{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:46:53Z","timestamp":1793821613319,"version":"4.6.1"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11255-y","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:38:37Z","timestamp":1763635117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing diabetic foot ulcer therapy: structure\u2013activity relationship approaches for combating reactive oxygen species"],"prefix":"10.1007","volume":"53","author":[{"given":"Manish","family":"Kaushik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-2960","authenticated-orcid":false,"given":"Aditi","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-3624","authenticated-orcid":false,"given":"Bhupendra","family":"Koul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amardeep","family":"Ankalgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Ashawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"issue":"12","key":"11255_CR1","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.4239\/wjd.v13.i12.1049","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X, Yuan C-X, Xu B, Yu Z (2022) Diabetic foot ulcers: classification, risk factors and management. World J Diabetes 13(12):1049\u20131065","journal-title":"World J Diabetes"},{"key":"11255_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/1753-0407.12644","volume":"10","author":"AM Carracher","year":"2018","unstructured":"Carracher AM, Marathe PH, Close KL (2018) International Diabetes Federation 2017. J Diabetes 10:353\u2013356","journal-title":"J Diabetes"},{"key":"11255_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","volume":"49","author":"P Zhang","year":"2017","unstructured":"Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y (2017) Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med 49:106\u2013116","journal-title":"Ann Med"},{"key":"11255_CR4","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA et al (2017) Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care 40:136\u2013154","journal-title":"Diabetes Care"},{"key":"11255_CR5","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.2337\/dc14-1982","volume":"38","author":"SJ Brown","year":"2015","unstructured":"Brown SJ, Handsaker JC, Bowling FL, Boulton AJ, Reeves ND (2015) Diabetic peripheral neuropathy compromises balance during daily activities. Diabetes Care 38:1116\u20131122","journal-title":"Diabetes Care"},{"key":"11255_CR6","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1111\/dme.13054","volume":"33","author":"JW Walsh","year":"2016","unstructured":"Walsh JW, Hoffstad OJ, Sullivan MO, Margolis DJ (2016) Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom. Diabet Med 33:1493\u20131498","journal-title":"Diabet Med"},{"key":"11255_CR7","doi-asserted-by":"publisher","first-page":"e3269","DOI":"10.1002\/dmrr.3269","volume":"36","author":"SA Bus","year":"2020","unstructured":"Bus SA, Lavery LA, Monteiro-Soares M, Rasmussen A, Raspovic A, Sacco ICN et al (2020) International working group on the diabetic Foot. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev 36:e3269","journal-title":"Diabetes Metab Res Rev"},{"issue":"3","key":"11255_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3651","volume":"40","author":"SA Bus","year":"2024","unstructured":"Bus SA, Sacco CNI, Monteiro-Soares M, Raspovic A, Paton J, Rasmussen A, Lavery LA, Netten JJV (2024) Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev 40(3):e3651","journal-title":"Diabetes Metab Res Rev"},{"key":"11255_CR9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2337\/db09-0801","volume":"59","author":"D Yao","year":"2010","unstructured":"Yao D, Brownlee M (2010) Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 59:249\u2013255","journal-title":"Diabetes"},{"issue":"10","key":"11255_CR10","first-page":"2795","volume":"12","author":"AM Vincent","year":"2004","unstructured":"Vincent AM, Feldman EL (2004) Control of cell survival by IGF signaling pathways. Bioorg Med Chem 12(10):2795\u20132807","journal-title":"Bioorg Med Chem"},{"key":"11255_CR11","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/414813a","volume":"414","author":"M Brownlee","year":"2001","unstructured":"Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813\u2013820. https:\/\/doi.org\/10.1038\/414813a","journal-title":"Nature"},{"issue":"1","key":"11255_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"JM Forbes","year":"2013","unstructured":"Forbes JM, Cooper ME (2013) Mechanisms of diabetic complications. Physiol Rev 93(1):137\u2013188. https:\/\/doi.org\/10.1152\/physrev.00045.2011","journal-title":"Physiol Rev"},{"issue":"9","key":"11255_CR13","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107(9):1058\u20131070","journal-title":"Circ Res"},{"issue":"17","key":"11255_CR14","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.1016\/j.bmc.2005.05.010","volume":"13","author":"R Ramasamy","year":"2005","unstructured":"Ramasamy R, Yan SF, Schmidt AM (2005) The RAGE axis and endothelial dysfunction in diabetes. Bioorg Med Chem 13(17):4777\u20134783. https:\/\/doi.org\/10.1016\/j.bmc.2005.05.010","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"11255_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2337\/db07-0916","volume":"57","author":"CCE Lan","year":"2008","unstructured":"Lan CCE et al (2008) High glucose environment increases matrix metalloproteinase-9 expression in keratinocytes: implications for impaired diabetic wound healing. Diabetes 57(2):387\u2013395. https:\/\/doi.org\/10.2337\/db07-0916","journal-title":"Diabetes"},{"issue":"1","key":"11255_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1524-475X.2008.00436.x","volume":"17","author":"CK