{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T02:22:03Z","timestamp":1770258123982,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011917","name":"Hormozgan University of Medical Sciences","doi-asserted-by":"publisher","award":["4030359"],"award-info":[{"award-number":["4030359"]}],"id":[{"id":"10.13039\/501100011917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11527-1","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:27:30Z","timestamp":1770208050000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of AKT1 and related ncRNAs hsa-miR-1286 and linc00242 as a putative molecular pathway in men with asthenozoospermia"],"prefix":"10.1007","volume":"53","author":[{"given":"Mohammadreza","family":"Saberiyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Mirfakhraie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Teimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naser","family":"Riazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azim","family":"Nejatizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"11527_CR1","unstructured":"World-Health-Organization (2024) Infertility"},{"issue":"2","key":"11527_CR2","first-page":"271","volume":"25","author":"CJ Krausz","year":"2011","unstructured":"Krausz CJ (2011) B.p., r.C. endocrinology, and metabolism. Male Infertility: Pathogenesis Clin Diagnosis 25(2):271\u2013285","journal-title":"Male Infertility: Pathogenesis Clin Diagnosis"},{"key":"11527_CR3","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine (2020). Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertility and sterility 113(3):533\u2013535","DOI":"10.1016\/j.fertnstert.2019.11.025"},{"issue":"6","key":"11527_CR4","first-page":"101472","volume":"34","author":"C Tu","year":"2020","unstructured":"Tu C et al (2020) Genetic Underpinnings Asthenozoospermia 34(6):101472","journal-title":"Genetic Underpinnings Asthenozoospermia"},{"key":"11527_CR5","doi-asserted-by":"crossref","unstructured":"Xu X et al (2018) A Familial study of twins with severe asthenozoospermia identified a homozygous SPAG17 mutation by whole-exome sequencing. Clin Genet 93(2):345\u2013349","DOI":"10.1111\/cge.13059"},{"key":"11527_CR6","doi-asserted-by":"crossref","unstructured":"Oud M et al (2021) Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders. Hum Reprod 36(9):2597\u20132611","DOI":"10.1093\/humrep\/deab099"},{"key":"11527_CR7","doi-asserted-by":"crossref","unstructured":"Kamel A et al (2022) Reduced expression of CFAP44 and CFAP44-AS1 May affect sperm motility and morphology. Andrologia 54(7):e14447","DOI":"10.1111\/and.14447"},{"key":"11527_CR8","doi-asserted-by":"crossref","unstructured":"Saberiyan M et al (2023) Circular RNAs: novel biomarkers in spermatogenesis defects and male infertility. Reprod Sci 30(1):62\u201371","DOI":"10.1007\/s43032-022-00885-3"},{"key":"11527_CR9","doi-asserted-by":"crossref","unstructured":"Kamel A et al (2022) DNAH5 gene and its correlation with linc02220 expression and sperm characteristics. Mol Biol Rep 49(10):9365\u20139372","DOI":"10.1007\/s11033-022-07787-2"},{"issue":"1","key":"11527_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s43042-024-00512-7","volume":"25","author":"D Junahar","year":"2024","unstructured":"Junahar D et al (2024) Potential biomarker signatures in male infertility: integrative genomic analysis. Egypt J Med Hum Genet 25(1):39","journal-title":"Egypt J Med Hum Genet"},{"issue":"D1","key":"11527_CR11","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa M et al (2025) KEGG: biological systems database as a model of the real world. Nucleic Acids Res 53(D1):D672\u2013d677","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"11527_CR12","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa M (2019) Toward Understanding the origin and evolution of cellular organisms. Protein Sci 28(11):1947\u20131951","journal-title":"Protein Sci"},{"issue":"D1","key":"11527_CR13","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","volume":"42","author":"J-H Li","year":"2013","unstructured":"Li J-H et al (2013) StarBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein\u2013RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 42(D1):D92\u2013D97","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"11527_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.4103\/aja.aja_46_20","volume":"22","author":"X-H Li","year":"2020","unstructured":"Li X-H et al (2020) Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility. Asian J Androl 22(6):583\u2013589","journal-title":"Asian J Androl"},{"key":"11527_CR15","doi-asserted-by":"crossref","unstructured":"Aitken RJ et al (2022) Male infertility and oxidative stress: A focus on the underlying mechanisms. Antioxid (Basel), 11(2): 306","DOI":"10.3390\/antiox11020306"},{"issue":"8","key":"11527_CR16","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.32604\/biocell.2023.030379","volume":"47","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Yang W (2023) The effects of hormone-mediated PI3K\/AKT signaling on spermatogenesis in Sertoli cells. Biocell 47(8):1709\u20131725","journal-title":"Biocell"},{"key":"11527_CR17","doi-asserted-by":"crossref","unstructured":"Gallardo Bolanos JM et al (2014) Phosphorylated AKT preserves stallion sperm viability and motility by inhibiting caspases 3 and 7.Reproduction 148(2):221\u2013235","DOI":"10.1530\/REP-13-0191"},{"key":"11527_CR18","doi-asserted-by":"crossref","unstructured":"Wang S et al (2021) Bacterial infections affect male fertility: A focus on the oxidative stress-autophagy axis. Front Cell Dev Biol 9:727812","DOI":"10.3389\/fcell.2021.727812"},{"issue":"1","key":"11527_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/1933719111424449","volume":"19","author":"ST Kim","year":"2012","unstructured":"Kim ST, Omurtag K, Moley KH (2012) Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-\/- and Akt2-\/- testes and sperm. Reprod Sci 19(1):31\u201342","journal-title":"Reprod Sci"},{"issue":"1","key":"11527_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.reprotox.2010.09.012","volume":"31","author":"J Santos-Ahmed","year":"2011","unstructured":"Santos-Ahmed J et al (2011) Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil. Reprod Toxicol 31(1):17\u201325","journal-title":"Reprod Toxicol"},{"issue":"1","key":"11527_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12935-020-01369-7","volume":"20","author":"X Zhong","year":"2020","unstructured":"Zhong X et al (2020) Activation of the LINC00242\/miR-141\/FOXC1 axis underpins the development of gastric cancer. Cancer Cell Int 20(1):272","journal-title":"Cancer Cell Int"},{"issue":"1","key":"11527_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s10020-020-00259-y","volume":"27","author":"P Deng","year":"2021","unstructured":"Deng P et al (2021) LINC00242\/miR-1-3p\/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis. Mol Med 27(1):9","journal-title":"Mol Med"},{"issue":"9","key":"11527_CR23","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1097\/MIB.0000000000000883","volume":"22","author":"A Oikonomopoulos","year":"2016","unstructured":"Oikonomopoulos A et al (2016) Identification of Circulating MicroRNA signatures in crohn\u2019s disease using the Nanostring nCounter technology. Inflamm Bowel Dis 22(9):2063\u20132069","journal-title":"Inflamm Bowel Dis"},{"key":"11527_CR24","doi-asserted-by":"crossref","unstructured":"Yang J et al (2024) Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012. Heliyon, 10(9): e30555","DOI":"10.1016\/j.heliyon.2024.e30555"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11527-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11527-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11527-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:27:32Z","timestamp":1770208052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11527-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11527"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11527-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of Hormozgan University of Medical Sciences approved the study procedures (IR.HUMS.REC.1403.299), and all participating patients gave their informed consent. Demographic data were collected from patient records. This research was carried out in compliance with the Declaration of Helsinki (Association, 2019).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent for participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"358"}}