{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:04:57Z","timestamp":1766901897513,"version":"3.48.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["File No: YSS\/2014\/000073"],"award-info":[{"award-number":["File No: YSS\/2014\/000073"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["Ref. No. F. 30-60\/2014(BSR)"],"award-info":[{"award-number":["Ref. No. F. 30-60\/2014(BSR)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-11022-z","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:42:45Z","timestamp":1758634965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding diabetic encephalopathy: a model-based approach to explore cognitive and motor impairments through glutamatergic dysregulation"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-1476","authenticated-orcid":false,"given":"Debashree","family":"Mazumdar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-1483","authenticated-orcid":false,"given":"Santosh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"issue":"22","key":"11022_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212366","volume":"22","author":"FC Pignalosa","year":"2021","unstructured":"Pignalosa FC, Desiderio A, Mirra P, Nigro C, Perruolo G, Ulianich L, Formisano P, Beguinot F, Miele C, Napoli R, Fiory F (2021) Diabetes and cognitive impairment: a role for glucotoxicity and dopaminergic dysfunction. Int J Mol Sci 22(22):12366. https:\/\/doi.org\/10.3390\/ijms222212366","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11022_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12291-022-01107-y","volume":"39","author":"D Mazumdar","year":"2024","unstructured":"Mazumdar D, Singh S (2024) Diabetic encephalopathy: role of oxidative and nitrosative factors in type 2 diabetes. Indian J Clin Biochemistry: IJCB 39(1):3\u201317. https:\/\/doi.org\/10.1007\/s12291-022-01107-y","journal-title":"Indian J Clin Biochemistry: IJCB"},{"issue":"9","key":"11022_CR3","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2174\/1871527317666180809092359","volume":"17","author":"NK Mule","year":"2018","unstructured":"Mule NK, Singh JN (2018) Diabetes mellitus to neurodegenerative disorders: is oxidative stress fueling the flame? CNS & Neurological Disorders 17(9):644\u2013653","journal-title":"CNS & Neurological Disorders"},{"key":"11022_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ibneur.2022.12.006","volume":"14","author":"M Gupta","year":"2023","unstructured":"Gupta M, Pandey S, Rumman M, Singh B, Mahdi AA (2023) Molecular mechanisms underlying hyperglycemia associated cognitive decline. IBRO Neurosci Rep 14:57\u201363","journal-title":"IBRO Neurosci Rep"},{"issue":"8","key":"11022_CR5","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/j.neubiorev.2013.03.010","volume":"37","author":"N Ho","year":"2013","unstructured":"Ho N, Sommers MS, Lucki I (2013) Effects of diabetes on hippocampal neurogenesis: links to cognition and depression. Neurosci Biobehav Rev 37(8):1346\u20131362","journal-title":"Neurosci Biobehav Rev"},{"issue":"8","key":"11022_CR6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s13205-020-02354-7","volume":"10","author":"WT Xuan","year":"2020","unstructured":"Xuan WT, Wang H, Zhou P, Ye T, Gao HW, Ye S, Wang JH, Chen ML, Song H, Wang Y, Cai B (2020) Berberine ameliorates rats model of combined Alzheimer\u2019s disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress. 3 Biotech 10(8):359","journal-title":"3 Biotech"},{"key":"11022_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153686","volume":"91","author":"YM Zhang","year":"2021","unstructured":"Zhang YM, Zheng T, Huang TT, Gu PP, Gou LS, Ma TF, Liu YW (2021) Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes. Phytomedicine 91:153686","journal-title":"Phytomedicine"},{"issue":"7","key":"11022_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271138","volume":"17","author":"SK Ali","year":"2022","unstructured":"Ali SK, Ali RH (2022) Effects of antidiabetic agents on Alzheimer\u2019s disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. PLoS ONE 17(7):e0271138","journal-title":"PLoS ONE"},{"issue":"1","key":"11022_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12964-023-01097-1","volume":"21","author":"L Cheng","year":"2023","unstructured":"Cheng L, Chen Y, Guo D, Zhong Y, Li W, Lin Y, Miao Y (2023) mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer\u2019s disease-like pathology in diabetic encephalopathy. Cell Communication Signal 21(1):91","journal-title":"Cell Communication Signal"},{"issue":"10","key":"11022_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrneurol.2010.130","volume":"6","author":"C