Sen","year":"2009","unstructured":"Sen CK (2009) Wound healing essentials: let there be oxygen. Wound Repair Regen 17(1):1\u201318. https:\/\/doi.org\/10.1111\/j.1524-475X.2008.00436.x","journal-title":"Wound Repair Regen"},{"key":"11255_CR17","doi-asserted-by":"publisher","first-page":"116589","DOI":"10.1016\/j.bmc.2022.116589","volume":"60","author":"Y Pan","year":"2022","unstructured":"Pan Y et al (2022) ROS-responsive drug delivery systems for diabetic wound healing. Bioorg Med Chem 60:116589. https:\/\/doi.org\/10.1016\/j.bmc.2022.116589","journal-title":"Bioorg Med Chem"},{"issue":"5","key":"11255_CR18","doi-asserted-by":"publisher","first-page":"115312","DOI":"10.1016\/j.bmc.2020.115312","volume":"28","author":"Y Liu","year":"2020","unstructured":"Liu Y et al (2020) Mitochondrial dysfunction and oxidative stress contribute to impaired wound healing in diabetes: targeting ROS for therapeutic intervention. Bioorg Med Chem 28(5):115312. https:\/\/doi.org\/10.1016\/j.bmc.2020.115312","journal-title":"Bioorg Med Chem"},{"key":"11255_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2019.08.015","volume":"143","author":"L Zhou","year":"2019","unstructured":"Zhou L et al (2019) NADPH oxidase-derived ROS in diabetic complications: mechanisms and therapeutic potential. Free Radic Biol Med 143:153\u2013168. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.08.015","journal-title":"Free Radic Biol Med"},{"key":"11255_CR20","doi-asserted-by":"publisher","first-page":"116147","DOI":"10.1016\/j.bmc.2021.116147","volume":"39","author":"Y Wang","year":"2021","unstructured":"Wang Y et al (2021) Targeted antioxidant delivery systems for chronic wound healing in diabetes: A review of recent advances. Bioorg Med Chem 39:116147. https:\/\/doi.org\/10.1016\/j.bmc.2021.116147","journal-title":"Bioorg Med Chem"},{"issue":"17","key":"11255_CR21","doi-asserted-by":"publisher","first-page":"5437","DOI":"10.1016\/j.bmc.2005.04.010","volume":"13","author":"M Brownlee","year":"2005","unstructured":"Brownlee M (2005) Biochemistry and molecular cell biology of diabetic complications. Bioorg Med Chem 13(17):5437\u20135445. https:\/\/doi.org\/10.1016\/j.bmc.2005.04.010","journal-title":"Bioorg Med Chem"},{"key":"11255_CR22","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/35008121","volume":"404","author":"T Nishikawa","year":"2000","unstructured":"Nishikawa T, Edelstein D, Du X, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787\u2013790. https:\/\/doi.org\/10.1038\/35008121","journal-title":"Nature"},{"issue":"9","key":"11255_CR23","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107(9):1058\u20131070. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.223545","journal-title":"Circ Res"},{"issue":"4","key":"11255_CR24","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1210\/er.2003-0019","volume":"25","author":"AM Vincent","year":"2004","unstructured":"Vincent AM, Russell JW, Low P, Feldman EL (2004) Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 25(4):612\u2013628. https:\/\/doi.org\/10.1210\/er.2003-0019","journal-title":"Endocr Rev"},{"key":"11255_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","volume":"1243","author":"R Ramasamy","year":"2011","unstructured":"Ramasamy R, Yan SF, Schmidt AM (2011) Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci 1243:88\u2013102. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06320.x","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"11255_CR26","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.1161\/01.RES.88.2.e14","volume":"88","author":"U Hink","year":"2001","unstructured":"Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling KK, Harrison DG, F\u00f6rstermann U, M\u00fcnzel T (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88(2):E14\u2013E22. https:\/\/doi.org\/10.1161\/01.RES.88.2.e14","journal-title":"Circ Res"},{"issue":"5","key":"11255_CR27","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1161\/01.ATV.0000122852.22604.78","volume":"24","author":"A Ceriello","year":"2004","unstructured":"Ceriello A, Motz E (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24(5):816\u2013823. https:\/\/doi.org\/10.1161\/01.ATV.0000122852.22604.78","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"11255_CR28","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrneurol.2011.137","volume":"7","author":"AM Vincent","year":"2011","unstructured":"Vincent AM, Callaghan BC, Smith AL, Feldman EL (2011) Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol 7(10):573\u2013583. https:\/\/doi.org\/10.1038\/nrneurol.2011.137","journal-title":"Nat Rev Neurol"},{"issue":"Suppl 2","key":"11255_CR29","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.2337\/diab.46.2.S31","volume":"46","author":"NE Cameron","year":"1997","unstructured":"Cameron NE, Cotter MA (1997) Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 46(Suppl 2):S31\u2013S38. https:\/\/doi.org\/10.2337\/diab.46.2.S31","journal-title":"Diabetes"},{"issue":"6","key":"11255_CR30","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.neuron.2017.02.005","volume":"93","author":"EL Feldman","year":"2017","unstructured":"Feldman EL, Nave KA, Jensen TS, Bennett DL (2017) New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain. Neuron 93(6):1296\u20131313. https:\/\/doi.org\/10.1016\/j.neuron.2017.02.005","journal-title":"Neuron"},{"issue":"4","key":"11255_CR31","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.nurt.2009.07.006","volume":"6","author":"IG Obrosova","year":"2009","unstructured":"Obrosova IG (2009) Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics 6(4):638\u2013647. https:\/\/doi.org\/10.1016\/j.nurt.2009.07.006","journal-title":"Neurotherapeutics"},{"issue":"10","key":"11255_CR32","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.2337\/dc10-1303","volume":"33","author":"S Tesfaye","year":"2010","unstructured":"Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P (2010) Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 33(10):2285\u20132293. https:\/\/doi.org\/10.2337\/dc10-1303","journal-title":"Diabetes Care"},{"key":"11255_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01965-7","volume":"22","author":"Y An","year":"2023","unstructured":"An Y, Xu B, Wan S, Ma X, Long Y, Xu Y, Jiang Z (2023) The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 22:65","journal-title":"Cardiovasc Diabetol"},{"key":"11255_CR34","doi-asserted-by":"crossref","unstructured":"Nikolaeva M, Johnstone M (2023) Nitric oxide, its role in diabetes mellitus and methods to improve endothelial function. In: Sethi R (ed) Contemporary cardiology: advances in vascular medicine. Springer, Cham, pp 131\u2013150","DOI":"10.1007\/978-3-031-13177-6_7"},{"issue":"4","key":"11255_CR35","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/path.1439","volume":"200","author":"EC Tsilibary","year":"2003","unstructured":"Tsilibary EC (2003) Microvascular basement membranes in diabetes mellitus. J Pathol 200(4):537\u2013546","journal-title":"J Pathol"},{"issue":"2","key":"11255_CR36","first-page":"124","volume":"3","author":"AT Babakr","year":"2025","unstructured":"Babakr AT (2025) Oxidized low-density lipoproteins and their contribution to atherosclerosis. Explor Cardiol 3(2):124\u2013136","journal-title":"Explor Cardiol"},{"issue":"4","key":"11255_CR37","first-page":"543","volume":"31","author":"LA Lavery","year":"2023","unstructured":"Lavery LA, Suludere MA, Attinger CE et al (2023) WHS guidelines update: diabetic foot ulcer treatment guidelines. Wound Repair Regen 31(4):543\u2013558","journal-title":"Wound Repair Regen"},{"key":"11255_CR38","doi-asserted-by":"publisher","first-page":"162547","DOI":"10.3389\/fcell.2025.1625474","volume":"13","author":"Y Pan","year":"2025","unstructured":"Pan Y, Chen L, Chen Y et al (2025) Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies. Front Cell Dev Biol 13:162547","journal-title":"Front Cell Dev Biol"},{"key":"11255_CR39","volume":"8","author":"Y Li","year":"2023","unstructured":"Li Y, Liu Y, Liu S et al (2023) Diabetic vascular diseases: molecular mechanisms and therapeutic strategies. Signal Transduct Target Ther 8:400","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"11255_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13051076","volume":"13","author":"J Dawi","year":"2025","unstructured":"Dawi J, Tumanyan K, Tomas K, Misakyan Y, Gargaloyan A, Gonzalez E, Hammi M, Tomas S, Venketaraman V (2025) Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies. Biomedicines 13(5):1076","journal-title":"Biomedicines"},{"key":"11255_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0135-z","volume":"9","author":"CMO Volpe","year":"2018","unstructured":"Volpe CMO, Villar-Delfino PH, Ferreira PMA, Nogueira-Machado JA (2018) Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis 9:119","journal-title":"Cell Death Dis"},{"key":"11255_CR42","doi-asserted-by":"publisher","first-page":"678771","DOI":"10.3389\/fimmu.2021.678771","volume":"12","author":"R Dowey","year":"2021","unstructured":"Dowey R, Iqbal A, Heller SR, Sabroe I, Prince LR (2021) A bittersweet response to infection in diabetes: targeting neutrophils to modify inflammation and improve host immunity. Front Immunol 12:678771","journal-title":"Front Immunol"},{"key":"11255_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac051","volume":"10","author":"X Wu","year":"2022","unstructured":"Wu X, He W, Mu X, Liu Y, Deng J, Liu Y, Nie X (2022) Macrophage polarization in diabetic wound healing. Burns Trauma 10:tkac051","journal-title":"Burns Trauma"},{"issue":"6","key":"11255_CR44","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.2337\/db14-1322","volume":"64","author":"A Yu","year":"2015","unstructured":"Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, Malek TR (2015) Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64(6):2172\u20132183","journal-title":"Diabetes"},{"key":"11255_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf020","volume":"13","author":"R Wang","year":"2025","unstructured":"Wang R, Li B, Dong M, Zhu H, Jin P, Zou Y (2025) Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies. Burns Trauma 13:tkaf020","journal-title":"Burns Trauma"},{"issue":"1","key":"11255_CR46","volume":"3","author":"E Colomb","year":"2020","unstructured":"Colomb E, Das A, Santra S, Roy S (2020) Wound microbiome, biofilm infection and interactions with host immune cells in diabetic foot ulcers. IMPRS Proc 3(1):24575","journal-title":"IMPRS Proc"},{"key":"11255_CR47","doi-asserted-by":"publisher","first-page":"17448","DOI":"10.1039\/D4RA02349H","volume":"14","author":"G Bennici","year":"2024","unstructured":"Bennici G, Almahasheer H, Alghrably M, Valensin D, Kola A, Kokotidou C, Lachowicz J, Jaremko M (2024) Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through pharmacological interventions. RSC Adv 14:17448\u201317460","journal-title":"RSC Adv"},{"issue":"4","key":"11255_CR48","doi-asserted-by":"publisher","first-page":"5355","DOI":"10.1007\/s11033-023-08392-7","volume":"50","author":"F Cai","year":"2023","unstructured":"Cai F, Chen W, Zhao R, Liu Y (2023) Mechanisms of Nrf2 and NF-\u03baB pathways in diabetic wound and potential treatment strategies. Mol Biol Rep 50(4):5355\u20135367","journal-title":"Mol Biol Rep"},{"key":"11255_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117058","volume":"177","author":"JP Yadav","year":"2024","unstructured":"Yadav