{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:04:28Z","timestamp":1766995468901,"version":"3.48.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-037-032"],"award-info":[{"award-number":["NSTC 114-2314-B-037-032"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2320-B-037-015"],"award-info":[{"award-number":["NSTC 114-2320-B-037-015"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-DK(A)113003 and KMU-TB114009"],"award-info":[{"award-number":["KMU-DK(A)113003 and KMU-TB114009"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaohsiung Medical University Research Center","award":["KMU-TC114A04"],"award-info":[{"award-number":["KMU-TC114A04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-025-11399-x","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:37:22Z","timestamp":1766990242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excavatolide E triggers oxidative stress-associated apoptosis and DNA damage to inhibit bladder cancer cell proliferation"],"prefix":"10.1007","volume":"53","author":[{"given":"Che-Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsu-Ming","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Yin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Rong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Horng","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"11399_CR1","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN et al (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345","journal-title":"CA Cancer J Clin"},{"key":"11399_CR2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.annonc.2021.11.012","volume":"33","author":"T Powles","year":"2022","unstructured":"Powles T, Bellmunt J, Comperat E et al (2022) Bladder cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol 33:244\u2013258","journal-title":"Ann Oncol"},{"key":"11399_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.juro.2017.04.086","volume":"198","author":"SS Chang","year":"2017","unstructured":"Chang SS, Bochner BH, Chou R et al (2017) Treatment of non-metastatic muscle-invasive bladder cancer: AUA\/ASCO\/ASTRO\/SUO guideline. J Urol 198:552\u2013559","journal-title":"J Urol"},{"key":"11399_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12894-020-00733-z","volume":"20","author":"ARAH Hamid","year":"2020","unstructured":"Hamid ARAH, Ridwan FR, Parikesit D et al (2020) Meta-analysis of neoadjuvant chemotherapy compared to radical cystectomy alone in improving overall survival of muscle-invasive bladder cancer patients. BMC Urol 20:1\u20139","journal-title":"BMC Urol"},{"key":"11399_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/hlca.19870700108","volume":"70","author":"M D\u2019Ambrosio","year":"1987","unstructured":"D\u2019Ambrosio M, Fabbri D, Guerriero A et al (1987) Coralloidolide A and coralloidolide B, the first cembranoids from a mediterranean organism, the alcyonacean Alcyonium coralloides. Helv Chim Acta 70:63\u201370","journal-title":"Helv Chim Acta"},{"key":"11399_CR6","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1039\/C9QO01005J","volume":"6","author":"ZC Sun","year":"2019","unstructured":"Sun ZC, Zhu NL, Zhou M et al (2019) Clavipines A-C, antiproliferative meroterpenoids with a fused Azepine skeleton from the basidiomycete. Org Chem Front 6:3759\u20133765","journal-title":"Org Chem Front"},{"key":"11399_CR7","doi-asserted-by":"publisher","first-page":"116266","DOI":"10.1016\/j.bcp.2024.116266","volume":"225","author":"AR Gomes","year":"2024","unstructured":"Gomes AR, Tavares-da-Silva EJ, Costa SC et al (2024) Steroidal epoxides as anticancer agents in lung, prostate and breast cancers: the case of 1,2-epoxysteroids. Biochem Pharmacol 225:116266","journal-title":"Biochem Pharmacol"},{"key":"11399_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13020-023-00870-1","volume":"18","author":"F Cao","year":"2023","unstructured":"Cao F, Chu C, Qin JJ et al (2023) Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones. Chin Med 18:164","journal-title":"Chin Med"},{"key":"11399_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12935-022-02721-9","volume":"22","author":"P Dhyani","year":"2022","unstructured":"Dhyani