{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:14:30Z","timestamp":1794014070349,"version":"4.8.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11361-x","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:27:05Z","timestamp":1766143625000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epitranscriptomic regulation via m6A RNA modification in PCOS pathophysiology"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1355-005X","authenticated-orcid":false,"given":"Snehal","family":"Bhingardeve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9452-5020","authenticated-orcid":false,"given":"Purva","family":"Kadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-4428","authenticated-orcid":false,"given":"Srabani","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"11361_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2024.2405098","author":"Y-X Jin","year":"2024","unstructured":"Jin Y-X, Hu H-Q, Zhang J-C et al (2024) Research status of polycystic ovary syndrome treatment: a mini review and a bibliometric analysis from 2010 to 2023. Gynecol Endocrinol. https:\/\/doi.org\/10.1080\/09513590.2024.2405098","journal-title":"Gynecol Endocrinol"},{"key":"11361_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8101606","volume":"8","author":"D Hiam","year":"2019","unstructured":"Hiam D, Moreno-Asso A, Teede HJ et al (2019) The genetics of polycystic ovary syndrome: an overview of candidate gene systematic reviews and genome-wide association studies. J Clin Med 8:1606. https:\/\/doi.org\/10.3390\/jcm8101606","journal-title":"J Clin Med"},{"key":"11361_CR3","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s12265-021-10108-w","volume":"14","author":"Y Chen","year":"2021","unstructured":"Chen Y, Ouyang X, Yu X et al (2021) N6-adenosine methylation (m6A) RNA modification: an emerging role in cardiovascular diseases. J Cardiovasc Transl Res 14:857\u2013872. https:\/\/doi.org\/10.1007\/s12265-021-10108-w","journal-title":"J Cardiovasc Transl Res"},{"key":"11361_CR4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2147\/TACG.S200341","volume":"12","author":"MJ Khan","year":"2019","unstructured":"Khan MJ, Ullah A, Basit S (2019) Xxaaap>genetic basis of polycystic ovary syndrome (PCOS): current perspectives<\/p>. Appl Clin Genet 12:249\u2013260. https:\/\/doi.org\/10.2147\/TACG.S200341","journal-title":"Appl Clin Genet"},{"key":"11361_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.reprotox.2022.04.010","volume":"111","author":"Y-N Liu","year":"2022","unstructured":"Liu Y-N, Qin Y, Wu B et al (2022) DNA methylation in polycystic ovary syndrome: emerging evidence and challenges. Reprod Toxicol 111:11\u201319. https:\/\/doi.org\/10.1016\/j.reprotox.2022.04.010","journal-title":"Reprod Toxicol"},{"key":"11361_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1024320","author":"H Wei","year":"2022","unstructured":"Wei H, Huo P, Liu S et al (2022) Posttranslational modifications in pathogenesis of PCOS. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2022.1024320","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11361_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2025.104838","author":"S Bhingardeve","year":"2025","unstructured":"Bhingardeve S, Sagvekar P, Mukherjee S (2025) Altered DNA methylation and miRNA expression: epi-marks for elucidating the pathophysiology of PCOS. Reprod Biomed Online. https:\/\/doi.org\/10.1016\/j.rbmo.2025.104838","journal-title":"Reprod Biomed Online"},{"key":"11361_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2024.148130","volume":"898","author":"Y-L Li","year":"2024","unstructured":"Li Y-L, Zhang Y, Chen N, Yan Y-X (2024) The role of m6A modification in type 2 diabetes: a systematic review and integrative analysis. Gene 898:148130. https:\/\/doi.org\/10.1016\/j.gene.2024.148130","journal-title":"Gene"},{"key":"11361_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.908976","author":"L Li","year":"2022","unstructured":"Li L, Xu N, Liu J et al (2022) m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2022.908976","journal-title":"Front