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The study adhered to the ethical principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants who could be contacted. For a subset of cases, de-identified samples were obtained from the institution\u2019s biological sample repository, collected previously under protocols authorized by the Ethics Committee, which also approved their secondary use for the present study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"151"}}