{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T13:36:59Z","timestamp":1766929019935,"version":"3.48.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hunan Provincial Natural Science Fund project","award":["2024JJ5223"],"award-info":[{"award-number":["2024JJ5223"]}]},{"name":"Hunan Provincial Natural Science Fund project","award":["2025JJ90018"],"award-info":[{"award-number":["2025JJ90018"]}]},{"name":"Hunan Provincial Natural Science Fund project","award":["2024JJ5223"],"award-info":[{"award-number":["2024JJ5223"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine","award":["A2023044"],"award-info":[{"award-number":["A2023044"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine","award":["A2023044"],"award-info":[{"award-number":["A2023044"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82374323"],"award-info":[{"award-number":["82374323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11379-1","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T13:32:37Z","timestamp":1766928757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["circ-Ttc3 alleviates LPS-induced neuronal injury via stabilizing RBFOX1 to inhibit inflammation and oxidative stress"],"prefix":"10.1007","volume":"53","author":[{"given":"Yihui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-4690","authenticated-orcid":false,"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"11379_CR1","volume-title":"StatPearls","author":"K Margetis","year":"2025","unstructured":"Margetis K, Das JM, Emmady PD (2025) Spinal Cord Injuries. StatPearls. StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC., Treasure Island (FL)"},{"key":"11379_CR2","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS et al (2017) Traumatic spinal cord injury. Nat Rev Dis Primers 3:17018","journal-title":"Nat Rev Dis Primers"},{"key":"11379_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207533","author":"A Anjum","year":"2020","unstructured":"Anjum A et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21207533","journal-title":"Int J Mol Sci"},{"key":"11379_CR4","doi-asserted-by":"publisher","first-page":"1330678","DOI":"10.3389\/fimmu.2024.1330678","volume":"15","author":"Z Yin","year":"2024","unstructured":"Yin Z et al (2024) ROS: executioner of regulating cell death in spinal cord injury. Front Immunol 15:1330678","journal-title":"Front Immunol"},{"issue":"10","key":"11379_CR5","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1002\/jnr.25221","volume":"101","author":"M Yu","year":"2023","unstructured":"Yu M et al (2023) Oxidative stress following spinal cord injury: from molecular mechanisms to therapeutic targets. J Neurosci Res 101(10):1538\u20131554","journal-title":"J Neurosci Res"},{"key":"11379_CR6","doi-asserted-by":"crossref","unstructured":"Lukacova N et al (2021) Glial-Neuronal interactions in pathogenesis and treatment of spinal cord injury. Int J Mol Sci 22(24):13577","DOI":"10.3390\/ijms222413577"},{"issue":"2","key":"11379_CR7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.expneurol.2011.10.010","volume":"234","author":"YS Gwak","year":"2012","unstructured":"Gwak YS et al (2012) Spatial and Temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats. Exp Neurol 234(2):362\u2013372","journal-title":"Exp Neurol"},{"key":"11379_CR8","doi-asserted-by":"crossref","unstructured":"Simpson DSA, Oliver PL (2020) ROS generation in microglia: Understanding oxidative stress and inflammation in neurodegenerative disease. Antioxid (Basel) 9(8):743","DOI":"10.3390\/antiox9080743"},{"key":"11379_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12575-020-00122-8","volume":"22","author":"PT Mumtaz","year":"2020","unstructured":"Mumtaz PT et al (2020) Deep insights in circular rnas: from biogenesis to therapeutics. Biol Proced Online 22:10","journal-title":"Biol Proced Online"},{"key":"11379_CR10","doi-asserted-by":"publisher","first-page":"629593","DOI":"10.3389\/fmolb.2021.629593","volume":"8","author":"ML Li","year":"2021","unstructured":"Li ML, Wang W, Jin ZB (2021) Circular RNAs in the central nervous system. Front Mol Biosci 8:629593","journal-title":"Front Mol Biosci"},{"key":"11379_CR11","doi-asserted-by":"publisher","first-page":"110251","DOI":"10.1016\/j.biopha.2020.110251","volume":"128","author":"Y Ma","year":"2020","unstructured":"Ma Y, Liu Y, Jiang Z (2020) CircRNAs: A new perspective of biomarkers in the nervous system. Biomed Pharmacother 128:110251","journal-title":"Biomed Pharmacother"},{"key":"11379_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jot.2021.06.001","volume":"30","author":"P Peng","year":"2021","unstructured":"Peng P et al (2021) The emerging role of circular RNAs in spinal cord injury. J Orthop Translat 30:1\u20135","journal-title":"J Orthop Translat"},{"key":"11379_CR13","doi-asserted-by":"publisher","first-page":"119233","DOI":"10.1016\/j.lfs.2021.119233","volume":"272","author":"X Ma","year":"2021","unstructured":"Ma X et al (2021) Effects of circular RNA Ttc3\/miR-148a\/Rcan2 axis on inflammation and oxidative stress in rats with acute kidney injury induced by sepsis. Life Sci 272:119233","journal-title":"Life Sci"},{"issue":"3","key":"11379_CR14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/iub.2236","volume":"72","author":"L Yu","year":"2020","unstructured":"Yu L et al (2020) Circular RNA circ-Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR-449a. IUBMB Life 72(3):505\u2013514","journal-title":"IUBMB Life"},{"issue":"3","key":"11379_CR15","first-page":"292","volume":"21","author":"G Li","year":"2018","unstructured":"Li G et al (2018) MiR-103 alleviates autophagy and apoptosis by regulating SOX2 in LPS-injured PC12 cells and SCI rats. Iran J Basic Med Sci 21(3):292\u2013300","journal-title":"Iran J Basic Med Sci"},{"issue":"8","key":"11379_CR16","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/1440-1681.13523","volume":"48","author":"Y