Genet"},{"key":"11361_CR10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1186\/s12935-021-02371-3","volume":"21","author":"L-L Chang","year":"2021","unstructured":"Chang L-L, Xu X-Q, Liu X-L et al (2021) Emerging role of m6A methylation modification in ovarian cancer. Cancer Cell Int 21:663. https:\/\/doi.org\/10.1186\/s12935-021-02371-3","journal-title":"Cancer Cell Int"},{"key":"11361_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1537861","author":"IM Artika","year":"2025","unstructured":"Artika IM, Arianti R, Dem\u00e9ny M\u00c1, Krist\u00f3f E (2025) RNA modifications and their role in gene expression. Front Mol Biosci. https:\/\/doi.org\/10.3389\/fmolb.2025.1537861","journal-title":"Front Mol Biosci"},{"key":"11361_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.884295","author":"X Sun","year":"2022","unstructured":"Sun X, Lu J, Li H, Huang B (2022) The role of m6A on female reproduction and fertility: from gonad development to ovarian aging. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2022.884295","journal-title":"Front Cell Dev Biol"},{"key":"11361_CR13","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.7150\/ijbs.69771","volume":"18","author":"J Chen","year":"2022","unstructured":"Chen J, Fang Y, Xu Y, Sun H (2022) Role of m6A modification in female infertility and reproductive system diseases. Int J Biol Sci 18:3592\u20133604. https:\/\/doi.org\/10.7150\/ijbs.69771","journal-title":"Int J Biol Sci"},{"key":"11361_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13048-023-01147-9","volume":"16","author":"S Zhou","year":"2023","unstructured":"Zhou S, Hua R, Quan S (2023) N6-methyladenosine regulator-mediated methylation modification patterns and immune infiltration characterization in polycystic ovary syndrome (PCOS). J Ovarian Res 16:73. https:\/\/doi.org\/10.1186\/s13048-023-01147-9","journal-title":"J Ovarian Res"},{"key":"11361_CR15","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2276167","author":"Y-X Jing","year":"2023","unstructured":"Jing Y-X, Li H-X, Yue F et al (2023) N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway. Gynecol Endocrinol. https:\/\/doi.org\/10.1080\/09513590.2023.2276167","journal-title":"Gynecol Endocrinol"},{"key":"11361_CR16","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","volume":"71","author":"R Desrosiers","year":"1974","unstructured":"Desrosiers R, Friderici K, Rottman F (1974) Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A 71:3971\u20133975. https:\/\/doi.org\/10.1073\/pnas.71.10.3971","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11361_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0092-8674(74)90153-6","volume":"1","author":"RP Perry","year":"1974","unstructured":"Perry RP, Kelley DE (1974) Existence of methylated messenger RNA in mouse L cells. Cell 1:37\u201342. https:\/\/doi.org\/10.1016\/0092-8674(74)90153-6","journal-title":"Cell"},{"key":"11361_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch-Moshkovitz S, Schwartz S et al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201\u2013206. https:\/\/doi.org\/10.1038\/nature11112","journal-title":"Nature"},{"key":"11361_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","volume":"11","author":"Y Niu","year":"2013","unstructured":"Niu Y, Zhao X, Wu Y-S et al (2013) N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics 11:8\u201317. https:\/\/doi.org\/10.1016\/j.gpb.2012.12.002","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"11361_CR20","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105977","author":"PC He","year":"2021","unstructured":"He PC, He C (2021) M 6 A RNA methylation: from mechanisms to therapeutic potential. EMBO J. https:\/\/doi.org\/10.15252\/embj.2020105977","journal-title":"EMBO J"},{"key":"11361_CR21","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200091","author":"W Ru","year":"2020","unstructured":"Ru W, Zhang X, Yue B et al (2020) Insight into m 6 A methylation from occurrence to functions. Open Biol. https:\/\/doi.org\/10.1098\/rsob.200091","journal-title":"Open