},{"key":"10964_CR14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jchromb.2012.05.009","volume":"899","author":"J Vacek","year":"2012","unstructured":"Vacek J, Papouskova B, Kosina P et al (2012) Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci 899:109\u2013115","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"1","key":"10964_CR15","volume":"23","author":"T Pei","year":"2022","unstructured":"Pei T, Yan M, Li T et al (2022) Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis. BMC Genomics 23(1):169","journal-title":"BMC Genomics"},{"issue":"11","key":"10964_CR16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1080\/00498254.2019.1567956","volume":"50","author":"Q Jiao","year":"2020","unstructured":"Jiao Q, Xu L, Jiang L et al (2020) Metabolism study of Hesperetin and hesperidin in rats by UHPLC-LTQ-Orbitrap MS (n). Xenobiotica 50(11):1311\u20131322","journal-title":"Xenobiotica"},{"issue":"7","key":"10964_CR17","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bcp.2011.01.004","volume":"81","author":"CC Wong","year":"2011","unstructured":"Wong CC, Botting NP, Orfila C et al (2011) Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of Adefovir mediated by organic anion transporter 1 (OAT1\/SLC22A6). Biochem Pharmacol 81(7):942\u2013949","journal-title":"Biochem Pharmacol"},{"key":"10964_CR18","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00248","volume":"11","author":"EL Gorenberg","year":"2017","unstructured":"Gorenberg EL, Chandra SS (2017) The role of co-chaperones in synaptic proteostasis and neurodegenerative disease. Front Neurosci 11:248","journal-title":"Front Neurosci"},{"issue":"9","key":"10964_CR19","doi-asserted-by":"crossref","first-page":"183314","DOI":"10.1016\/j.bbamem.2020.183314","volume":"1862","author":"R Adao","year":"2020","unstructured":"Adao R, Cruz PF, Vaz DC et al (2020) DIBMA nanodiscs keep alpha-synuclein folded[J]. Biochim Biophys Acta Biomembr 1862(9):183314","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"10","key":"10964_CR20","volume":"17","author":"SJ Park","year":"2021","unstructured":"Park SJ, Jin U, Park SM (2021) Interaction between coxsackievirus B3 infection and alpha-synuclein in models of parkinson\u2019s disease. PLoS Pathog 17(10):e1010018","journal-title":"PLoS Pathog"},{"key":"10964_CR21","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113315","volume":"330","author":"A Haque","year":"2020","unstructured":"Haque A, Samantaray S, Knaryan VH et al (2020) Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson\u2019s disease. Exp Neurol 330:113315","journal-title":"Exp Neurol"},{"key":"10964_CR22","doi-asserted-by":"crossref","first-page":"112676","DOI":"10.1016\/j.intimp.2024.112676","volume":"139","author":"K Li","year":"2024","unstructured":"Li K, Ling H, Huang W et al (2024) Single-cell RNA-sequencing analysis reveals alpha-syn-induced astrocyte-neuron crosstalk-mediated neurotoxicity[J]. Int Immunopharmacol 139:112676","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"10964_CR23","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-2092-1","volume":"10","author":"M Vicario","year":"2019","unstructured":"Vicario M, Cieri D, Vallese F et al (2019) A split-GFP tool reveals differences in the sub-mitochondrial distribution of Wt and mutant alpha-synuclein. Cell Death Dis 10(11):857","journal-title":"Cell Death Dis"},{"issue":"5","key":"10964_CR24","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1002\/fsn3.3050","volume":"11","author":"C Xiong","year":"2023","unstructured":"Xiong C, Zhu Y, Luo Q et al (2023) Neuroprotective effects of a novel peptide from lignosus rhinocerotis against 6-hydroxydopamine-induced apoptosis in PC12 cells by inhibiting NF-kappaB activation[J]. Food Sci Nutr 11(5):2152\u20132165","journal-title":"Food Sci Nutr"},{"key":"10964_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28247988","author":"S Kang","year":"2023","unstructured":"Kang S, Noh Y, Oh SJ et al (2023) Neuroprotective effects of aldehyde-reducing composition in an LPS-induced neuroinflammation model of Parkinson\u2019s disease. Molecules 28(24):7988. https:\/\/doi.org\/10.3390\/molecules28247988","journal-title":"Molecules"},{"key":"10964_CR26","doi-asserted-by":"crossref","unstructured":"Utpal BK, Al AM, Zehravi M et al (2025) Alkaloids as neuroprotectors: targeting signaling pathways in neurodegenerative diseases[J]. Mol Cell