{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:06:40Z","timestamp":1791209200682,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-11044-7","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:55:54Z","timestamp":1758549354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the influence of oleic and palmitic acids on inflammatory markers and gut barrier integrity in a celiac disease Caco-2 model"],"prefix":"10.1007","volume":"52","author":[{"given":"Behrooz","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolrahim","family":"Nikzamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Sirati-Sabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Asri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-1831","authenticated-orcid":false,"given":"Mohammad","family":"Rostami-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"10344","key":"11044_CR1","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","volume":"399","author":"C Catassi","year":"2022","unstructured":"Catassi C, Verdu EF, Bai JC, Lionetti E (2022) Coeliac disease. Lancet 399(10344):2413\u20132426","journal-title":"Lancet"},{"key":"11044_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1049623","volume":"9","author":"G Mamone","year":"2022","unstructured":"Mamone G, Di Stasio L, Vitale S et al (2022) Analytical and functional approaches to assess the immunogenicity of gluten proteins. Front Nutr 9:1049623","journal-title":"Front Nutr"},{"key":"11044_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/TACG.S276596","volume":"14","author":"N Asri","year":"2021","unstructured":"Asri N, Rostami-Nejad M, Anderson RP, Rostami K (2021) The gluten gene: unlocking the understanding of gluten sensitivity and intolerance. Appl Clin Genet 14:37\u201350","journal-title":"Appl Clin Genet"},{"key":"11044_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/bs.ircmb.2020.09.007","volume":"358","author":"C Escudero-Hern\u00e1ndez","year":"2021","unstructured":"Escudero-Hern\u00e1ndez C (2021) Epithelial cell dysfunction in coeliac disease. Int Rev Cell Mol Biol 358:133\u2013164","journal-title":"Int Rev Cell Mol Biol"},{"issue":"11","key":"11044_CR5","doi-asserted-by":"publisher","first-page":"e113932","DOI":"10.1371\/journal.pone.0113932","volume":"9","author":"C Zimmermann","year":"2014","unstructured":"Zimmermann C, Rudloff S, Lochnit G et al (2014) Epithelial transport of immunogenic and toxic Gliadin peptides in vitro. PLoS ONE 9(11):e113932","journal-title":"PLoS ONE"},{"issue":"6","key":"11044_CR6","doi-asserted-by":"publisher","first-page":"326","DOI":"10.4321\/S1130-01082013000600003","volume":"105","author":"M Rostami-Nejad","year":"2013","unstructured":"Rostami-Nejad M, Villanacci V, Hogg-Kollars S et al (2013) Endoscopic and histological pitfalls in the diagnosis of celiac disease: a multicentre study assessing the current practice. Rev Esp Enferm Dig 105(6):326\u2013333","journal-title":"Rev Esp Enferm Dig"},{"key":"11044_CR7","doi-asserted-by":"crossref","unstructured":"Karimzadhagh S, Ahmadi B, Olfatifar M et al (2025) Global prevalence of ultra-short coeliac disease (USCD): the first systematic review and meta-analysis. Gut. Mar 20","DOI":"10.1136\/gutjnl-2024-334688"},{"key":"11044_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071006","author":"AM Mazzola","year":"2024","unstructured":"Mazzola AM, Zammarchi I, Valerii MC et al (2024) Gluten-free diet and other Celiac disease therapies: current understanding and emerging strategies. Nutrients. https:\/\/doi.org\/10.3390\/nu16071006","journal-title":"Nutrients"},{"key":"11044_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/foods7060095","author":"A Maggio","year":"2018","unstructured":"Maggio A, Orecchio S (2018) Fatty acid composition of Gluten-Free food (Bakery Products) for Celiac people. Foods. https:\/\/doi.org\/10.3390\/foods7060095","journal-title":"Foods"},{"issue":"1","key":"11044_CR10","doi-asserted-by":"publisher","first-page":"2342619","DOI":"10.1080\/21688370.2024.2342619","volume":"13","author":"S Bakhtiari","year":"2025","unstructured":"Bakhtiari S, Asri N, Jahdkaran M et al (2025) The connection between fatty acids and inflammation in Celiac disease; a deep exploring. Tissue Barriers 13(1):2342619","journal-title":"Tissue Barriers"},{"key":"11044_CR11","doi-asserted-by":"crossref","unstructured":"Santa-Mar\u00eda C, L\u00f3pez-Enr\u00edquez S, Montserrat-de la Paz S et al (2023) Update on Anti-Inflammatory molecular mechanisms induced by oleic acid. Nutrients. ;15(1)","DOI":"10.3390\/nu15010224"},{"issue":"6","key":"11044_CR12","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.bbamem.2014.01.007","volume":"1838","author":"S