{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:29:33Z","timestamp":1784946573479,"version":"3.55.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11270-z","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:22:16Z","timestamp":1764134536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extracellular vesicles derived from dental mesenchymal stem cells for regenerative medicine: a scoping review"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-4296","authenticated-orcid":false,"given":"Maria Em\u00edlia","family":"Mota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-1252","authenticated-orcid":false,"given":"M\u00e1rcia Martins","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-0370","authenticated-orcid":false,"given":"Tha\u00eds","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-3336","authenticated-orcid":false,"given":"Suely Kunimi Kubo","family":"Ariga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-7413","authenticated-orcid":false,"given":"Tiago G\u00f3ss dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1536","authenticated-orcid":false,"given":"F\u00e1bio Abreu","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-4544","authenticated-orcid":false,"given":"Maria Stella","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"11270_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","volume":"52","author":"DE Rodr\u00edguez-Fuentes","year":"2021","unstructured":"Rodr\u00edguez-Fuentes DE, Fern\u00e1ndez-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Salda\u00f1a HA (2021) Mesenchymal stem cells current clinical applications: a systematic review. Arch Med Res 52:93\u2013101. https:\/\/doi.org\/10.1016\/j.arcmed.2020.08.006","journal-title":"Arch Med Res"},{"key":"11270_CR2","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.jconrel.2023.11.057","volume":"365","author":"C Yang","year":"2024","unstructured":"Yang C, Xue Y, Duan Y, Mao C, Wan M (2024) Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications. J Control Release 365:1089\u20131123. https:\/\/doi.org\/10.1016\/j.jconrel.2023.11.057","journal-title":"J Control Release"},{"key":"11270_CR3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/JLB.3MR0321-766R","volume":"110","author":"L Shang","year":"2021","unstructured":"Shang L, Shao J, Ge S (2021) Immunomodulatory functions of oral mesenchymal stem cells: novel force for tissue regeneration and disease therapy. J Leukoc Biol 110:539\u2013552. https:\/\/doi.org\/10.1002\/JLB.3MR0321-766R","journal-title":"J Leukoc Biol"},{"key":"11270_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mocell.2024.100151","volume":"47","author":"H Jung","year":"2024","unstructured":"Jung H, Jung Y, Seo J, Bae Y, Kim H-S, Jeong W (2024) Roles of extracellular vesicles from mesenchymal stem cells in regeneration. Mol Cells 47:100151. https:\/\/doi.org\/10.1016\/j.mocell.2024.100151","journal-title":"Mol Cells"},{"key":"11270_CR5","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI, Blenkiron C, Bussolati B et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles 13:e12404. https:\/\/doi.org\/10.1002\/jev2.12404","journal-title":"J Extracell Vesicles"},{"key":"11270_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01735-1","volume":"9","author":"MA Kumar","year":"2024","unstructured":"Kumar MA, Baba SK, Sadida HQ, Marzooqi SA, Jerobin J, Altemani FH et al (2024) Extracellular vesicles as tools and targets in therapy for diseases. Signal Transduct Target Ther 9:27. https:\/\/doi.org\/10.1038\/s41392-024-01735-1","journal-title":"Signal Transduct Target Ther"},{"key":"11270_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0223-5","volume":"1","author":"DE Murphy","year":"2019","unstructured":"Murphy DE, de Jong OG, Brouwer M, Wood MJ, Lavieu G, Schiffelers RM et al (2019) Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking. Exp Mol Med 1:32. https:\/\/doi.org\/10.1038\/s12276-019-0223-5","journal-title":"Exp Mol Med"},{"key":"11270_CR8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12026-019-09088-6","volume":"67","author":"L Ji","year":"2019","unstructured":"Ji L, Bao L, Gu Z, Zhou Q, Liang Y, Zheng Y et al (2019) Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells. Immunol Res 67:432\u2013442. https:\/\/doi.org\/10.1007\/s12026-019-09088-6","journal-title":"Immunol Res"},{"key":"11270_CR9","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3389\/fphys.2017.00904","volume":"8","author":"Q Shi","year":"2017","unstructured":"Shi Q, Qian Z, Liu D, Sun J, Wang X, Liu H et al (2017) GMSC-derived exosomes combined with a chitosan\/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model. Front Physiol 8:904. https:\/\/doi.org\/10.3389\/fphys.2017.00904","journal-title":"Front Physiol"},{"key":"11270_CR10","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1002\/stem.2618","volume":"35","author":"H Gonzalez-King","year":"2017","unstructured":"Gonzalez-King H, Garc\u00eda NA, Ontoria-Oviedo I, Ciria M, Montero JA, Sep\u00falveda P (2017) Hypoxia inducible factor-1\u03b1 potentiates Jagged 1-mediated angiogenesis by mesenchymal stem cell-derived exosomes. Stem Cells 35:1747\u20131759. https:\/\/doi.org\/10.1002\/stem.2618","journal-title":"Stem Cells"},{"key":"11270_CR11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13287-017-0648-5","volume":"8","author":"Y Li","year":"2017","unstructured":"Li Y, Yang Y-Y, Ren J-L, Xu F, Chen F-M, Li A (2017) Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1\/M2 