Biochem","DOI":"10.1007\/s11010-025-05258-3"},{"issue":"3","key":"10964_CR27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12640-023-00636-5","volume":"41","author":"X Lai","year":"2023","unstructured":"Lai X, Zhang Y, Wu J et al (2023) Rutin attenuates oxidative stress via PHB2-mediated mitophagy in MPP(+)-induced SH-SY5Y cells. Neurotox Res 41(3):242\u2013255","journal-title":"Neurotox Res"},{"key":"10964_CR28","doi-asserted-by":"crossref","unstructured":"Faysal M, Al AM, Zehravi M et al (2025) Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus[J]. Naunyn Schmiedebergs Arch Pharmacol","DOI":"10.1007\/s00210-025-03888-4"},{"key":"10964_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500170","author":"M Begh","year":"2025","unstructured":"Begh M, Amin MA, Shatu MM et al (2025) Unraveling berberine\u2019s molecular mechanisms in neuroprotection against neurodegeneration. Chem Biodivers 22(8):e202500170. https:\/\/doi.org\/10.1002\/cbdv.202500170","journal-title":"Chem Biodivers"},{"key":"10964_CR30","doi-asserted-by":"crossref","first-page":"111218","DOI":"10.1016\/j.cbi.2024.111218","volume":"402","author":"FZ Mokhfi","year":"2024","unstructured":"Mokhfi FZ, Al AM, Zehravi M et al (2024) Alkaloid-based modulators of the PI3K\/Akt\/mTOR pathway for cancer therapy: Understandings from a Pharmacological point of view[J]. Chem Biol Interact 402:111218","journal-title":"Chem Biol Interact"},{"key":"10964_CR31","doi-asserted-by":"crossref","unstructured":"Durgawale TP, Rajashakar V, Gupta JK et al (2025) Phytochemical-Based drug discovery for breast cancer: combining virtual screening and molecular dynamics to identify novel Therapeutics[J]. Chem Biodivers 22(6):e202402864","DOI":"10.1002\/cbdv.202402864"},{"issue":"1","key":"10964_CR32","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1080\/21655979.2021.1960767","volume":"12","author":"C Li","year":"2021","unstructured":"Li C, Zhang Y, Liu R et al (2021) Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway. Bioengineered 12(1):4868\u20134877","journal-title":"Bioengineered"},{"issue":"6","key":"10964_CR33","first-page":"4913","volume":"18","author":"H Chen","year":"2018","unstructured":"Chen H, Xu J, Lv Y et al (2018) Proanthocyanidins exert a neuroprotective effect via ROS\/JNK signaling in MPTP-induced parkinson\u2019s disease models in vitro and in vivo[J]. Mol Med Rep 18(6):4913\u20134921","journal-title":"Mol Med Rep"},{"issue":"1","key":"10964_CR34","volume":"15","author":"J Kim","year":"2024","unstructured":"Kim J, Yu YS, Choi Y et al (2024) USF2 and TFEB compete in regulating lysosomal and autophagy genes. Nat Commun 15(1):8334","journal-title":"Nat Commun"},{"key":"10964_CR35","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5253","author":"Z Ma","year":"2023","unstructured":"Ma Z, Liang H, Hu B et al (2023) Autophagyregulating miRNAs: novel therapeutic targets for Parkinson\u2019s disease (Review). Int J Mol Med 51(6):50. https:\/\/doi.org\/10.3892\/ijmm.2023.5253","journal-title":"Int J Mol Med"},{"issue":"1","key":"10964_CR36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/15548627.2018.1509818","volume":"15","author":"H Li","year":"2019","unstructured":"Li H, Ham A, Ma TC et al (2019) Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. Autophagy 15(1):113\u2013130","journal-title":"Autophagy"},{"issue":"2","key":"10964_CR37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11011-020-00641-z","volume":"36","author":"AB Enogieru","year":"2021","unstructured":"Enogieru AB, Haylett W, Hiss DC et al (2021) Regulation of AKT\/AMPK signaling, autophagy, and mitigation of apoptosis in rutin-pretreated SH-SY5Y cells exposed to MPP+. Metab Brain Dis 36(2):315\u2013326","journal-title":"Metab Brain Dis"},{"issue":"4","key":"10964_CR38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4103\/1673-5374.205084","volume":"12","author":"TB Sampaio","year":"2017","unstructured":"Sampaio TB, Savall AS, Gutierrez M et al (2017) Neurotrophic factors in Alzheimer\u2019s and Parkinson\u2019s diseases: implications for pathogenesis and therapy. Neural Regen Res 12(4):549\u2013557","journal-title":"Neural Regen Res"},{"key":"10964_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/biology12101360","author":"M Ayon-Olivas","year":"2023","unstructured":"Ayon-Olivas M, Wolf D, Andreska T et al (2023) Dopaminergic input regulates the sensitivity of indirect pathway striatal spiny neurons to Brain-derived neurotrophic