{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:21:06Z","timestamp":1793449266065,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR47726\/CMD\/150\/26\/2023"],"award-info":[{"award-number":["BT\/PR47726\/CMD\/150\/26\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11561-z","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:27:50Z","timestamp":1770971270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Xmu-mp-1 attenuates streptozotocin-induced neurotoxicity in SH-SY5Y cells: potential role of Hippo pathway modulation"],"prefix":"10.1007","volume":"53","author":[{"given":"Manas Ranjan","family":"Sahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Hilal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7804","authenticated-orcid":false,"given":"Amal Chandra","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"11561_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2022.742408","volume":"14","author":"MB Abubakar","year":"2022","unstructured":"Abubakar MB, Sanusi KO, Ugusman A, Mohamed W, Kamal H, Ibrahim NH, Khoo CS, Kumar J (2022) Alzheimer\u2019s disease: an update and insights into Pathophysiology, front. Aging Neurosci 14:1\u201316. https:\/\/doi.org\/10.3389\/fnagi.2022.742408","journal-title":"Aging Neurosci"},{"key":"11561_CR2","doi-asserted-by":"publisher","first-page":"7355","DOI":"10.1007\/s12035-019-1605-3","volume":"56","author":"LM de Medeiros","year":"2019","unstructured":"de Medeiros LM, De Bastiani MA, Rico EP, Schonhofen P, Pfaffenseller B, Wollenhaupt-Aguiar B, Grun L, Barb\u00e9-Tuana F, Zimmer ER, Castro MAA, Parsons RB, Klamt F (2019) Cholinergic differentiation of human neuroblastoma SH-SY5Y cell line and its potential use as an in vitro model for alzheimer\u2019s disease studies. Mol Neurobiol 56:7355\u20137367. https:\/\/doi.org\/10.1007\/s12035-019-1605-3","journal-title":"Mol Neurobiol"},{"key":"11561_CR3","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.bbrc.2004.05.075","volume":"319","author":"A J\u00e4ms\u00e4","year":"2004","unstructured":"J\u00e4ms\u00e4 A, Hasslund K, Cowburn RF, B\u00e4ckstr\u00f6m A, Vas\u00e4nge M (2004) The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for alzheimer\u2019s disease-like Tau phosphorylation. Biochem Biophys Res Commun 319:993\u20131000. https:\/\/doi.org\/10.1016\/j.bbrc.2004.05.075","journal-title":"Biochem Biophys Res Commun"},{"key":"11561_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","volume":"5","author":"GJ Biessels","year":"2006","unstructured":"Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5:64\u201374. https:\/\/doi.org\/10.1016\/S1474-4422(05)70284-2","journal-title":"Lancet Neurol"},{"key":"11561_CR5","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s12640-022-00563-x","volume":"40","author":"A Roy","year":"2022","unstructured":"Roy A, Sharma S, Nag TC, Katyal J, Gupta YK, Jain S (2022) Cognitive dysfunction and anxiety resulting from synaptic Downscaling, hippocampal Atrophy, and ventricular enlargement with intracerebroventricular streptozotocin injection in male Wistar rats. Neurotox Res 40:2179\u20132202. https:\/\/doi.org\/10.1007\/s12640-022-00563-x","journal-title":"Neurotox Res"},{"key":"11561_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2019.00629","volume":"13","author":"S Gabbouj","year":"2019","unstructured":"Gabbouj S, Ryh\u00e4nen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskaine H, Tanila H, Haapasalo A, Hiltunen M, Natunen T (2019) Altered insulin signaling in alzheimer\u2019s disease brain-special emphasis on pi3k-akt pathway. Front Neurosci 13:1\u20138. https:\/\/doi.org\/10.3389\/fnins.2019.00629","journal-title":"Front Neurosci"},{"key":"11561_CR7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuint.2017.11.012","volume":"113","author":"SK Mishra","year":"2018","unstructured":"Mishra SK, Singh S, Shukla S, Shukla R (2018) Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. Neurochem Int 