{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:16:39Z","timestamp":1788225399381,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11565-9","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:54:10Z","timestamp":1771660450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SNP-Driven LncRNA H19 dysregulation and CeRNA axis in breast and thyroid cancers among Pakistani females"],"prefix":"10.1007","volume":"53","author":[{"given":"Nafeesa","family":"Kainat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaisar","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqia Mehmood","family":"Baig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"11565_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"11565_CR2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s13193-021-01429-y","volume":"13","author":"JB Shank","year":"2022","unstructured":"Shank JB, Are C, Wenos CD (2022) Thyroid cancer: global burden and trends. Indian J Surg Oncol 13:40\u201345","journal-title":"Indian J Surg Oncol"},{"key":"11565_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14205117","author":"M Lu","year":"2022","unstructured":"Lu M, Liu H, Zheng B, Sun S, Chen C (2022) Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions. Cancers. https:\/\/doi.org\/10.3390\/cancers14205117","journal-title":"Cancers"},{"key":"11565_CR4","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1186\/s12885-022-10069-6","volume":"22","author":"MW Piek","year":"2022","unstructured":"Piek MW et al (2022) The co-occurrence of both breast-and differentiated thyroid cancer: incidence, association and clinical implications for daily practice. BMC Cancer 22:1018","journal-title":"BMC Cancer"},{"key":"11565_CR5","doi-asserted-by":"crossref","unstructured":"Li J et al (2023) Study on clinicopathological features and risk factors of patients with multiple primary breast cancers and thyroid disease. Mediators Inflamm 3133554","DOI":"10.1155\/2023\/3133554"},{"key":"11565_CR6","doi-asserted-by":"publisher","first-page":"1138149","DOI":"10.3389\/fendo.2023.1138149","volume":"14","author":"H Tan","year":"2023","unstructured":"Tan H, Wang S, Huang F, Tong Z (2023) Association between breast cancer and thyroid cancer risk: a two-sample Mendelian randomization study. Front Endocrinol (Lausanne) 14:1138149","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11565_CR7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20200032","volume":"65","author":"H Yan","year":"2021","unstructured":"Yan H, Bu P (2021) Non-coding RNA in cancer. Essays Biochem 65:625\u2013639","journal-title":"Essays Biochem"},{"key":"11565_CR8","doi-asserted-by":"publisher","first-page":"1275833","DOI":"10.3389\/fphar.2023.1275833","volume":"14","author":"C Zichittella","year":"2023","unstructured":"Zichittella C et al (2023) Long non-coding RNA H19 enhances the pro-apoptotic activity of ITF2357 (a histone deacetylase inhibitor) in colorectal cancer cells. Front Pharmacol 14:1275833","journal-title":"Front Pharmacol"},{"key":"11565_CR9","doi-asserted-by":"publisher","first-page":"4771","DOI":"10.7150\/jca.44833","volume":"11","author":"F Wang","year":"2020","unstructured":"Wang F et al (2020) LncRNA H19-Derived miR-675-3p promotes Epithelial-Mesenchymal transition and stemness in human pancreatic cancer cells by targeting the STAT3 pathway. J Cancer 11:4771\u20134782","journal-title":"J Cancer"},{"key":"11565_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jss.2021.08.004","volume":"269","author":"SJ O\u2019Brien","year":"2022","unstructured":"O\u2019Brien SJ et al (2022) Increased expression of long Non-coding RNA H19 is associated with colon cancer recurrence. J Surg Res 269:59\u201368","journal-title":"J Surg Res"},{"key":"11565_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12935-020-01261-4","volume":"20","author":"Y Li","year":"2020","unstructured":"Li Y et al (2020) LncRNA H19 promotes triple-negative breast cancer cells invasion and metastasis through the p53\/TNFAIP8 pathway. Cancer Cell Int 20:200","journal-title":"Cancer Cell Int"},{"key":"11565_CR12","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s10238-022-00853-w","volume":"23","author":"Y Sahin","year":"2023","unstructured":"Sahin Y (2023) LncRNA H19 is a potential biomarker and correlated with immune infiltration in