JP, Verma A, Pathak P, Dwivedi AR, Singh AK, Kumar P et al (2024) Phytoconstituents as modulators of NF-\u03baB signalling: investigating therapeutic potential for diabetic wound healing. Biomed Pharmacother 177:117058","journal-title":"Biomed Pharmacother"},{"key":"11255_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01431-w","volume":"28","author":"J Liu","year":"2023","unstructured":"Liu J, Pan S, Wang X, Liu Z, Zhang Y (2023) Role of advanced glycation end products in diabetic vascular injury: molecular mechanisms and therapeutic perspectives. Eur J Med Res 28:553","journal-title":"Eur J Med Res"},{"issue":"2","key":"11255_CR51","first-page":"45","volume":"13","author":"CE DeClue","year":"2023","unstructured":"DeClue CE, Shornick LP (2023) The cytokine milieu of diabetic wounds. Diabetes Manag 13(2):45\u201358","journal-title":"Diabetes Manag"},{"key":"11255_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216321","volume":"14","author":"S Nirenjen","year":"2023","unstructured":"Nirenjen S, Narayanan J, Tamilanban T, Subramaniyan V, Chitra V, Fuloria NK et al (2023) Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes. Front Immunol 14:1216321","journal-title":"Front Immunol"},{"key":"11255_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1050630","volume":"13","author":"K Fu","year":"2022","unstructured":"Fu K, Zheng X, Chen Y, Wu L, Yang Z, Chen X, Song W (2022) Role of matrix metalloproteinases in diabetic foot ulcers: potential therapeutic targets. Front Pharmacol 13:1050630","journal-title":"Front Pharmacol"},{"key":"11255_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8852759","volume":"2021","author":"L Deng","year":"2021","unstructured":"Deng L, Du C, Song P, Chen T, Rui S, Armstrong DG, Deng W (2021) The role of oxidative stress and antioxidants in diabetic wound healing. Oxid Med Cell Longev 2021:8852759","journal-title":"Oxid Med Cell Longev"},{"key":"11255_CR55","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae052","volume":"13","author":"K Huang","year":"2025","unstructured":"Huang K, Mi B, Xiong Y, Fu Z, Zhou W, Liu W, Liu G, Dai G (2025) Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns Trauma 13:tkae052","journal-title":"Burns Trauma"},{"issue":"7","key":"11255_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419","volume":"18","author":"UA Okonkwo","year":"2017","unstructured":"Okonkwo UA, DiPietro LA (2017) Diabetes and wound angiogenesis. Int J Mol Sci 18(7):1419","journal-title":"Int J Mol Sci"},{"issue":"4","key":"11255_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042172","volume":"25","author":"FA Voza","year":"2024","unstructured":"Voza FA, Huerta CT, Le N, Shao H, Ribieras A, Ortiz Y, Atkinson C, Machuca T, Liu ZJ, Velazquez OC (2024) Fibroblasts in diabetic foot ulcers. Int J Mol Sci 25(4):2172","journal-title":"Int J Mol Sci"},{"key":"11255_CR58","doi-asserted-by":"crossref","unstructured":"Hegazi S, Aly R, Mesilhy R, Aljohary H (2024) Diabetic foot ulcer wound healing and tissue regeneration: signaling pathways and mechanisms. In: Chowdhury MEH, Zughaier SM, Hasan A, Alfkey R (eds) Diabetic foot Ulcers - Pathogenesis, innovative treatments and AI applications. IntechOpen, London, pp 1\u201328","DOI":"10.5772\/intechopen.1004267"},{"key":"11255_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.707479","volume":"9","author":"W Zhang","year":"2021","unstructured":"Zhang W, Chen L, Xiong Y, Panayi AC, Abududilibaier A, Hu Y, Yu C, Zhou W, Sun Y, Liu M, Xue H, Hu L, Yan C, Xie X, Lin Z, Cao F, Mi B, Liu G (2021) Antioxidant therapy and antioxidant-related bionanomaterials in diabetic wound healing. Front Bioeng Biotechnol 9:707479","journal-title":"Front Bioeng Biotechnol"},{"key":"11255_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01965-7","volume":"22","author":"Y An","year":"2023","unstructured":"An Y, Xu B, Wan S, Ma X, Long Y, Xu Y, Jiang Z (2023) The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 22:237","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"11255_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104884","volume":"26","author":"H Elajaili","year":"2025","unstructured":"Elajaili H, Lyttle BD, Lewis CV, Bardill JR, Dee N, Seal S, Nozik ES, Liechty KW, Zgheib C (2025) Increased ROS and persistent pro-inflammatory responses in a diabetic wound healing model (db\/db): implications for delayed wound healing. Int J Mol Sci 26(10):4884","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11255_CR62","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvp031","volume":"82","author":"L Gao","year":"2009","unstructured":"Gao L, Mann GE (2009) Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling. Cardiovasc Res 82(1):9\u201320","journal-title":"Cardiovasc Res"},{"issue":"2","key":"11255_CR63","first-page":"149","volume":"20","author":"M Munteanu","year":"2013","unstructured":"Munteanu M, Sturza A, Schiller A, Timar R (2013) Endothelial dysfunction in diabetes \u2013 classic sources of vascular oxidative stress (NADPH oxidases, eNOS uncoupling and xanthine oxidase). Rom J Diabetes Nutr Metab Dis 20(2):149\u2013155","journal-title":"Rom J Diabetes Nutr Metab Dis"},{"issue":"4","key":"11255_CR64","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1161\/CIRCULATIONAHA.110.014506","volume":"124","author":"SM Shenouda","year":"2011","unstructured":"Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE et al (2011) Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 124(4):444\u2013453","journal-title":"Circulation"},{"issue":"3","key":"11255_CR65","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00395-022-00976-x","volume":"118","author":"RB Teixeira","year":"2023","unstructured":"Teixeira