{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:52:35Z","timestamp":1793379155476,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1399.183"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1399.183"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1399.183"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1399.183"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1399.183"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1399.183"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1399.183"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1399.183"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.TBZMED.VCR.REC.1399.183"],"award-info":[{"award-number":["IR.TBZMED.VCR.REC.1399.183"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11033-025-11068-z","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:34:20Z","timestamp":1760693660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined effects of 5-azacytidine and oleuropein on miR-149-3p, miR-375, miR-574-5p expression and apoptosis in acute myeloid leukemia (AML) cell lines HL-60 and THP-1"],"prefix":"10.1007","volume":"52","author":[{"given":"Shohre Karimi","family":"Kelaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Najafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Foruzandeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Solali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"11068_CR1","doi-asserted-by":"crossref","unstructured":"Karimi Kelaye S, Najafi F, Kazemi B, Foruzandeh Z, Seif F, Solali S et al (2022) The contributing factors of resistance or sensitivity to epigenetic drugs in the treatment of AML. Clinical and Translational Oncology, vol 24. Springer Science and Business Media Deutschland GmbH, pp 1250\u20131261","DOI":"10.1007\/s12094-022-02776-0"},{"key":"11068_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2026","author":"LF Newell","year":"2021","unstructured":"Newell LF, Cook RJ (2021) Advances in acute myeloid leukemia. BMJ. https:\/\/doi.org\/10.1136\/bmj.n2026","journal-title":"BMJ"},{"key":"11068_CR3","doi-asserted-by":"crossref","unstructured":"Issah MA, Wu D, Zhang F, Zheng W, Liu Y, Fu H et al (2021) Epigenetic modifications in acute myeloid leukemia: the emerging role of circular RNAs (Review). International Journal of Oncology, vol 59. Spandidos","DOI":"10.3892\/ijo.2021.5287"},{"key":"11068_CR4","doi-asserted-by":"crossref","unstructured":"Rishmawi S, Haddad F, Dokmak G, Karaman R (2022) A comprehensive review on the Anti-Cancer effects of Oleuropein, vol 12. Life. MDPI","DOI":"10.3390\/life12081140"},{"issue":"7","key":"11068_CR5","first-page":"505","volume":"25","author":"H Mahi","year":"2023","unstructured":"Mahi H, Yousefi Z, Toufan F, Yarmohammadi M, Jafarisani M, Eskandari N et al (2023) Oleuropein as an effective suppressor of inflammation and MicroRNA-146a expression in patients with rheumatoid arthritis. Cell J 25(7):505\u2013512","journal-title":"Cell J"},{"key":"11068_CR6","doi-asserted-by":"crossref","unstructured":"Chandraprabha Vineetha R, Anitha Geetha Raj J, Devipriya P, Sreelatha Mahitha M, Hariharan S (2024) MicroRNA-based therapies: revolutionizing the treatment of acute myeloid leukemia. International Journal of Laboratory Hematology, vol 46. John Wiley and Sons Inc, pp 33\u201341","DOI":"10.1111\/ijlh.14211"},{"issue":"1","key":"11068_CR7","first-page":"840","volume":"26","author":"Y Tian","year":"2021","unstructured":"Tian Y, Jiang Y, Dong X, Chang Y, Chi J, Chen X (2021) Mir-149-3p suppressed epithelial\u2013mesenchymal transition and tumor development in acute myeloid leukemia. Hematol (United Kingdom) 26(1):840\u2013847","journal-title":"Hematol (United Kingdom)"},{"issue":"1","key":"11068_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4097-z","volume":"18","author":"L Bi","year":"2018","unstructured":"Bi L, Zhou B, Li H, He L, Wang C, Wang Z et al (2018) A novel miR-375-HOXB3-CDCA3\/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia. BMC Cancer 18(1):182","journal-title":"BMC Cancer"},{"key":"11068_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.303","author":"P Djiadeu","year":"2017","unstructured":"Djiadeu P, Azzouz D, Khan MA, Kotra LP, Sweezey N, Palaniyar N (2017) Ultraviolet irradiation increases green fluorescence of Dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation. Pharmacol Res Perspect. https:\/\/doi.org\/10.1002\/prp2.303","journal-title":"Pharmacol Res Perspect"},{"key":"11068_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02993-6","author":"CA S\u00e1nchez-Valdeol\u00edvar","year":"2020","unstructured":"S\u00e1nchez-Valdeol\u00edvar CA, Alvarez-Fitz P, Zacapala-G\u00f3mez AE, Acevedo-Quiroz M, Cayetano-Salazar L, Olea-Flores M (2020) Phytochemical profile and antiproliferative effect of ficus crocata extracts on triple-negative breast cancer