{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:17:19Z","timestamp":1761380239140,"version":"build-2065373602"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11188-6","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:13:48Z","timestamp":1761380028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium dynamics unplugged: NCLX in disease and therapeutic frontiers"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-6430","authenticated-orcid":false,"given":"Dhriti","family":"Majumder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"11188_CR1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41580-024-00820-1","volume":"26","author":"B Cartes-Saavedra","year":"2025","unstructured":"Cartes-Saavedra B, Ghosh A, Hajn\u00f3czky G (2025) The roles of mitochondria in global and local intracellular calcium signalling. Nat Rev Mol Cell Biol 26:456\u2013475. https:\/\/doi.org\/10.1038\/s41580-024-00820-1","journal-title":"Nat Rev Mol Cell Biol"},{"key":"11188_CR2","doi-asserted-by":"publisher","first-page":"6181","DOI":"10.1038\/s41467-023-41885-4","volume":"14","author":"J Xue","year":"2023","unstructured":"Xue J, Zeng W, Han Y et al (2023) Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1. Nat Commun 14:6181. https:\/\/doi.org\/10.1038\/s41467-023-41885-4","journal-title":"Nat Commun"},{"key":"11188_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","volume":"552","author":"LD Zorova","year":"2018","unstructured":"Zorova LD, Popkov VA, Plotnikov EY et al (2018) Mitochondrial membrane potential. Anal Biochem 552:50\u201359. https:\/\/doi.org\/10.1016\/j.ab.2017.07.009","journal-title":"Anal Biochem"},{"key":"11188_CR4","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3390\/cells12091273","volume":"12","author":"R Endlicher","year":"2023","unstructured":"Endlicher R, Drahota Z, \u0160tefkov\u00e1 K et al (2023) The mitochondrial permeability transition Pore\u2014Current knowledge of its Structure, Function, and Regulation, and optimized methods for evaluating its functional state. Cells 12:1273. https:\/\/doi.org\/10.3390\/cells12091273","journal-title":"Cells"},{"key":"11188_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2022.11.003","volume":"174","author":"DJ Robichaux","year":"2023","unstructured":"Robichaux DJ, Harata M, Murphy E, Karch J (2023) Mitochondrial permeability transition pore-dependent necrosis. J Mol Cell Cardiol 174:47\u201355. https:\/\/doi.org\/10.1016\/j.yjmcc.2022.11.003","journal-title":"J Mol Cell Cardiol"},{"key":"11188_CR6","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3390\/biom10081200","volume":"10","author":"A Wrzosek","year":"2020","unstructured":"Wrzosek A, Augustynek B, \u017bochowska M, Szewczyk A (2020) Mitochondrial potassium channels as druggable targets. Biomolecules 10:1200. https:\/\/doi.org\/10.3390\/biom10081200","journal-title":"Biomolecules"},{"key":"11188_CR7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.18388\/pb.2018_132","volume":"64","author":"A Szewczyk","year":"2018","unstructured":"Szewczyk A, Bednarczyk P, J\u0119draszko J et al (2018) Mitochondrialne kana\u0142y potasowe: Podsumowanie. Postepy Biochem 64:196\u2013212. https:\/\/doi.org\/10.18388\/pb.2018_132","journal-title":"Postepy Biochem"},{"key":"11188_CR8","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1152\/physrev.00041.2020","volume":"102","author":"JF Garbincius","year":"2022","unstructured":"Garbincius JF, Elrod JW (2022) Mitochondrial calcium exchange in physiology and disease. Physiol Rev 102:893\u2013992. https:\/\/doi.org\/10.1152\/physrev.00041.2020","journal-title":"Physiol Rev"},{"key":"11188_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.semcdb.2019.01.009","volume":"94","author":"M Kostic","year":"2019","unstructured":"Kostic M, Sekler I (2019) Functional properties and mode of regulation of the mitochondrial Na+\/Ca2\u2009+\u2009exchanger, NCLX. Semin Cell Dev Biol 