{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:55:35Z","timestamp":1792032935365,"version":"4.4.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11248-x","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:20:20Z","timestamp":1763554820000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["METTL3 in colorectal cancer: molecular insights and clinical implications"],"prefix":"10.1007","volume":"53","author":[{"given":"Francisco Alejandro","family":"Lagunas-Rangel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"11248_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2022.151916","volume":"124","author":"G Li","year":"2022","unstructured":"Li G, Sun Z, Deng W et al (2022) METTL3 plays a crucial function in multiple biological processes. Acta Histochem 124:151916. https:\/\/doi.org\/10.1016\/j.acthis.2022.151916","journal-title":"Acta Histochem"},{"key":"11248_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00951-w","volume":"13","author":"C Zeng","year":"2020","unstructured":"Zeng C, Huang W, Li Y, Weng H (2020) Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol 13:117. https:\/\/doi.org\/10.1186\/s13045-020-00951-w","journal-title":"J Hematol Oncol"},{"key":"11248_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch-Moshkovitz S, Schwartz S et al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201\u2013206. https:\/\/doi.org\/10.1038\/nature11112","journal-title":"Nature"},{"key":"11248_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/15476286.2024.2429945","volume":"21","author":"FA Lagunas-Rangel","year":"2024","unstructured":"Lagunas-Rangel FA (2024) Role of circular RNAs in DNA repair. RNA Biol 21:149\u2013161. https:\/\/doi.org\/10.1080\/15476286.2024.2429945","journal-title":"RNA Biol"},{"key":"11248_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01360-5","volume":"21","author":"Q Jin","year":"2023","unstructured":"Jin Q, Qu H, Quan C (2023) New insights into the regulation of METTL3 and its role in tumors. Cell Commun Signal 21:334. https:\/\/doi.org\/10.1186\/s12964-023-01360-5","journal-title":"Cell Commun Signal"},{"key":"11248_CR6","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.1007\/s00432-022-04429-9","volume":"149","author":"L Huang","year":"2023","unstructured":"Huang L, Liang D, Zhang Y et al (2023) METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b. J Cancer Res Clin Oncol 149:5095\u20135108. https:\/\/doi.org\/10.1007\/s00432-022-04429-9","journal-title":"J Cancer Res Clin Oncol"},{"key":"11248_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034658","volume":"102","author":"H Li","year":"2023","unstructured":"Li H, Liu Z, Wang H (2023) Expression and clinical significance of METTL3 in colorectal cancer. Medicine (Baltimore) 102:e34658. https:\/\/doi.org\/10.1097\/MD.0000000000034658","journal-title":"Medicine (Baltimore)"},{"key":"11248_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbrc.2022.04.141","volume":"614","author":"T Yu","year":"2022","unstructured":"Yu T, Liu J, Wang Y et al (2022) METTL3 promotes colorectal cancer metastasis by stabilizing PLAU mRNA in an m6A-dependent manner. Biochem Biophys Res Commun 614:9\u201316. https:\/\/doi.org\/10.1016\/j.bbrc.2022.04.141","journal-title":"Biochem Biophys Res Commun"},{"key":"11248_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04950-2","volume":"13","author":"X Liu","year":"2022","unstructured":"Liu X, He H, Zhang F et al (2022) M6A methylated EphA2 and VEGFA through IGF2BP2\/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K\/AKT and ERK1\/2 signaling. Cell Death Dis 13:483. https:\/\/doi.org\/10.1038\/s41419-022-04950-2","journal-title":"Cell Death Dis"},{"key":"11248_CR10","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12972","volume":"22","author":"J Wen","year":"2021","unstructured":"Wen J, Zhang G, Meng Y et al (2021) RNA m 6 a methyltransferase METTL3 promotes colorectal cancer cell proliferation and invasion by regulating snail expression. Oncol Lett 22:711. https:\/\/doi.org\/10.3892\/ol.2021.12972","journal-title":"Oncol Lett"},{"key":"11248_CR11","first-page":"1789","volume":"12","author":"S Xiang","year":"2020","unstructured":"Xiang S, Liang X, Yin S et al (2020) N6-methyladenosine methyltransferase METTL3 promotes colorectal cancer cell proliferation through enhancing MYC expression. Am J Transl Res 12:1789\u20131806","journal-title":"Am J Transl Res"},{"key":"11248_CR12","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1002\/1878-0261.12898","volume":"15","author":"D Zhou","year":"2021","unstructured":"Zhou D, Tang W, Xu Y et al (2021) METTL3\/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5. Mol Oncol 15:2172\u20132184. https:\/\/doi.org\/10.1002\/1878-0261.12898","journal-title":"Mol Oncol"},{"key":"11248_CR13","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13104","volume":"28","author":"Y Xu","year":"2023","unstructured":"Xu Y, Bao Y, Qiu