polarization in rats. Stem Cell Res Ther 8:198. https:\/\/doi.org\/10.1186\/s13287-017-0648-5","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2546367","volume":"2019","author":"F Rao","year":"2019","unstructured":"Rao F, Zhang D, Fang T, Lu C, Wang B, Ding X et al (2019) Exosomes from human gingiva-derived mesenchymal stem cells combined with biodegradable chitin conduits promote rat sciatic nerve regeneration. Stem Cells Int 2019:1\u201312. https:\/\/doi.org\/10.1155\/2019\/2546367","journal-title":"Stem Cells Int"},{"key":"11270_CR13","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1021\/acsbiomaterials.9b00607","volume":"5","author":"J Wu","year":"2019","unstructured":"Wu J, Chen L, Wang R, Song Z, Shen Z, Zhao Y et al (2019) Exosomes secreted by stem cells from human exfoliated deciduous teeth promote alveolar bone defect repair through the regulation of angiogenesis and osteogenesis. ACS Biomater Sci Eng 5:3561\u20133571. https:\/\/doi.org\/10.1021\/acsbiomaterials.9b00607","journal-title":"ACS Biomater Sci Eng"},{"key":"11270_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0022034518804531","volume":"98","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Shi S, Xu Q, Zhang Q, Shanti RM, Le AD (2019) SIS-ECM laden with GMSC-derived exosomes promote taste bud regeneration. J Dent Res 98:225\u2013233. https:\/\/doi.org\/10.1177\/0022034518804531","journal-title":"J Dent Res"},{"key":"11270_CR15","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.bioactmat.2020.07.002","volume":"5","author":"Z Shen","year":"2020","unstructured":"Shen Z, Kuang S, Zhang Y, Yang M, Qin W, Shi X et al (2020) Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism. Bioact Mater 5:1113\u201326. https:\/\/doi.org\/10.1016\/j.bioactmat.2020.07.002","journal-title":"Bioact Mater"},{"key":"11270_CR16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.actbio.2020.09.052","volume":"118","author":"WB Swanson","year":"2020","unstructured":"Swanson WB, Zhang Z, Xiu K, Gong T, Eberle M, Wang Z et al (2020) Scaffolds with controlled release of pro-mineralization exosomes to promote craniofacial bone healing without cell transplantation. Acta Biomater 118:215\u201332. https:\/\/doi.org\/10.1016\/j.actbio.2020.09.052","journal-title":"Acta Biomater"},{"key":"11270_CR17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jconrel.2020.06.006","volume":"324","author":"WB Swanson","year":"2020","unstructured":"Swanson WB, Gong T, Zhang Z, Eberle M, Niemann D, Dong R et al (2020) Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy. J Control Release 324:679\u201394. https:\/\/doi.org\/10.1016\/j.jconrel.2020.06.006","journal-title":"J Control Release"},{"key":"11270_CR18","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1021\/acsbiomaterials.0c00882","volume":"6","author":"W Shi","year":"2020","unstructured":"Shi W, Guo S, Liu L, Liu Q, Huo F, Ding Y et al (2020) Small extracellular vesicles from lipopolysaccharide-preconditioned dental follicle cells promote periodontal regeneration in an inflammatory microenvironment. ACS Biomater Sci Eng 6:5797\u20135810. https:\/\/doi.org\/10.1021\/acsbiomaterials.0c00882","journal-title":"ACS Biomater Sci Eng"},{"key":"11270_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1186\/s13287-020-02039-1","volume":"11","author":"J Zheng","year":"2020","unstructured":"Zheng J, Kong Y, Hu X, Li Z, Li Y, Zhong Y et al (2020) MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis. Stem Cell Res Ther 11:517. https:\/\/doi.org\/10.1186\/s13287-020-02039-1","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbrc.2021.08.046","volume":"575","author":"J Dong","year":"2021","unstructured":"Dong J, Sakai K, Koma Y, Watanabe J, Liu K, Maruyama H et al (2021) Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence. Biochem Biophys Res Commun 575:28\u201335. https:\/\/doi.org\/10.1016\/j.bbrc.2021.08.046","journal-title":"Biochem Biophys Res Commun"},{"key":"11270_CR21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.2147\/IJN.S350869","volume":"17","author":"Y Huang","year":"2022","unstructured":"Huang Y, Liu Q, Liu L, Huo F, Guo S, Tian W (2022) Lipopolysaccharide-preconditioned dental follicle stem cells derived small extracellular vesicles treating periodontitis via reactive oxygen species\/mitogen-activated protein kinase signaling-mediated antioxidant effect. Int J Nanomed 17:799\u2013819. https:\/\/doi.org\/10.2147\/IJN.S350869","journal-title":"Int J Nanomed"},{"key":"11270_CR22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13287-021-02151-w","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zhuang X, Yu S, Yang N, Zeng J, Liu X et al (2021) Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization. Stem Cell Res Ther 12:76. https:\/\/doi.org\/10.1186\/s13287-021-02151-w","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","volume":"122","author":"Y Nakao","year":"2021","unstructured":"Nakao Y, Fukuda T, Zhang Q, Sanui T, Shinjo T, Kou X et al (2021) Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater 122:306\u201324. https:\/\/doi.org\/10.1016\/j.actbio.2020.12.046","journal-title":"Acta Biomater"},{"key":"11270_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.128040","volume":"417","author":"W Yu","year":"2021","unstructured":"Yu W, Su X, Li M, Wan W, Li A, Zhou H et al (2021) Three-dimensional mechanical microenvironment enhanced osteogenic activity of mesenchymal stem