113:56\u201368. https:\/\/doi.org\/10.1016\/j.neuint.2017.11.012","journal-title":"Neurochem Int"},{"key":"11561_CR8","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1007\/s11064-021-03269-2","volume":"46","author":"F Bagam\u00e9ry","year":"2021","unstructured":"Bagam\u00e9ry F, Varga K, Kecsm\u00e1r K, Vincze I, Sz\u00f6k\u0151 \u00c9, T\u00e1bi T (2021) The impact of differentiation on cytotoxicity and insulin sensitivity in streptozotocin treated SH-SY5Y cells. Neurochem Res 46:1350\u20131358. https:\/\/doi.org\/10.1007\/s11064-021-03269-2","journal-title":"Neurochem Res"},{"key":"11561_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fncel.2020.00235","volume":"14","author":"J Park","year":"2020","unstructured":"Park J, Won J, Seo J, Yeo H-G, Kim K, Kim YG, Jeon C-Y, Kam MK, Kim Y-H, Huh J-W (2020) Streptozotocin induces alzheimer\u2019s disease-like pathology in hippocampal neuronal cells via CDK5\/Drp1-mediated mitochondrial fragmentation. Front Cell Neurosci 14:235. https:\/\/doi.org\/10.3389\/fncel.2020.00235","journal-title":"Front Cell Neurosci"},{"key":"11561_CR10","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1038\/aps.2016.80","volume":"37","author":"X Guo","year":"2016","unstructured":"Guo X, Sun G, Zhou T, Xu X, Zhu Z, Rukachaisirikul V, Hu L, Shen X (2016) Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid \u03b2 production and clearance. Acta Pharmacol Sin 37:1281\u20131297. https:\/\/doi.org\/10.1038\/aps.2016.80","journal-title":"Acta Pharmacol Sin"},{"key":"11561_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fimmu.2020.00281","volume":"11","author":"J Cheng","year":"2020","unstructured":"Cheng J, Wang S, Dong Y, Yuan Z (2020) The role and regulatory mechanism of Hippo signaling components in the neuronal system. Front Immunol 11:281. https:\/\/doi.org\/10.3389\/fimmu.2020.00281","journal-title":"Front Immunol"},{"key":"11561_CR12","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1089\/dna.2019.5308","volume":"39","author":"J Qing","year":"2020","unstructured":"Qing J, Liu X, Wu Q, Zhou M, Zhang Y, Mazhar M, Huang X, Wang L, He F (2020) Hippo\/YAP pathway plays a critical role in effect of GDNF against A\u03b2-Induced inflammation in microglial cells. DNA Cell Biol 39:1064\u20131071. https:\/\/doi.org\/10.1089\/dna.2019.5308","journal-title":"DNA Cell Biol"},{"key":"11561_CR13","doi-asserted-by":"publisher","first-page":"e13465","DOI":"10.1111\/acel.13465","volume":"20","author":"X Xu","year":"2021","unstructured":"Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, Wu Q, Wu L, Wang X, Ma Y (2021) YAP prevents premature senescence of astrocytes and cognitive decline of alzheimer\u2019s disease through regulating CDK6 signaling. Aging Cell 20:e13465. https:\/\/doi.org\/10.1111\/acel.13465","journal-title":"Aging Cell"},{"key":"11561_CR14","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1080\/15384101.2020.1824448","volume":"19","author":"J Zheng","year":"2020","unstructured":"Zheng J, Yu H, Zhou A, Wu B, Liu J, Jia Y, Xiang L (2020) It takes two to tango: coupling of Hippo pathway and redox signaling in biological process. Cell Cycle 19:2760\u20132775. https:\/\/doi.org\/10.1080\/15384101.2020.1824448","journal-title":"Cell Cycle"},{"key":"11561_CR15","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s12975-019-00702-1","volume":"10","author":"P Zhang","year":"2019","unstructured":"Zhang P, Wang T, Zhang D, Zhang Z, Yuan S, Zhang J, Cao J, Li H, Li X, Shen H, Chen G (2019) Exploration of MST1-Mediated secondary brain injury induced by intracerebral hemorrhage in rats via Hippo signaling Pathway, transl. Stroke Res 10:729\u2013743. https:\/\/doi.org\/10.1007\/s12975-019-00702-1","journal-title":"Stroke Res"},{"key":"11561_CR16","doi-asserted-by":"publisher","unstructured":"Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med 8. https:\/\/doi.org\/10.1126\/scitranslmed.aaf2304","DOI":"10.1126\/scitranslmed.aaf2304"},{"key":"11561_CR17","doi-asserted-by":"publisher","first-page":"114574","DOI":"10.1016\/j.bcp.2021.114574","volume":"188","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Si