G et al (2023) METTL3 promotes proliferation and migration of colorectal cancer cells by increasing SNHG1 stability. Mol Med Rep 28:217. https:\/\/doi.org\/10.3892\/mmr.2023.13104","journal-title":"Mol Med Rep"},{"key":"11248_CR14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18434","author":"P \u015aled\u017a","year":"2016","unstructured":"\u015aled\u017a P, Jinek M (2016) Structural insights into the molecular mechanism of the m6A writer complex. Elife. https:\/\/doi.org\/10.7554\/eLife.18434","journal-title":"Elife"},{"key":"11248_CR15","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","volume":"62","author":"S Lin","year":"2016","unstructured":"Lin S, Choe J, Du P et al (2016) The m 6 A methyltransferase METTL3 promotes translation in human cancer cells. Mol Cell 62:335\u2013345. https:\/\/doi.org\/10.1016\/j.molcel.2016.03.021","journal-title":"Mol Cell"},{"key":"11248_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s13238-018-0518-7","volume":"10","author":"J Huang","year":"2019","unstructured":"Huang J, Dong X, Gong Z et al (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell 10:272\u2013284. https:\/\/doi.org\/10.1007\/s13238-018-0518-7","journal-title":"Protein Cell"},{"key":"11248_CR17","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","volume":"63","author":"P Wang","year":"2016","unstructured":"Wang P, Doxtader KA, Nam Y (2016) Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases. Mol Cell 63:306\u2013317. https:\/\/doi.org\/10.1016\/j.molcel.2016.05.041","journal-title":"Mol Cell"},{"key":"11248_CR18","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature18298","volume":"534","author":"X Wang","year":"2016","unstructured":"Wang X, Feng J, Xue Y et al (2016) Structural basis of N6-adenosine methylation by the METTL3\u2013METTL14 complex. Nature 534:575\u2013578. https:\/\/doi.org\/10.1038\/nature18298","journal-title":"Nature"},{"key":"11248_CR19","doi-asserted-by":"publisher","first-page":"4493","DOI":"10.1021\/ac9004309","volume":"81","author":"S Gauci","year":"2009","unstructured":"Gauci S, Helbig AO, Slijper M et al (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81:4493\u20134501. https:\/\/doi.org\/10.1021\/ac9004309","journal-title":"Anal Chem"},{"issue":"4","key":"11248_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1261\/rna.064063.117","volume":"24","author":"E Sch\u00f6ller","year":"2018","unstructured":"Sch\u00f6ller E, Weichmann F, Treiber T et al (2018) Interactions, localization, and phosphorylation of the m 6 A generating METTL3\u2013METTL14\u2013WTAP complex. RNA 24(4):499\u2013512. https:\/\/doi.org\/10.1261\/rna.064063.117","journal-title":"RNA"},{"key":"11248_CR21","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.1093\/nar\/gky156","volume":"46","author":"Y Du","year":"2018","unstructured":"Du Y, Hou G, Zhang H et al (2018) SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. Nucleic Acids Res 46:5195\u20135208. https:\/\/doi.org\/10.1093\/nar\/gky156","journal-title":"Nucleic Acids Res"},{"key":"11248_CR22","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/j.molcel.2022.02.033","volume":"82","author":"J Xiong","year":"2022","unstructured":"Xiong J, He J, Zhu J et al (2022) Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells. Mol Cell 82:1660-1677e10. https:\/\/doi.org\/10.1016\/j.molcel.2022.02.033","journal-title":"Mol Cell"},{"key":"11248_CR23","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.molcel.2025.02.016","volume":"85","author":"X Huang","year":"2025","unstructured":"Huang X, Zhang J, Cun Y et al (2025) Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin. Mol Cell 85:1349\u20131365e10. https:\/\/doi.org\/10.1016\/j.molcel.2025.02.016","journal-title":"Mol Cell"},{"key":"11248_CR24","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.molcel.2020.10.026","volume":"80","author":"H-L Sun","year":"2020","unstructured":"Sun H-L, Zhu AC, Gao Y et al (2020) Stabilization of ERK-phosphorylated METTL3 by USP5 increases m6A methylation. Mol Cell 80:633-647e7. https:\/\/doi.org\/10.1016\/j.molcel.2020.10.026","journal-title":"Mol Cell"},{"key":"11248_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1015293","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, Gao S, Liang X et al (2021) Inhibiting PP2Ac \u03b1 promotes the malignant phenotype of gastric cancer cells through the ATM\/METTL3 axis. Biomed Res Int. https:\/\/doi.org\/10.1155\/2021\/1015293","journal-title":"Biomed Res Int"},{"key":"11248_CR26","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.7150\/thno.42539","volume":"10","author":"H Xu","year":"2020","unstructured":"Xu H, Wang H, Zhao W et al (2020) SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating snail mRNA homeostasis in hepatocellular carcinoma. Theranostics 10:5671\u20135686. https:\/\/doi.org\/10.7150\/thno.42539","journal-title":"Theranostics"},{"key":"11248_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0019-0","volume":"4","author":"Y