{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:20:25Z","timestamp":1780449625721,"version":"3.54.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010760","name":"Y\u00fcz\u00fcnc\u00fc Yil \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYD-2021-9342"],"award-info":[{"award-number":["TYD-2021-9342"]}],"id":[{"id":"10.13039\/501100010760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-10977-3","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:52:15Z","timestamp":1757577135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GSK-3 inhibitor induces apoptosis and cell cycle arrest in CD133+\/CD44+ prostate cancer cells through modulation of Notch signaling pathway"],"prefix":"10.1007","volume":"52","author":[{"given":"Eda","family":"Acikgoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrin","family":"Ozdil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulperi","family":"Oktem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Aktug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat Cetin","family":"Ragbetli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cafer","family":"Tas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"10977_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel R et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"10977_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.935715","author":"I Wolf","year":"2022","unstructured":"Wolf I, Gratzke C, Wolf P (2022) Prostate cancer stem cells: clinical aspects and targeted therapies. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.935715","journal-title":"Front Oncol"},{"key":"10977_CR3","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1007\/s11033-021-06387-w","volume":"48","author":"E Acikgoz","year":"2021","unstructured":"Acikgoz E, Mukhtarova G, Alpay A et al (2021) Sonic hedgehog signaling is associated with resistance to zoledronic acid in CD133high\/CD44high prostate cancer stem cells. Mol Biol Rep 48:3567\u20133578. https:\/\/doi.org\/10.1007\/s11033-021-06387-w","journal-title":"Mol Biol Rep"},{"key":"10977_CR4","doi-asserted-by":"publisher","first-page":"10946","DOI":"10.1158\/0008-5472.CAN-05-2018","volume":"65","author":"AT Collins","year":"2005","unstructured":"Collins AT, Berry PA, Hyde C et al (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65:10946\u201310951. https:\/\/doi.org\/10.1158\/0008-5472.CAN-05-2018","journal-title":"Cancer Res"},{"key":"10977_CR5","doi-asserted-by":"publisher","first-page":"6796","DOI":"10.1158\/0008-5472.CAN-07-0490","volume":"67","author":"L Patrawala","year":"2007","unstructured":"Patrawala L, Calhoun-Davis T, Schneider-Broussard R, Tang DG (2007) Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44\u2009+\u2009\u03b12\u03b21\u2009+\u2009cell population is enriched in tumor-initiating cells. Cancer Res 67:6796\u20136805. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-0490","journal-title":"Cancer Res"},{"key":"10977_CR6","doi-asserted-by":"crossref","unstructured":"Blagoev KB, Iordanov R, Zhou M et al (2020) Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer, vol 12. Oncotarget, 1","DOI":"10.18632\/oncotarget.27855"},{"key":"10977_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4067\/S0716-97602012000300011","volume":"45","author":"EA Castell\u00f3n","year":"2012","unstructured":"Castell\u00f3n EA, Valenzuela R, Lillo J et al (2012) Molecular signature of cancer stem cells isolated from prostate carcinoma and expression of stem markers in different Gleason grades and metastasis. Biol Res 45:297\u2013305. https:\/\/doi.org\/10.4067\/S0716-97602012000300011","journal-title":"Biol Res"},{"key":"10977_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.650772","author":"V Kumar","year":"2021","unstructured":"Kumar V, Vashishta M, Kong L et al (2021) The role of notch, hedgehog, and Wnt signaling pathways in the resistance of tumors to anticancer therapies. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2021.650772","journal-title":"Front Cell Dev Biol"},{"key":"10977_CR9","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s13287-020-01773-w","volume":"11","author":"L Wang","year":"2020","unstructured":"Wang L, Zi H, Luo Y et al (2020) Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells. Stem Cell Res Ther 11:258. https:\/\/doi.org\/10.1186\/s13287-020-01773-w","journal-title":"Stem Cell Res Ther"},{"key":"10977_CR10","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/15384101.2017.1312237","volume":"16","author":"L Zhang","year":"2017","unstructured":"Zhang L, Sha J, Yang G et al (2017) Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells. Cell Cycle 16:999\u20131007. https:\/\/doi.org\/10.1080\/15384101.2017.1312237","journal-title":"Cell Cycle"},{"key":"10977_CR11","doi-asserted-by":"publisher","first-page":"627","DOI":"10.21037\/tau-22-281","volume":"11","author":"Y Qing","year":"2022","unstructured":"Qing Y, Wang Y, Hu C et al (2022) Evaluation of NOTCH family genes\u2019 expression and prognostic value in prostate cancer. Transl Androl Urol 11:627\u2013642. https:\/\/doi.org\/10.21037\/tau-22-281","journal-title":"Transl Androl Urol"},{"key":"10977_CR12","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.3892\/ol.2014.1992","volume":"7","author":"G Oktem","year":"2014","unstructured":"Oktem G, Bilir A, Uslu R et al (2014) Expression profiling of stem cell signaling alters with spheroid formation in CD133high\/CD44high prostate cancer stem cells. Oncol Lett 7:2103\u20132109. https:\/\/doi.org\/10.3892\/ol.2014.1992","journal-title":"Oncol Lett"},{"key":"10977_CR13","first-page":"2077","volume":"29","author":"R Li","year":"2009","unstructured":"Li R, Erdamar S, Dai H et al (2009) Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer. Anticancer Res 29:2077\u20132081","journal-title":"Anticancer Res"},{"key":"10977_CR14","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.urolonc.2015.05.006","volume":"33","author":"B Li","year":"2015","unstructured":"Li B, Thrasher JB, Terranova P (2015) Glycogen synthase kinase-3: a potential preventive target for prostate cancer management. Urol Oncol 33:456\u2013463. https:\/\/doi.org\/10.1016\/j.urolonc.2015.05.006","journal-title":"Urol Oncol"},{"key":"10977_CR15","doi-asserted-by":"publisher","first-page":"7882","DOI":"10.1038\/sj.onc.1208068","volume":"23","author":"M Mazor","year":"2004","unstructured":"Mazor M, Kawano Y, Zhu H et al (2004) Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. Oncogene 23:7882\u20137892. https:\/\/doi.org\/10.1038\/sj.onc.1208068","journal-title":"Oncogene"},{"key":"10977_CR16","doi-asserted-by":"publisher","first-page":"e25341","DOI":"10.1371\/journal.pone.0025341","volume":"6","author":"SV Sch\u00fctz","year":"2011","unstructured":"Sch\u00fctz SV, Schrader AJ, Zengerling F et al (2011) Inhibition of glycogen synthase kinase-3\u03b2 counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer. PLoS One 6:e25341. https:\/\/doi.org\/10.1371\/journal.pone.0025341","journal-title":"PLoS One"},{"key":"10977_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118738","volume":"1867","author":"FE Bertrand","year":"2020","unstructured":"Bertrand FE (2020) The cross-talk of NOTCH and GSK-3 signaling in colon and other cancers. Biochimica et Biophysica Acta (BBA) 1867:118738. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118738","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"10977_CR18","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3390\/cells9051110","volume":"9","author":"P Duda","year":"2020","unstructured":"Duda P, Akula SM, Abrams SL et al (2020) Targeting GSK3 and associated signaling pathways involved in cancer. Cells 9:1110. https:\/\/doi.org\/10.3390\/cells9051110","journal-title":"Cells"},{"key":"10977_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1091\/mbc.E17-07-0474","volume":"29","author":"L Zheng","year":"2018","unstructured":"Zheng L, Conner SD (2018) Glycogen synthase kinase 3\u03b2 inhibition enhances Notch1 recycling. Mol Biol Cell 29:389\u2013395. https:\/\/doi.org\/10.1091\/mbc.E17-07-0474","journal-title":"Mol Biol Cell"},{"key":"10977_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.saa.2018.10.036","volume":"209","author":"E