cells. BMC Complement Med Ther. https:\/\/doi.org\/10.1186\/s12906-020-02993-6","journal-title":"BMC Complement Med Ther"},{"issue":"2","key":"11068_CR11","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3892\/mmr.2017.6737","volume":"16","author":"X Xiao","year":"2017","unstructured":"Xiao X, Xu Q, Sun Y, Lu Z, Li R, Wang X et al (2017) 5-aza-2\u2032-deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL2-CCR2-ERK signaling pathway. Mol Med Rep 16(2):1417\u20131424","journal-title":"Mol Med Rep"},{"key":"11068_CR12","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2024.2338509","author":"X Wang","year":"2024","unstructured":"Wang X, Xiao Z, Qin T, Xu Z, Jia Y, Qu S et al (2024) Combination therapy with venetoclax and azacitidine for the treatment of myelodysplastic syndromes with DDX41 mutations. Hematology. https:\/\/doi.org\/10.1080\/16078454.2024.2338509","journal-title":"Hematology"},{"key":"11068_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/biof.1366","volume":"43","author":"H Shamshoum","year":"2017","unstructured":"Shamshoum H, Vlavcheski F, Tsiani E, Blackwell Publishing Inc. (2017) Anticancer effects of oleuropein. Biofactors 43:517\u2013528","journal-title":"Biofactors"},{"issue":"6","key":"11068_CR14","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.3892\/mmr.2015.3266","volume":"11","author":"CM Yan","year":"2015","unstructured":"Yan CM, Chai EQ, Cai HY, Miao GY, Ma W (2015) Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase\/protein kinase B pathway in HepG2 human hepatoma cell line. Mol Med Rep 11(6):4617\u20134624","journal-title":"Mol Med Rep"},{"key":"11068_CR15","doi-asserted-by":"crossref","unstructured":"Oleuropein R (2019) Prdx1 Expression, cell proliferation and viability in K562 human leukemia cells. ARC J Cancer Sci. ;5(1)","DOI":"10.20431\/2455-6009.0501004"},{"issue":"9","key":"11068_CR16","doi-asserted-by":"publisher","first-page":"7151","DOI":"10.1002\/jcb.26754","volume":"119","author":"M Abtin","year":"2018","unstructured":"Abtin M, Alivand MR, Khaniani MS, Bastami M, Zaeifizadeh M, Derakhshan SM (2018) Simultaneous downregulation of miR-21 and miR-155 through Oleuropein for breast cancer prevention and therapy. J Cell Biochem 119(9):7151\u20137165","journal-title":"J Cell Biochem"},{"issue":"6","key":"11068_CR17","first-page":"8502","volume":"17","author":"M Lu","year":"2018","unstructured":"Lu M, Xu L, Wang M, Guo T, Luo F, Su N et al (2018) MiR-149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2. Mol Med Rep 17(6):8502\u20138509","journal-title":"Mol Med Rep"},{"issue":"10","key":"11068_CR18","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190061","volume":"9","author":"M Zhang","year":"2019","unstructured":"Zhang M, Gao D, Shi Y, Wang Y, Joshi R, Yu Q et al (2019) Mir-149-3p reverses CD8\u2009+\u2009T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells. Open Biol 9(10):190061","journal-title":"Open Biol"},{"key":"11068_CR19","unstructured":"Yang D, Du G, Xu A, Xi X, Li D (2017) Expression of miR-149-3p inhibits proliferation, migration, and invasion of bladder cancer by targeting S100A4 [Internet]. Vol. 7, Am J Cancer Res. Available from: www.ajcr.us\/ISSN:2156-6976\/ajcr0064090"},{"key":"11068_CR20","doi-asserted-by":"crossref","unstructured":"Yan JW, Lin JS, He XX (2014) The emerging role of miR-375 in cancer. International Journal of Cancer, vol 135. Wiley-Liss Inc., pp 1011\u20131018","DOI":"10.1002\/ijc.28563"},{"key":"11068_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/srep35714","author":"R Zhou","year":"2016","unstructured":"Zhou R, Zhou X, Yin Z, Guo J, Hu T, Jiang S et al (2016) Microrna-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU. Sci Rep. https:\/\/doi.org\/10.1038\/srep35714","journal-title":"Sci Rep"},{"key":"11068_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820971659","author":"Z Lin","year":"2020","unstructured":"Lin Z, Chen M, Wan Y, Lei L, Ruan H (2020) MiR-574-5p targets FOXN3 to regulate the invasion of nasopharyngeal carcinoma cells via Wnt\/\u03b2-catenin pathway. Technol Cancer Res Treat. https:\/\/doi.org\/10.1177\/1533033820971659","journal-title":"Technol Cancer Res Treat"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11068-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11068-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11068-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:05:12Z","timestamp":1766898312000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11068-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["11068"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11068-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7091096\/v1","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Tabriz University of Medical Sciences, Tabriz, Iran.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"1040"}}