factor. Biology (Basel) 12(10):1360. https:\/\/doi.org\/10.3390\/biology12101360","journal-title":"Biology (Basel)"},{"issue":"5","key":"10964_CR40","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1139\/bcb-2017-0209","volume":"96","author":"H Liu","year":"2018","unstructured":"Liu H, Zhong L, Zhang Y et al (2018) Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling. Biochem Cell Biol 96(5):672\u2013681","journal-title":"Biochem Cell Biol"},{"issue":"1","key":"10964_CR41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2225-4110.106548","volume":"3","author":"SH Lin","year":"2013","unstructured":"Lin SH, Chang HC, Chen PJ et al (2013) The Antidepressant-like effect of ethanol extract of daylily flowers (Jin Zhen Hua) in Rats[J]. J Tradit Complement Med 3(1):53\u201361","journal-title":"J Tradit Complement Med"},{"issue":"1","key":"10964_CR42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1515\/hsz-2021-0259","volume":"403","author":"A Christmann","year":"2022","unstructured":"Christmann A, Gries M, Scholz P et al (2022) The antioxidant Rutin counteracts the pathological impact of alpha-synuclein on the enteric nervous system in vitro[J]. Biol Chem 403(1):103\u2013122","journal-title":"Biol Chem"},{"issue":"12","key":"10964_CR43","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.4103\/NRR.NRR-D-24-00994","volume":"20","author":"SJ Park","year":"2025","unstructured":"Park SJ, Kim KW, Lee EJ (2025) Gut-brain axis and environmental factors in Parkinson\u2019s disease: the bidirectional link between disease onset and progression. Neural Regen Res 20(12):3416\u20133429","journal-title":"Neural Regen Res"},{"issue":"3","key":"10964_CR44","first-page":"224","volume":"41","author":"FM De Araujo","year":"2023","unstructured":"De Araujo FM, Frota AF, de Jesus LB et al (2023) Protective effects of flavonoid Rutin against aminochrome Neurotoxicity[J]. Neurotox Res 41(3):224\u2013241","journal-title":"Neurotox Res"},{"issue":"7","key":"10964_CR45","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/1028415X.2023.2253026","volume":"27","author":"MA Abdel-Kawy","year":"2024","unstructured":"Abdel-Kawy MA, Aboulhoda BE, Michel CG et al (2024) Ameliorating effect of citrus trifoliata L. fruits extracts on motor incoordination, neurodegeneration, and oxidative stress in parkinson\u2019s disease model. Nutr Neurosci 27(7):770\u2013782","journal-title":"Nutr Neurosci"},{"key":"10964_CR46","doi-asserted-by":"crossref","unstructured":"Hajialyani M, Hosein FM, Echeverria J et al (2019) Hesperidin as a neuroprotective agent: A review of animal and clinical Evidence[J]. Molecules, 24(3)","DOI":"10.3390\/molecules24030648"},{"key":"10964_CR47","volume":"99","author":"J Wu","year":"2021","unstructured":"Wu J, Xu X, Zheng L et al (2021) Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in parkinson\u2019s disease models. Int Immunopharmacol 99:108025","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10964_CR48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00210-024-03342-x","volume":"398","author":"M Begh","year":"2025","unstructured":"Begh M, Khan J, Al AM et al (2025) Monoterpenoid synergy: a new frontier in biological applications[J]. Naunyn Schmiedebergs Arch Pharmacol 398(1):103\u2013124","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"9","key":"10964_CR49","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1007\/s12035-023-03370-3","volume":"60","author":"X Liu","year":"2023","unstructured":"Liu X, Yang L, Zhang G et al (2023) Neuroprotective effects of phenolic antioxidant tert-butyl hydroquinone (TBHQ) in brain diseases. Mol Neurobiol 60(9):4909\u20134923","journal-title":"Mol Neurobiol"},{"issue":"2","key":"10964_CR50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.12965\/jer.2142188.094","volume":"17","author":"SH Kim","year":"2021","unstructured":"Kim SH, Ko YJ, Baek SS (2021) Resistance exercise improves short-term memory through inactivation of NF-kappaB pathway in mice with parkinson\u2019s disease[J]. J Exerc Rehabil 17(2):81\u201387","journal-title":"J Exerc Rehabil"},{"issue":"7","key":"10964_CR51","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1007\/s12035-020-01940-3","volume":"57","author":"MS Antunes","year":"2020","unstructured":"Antunes MS, Cattelan SL, Ladd F et al (2020) Hesperidin ameliorates Anxiety-Depressive-Like behavior in 6-OHDA model of parkinson\u2019s disease by regulating striatal