RB, Pfeiffer M, Zhang P, Shafique E, Rayta B, Karbasiafshar C et al (2023) Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction. Basic Res Cardiol 118(3):3","journal-title":"Basic Res Cardiol"},{"key":"11255_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1112363","volume":"14","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Huang Q, Zhao D, Lian F, Li X, Qi W (2023) The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications. Front Endocrinol 14:1112363","journal-title":"Front Endocrinol"},{"issue":"6","key":"11255_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060890","volume":"10","author":"A Vermot","year":"2021","unstructured":"Vermot A, Petit-H\u00e4rtlein I, Smith SME, Fieschi F (2021) NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology. Antioxidants 10(6):890","journal-title":"Antioxidants"},{"key":"11255_CR68","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/s41423-022-00858-1","volume":"19","author":"R Begum","year":"2022","unstructured":"Begum R, Thota S, Abdulkadir A, Kaur G, Bagam P, Batra S (2022) NADPH oxidase family proteins: signaling dynamics to disease management. Cell Mol Immunol 19:660\u2013686","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"11255_CR69","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s00216-015-8481-0","volume":"407","author":"J Liu","year":"2015","unstructured":"Liu J, Wang C, Liu F, Lu Y, Cheng J (2015) Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy. Anal Bioanal Chem 407(9):2569\u20132579","journal-title":"Anal Bioanal Chem"},{"issue":"4","key":"11255_CR70","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s10157-018-1530-1","volume":"22","author":"T Wada","year":"2018","unstructured":"Wada T, Hosoya T, Honda D, Sakamoto R, Narita K, Sasaki T et al (2018) Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). Clin Exp Nephrol 22(4):860\u2013870","journal-title":"Clin Exp Nephrol"},{"issue":"3","key":"11255_CR71","doi-asserted-by":"publisher","first-page":"666","DOI":"10.2337\/db06-0699","volume":"56","author":"T Thum","year":"2007","unstructured":"Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD et al (2007) Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes 56(3):666\u2013674","journal-title":"Diabetes"},{"issue":"3","key":"11255_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13030312","volume":"13","author":"Y Hong","year":"2024","unstructured":"Hong Y, Boiti A, Vallone D, Foulkes NS (2024) Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution. Antioxidants 13(3):312","journal-title":"Antioxidants"},{"key":"11255_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.714370","volume":"9","author":"SA Sinenko","year":"2021","unstructured":"Sinenko SA, Starkova TY, Kuzmin AA, Tomilin AN (2021) Physiological signaling functions of reactive oxygen species in stem cells: from flies to man. Front Cell Dev Biol 9:714370","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"11255_CR74","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1039\/C9MD00169G","volume":"10","author":"J Peir\u00f3 Cadah\u00eda","year":"2019","unstructured":"Peir\u00f3 Cadah\u00eda J, Previtali V, Troelsen NS, Clausen MH (2019) Prodrug strategies for targeted therapy triggered by reactive oxygen species. MedChemComm 10(9):1531\u20131544","journal-title":"MedChemComm"},{"key":"11255_CR75","doi-asserted-by":"publisher","first-page":"17448","DOI":"10.1039\/D4RA02349H","volume":"14","author":"G Bennicia","year":"2024","unstructured":"Bennicia G, Almahasheer H, Alghrably M et al (2024) Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through Pharmacological interventions. RSC Adv 14:17448\u201317460","journal-title":"RSC Adv"},{"issue":"6","key":"11255_CR76","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1055\/s-0043-121143","volume":"68","author":"H Yaribeygi","year":"2018","unstructured":"Yaribeygi H, Mohammadi MT, Sahebkar A (2018) PPAR-\u03b1 agonist improves hyperglycemia-induced oxidative stress in pancreatic cells by potentiating antioxidant defense systems. J Drug Res 68(6):355\u2013360","journal-title":"J Drug Res"},{"issue":"1","key":"11255_CR77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.9734\/jpri\/2024\/v36i17493","volume":"36","author":"N Rais","year":"2024","unstructured":"Rais N, Ved A, Ahmad R, Parveen A (2024) Oxidative stress and diabetes mellitus: unravelling the intricate connection. J Pharm Res Int 36(1):13\u201330","journal-title":"J Pharm Res Int"},{"key":"11255_CR78","unstructured":"Naraparaju S, Malavika BV, Ramya TS (2023) In Silico ADME, bioactivity, toxicity predictions and molecular docking studies of a few antidiabetic drugs. Int J Pharm Sci. ; 3(2)"},{"issue":"19","key":"11255_CR79","doi-asserted-by":"publisher","first-page":"9376","DOI":"10.7150\/thno.64706","volume":"11","author":"Y Ding","year":"2021","unstructured":"Ding Y, Zhou Y, Ling P, Feng X, Luo S, Zheng X, Little PJ, Xu S, Weng J (2021) Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function. Theranostics 11(19):9376\u20139396","journal-title":"Theranostics"},{"key":"#cr-split#-11255_CR80.1","doi-asserted-by":"crossref","unstructured":"Vial G, Detaille D, Guigas B (2019) Role of mitochondria in the mechanism(s) of action of metformin. Front Endocrinol.","DOI":"10.3389\/fendo.2019.00294"},{"key":"#cr-split#-11255_CR80.2","doi-asserted-by":"crossref","unstructured":"10: 294. Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J. Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science. 2023. 