Yue","year":"2018","unstructured":"Yue Y, Liu J, Cui X et al (2018) VIRMA mediates preferential m6A mRNA methylation in 3\u2032UTR and near stop codon and associates with alternative polyadenylation. Cell Discov 4:10. https:\/\/doi.org\/10.1038\/s41421-018-0019-0","journal-title":"Cell Discov"},{"key":"11248_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","volume":"537","author":"DP Patil","year":"2016","unstructured":"Patil DP, Chen C-K, Pickering BF et al (2016) M6A RNA methylation promotes XIST-mediated transcriptional repression. Nature 537:369\u2013373. https:\/\/doi.org\/10.1038\/nature19342","journal-title":"Nature"},{"key":"11248_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03035-6","volume":"43","author":"P Ouyang","year":"2024","unstructured":"Ouyang P, Li K, Xu W et al (2024) METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis. J Exp Clin Cancer Res 43:111. https:\/\/doi.org\/10.1186\/s13046-024-03035-6","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"11248_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12943-019-1038-7","volume":"18","author":"T Li","year":"2019","unstructured":"Li T, Hu PS, Zuo Z et al (2019) METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma. Mol Cancer. https:\/\/doi.org\/10.1186\/s12943-019-1038-7","journal-title":"Mol Cancer"},{"key":"11248_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1408-4","volume":"38","author":"W Peng","year":"2019","unstructured":"Peng W, Li J, Chen R et al (2019) Upregulated METTL3 promotes metastasis of colorectal cancer via miR-1246\/SPRED2\/MAPK signaling pathway. J Exp Clin Cancer Res 38:393. https:\/\/doi.org\/10.1186\/s13046-019-1408-4","journal-title":"J Exp Clin Cancer Res"},{"key":"11248_CR32","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.2147\/OTT.S201052","volume":"12","author":"R Deng","year":"2019","unstructured":"Deng R, Cheng Y, Ye S et al (2019) M6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38\/ERK pathways. Onco Targets Ther 12:4391\u20134402. https:\/\/doi.org\/10.2147\/OTT.S201052","journal-title":"Onco Targets Ther"},{"key":"11248_CR33","doi-asserted-by":"publisher","DOI":"10.1515\/med-2025-1167","author":"M Naveed","year":"2025","unstructured":"Naveed M, Mughal MS, Aziz T et al (2025) Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development. Open Med. https:\/\/doi.org\/10.1515\/med-2025-1167","journal-title":"Open Med"},{"key":"11248_CR34","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1111\/jcmm.15042","volume":"24","author":"W Zhu","year":"2020","unstructured":"Zhu W, Si Y, Xu J et al (2020) Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A-dependent manner. J Cell Mol Med 24:3521\u20133533. https:\/\/doi.org\/10.1111\/jcmm.15042","journal-title":"J Cell Mol Med"},{"key":"11248_CR35","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/s41388-024-02956-y","volume":"43","author":"Z Chen","year":"2024","unstructured":"Chen Z, Zhou J, Wu Y et al (2024) METTL3 promotes cellular senescence of colorectal cancer via modulation of CDKN2B transcription and mRNA stability. Oncogene 43:976\u2013991. https:\/\/doi.org\/10.1038\/s41388-024-02956-y","journal-title":"Oncogene"},{"key":"11248_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44379-x","volume":"13","author":"J Yi","year":"2023","unstructured":"Yi J, Peng F, Zhao J, Gong X (2023) METTL3\/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3. Sci Rep 13:17292. https:\/\/doi.org\/10.1038\/s41598-023-44379-x","journal-title":"Sci Rep"},{"key":"11248_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03399-3","volume":"20","author":"X Wang","year":"2022","unstructured":"Wang X, Lu X, Wang P et al (2022) SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. J Transl Med 20:198. https:\/\/doi.org\/10.1186\/s12967-022-03399-3","journal-title":"J Transl Med"},{"key":"11248_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105177","volume":"299","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wan X, Yang X et al (2023) eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation. J Biol Chem 299:105177. https:\/\/doi.org\/10.1016\/j.jbc.2023.105177","journal-title":"J Biol Chem"},{"key":"11248_CR39","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.26355\/eurrev_202303_31793","volume":"27","author":"J Oh","year":"2023","unstructured":"Oh J, Oh J-M, Cho S-Y (2023) METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients. Eur Rev Med Pharmacol Sci 27:2561\u20132570. https:\/\/doi.org\/10.26355\/eurrev_202303_31793","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"11248_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01857-2","volume":"40","author":"P Hou","year":"2021","unstructured":"Hou P, Meng S, Li M et al (2021) LINC00460\/DHX9\/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification. J Exp Clin Cancer Res 