94:59\u201365. https:\/\/doi.org\/10.1016\/j.semcdb.2019.01.009","journal-title":"Semin Cell Dev Biol"},{"key":"11188_CR10","doi-asserted-by":"publisher","first-page":"102345","DOI":"10.1016\/j.ceca.2020.102345","volume":"94","author":"T Katoshevski","year":"2021","unstructured":"Katoshevski T, Ben-Kasus Nissim T, Sekler I (2021) Recent studies on NCLX in health and diseases. Cell Calcium 94:102345. https:\/\/doi.org\/10.1016\/j.ceca.2020.102345","journal-title":"Cell Calcium"},{"key":"11188_CR11","doi-asserted-by":"publisher","first-page":"102416","DOI":"10.1016\/j.ceca.2021.102416","volume":"97","author":"EA Assali","year":"2021","unstructured":"Assali EA, Sekler I (2021) Sprinkling salt on mitochondria: the metabolic and pathophysiological roles of mitochondrial Na\u2009+\u2009signaling mediated by NCLX. Cell Calcium 97:102416. https:\/\/doi.org\/10.1016\/j.ceca.2021.102416","journal-title":"Cell Calcium"},{"key":"11188_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pharmthera.2018.07.001","volume":"192","author":"T Pathak","year":"2018","unstructured":"Pathak T, Trebak M (2018) Mitochondrial Ca2\u2009+\u2009signaling. Pharmacol Ther 192:112\u2013123. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.07.001","journal-title":"Pharmacol Ther"},{"key":"11188_CR13","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.2174\/0113816128264355231121064704","volume":"29","author":"M Kashif","year":"2023","unstructured":"Kashif M, Sivaprakasam P, Vijendra P et al (2023) A recent update on pathophysiology and therapeutic interventions of alzheimer\u2019s disease. Curr Pharm Des 29:3428\u20133441. https:\/\/doi.org\/10.2174\/0113816128264355231121064704","journal-title":"Curr Pharm Des"},{"key":"11188_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","volume":"11","author":"M Verma","year":"2022","unstructured":"Verma M, Lizama BN, Chu CT (2022) Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration. Transl Neurodegener 11:3. https:\/\/doi.org\/10.1186\/s40035-021-00278-7","journal-title":"Transl Neurodegener"},{"key":"11188_CR15","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1074\/jbc.M116.758953","volume":"292","author":"V Sharma","year":"2017","unstructured":"Sharma V, Roy S, Sekler I, O\u2019Halloran DM (2017) The NCLX-type Na+\/Ca2\u2009+\u2009Exchanger NCX-9 is required for patterning of neural circuits in caenorhabditis elegans. J Biol Chem 292:5364\u20135377. https:\/\/doi.org\/10.1074\/jbc.M116.758953","journal-title":"J Biol Chem"},{"key":"11188_CR16","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","volume":"79","author":"MP Blaustein","year":"1999","unstructured":"Blaustein MP, Lederer WJ (1999) Sodium\/Calcium exchange: its physiological implications. Physiol Rev 79:763\u2013854. https:\/\/doi.org\/10.1152\/physrev.1999.79.3.763","journal-title":"Physiol Rev"},{"key":"11188_CR17","doi-asserted-by":"crossref","unstructured":"Albers RW, Siegel GJ, Xie Z-J (2012) Membrane transport. Basic neurochemistry. Elsevier, pp 40\u201362","DOI":"10.1016\/B978-0-12-374947-5.00003-1"},{"key":"11188_CR18","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1016\/j.celrep.2018.11.084","volume":"25","author":"M Kostic","year":"2018","unstructured":"Kostic M, Katoshevski T, Sekler I (2018) Allosteric regulation of NCLX by mitochondrial membrane potential links the metabolic state and Ca2\u2009+\u2009Signaling in mitochondria. Cell Rep 25:3465\u20133475e4. https:\/\/doi.org\/10.1016\/j.celrep.2018.11.084","journal-title":"Cell Rep"},{"key":"11188_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11427-014-4789-9","volume":"58","author":"LI Nita","year":"2015","unstructured":"Nita LI, Hershfinkel M, Sekler I (2015) Life after the birth of the mitochondrial Na+\/Ca2\u2009+\u2009exchanger, NCLX. Sci China Life Sci 58:59\u201365. https:\/\/doi.org\/10.1007\/s11427-014-4789-9","journal-title":"Sci China Life Sci"},{"key":"11188_CR20","doi-asserted-by":"publisher","first-page":"106296","DOI":"10.1016\/j.isci.2023.106296","volume":"26","author":"P