cells-derived exosomes. Chem Eng J 417:128040. https:\/\/doi.org\/10.1016\/j.cej.2020.128040","journal-title":"Chem Eng J"},{"key":"11270_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.joen.2020.11.017","volume":"47","author":"B Wen","year":"2021","unstructured":"Wen B, Huang Y, Qiu T, Huo F, Xie L, Liao L et al (2021) Reparative dentin formation by dentin matrix proteins and small extracellular vesicles. J Endod 47:253\u201362. https:\/\/doi.org\/10.1016\/j.joen.2020.11.017","journal-title":"J Endod"},{"key":"11270_CR26","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.joen.2021.03.010","volume":"47","author":"W-J Chen","year":"2021","unstructured":"Chen W-J, Xie J, Lin X, Ou M-H, Zhou J, Wei X-L et al (2021) The role of small extracellular vesicles derived from Lipopolysaccharide-preconditioned human dental pulp stem cells in dental pulp regeneration. J Endod 47:961\u20139. https:\/\/doi.org\/10.1016\/j.joen.2021.03.010","journal-title":"J Endod"},{"key":"11270_CR27","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13287-022-02767-6","volume":"13","author":"L Ma","year":"2022","unstructured":"Ma L, Rao N, Jiang H, Dai Y, Yang S, Yang H et al (2022) Small extracellular vesicles from dental follicle stem cells provide biochemical cues for periodontal tissue regeneration. Stem Cell Res Ther 13:92. https:\/\/doi.org\/10.1186\/s13287-022-02767-6","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3892\/ijmm.2022.5199","volume":"50","author":"Z Zhou","year":"2022","unstructured":"Zhou Z, Zheng J, Lin D, Xu R, Chen Y, Hu X (2022) Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42\/p38 MAPK pathway. Int J Mol Med 50:143. https:\/\/doi.org\/10.3892\/ijmm.2022.5199","journal-title":"Int J Mol Med"},{"key":"11270_CR29","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.bioactmat.2022.01.041","volume":"14","author":"Y Gao","year":"2022","unstructured":"Gao Y, Yuan Z, Yuan X, Wan Z, Yu Y, Zhan Q et al (2022) Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration. Bioact Mater 14:377\u201388. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.01.041","journal-title":"Bioact Mater"},{"key":"11270_CR30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.actbio.2021.12.035","volume":"141","author":"F Lei","year":"2022","unstructured":"Lei F, Li M, Lin T, Zhou H, Wang F, Su X (2022) Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes. Acta Biomater 141:333\u2013343. https:\/\/doi.org\/10.1016\/j.actbio.2021.12.035","journal-title":"Acta Biomater"},{"key":"11270_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13287-022-02764-9","volume":"13","author":"P Liu","year":"2022","unstructured":"Liu P, Zhang Q, Mi J, Wang S, Xu Q, Zhuang D et al (2022) Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246. Stem Cell Res Ther 13:89. https:\/\/doi.org\/10.1186\/s13287-022-02764-9","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR32","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1021\/acsami.2c02278","volume":"14","author":"X Jing","year":"2022","unstructured":"Jing X, Wang S, Tang H, Li D, Zhou F, Xin L et al (2022) Dynamically bioresponsive DNA hydrogel incorporated with dual-functional stem cells from apical Papilla-Derived exosomes promotes diabetic bone regeneration. ACS Appl Mater Interfaces 14:16082\u201316099. https:\/\/doi.org\/10.1021\/acsami.2c02278","journal-title":"ACS Appl Mater Interfaces"},{"key":"11270_CR33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12951-022-01446-1","volume":"20","author":"Y Xie","year":"2022","unstructured":"Xie Y, Yu L, Cheng Z, Peng Y, Cao Z, Chen B et al (2022) Shed-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. J Nanobiotechnol 20:239. https:\/\/doi.org\/10.1186\/s12951-022-01446-1","journal-title":"J Nanobiotechnol"},{"key":"11270_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13324","volume":"55","author":"J Guo","year":"2022","unstructured":"Guo J, Zhou F, Liu Z, Cao Y, Zhao W, Zhang Z et al (2022) Exosome-shuttled mitochondrial transcription factor A mRNA promotes the osteogenesis of dental pulp stem cells through mitochondrial oxidative phosphorylation activation. Cell Prolif 55:e13324. https:\/\/doi.org\/10.1111\/cpr.13324","journal-title":"Cell Prolif"},{"key":"11270_CR35","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.3390\/pharmaceutics14102189","volume":"14","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Gong Y, Liu X, He J, Zheng B, Liu Y (2022) The experimental study of periodontal ligament stem cells derived exosomes with hydrogel accelerating bone regeneration on alveolar bone defect. Pharmaceutics 14:2189. https:\/\/doi.org\/10.3390\/pharmaceutics14102189","journal-title":"Pharmaceutics"},{"key":"11270_CR36","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2147\/IJN.S346755","volume":"17","author":"B Zhao","year":"2022","unstructured":"Zhao B, Chen Q, Zhao L, Mao J, Huang W, Han X et al (2022) Periodontal ligament stem Cell-Derived small extracellular vesicles embedded in matrigel enhance bone repair through the adenosine receptor signaling pathway. Int J Nanomed 17:519\u2013536. https:\/\/doi.org\/10.2147\/IJN.S346755","journal-title":"Int J Nanomed"},{"key":"11270_CR37","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/iej.13721","volume":"55","author":"S Yu","year":"2022","unstructured":"Yu S, Chen X, Liu Y, Zhuang XY, Wang AC, Liu XM et al (2022) Exosomes derived from stem cells from the apical papilla alleviate inflammation in rat pulpitis by upregulating regulatory T cells. Int Endod J 55:517\u2013530. https:\/\/doi.org\/10.1111\/iej.13721","journal-title":"Int Endod J"},{"key":"11270_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.879877","author":"P Liu","year":"2022","unstructured":"Liu P, Qin L, Liu C, Mi J, Zhang Q, Wang S et al (2022) Exosomes derived from hypoxia-conditioned stem cells of human deciduous exfoliated teeth enhance angiogenesis via the transfer of let-7f-5p and miR-210-3p. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2022.879877","journal-title":"Front Cell Dev Biol"},{"key":"11270_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2022.112646","volume":"133","author":"W Yu","year":"2022","unstructured":"Yu W, Li S, Guan X, Zhang N, Xie X, Zhang K et al (2022) Higher yield and enhanced therapeutic effects of exosomes derived from MSCs in hydrogel-assisted 3D culture system for bone regeneration. Biomaterials Advances 133:112646. https:\/\/doi.org\/10.1016\/j.msec.2022.112646","journal-title":"Biomaterials Advances"},{"key":"11270_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211602","volume":"35","author":"S Jin","year":"2023","unstructured":"Jin S, Wang Y, Wu X, Li Z, Zhu L, Niu Y et al (2023) Young exosome bio-nanoparticles restore aging\u2010impaired tendon stem\/progenitor cell function and reparative capacity. Adv Mater 35:e2211602. https:\/\/doi.org\/10.1002\/adma.202211602","journal-title":"Adv Mater"},{"key":"11270_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/6625123","volume":"2023","author":"E Mao","year":"2023","unstructured":"Mao E, Hu Y, Xin Y, Sun Z, Zhang J, Li S (2023) Human dental follicle cell-derived small extracellular vesicles attenuate temporomandibular joint cartilage damage through inhibiting HIF-2\u03b1. J Tissue Eng Regen Med 2023:1\u201319. https:\/\/doi.org\/10.1155\/2023\/6625123","journal-title":"J Tissue Eng Regen Med"},{"key":"11270_CR42","doi-asserted-by":"publisher","first-page":"5327","DOI":"10.2147\/IJN.S409664","volume":"18","author":"J Lu","year":"2023","unstructured":"Lu J, Yu N, Liu Q, Xie Y, Zhen L (2023) Periodontal ligament stem cell exosomes key to regulate periodontal regeneration by miR-31-5p in mice model. Int J Nanomed 18:5327\u20135342. https:\/\/doi.org\/10.2147\/IJN.S409664","journal-title":"Int J Nanomed"},{"key":"11270_CR43","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.2147\/IJN.S420967","volume":"18","author":"X Qiao","year":"2023","unstructured":"Qiao X, Tang J, Dou L, Yang S, Sun Y, Mao H et al (2023) Dental pulp stem Cell-Derived exosomes regulate anti-inflammatory and osteogenesis in periodontal ligament stem cells and promote the repair of experimental periodontitis in rats. Int J Nanomedicine 18:4683\u2013703. https:\/\/doi.org\/10.2147\/IJN.S420967","journal-title":"Int J Nanomedicine"},{"key":"11270_CR44","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.3390\/ijms24054926","volume":"24","author":"Y Fu","year":"2023","unstructured":"Fu Y, Cui S, Zhou Y, Qiu L (2023) Dental pulp stem cell-derived exosomes alleviate mice knee osteoarthritis by inhibiting TRPV4-mediated osteoclast activation. Int J Mol Sci 24:4926. https:\/\/doi.org\/10.3390\/ijms24054926","journal-title":"Int J Mol Sci"},{"key":"11270_CR45","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1039\/d2na00762b","volume":"5","author":"Z Liu","year":"2023","unstructured":"Liu Z, Yang S, Li X, Wang S, Zhang T, Huo N et al (2023) Local transplantation of GMSC-derived exosomes to promote vascularized diabetic wound healing by regulating the Wnt\/\u03b2-catenin pathways. Nanoscale Adv 5:916\u2013926. https:\/\/doi.org\/10.1039\/d2na00762b","journal-title":"Nanoscale Adv"},{"key":"11270_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.141488","volume":"458","author":"R Wang","year":"2023","unstructured":"Wang R, Liao L, Huang X, Ma S, Wang S, Qiao H et al (2023) Mechano-responsive microRNA-functionalized PDLSC exosomes as a novel therapeutic for inflammatory bone loss in periodontitis. Chem Eng J 458:141488. https:\/\/doi.org\/10.1016\/j.cej.2023.141488","journal-title":"Chem Eng J"},{"key":"11270_CR47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.2217\/rme-2022-0206","volume":"18","author":"X Shi","year":"2023","unstructured":"Shi X, Yang G, Liu M, Yuan M, Wang D, Wang X (2023) Exosomes derived from human dental pulp stem cells increase flap survival with ischemia-reperfusion injuries. Regen Med 18:313\u2013327. https:\/\/doi.org\/10.2217\/rme-2022-0206","journal-title":"Regen Med"},{"key":"11270_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2023.106869","volume":"36","author":"M Isik","year":"2023","unstructured":"Isik M, Vargel I, Ozgur E, Cam SB, Korkusuz P, Emregul E et al (2023) Human periodontal ligament stem cells-derived exosomes-loaded hybrid hydrogel enhances the calvarial defect regeneration in middle-age rats. Mater Today Commun 36:106869. https:\/\/doi.org\/10.1016\/j.mtcomm.2023.106869","journal-title":"Mater Today Commun"},{"key":"11270_CR49","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/jre.13262","volume":"59","author":"T Yu","year":"2024","unstructured":"Yu T, Mi N, Song Y, Xie W (2024) Exosomes miR-92a\u20103p from human exfoliated deciduous teeth inhibits periodontitis progression via the KLF4\/PI3K\/AKT pathway. J Periodontal Res 59:771\u2013782. https:\/\/doi.org\/10.1111\/jre.13262","journal-title":"J Periodontal