cytokine and neurotrophic factors levels and dopaminergic innervation loss in the striatum of Mice[J]. Mol Neurobiol 57(7):3027\u20133041","journal-title":"Mol Neurobiol"},{"key":"10964_CR52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cbi.2017.11.018","volume":"279","author":"MR Poetini","year":"2018","unstructured":"Poetini MR, Araujo SM, Trindade DPM et al (2018) Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in the drosophila melanogaster model of parkinson\u2019s disease[J]. Chem Biol Interact 279:177\u2013186","journal-title":"Chem Biol Interact"},{"issue":"5","key":"10964_CR53","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","volume":"25","author":"T Kamath","year":"2022","unstructured":"Kamath T, Abdulraouf A, Burris SJ et al (2022) Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in parkinson\u2019s disease[J]. Nat Neurosci 25(5):588\u2013595","journal-title":"Nat Neurosci"},{"issue":"1","key":"10964_CR54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11011-020-00618-y","volume":"36","author":"MS Antunes","year":"2021","unstructured":"Antunes MS, Ladd F, Ladd A et al (2021) Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metab Brain Dis 36(1):153\u2013167","journal-title":"Metab Brain Dis"},{"issue":"Suppl 1","key":"10964_CR55","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1016\/S1353-8020(13)70036-1","volume":"20","author":"JP de Munter","year":"2014","unstructured":"de Munter JP, Melamed E, Wolters E (2014) Stem cell grafting in parkinsonism\u2013why, how and when[J]. Parkinsonism Relat Disord 20(Suppl 1):S150\u2013S153","journal-title":"Parkinsonism Relat Disord"},{"issue":"5","key":"10964_CR56","first-page":"1489","volume":"36","author":"Z Wenbo","year":"2023","unstructured":"Wenbo Z, Zhigang M, Jiren Z et al (2023) Antinociceptive effects of carbidopa-levodopa on normal rats and parkinson\u2019s disease mice[J]. Pak J Pharm Sci 36(5):1489\u20131495","journal-title":"Pak J Pharm Sci"},{"key":"10964_CR57","volume":"8","author":"G Santos","year":"2016","unstructured":"Santos G, Giraldez-Alvarez LD, Avila-Rodriguez M et al (2016) SUR1 receptor interaction with hesperidin and linarin predicts possible mechanisms of action of Valeriana officinalis in Parkinson. Front Aging Neurosci 8:97","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"10964_CR58","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s00210-023-02915-6","volume":"397","author":"MV Suryawanshi","year":"2024","unstructured":"Suryawanshi MV, Gujarathi PP, Mulla T et al (2024) Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases. Naunyn Schmiedebergs Arch Pharmacol 397(6):3803\u20133818","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10964_CR59","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2147\/JIR.S362006","volume":"15","author":"H Jung","year":"2022","unstructured":"Jung H, Lee H, Kim D et al (2022) Differential regional vulnerability of the brain to mild neuroinflammation induced by systemic LPS treatment in Mice[J]. J Inflamm Res 15:3053\u20133063","journal-title":"J Inflamm Res"},{"issue":"17","key":"10964_CR60","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1111\/bph.15502","volume":"178","author":"X Li","year":"2021","unstructured":"Li X, Wu X, Li N et al (2021) Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: likely role of Na(v) 1.6 inhibition in microglia. Br J Pharmacol 178(17):3553\u20133569","journal-title":"Br J Pharmacol"},{"key":"10964_CR61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.intimp.2017.06.004","volume":"50","author":"HH Fan","year":"2017","unstructured":"Fan HH, Zhu LB, Li T et al (2017) Hyperoside inhibits lipopolysaccharide-induced inflammatory responses in microglial cells via p38 and NF-kappaB pathways[J]. Int Immunopharmacol 50:14\u201321","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10964_CR62","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s11064-016-2117-4","volume":"42","author":"L Luo","year":"2017","unstructured":"Luo L, Chen J, Su D et al (2017) L-F001, a multifunction ROCK inhibitor prevents 6-OHDA induced cell death through activating Akt\/GSK-3beta and Nrf2\/HO-1 signaling pathway in PC12 cells and attenuates MPTP-induced dopamine neuron toxicity in mice. Neurochem Res 42(2):615\u2013624","journal-title":"Neurochem Res"},{"key":"10964_CR63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2017.02.021","volume":"1662","author":"T