Jadiya","year":"2023","unstructured":"Jadiya P, Cohen HM, Kolmetzky DW et al (2023) Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline. iScience 26:106296. https:\/\/doi.org\/10.1016\/j.isci.2023.106296","journal-title":"iScience"},{"key":"11188_CR21","doi-asserted-by":"publisher","unstructured":"Pathak T, Gueguinou M, Walter V et al (2020) Dichotomous role of the human mitochondrial Na+\/Ca2+\/Li\u2009+\u2009exchanger NCLX in colorectal cancer growth and metastasis. Elife 9. https:\/\/doi.org\/10.7554\/eLife.59686","DOI":"10.7554\/eLife.59686"},{"key":"11188_CR22","doi-asserted-by":"publisher","first-page":"e23454","DOI":"10.1096\/fj.202301368RR","volume":"38","author":"VM Ramos","year":"2024","unstructured":"Ramos VM, Serna JDC, Vilas-Boas EA et al (2024) Mitochondrial sodium\/calcium exchanger (NCLX) regulates basal and starvation-induced autophagy through calcium signaling. FASEB J 38:e23454. https:\/\/doi.org\/10.1096\/fj.202301368RR","journal-title":"FASEB J"},{"key":"11188_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.yjmcc.2014.10.019","volume":"78","author":"GSB Williams","year":"2015","unstructured":"Williams GSB, Boyman L, Lederer WJ (2015) Mitochondrial calcium and the regulation of metabolism in the heart. J Mol Cell Cardiol 78:35\u201345. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.10.019","journal-title":"J Mol Cell Cardiol"},{"key":"11188_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00395-023-01029-7","volume":"119","author":"G Li","year":"2024","unstructured":"Li G, Huang H, Wu Y et al (2024) Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes. Basic Res Cardiol 119:151\u2013168. https:\/\/doi.org\/10.1007\/s00395-023-01029-7","journal-title":"Basic Res Cardiol"},{"key":"11188_CR25","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.yjmcc.2020.11.014","volume":"151","author":"B O\u2019Rourke","year":"2021","unstructured":"O\u2019Rourke B, Ashok D, Liu T (2021) Mitochondrial Ca2\u2009+\u2009in heart failure: not enough or too much? J Mol Cell Cardiol 151:126\u2013134. https:\/\/doi.org\/10.1016\/j.yjmcc.2020.11.014","journal-title":"J Mol Cell Cardiol"},{"key":"11188_CR26","doi-asserted-by":"publisher","unstructured":"Takeuchi A, Matsuoka S (2022) Spatial and functional crosstalk between the mitochondrial Na+-Ca2\u2009+\u2009Exchanger NCLX and the sarcoplasmic reticulum Ca2\u2009+\u2009Pump SERCA in cardiomyocytes. Int J Mol Sci 23. https:\/\/doi.org\/10.3390\/ijms23147948","DOI":"10.3390\/ijms23147948"},{"key":"11188_CR27","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.yjmcc.2011.08.003","volume":"51","author":"AC Chikando","year":"2011","unstructured":"Chikando AC, Kettlewell S, Williams GS et al (2011) Ca2\u2009+\u2009dynamics in the mitochondria - state of the Art. J Mol Cell Cardiol 51:627\u2013631. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.08.003","journal-title":"J Mol Cell Cardiol"},{"key":"11188_CR28","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.bbadis.2017.12.005","volume":"1864","author":"R Purroy","year":"2018","unstructured":"Purroy R, Britti E, Delaspre F et al (2018) Mitochondrial pore opening and loss of Ca2\u2009+\u2009exchanger NCLX levels occur after frataxin depletion. Biochim Biophys Acta Mol Basis Dis 1864:618\u2013631. https:\/\/doi.org\/10.1016\/j.bbadis.2017.12.005","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"11188_CR29","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00424-018-2123-2","volume":"470","author":"C Mammucari","year":"2018","unstructured":"Mammucari C, Raffaello A, Vecellio Reane D et al (2018) Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models. Pflugers Arch 470:1165\u20131179. https:\/\/doi.org\/10.1007\/s00424-018-2123-2","journal-title":"Pflugers Arch"},{"key":"11188_CR30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1161\/CIRCRESAHA.120.318239","volume":"128","author":"M P\u00e9rez-Hern\u00e1ndez","year":"2021","unstructured":"P\u00e9rez-Hern\u00e1ndez M, Leo-Macias A, Keegan S et al (2021) Structural and functional characterization of a Nav1.5-Mitochondrial Couplon. Circ Res 128:419\u2013432. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.318239","journal-title":"Circ Res"},{"key":"11188_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-1-4614-4756-6_16","volume":"961","author":"B Kim","year":"2013","unstructured":"Kim B, Takeuchi A, Koga O et al (2013) Mitochondria Na(+)-Ca (2+) exchange in cardiomyocytes and lymphocytes. Adv Exp Med Biol 961:193\u2013201. https:\/\/doi.org\/10.1007\/978-1-4614-4756-6_16","journal-title":"Adv Exp Med Biol"},{"key":"11188_CR32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/ehjacc\/zuad138","volume":"13","author":"CE Goldfine","year":"2024","unstructured":"Goldfine CE, Troger A, Erickson TB, Chai PR (2024) Beta-blocker and calcium-channel blocker toxicity: current evidence on evaluation and management. Eur Heart J Acute Cardiovasc Care 13:247\u2013253. https:\/\/doi.org\/10.1093\/ehjacc\/zuad138","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"11188_CR33","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.amjmed.2019.01.039","volume":"132","author":"E Argulian","year":"2019","unstructured":"Argulian E, Bangalore S, Messerli FH (2019) Misconceptions and facts about Beta-Blockers. Am J Med 132:816\u2013819. https:\/\/doi.org\/10.1016\/j.amjmed.2019.01.039","journal-title":"Am J Med"},{"key":"11188_CR34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1080\/17425255.2020.1803279","volume":"16","author":"CD Thomas","year":"2020","unstructured":"Thomas CD, Johnson JA (2020) Pharmacogenetic factors affecting \u03b2-blocker metabolism and response. Expert Opin Drug Metab Toxicol 16:953\u2013964. https:\/\/doi.org\/10.1080\/17425255.2020.1803279","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"11188_CR35","doi-asserted-by":"publisher","first-page":"4760","DOI":"10.1038\/s41598-022-08534-0","volume":"12","author":"A Sorrentino","year":"2022","unstructured":"Sorrentino A, Bagwan N, Linscheid N et al (2022) Beta-blocker\/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts. Sci Rep 12:4760. https:\/\/doi.org\/10.1038\/s41598-022-08534-0","journal-title":"Sci Rep"},{"key":"11188_CR36","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1016\/j.jacc.2018.01.058","volume":"71","author":"FH Messerli","year":"2018","unstructured":"Messerli FH, Bangalore S, Bavishi C, Rimoldi SF (2018) Angiotensin-Converting enzyme inhibitors in hypertension: to use or not to use? J Am Coll Cardiol 71:1474\u20131482. https:\/\/doi.org\/10.1016\/j.jacc.2018.01.058","journal-title":"J Am Coll Cardiol"},{"key":"11188_CR37","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1177\/1060028018779082","volume":"52","author":"A Helmer","year":"2018","unstructured":"Helmer A, Slater N, Smithgall S (2018) A review of ACE inhibitors and ARBs in black patients with hypertension. Ann Pharmacother 52:1143\u20131151. https:\/\/doi.org\/10.1177\/1060028018779082","journal-title":"Ann Pharmacother"},{"key":"11188_CR38","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1017\/s0317167100016735","volume":"41","author":"H Jalal","year":"2014","unstructured":"Jalal H, Ganesh A, Lau R et al (2014) Cholinesterase-inhibitor associated mania: A case report and literature review. Can J Neurol Sci 41:278\u2013280. https:\/\/doi.org\/10.1017\/s0317167100016735","journal-title":"Can J Neurol Sci"},{"key":"11188_CR39","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1345\/aph.1Q445","volume":"46","author":"CL McDermott","year":"2012","unstructured":"McDermott CL, Gray SL (2012) Cholinesterase inhibitor adjunctive therapy for cognitive impairment and depressive symptoms in older adults with depression. Ann Pharmacother 46:599\u2013605. https:\/\/doi.org\/10.1345\/aph.1Q445","journal-title":"Ann