Biol"},{"key":"11361_CR22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.87283","author":"C Yan","year":"2023","unstructured":"Yan C, Xiong J, Zhou Z et al (2023) A cleaved METTL3 potentiates the METTL3\u2013WTAP interaction and breast cancer progression. Elife. https:\/\/doi.org\/10.7554\/eLife.87283","journal-title":"Elife"},{"key":"11361_CR23","doi-asserted-by":"crossref","unstructured":"Zheng G, Dahl JA, Niu Y, et al (2013) \u00a9 2013 Landes Bioscience PoiNt-of-View PoiNt-of-View Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases.","DOI":"10.4161\/rna.24711"},{"key":"11361_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2822","author":"Y Fu","year":"2013","unstructured":"Fu Y, Jia G, Pang X et al (2013) FTO-mediated formation of N6-hydroxymethyladenosine and N 6-formyladenosine in mammalian RNA. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms2822","journal-title":"Nat Commun"},{"key":"11361_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.559138","author":"N Lan","year":"2020","unstructured":"Lan N, Lu Y, Zhang Y et al (2020) FTO \u2013 a common genetic basis for obesity and cancer. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2020.559138","journal-title":"Front Genet"},{"key":"11361_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang X, Liu B, Nie Z et al (2021) The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther 6:74. https:\/\/doi.org\/10.1038\/s41392-020-00450-x","journal-title":"Signal Transduct Target Ther"},{"key":"11361_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","volume":"22","author":"S Wang","year":"2022","unstructured":"Wang S, Lv W, Li T et al (2022) Dynamic regulation and functions of mRNA m6A modification. Cancer Cell Int 22:48. https:\/\/doi.org\/10.1186\/s12935-022-02452-x","journal-title":"Cancer Cell Int"},{"key":"11361_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1460","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Huo F, Zhang J et al (2023) Crosstalk between m6A modification and alternative splicing during cancer progression. Clin Transl Med. https:\/\/doi.org\/10.1002\/ctm2.1460","journal-title":"Clin Transl Med"},{"key":"11361_CR29","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s12276-022-00897-8","volume":"54","author":"J Hong","year":"2022","unstructured":"Hong J, Xu K, Lee JH (2022) Biological roles of the RNA m6A modification and its implications in cancer. Exp Mol Med 54:1822\u20131832. https:\/\/doi.org\/10.1038\/s12276-022-00897-8","journal-title":"Exp Mol Med"},{"key":"11361_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.molcel.2019.07.005","volume":"76","author":"KI Zhou","year":"2019","unstructured":"Zhou KI, Shi H, Lyu R et al (2019) Regulation of co-transcriptional pre-mRNA splicing by m6A through the low-complexity protein hnRNPG. Mol Cell 76:70\u201381. https:\/\/doi.org\/10.1016\/j.molcel.2019.07.005","journal-title":"Mol Cell"},{"key":"11361_CR31","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","volume":"61","author":"W Xiao","year":"2016","unstructured":"Xiao W, Adhikari S, Dahal U et al (2016) Nuclear m 6 A reader YTHDC1 regulates mRNA splicing. Mol Cell 61:507\u2013519. https:\/\/doi.org\/10.1016\/j.molcel.2016.01.012","journal-title":"Mol Cell"},{"key":"11361_CR32","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer KD, Saletore Y, Zumbo P et al (2012) Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2032 UTRs and near stop codons. Cell 149:1635\u20131646. https:\/\/doi.org\/10.1016\/j.cell.2012.05.003","journal-title":"Cell"},{"key":"11361_CR33","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1016\/j.molcel.2024.10.033","volume":"84","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, \u0106orovi\u0107 M, Hoch-Kraft P et al (2024) m6A sites in the coding region trigger translation-dependent mRNA decay. Mol Cell 84:4576\u20134593. https:\/\/doi.org\/10.1016\/j.molcel.2024.10.033","journal-title":"Mol Cell"},{"key":"11361_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS23084110","volume":"23","author":"D Armanini","year":"2022","unstructured":"Armanini D, Boscaro