Y-F, Hu W, Yan P, Yu Y (2021) Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice. Biochem Pharmacol 188:114574. https:\/\/doi.org\/10.1016\/j.bcp.2021.114574","journal-title":"Biochem Pharmacol"},{"key":"11561_CR18","doi-asserted-by":"publisher","unstructured":"Faizah Z, Amanda B, Ashari FY, Triastuti E, Oxtoby R, Rahaju AS, Aziz MA, Lusida MI, Oceandy D (2020) Treatment with mammalian Ste-20-like kinase 1\/2 (MST1\/2) inhibitor XMU-MP-1 improves glucose tolerance in Streptozotocin-Induced diabetes mice. Molecules 25. https:\/\/doi.org\/10.3390\/molecules25194381","DOI":"10.3390\/molecules25194381"},{"key":"11561_CR19","doi-asserted-by":"publisher","first-page":"6470957","DOI":"10.1155\/2018\/6470957","volume":"2018","author":"J Qu","year":"2018","unstructured":"Qu J, Zhao H, Li Q, Pan P, Ma K, Liu X, Feng H, Chen Y (2018) MST1 suppression reduces early brain injury by inhibiting the NF-\u03baB\/MMP-9 pathway after subarachnoid hemorrhage in mice. Behav Neurol 2018:6470957. https:\/\/doi.org\/10.1155\/2018\/6470957","journal-title":"Behav Neurol"},{"key":"11561_CR20","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41419-021-04203-8","volume":"12","author":"J Zhang","year":"2021","unstructured":"Zhang J, Xu X, Liu H, Jin L, Shen X, Xie C, Xiang W, Yang D, Feng W, Wang J, Wang M, Dong T, Qiu H, Wu L, Wang Y, Zhang X, Huang Z (2021) Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis. Cell Death Dis 12:907. https:\/\/doi.org\/10.1038\/s41419-021-04203-8","journal-title":"Cell Death Dis"},{"key":"11561_CR21","doi-asserted-by":"publisher","first-page":"103104","DOI":"10.1016\/j.redox.2024.103104","volume":"71","author":"W Huang","year":"2024","unstructured":"Huang W, Wu D, Cai C, Yao H, Tian Z (2024) Inhibition of MST1 ameliorates neuronal apoptosis via GSK3 \u03b2 \/ \u03b2 -TrCP \/ NRF2 pathway in spinal cord injury accompanied by diabetes. Redox Biol 71:103104. https:\/\/doi.org\/10.1016\/j.redox.2024.103104","journal-title":"Redox Biol"},{"key":"11561_CR22","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s10495-024-01975-0","volume":"29","author":"MR Sahu","year":"2024","unstructured":"Sahu MR, Ahmad MH, Mondal AC (2024) MST1 selective inhibitor Xmu-mp-1 ameliorates neuropathological changes in a rat model of sporadic alzheimer\u2019s disease by modulating Hippo-Wnt signaling crosstalk. Apoptosis 29:1824\u20131851. https:\/\/doi.org\/10.1007\/s10495-024-01975-0","journal-title":"Apoptosis"},{"key":"11561_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"11561_CR24","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/jnr.24551","volume":"98","author":"MR Sahu","year":"2020","unstructured":"Sahu MR, Mondal AC (2020) The emerging role of Hippo signaling in neurodegeneration. J Neurosci Res 98:796\u2013814. https:\/\/doi.org\/10.1002\/jnr.24551","journal-title":"J Neurosci Res"},{"key":"11561_CR25","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.3390\/cells10113144","volume":"10","author":"L Bruno","year":"2021","unstructured":"Bruno L, Karagil S, Mahmood A, Elbediwy A, Stolinski M, Mackenzie FE (2021) Mechanosensing and the Hippo pathway in microglia: a potential link to alzheimer\u2019s disease pathogenesis? Cells 10:3144. https:\/\/doi.org\/10.3390\/cells10113144","journal-title":"Cells"},{"key":"11561_CR26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.4014\/jmb.2101.01002","volume":"31","author":"S Lingappa","year":"2021","unstructured":"Lingappa S, Shivakumar MS, Manivasagam T, Somasundaram ST, Seedevi P (2021) Neuroprotective effect of Epalrestat on hydrogen peroxide-induced neurodegeneration in SH-SY5Y cellular model. J Microbiol Biotechnol 31:867. https:\/\/doi.org\/10.4014\/jmb.2101.01002","journal-title":"J Microbiol Biotechnol"},{"key":"11561_CR27","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.4103\/1673-5374.160076","volume":"10","author":"PK