P, Sati P, Sharma E et al (2022) Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies. Cancer Cell Int 22:305","journal-title":"Cancer Cell Int"},{"key":"11399_CR10","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1021\/np970553w","volume":"61","author":"JH Sheu","year":"1998","unstructured":"Sheu JH, Sung PJ, Cheng MC et al (1998) Novel cytotoxic diterpenes, excavatolides A-E, isolated from the Formosan Gorgonian Briareum excavatum. J Nat Prod 61:602\u2013608","journal-title":"J Nat Prod"},{"key":"11399_CR11","doi-asserted-by":"publisher","first-page":"14555","DOI":"10.1016\/S0040-4020(99)00931-X","volume":"55","author":"JH Sheu","year":"1999","unstructured":"Sheu JH, Sung PJ, Su JH et al (1999) Briaexcavatolides A\u2013J, new diterpenes from the Gorgonian Briareum excavatum. Tetrahedron 55:14555\u201314564","journal-title":"Tetrahedron"},{"key":"11399_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/tox.22235","volume":"32","author":"BK Velmurugan","year":"2017","unstructured":"Velmurugan BK, Yang HH, Sung PJ et al (2017) Excavatolide B inhibits nonsmall cell lung cancer proliferation by altering peroxisome proliferator activated receptor gamma expression and PTEN\/AKT\/NF-Kbeta expression. Environ Toxicol 32:290\u2013301","journal-title":"Environ Toxicol"},{"key":"11399_CR13","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3390\/ph15080917","volume":"15","author":"CW Yang","year":"2022","unstructured":"Yang CW, Chien TM, Yen CH et al (2022) Antibladder cancer effects of excavatolide C by inducing oxidative stress, apoptosis, and DNA damage in vitro. Pharmaceuticals (Basel) 15:917","journal-title":"Pharmaceuticals (Basel)"},{"key":"11399_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1186\/s12885-025-14276-9","volume":"25","author":"JP Shiau","year":"2025","unstructured":"Shiau JP, Yang CW, Liu W et al (2025) Excavatolide C has oxidative-stress-dependent antiproliferative and apoptotic effects against breast cancer cells. BMC Cancer 25:1023","journal-title":"BMC Cancer"},{"key":"11399_CR15","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1016\/j.tet.2008.01.023","volume":"64","author":"PJ Sung","year":"2008","unstructured":"Sung PJ, Lin MR, Su YD et al (2008) New Briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae). Tetrahedron 64:2596\u20132604","journal-title":"Tetrahedron"},{"key":"11399_CR16","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1002\/tox.22190","volume":"31","author":"JH Hung","year":"2016","unstructured":"Hung JH, Chen CY, Omar HA et al (2016) Reactive oxygen species mediate Terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins. Environ Toxicol 31:1888\u20131898","journal-title":"Environ Toxicol"},{"key":"11399_CR17","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/tox.22590","volume":"33","author":"CH Huang","year":"2018","unstructured":"Huang CH, Yeh JM, Chan WH (2018) Hazardous impacts of silver nanoparticles on mouse oocyte maturation and fertilization and fetal development through induction of apoptotic processes. Environ Toxicol 33:1039\u20131049","journal-title":"Environ Toxicol"},{"key":"11399_CR18","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/tox.22588","volume":"33","author":"TS Wang","year":"2018","unstructured":"Wang TS, Lin CP, Chen YP et al (2018) CYP450-mediated mitochondrial ROS production involved in Arecoline N-oxide-induced oxidative damage in liver cell lines. Environ Toxicol 33:1029\u20131038","journal-title":"Environ Toxicol"},{"key":"11399_CR19","doi-asserted-by":"publisher","first-page":"5318","DOI":"10.7150\/jca.97537","volume":"15","author":"WT Kuo","year":"2024","unstructured":"Kuo WT, Lee YC, Yang YF et al (2024) Sushi domain containing 2 dysfunction contributes to cancer progression in patients with bladder cancer. J Cancer 15:5318\u20135328","journal-title":"J Cancer"},{"key":"11399_CR20","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1158\/2767-9764.CRC-24-0433","volume":"5","author":"FJ Roa","year":"2025","unstructured":"Roa FJ, Roubelakis M, Paschidis K et al (2025) Repurposing Amiodarone for bladder cancer treatment. Cancer Res Commun 5:906\u2013920","journal-title":"Cancer