40:52. https:\/\/doi.org\/10.1186\/s13046-021-01857-2","journal-title":"J Exp Clin Cancer Res"},{"key":"11248_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1653702","author":"FA Lagunas-Rangel","year":"2025","unstructured":"Lagunas-Rangel FA, Jonsson J, Jackevica L et al (2025) Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2025.1653702","journal-title":"Front Pharmacol"},{"key":"11248_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06287-w","volume":"14","author":"Y Sun","year":"2023","unstructured":"Sun Y, Gong W, Zhang S (2023) METTL3 promotes colorectal cancer progression through activating JAK1\/STAT3 signaling pathway. Cell Death Dis 14:765. https:\/\/doi.org\/10.1038\/s41419-023-06287-w","journal-title":"Cell Death Dis"},{"key":"11248_CR43","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/s41417-024-00731-5","volume":"31","author":"R Yang","year":"2024","unstructured":"Yang R, Yang C, Su D et al (2024) METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1. Cancer Gene Ther 31:562\u2013573. https:\/\/doi.org\/10.1038\/s41417-024-00731-5","journal-title":"Cancer Gene Ther"},{"key":"11248_CR44","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.7150\/jca.92633","volume":"15","author":"R Sun","year":"2024","unstructured":"Sun R, Tu X, Chan S et al (2024) CBX2 deletion suppresses growth and metastasis of colorectal cancer by Mettl3-p38\/ERK MAPK signalling pathway. J Cancer 15:2123\u20132136. https:\/\/doi.org\/10.7150\/jca.92633","journal-title":"J Cancer"},{"key":"11248_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06067-6","volume":"14","author":"M Zhou","year":"2023","unstructured":"Zhou M, He J, Li Y et al (2023) N6-methyladenosine modification of REG1\u03b1 facilitates colorectal cancer progression via \u03b2-catenin\/MYC\/LDHA axis mediated glycolytic reprogramming. Cell Death Dis 14:557. https:\/\/doi.org\/10.1038\/s41419-023-06067-6","journal-title":"Cell Death Dis"},{"key":"11248_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01244-z","volume":"19","author":"P Song","year":"2020","unstructured":"Song P, Feng L, Li J et al (2020) \u03b2-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer. Mol Cancer 19:129. https:\/\/doi.org\/10.1186\/s12943-020-01244-z","journal-title":"Mol Cancer"},{"key":"11248_CR47","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.17030","author":"L Zhang","year":"2025","unstructured":"Zhang L, Yang F, Zhang X et al (2025) Identification of the pro-tumorigenic role of the ELK4\u2013METTL3\u2013CEMIP axis in colorectal carcinoma: promotion of cancer cell stemness and malignant phenotypes. J Gastroenterol Hepatol. https:\/\/doi.org\/10.1111\/jgh.17030","journal-title":"J Gastroenterol Hepatol"},{"key":"11248_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05391-7","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Gao Q, Ma S et al (2022) FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m6A-dependent manner. Cell Death Dis 13:941. https:\/\/doi.org\/10.1038\/s41419-022-05391-7","journal-title":"Cell Death Dis"},{"key":"11248_CR49","doi-asserted-by":"publisher","DOI":"10.3892\/or.2024.8842","volume":"53","author":"J Chen","year":"2024","unstructured":"Chen J, Wu H, Zuo T et al (2024) METTL3\u2013mediated N6\u2013methyladenosine modification of MMP9 mRNA promotes colorectal cancer proliferation and migration. Oncol Rep 53:9. https:\/\/doi.org\/10.3892\/or.2024.8842","journal-title":"Oncol Rep"},{"key":"11248_CR50","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009865","author":"L Wu","year":"2024","unstructured":"Wu L, Bai R, Zhang Y et al (2024) METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2024-009865","journal-title":"J Immunother Cancer"},{"key":"11248_CR51","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1053\/j.gastro.2022.06.024","volume":"163","author":"H Chen","year":"2022","unstructured":"Chen H, Pan Y, Zhou Q et al (2022) METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1\/CXCR2 axis to promote colorectal cancer. Gastroenterology 163:891\u2013907. https:\/\/doi.org\/10.1053\/j.gastro.2022.06.024","journal-title":"Gastroenterology"},{"key":"11248_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08830185.2024.2401358","volume":"44","author":"X Yuan","year":"2025","unstructured":"Yuan X, Wang Q, Zhao J et al (2025) The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 binding. Int Rev Immunol 44:1\u201316. https:\/\/doi.org\/10.1080\/08830185.2024.2401358","journal-title":"Int Rev Immunol"},{"key":"11248_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2025.112908","volume":"211","author":"FA Lagunas-Rangel","year":"2025","unstructured":"Lagunas-Rangel FA (2025) Neutrophil-to-lymphocyte ratio in aging: trends and clinical implications. Exp Gerontol 211:112908. https:\/\/doi.org\/10.1016\/j.exger.2025.112908","journal-title":"Exp Gerontol"},{"key":"11248_CR54","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104514","author":"L