Res"},{"key":"11270_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116073","volume":"222","author":"Y-F Nie","year":"2024","unstructured":"Nie Y-F, Shang J-M, Liu D-Q, Meng W-Q, Ren H-P, Li C-H et al (2024) Apical papilla stem cell-derived exosomes regulate lipid metabolism and alleviate inflammation in the MCD-induced mouse NASH model. Biochem Pharmacol 222:116073. https:\/\/doi.org\/10.1016\/j.bcp.2024.116073","journal-title":"Biochem Pharmacol"},{"key":"11270_CR51","doi-asserted-by":"publisher","first-page":"6175","DOI":"10.1007\/s12035-024-03960-9","volume":"61","author":"Y Chai","year":"2024","unstructured":"Chai Y, Liu Y, Liu Z, Wei W, Dong Y, Yang C et al (2024) Study on the role and mechanism of exosomes derived from dental pulp stem cells in promoting regeneration of myelin sheath in rats with sciatic nerve injury. Mol Neurobiol 61:6175\u20136188. https:\/\/doi.org\/10.1007\/s12035-024-03960-9","journal-title":"Mol Neurobiol"},{"key":"11270_CR52","doi-asserted-by":"publisher","first-page":"8751","DOI":"10.2147\/IJN.S470419","volume":"19","author":"Q Niu","year":"2024","unstructured":"Niu Q, Lin C, Yang S, Rong S, Wei J, Zhao T et al (2024) FoxO1-Overexpressed small extracellular vesicles derived from hPDLSCs promote periodontal tissue regeneration by reducing mitochondrial dysfunction to regulate osteogenesis and inflammation. Int J Nanomed 19:8751\u20138768. https:\/\/doi.org\/10.2147\/IJN.S470419","journal-title":"Int J Nanomed"},{"key":"11270_CR53","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13287-019-1278-x","volume":"10","author":"X Hu","year":"2019","unstructured":"Hu X, Zhong Y, Kong Y, Chen Y, Feng J, Zheng J (2019) Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGF\u03b21\/smads signaling pathway via transfer of MicroRNAs. Stem Cell Res Ther 10:170. https:\/\/doi.org\/10.1186\/s13287-019-1278-x","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR54","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13287-018-0791-7","volume":"9","author":"S Keshtkar","year":"2018","unstructured":"Keshtkar S, Azarpira N, Ghahremani MH (2018) Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther 9:63. https:\/\/doi.org\/10.1186\/s13287-018-0791-7","journal-title":"Stem Cell Res Ther"},{"key":"11270_CR55","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/2187392","author":"X Ning","year":"2024","unstructured":"Ning X, Liu R, Huang Y, Huang Z, Li H, Li Q et al (2024) Dental stem cell-derived exosomes: a review of their isolation, classification, functions, and mechanisms. Stem Cells Int. https:\/\/doi.org\/10.1155\/2024\/2187392","journal-title":"Stem Cells Int"},{"key":"11270_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-025-00370-y","author":"P Ahmad","year":"2025","unstructured":"Ahmad P, Estrin N, Farshidfar N, Zhang Y, Miron RJ (2025) Isolation methods of exosomes derived from dental stem cells. Int J Oral Sci. https:\/\/doi.org\/10.1038\/s41368-025-00370-y","journal-title":"Int J Oral Sci"},{"key":"11270_CR57","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad059","author":"A Olaechea","year":"2023","unstructured":"Olaechea A, Benabdellah K, Vergara-Buenaventura A, G\u00f3mez-Melero S, Cafferata EA, Meza-Mauricio J et al (2023) Preclinical evidence for the use of oral mesenchymal stem cell-derived extracellular vesicles in bone regenerative therapy: a systematic review. Stem Cells Transl Med. https:\/\/doi.org\/10.1093\/stcltm\/szad059","journal-title":"Stem Cells Transl Med"},{"key":"11270_CR58","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","volume":"169","author":"AC Tricco","year":"2018","unstructured":"Tricco AC, Lillie E, Zarin W, O\u2019Brien KK, Colquhoun H, Levac D et al (2018) PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 169:467\u2013473. https:\/\/doi.org\/10.7326\/M18-0850","journal-title":"Ann Intern Med"},{"key":"11270_CR59","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/1364557032000119616","volume":"8","author":"H Arksey","year":"2005","unstructured":"Arksey H, O\u2019Malley L (2005) Scoping studies: towards a methodological framework. Int J Soc Res Methodol 8:19\u201332","journal-title":"Int J Soc Res Methodol"},{"key":"11270_CR60","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/XEB.0000000000000050","volume":"13","author":"MDJ Peters","year":"2015","unstructured":"Peters MDJ, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB (2015) Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc 13:141\u2013146. https:\/\/doi.org\/10.1097\/XEB.0000000000000050","journal-title":"Int J Evid Based Healthc"},{"key":"11270_CR61","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1089\/scd.2019.0277","volume":"29","author":"A Wang","year":"2020","unstructured":"Wang A, Liu J, Zhuang X, Yu S, Zhu S, Liu Y et al (2020) Identification and comparison of piRNA expression profiles of exosomes derived from human stem cells from the apical papilla and bone marrow mesenchymal stem cells. Stem Cells Dev 29:511\u201320. https:\/\/doi.org\/10.1089\/scd.2019.0277","journal-title":"Stem Cells Dev"},{"key":"11270_CR62","doi-asserted-by":"publisher","first-page":"56","DOI":"10.46582\/jsrm.1702009","volume":"30","author":"A Terunuma","year":"2021","unstructured":"Terunuma A, Yoshioka Y, Sekine T, Takane T, Shimizu Y, Narita S et al (2021) Extracellular vesicles from mesenchymal stem cells of dental pulp and adipose tissue display distinct transcriptomic characteristics suggestive of potential therapeutic targets. J Stem