Hou","year":"2021","unstructured":"Hou Y et al (2021) The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2. Clin Exp Pharmacol Physiol 48(8):1171\u20131181","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"11379_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.21037\/atm-22-542","volume":"10","author":"Q Lin","year":"2022","unstructured":"Lin Q et al (2022) Involvement of NEAT1\/PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM(2.5). Ann Transl Med 10(6):277","journal-title":"Ann Transl Med"},{"issue":"1","key":"11379_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13046-017-0539-8","volume":"36","author":"F Gao","year":"2017","unstructured":"Gao F et al (2017) CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing \u03b2-catenin. J Exp Clin Cancer Res 36(1):70","journal-title":"J Exp Clin Cancer Res"},{"key":"11379_CR19","doi-asserted-by":"publisher","first-page":"102053","DOI":"10.1016\/j.jchemneu.2021.102053","volume":"119","author":"BX Nie","year":"2022","unstructured":"Nie BX et al (2022) Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. J Chem Neuroanat 119:102053","journal-title":"J Chem Neuroanat"},{"issue":"42","key":"11379_CR20","doi-asserted-by":"publisher","first-page":"e2407132","DOI":"10.1002\/advs.202407132","volume":"11","author":"J Lou","year":"2024","unstructured":"Lou J et al (2024) TRIM56 modulates YBX1 degradation to ameliorate ZBP1-Mediated neuronal PANoptosis in spinal cord injury. Adv Sci (Weinh) 11(42):e2407132","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"11379_CR21","doi-asserted-by":"publisher","first-page":"e00309","DOI":"10.1016\/j.neurot.2023.e00309","volume":"21","author":"L He","year":"2024","unstructured":"He L et al (2024) Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain. Neurotherapeutics 21(1):e00309","journal-title":"Neurotherapeutics"},{"issue":"10","key":"11379_CR22","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/jnr.23266","volume":"91","author":"N Hamada","year":"2013","unstructured":"Hamada N et al (2013) Biochemical and morphological characterization of A2BP1 in neuronal tissue. J Neurosci Res 91(10):1303\u20131311","journal-title":"J Neurosci Res"},{"key":"11379_CR23","doi-asserted-by":"crossref","unstructured":"Freyermuth-Trujillo X et al (2022) Inflammation: A target for treatment in spinal cord injury. Cells 11(17):2692","DOI":"10.3390\/cells11172692"},{"key":"11379_CR24","doi-asserted-by":"publisher","first-page":"107907","DOI":"10.1016\/j.neuropharm.2019.107907","volume":"172","author":"CL Eastman","year":"2020","unstructured":"Eastman CL, D\u2019Ambrosio R, Ganesh T (2020) Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury. Neuropharmacology 172:107907","journal-title":"Neuropharmacology"},{"key":"11379_CR25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.yjmcc.2019.03.007","volume":"130","author":"L Cai","year":"2019","unstructured":"Cai L et al (2019) Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b. J Mol Cell Cardiol 130:10\u201322","journal-title":"J Mol Cell Cardiol"},{"key":"11379_CR26","doi-asserted-by":"crossref","unstructured":"Sui X, Wang Y, Liu H (2021) hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression. Mol Med Rep 24(3):654","DOI":"10.3892\/mmr.2021.12293"},{"issue":"7","key":"11379_CR27","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/ng.841","volume":"43","author":"LT Gehman","year":"2011","unstructured":"Gehman LT et al (2011) The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43(7):706\u2013711","journal-title":"Nat Genet"},{"issue":"19","key":"11379_CR28","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1093\/hmg\/dds240","volume":"21","author":"BL Fogel","year":"2012","unstructured":"Fogel BL et al (2012) RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet 21(19):4171\u20134186","journal-title":"Hum Mol Genet"},{"issue":"6","key":"11379_CR29","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s10038-004-0145-4","volume":"49","author":"K Bhalla","year":"2004","unstructured":"Bhalla K et al (2004) The de novo chromosome 16 translocations of two patients with abnormal phenotypes (mental retardation and epilepsy) disrupt the A2BP1 gene. J Hum Genet 49(6):308\u2013311","journal-title":"J Hum Genet"},{"issue":"7","key":"11379_CR30","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ng.162","volume":"40","author":"B Xu","year":"2008","unstructured":"Xu B et al (2008) Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet 40(7):880\u2013885","journal-title":"Nat Genet"},{"issue":"5823","key":"11379_CR31","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1126\/science.1138659","volume":"316","author":"J Sebat","year":"2007","unstructured":"Sebat J et al (2007) Strong association of de novo copy number mutations with autism. Science 316(5823):445\u2013449","journal-title":"Science"},{"key":"11379_CR32","doi-asserted-by":"crossref","unstructured":"Leggieri A et al (2025) rbfox1 LoF mutants show disrupted bdnf\/trkb2 and crhb\/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood. Transl Psychiatry 15(1):519.","DOI":"10.1038\/s41398-025-03703-x"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11379-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11379-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11379-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T13:32:38Z","timestamp":1766928758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11379-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,28]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11379"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11379-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,28]]},"assertion":[{"value":"7 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Hunan University of Traditional Chinese Medicine. (Approval: HNUCM21-2311-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"219"}}