Wang","year":"2020","unstructured":"Wang L, Hui H, Agrawal K et al (2020) M 6 A RNA methyltransferases METTL3\/14 regulate immune responses to anti-PD\u20101 therapy. EMBO J. https:\/\/doi.org\/10.15252\/embj.2020104514","journal-title":"EMBO J"},{"key":"11248_CR55","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70089","author":"K Wu","year":"2024","unstructured":"Wu K, Li S, Hong G et al (2024) Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy. Clin Transl Med. https:\/\/doi.org\/10.1002\/ctm2.70089","journal-title":"Clin Transl Med"},{"key":"11248_CR56","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.bioactmat.2024.10.015","volume":"44","author":"Z Tan","year":"2025","unstructured":"Tan Z, Tian L, Luo Y et al (2025) Preventing postsurgical colorectal cancer relapse: a hemostatic hydrogel loaded with METTL3 inhibitor for CAR-NK cell therapy. Bioact Mater 44:236\u2013255. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.10.015","journal-title":"Bioact Mater"},{"key":"11248_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02623-5","volume":"11","author":"B Pang","year":"2025","unstructured":"Pang B, Wu H (2025) Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies. Cell Death Discov 11:321. https:\/\/doi.org\/10.1038\/s41420-025-02623-5","journal-title":"Cell Death Discov"},{"key":"11248_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01100-9","volume":"13","author":"M Ye","year":"2023","unstructured":"Ye M, Chen J, Lu F et al (2023) Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer. Cell Biosci 13:148. https:\/\/doi.org\/10.1186\/s13578-023-01100-9","journal-title":"Cell Biosci"},{"key":"11248_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01190-w","volume":"19","author":"C Shen","year":"2020","unstructured":"Shen C, Xuan B, Yan T et al (2020) M6A-dependent glycolysis enhances colorectal cancer progression. Mol Cancer 19:72. https:\/\/doi.org\/10.1186\/s12943-020-01190-w","journal-title":"Mol Cancer"},{"key":"11248_CR60","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1053\/j.gastro.2020.11.013","volume":"160","author":"H Chen","year":"2021","unstructured":"Chen H, Gao S, Liu W et al (2021) RNA N6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m6A-GLUT1-mTORC1 axis and is a therapeutic target. Gastroenterology 160:1284-1300e16. https:\/\/doi.org\/10.1053\/j.gastro.2020.11.013","journal-title":"Gastroenterology"},{"key":"11248_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2025.1579054","volume":"15","author":"FA Lagunas-Rangel","year":"2025","unstructured":"Lagunas-Rangel FA (2025) Cholesterol effects on the tumor immune microenvironment: from fundamental concepts to mechanisms and implications. Front Oncol 15:1\u201318. https:\/\/doi.org\/10.3389\/fonc.2025.1579054","journal-title":"Front Oncol"},{"key":"11248_CR62","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1113\/EP090273","volume":"107","author":"M He","year":"2022","unstructured":"He M, Jiang D, Xun A et al (2022) Methyltransferase like 3 enhances Pinin mRNA stability through N 6 -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma. Exp Physiol 107:1283\u20131297. https:\/\/doi.org\/10.1113\/EP090273","journal-title":"Exp Physiol"},{"key":"11248_CR63","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.bcp.2018.12.014","volume":"160","author":"MB Uddin","year":"2019","unstructured":"Uddin MB, Roy KR, Hosain SB et al (2019) An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells. Biochem Pharmacol 160:134\u2013145. https:\/\/doi.org\/10.1016\/j.bcp.2018.12.014","journal-title":"Biochem Pharmacol"},{"key":"11248_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-024-00511-z","volume":"19","author":"H Ren","year":"2024","unstructured":"Ren H, Wang M, Ma X et al (2024) METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification. Biol Direct 19:68. https:\/\/doi.org\/10.1186\/s13062-024-00511-z","journal-title":"Biol Direct"},{"key":"11248_CR65","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.7150\/jca.96760","volume":"15","author":"Y Yu","year":"2024","unstructured":"Yu Y, Hai Y, Zhou H et al (2024) METTL3 inhibition suppresses cell growth and survival in colorectal cancer via ASNS downregulation. J Cancer 15:4853\u20134865. https:\/\/doi.org\/10.7150\/jca.96760","journal-title":"J Cancer"},{"key":"11248_CR66","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.7150\/thno.73746","volume":"12","author":"K Zhang","year":"2022","unstructured":"Zhang K, Zhang T, Yang Y et al (2022) N 6 -methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming. Theranostics 12:4802\u20134817. https:\/\/doi.org\/10.7150\/thno.73746","journal-title":"Theranostics"},{"key":"11248_CR67","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5396","volume":"61","author":"M Li","year":"2022","unstructured":"Li M, Xia M, Zhang Z et al (2022) METTL3 antagonizes 5\u2013FU chemotherapy and