{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:29Z","timestamp":1786981469477,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["99-1-4-18188"],"award-info":[{"award-number":["99-1-4-18188"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11285-6","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:25:03Z","timestamp":1763987103000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of nitric oxide and connexin 43 in the cardioprotective effects of apigenin against doxorubicin-induced cardiotoxicity in male rats"],"prefix":"10.1007","volume":"53","author":[{"given":"Atlasi","family":"Safaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Fallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"issue":"4","key":"11285_CR1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s12012-022-09721-1","volume":"22","author":"M Sheibani","year":"2022","unstructured":"Sheibani M et al (2022) Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches. Cardiovasc Toxicol 22(4):292\u2013310","journal-title":"Cardiovasc Toxicol"},{"issue":"1","key":"11285_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","volume":"10","author":"AN Linders","year":"2024","unstructured":"Linders AN et al (2024) A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging. NPJ Aging 10(1):9","journal-title":"NPJ Aging"},{"issue":"9","key":"11285_CR3","doi-asserted-by":"publisher","first-page":"100994","DOI":"10.1016\/j.cpcardiol.2021.100994","volume":"47","author":"A Avagimyan","year":"2022","unstructured":"Avagimyan A et al (2022) AC-Mode of chemotherapy as a trigger of cardiac syndrome X: A case study. Curr Probl Cardiol 47(9):100994","journal-title":"Curr Probl Cardiol"},{"issue":"3","key":"11285_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/HCO.0000000000000617","volume":"34","author":"BW Hardaway","year":"2019","unstructured":"Hardaway BW (2019) Adriamycin-associated cardiomyopathy: where are we now? Updates in pathophysiology, dose recommendations, prognosis, and outcomes. Curr Opin Cardiol 34(3):289\u2013295","journal-title":"Curr Opin Cardiol"},{"issue":"4","key":"11285_CR5","first-page":"20","volume":"46","author":"R Hayward","year":"2007","unstructured":"Hayward R, Hydock DS (2007) Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci 46(4):20\u201332","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"11285_CR6","doi-asserted-by":"publisher","first-page":"v277","DOI":"10.1093\/annonc\/mdq200","volume":"21","author":"D Bovelli","year":"2010","unstructured":"Bovelli D, Plataniotis G, Roila F (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines. Ann Oncol 21:v277\u2013v282","journal-title":"Ann Oncol"},{"issue":"1","key":"11285_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1289\/ehp.0110927","volume":"109","author":"KM Pollard","year":"2001","unstructured":"Pollard KM et al (2001) Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone Bxsb mice. Environ Health Perspect 109(1):27\u201333","journal-title":"Environ Health Perspect"},{"issue":"2","key":"11285_CR8","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1016\/j.bbrc.2017.12.051","volume":"495","author":"P Mandal","year":"2018","unstructured":"Mandal P (2018) Insight of nitric oxide signaling: a potential biomarker with multifaceted complex mechanism in colorectal carcinogenesis. Biochem Biophys Res Commun 495(2):1766\u20131768","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"11285_CR9","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","volume":"15","author":"C Farah","year":"2018","unstructured":"Farah C, Michel LY, Balligand J-L (2018) Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol 15(5):292\u2013316","journal-title":"Nat Rev Cardiol"},{"key":"11285_CR10","doi-asserted-by":"crossref","unstructured":"Pierini D, Bryan NS (2015) Nitric oxide availability as a marker of oxidative stress. Adv Protocols Oxidative Stress 1208:63\u201371","DOI":"10.1007\/978-1-4939-1441-8_5"},{"issue":"2","key":"11285_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.HYP.38.2.274","volume":"38","author":"S Taddei","year":"2001","unstructured":"Taddei S et al (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38(2):274\u2013279","journal-title":"Hypertension"},{"key":"11285_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.taap.2016.01.006","volume":"293","author":"M Pecoraro","year":"2016","unstructured":"Pecoraro