Lopez","year":"2014","unstructured":"Lopez S, Bermudez B, Montserrat-de la Paz S et al (2014) Membrane composition and dynamics: a target of bioactive Virgin Olive oil constituents. Biochim Biophys Acta 1838(6):1638\u20131656","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"11044_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.158530","volume":"1865","author":"S Ghezzal","year":"2020","unstructured":"Ghezzal S, Postal BG, Quevrain E et al (2020) Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production. Biochimica et Biophysica Acta (BBA) 1865(2):158530","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"11044_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111028","author":"F Ouyang","year":"2022","unstructured":"Ouyang F, Li B, Wang Y et al (2022) Attenuation of palmitic acid-induced intestinal epithelial barrier dysfunction by 6-Shogaol in Caco-2 cells: the role of MiR-216a-5p\/TLR4\/NF-\u03baB axis. Metabolites. https:\/\/doi.org\/10.3390\/metabo12111028","journal-title":"Metabolites"},{"key":"11044_CR15","doi-asserted-by":"crossref","unstructured":"Fedi A, Vitale C, Ponschin G et al (2021) In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review. Journal of Controlled Release. 2021\/07\/10\/;335:247\u2013268","DOI":"10.1016\/j.jconrel.2021.05.028"},{"key":"11044_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2180-14-19","volume":"14","author":"A Orlando","year":"2014","unstructured":"Orlando A, Linsalata M, Notarnicola M et al (2014) Lactobacillus GG restoration of the Gliadin induced epithelial barrier disruption: the role of cellular polyamines. BMC Microbiol 14:19","journal-title":"BMC Microbiol"},{"issue":"1","key":"11044_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/biomethods\/bpab023","volume":"7","author":"A R\u00f6mer","year":"2022","unstructured":"R\u00f6mer A, Rawat D, Linn T, Petry SF (2022) Preparation of fatty acid solutions exerts significant impact on experimental outcomes in cell culture models of lipotoxicity. Biol Methods Protoc 7(1):bpab023","journal-title":"Biol Methods Protoc"},{"key":"11044_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12865-015-0104-1","volume":"16","author":"N Gujral","year":"2015","unstructured":"Gujral N, Suh JW, Sunwoo HH (2015) Effect of anti-gliadin IgY antibody on epithelial intestinal integrity and inflammatory response induced by gliadin. BMC Immunol 16:41","journal-title":"BMC Immunol"},{"issue":"8","key":"11044_CR19","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1021\/acs.jafc.6b05105","volume":"65","author":"L Benoit","year":"2017","unstructured":"Benoit L, Masiri J, Del Blanco IA et al (2017) Assessment of avenins from different oat varieties using R5-based sandwich ELISA. J Agric Food Chem 65(8):1467\u20131472","journal-title":"J Agric Food Chem"},{"issue":"05\/01\/","key":"11044_CR20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jcs.2018.03.012","volume":"2018","author":"KB Gupta","year":"2018","unstructured":"Gupta KB, Upadhyay S, Saini RG et al (2018) Inflammatory response of Gliadin protein isolated from various wheat varieties on human intestinal cell line. J Cereal Sci 2018(05\/01\/):81:91\u201398","journal-title":"J Cereal Sci"},{"issue":"03","key":"11044_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.28982\/josam.7585","volume":"02","author":"C Doguer","year":"2023","unstructured":"Doguer C, Tokatl\u0131 Demirok N, Ege G\u00fcnd\u00fcz KB (2023) Restorative effects of acetobacter ghanensis on the pathogenicity of gliadin-induced modulation of tight junction-associated gene expression in intestinal epithelial cells: impacts of acetobacter ghanensis on the intestinal epithelial barrier. J Surg Med 02(03):7:133\u2013137","journal-title":"J Surg Med"},{"issue":"10","key":"11044_CR22","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.3390\/nu11102325","volume":"11","author":"D Cardoso-Silva","year":"2019","unstructured":"Cardoso-Silva D, Delbue D, Itzlinger A et al (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10):2325","journal-title":"Nutrients"},{"key":"11044_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010172","author":"F Truzzi","year":"2020","unstructured":"Truzzi F, Tibaldi C, Whittaker A et al (2020) Pro-inflammatory effect of gliadins and glutenins extracted from different wheat cultivars on an in vitro 3D intestinal epithelium model. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22010172","journal-title":"Int J Mol Sci"},{"key":"11044_CR24","doi-asserted-by":"crossref","unstructured":"Capozzi A, Vincentini O, Gizzi P et al (2013) Modulatory effect of Gliadin peptide 10-mer on epithelial intestinal CACO-2 cell inflammatory response. PLoS ONE. 06\/18;8:e66561","DOI":"10.1371\/journal.pone.0066561"},{"key":"11044_CR25","doi-asserted-by":"publisher","first-page":"1286667","DOI":"10.3389\/fimmu.2023.1286667","volume":"14","author":"D Yan","year":"2023","unstructured":"Yan D, Ye S, He Y et al (2023) Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment. Front Immunol 14:1286667","journal-title":"Front Immunol"},{"key":"11044_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.604989","volume":"11","author":"AR Basson","year":"2020","unstructured":"Basson AR, Chen C, Sagl F et al (2020) Regulation of intestinal inflammation by dietary fats. Front Immunol 11:604989","journal-title":"Front Immunol"},{"issue":"6","key":"11044_CR27","doi-asserted-by":"publisher","first-page":"e0128218","DOI":"10.1371\/journal.pone.0128218","volume":"10","author":"E Scoditti","year":"2015","unstructured":"Scoditti E, Massaro M, Carluccio MA et al (2015) Additive regulation of adiponectin expression by the Mediterranean diet Olive oil components oleic acid and hydroxytyrosol in human adipocytes. PLoS ONE 10(6):e0128218","journal-title":"PLoS ONE"},{"key":"11044_CR28","doi-asserted-by":"publisher","first-page":"1429591","DOI":"10.3389\/fimmu.2024.1429591","volume":"15","author":"SY Lee","year":"2024","unstructured":"Lee SY, Le DD, Bae CS et al (2024) Oleic acid attenuates asthma pathogenesis via Th1\/Th2 immune cell modulation, TLR3\/4-NF-\u03baB-related inflammation suppression, and intrinsic apoptotic pathway induction. Front Immunol 15:1429591","journal-title":"Front Immunol"},{"key":"11044_CR29","doi-asserted-by":"crossref","unstructured":"Gori M, Altomare A, Cocca S et al (2020) Palmitic acid affects intestinal epithelial barrier integrity and permeability in vitro. Antioxid (Basel). ;9(5)","DOI":"10.3390\/antiox9050417"},{"issue":"11","key":"11044_CR30","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s00011-019-01273-5","volume":"68","author":"J Korbecki","year":"2019","unstructured":"Korbecki J, Bajdak-Rusinek K (2019) The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms. Inflamm Res 68(11):915\u2013932","journal-title":"Inflamm Res"},{"key":"11044_CR31","doi-asserted-by":"publisher","first-page":"984508","DOI":"10.3389\/fimmu.2022.984508","volume":"13","author":"W Fang","year":"2022","unstructured":"Fang W, Liu Y, Chen Q et al (2022) Palmitic acid induces intestinal lipid metabolism disorder, Endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in large yellow croaker Larimichthys crocea. Front Immunol 13:984508","journal-title":"Front Immunol"},{"key":"11044_CR32","doi-asserted-by":"crossref","unstructured":"Bakhtiari S, Asri N, Nikzamir A et al (2024 Dec) Exploring fatty acid effects in Celiac disease: potential therapeutic avenues. Tissue Barriers 3:2435552","DOI":"10.1080\/21688370.2024.2435552"},{"key":"11044_CR33","doi-asserted-by":"crossref","unstructured":"Koelman L, Egea Rodrigues C, Aleksandrova K Effects of dietary patterns on biomarkers of inflammation and immune responses: A systematic review and Meta-Analysis of randomized controlled trials. Advances in nutrition. 2022 2022\/01\/01\/;13(1):101\u2013115","DOI":"10.1093\/advances\/nmab086"},{"issue":"5","key":"11044_CR34","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jand.2022.12.005","volume":"123","author":"M Bonaccio","year":"2023","unstructured":"Bonaccio M, Costanzo S, Di Castelnuovo A et al (2023) Increased adherence to a mediterranean diet is associated with reduced Low-Grade inflammation after a 12.7-Year period: results from the Moli-sani study. J Acad Nutr Diet 123(5):783\u2013795e7","journal-title":"J Acad Nutr Diet"},{"issue":"1","key":"11044_CR35","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/foods10010199","volume":"10","author":"LA Durkin","year":"2021","unstructured":"Durkin LA, Childs CE, Calder PC (2021) Omega-3 polyunsaturated fatty acids and the intestinal epithelium\u2014a review. Foods 10(1):199","journal-title":"Foods"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11044-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11044-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11044-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:03:35Z","timestamp":1766898215000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11044-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["11044"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11044-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"937"}}