confers drug resistance in colorectal carcinoma. Int J Oncol 61:106. https:\/\/doi.org\/10.3892\/ijo.2022.5396","journal-title":"Int J Oncol"},{"key":"11248_CR68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/hon.3076","volume":"41","author":"FA Lagunas-Rangel","year":"2023","unstructured":"Lagunas-Rangel FA (2023) DNA damage accumulation and repair defects in FLT3\u2010ITD acute myeloid leukemia: implications for clonal evolution and disease progression. Hematol Oncol 41:26\u201338. https:\/\/doi.org\/10.1002\/hon.3076","journal-title":"Hematol Oncol"},{"issue":"1","key":"11248_CR69","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-025-10043-5","volume":"41","author":"Q Su","year":"2025","unstructured":"Su Q, Wang K, Liao R et al (2025) Dissecting the METTL3\/STC2 axis in colorectal cancer: implications for drug resistance and metastasis. Cell Biol Toxicol 41(1):100. https:\/\/doi.org\/10.1007\/s10565-025-10043-5","journal-title":"Cell Biol Toxicol"},{"key":"11248_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111676","volume":"130","author":"C Wang","year":"2025","unstructured":"Wang C, Liang W, Zhong J et al (2025) M6a-mediated regulation of CPSF6 by METTL3 promotes oxaliplatin resistance in colorectal cancer through enhanced glycolysis. Cell Signal 130:111676. https:\/\/doi.org\/10.1016\/j.cellsig.2025.111676","journal-title":"Cell Signal"},{"key":"11248_CR71","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01934-6","volume":"40","author":"X Liu","year":"2021","unstructured":"Liu X, Su K, Sun X et al (2021) Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt\/\u03b2-catenin pathway. J Exp Clin Cancer Res 40:132. https:\/\/doi.org\/10.1186\/s13046-021-01934-6","journal-title":"J Exp Clin Cancer Res"},{"key":"11248_CR72","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-020-01373-x","volume":"37","author":"FA Lagunas-Rangel","year":"2020","unstructured":"Lagunas-Rangel FA (2020) Circular RNAs and their participation in stemness of cancer. Med Oncol 37:42. https:\/\/doi.org\/10.1007\/s12032-020-01373-x","journal-title":"Med Oncol"},{"key":"11248_CR73","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4251\/wjgo.v15.i1.76","volume":"15","author":"Y Lu","year":"2023","unstructured":"Lu Y, Wang X-M, Li Z-S et al (2023) Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p\/METTL3 regulatory axis. World J Gastrointest Oncol 15:76\u201389. https:\/\/doi.org\/10.4251\/wjgo.v15.i1.76","journal-title":"World J Gastrointest Oncol"},{"key":"11248_CR74","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13306","volume":"23","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zhang B, Zhu Y et al (2022) hsa_circ_0000523\/miR\u2013let\u20137b\/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line. Oncol Lett 23:186. https:\/\/doi.org\/10.3892\/ol.2022.13306","journal-title":"Oncol Lett"},{"key":"11248_CR75","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01471-y","volume":"21","author":"R Zheng","year":"2022","unstructured":"Zheng R, Zhang K, Tan S et al (2022) Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3\u2013eIF3h interaction. Mol Cancer 21:49. https:\/\/doi.org\/10.1186\/s12943-021-01471-y","journal-title":"Mol Cancer"},{"key":"11248_CR76","doi-asserted-by":"publisher","first-page":"306","DOI":"10.7150\/ijbs.105324","volume":"21","author":"F Wang","year":"2025","unstructured":"Wang F, Wang Q, Wu Y et al (2025) CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity. Int J Biol Sci 21:306\u2013327. https:\/\/doi.org\/10.7150\/ijbs.105324","journal-title":"Int J Biol Sci"},{"key":"11248_CR77","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12474-5","volume":"24","author":"C Hou","year":"2024","unstructured":"Hou C, Liu J, Liu J et al (2024) METTL3-induced circ_0008345 contributes to the progression of colorectal cancer via the microRNA-182-5p\/CYP1A2 pathway. BMC Cancer 24:728. https:\/\/doi.org\/10.1186\/s12885-024-12474-5","journal-title":"BMC Cancer"},{"key":"11248_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154950","volume":"253","author":"X Zhong","year":"2024","unstructured":"Zhong X, Peng Y, Zhang X et al (2024) M6A-modified circ_0124554 promotes colorectal cancer progression and radioresistance through the miR-1184\/LASP1 pathway. Pathology 253:154950. https:\/\/doi.org\/10.1016\/j.prp.2023.154950","journal-title":"Pathology"},{"key":"11248_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/srep25631","volume":"6","author":"Z Shao","year":"2016","unstructured":"Shao Z, Cai Y, Xu L et al (2016) Loss of the 14-3-3\u03c3 is essential for LASP1-mediated colorectal cancer progression via activating PI3K\/AKT signaling pathway. Sci Rep 6:25631. https:\/\/doi.org\/10.1038\/srep25631","journal-title":"Sci Rep"},{"key":"11248_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15123148","volume":"15","author":"M Chen","year":"2023","unstructured":"Chen M, Tian B, Hu G, Guo