Acikgoz","year":"2019","unstructured":"Acikgoz E, G\u00fcler G, Camlar M et al (2019) Glycogen synthase kinase-3 inhibition in glioblastoma multiforme cells induces apoptosis, cell cycle arrest and changing biomolecular structure. Spectrochim Acta A Mol Biomol Spectrosc 209:150\u2013164. https:\/\/doi.org\/10.1016\/j.saa.2018.10.036","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10977_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108684","volume":"107","author":"E Acikgoz","year":"2022","unstructured":"Acikgoz E, Duzagac F, Guven U et al (2022) Double hit strategy: removal of Sialic acid from the dendritic cell surface and loading with CD44+\/CD24-\/low cell lysate inhibits tumor growth and metastasis by targeting breast cancer stem cells. Int Immunopharmacol 107:108684. https:\/\/doi.org\/10.1016\/j.intimp.2022.108684","journal-title":"Int Immunopharmacol"},{"key":"10977_CR22","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/pros.24690","volume":"84","author":"Y Dwina","year":"2024","unstructured":"Dwina Y, Zaid LSM, Saraswati M et al (2024) CD44 and CD133 protein expression might serve as a prognostic factor for early occurrence castration-resistant prostate cancer. Prostate 84:738\u2013746. https:\/\/doi.org\/10.1002\/pros.24690","journal-title":"Prostate"},{"key":"10977_CR23","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s12253-016-0169-z","volume":"23","author":"E Kalantari","year":"2017","unstructured":"Kalantari E, Asgari M, Nikpanah S et al (2017) Co-expression of putative cancer stem cell markers CD44 and CD133 in prostate carcinomas. Pathol Oncol Res 23:793\u2013802. https:\/\/doi.org\/10.1007\/s12253-016-0169-z","journal-title":"Pathol Oncol Res"},{"key":"10977_CR24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/cr.2009.43","volume":"19","author":"I Bisson","year":"2009","unstructured":"Bisson I, Prowse DM (2009) WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 19:683\u2013697. https:\/\/doi.org\/10.1038\/cr.2009.43","journal-title":"Cell Res"},{"key":"10977_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.canlet.2018.05.014","volume":"430","author":"R Kanwal","year":"2018","unstructured":"Kanwal R, Shukla S, Walker E, Gupta S (2018) Acquisition of tumorigenic potential and therapeutic resistance in CD133\u2009+\u2009subpopulation of prostate cancer cells exhibiting stem-cell like characteristics. Cancer Lett 430:25\u201333. https:\/\/doi.org\/10.1016\/j.canlet.2018.05.014","journal-title":"Cancer Lett"},{"key":"10977_CR26","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/sj.onc.1209327","volume":"25","author":"L Patrawala","year":"2006","unstructured":"Patrawala L, Calhoun T, Schneider-Broussard R et al (2006) Highly purified CD44\u2009+\u2009prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25:1696\u20131708. https:\/\/doi.org\/10.1038\/sj.onc.1209327","journal-title":"Oncogene"},{"key":"10977_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2021.151743","volume":"123","author":"E Acikgoz","year":"2021","unstructured":"Acikgoz E, Soner BC, Ozdil B, Guven M (2021) CD133+\/CD44\u2009+\u2009prostate cancer stem cells exhibit embryo-like behavior patterns. Acta Histochem 123:151743. https:\/\/doi.org\/10.1016\/j.acthis.2021.151743","journal-title":"Acta Histochem"},{"key":"10977_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127375","volume":"253","author":"R Thapa","year":"2023","unstructured":"Thapa R, Gupta G, Bhat AA et al (2023) A review of glycogen synthase Kinase-3 (GSK3) inhibitors for cancers therapies. Int J Biol Macromol 253:127375. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.127375","journal-title":"Int J Biol Macromol"},{"key":"10977_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27620","volume":"131","author":"RS Darrington","year":"2012","unstructured":"Darrington RS, Campa VM, Walker MM et al (2012) Distinct expression and activity of GSK-3\u03b1 and GSK-3\u03b2 in prostate cancer. Int J Cancer 131:E872\u2013E883. https:\/\/doi.org\/10.1002\/ijc.27620","journal-title":"Int J Cancer"},{"key":"10977_CR30","doi-asserted-by":"publisher","first-page":"775","DOI":"10.18632\/oncotarget.1770","volume":"5","author":"A Goc","year":"2014","unstructured":"Goc A, Al-Husein B, Katsanevas K et al (2014) Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo. Oncotarget 5:775\u2013787. https:\/\/doi.org\/10.18632\/oncotarget.1770","journal-title":"Oncotarget"},{"key":"10977_CR31","doi-asserted-by":"publisher","first-page":"5947","DOI":"10.18632\/oncotarget.3335","volume":"6","author":"F Gao","year":"2015","unstructured":"Gao F, Al-Azayzih A, Somanath PR (2015) Discrete functions of GSK3\u03b1 and GSK3\u03b2 isoforms in prostate tumor growth and micrometastasis. Oncotarget 6:5947\u20135962. https:\/\/doi.org\/10.18632\/oncotarget.3335","journal-title":"Oncotarget"},{"key":"10977_CR32","doi-asserted-by":"publisher","unstructured":"Kroon J et al (2014) in \u2019t Veld LS, Buijs JT, Glycogen synthase kinase-3\u03b2 inhibition depletes the population of prostate cancer stem\/progenitor-like cells and attenuates metastatic growth. Oncotarget 5:8986\u20138994. https:\/\/doi.org\/10.18632\/oncotarget.1510","DOI":"10.18632\/oncotarget.1510"},{"key":"10977_CR33","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.3892\/or.2018.6600","volume":"40","author":"S Liao","year":"2018","unstructured":"Liao S, Gan L, Qin W et al (2018) Inhibition of GSK3 and MEK induced cancer stem cell generation via the Wnt and MEK signaling pathways. Oncol Rep 40:2005\u20132013. https:\/\/doi.org\/10.3892\/or.2018.6600","journal-title":"Oncol Rep"},{"key":"10977_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13058-019-1125-0","volume":"21","author":"GV Vijay","year":"2019","unstructured":"Vijay GV, Zhao N, Den Hollander P et al (2019) GSK3\u03b2 regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res 21:37. https:\/\/doi.org\/10.1186\/s13058-019-1125-0","journal-title":"Breast Cancer Res"},{"key":"10977_CR35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.taap.2017.07.008","volume":"330","author":"A Nayak","year":"2017","unstructured":"Nayak A, Siddharth S, Das S et al (2017) Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and \u03b2 catenin through activation of GSK3\u03b2. Toxicol Appl Pharmacol 330:53\u201364. https:\/\/doi.org\/10.1016\/j.taap.2017.07.008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10977_CR36","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbrc.2020.12.055","volume":"554","author":"D Wei","year":"2021","unstructured":"Wei D, Zhu X, Li S et al (2021) Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3\u03b2\/NOTCH1 signaling. Biochem Biophys Res Commun 554:206\u2013213. https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.055","journal-title":"Biochem Biophys Res Commun"},{"key":"10977_CR37","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s43440-020-00162-7","volume":"73","author":"HF Bahmad","year":"2021","unstructured":"Bahmad HF, Chalhoub RM, Harati H et al (2021) Tideglusib attenuates growth of neuroblastoma cancer stem\/progenitor cells in vitro and in vivo by specifically targeting GSK-3\u03b2. Pharmacol Rep 73:211\u2013226. https:\/\/doi.org\/10.1007\/s43440-020-00162-7","journal-title":"Pharmacol Rep"},{"key":"10977_CR38","doi-asserted-by":"publisher","first-page":"19977","DOI":"10.1038\/s41598-019-56461-4","volume":"9","author":"H Kuroki","year":"2019","unstructured":"Kuroki H, Anraku T, Kazama A et al (2019) 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer. Sci Rep 9:19977. https:\/\/doi.org\/10.1038\/s41598-019-56461-4","journal-title":"Sci Rep"},{"key":"10977_CR39","doi-asserted-by":"publisher","first-page":"13249","DOI":"10.1038\/srep13249","volume":"5","author":"Y Yoshino","year":"2015","unstructured":"Yoshino Y, Ishioka C (2015) Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Sci Rep 5:13249. https:\/\/doi.org\/10.1038\/srep13249","journal-title":"Sci Rep"},{"key":"10977_CR40","doi-asserted-by":"publisher","first-page":"8173","DOI":"10.18632\/oncotarget.2303","volume":"5","author":"VM Campa","year":"2014","unstructured":"Campa VM, Baltziskueta E, Bengoa-Vergniory N et al (2014) A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NF\u03baB