Baluchnejadmojarad","year":"2017","unstructured":"Baluchnejadmojarad T, Rabiee N, Zabihnejad S et al (2017) Ellagic acid exerts a protective effect in an intrastriatal 6-hydroxydopamine rat model of parkinson\u2019s disease: possible involvement of ERbeta\/Nrf2\/HO-1 signaling[J]. Brain Res 1662:23\u201330","journal-title":"Brain Res"},{"issue":"12","key":"10964_CR64","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s11064-021-03404-z","volume":"46","author":"H Fan","year":"2021","unstructured":"Fan H, Li Y, Sun M et al (2021) Hyperoside reduces rotenone-induced neuronal injury by suppressing autophagy. Neurochem Res 46(12):3149\u20133158","journal-title":"Neurochem Res"},{"key":"10964_CR65","doi-asserted-by":"crossref","unstructured":"Benitez-Castaneda A, Anaya-Martinez V, Espadas-Alvarez AJ et al \uff082024\uff09 Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson\u2019s Disease[J]. Parkinson\u2019s Dis2024:3885451","DOI":"10.1155\/2024\/3885451"},{"issue":"3","key":"10964_CR66","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s11011-022-01153-8","volume":"38","author":"XJ Xu","year":"2023","unstructured":"Xu XJ, Pan T, Fan HJ et al (2023) Neuroprotective effect of Hyperoside in MPP(+)\/MPTP -induced dopaminergic neurodegeneration[J]. Metab Brain Dis 38(3):1035\u20131050","journal-title":"Metab Brain Dis"},{"key":"10964_CR67","doi-asserted-by":"crossref","first-page":"111202","DOI":"10.1016\/j.brainresbull.2025.111202","volume":"221","author":"Q Fu","year":"2025","unstructured":"Fu Q, Yu Q, Luo H et al (2025) Protective effects of Wogonin in treating central nervous system and degenerative diseases[J]. Brain Res Bull 221:111202","journal-title":"Brain Res Bull"},{"issue":"1","key":"10964_CR68","volume":"11","author":"L Si","year":"2025","unstructured":"Si L, An Y, Zhou J et al (2025) Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms. Heliyon 11(1):e41002","journal-title":"Heliyon"},{"key":"10964_CR69","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jep.2014.08.031","volume":"156","author":"M Li","year":"2014","unstructured":"Li M, Shi A, Pang H et al (2014) Safety, tolerability, and pharmacokinetics of a single ascending dose of Baicalein chewable tablets in healthy subjects. J Ethnopharmacol 156:210\u2013215","journal-title":"J Ethnopharmacol"},{"key":"10964_CR70","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110820","volume":"387","author":"J Huang","year":"2024","unstructured":"Huang J, Zhang X, Yang X et al (2024) Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of parkinson\u2019s disease. Chem Biol Interact 387:110820","journal-title":"Chem Biol Interact"},{"issue":"12","key":"10964_CR71","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3263","volume":"9","author":"Q Tang","year":"2019","unstructured":"Tang Q, Su YW, Xian CJ (2019) Determining oxidative damage by lipid peroxidation assay in rat serum. Bio-protocol 9(12):e3263","journal-title":"Bio-protocol"},{"key":"10964_CR72","doi-asserted-by":"crossref","unstructured":"Lei K, Shen Y, He Y et al (2020) Baicalin Represses C\/EBPbeta via Its Antioxidative Effect on Parkinson\u2019s Disease[J]. Oxid Med Cell Longev, 2020:8951907","DOI":"10.1155\/2020\/8951907"},{"issue":"27","key":"10964_CR73","first-page":"2092","volume":"7","author":"P Xiong","year":"2012","unstructured":"Xiong P, Chen X, Guo C et al (2012) Baicalin and deferoxamine alleviate iron accumulation in different brain regions of Parkinson\u2019s disease rats. Neural Regen Res 7(27):2092\u20132098","journal-title":"Neural Regen Res"},{"key":"10964_CR74","doi-asserted-by":"crossref","unstructured":"Prevost ED, Ward LA, Alas D et al (2025) Untangling dopamine and glutamate in the ventral tegmental area[J]. bioRxiv","DOI":"10.1101\/2025.02.25.640201"},{"key":"10964_CR75","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.2147\/NDT.S165931","volume":"15","author":"L Tu","year":"2019","unstructured":"Tu L, Wu ZY, Yang XL et al (2019) Neuroprotective effect and mechanism of Baicalin on parkinson\u2019s disease model induced by 6-OHDA[J]. Neuropsychiatr Dis Treat 15:3615\u20133625","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10964_CR76","volume":"269","author":"M Zhang","year":"2021","unstructured":"Zhang M, Zhan A, Ye Y et al (2021) Molecular modification, structural characterization, and biological activity of xylans. Carbohydr Polym 269:118248","journal-title":"Carbohydr