Y (2023) METTL3-modulated circUHRF2 promotes colorectal cancer stemness and metastasis through increasing DDX27 mRNA stability by recruiting IGF2BP1. Cancers (Basel) 15:3148. https:\/\/doi.org\/10.3390\/cancers15123148","journal-title":"Cancers (Basel)"},{"key":"11248_CR81","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.7150\/thno.51342","volume":"11","author":"C Chen","year":"2021","unstructured":"Chen C, Yuan W, Zhou Q et al (2021) N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization. Theranostics 11:4298\u20134315. https:\/\/doi.org\/10.7150\/thno.51342","journal-title":"Theranostics"},{"key":"11248_CR82","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s13577-022-00835-w","volume":"36","author":"J Tang","year":"2023","unstructured":"Tang J, Huang M, Peng H et al (2023) METTL3-mediated Hsa_circ_0000390 downregulation enhances the proliferation, migration, and invasion of colorectal cancer cells by increasing Notch1 expression. Hum Cell 36:703\u2013711. https:\/\/doi.org\/10.1007\/s13577-022-00835-w","journal-title":"Hum Cell"},{"key":"11248_CR83","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/jgh.15775","volume":"37","author":"Q Liu","year":"2022","unstructured":"Liu Q, Huang Q, Liu H et al (2022) Sumoylation of methyltransferase-like 3 facilitates colorectal cancer progression by promoting circ_0000677 in an m 6 A\u2010dependent manner. J Gastroenterol Hepatol 37:700\u2013713. https:\/\/doi.org\/10.1111\/jgh.15775","journal-title":"J Gastroenterol Hepatol"},{"key":"11248_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100886","volume":"65","author":"Z Liu","year":"2022","unstructured":"Liu Z, Zheng N, Li J et al (2022) N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells. Drug Resist Updat 65:100886. https:\/\/doi.org\/10.1016\/j.drup.2022.100886","journal-title":"Drug Resist Updat"},{"key":"11248_CR85","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-01962-8","volume":"23","author":"T Jiang","year":"2024","unstructured":"Jiang T, Qi J, Xue Z et al (2024) The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN. Mol Cancer 23:55. https:\/\/doi.org\/10.1186\/s12943-024-01962-8","journal-title":"Mol Cancer"},{"key":"11248_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217004","volume":"596","author":"Y Bian","year":"2024","unstructured":"Bian Y, Xu S, Gao Z et al (2024) M6A modification of LncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21\/IGF2BP2\/ FOXM1 positive feedback loop. Cancer Lett 596:217004. https:\/\/doi.org\/10.1016\/j.canlet.2024.217004","journal-title":"Cancer Lett"},{"key":"11248_CR87","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.669731","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Wang Y, Liu Y et al (2021) N6-methyladenosine modification of PTTG3P contributes to colorectal cancer proliferation via YAP1. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2021.669731","journal-title":"Front Oncol"},{"key":"11248_CR88","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02288-x","volume":"21","author":"R-Z He","year":"2021","unstructured":"He R-Z, Jiang J, Hu X et al (2021) Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression. Cancer Cell Int 21:616. https:\/\/doi.org\/10.1186\/s12935-021-02288-x","journal-title":"Cancer Cell Int"},{"key":"11248_CR89","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02180-8","volume":"21","author":"M Yue","year":"2021","unstructured":"Yue M, Liu T, Yan G et al (2021) LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer. Cancer Cell Int 21:504. https:\/\/doi.org\/10.1186\/s12935-021-02180-8","journal-title":"Cancer Cell Int"},{"key":"11248_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193008","volume":"11","author":"Y Bian","year":"2022","unstructured":"Bian Y, Wang Y, Xu S et al (2022) M6A modification of long non-coding RNA HNF1A-AS1 facilitates cell cycle progression in colorectal cancer via IGF2BP2-mediated CCND1 mRNA stabilization. Cells 11:3008. https:\/\/doi.org\/10.3390\/cells11193008","journal-title":"Cells"},{"key":"11248_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02365-4","volume":"11","author":"H Zhang","year":"2025","unstructured":"Zhang H, Han Y, Wu C et al (2025) M6A-modified LINC02418 induces transcriptional and post-transcriptional modification of CTNNB1 via interacting with YBX1 and IGF2BP1 in colorectal cancer. Cell Death Discov 11:101. https:\/\/doi.org\/10.1038\/s41420-025-02365-4","journal-title":"Cell Death Discov"},{"key":"11248_CR92","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2023.5529","volume":"63","author":"W Liu","year":"2023","unstructured":"Liu W, Zhang Z, Luo X et al (2023) M 6 A\u2013mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A\/PI3K\/AKT pathway via competitive binding with miR\u2013552\u20135p. Int J Oncol 63:81. https:\/\/doi.org\/10.3892\/ijo.2023.5529","journal-title":"Int J