and androgen receptor signaling in prostate cancer. Oncotarget 5:8173\u20138187. https:\/\/doi.org\/10.18632\/oncotarget.2303","journal-title":"Oncotarget"},{"key":"10977_CR41","doi-asserted-by":"publisher","first-page":"32227","DOI":"10.1074\/jbc.M304001200","volume":"278","author":"L Espinosa","year":"2003","unstructured":"Espinosa L, Ingl\u00e9s-Esteve J, Aguilera C, Bigas A (2003) Phosphorylation by glycogen synthase kinase-3\u03b2 down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem 278:32227\u201332235. https:\/\/doi.org\/10.1074\/jbc.M304001200","journal-title":"J Biol Chem"},{"key":"10977_CR42","first-page":"368","volume":"5","author":"H Zhu","year":"2013","unstructured":"Zhu H, Zhou X, Redfield S et al (2013) Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers. Am J Translational Res 5:368\u2013378","journal-title":"Am J Translational Res"},{"key":"10977_CR43","doi-asserted-by":"publisher","first-page":"6854","DOI":"10.1158\/0008-5472.CAN-04-2500","volume":"64","author":"S Santagata","year":"2004","unstructured":"Santagata S, Demichelis F, Riva A et al (2004) Jagged1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res 64:6854\u20136857. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-2500","journal-title":"Cancer Res"},{"key":"10977_CR44","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/s0960-9822(02)00888-6","volume":"12","author":"DR Foltz","year":"2002","unstructured":"Foltz DR, Santiago MC, Berechid BE, Nye JS (2002) Glycogen synthase kinase-3beta modulates Notch signaling and stability. Curr Biology: CB 12:1006\u20131011. https:\/\/doi.org\/10.1016\/s0960-9822(02)00888-6","journal-title":"Curr Biology: CB"},{"key":"10977_CR45","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.194.7.991","volume":"194","author":"AC Jaleco","year":"2001","unstructured":"Jaleco AC, Neves H, Hooijberg E et al (2001) Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med 194:991\u20131002. https:\/\/doi.org\/10.1084\/jem.194.7.991","journal-title":"J Exp Med"},{"key":"10977_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2023.102244","volume":"85","author":"F Suarez Rodriguez","year":"2023","unstructured":"Suarez Rodriguez F, Sanlidag S, Sahlgren C (2023) Mechanical regulation of the Notch signaling pathway. Curr Opin Cell Biol 85:102244. https:\/\/doi.org\/10.1016\/j.ceb.2023.102244","journal-title":"Curr Opin Cell Biol"},{"key":"10977_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110569","author":"AA Pujar","year":"2024","unstructured":"Pujar AA, Barua A, Dey PS et al (2024) Microenvironmental entropy dynamics analysis reveals novel insights into Notch-Delta-Jagged decision-making mechanism. iScience. https:\/\/doi.org\/10.1016\/j.isci.2024.110569","journal-title":"iScience"},{"key":"10977_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10059-009-0001-7","volume":"27","author":"YH Jin","year":"2009","unstructured":"Jin YH, Kim H, Oh M et al (2009) Regulation of Notch1\/NICD and Hes1 expressions by GSK-3alpha\/beta. Mol Cells 27:15\u201319. https:\/\/doi.org\/10.1007\/s10059-009-0001-7","journal-title":"Mol Cells"},{"key":"10977_CR49","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.bbrc.2012.05.111","volume":"423","author":"X Han","year":"2012","unstructured":"Han X, Ju J, Shin I (2012) Glycogen synthase kinase 3-\u03b2 phosphorylates novel S\/T-P-S\/T domains in Notch1 intracellular domain and induces its nuclear localization. Biochem Biophys Res Commun 423:282\u2013288. https:\/\/doi.org\/10.1016\/j.bbrc.2012.05.111","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10977-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-10977-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-10977-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:03:56Z","timestamp":1766898236000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-10977-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10977"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-10977-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"11 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"892"}}