Polym"},{"issue":"39","key":"10964_CR77","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.2174\/0929867329666220509112423","volume":"29","author":"S Das","year":"2022","unstructured":"Das S, Roy S, Rahaman SB et al (2022) Structure-activity relationship insight of naturally occurring bioactive molecules and their derivatives against non-small cell lung cancer: a comprehensive review. Curr Med Chem 29(39):6030\u20136062","journal-title":"Curr Med Chem"},{"issue":"23","key":"10964_CR78","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2174\/1568026616666160414123602","volume":"16","author":"RA Khalaf","year":"2016","unstructured":"Khalaf RA (2016) Exploring natural products as a source for antidiabetic lead compounds and possible lead optimization. Curr Top Med Chem 16(23):2549\u20132561","journal-title":"Curr Top Med Chem"},{"issue":"Pt 3","key":"10964_CR79","doi-asserted-by":"crossref","first-page":"137043","DOI":"10.1016\/j.ijbiomac.2024.137043","volume":"282","author":"XY Wang","year":"2024","unstructured":"Wang XY, Chen AQ, Huang J et al (2024) A review on structure, bioactivity, mechanism, structure-activity relationship and application of anti-breast cancer polysaccharides[J]. Int J Biol Macromol 282(Pt 3):137043","journal-title":"Int J Biol Macromol"},{"key":"10964_CR80","volume":"95","author":"YY Chen","year":"2022","unstructured":"Chen YY, Liu QP, An P et al (2022) Ginsenoside rd: a promising natural neuroprotective agent. Phytomedicine 95:153883","journal-title":"Phytomedicine"},{"key":"10964_CR81","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biomaterials.2016.10.045","volume":"113","author":"W Gao","year":"2017","unstructured":"Gao W, Liu Y, Jing G et al (2017) Rapid and efficient crossing blood-brain barrier: hydrophobic drug delivery system based on propionylated amylose helix nanoclusters[J]. Biomaterials 113:133\u2013144","journal-title":"Biomaterials"},{"key":"10964_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010023","author":"G Fontana","year":"2022","unstructured":"Fontana G, Bruno M, Sottile F et al (2022) The chemistry and the anti-inflammatory activity of polymethoxyflavonoids from citrus genus. Antioxidants12(1):23. https:\/\/doi.org\/10.3390\/antiox12010023","journal-title":"Antioxidants"},{"key":"10964_CR83","doi-asserted-by":"crossref","unstructured":"Koss-Mikolajczyk I, Bartoszek \uff082023\uff09 A Relationship between chemical structure and biological activity evaluated in vitro for six anthocyanidins most commonly occurring in edible Plants[J]. Molecules 28(16):6156","DOI":"10.3390\/molecules28166156"},{"key":"10964_CR84","volume":"263","author":"Y Liu","year":"2024","unstructured":"Liu Y, Sun J, Ran Y et al (2024) Synthesis of cinnamoyl tethered Indoline derivatives with anti-inflammatory and antioxidant activities. Eur J Med Chem 263:115936","journal-title":"Eur J Med Chem"},{"issue":"30","key":"10964_CR85","doi-asserted-by":"crossref","first-page":"35456","DOI":"10.1021\/acsami.1c09089","volume":"13","author":"Y Qiao","year":"2021","unstructured":"Qiao Y, Zhang Q, Wang Q et al (2021) Synergistic anti-inflammatory coating zipped up on polypropylene hernia mesh. ACS Appl Mater Interfaces 13(30):35456\u201335468","journal-title":"ACS Appl Mater Interfaces"},{"issue":"27","key":"10964_CR86","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1021\/acs.langmuir.3c00336","volume":"39","author":"N Baccile","year":"2023","unstructured":"Baccile N, Poirier A, Perez J et al (2023) Self-assembly of rhamnolipid bioamphiphiles: understanding the structure-property relationship using small-angle X-ray scattering. Langmuir 39(27):9273\u20139289","journal-title":"Langmuir"},{"issue":"5","key":"10964_CR87","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1021\/acs.jpcb.9b08800","volume":"124","author":"CM Luft","year":"2020","unstructured":"Luft CM, Munusamy E, Pemberton JE et al (2020) A classical molecular dynamics simulation study of interfacial and bulk solution aggregation properties of dirhamnolipids. J Phys Chem B 124(5):814\u2013827","journal-title":"J Phys Chem B"},{"issue":"2","key":"10964_CR88","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jbiosc.2018.07.023","volume":"127","author":"F Pan","year":"2019","unstructured":"Pan F, Hou K, Li DD et al (2019) Exopolysaccharides from the fungal endophytic Fusarium sp. A14 isolated from Fritillaria unibracteata Hsiao et KC Hsia and their antioxidant and antiproliferation effects. J