Oncol"},{"key":"11248_CR93","doi-asserted-by":"publisher","first-page":"654","DOI":"10.5009\/gnl230385","volume":"18","author":"C-H Song","year":"2024","unstructured":"Song C-H, Kim N, Nam RH et al (2024) The possible preventative role of lactate- and butyrate-producing bacteria in colorectal carcinogenesis. Gut Liver 18:654\u2013666. https:\/\/doi.org\/10.5009\/gnl230385","journal-title":"Gut Liver"},{"key":"11248_CR94","doi-asserted-by":"publisher","unstructured":"Lagunas-Rangel FA (2025) Bidirectional relationship between Statins and the gut microbiota: implications for cardiovascular health, diabetes, and cancer. Xenobiotica 1\u201312. https:\/\/doi.org\/10.1080\/00498254.2025.2535445","DOI":"10.1080\/00498254.2025.2535445"},{"key":"11248_CR95","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1111\/cas.15839","volume":"114","author":"K Zhang","year":"2023","unstructured":"Zhang K, Dong Y, Li M et al (2023) Clostridium butyricum inhibits epithelial\u2013mesenchymal transition of intestinal carcinogenesis through downregulating METTL3. Cancer Sci 114:3114\u20133127. https:\/\/doi.org\/10.1111\/cas.15839","journal-title":"Cancer Sci"},{"key":"11248_CR96","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","volume":"17","author":"CA Brennan","year":"2019","unstructured":"Brennan CA, Garrett WS (2019) Fusobacterium nucleatum \u2014 symbiont, opportunist and oncobacterium. Nat Rev Microbiol 17:156\u2013166. https:\/\/doi.org\/10.1038\/s41579-018-0129-6","journal-title":"Nat Rev Microbiol"},{"key":"11248_CR97","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1111\/cas.15536","volume":"113","author":"Q Xu","year":"2022","unstructured":"Xu Q, Lu X, Li J et al (2022) Fusobacterium nucleatum induces excess methyltransferase-like 3\u2010mediated microRNA\u20104717\u20103p maturation to promote colorectal cancer cell proliferation. Cancer Sci 113:3787\u20133800. https:\/\/doi.org\/10.1111\/cas.15536","journal-title":"Cancer Sci"},{"key":"11248_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28913-5","volume":"13","author":"S Chen","year":"2022","unstructured":"Chen S, Zhang L, Li M et al (2022) Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis. Nat Commun 13:1248. https:\/\/doi.org\/10.1038\/s41467-022-28913-5","journal-title":"Nat Commun"},{"key":"11248_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105041","volume":"102","author":"G Li","year":"2024","unstructured":"Li G, Liu H, Yu Y et al (2024) Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3. eBioMedicine 102:105041. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105041","journal-title":"eBioMedicine"},{"key":"11248_CR100","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3892\/or.2020.7665","volume":"44","author":"J Xu","year":"2020","unstructured":"Xu J, Chen Q, Tian K et al (2020) M6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation. Oncol Rep 44:973\u2013986. https:\/\/doi.org\/10.3892\/or.2020.7665","journal-title":"Oncol Rep"},{"key":"11248_CR101","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12936","volume":"22","author":"B Alkhizzi","year":"2021","unstructured":"Alkhizzi B, Khan M, Al\u2013Ghafari A, Choudhry H (2021) Upregulation of circular and linear METTL3 and USP3 in colorectal cancer. Oncol Lett 22:675. https:\/\/doi.org\/10.3892\/ol.2021.12936","journal-title":"Oncol Lett"},{"key":"11248_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117560","volume":"290","author":"G Li","year":"2025","unstructured":"Li G, Chen W, Liu D, Tang S (2025) Recent advances in medicinal chemistry strategies for the development of METTL3 inhibitors. Eur J Med Chem 290:117560. https:\/\/doi.org\/10.1016\/j.ejmech.2025.117560","journal-title":"Eur J Med Chem"},{"key":"11248_CR103","unstructured":"National Library of Medicine ClinicalTrials.gov. In (2024) https:\/\/clinicaltrials.gov. Accessed 13 Apr 2024"},{"key":"11248_CR104","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.1016\/S0959-8049(22)01128-5","volume":"174","author":"Y Ofir-Rosenfeld","year":"2022","unstructured":"Ofir-Rosenfeld Y, Vasiliauskait\u0117 L, Saunders C et al (2022) STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade. Eur J Cancer 174:S123. https:\/\/doi.org\/10.1016\/S0959-8049(22)01128-5","journal-title":"Eur J Cancer"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11248-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11248-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11248-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:20:23Z","timestamp":1763554823000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11248-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":104,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11248"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11248-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"18 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declares no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"98"}}