379(6629): 351-357","DOI":"10.1126\/science.ade3332"},{"key":"11255_CR81","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.abb.2019.07.008","volume":"671","author":"X Luo","year":"2019","unstructured":"Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X (2019) Dulaglutide inhibits high glucose-induced endothelial dysfunction and NLRP3 inflammasome activation. Arch Biochem Biophys 671:203\u2013209","journal-title":"Arch Biochem Biophys"},{"issue":"17","key":"11255_CR82","doi-asserted-by":"publisher","first-page":"10245","DOI":"10.1039\/C9RA09959J","volume":"10","author":"M Xiao","year":"2020","unstructured":"Xiao M, Lu D, Tian J, Yu Y, Zhang Q, Zhang L, Chang D (2020) Protective effects of GLP-1 receptor agonist lixisenatide on oxygen-glucose deprivation\/reperfusion-induced endothelial injury. RSC Adv 10(17):10245\u201310253","journal-title":"RSC Adv"},{"issue":"1","key":"11255_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10557-020-07069-8","volume":"39","author":"X Zhang","year":"2025","unstructured":"Zhang X, Cao C, Zheng F, Liu C, Tian X (2025) Therapeutic potential of GLP-1 receptor agonists in diabetes and cardiovascular disease: mechanisms and clinical implications. Cardiovasc Drugs Ther 39(1):1\u201315","journal-title":"Cardiovasc Drugs Ther"},{"issue":"13","key":"11255_CR84","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.3390\/ijms25137274","volume":"25","author":"N Mylonas","year":"2024","unstructured":"Mylonas N, Nikolaou PE, Karakasis P, Stachteas P, Fragakis N, Andreadou I (2024) Endothelial protection by sodium-glucose cotransporter 2 inhibitors: a literature review of in vitro and in vivo studies. Int J Mol Sci 25(13):7274","journal-title":"Int J Mol Sci"},{"issue":"8","key":"11255_CR85","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/ehjcvp\/pvad053","volume":"9","author":"K Dimitriadis","year":"2023","unstructured":"Dimitriadis K, Adamopoulou E, Pyrpyris N, Sakalidis A, Leontsinis I, Konstantinidis D (2023) Effect of SGLT2 inhibitors on the endothelium and the microcirculation: from bench to bedside and beyond. Eur Heart J Cardiovasc Pharmacother 9(8):741\u2013757","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"11255_CR86","doi-asserted-by":"publisher","first-page":"112515","DOI":"10.1016\/j.biopha.2021.112515","volume":"146","author":"L Uthman","year":"2021","unstructured":"Uthman L, Li X, Baartscheer A, Schumacher CA, Baumgart P, Hermanides J et al (2021) Empagliflozin reduces oxidative stress through Inhibition of the novel inflammation\/NHE\/[Na+]c\/ROS-pathway in human endothelial cells. Biomed Pharmacother 146:112515","journal-title":"Biomed Pharmacother"},{"key":"11255_CR87","doi-asserted-by":"publisher","first-page":"1005408","DOI":"10.3389\/fcvm.2023.1005408","volume":"10","author":"T Koizumi","year":"2023","unstructured":"Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J et al (2023) Empagliflozin suppresses mitochondrial ROS generation and mitigates atrial fibrosis in diabetic rats. Front Cardiovasc Med 10:1005408","journal-title":"Front Cardiovasc Med"},{"key":"11255_CR88","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10735-024-10233-1","volume":"55","author":"CC Yang","year":"2024","unstructured":"Yang CC, Chen KH, Yue Y, Cheng BC, Hsu TW, Chiang JY et al (2024) SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal protection. J Mol Histol 55:803\u2013823","journal-title":"J Mol Histol"},{"key":"11255_CR89","doi-asserted-by":"publisher","first-page":"5119","DOI":"10.2147\/IJN.S512074","volume":"20","author":"H Wang","year":"2025","unstructured":"Wang H, Bai Z, Qiu Y, Kou J, Zhu Y, Tan Q et al (2025) Empagliflozin-pretreated MSC-derived exosomes enhance angiogenesis and wound healing via PTEN\/AKT\/VEGF pathway. Int J Nanomed 20:5119\u20135136","journal-title":"Int J Nanomed"},{"issue":"15","key":"11255_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30153112","volume":"30","author":"M Stielow","year":"2025","unstructured":"Stielow M, Fija\u0142kowski \u0141, Alaburda A, Grze\u015bk G, Grze\u015bk E, Nowaczyk J, Nowaczyk A (2025) SGLT2 inhibitors: from molecular mechanisms to clinical outcomes in cardiology and diabetology. Molecules 30(15):3112","journal-title":"Molecules"},{"key":"11255_CR91","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01325-9","volume":"16","author":"R Zhang","year":"2024","unstructured":"Zhang R, Xie Q, Lu X, Fan R, Tong N (2024) Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitus. Diabetol Metab Syndr 16:99","journal-title":"Diabetol Metab Syndr"},{"key":"11255_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1043406","volume":"9","author":"CX Yuan","year":"2022","unstructured":"Yuan CX, Zhou MQ, Zhang JH, Cheng WT, Bai XH, Lou LX (2022) Thiazolidinediones play a positive role in the vascular endothelium and inhibit plaque progression in diabetic patients with coronary atherosclerosis: a systematic review and meta-analysis. Front Cardiovasc Med 9:1043406","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"11255_CR93","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/FJC.0000000000000143","volume":"64","author":"P Wang","year":"2014","unstructured":"Wang P, Li B, Cai G, Huang M, Jiang L, Zhou P (2014) Activation of PPAR-\u03b3 by Pioglitazone attenuates oxidative stress in aging rat cerebral arteries through upregulating UCP2. J Cardiovasc Pharmacol 64(6):497\u2013506","journal-title":"J Cardiovasc Pharmacol"},{"key":"11255_CR94","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/toxsci\/kfu015","volume":"138","author":"H He","year":"2014","unstructured":"He H, Tao H, Xiong H, Duan SZ, McGowan FX, Mortensen RM (2014) Rosiglitazone causes cardiotoxicity via PPAR\u03b3-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci 138:468\u2013481","journal-title":"Toxicol Sci"},{"key":"11255_CR95","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1039\/D4BM00349G","volume":"12","author":"Y