Biosci Bioeng 127(2):231\u2013240","journal-title":"J Biosci Bioeng"},{"issue":"5","key":"10964_CR89","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109777","volume":"27","author":"SG Giannelli","year":"2024","unstructured":"Giannelli SG, Luoni M, Iannielli A et al (2024) New AAV9-engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets. iScience 27(5):109777","journal-title":"iScience"},{"key":"10964_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145547","author":"E Fragopoulou","year":"2023","unstructured":"Fragopoulou E, Gkotsi K, Petsini F et al (2023) Synthesis and biological evaluation of Resveratrol methoxy derivatives. Molecules 28(14):5547. https:\/\/doi.org\/10.3390\/molecules28145547","journal-title":"Molecules"},{"key":"10964_CR91","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124592","author":"T Jin","year":"2023","unstructured":"Jin T, Li N, Wu Y et al (2023) Nobiletin with AIEE characteristics for targeting mitochondria and real-time dynamic tracking in Zebrafish. Molecules 28(12):4592. https:\/\/doi.org\/10.3390\/molecules28124592","journal-title":"Molecules"},{"issue":"9","key":"10964_CR92","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.bmcl.2016.03.074","volume":"26","author":"D Chen","year":"2016","unstructured":"Chen D, Zhao T, Ni K et al (2016) Metabolic investigation on ZL006 to discover a potent prodrug for treating cerebral ischemia[J]. Bioorg Med Chem Lett 26(9):2152\u20132155","journal-title":"Bioorg Med Chem Lett"},{"issue":"7","key":"10964_CR93","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/prot.26679","volume":"92","author":"NN Kochen","year":"2024","unstructured":"Kochen NN, Seaney D, Vasandani V et al (2024) Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: a molecular dynamics study. Proteins 92(7):854\u2013864","journal-title":"Proteins"},{"issue":"5","key":"10964_CR94","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/cbdd.14022","volume":"99","author":"K Wu","year":"2022","unstructured":"Wu K, Peng X, Chen M et al (2022) Recent progress of research on anti-tumor agents using benzimidazole as the structure unit. Chem Biol Drug Des 99(5):736\u2013757","journal-title":"Chem Biol Drug Des"},{"issue":"2","key":"10964_CR95","volume":"36","author":"Q Wu","year":"2022","unstructured":"Wu Q, Wang M, Chen W et al (2022) Daidzein exerts neuroprotective activity against MPTP-induced parkinson\u2019s disease in experimental mice and lipopolysaccharide-induced BV2 microglial cells. J Biochem Mol Toxicol 36(2):e22949","journal-title":"J Biochem Mol Toxicol"},{"key":"10964_CR96","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2022.2089136","author":"GF Yarim","year":"2022","unstructured":"Yarim GF, Kazak F, Yarim M et al (2022) Apigenin alleviates neuroinflammation in a mouse model of Parkinson\u2019s disease. Int J Neurosci 135(5):505\u2013514.https:\/\/doi.org\/10.1080\/00207454.2022.2089136","journal-title":"Int J Neurosci"},{"key":"10964_CR97","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105604","volume":"170","author":"P Sharma","year":"2023","unstructured":"Sharma P, Kishore A, De I et al (2023) Mitigating neuroinflammation in Parkinson\u2019s disease: exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics. Neurochem Int 170:105604","journal-title":"Neurochem Int"},{"issue":"7","key":"10964_CR98","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","volume":"20","author":"N Vijiaratnam","year":"2021","unstructured":"Vijiaratnam N, Simuni T, Bandmann O et al (2021) Progress towards therapies for disease modification in Parkinson\u2019s disease. Lancet Neurol 20(7):559\u2013572","journal-title":"Lancet Neurol"},{"key":"10964_CR99","volume":"12","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wei N, Li X (2020) Preclinical evidence and possible mechanisms of Baicalein for rats and mice with Parkinson\u2019s disease: a systematic review and meta-analysis. Front Aging Neurosci 12:277","journal-title":"Front Aging Neurosci"},{"key":"10964_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112228","author":"JA Evans","year":"2022","unstructured":"Evans JA, Mendonca P, Soliman K (2022) Neuroprotective effects and therapeutic potential of the citrus flavonoid Hesperetin in neurodegenerative diseases. Nutrients14(11):2228. https:\/\/doi.org\/10.3390\/nu14112228","journal-title":"Nutrients"},{"key":"10964_CR101","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112236","volume":"143","author":"E