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We hypothesized that the tumour microenvironment (TME) of the breast had lower levels of ADIPOQ and ADIPOR1 in postmenopausal women with obesity than in those with a normal BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Twenty women with normal body mass index (BMI) and 20 with obesity, all of them postmenopausal and with breast cancer (BC) were included. We obtained during surgery fresh breast tumour tissue and a fragment of breast adipose tissue adjacent to the tumour and analyzed the levels of adiponectin (ADIPOQ) and its receptor ADIPOR1 by Western blot. Statistical power of the study was &gt;\u200980% with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05ADIPOR1 protein levels were higher in breast tumour tissue\n                      <jats:italic>versus<\/jats:italic>\n                      breast adipose tissue adjacent to the tumour in postmenopausal women with normal BMI and postmenopausal women with obesity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0012 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001, respectively). Moreover, we observed higher ADIPOR1 levels only in breast adipose tissue adjacent to the tumour in postmenopausal women with obesity and tumour size\u2009&gt;\u20092.0\u00a0cm and clinical stage II\/III (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025, respectively) versus postmenopausal women with a normal BMI. We did not observe differences in ADIPOQ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADIPOR1 levels were higher in breast tumour tissue compared to breast adipose tissue adjacent to the tumour in both postmenopausal women with normal BMI or with obesity. Besides, ADIPOR1 levels were higher in breast adipose tissue adjacent to the tumour of postmenopausal women and obesity, with a more aggressive breast tumour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-025-11392-4","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T13:32:38Z","timestamp":1766928758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adiponectin 1 receptor is increased but not adiponectin levels in the tumour microenvironment of postmenopausal women with breast cancer"],"prefix":"10.1007","volume":"53","author":[{"given":"Diego","family":"Garc\u00eda-Mata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Tenorio-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-2002","authenticated-orcid":false,"given":"Ram\u00f3n Mauricio","family":"Coral-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"D\u00e1valos-Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Bautista-Pi\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-480X","authenticated-orcid":false,"given":"Patricia","family":"Canto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"11392_CR1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0140-6736(22)01438-6","volume":"400","author":"GBDCRF Collaborators","year":"2022","unstructured":"Collaborators GBDCRF (2022) The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the global burden of disease study 2019. 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Research Committee and Research Ethics Committee of the Instituto de Enfermedades de la Mama (FUCAM), Mexico (number CEI\/PI-19-11\/2020) and Research Committee and Research Ethics Committee of the Faculty of Medicine, UNAM (number FMED\/CEI\/RMWC\/015\/2020) approved the study, and informed consent was obtained from all womrn participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"220"}}