Res Commun"},{"key":"11399_CR21","doi-asserted-by":"publisher","first-page":"102794","DOI":"10.1016\/j.tice.2025.102794","volume":"94","author":"CH Ho","year":"2025","unstructured":"Ho CH, Fan CK, Chu YC et al (2025) Effects of pterostilbene on inducing apoptosis in normal bladder and bladder cancer cells. Tissue Cell 94:102794","journal-title":"Tissue Cell"},{"key":"11399_CR22","doi-asserted-by":"publisher","first-page":"e68425","DOI":"10.1371\/journal.pone.0068425","volume":"8","author":"C Vignon","year":"2013","unstructured":"Vignon C, Debeissat C, Georget MT et al (2013) Flow cytometric quantification of all phases of the cell cycle and apoptosis in a two-color fluorescence plot. PLoS ONE 8:e68425","journal-title":"PLoS ONE"},{"key":"11399_CR23","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.3390\/antiox10071063","volume":"10","author":"TM Chien","year":"2021","unstructured":"Chien TM, Wu KH, Chuang YT et al (2021) Withaferin A triggers apoptosis and DNA damage in bladder cancer J82 cells through oxidative stress. Antioxid (Basel) 10:1063","journal-title":"Antioxid (Basel)"},{"key":"11399_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/molecules22030437","volume":"22","author":"CH Lee","year":"2017","unstructured":"Lee CH, Shih YL, Lee MH et al (2017) Bufalin induces apoptosis of human osteosarcoma U-2 OS cells through Endoplasmic reticulum stress, caspase- and mitochondria-dependent signaling pathways. Molecules 22:437","journal-title":"Molecules"},{"key":"11399_CR25","first-page":"169","volume":"38","author":"WH Chou","year":"2018","unstructured":"Chou WH, Liu KL, Shih YL et al (2018) Ouabain induces apoptotic cell death through caspase- and mitochondria-dependent pathways in human osteosarcoma U-2 OS cells. Anticancer Res 38:169\u2013178","journal-title":"Anticancer Res"},{"key":"11399_CR26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3390\/antiox11050841","volume":"11","author":"JP Shiau","year":"2022","unstructured":"Shiau JP, Chuang YT, Yang KH et al (2022) Brown algae-derived fucoidan exerts oxidative stress-dependent antiproliferation on oral cancer cells. Antioxid (Basel) 11:841","journal-title":"Antioxid (Basel)"},{"key":"11399_CR27","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3390\/md18080382","volume":"18","author":"YC Liu","year":"2020","unstructured":"Liu YC, Peng BR, Hsu KC et al (2020) 13-Acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the Keap1\/Nrf2\/p62\/SQSTM1 pathway: the need to move beyond classical concepts. Mar Drugs 18:382","journal-title":"Mar Drugs"},{"key":"11399_CR28","first-page":"361","volume":"2","author":"ME Kauffman","year":"2016","unstructured":"Kauffman ME, Kauffman MK, Traore K et al (2016) MitoSOX-based flow cytometry for detecting mitochondrial ROS. React Oxyg Species (Apex) 2:361\u2013370","journal-title":"React Oxyg Species (Apex)"},{"key":"11399_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R","volume":"31","author":"M van Engeland","year":"1998","unstructured":"van Engeland M, Nieland LJ, Ramaekers FC et al (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31:1\u20139","journal-title":"Cytometry"},{"key":"11399_CR30","doi-asserted-by":"publisher","first-page":"118688","DOI":"10.1016\/j.bbamcr.2020.118688","volume":"1867","author":"A Boice","year":"2020","unstructured":"Boice A, Bouchier-Hayes L (2020) Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res 1867:118688","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"11399_CR31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41388-021-02105-9","volume":"41","author":"X Hao","year":"2022","unstructured":"Hao X, Bu W, Lv G et al (2022) Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress. Oncogene 41:427\u2013443","journal-title":"Oncogene"},{"key":"11399_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.9734\/bpi\/nfmmr\/v16\/1816C","volume":"16","author":"AV Kuznetsov","year":"2021","unstructured":"Kuznetsov AV, Hagenbuchner J, Ausserlechner MJ (2021) ROS flashes in mitochondria occur concomitantly with inner mitochondrial membrane depolarization and mitochondrial calcium sparks. New Front Med Med Res 