Pharmacother"},{"key":"11188_CR40","doi-asserted-by":"publisher","unstructured":"Giacobini E (2000) Cholinesterase inhibitor therapy stabilizes symptoms of alzheimer disease. Alzheimer Dis Assoc Disord 14(Suppl 1). https:\/\/doi.org\/10.1097\/00002093-200000001-00002. :S3-10","DOI":"10.1097\/00002093-200000001-00002"},{"key":"11188_CR41","doi-asserted-by":"publisher","unstructured":"Fahn S (2008) The history of dopamine and Levodopa in the treatment of parkinson\u2019s disease. Mov Disord 23 Suppl 3S497\u2013508. https:\/\/doi.org\/10.1002\/mds.22028","DOI":"10.1002\/mds.22028"},{"key":"11188_CR42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3233\/JPD-225060","volume":"13","author":"W Pirker","year":"2023","unstructured":"Pirker W, Katzenschlager R, Hallett M, Poewe W (2023) Pharmacological treatment of tremor in parkinson\u2019s disease revisited. J Parkinsons Dis 13:127\u2013144. https:\/\/doi.org\/10.3233\/JPD-225060","journal-title":"J Parkinsons Dis"},{"key":"11188_CR43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/mds.26082","volume":"30","author":"PA LeWitt","year":"2015","unstructured":"LeWitt PA (2015) Levodopa therapy for parkinson\u2019s disease: pharmacokinetics and pharmacodynamics. Mov Disord 30:64\u201372. https:\/\/doi.org\/10.1002\/mds.26082","journal-title":"Mov Disord"},{"key":"11188_CR44","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1001\/jama.2023.18589","volume":"330","author":"DS Feig","year":"2023","unstructured":"Feig DS (2023) Metformin for diabetes in pregnancy: are we closer to defining its role? JAMA 330:2167\u20132169. https:\/\/doi.org\/10.1001\/jama.2023.18589","journal-title":"JAMA"},{"key":"11188_CR45","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1001\/jama.2023.22949","volume":"330","author":"KA Boggess","year":"2023","unstructured":"Boggess KA, Valint A, Refuerzo JS et al (2023) Metformin plus insulin for preexisting diabetes or gestational diabetes in early pregnancy: the MOMPOD randomized clinical trial. JAMA 330:2182\u20132190. https:\/\/doi.org\/10.1001\/jama.2023.22949","journal-title":"JAMA"},{"key":"11188_CR46","doi-asserted-by":"publisher","unstructured":"Halada S, Casado-Medrano V, Baran JA et al (2022) Hormonal crosstalk between thyroid and breast cancer. https:\/\/doi.org\/10.1210\/endocr\/bqac075. Endocrinology 163:","DOI":"10.1210\/endocr\/bqac075"},{"key":"11188_CR47","doi-asserted-by":"publisher","first-page":"172783","DOI":"10.1016\/j.ejphar.2019.172783","volume":"866","author":"S Student","year":"2020","unstructured":"Student S, Hejmo T, Potera\u0142a-Hejmo A et al (2020) Anti-androgen hormonal therapy for cancer and other diseases. Eur J Pharmacol 866:172783. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172783","journal-title":"Eur J Pharmacol"},{"key":"11188_CR48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.21614\/chirurgia.112.4.413","volume":"112","author":"M Dr\u0103g\u0103nescu","year":"2017","unstructured":"Dr\u0103g\u0103nescu M, Carmocan C (2017) Hormone therapy in breast cancer. Chirurgia (Bucur) 112:413\u2013417. https:\/\/doi.org\/10.21614\/chirurgia.112.4.413","journal-title":"Chirurgia (Bucur)"},{"key":"11188_CR49","doi-asserted-by":"publisher","first-page":"eabo0789","DOI":"10.1126\/sciadv.abo0789","volume":"8","author":"X-W Zhang","year":"2022","unstructured":"Zhang X-W, Feng N, Liu Y-C et al (2022) Neuroinflammation Inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv 8:eabo0789. https:\/\/doi.org\/10.1126\/sciadv.abo0789","journal-title":"Sci Adv"},{"key":"11188_CR50","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","volume":"133","author":"TM Seibt","year":"2019","unstructured":"Seibt TM, Proneth B, Conrad M (2019) Role of GPX4 in ferroptosis and its Pharmacological implication. Free Radic Biol Med 133:144\u2013152. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.09.014","journal-title":"Free Radic Biol Med"},{"key":"11188_CR51","doi-asserted-by":"publisher","first-page":"113749","DOI":"10.1016\/j.ejmech.2021.113749","volume":"225","author":"C Wang","year":"2021","unstructured":"Wang C, Zhang Y, Wu Y, Xing D (2021) Developments of CRBN-based protacs as potential therapeutic agents. Eur J Med Chem 225:113749. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113749","journal-title":"Eur J Med Chem"},{"key":"11188_CR52","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature12656","volume":"503","author":"M Okada-Iwabu","year":"2013","unstructured":"Okada-Iwabu M, Yamauchi T, Iwabu M et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503:493\u2013499. https:\/\/doi.org\/10.1038\/nature12656","journal-title":"Nature"},{"key":"11188_CR53","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1161\/ATVBAHA.119.310961","volume":"39","author":"AM Schmidt","year":"2019","unstructured":"Schmidt AM (2019) Diabetes mellitus and cardiovascular disease. Arterioscler Thromb Vasc Biol 39:558\u2013568. https:\/\/doi.org\/10.1161\/ATVBAHA.119.310961","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"11188_CR54","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/jnc.15745","volume":"165","author":"JV Cabral-Costa","year":"2023","unstructured":"Cabral-Costa JV, Vicente\u2010Guti\u00e9rrez C, Agulla J et al (2023) Mitochondrial sodium\/calcium exchanger\u2009<\u2009scp\u2009>\u2009NCLX\u2009regulates Glycolysis in astrocytes, impacting on cognitive performance. J Neurochem 165:521\u2013535. https:\/\/doi.org\/10.1111\/jnc.15745","journal-title":"J Neurochem"},{"key":"11188_CR55","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1139\/cjpp-2016-0512","volume":"95","author":"I Ahmet","year":"2017","unstructured":"Ahmet I, Tae H-J, Lakatta EG, Talan M (2017) Long-term low dose dietary Resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats. Can J Physiol Pharmacol 95:268\u2013274. https:\/\/doi.org\/10.1139\/cjpp-2016-0512","journal-title":"Can J Physiol Pharmacol"},{"key":"11188_CR56","doi-asserted-by":"publisher","unstructured":"Marrache S, Dhar S (2012) Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proceedings of the National Academy of Sciences 109:16288\u201316293. https:\/\/doi.org\/10.1073\/pnas.1210096109","DOI":"10.1073\/pnas.1210096109"},{"key":"11188_CR57","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.7150\/ijbs.39508","volume":"16","author":"Z Meng","year":"2020","unstructured":"Meng Z, Yu Y, Zhang Y et al (2020) Highly bioavailable Berberine formulation improves glucocorticoid receptor-mediated insulin resistance via reduction in association of the glucocorticoid receptor with phosphatidylinositol-3-kinase. Int J Biol Sci 16:2527\u20132541. https:\/\/doi.org\/10.7150\/ijbs.39508","journal-title":"Int J Biol Sci"},{"key":"11188_CR58","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s40199-019-00255-6","volume":"27","author":"V Oveissi","year":"2019","unstructured":"Oveissi V, Ram M, Bahramsoltani R et al (2019) Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective. Daru 27:389\u2013406. https:\/\/doi.org\/10.1007\/s40199-019-00255-6","journal-title":"Daru"},{"key":"11188_CR59","doi-asserted-by":"publisher","first-page":"1290023","DOI":"10.3389\/fphar.2023.1290023","volume":"14","author":"L Ao","year":"2023","unstructured":"Ao L, Chen Z, Yin J et al (2023) Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating Endoplasmic reticulum stress. Front Pharmacol 14:1290023. https:\/\/doi.org\/10.3389\/fphar.2023.1290023","journal-title":"Front Pharmacol"},{"key":"11188_CR60","doi-asserted-by":"publisher","first-page":"106596","DOI":"10.1016\/j.compbiomed.2023.106596","volume":"155","author":"M Wahid","year":"2023","unstructured":"Wahid M, Saqib F, Akhtar S et al (2023) Mechanistic insights of cucumis Melo L. seeds for Gastrointestinal muscle spasms through calcium signaling pathway-related gene regulation networks in WGCNA and in vitro, in vivo studies. Comput Biol Med 155:106596. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.106596","journal-title":"Comput Biol Med"},{"key":"11188_CR61","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1080\/01635581.2021.2020305","volume":"74","author":"X Li","year":"2022","unstructured":"Li X, Miao S, Li F et al (2022) Cellular calcium signals in cancer chemoprevention and chemotherapy by phytochemicals. Nutr Cancer 74:2671\u20132685. https:\/\/doi.org\/10.1080\/01635581.2021.2020305","journal-title":"Nutr Cancer"},{"key":"11188_CR62","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1871527320666210212141232","volume":"21","author":"A Ludhiadch","year":"2022","unstructured":"Ludhiadch A, Sharma R, Muriki A, Munshi A (2022) Role of calcium homeostasis in ischemic stroke: A review. CNS Neurol Disord Drug Targets 21:52\u201361. https:\/\/doi.org\/10.2174\/1871527320666210212141232","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"11188_CR63","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ceca.2016.03.004","volume":"60","author":"K Kiselyov","year":"2016","unstructured":"Kiselyov K, Muallem S (2016) ROS and intracellular ion channels. Cell Calcium 60:108\u2013114. https:\/\/doi.org\/10.1016\/j.ceca.2016.03.004","journal-title":"Cell Calcium"},{"key":"11188_CR64","doi-asserted-by":"publisher","first-page":"122651","DOI":"10.1016\/j.lfs.2024.122651","volume":"347","author":"V Rahi","year":"2024","unstructured":"Rahi V, Kaundal RK (2024) Exploring the intricacies of calcium dysregulation in ischemic stroke: insights into neuronal cell death and therapeutic strategies. Life Sci 347:122651. https:\/\/doi.org\/10.1016\/j.lfs.2024.122651","journal-title":"Life Sci"},{"key":"11188_CR65","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00014.2024","volume":"39","author":"E Balderas","year":"2024","unstructured":"Balderas E, Lee SHJ, Rai NK (2024) Mitochondrial calcium regulation of cardiac metabolism in health and disease. Physiology 39:0. https:\/\/doi.org\/10.1152\/physiol.00014.2024","journal-title":"Physiology"},{"key":"11188_CR66","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3389\/fnins.2018.00523","volume":"12","author":"M Verma","year":"2018","unstructured":"Verma M, Wills Z, Chu CT (2018) Excitatory dendritic mitochondrial calcium toxicity: implications for parkinson\u2019s and other neurodegenerative diseases. Front Neurosci 12:523. https:\/\/doi.org\/10.3389\/fnins.2018.00523","journal-title":"Front Neurosci"},{"key":"11188_CR67","doi-asserted-by":"publisher","first-page":"1202167","DOI":"10.3389\/fnins.2023.1202167","volume":"17","author":"GA Johnson","year":"2023","unstructured":"Johnson GA, Krishnamoorthy RR, Stankowska DL (2023) Modulating mitochondrial calcium channels (TRPM2\/MCU\/NCX) as a therapeutic strategy for neurodegenerative disorders. Front Neurosci 17:1202167. https:\/\/doi.org\/10.3389\/fnins.2023.1202167","journal-title":"Front Neurosci"},{"key":"11188_CR68","doi-asserted-by":"publisher","unstructured":"Weinberg Sibony R, Segev O, Dor S, Raz I (2023) Drug therapies for diabetes. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/ijms242417147","DOI":"10.3390\/ijms242417147"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11188-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11188-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11188-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:13:49Z","timestamp":1761380029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11188-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11188"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11188-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"25 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This review article does not involve any human participants or animal studies. Therefore, no ethical approval was required. The authors declare no conflicts of interest related to this work. Additionally, there are no funding interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}],"article-number":"12"}}