Majie","year":"2024","unstructured":"Majie Y, Roy A, Das B et al (2024) Clerodendrum glandulosum\u2013silver nanoparticle hydrogel for diabetic wound healing: image-guided machine learning validation. Biomater Sci 12:4567\u20134582","journal-title":"Biomater Sci"},{"key":"11255_CR96","first-page":"103544","volume":"34","author":"A Roy","year":"2025","unstructured":"Roy A, Majie Y, Das B et al (2025) Phytochemical\u2013silver nanoparticle hybrid hydrogel for diabetic wound healing: ROS modulation and bioengineered delivery. Biochem Biophys Rep 34:103544","journal-title":"Biochem Biophys Rep"},{"key":"11255_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126639","volume":"62","author":"F Imanparast","year":"2020","unstructured":"Imanparast F, Mashayekhi FJ, Kamankesh F, Rafiei F, Mohaghegh P, Alimoradian A (2020) Improving endothelial dysfunction in type 2 diabetes with chromium and vitamin D3 by reducing homocysteine and oxidative stress: a randomized placebo-controlled trial. J Trace Elem Med Biol 62:126639","journal-title":"J Trace Elem Med Biol"},{"key":"11255_CR98","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1714896","volume":"2018","author":"M Zhang","year":"2018","unstructured":"Zhang M, Lin L, Xu C, Chai D, Peng F, Lin J (2018) VDR agonist prevents diabetic endothelial dysfunction through inhibition of prolyl isomerase-1-mediated mitochondrial oxidative stress and inflammation. Oxid Med Cell Longev 2018:1714896","journal-title":"Oxid Med Cell Longev"},{"key":"11255_CR99","doi-asserted-by":"crossref","unstructured":"Park HS, Lim JH, Kim MY et al (2016) Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy. J Transl Med. ;14:176. e","DOI":"10.1186\/s12967-016-0922-9"},{"issue":"7","key":"11255_CR100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001603","volume":"11","author":"K Higashida","year":"2013","unstructured":"Higashida K, Kim SH, Jung SR et al (2013) Effects of resveratrol and SIRT1 on PGC-1\u03b1 activity and mitochondrial biogenesis: a re-evaluation. PLoS Biol 11(7):e1001603","journal-title":"PLoS Biol"},{"key":"11255_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-017-0217-z","volume":"14","author":"X Zhu","year":"2017","unstructured":"Zhu X, Wu C, Qiu S et al (2017) Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab 14:60","journal-title":"Nutr Metab"},{"key":"11255_CR102","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/md12010128","volume":"12","author":"RR Ambati","year":"2014","unstructured":"Ambati RR, Phang SM, Ravi S, Aswathanarayana RG (2014) Astaxanthin: sources, extraction, stability, biological activities and its commercial applications\u2014a review. Mar Drugs 12:128\u2013152","journal-title":"Mar Drugs"},{"key":"11255_CR103","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1038\/s41598-020-75025-5","volume":"10","author":"Y Nishida","year":"2020","unstructured":"Nishida Y, Nawaz A, Kado T et al (2020) Astaxanthin stimulates mitochondrial biogenesis in insulin-resistant muscle via activation of AMPK pathway. Sci Rep 10:5714","journal-title":"Sci Rep"},{"key":"11255_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-46401-5_1","volume":"595","author":"BB Aggarwal","year":"2007","unstructured":"Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007) Curcumin: the Indian solid gold. Adv Exp Med Biol 595:1\u201375","journal-title":"Adv Exp Med Biol"},{"key":"11255_CR105","first-page":"581","volume":"66","author":"Y Panahi","year":"2016","unstructured":"2, Panahi Y, Khalili N, Sahebi E et al (2016) Antioxidant and anti-inflammatory effects of curcuminoid\u2013piperine combination in patients with metabolic syndrome: a randomized controlled trial. Drug Res 66:581\u2013586","journal-title":"Drug Res"},{"key":"11255_CR106","first-page":"104","volume":"146","author":"Y Yagishita","year":"2019","unstructured":"Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW (2019) Broccoli or sulforaphane: is it the source or dose that matters? Pharmacol Res 146:104\u2013119","journal-title":"Pharmacol Res"},{"key":"11255_CR107","first-page":"1","volume":"201","author":"Y Bai","year":"2023","unstructured":"Bai Y, Wang X, Zhao S et al (2023) Sulforaphane protects against diabetic wound delay by activating Nrf2 and suppressing NF-\u03baB signaling in human microvascular endothelial cells. Free Radic Biol Med 201:1\u201313","journal-title":"Free Radic Biol Med"},{"key":"11255_CR108","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae084","volume":"13","author":"S Zhao","year":"2025","unstructured":"Zhao S, Hu X, Zhao Y et al (2025) Hydrogel-based therapies for diabetic foot ulcers: recent developments and clinical implications. Burns Trauma 13:tkae084","journal-title":"Burns Trauma"},{"issue":"33","key":"11255_CR109","doi-asserted-by":"publisher","first-page":"202400489","DOI":"10.1002\/adfm.202400489","volume":"34","author":"X Qi","year":"2024","unstructured":"Qi X, Ge X, Chen X et al (2024) An immunoregulation hydrogel with controlled hyperthermia-augmented oxygenation and ROS scavenging for treating diabetic foot ulcers. Adv Funct Mater 34(33):202400489","journal-title":"Adv Funct Mater"},{"key":"11255_CR110","volume":"10","author":"Y Chen","year":"2023","unstructured":"Chen Y, Wang X, Tao S et al (2023) Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties. Mil Med Res 10:37","journal-title":"Mil Med Res"},{"key":"11255_CR111","doi-asserted-by":"publisher","first-page":"e202500720","DOI":"10.1002\/advs.202500720","volume":"12","author":"Y Shen","year":"2025","unstructured":"Shen Y, Li S, Hou X et al (2025) Ultrasound-triggered nanocomposite lever hydrogels with a full repair system