16:83\u2013104","journal-title":"New Front Med Med Res"},{"key":"11399_CR33","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3390\/nu10091137","volume":"10","author":"SH Kim","year":"2018","unstructured":"Kim SH, Kim H (2018) Inhibitory effect of Astaxanthin on oxidative stress-induced mitochondrial dysfunction- A mini-review. Nutrients 10:1137","journal-title":"Nutrients"},{"key":"11399_CR34","doi-asserted-by":"publisher","first-page":"5678","DOI":"10.1093\/nar\/gkn550","volume":"36","author":"A Kinner","year":"2008","unstructured":"Kinner A, Wu W, Staudt C et al (2008) Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36:5678\u20135694","journal-title":"Nucleic Acids Res"},{"key":"11399_CR35","first-page":"120","volume":"27","author":"A Valavanidis","year":"2009","unstructured":"Valavanidis A, Vlachogianni T, Fiotakis C (2009) 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:120\u2013139","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"11399_CR36","doi-asserted-by":"crossref","unstructured":"Cavalcanti Chipoline I et al (2020) Carolina Carvalho da Fonseca A, Ribeiro Machado da Costa G Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma. Bioorg Chem 101:103984","DOI":"10.1016\/j.bioorg.2020.103984"},{"key":"11399_CR37","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.4155\/fmc-2017-0205","volume":"10","author":"BC Zorzanelli","year":"2018","unstructured":"Zorzanelli BC, de Queiroz LN, Santos RM et al (2018) Potential cytotoxic and selective effect of new benzo[b]xanthenes against oral squamous cell carcinoma. Future Med Chem 10:1141\u20131157","journal-title":"Future Med Chem"},{"key":"11399_CR38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.13005\/bpj\/1608","volume":"12","author":"SA Aldossary","year":"2019","unstructured":"Aldossary SA (2019) Review on Pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin. Biomed Pharmacol J 12:7\u201315","journal-title":"Biomed Pharmacol J"},{"key":"11399_CR39","doi-asserted-by":"publisher","first-page":"1485283","DOI":"10.1155\/2017\/1485283","volume":"2017","author":"HR Teppo","year":"2017","unstructured":"Teppo HR, Soini Y, Karihtala P (2017) Reactive oxygen species-mediated mechanisms of action of targeted cancer therapy. Oxid Med Cell Longev 2017:1485283","journal-title":"Oxid Med Cell Longev"},{"key":"11399_CR40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.semcancer.2018.08.010","volume":"58","author":"JY Tang","year":"2019","unstructured":"Tang JY, Ou-Yang F, Hou MF et al (2019) Oxidative stress-modulating drugs have Preferential anticancer effects - involving the regulation of apoptosis, DNA damage, Endoplasmic reticulum stress, autophagy, metabolism, and migration. Semin Cancer Biol 58:109\u2013117","journal-title":"Semin Cancer Biol"},{"key":"11399_CR41","doi-asserted-by":"publisher","first-page":"8532940","DOI":"10.1155\/2021\/8532940","volume":"2021","author":"J Wang","year":"2021","unstructured":"Wang J, Sun D, Huang L et al (2021) Targeting reactive oxygen species capacity of tumor cells with repurposed drug as an anticancer therapy. Oxid Med Cell Longev 2021:8532940","journal-title":"Oxid Med Cell Longev"},{"key":"11399_CR42","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","volume":"1863","author":"M Redza-Dutordoir","year":"2016","unstructured":"Redza-Dutordoir M, Averill-Bates DA (2016) Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 1863:2977\u20132992","journal-title":"Biochim Biophys Acta"},{"key":"11399_CR43","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1128\/MCB.01644-09","volume":"30","author":"A Shibata","year":"2010","unstructured":"Shibata A, Barton O, Noon AT et al (2010) Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)\/M checkpoint arrest. Mol Cell Biol 30:3371\u20133383","journal-title":"Mol Cell Biol"},{"key":"11399_CR44","doi-asserted-by":"publisher","first-page":"4798","DOI":"10.1038\/sj.onc.1209608","volume":"25","author":"S Fulda","year":"2006","unstructured":"Fulda S, Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25:4798\u20134811","journal-title":"Oncogene"},{"key":"11399_CR45","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1158\/0008-5472.CAN-05-2657","volume":"66","author":"A