M et al (2016) Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity. Toxicol Appl Pharmcol 293:44\u201352","journal-title":"Toxicol Appl Pharmcol"},{"issue":"5","key":"11285_CR13","doi-asserted-by":"publisher","first-page":"H1466","DOI":"10.1152\/ajpheart.00795.2008","volume":"296","author":"P Mukhopadhyay","year":"2009","unstructured":"Mukhopadhyay P et al (2009) Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol 296(5):H1466\u2013H1483","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"11285_CR14","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1111\/jcmm.13231","volume":"21","author":"Y Octavia","year":"2017","unstructured":"Octavia Y et al (2017) Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase. J Cell Mol Med 21(12):3277\u20133287","journal-title":"J Cell Mol Med"},{"issue":"1","key":"11285_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.bbamem.2017.05.016","volume":"1860","author":"EC Beyer","year":"2018","unstructured":"Beyer EC, Berthoud VM (2018) Gap junction gene and protein families: connexins, innexins, and pannexins. Biochim Et Biophys Acta (BBA)-Biomembranes 1860(1):5\u20138","journal-title":"Biochim Et Biophys Acta (BBA)-Biomembranes"},{"key":"11285_CR16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0008-6363(01)00324-8","volume":"51","author":"A Van Veen","year":"2001","unstructured":"Van Veen A, van Rijen HV, Opthof T (2001) Cardiac gap junction channels: modulation of expression and channel properties. Cardiovasc Res 51:217\u2013229","journal-title":"Cardiovasc Res"},{"issue":"3","key":"11285_CR17","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1042\/BST20150059","volume":"43","author":"LW Stroemlund","year":"2015","unstructured":"Stroemlund LW et al (2015) Gap junctions\u2013guards of excitability. Biochem Soc Trans 43(3):508\u2013512","journal-title":"Biochem Soc Trans"},{"key":"11285_CR18","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1159\/000092567","volume":"42","author":"HV van Rijen","year":"2006","unstructured":"van Rijen HV et al (2006) Connexins and cardiac arrhythmias. Cardiovasc Gap Junctions 42:150\u2013160","journal-title":"Cardiovasc Gap Junctions"},{"issue":"3","key":"11285_CR19","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/ijms19030757","volume":"19","author":"M Pecoraro","year":"2018","unstructured":"Pecoraro M et al (2018) Diazoxide improves mitochondrial connexin 43 expression in a mouse model of doxorubicin-induced cardiotoxicity. Int J Mol Sci 19(3):757","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11285_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1748-1716.2008.01858.x","volume":"194","author":"P Jackson","year":"2008","unstructured":"Jackson P, Feng Q, Jones D (2008) Nitric oxide depresses connexin 43 after myocardial infarction in mice. Acta Physiol 194(1):23\u201333","journal-title":"Acta Physiol"},{"issue":"3","key":"11285_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/17425255.2017.1251903","volume":"13","author":"D Tang","year":"2017","unstructured":"Tang D et al (2017) Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. Expert Opin Drug Metab Toxicol 13(3):323\u2013330","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"7","key":"11285_CR22","first-page":"312","volume":"21","author":"M Sheibani","year":"2018","unstructured":"Sheibani M, Nayernouri T, Dehpour AR (2018) Herbal medicines and other traditional remedies in Iran - a tragedy unfolds. Arch Iran Med 21(7):312\u2013314","journal-title":"Arch Iran Med"},{"key":"11285_CR23","doi-asserted-by":"publisher","first-page":"104585","DOI":"10.1016\/j.pestbp.2020.104585","volume":"167","author":"A Jahedsani","year":"2020","unstructured":"Jahedsani A et al (2020) Apigenin attenuates aluminum phosphide-induced cytotoxicity via reducing mitochondrial\/Lysosomal damages and oxidative stress in rat cardiomyocytes. Pestic Biochem Physiol 167:104585","journal-title":"Pestic Biochem Physiol"},{"issue":"3","key":"11285_CR24","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s12012-014-9290-y","volume":"15","author":"J Hu","year":"2015","unstructured":"Hu J et al (2015) Protective effect of apigenin on ischemia\/reperfusion injury of the isolated rat heart. Cardiovasc Toxicol 15(3):241\u2013249","journal-title":"Cardiovasc Toxicol"},{"issue":"11","key":"11285_CR25","doi-asserted-by":"publisher","first-page":"e22213","DOI":"10.1002\/jbt.22213","volume":"32","author":"R Thangaiyan","year":"2018","unstructured":"Thangaiyan R et al (2018) Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. J Biochem Mol Toxicol 32(11):e22213","journal-title":"J Biochem Mol Toxicol"},{"key":"11285_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2590676","author":"W Yu","year":"2017","unstructured":"Yu W et al (2017) Apigenin attenuates adriamycin-induced cardiomyocyte apoptosis via the PI3K\/AKT\/mTOR pathway. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2017\/2590676","journal-title":"Evid Based Complement Alternat Med"},{"key":"11285_CR27","doi-asserted-by":"publisher","first-page":"116623","DOI":"10.1016\/j.lfs.2019.116623","volume":"232","author":"MFR Zare","year":"2019","unstructured":"Zare MFR et al (2019) Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Life Sci 232:116623","journal-title":"Life Sci"},{"key":"11285_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14024","author":"Z Sharifiaghdam","year":"2023","unstructured":"Sharifiaghdam Z et al (2023) Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity in male rats via reducing apoptosis. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e14024","journal-title":"Heliyon"},{"key":"11285_CR29","doi-asserted-by":"crossref","unstructured":"Cogliati B et al (2016) Immunohisto-and cytochemistry analysis of connexins. Gap Junction Protocols 1437:55\u201370","DOI":"10.1007\/978-1-4939-3664-9_4"},{"key":"11285_CR30","doi-asserted-by":"publisher","first-page":"104329","DOI":"10.1016\/j.yexmp.2019.104329","volume":"112","author":"S Nezamoleslami","year":"2020","unstructured":"Nezamoleslami S et al (2020) Glatiramer acetate attenuates renal ischemia reperfusion injury in rat model. Exp Mol Pathol 112:104329","journal-title":"Exp Mol Pathol"},{"key":"11285_CR31","doi-asserted-by":"publisher","first-page":"131331","DOI":"10.1016\/j.ijcard.2023.131331","volume":"391","author":"A Avagimyan","year":"2023","unstructured":"Avagimyan A et al (2023) Possibilities of dapagliflozin-induced cardioprotection on doxorubicin\u2009+\u2009cyclophosphamide mode of chemotherapy-induced cardiomyopathy. Int J Cardiol 391:131331","journal-title":"Int J Cardiol"},{"key":"11285_CR32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.lfs.2018.06.022","volume":"207","author":"M Khalilzadeh","year":"2018","unstructured":"Khalilzadeh M et al (2018) Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats. Life Sci 207:436\u2013441","journal-title":"Life Sci"},{"issue":"1","key":"11285_CR33","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/med.21280","volume":"34","author":"FS Carvalho","year":"2014","unstructured":"Carvalho FS et al (2014) Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev 34(1):106\u2013135","journal-title":"Med Res Rev"},{"issue":"1","key":"11285_CR34","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s13346-024-01648-0","volume":"15","author":"A Bisht","year":"2025","unstructured":"Bisht A et al (2025) A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer. Drug Deliv Transl Res 15(1):102\u2013133","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"11285_CR35","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"MA Cinelli","year":"2020","unstructured":"Cinelli MA et al (2020) Inducible nitric oxide synthase: Regulation, structure, and Inhibition. Med Res Rev 40(1):158\u2013189","journal-title":"Med Res Rev"},{"key":"11285_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","volume":"307","author":"M Songbo","year":"2019","unstructured":"Songbo M et al (2019) Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicol Lett 307:41\u201348","journal-title":"Toxicol Lett"},{"issue":"10","key":"11285_CR37","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.2174\/092986610792231573","volume":"17","author":"Y Hu","year":"2010","unstructured":"Hu Y et al (2010) Anti-oxidative stress and beyond: multiple functions of the protein glutathionylation. Protein Pept Lett 17(10):1234\u20131244","journal-title":"Protein Pept Lett"},{"issue":"1","key":"11285_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0003-2697(83)90131-8","volume":"131","author":"CO Beauchamp","year":"1983","unstructured":"Beauchamp CO et al (1983) A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and \u03b12-macroglobulin. Anal