Rodriguez-Arce","year":"2021","unstructured":"Rodriguez-Arce E, Saldias M (2021) Antioxidant properties of flavonoid metal complexes and their potential inclusion in the development of novel strategies for the treatment against neurodegenerative diseases. Biomed Pharmacother 143:112236","journal-title":"Biomed Pharmacother"},{"key":"10964_CR102","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2024.10.048","volume":"563","author":"J Yuan","year":"2024","unstructured":"Yuan J, Dong X, Zhou S et al (2024) Pharmacological activities and therapeutic potential of Hyperoside in treating alzheimer\u2019s and parkinson\u2019s diseases: A systemic review[J]. Neuroscience 563:136\u2013147","journal-title":"Neuroscience"},{"issue":"4","key":"10964_CR103","doi-asserted-by":"crossref","first-page":"474","DOI":"10.18388\/pb.2021_563","volume":"70","author":"I Sergiel","year":"2024","unstructured":"Sergiel I (2024) Flavonoids - natural compounds with antiviral and anticancer potential. Postepy Biochem 70(4):474\u2013482","journal-title":"Postepy Biochem"},{"key":"10964_CR104","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175627","author":"J Dong","year":"2022","unstructured":"Dong J, Zhou K, Ge X et al (2022) Effects of extraction technique on the content and antioxidant activity of flavonoids from Gossypium hirsutum Linn. flowers. Molecules27(17):5627. https:\/\/doi.org\/10.3390\/molecules27175627","journal-title":"Molecules"},{"issue":"25","key":"10964_CR105","doi-asserted-by":"crossref","first-page":"22586","DOI":"10.1074\/jbc.M101846200","volume":"276","author":"LA Stivala","year":"2001","unstructured":"Stivala LA, Savio M, Carafoli F et al (2001) Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J Biol Chem 276(25):22586\u201322594","journal-title":"J Biol Chem"},{"key":"10964_CR106","doi-asserted-by":"crossref","unstructured":"Rodriguez-Landa JF, German-Ponciano LJ, Puga-Olguin A et al (2022) Pharmacological, neurochemical and behavioral mechanisms underlying the Anxiolytic- and Antidepressant-like effects of flavonoid Chrysin[J]. Molecules, 27(11)","DOI":"10.3390\/molecules27113551"},{"key":"10964_CR107","doi-asserted-by":"crossref","first-page":"1216948","DOI":"10.3389\/fphys.2023.1216948","volume":"14","author":"DK Joseph","year":"2023","unstructured":"Joseph DK, Mat LA, Ibrahim FW et al (2023) Effects of aerobic exercise and dietary flavonoids on cognition: a systematic review and meta-analysis[J]. Front Physiol 14:1216948","journal-title":"Front Physiol"},{"issue":"3","key":"10964_CR108","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10787-025-01698-x","volume":"33","author":"OK Kuwar","year":"2025","unstructured":"Kuwar OK, Kalia N (2025) Anti-inflammatory and antioxidant effects of baicalein: targeting Nrf2, and NFkB in neurodegenerative disease. Inflammopharmacology 33(3):1303\u20131310","journal-title":"Inflammopharmacology"},{"key":"10964_CR109","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102299","volume":"97","author":"S Hassani","year":"2024","unstructured":"Hassani S, Esmaeili A (2024) The neuroprotective effects of ferulic acid in toxin-induced models of parkinson\u2019s disease: a review. Ageing Res Rev 97:102299","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10964_CR110","first-page":"87","volume":"53","author":"A Le Bras","year":"2024","unstructured":"Le Bras A (2024) Humanized mouse models of drug metabolism. Lab Anim 53(4):87","journal-title":"Lab Anim"},{"issue":"2","key":"10964_CR111","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3109\/00498254.2013.815831","volume":"44","author":"N Scheer","year":"2014","unstructured":"Scheer N, Wolf CR (2014) Genetically humanized mouse models of drug-metabolizing enzymes and transporters and their applications. Xenobiotica 44(2):96\u2013108","journal-title":"Xenobiotica"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10964-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10964-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10964-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:05:05Z","timestamp":1766898305000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10964-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":111,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10964"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10964-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"966"}}