Sims-Robinson","year":"2010","unstructured":"Sims-Robinson C, Kim B, Rosko A, Feldman EL (2010) How does diabetes accelerate Alzheimer disease pathology? Nat Rev Neurol 6(10):551\u2013559","journal-title":"Nat Rev Neurol"},{"key":"11022_CR11","first-page":"274","volume":"22","author":"A Ghasemi","year":"2023","unstructured":"Ghasemi A, Jeddi S (2023) Streptozotocin as a tool for induction of rat models of diabetes: a practical guide. EXCLI J 22:274","journal-title":"EXCLI J"},{"issue":"9","key":"11022_CR12","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3390\/biom12091225","volume":"12","author":"LJ Yan","year":"2022","unstructured":"Yan LJ (2022) The nicotinamide\/streptozotocin rodent model of type 2 diabetes: renal pathophysiology and redox imbalance features. Biomolecules 12(9):1225","journal-title":"Biomolecules"},{"key":"11022_CR13","doi-asserted-by":"crossref","unstructured":"Tyurenkov IN, Bakulin DA, Smirnov AV, Ekova MR, Bisinbekova AI, Snigur GL, Vasilyeva OS (2023) Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals. Sci Practical J, 211","DOI":"10.19163\/2307-9266-2023-11-3-211-227"},{"issue":"1","key":"11022_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"R Morris","year":"1984","unstructured":"Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47\u201360","journal-title":"J Neurosci Methods"},{"issue":"8","key":"11022_CR15","doi-asserted-by":"publisher","DOI":"10.4249\/scholarpedia.6315","volume":"3","author":"RG Morris","year":"2008","unstructured":"Morris RG (2008) Morris water maze. Scholarpedia 3(8):6315","journal-title":"Scholarpedia"},{"issue":"4","key":"11022_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1037\/h0026818","volume":"10","author":"EE Jones","year":"1968","unstructured":"Jones EE, Rock L, Shaver KG, Goethals GR, Ward LM (1968) Pattern of performance and ability attribution: an unexpected primacy effect. J Personal Soc Psychol 10(4):317","journal-title":"J Personal Soc Psychol"},{"issue":"1","key":"11022_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1254\/jjp.27.117","volume":"27","author":"H Kuribara","year":"1977","unstructured":"Kuribara H, Higuchi Y, Tadokoro S (1977) Effects of central depressants on rota rod and traction performances in mice. Jpn J Pharmacol 27(1):117\u2013126","journal-title":"Jpn J Pharmacol"},{"issue":"5","key":"11022_CR18","first-page":"1295","volume":"88","author":"AB Kulkarni","year":"1999","unstructured":"Kulkarni AB (1999) Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. J Neurochem 88(5):1295\u20131304","journal-title":"J Neurochem"},{"issue":"1","key":"11022_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"issue":"1","key":"11022_CR20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/000456326900600108","volume":"6","author":"P Trinder","year":"1969","unstructured":"Trinder P (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 6(1):24\u201327","journal-title":"Ann Clin Biochem"},{"issue":"1","key":"11022_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-9861(85)90833-1","volume":"239","author":"RA Shankar","year":"1985","unstructured":"Shankar RA, Anderson PM (1985) Purification and properties of glutamine synthetase from liver of Squalus acanthias. Arch Biochem Biophys 239(1):248\u2013259","journal-title":"Arch Biochem Biophys"},{"issue":"20","key":"11022_CR22","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1212\/WNL.0b013e3181bd110f","volume":"73","author":"SB Jeon","year":"2009","unstructured":"Jeon SB, Kwon SU, Cho AH, Yun SC, Kim JS, Kang DW (2009) Rapid appearance of new cerebral microbleeds after acute ischemic stroke. Neurology 73(20):1638\u20131644","journal-title":"Neurology"},{"issue":"1","key":"11022_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17134-2","volume":"7","author":"IK Singh","year":"2014","unstructured":"Singh IK, Singh S, Mogilicherla K, Shukla JN, Palli SR (2014) Comparative analysis of double-stranded RNA degradation and processing in insects. Sci Rep 7(1):17059","journal-title":"Sci Rep"},{"issue":"4","key":"11022_CR24","doi-asserted-by":"publisher","first-page":"937","DOI":"10.3233\/JAD-121762","volume":"34","author":"Y Zhou","year":"2013","unstructured":"Zhou Y, Luo Y, Dai J (2013) Axonal and dendritic changes are associated with diabetic encephalopathy in rats: an important risk factor for Alzheimer\u2019s disease. J Alzheimers Dis 34(4):937\u2013947","journal-title":"J Alzheimers Dis"},{"key":"11022_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.phrs.2013.12.005","volume":"80","author":"R Singh","year":"2014","unstructured":"Singh