Basu","year":"2006","unstructured":"Basu A, Castle VP, Bouziane M et al (2006) Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of Estrogen metabolite and ligands of death receptor family. Cancer Res 66:4309\u20134318","journal-title":"Cancer Res"},{"key":"11399_CR46","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3748\/wjg.v9.i6.1241","volume":"9","author":"LH Xu","year":"2003","unstructured":"Xu LH, Deng CS, Zhu YQ et al (2003) Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480. World J Gastroenterol 9:1241\u20131245","journal-title":"World J Gastroenterol"},{"key":"11399_CR47","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/path.1885","volume":"208","author":"R Kim","year":"2006","unstructured":"Kim R, Emi M, Tanabe K et al (2006) Regulation and interplay of apoptotic and non-apoptotic cell death. J Pathol 208:319\u2013326","journal-title":"J Pathol"},{"key":"11399_CR48","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","volume":"22","author":"K Hadian","year":"2023","unstructured":"Hadian K, Stockwell BR (2023) The therapeutic potential of targeting regulated non-apoptotic cell death. Nat Rev Drug Discov 22:723\u2013742","journal-title":"Nat Rev Drug Discov"},{"key":"11399_CR49","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/antiox11091845","volume":"11","author":"JP Shiau","year":"2022","unstructured":"Shiau JP, Chuang YT, Tang JY et al (2022) The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products. Antioxid (Basel) 11:1845","journal-title":"Antioxid (Basel)"},{"key":"11399_CR50","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.redox.2016.01.010","volume":"8","author":"F Ursini","year":"2016","unstructured":"Ursini F, Maiorino M, Forman HJ (2016) Redox homeostasis: the golden mean of healthy living. Redox Biol 8:205\u2013215","journal-title":"Redox Biol"},{"key":"11399_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/antiox8040091","volume":"8","author":"T Ahmad","year":"2019","unstructured":"Ahmad T, Suzuki YJ (2019) Juglone in oxidative stress and cell signaling. Antioxid (Basel) 8:91","journal-title":"Antioxid (Basel)"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11399-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-025-11399-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-025-11399-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:02:01Z","timestamp":1766995321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-025-11399-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11399"],"URL":"https:\/\/doi.org\/10.1007\/s11033-025-11399-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"type":"print","value":"0301-4851"},{"type":"electronic","value":"1573-4978"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The following are available online at\n                      \n                      , Fig.\n                      \n                      :\n                      1\n                      H NMR of EXCE measured at 28\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig.\n                      \n                      :\n                      1\n                      H NMR of EXCE measured at 0\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig. S3:\n                      1\n                      H NMR of EXCE measured at -20\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig. S4:\n                      1\n                      H NMR of EXCE measured at -40\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig. S5:\n                      1\n                      H NMR of EXCE measured at -60\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig. S6:\n                      1\n                      H NMR of EXCE measured at -80\u00a0\u00b0C (500\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ), Fig. S7:\n                      13\n                      C NMR of EXCE measured at -60\u00a0\u00b0C (125\u00a0MHz, Me\n                      2\n                      CO-\n                      d\n                      6\n                      ).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Supplementary Information"}}],"article-number":"234"}}