Cells Regen Med 30:56\u201360. https:\/\/doi.org\/10.46582\/jsrm.1702009","journal-title":"J Stem Cells Regen Med"},{"key":"11270_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12051090","volume":"12","author":"T-H Huang","year":"2024","unstructured":"Huang T-H, Chen J-Y, Suo W-H, Shao W-R, Huang C-Y, Li M-T et al (2024) Unlocking the future of periodontal regeneration: an interdisciplinary approach to tissue engineering and advanced therapeutics. Biomedicines 12:1090. https:\/\/doi.org\/10.3390\/biomedicines12051090","journal-title":"Biomedicines"},{"key":"11270_CR64","doi-asserted-by":"publisher","first-page":"szae092","DOI":"10.1093\/stcltm\/szae092","volume":"18","author":"L Jing","year":"2025","unstructured":"Jing L, Wang H-Y, Zhang N, Zhang W-J, Chen Y, Deng D-K et al (2025) Critical roles of extracellular vesicles in periodontal disease and regeneration. Stem Cells Transl Med 18:szae092. https:\/\/doi.org\/10.1093\/stcltm\/szae092","journal-title":"Stem Cells Transl Med"},{"key":"11270_CR65","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/odi.13244","volume":"26","author":"T Hiraki","year":"2020","unstructured":"Hiraki T, Kunimatsu R, Nakajima K, Abe T, Yamada S, Rikitake K, Tanimoto K (2020) Stem cell-derived conditioned medium from human exfoliated deciduous teeth promote bone regeneration. Oral Dis 26:381\u2013390. https:\/\/doi.org\/10.1111\/odi.13244","journal-title":"Oral Dis"},{"key":"11270_CR66","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.joen.2020.06.020","volume":"46","author":"GT-J Huang","year":"2020","unstructured":"Huang GT-J, Liu J, Zhu X, Yu Z, Li D, Chen C-A et al (2020) Pulp\/Dentin regeneration: it should be complicated. J Endod 46:128\u2013134. https:\/\/doi.org\/10.1016\/j.joen.2020.06.020","journal-title":"J Endod"},{"key":"11270_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112573","volume":"237","author":"G Zhang","year":"2022","unstructured":"Zhang G, Yi L, Wang C, Yang P, Zhang J, Wang J et al (2022) Photobiomodulation promotes angiogenesis in wound healing through stimulating the nuclear translocation of VEGFR2 and STAT3. J Photochem Photobiol B 237:112573. https:\/\/doi.org\/10.1016\/j.jphotobiol.2022.112573","journal-title":"J Photochem Photobiol B"},{"key":"11270_CR68","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.55522\/jmpas.V11I3.3775","volume":"11","author":"LM Abdelgawad","year":"2022","unstructured":"Abdelgawad LM (2022) Influence of photo biomodulation using 980 Nm diode laser and exsosomes derived from dental pulp stem cells on pulp regeneration of dogs\u2019 teeth. J Med Pharm Allied Sci 11:4980\u20134985","journal-title":"J Med Pharm Allied Sci"},{"key":"11270_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6684667","author":"MS Moreira","year":"2021","unstructured":"Moreira MS, Sarra G, Carvalho GL, Gon\u00e7alves F, Caballero-Flores HV, Pedroni ACF et al (2021) Physical and biological properties of a Chitosan hydrogel scaffold associated to photobiomodulation therapy for dental pulp regeneration: an In vitroand In vivostudy. BioMed Res Int. https:\/\/doi.org\/10.1155\/2021\/6684667","journal-title":"BioMed Res Int"},{"key":"11270_CR70","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13005-024-00460-y","volume":"20","author":"H Elnawam","year":"2024","unstructured":"Elnawam H, Thabet A, Mobarak A, Khalil NM, Abdallah A, Nouh S et al (2024) Bovine pulp extracellular matrix hydrogel for regenerative endodontic applications: in vitro characterization and in vivo analysis in a necrotic tooth model. Head Face Med 20:61. https:\/\/doi.org\/10.1186\/s13005-024-00460-y","journal-title":"Head Face Med"},{"key":"11270_CR71","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.5395\/rde.2023.48.e20","volume":"48","author":"DA Hammouda","year":"2023","unstructured":"Hammouda DA, Mansour AM, Saeed MA, Zaher AR, Grawish ME (2023) Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review. Restor Dent Endod 48:e20. https:\/\/doi.org\/10.5395\/rde.2023.48.e20","journal-title":"Restor Dent Endod"},{"key":"11270_CR72","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.jdent.2014.07.007","volume":"42","author":"D Li","year":"2014","unstructured":"Li D, Fu L, Zhang Y, Yu Q, Ma F, Wang Z et al (2014) The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro. J Dent 42:1327\u201334. https:\/\/doi.org\/10.1016\/j.jdent.2014.07.007","journal-title":"J Dent"},{"key":"11270_CR73","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.yexcr.2016.11.012","volume":"350","author":"N Herzmann","year":"2017","unstructured":"Herzmann N, Salamon A, Fiedler T, Peters K (2017) Lipopolysaccharide induces proliferation and osteogenic differentiation of adipose-derived mesenchymal stromal cells in vitro via TLR4 activation. Exp Cell Res 350:115\u201322. https:\/\/doi.org\/10.1016\/j.yexcr.2016.11.012","journal-title":"Exp Cell Res"},{"key":"11270_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1397722","author":"T Zheng","year":"2024","unstructured":"Zheng T, Li S, Zhang T, Fu W, Liu S, He Y et al (2024) Exosome-shuttled miR-150\u20135p from LPS-preconditioned mesenchymal stem cells down-regulate PI3K\/Akt\/mTOR pathway via Irs1 to enhance M2 macrophage polarization and confer protection against sepsis. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2024.1397722","journal-title":"Front Immunol"},{"key":"11270_CR75","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1111\/jcmm.14635","volume":"23","author":"R Xu","year":"2019","unstructured":"Xu R, Zhang F, Chai R, Zhou W, Hu M, Liu B et al (2019) Exosomes derived from pro-inflammatory bone marrow\u2010derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization. J Cell Mol Med 23:7617\u201331. https:\/\/doi.org\/10.1111\/jcmm.14635","journal-title":"J Cell Mol Med"},{"key":"11270_CR76","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1186\/s12903-024-04835-0","volume":"24","author":"R El-Qashty","year":"2024","unstructured":"El-Qashty R, Youssef J, Hany E (2024) The role of erythropoietin-loaded hydrogel versus adipose derived stem cell secretome in the regeneration of tongue defects. BMC Oral Health 24:1109. https:\/\/doi.org\/10.1186\/s12903-024-04835-0","journal-title":"BMC Oral Health"},{"key":"11270_CR77","doi-asserted-by":"publisher","first-page":"100602","DOI":"10.1016\/j.esmoop.2022.100602","volume":"7","author":"C van Herpen","year":"2022","unstructured":"van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A et al (2022) Salivary gland cancer: ESMO\u2013European reference network on rare adult solid cancers (EURACAN) clinical practice guideline for diagnosis, treatment and follow-up. ESMO Open 7:100602. https:\/\/doi.org\/10.1016\/j.esmoop.2022.100602","journal-title":"ESMO Open"},{"key":"11270_CR78","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00520-024-08691-0","volume":"32","author":"C Hong","year":"2024","unstructured":"Hong C, Epstein JB, Jensen SB, Gueiros LA, van Leeuwen SJM, Kandwal A et al (2024) MASCC\/ISOO clinical practice statement: clinical assessment of salivary gland hypofunction and xerostomia in cancer patients. Support Care Cancer 32:551. https:\/\/doi.org\/10.1007\/s00520-024-08691-0","journal-title":"Support Care Cancer"},{"key":"11270_CR79","doi-asserted-by":"publisher","first-page":"e1547","DOI":"10.4317\/jced.62242","volume":"16","author":"MS Moreira","year":"2024","unstructured":"Moreira MS, Mota ME, Ariga SK, Jaguar GC, Marques MM (2024) Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: a scoping review. J Clin Exp Dent 16:e1547\u2013e1554. https:\/\/doi.org\/10.4317\/jced.62242","journal-title":"J Clin Exp Dent"},{"key":"11270_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061632","volume":"8","author":"SD Tran","year":"2013","unstructured":"Tran SD, Liu Y, Xia D, Maria OM, Khalili S, Wang RW-J et al (2013) Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation. PLoS ONE 8:e61632. https:\/\/doi.org\/10.1371\/journal.pone.0061632","journal-title":"PLoS ONE"},{"key":"11270_CR81","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","volume":"180","author":"A Ho-Shui-Ling","year":"2018","unstructured":"Ho-Shui-Ling A, Bolander J, Rustom LE, Johnson AW, Luyten FP, Picart C (2018) Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials 180:143\u2013162. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.07.017","journal-title":"Biomaterials"},{"key":"11270_CR82","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1016\/j.matt.2022.06.003","volume":"5","author":"SS Lee","year":"2022","unstructured":"Lee SS, Du X, Kim I, Ferguson SJ (2022) Scaffolds for bone-tissue engineering. Matter 5:2722\u20132759. https:\/\/doi.org\/10.1016\/j.matt.2022.06.003","journal-title":"Matter"},{"key":"11270_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15060145","volume":"15","author":"J Quek","year":"2024","unstructured":"Quek J, Vizetto-Duarte C, Teoh SH, Choo Y (2024) Towards stem cell therapy for critical-sized segmental bone defects: current trends and challenges on the path to clinical translation. J Funct Biomater 15:145. https:\/\/doi.org\/10.3390\/jfb15060145","journal-title":"J Funct Biomater"},{"key":"11270_CR84","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jare.2024.01.011","volume":"66","author":"Y Wu","year":"2024","unstructured":"Wu Y, Song P, Wang M, Liu H, Jing Y, Su J (2024) Extracellular derivatives for bone metabolism. J Adv Res 66:329\u2013347. https:\/\/doi.org\/10.1016\/j.jare.2024.01.011","journal-title":"J Adv Res"},{"key":"11270_CR85","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2021.10.029","volume":"185","author":"SG Varadarajan","year":"2022","unstructured":"Varadarajan SG, Hunyara JL, Hamilton NR, Kolodkin AL, Huberman AD (2022) Central nervous system regeneration. Cell 185:77\u201394. https:\/\/doi.org\/10.1016\/j.cell.2021.10.029","journal-title":"Cell"},{"key":"11270_CR86","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1002\/jbm.a.36067","volume":"105","author":"K Nawrotek","year":"2017","unstructured":"Nawrotek K, Marqueste T, Modrzejewska Z, Zarzycki R, Rusak A, Decherchi P (2017) Thermogelling chitosan lactate hydrogel improves functional recovery after a C2 spinal cord hemisection in rat. J Biomed Mater Res A 105:2004\u20132019. https:\/\/doi.org\/10.1002\/jbm.a.36067","journal-title":"J Biomed Mater Res A"},{"key":"11270_CR87","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1016\/j.biomaterials.2009.11.078","volume":"31","author":"L Mo","year":"2010","unstructured":"Mo L, Yang Z, Zhang A, Li X (2010) The repair of the injured adult rat hippocampus with NT-3-chitosan carriers. Biomaterials 31:2184\u20132192. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.11.078","journal-title":"Biomaterials"},{"key":"11270_CR88","doi-asserted-by":"publisher","first-page":"30081","DOI":"10.1021\/acsami.8b08449","volume":"10","author":"K Zhang","year":"2018","unstructured":"Zhang K, Zhao X, Chen X, Wei Y, Du W, Wang Y et al (2018) Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces 10:30081\u201330091. https:\/\/doi.org\/10.1021\/acsami.8b08449","journal-title":"ACS Appl Mater Interfaces"},{"key":"11270_CR89","doi-asserted-by":"crossref","unstructured":"Zhou C, Zhang B, Yang Y, Jiang Q, Li T, Gong J et al (2023) Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Res Ther 14 107.","DOI":"10.1186\/s13287-023-03345-0"},{"key":"11270_CR90","doi-asserted-by":"publisher","unstructured":"Burgess JL, Wyant WA, Abdo Abujamra B, Kirsner RS, Jozic I (2021) Diabetic Wound-Healing science. Med (Kaunas) 57. https:\/\/doi.org\/10.1111\/bjd.13954","DOI":"10.1111\/bjd.13954"},{"key":"11270_CR91","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","volume":"11","author":"EA Makris","year":"2015","unstructured":"Makris EA, Gomoll AH, Malizos KN, Hu JC, Athanasiou KA (2015) Repair and tissue engineering techniques for articular cartilage. Nat Rev Rheumatol 11:21\u201334. https:\/\/doi.org\/10.1038\/nrrheum.2014.157","journal-title":"Nat Rev Rheumatol"},{"key":"11270_CR92","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.bioactmat.2024.04.017","volume":"38","author":"X Lu","year":"2024","unstructured":"Lu X, Dai S, Huang B, Li S, Wang P, Zhao Z et al (2024) Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect. Bioact Mater 38:137\u201353. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.04.017","journal-title":"Bioact Mater"},{"key":"11270_CR93","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.7150\/thno.31017","volume":"9","author":"P Chen","year":"2019","unstructured":"Chen P, Zheng L, Wang Y, Tao M, Xie Z, Xia C, Gu C et al (2019) Desktop-stereolithography 3D printing of a radially oriented extracellular matrix\/mesenchymal stem cell exosome bioink for osteochondral defect regeneration. Theranostics 9:2439\u20132459. https:\/\/doi.org\/10.7150\/thno.31017","journal-title":"Theranostics"},{"key":"11270_CR94","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.jconrel.2023.07.032","volume":"360","author":"J Cui","year":"2023","unstructured":"Cui J, Zhang Y-J, Li X, Luo J-J, Zhao L-L, Xie X-Y et al (2023) Decellularized tendon scaffolds loaded with collagen targeted extracellular vesicles from tendon-derived stem cells facilitate tendon regeneration. J Control Release 360:842\u201357. https:\/\/doi.org\/10.1016\/j.jconrel.2023.07.032","journal-title":"J Control Release"},{"key":"11270_CR95","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.actbio.2023.10.004","volume":"172","author":"T Zhang","year":"2023","unstructured":"Zhang T, Wu Y, Li X, Zhang A, Liu H, Shi M et al (2023) Small extracellular vesicles derived from tendon stem cells promote the healing of injured Achilles tendons by regulating miR-145-3p. Acta Biomater 172:280\u201396. https:\/\/doi.org\/10.1016\/j.actbio.2023.10.004","journal-title":"Acta Biomater"},{"key":"11270_CR96","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1111\/cas.15801","volume":"114","author":"Z Ye","year":"2023","unstructured":"Ye Z, Yu Z, Chen G, Jia J (2023) Extracellular vesicles in tumor angiogenesis and resistance to anti-angiogenic therapy. Cancer Sci 114:2739\u20132749. https:\/\/doi.org\/10.1111\/cas.15801","journal-title":"Cancer Sci"},{"key":"11270_CR97","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s13402-017-0335-7","volume":"40","author":"K Pakravan","year":"2017","unstructured":"Pakravan K, Babashah S, Sadeghizadeh M, Mowla SJ, Mossahebi-Mohammadi M, Ataei F et al (2017) MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR\/HIF-1\u03b1\/VEGF signaling axis in breast cancer cells. Cell Oncol 40:457\u2013470. https:\/\/doi.org\/10.1007\/s13402-017-0335-7","journal-title":"Cell Oncol"},{"key":"11270_CR98","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He C, Zheng S, Luo Y, Wang B (2018) Exosome theranostics: biology and translational medicine. Theranostics 8:237\u2013255. https:\/\/doi.org\/10.7150\/thno.21945","journal-title":"Theranostics"},{"key":"11270_CR99","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.actbio.2020.09.052","volume":"18","author":"WB Swanson","year":"2020","unstructured":"Swanson WB, Zhang Z, Xiu K, Gong T, Eberle M, Wang Z et al (2020) Scaffolds with controlled release of pro-mineralization exosomes to promote craniofacial bone healing without cell transplantation. Acta Biomater 18:215\u2013232. https:\/\/doi.org\/10.1016\/j.actbio.2020.09.052","journal-title":"Acta Biomater"},{"key":"11270_CR100","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12473","author":"X Duan","year":"2024","unstructured":"Duan X, Zhang R, Feng H, Zhou H, Luo Y, Xiong W et al (2024) A new subtype of artificial cell-derived vesicles from dental pulp stem cells with the bioequivalence and higher acquisition efficiency compared to extracellular vesicles. J Extracell Vesicles. https:\/\/doi.org\/10.1002\/jev2.12473","journal-title":"J Extracell Vesicles"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11270-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11270-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11270-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:22:18Z","timestamp":1764134538000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11270-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11270"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11270-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"116"}}