M, Bordin L, Sabbadin C (2022) Controversies in the pathogenesis, diagnosis and treatment of PCOS: focus on insulin resistance, inflammation, and hyperandrogenism. Int J Mol Sci 23:4110. https:\/\/doi.org\/10.3390\/IJMS23084110","journal-title":"Int J Mol Sci"},{"key":"11361_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113327","volume":"143","author":"L Weng","year":"2024","unstructured":"Weng L, Zhu Q, Xiang Y et al (2024) METTL3-mediated m6A modification of CD36: implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome. Int Immunopharmacol 143:113327. https:\/\/doi.org\/10.1016\/j.intimp.2024.113327","journal-title":"Int Immunopharmacol"},{"key":"11361_CR36","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/S43032-023-01348-Z","volume":"31","author":"B Wang","year":"2024","unstructured":"Wang B, Shi M, Yu C et al (2024) NLRP3 inflammasome-dependent pathway is involved in the pathogenesis of polycystic ovary syndrome. Reprod Sci 31:1017\u20131027. https:\/\/doi.org\/10.1007\/S43032-023-01348-Z","journal-title":"Reprod Sci"},{"key":"11361_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.23592","author":"S Chamanara","year":"2024","unstructured":"Chamanara S, Hozouri V, Irandoost E (2024) Inhibition of NLRP3 inflammasome-a potential mechanistic therapeutic for treatment of polycystic ovary syndrome? J Biochem Mol Toxicol. https:\/\/doi.org\/10.1002\/JBT.23592","journal-title":"J Biochem Mol Toxicol"},{"key":"11361_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01487-9","volume":"15","author":"K Liu","year":"2023","unstructured":"Liu K, He X, Huang J et al (2023) Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome. Clin Epigenetics 15:86. https:\/\/doi.org\/10.1186\/s13148-023-01487-9","journal-title":"Clin Epigenetics"},{"key":"11361_CR39","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s43032-021-00664-6","volume":"29","author":"L Zhou","year":"2022","unstructured":"Zhou L, Han X, Li W et al (2022) N6-methyladenosine demethylase FTO induces the dysfunctions of ovarian granulosa cells by upregulating Flotillin 2. Reprod Sci 29:1305\u20131315. https:\/\/doi.org\/10.1007\/s43032-021-00664-6","journal-title":"Reprod Sci"},{"key":"11361_CR40","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.18632\/AGING.202421","volume":"13","author":"M Tan","year":"2021","unstructured":"Tan M, Cheng Y, Zhong X et al (2021) LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway. Aging 13:4617\u20134633. https:\/\/doi.org\/10.18632\/AGING.202421","journal-title":"Aging"},{"key":"11361_CR41","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2181637","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhou H, Ding C (2023) The ameliorative effect of CangFu Daotan Decoction on polycystic ovary syndrome of rodent model is associated with m6A methylation and Wnt\/\u03b2-catenin pathway. Gynecol Endocrinol. https:\/\/doi.org\/10.1080\/09513590.2023.2181637","journal-title":"Gynecol Endocrinol"},{"key":"11361_CR42","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13048-023-01246-7","volume":"16","author":"L Zou","year":"2023","unstructured":"Zou L, Li W, Xu D et al (2023) Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome. J Ovarian Res 16:157. https:\/\/doi.org\/10.1186\/s13048-023-01246-7","journal-title":"J Ovarian Res"},{"key":"11361_CR43","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s10735-024-10257-7","volume":"55","author":"C Shen","year":"2024","unstructured":"Shen C, Jiang Y, Lin J et al (2024) METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4. J Mol Histol 55:1163\u20131175. https:\/\/doi.org\/10.1007\/s10735-024-10257-7","journal-title":"J Mol Histol"},{"key":"11361_CR44","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1038\/s41418-020-0516-1","volume":"27","author":"Y Hu","year":"2020","unstructured":"Hu Y, Ouyang Z, Sui X et al (2020) Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development. Cell Death Differ 27:2468\u20132483. https:\/\/doi.org\/10.1038\/s41418-020-0516-1","journal-title":"Cell Death