accelerate diabetic foot ulcer repair. Adv Sci 12:e202500720","journal-title":"Adv Sci"},{"issue":"4","key":"11255_CR112","doi-asserted-by":"publisher","DOI":"10.3390\/polym14040687","volume":"14","author":"A Rinaldi","year":"2022","unstructured":"Rinaldi A, Caraffi R, Grazioli MV et al (2022) Applications of the ROS-responsive thioketal linker for the production of smart nanomedicines. Polymers 14(4):687","journal-title":"Polymers"},{"key":"11255_CR113","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1007\/s13346-022-01116-7","volume":"12","author":"Z Davoodi","year":"2022","unstructured":"Davoodi Z, Shafiee F (2022) Internalizing RGD: a great motif for targeted peptide and protein delivery. Drug Deliv Transl Res 12:2261\u20132274","journal-title":"Drug Deliv Transl Res"},{"key":"11255_CR114","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03623-4","volume":"23","author":"Y Mao","year":"2025","unstructured":"Mao Y, Xu S, Shi X et al (2025) Bioengineered microneedles and nanomedicine as therapeutic platform for tissue regeneration. J Nanobiotechnology 23:573","journal-title":"J Nanobiotechnology"},{"issue":"12","key":"11255_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121866","volume":"58","author":"S Vuj\u010di\u0107","year":"2022","unstructured":"Vuj\u010di\u0107 S, Kotur-Stevuljevi\u0107 J, Veki\u0107 J et al (2022) Oxidative stress and inflammatory biomarkers in patients with diabetic foot. Medicina (B Aires) 58(12):1866","journal-title":"Medicina (B Aires)"},{"key":"11255_CR116","doi-asserted-by":"crossref","unstructured":"Niewczas MA, Shah H (2024) Biomarkers of diabetic foot ulcers and its healing progress. The diabetic foot. Springer, pp 327\u2013338","DOI":"10.1007\/978-3-031-55715-6_18"},{"key":"11255_CR117","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-025-00672-5","volume":"20","author":"J Lin","year":"2025","unstructured":"Lin J, Huang L, Li W, Xiao H, Pan M (2025) Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data. Biol Direct 20:79","journal-title":"Biol Direct"},{"issue":"11","key":"11255_CR118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113743","volume":"21","author":"M Graille","year":"2020","unstructured":"Graille M, Wild P, Sauvain J-J et al (2020) Urinary 8-OHdG as a biomarker for oxidative stress: a systematic literature review and meta-analysis. Int J Mol Sci 21(11):3743","journal-title":"Int J Mol Sci"},{"issue":"8","key":"11255_CR119","first-page":"4438","volume":"15","author":"R Arora","year":"2025","unstructured":"Arora R, Dhaliwal J, Dhaliwal N et al (2025) Topical application of phycocyanin accelerates wound healing in STZ-induced diabetic rats via activation of the Nrf2 signaling pathway. J Biotechnol 15(8):4438","journal-title":"J Biotechnol"},{"key":"11255_CR120","doi-asserted-by":"crossref","unstructured":"Ranjan S, Singh A, Yadav R (2025) Artificial intelligence in precision medicine and Patient-Specific drug design. Biomed Pharmacol J. ;18(March Special Edition).","DOI":"10.13005\/bpj\/3088"},{"key":"11255_CR121","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2024.1336050","volume":"6","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Qin G, Aguilar B et al (2024) A framework towards digital twins for type 2 diabetes. Front Digit Health 6:1336050","journal-title":"Front Digit Health"},{"key":"11255_CR122","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf020","volume":"13","author":"R Wang","year":"2025","unstructured":"Wang R, Li B, Dong M et al (2025) Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies. Burns Trauma 13:tkaf020","journal-title":"Burns Trauma"},{"key":"11255_CR123","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-024-01210-6","volume":"23","author":"R Basiri","year":"2024","unstructured":"Basiri R, Manji K, LeLievre PM et al (2024) Protocol for metadata and image collection at diabetic foot ulcer clinics: enabling research in wound analytics and deep learning. Biomed Eng Online 23:12","journal-title":"Biomed Eng Online"},{"key":"11255_CR124","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/iwj.13603","volume":"19","author":"KS Chan","year":"2022","unstructured":"Chan KS, Chan YM, Tan AHM et al (2022) Clinical validation of an artificial intelligence-enabled wound imaging mobile application in diabetic foot ulcers. Int Wound J 19:114\u2013124","journal-title":"Int Wound J"},{"issue":"24","key":"11255_CR125","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13247655","volume":"13","author":"O Ganesan","year":"2024","unstructured":"Ganesan O, Orgill DP (2024) An overview of recent clinical trials for diabetic foot ulcer therapies. J Clin Med 13(24):7655","journal-title":"J Clin Med"},{"issue":"6","key":"11255_CR126","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13060648","volume":"13","author":"S Alkhalefah","year":"2025","unstructured":"Alkhalefah S, AlTuraiki I, Altwaijry N (2025) Advancing diabetic foot ulcer care: AI and generative AI approaches for classification, prediction, segmentation, and detection. Healthcare 13(6):648","journal-title":"Healthcare"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11255-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11255-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11255-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:07:07Z","timestamp":1763640427000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11255-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":127,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11255"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11255-y","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"5 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"107"}}