Kamat","year":"2015","unstructured":"Kamat PK (2015) Streptozotocin induced alzheimer\u2019s disease like changes and the underlying neural degeneration and regeneration mechanism. Neural Regen Res 10:1050. https:\/\/doi.org\/10.4103\/1673-5374.160076","journal-title":"Neural Regen Res"},{"key":"11561_CR28","doi-asserted-by":"publisher","first-page":"109421","DOI":"10.1016\/j.intimp.2022.109421","volume":"113","author":"S Qureshi","year":"2022","unstructured":"Qureshi S, Ali G, Muhammad T, Idrees M, Ullah S, Ali S, Ullah R, Khan R, Ul-haq Z, Haseeb A (2022) Thiadiazine-thione derivatives ameliorate STZ-induced diabetic neuropathy by regulating insulin and neuroinflammatory signaling. Int Immunopharmacol 113:109421. https:\/\/doi.org\/10.1016\/j.intimp.2022.109421","journal-title":"Int Immunopharmacol"},{"key":"11561_CR29","doi-asserted-by":"publisher","unstructured":"Gr\u00fcnblatt E, Marie C, Ohki Y, Peter GAS, Walitza S (2025) Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies : insights from streptozotocin and hypoglycaemic in vitro models. J Neural Transm (Vienna) 132(10): 1479\u20131491. https:\/\/doi.org\/10.1007\/s00702-025-02891-6","DOI":"10.1007\/s00702-025-02891-6"},{"key":"11561_CR30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.brainresbull.2021.07.015","volume":"175","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, Hu Y, Xia Q, Wang C, He L (2021) DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. Brain Res Bull 175:136\u2013149. https:\/\/doi.org\/10.1016\/j.brainresbull.2021.07.015","journal-title":"Brain Res Bull"},{"key":"11561_CR31","doi-asserted-by":"publisher","unstructured":"Sarathlal KC, Kakoty V, Marathe S, Chitkara D, Taliyan R (2021) Exploring the neuroprotective potential of Rosiglitazone embedded nanocarrier system on streptozotocin induced mice model of alzheimer\u2019s disease. Neurotox Res. 39(2):240\u2013255 https:\/\/doi.org\/10.1007\/s12640-020-00258-1","DOI":"10.1007\/s12640-020-00258-1"},{"key":"11561_CR32","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.bbadis.2018.10.037","volume":"1865","author":"S Pinho","year":"2019","unstructured":"Pinho S, Correia SC, Perry G, Francisco A (2019) Diminished O -GlcNAcylation in alzheimer \u2019 s disease is strongly correlated with mitochondrial anomalies, BBA - Mol. Basis Dis 1865:2048\u20132059","journal-title":"Basis Dis"},{"key":"11561_CR33","doi-asserted-by":"publisher","unstructured":"Shandilya S, Kesari KK (2021) Vitamin K2 modulates organelle damage and tauopathy induced by streptozotocin and menadione in SH-SY5Y cells. Antioxidants (Basel) 10(6):983. https:\/\/doi.org\/10.3390\/antiox10060983","DOI":"10.3390\/antiox10060983"},{"key":"11561_CR34","doi-asserted-by":"publisher","unstructured":"Plaschke K (2015) In vitro streptozotocin model for modeling Alzheimer-like changes: effect on amyloid precursor protein secretases and glycogen synthase kinase-3. J Neural Transm (Vienna).122(4):551\u20137. https:\/\/doi.org\/10.1007\/s00702-014-1319-7","DOI":"10.1007\/s00702-014-1319-7"},{"key":"11561_CR35","doi-asserted-by":"publisher","first-page":"110673","DOI":"10.1016\/j.neuropharm.2025.110673","volume":"280","author":"SS Kapse","year":"2025","unstructured":"Kapse SS, Migliore MM (2025) Neuropharmacology cytoprotective effects of gymnemic acid 1 in cellular models of neurodegeneration. Neuropharmacology 280:110673. https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110673","journal-title":"Neuropharmacology"},{"key":"11561_CR36","doi-asserted-by":"publisher","first-page":"106166","DOI":"10.1016\/j.tiv.2025.106166","volume":"111","author":"HS Bhumika","year":"2026","unstructured":"Bhumika HS, Pandareesh MD (2026) Toxicology in vitro neuromodulatory efficacy of Bacopa Monniera extract against streptozotocin-induced neuronal dysfunction in SH-SY5Y cells: implications for diabetic neuropathy. Toxicol Vitr 111:106166. https:\/\/doi.org\/10.1016\/j.tiv.2025.106166","journal-title":"Toxicol