Differ"},{"key":"11361_CR45","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/s41419-021-04272-9","volume":"12","author":"H Mu","year":"2021","unstructured":"Mu H, Zhang T, Yang Y et al (2021) METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice. Cell Death Dis 12:989. https:\/\/doi.org\/10.1038\/s41419-021-04272-9","journal-title":"Cell Death Dis"},{"key":"11361_CR46","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/biolre\/ioac112","volume":"107","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Wu W, Chen S et al (2022) Mettl3 downregulation in germinal vesicle oocytes inhibits mRNA decay and the first polar body extrusion during maturation. Biol Reprod 107:765\u2013778. https:\/\/doi.org\/10.1093\/biolre\/ioac112","journal-title":"Biol Reprod"},{"key":"11361_CR47","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.1038\/s41598-018-24395-y","volume":"8","author":"X-X Yu","year":"2018","unstructured":"Yu X-X, Liu Y-H, Liu X-M et al (2018) Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes. Sci Rep 8:6132. https:\/\/doi.org\/10.1038\/s41598-018-24395-y","journal-title":"Sci Rep"},{"key":"11361_CR48","doi-asserted-by":"publisher","first-page":"6532","DOI":"10.1038\/s41467-023-42302-6","volume":"14","author":"L Bai","year":"2023","unstructured":"Bai L, Xiang Y, Tang M et al (2023) ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N 6-methyladenosine methylation. Nat Commun 14:6532. https:\/\/doi.org\/10.1038\/s41467-023-42302-6","journal-title":"Nat Commun"},{"key":"11361_CR49","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1007\/s43032-024-01632-6","volume":"31","author":"L Li","year":"2024","unstructured":"Li L, Yang L, Shen L et al (2024) Fat mass and obesity-associated protein regulates Granulosa cell aging by targeting matrix metalloproteinase-2 gene via an N6-Methyladenosine-YT521-B homology domain family member 2-dependent pathway in aged mice. Reprod Sci 31:3498\u20133511. https:\/\/doi.org\/10.1007\/s43032-024-01632-6","journal-title":"Reprod Sci"},{"key":"11361_CR50","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.molcel.2017.08.003","volume":"67","author":"I Ivanova","year":"2017","unstructured":"Ivanova I, Much C, Di Giacomo M et al (2017) The RNA m 6 A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Mol Cell 67:1059\u20131067. https:\/\/doi.org\/10.1016\/j.molcel.2017.08.003","journal-title":"Mol Cell"},{"key":"11361_CR51","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.molcel.2017.09.021","volume":"68","author":"MN Wojtas","year":"2017","unstructured":"Wojtas MN, Pandey RR, Mendel M et al (2017) Regulation of m6A transcripts by the 3\u02b9\u21925\u02b9 RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline. Mol Cell 68:374\u2013387. https:\/\/doi.org\/10.1016\/j.molcel.2017.09.021","journal-title":"Mol Cell"},{"key":"11361_CR52","doi-asserted-by":"publisher","first-page":"e1007412","DOI":"10.1371\/journal.pgen.1007412","volume":"14","author":"SD Kasowitz","year":"2018","unstructured":"Kasowitz SD, Ma J, Anderson SJ et al (2018) Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet 14:e1007412. https:\/\/doi.org\/10.1371\/journal.pgen.1007412","journal-title":"PLoS Genet"},{"key":"11361_CR53","doi-asserted-by":"publisher","first-page":"144810","DOI":"10.1016\/j.gene.2020.144810","volume":"753","author":"M Zeng","year":"2020","unstructured":"Zeng M, Dai X, Liang Z et al (2020) Critical roles of mRNA m6A modification and YTHDC2 expression for meiotic initiation and progression in female germ cells. Gene 753:144810. https:\/\/doi.org\/10.1016\/j.gene.2020.144810","journal-title":"Gene"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11361-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11361-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11361-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:27:06Z","timestamp":1766143626000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11361-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11361"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11361-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"216"}}