Biochem 131(1):25\u201333","journal-title":"Anal Biochem"},{"issue":"8","key":"11285_CR39","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.2460\/ajvr.67.8.1319","volume":"67","author":"RCA de Souza","year":"2006","unstructured":"de Souza RCA, Camacho AA (2006) Neurohormonal, hemodynamic, and electrocardiographic evaluations of healthy dogs receiving long-term administration of doxorubicin. Am J Vet Res 67(8):1319\u20131325","journal-title":"Am J Vet Res"},{"issue":"1","key":"11285_CR40","first-page":"85","volume":"20","author":"K Rakhshan","year":"2018","unstructured":"Rakhshan K et al (2018) Apigenin improves myocardial function and attenuates cardiotoxicity induced by doxorubicin in male rats. Yafteh 20(1):85\u201398","journal-title":"Yafteh"},{"issue":"10","key":"11285_CR41","first-page":"161","volume":"111","author":"A Schlitt","year":"2014","unstructured":"Schlitt A et al (2014) Kardiotoxizit\u00e4t onkologischer therapien. Deutsches Arzteblatt Int 111(10):161\u2013168","journal-title":"Deutsches Arzteblatt Int"},{"key":"11285_CR42","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/BF02912874","volume":"22","author":"P Nigam","year":"2007","unstructured":"Nigam P (2007) Biochemical markers of myocardial injury. Indian J Clin Biochem 22:10\u201317","journal-title":"Indian J Clin Biochem"},{"key":"11285_CR43","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","volume":"146","author":"S Hinderer","year":"2019","unstructured":"Hinderer S, Schenke-Layland K (2019) Cardiac fibrosis\u2013a short review of causes and therapeutic strategies. Adv Drug Deliv Rev 146:77\u201382","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"11285_CR44","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1172\/JCI72931","volume":"124","author":"Y Ichikawa","year":"2014","unstructured":"Ichikawa Y et al (2014) Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Investig 124(2):617\u2013630","journal-title":"J Clin Investig"},{"issue":"10","key":"11285_CR45","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.hlc.2018.08.003","volume":"28","author":"SP Levick","year":"2019","unstructured":"Levick SP et al (2019) Doxorubicin-induced myocardial fibrosis involves the neurokinin-1 receptor and direct effects on cardiac fibroblasts. Heart Lung Circulation 28(10):1598\u20131605","journal-title":"Heart Lung Circulation"},{"issue":"2","key":"11285_CR46","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/cvr\/cvt181","volume":"100","author":"A Kazakov","year":"2013","unstructured":"Kazakov A et al (2013) Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis. Cardiovascular Res 100(2):211\u2013221","journal-title":"Cardiovascular Res"},{"key":"11285_CR47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10741-012-9365-4","volume":"19","author":"AM Segura","year":"2014","unstructured":"Segura AM, Frazier O, Buja LM (2014) Fibrosis and heart failure. Heart Fail Rev 19:173\u2013185","journal-title":"Heart Fail Rev"},{"issue":"10","key":"11285_CR48","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.3390\/ijms18102121","volume":"18","author":"M Pecoraro","year":"2017","unstructured":"Pecoraro M et al (2017) Cardiotoxic effects of short-term doxorubicin administration: involvement of connexin 43 in calcium impairment. Int J Mol Sci 18(10):2121","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11285_CR49","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1681\/ASN.2004060453","volume":"16","author":"J Yao","year":"2005","unstructured":"Yao J et al (2005) Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells. J Am Soc Nephrol 16(1):58\u201367","journal-title":"J Am Soc Nephrol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11285-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11285-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11285-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:16:57Z","timestamp":1764181017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11285-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11285"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11285-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"18 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential conflict of interest was reported by the author(s).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\u00a0"}}],"article-number":"113"}}