R, Kishore L, Kaur N (2014) Diabetic peripheral neuropathy: current perspective and future directions. Pharmacol Res 80:21\u201335","journal-title":"Pharmacol Res"},{"issue":"3","key":"11022_CR26","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.diabres.2007.01.021","volume":"77","author":"KD Kohnert","year":"2007","unstructured":"Kohnert KD, Augstein P, Heinke P, Zander E, Peterson K, Freyse EJ, Salzsieder E (2007) Chronic hyperglycemia but not glucose variability determines HbA1c levels in well-controlled patients with type 2 diabetes. Diabetes Res Clin Pract 77(3):420\u2013426","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"11022_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae201","volume":"13","author":"AA Sahu","year":"2024","unstructured":"Sahu AA, Mukherjee A, Nirala SK, Bhadauria M (2024) Cyclophosphamide-induced multiple organ dysfunctions: unravelling of dose dependent toxic impact on biochemistry and histology. Toxicol Res 13(6):tfae201","journal-title":"Toxicol Res"},{"key":"11022_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12291-017-0661-6","volume":"33","author":"HB Atya","year":"2018","unstructured":"Atya HB, Ali SA, Hegazy MI, El Sharkawi FZ (2018) Urinary urea, uric acid and hippuric acid as potential biomarkers in multiple sclerosis patients. Indian J Clin Biochem 33:163\u2013170","journal-title":"Indian J Clin Biochem"},{"issue":"6","key":"11022_CR29","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/jdi.13303","volume":"11","author":"L Fan","year":"2020","unstructured":"Fan L, Cacicedo JM, Ido Y (2020) Impaired nicotinamide adenine dinucleotide (NAD+) metabolism in diabetes and diabetic tissues: implications for nicotinamide-related compound treatment. J Diabetes Invest 11(6):1403\u20131419","journal-title":"J Diabetes Invest"},{"key":"11022_CR30","doi-asserted-by":"publisher","first-page":"106412","DOI":"10.1016\/j.psyneuen.2023.106412","volume":"159","author":"Q Xiang","year":"2024","unstructured":"Xiang Q, Tao JS, Dong S, Liu XL, Yang L, Liu LN, Li XH (2024) Heterogeneity and synaptic plasticity analysis of hippocampus based on db-\/-mice induced diabetic encephalopathy. Psychoneuroendocrinology 159:106412","journal-title":"Psychoneuroendocrinology"},{"key":"11022_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/BF00417687","volume":"37","author":"GJ Biessels","year":"1994","unstructured":"Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH (1994) Cerebral function in diabetes mellitus. Diabetologia 37:643\u2013650","journal-title":"Diabetologia"},{"issue":"2","key":"11022_CR32","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11011-023-01299-z","volume":"39","author":"M Hristov","year":"2024","unstructured":"Hristov M, Nankova A, Andreeva-Gateva P (2024) Alterations of the glutamatergic system in diabetes mellitus. Metab Brain Dis 39(2):321\u2013333","journal-title":"Metab Brain Dis"},{"issue":"1","key":"11022_CR33","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v3i1.113","volume":"3","author":"Q Ding","year":"2022","unstructured":"Ding Q, Yu Q, Tao L, Guo Y, Zhao J, Yu J (2022) DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments. STEMedicine 3(1):e113","journal-title":"STEMedicine"},{"key":"11022_CR34","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00702-014-1193-3","volume":"121","author":"M Levite","year":"2014","unstructured":"Levite M (2014) Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A\/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, sjogren\u2019s syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate. \u2026 J Neural Transmission 121:1029\u20131075","journal-title":"\u2026 J Neural Transmission"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11022-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11022-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11022-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:03:52Z","timestamp":1766898232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11022-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["11022"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11022-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"21 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research protocol of this study sincerely followed the guidelines of animal studies. The approval was granted by the institutional animal ethical committee (IAEC), Guru Ghasidas Vishwavidyalaya, Bilaspur, C.G., India (Ref. No. 994\/GO\/Re\/S\/06\/CPCSEA). Accordingly, the experiment was carried on as approved by the IAEC.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"945"}}