Vitr"},{"key":"11561_CR37","doi-asserted-by":"publisher","unstructured":"Jeong DJ, Um JH, Kim YY, Shin DJ, Im S, Lee KM, Lee YH, Lim DS, Kim D, Yun J (2024) The Mst1\/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress. Exp Mol Med 1\u201312. https:\/\/doi.org\/10.1038\/s12276-024-01198-y","DOI":"10.1038\/s12276-024-01198-y"},{"key":"11561_CR38","doi-asserted-by":"publisher","first-page":"120855","DOI":"10.1016\/j.lfs.2022.120855","volume":"306","author":"SK Beura","year":"2022","unstructured":"Beura SK, Dhapola R, Panigrahi AR, Yadav P, Reddy DH, Singh SK (2022) Redefining oxidative stress in alzheimer\u2019s disease: targeting platelet reactive oxygen species for novel therapeutic options. Life Sci 306:120855. https:\/\/doi.org\/10.1016\/j.lfs.2022.120855","journal-title":"Life Sci"},{"key":"11561_CR39","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1007\/s12035-015-9384-y","volume":"53","author":"PK Kamat","year":"2016","unstructured":"Kamat PK, Kalani A, Rai S, Tota SK, Kumar A, Ahmad AS (2016) Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic alzheimer\u2019s disease (sAD)-like pathology. Mol Neurobiol 53:4548\u20134562. https:\/\/doi.org\/10.1007\/s12035-015-9384-y","journal-title":"Mol Neurobiol"},{"key":"11561_CR40","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3760\/cma.j.issn.2095-4352.2018.04.002","volume":"30","author":"L Li","year":"2018","unstructured":"Li L, Dong L, Hui J, Gao F, Wang Q, Yang L, Zhang J, Yan J (2018) Effects of Hippo signaling on anti-oxidative stress of mesenchymal stem cells in vitro. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 30:296\u2013301. https:\/\/doi.org\/10.3760\/cma.j.issn.2095-4352.2018.04.002","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"11561_CR41","doi-asserted-by":"publisher","first-page":"103104","DOI":"10.1016\/j.redox.2024.103104","volume":"71","author":"W Huang","year":"2024","unstructured":"Huang W, Wu D, Cai C, Yao H, Tian Z, Yang Y, Pang M, Rong L, Liu B (2024) Inhibition of MST1 ameliorates neuronal apoptosis via GSK3\u03b2\/\u03b2-TrCP\/NRF2 pathway in spinal cord injury accompanied by diabetes. Redox Biol 71:103104. https:\/\/doi.org\/10.1016\/j.redox.2024.103104","journal-title":"Redox Biol"},{"key":"11561_CR42","doi-asserted-by":"publisher","unstructured":"Zhang Y, Gao W, Jing X, Shang W, Wang X, Yu S (2025) Melatonin regulates the MST1\/Nrf2 pathway to alleviate oxidative stress injury after hypoxic-ischemic brain damage in neonatal rats. Neurol Res 1\u201314. https:\/\/doi.org\/10.1080\/01616412.2025.2591278","DOI":"10.1080\/01616412.2025.2591278"},{"key":"11561_CR43","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.1007\/s10072-021-05551-1","volume":"42","author":"S Mani","year":"2021","unstructured":"Mani S, Sevanan M, Krishnamoorthy A, Sekar S (2021) A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in parkinson\u2019s disease. Neurol Sci 42:4459\u20134469. https:\/\/doi.org\/10.1007\/s10072-021-05551-1","journal-title":"Neurol Sci"},{"key":"11561_CR44","doi-asserted-by":"publisher","unstructured":"Cadonic C, Sabbir MG, Albensi BC (2016) Mechanisms of mitochondrial dysfunction in alzheimer \u2019 s disease. Mol Neurobiol 6078\u20136090. https:\/\/doi.org\/10.1007\/s12035-015-9515-5","DOI":"10.1007\/s12035-015-9515-5"},{"key":"11561_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Zhao F, Ma X, Perry G, Zhu X (2020) Mitochondria dysfunction in the pathogenesis of alzheimer\u2019s disease: recent advances. Mol Neurodegener 15:1\u201322. https:\/\/doi.org\/10.1186\/s13024-020-00376-6","journal-title":"Mol Neurodegener"},{"key":"11561_CR46","doi-asserted-by":"publisher","first-page":"103435","DOI":"10.1016\/j.redox.2024.103435","volume":"78","author":"S Ye","year":"2024","unstructured":"Ye S, Zhang M, Zheng X, Li S, Fan Y, Wang Y, Peng H, Chen S, Yang J, Tan L, Zhang M, Xie P, Li X, Luo N, Wang Z, Jin L, Wu X, Pan Y, Fan J, Zhou Y, Tang SCW, Li B, Chen W (2024) YAP1 preserves tubular mitochondrial quality control to mitigate diabetic kidney disease. Redox Biol 78:103435. https:\/\/doi.org\/10.1016\/j.redox.2024.103435","journal-title":"Redox Biol"},{"key":"11561_CR47","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/antiox11112167","volume":"11","author":"MC Jurc\u0103u","year":"2022","unstructured":"Jurc\u0103u MC, Andronie-Cioara FL, Jurc\u0103u A, Marcu F, \u0162i\u021b DM, Pa\u0219cal\u0103u N, Nistor-Cseppent\u00f6 DC (2022) The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of alzheimer\u2019s disease: therapeutic implications and future perspectives. Antioxidants 11:2167. https:\/\/doi.org\/10.3390\/antiox11112167","journal-title":"Antioxidants"},{"key":"11561_CR48","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/15569543.2022.2150646","volume":"42","author":"M Wan Chik","year":"2023","unstructured":"Wan Chik M, Ramli NA, Mohamad Nor Hazalin NA, Surindar GK, Singh (2023) Streptozotocin mechanisms and its role in rodent models for alzheimer\u2019s disease. Toxin Rev 42:491\u2013502. https:\/\/doi.org\/10.1080\/15569543.2022.2150646","journal-title":"Toxin Rev"},{"key":"11561_CR49","doi-asserted-by":"publisher","first-page":"117081","DOI":"10.1016\/j.bcp.2025.117081","volume":"239","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Jiang T, Li B, Sun G, Wang Y, Jiang Y, Hua P, Mu X, Wang W, Zhang Q (2025) Mst1 Inhibition mitigates steroid-induced femoral head osteonecrosis by modulating autophagy in bone microvascular endothelial cells. Biochem Pharmacol 239:117081. https:\/\/doi.org\/10.1016\/j.bcp.2025.117081","journal-title":"Biochem Pharmacol"},{"key":"11561_CR50","doi-asserted-by":"publisher","first-page":"e625","DOI":"10.1038\/cddis.2013.148","volume":"4","author":"P Sanphui","year":"2013","unstructured":"Sanphui P, Biswas SC (2013) FoxO3a is activated and executes neuron death via Bim in response to \u03b2-amyloid. Cell Death Dis 4:e625\u2013e612. https:\/\/doi.org\/10.1038\/cddis.2013.148","journal-title":"Cell Death Dis"},{"key":"11561_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-017-1678-3","volume":"17","author":"G Hao","year":"2017","unstructured":"Hao G, Lv T, Wu Y, Wang H, Xing W, Wang Y, Li C, Zhang Z, Wang Z, Wang W (2017) The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy. BMC Complement Altern Med 17:1\u201310. https:\/\/doi.org\/10.1186\/s12906-017-1678-3","journal-title":"BMC Complement Altern Med"},{"key":"11561_CR52","doi-asserted-by":"publisher","first-page":"408041","DOI":"10.3389\/fnins.2018.00679","volume":"12","author":"S-Y Yau","year":"2018","unstructured":"Yau S-Y, Lee TH-Y, Li A, Xu A, So K-F (2018) Adiponectin mediates running-restored hippocampal neurogenesis in streptozotocin-induced type 1 diabetes in mice. Front Neurosci 12:408041. https:\/\/doi.org\/10.3389\/fnins.2018.00679","journal-title":"Front Neurosci"},{"key":"11561_CR53","doi-asserted-by":"publisher","first-page":"102280","DOI":"10.1016\/j.pneurobio.2022.102280","volume":"214","author":"H Wang","year":"2022","unstructured":"Wang H, Shang Y, Wang E, Xu X, Zhang Q, Qian C, Yang Z, Wu S, Zhang T (2022) MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for alzheimer\u2019s disease. Prog Neurobiol 214:102280. https:\/\/doi.org\/10.1016\/j.pneurobio.2022.102280","journal-title":"Prog Neurobiol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11561-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11561-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11561-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:27:51Z","timestamp":1770971271000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11561-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11561"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11561-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"18 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not Applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}],"article-number":"384"}}