thyroid carcinoma. Clin Exp Med 23:841\u2013851","journal-title":"Clin Exp Med"},{"key":"11565_CR13","doi-asserted-by":"publisher","first-page":"144317","DOI":"10.1016\/j.gene.2019.144317","volume":"729","author":"C Liu","year":"2020","unstructured":"Liu C et al (2020) Association between LncRNA H19 polymorphisms and cancer susceptibility based on a meta-analysis from 25 studies. Gene 729:144317","journal-title":"Gene"},{"key":"11565_CR14","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1080\/03630242.2022.2096748","volume":"62","author":"L Li","year":"2022","unstructured":"Li L et al (2022) Association between long non-coding RNA H19 polymorphisms and breast cancer risk: A meta-analysis. Women Health 62:565\u2013575","journal-title":"Women Health"},{"key":"11565_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.21608\/ejhm.2024.339913","volume":"94","author":"A Ragab","year":"2024","unstructured":"Ragab A, ELsobky H, El-Abd MG, Abdelsameea E, Salama M (2024) Long noncoding RNA H19 rs3741219 polymorphism and risk of hepatocellular carcinoma in Egyptian population. Egypt J Hosp Med 94:521\u2013528","journal-title":"Egypt J Hosp Med"},{"key":"11565_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12967-023-03894-1","volume":"21","author":"X Li","year":"2023","unstructured":"Li X, Li L, Wu J (2023) The members of the miR-148\/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5. J Transl Med 21:105","journal-title":"J Transl Med"},{"key":"11565_CR17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s13104-021-05647-z","volume":"14","author":"A Safi","year":"2021","unstructured":"Safi A et al (2021) The expression of miRNA-152-3p and miRNA-185 in tumor tissues versus margin tissues of patients with chemo-treated breast cancer. BMC Res Notes 14:234","journal-title":"BMC Res Notes"},{"key":"11565_CR18","doi-asserted-by":"publisher","first-page":"1139362","DOI":"10.3389\/fmed.2023.1139362","volume":"10","author":"VA Ruiz-Pozo","year":"2023","unstructured":"Ruiz-Pozo VA et al (2023) Differential MicroRNA expression for diagnosis and prognosis of papillary thyroid cancer. Front Med 10:1139362","journal-title":"Front Med"},{"key":"11565_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.semcancer.2020.05.010","volume":"72","author":"KK Wong","year":"2021","unstructured":"Wong KK (2021) DNMT1: A key drug target in triple-negative breast cancer. Semin Cancer Biol 72:198\u2013213","journal-title":"Semin Cancer Biol"},{"key":"11565_CR20","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1038\/s41388-022-02404-9","volume":"41","author":"Z Li","year":"2022","unstructured":"Li Z et al (2022) DNMT1-mediated epigenetic Silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability. Oncogene 41:3991\u20134002","journal-title":"Oncogene"},{"key":"11565_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12935-022-02463-8","volume":"22","author":"X Zhu","year":"2022","unstructured":"Zhu X et al (2022) DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation. Cancer Cell Int 22:56","journal-title":"Cancer Cell Int"},{"key":"11565_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s10142-024-01293-3","volume":"24","author":"Z Li","year":"2024","unstructured":"Li Z et al (2024) DNMT1\/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression. Funct Integr Genomics 24:12","journal-title":"Funct Integr Genomics"},{"key":"11565_CR23","doi-asserted-by":"publisher","first-page":"105021","DOI":"10.1016\/j.biosystems.2023.105021","volume":"233","author":"M Singh","year":"2023","unstructured":"Singh M, Kumar S (2023) Effect of single nucleotide polymorphisms on the structure of long noncoding RNAs and their interaction with RNA binding proteins. BioSystems 233:105021","journal-title":"BioSystems"},{"key":"11565_CR24","doi-asserted-by":"publisher","first-page":"108796","DOI":"10.1016\/j.intimp.2022.108796","volume":"109","author":"Q Wang","year":"2022","unstructured":"Wang Q et al (2022) Genetic predisposition to papillary thyroid carcinoma is mediated by a long non-coding RNA TINCR enhancer polymorphism. Int Immunopharmacol 109:108796","journal-title":"Int Immunopharmacol"},{"key":"11565_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030485","author":"J Karajovic","year":"2024","unstructured":"Karajovic J, MIR155HG (2024) Association of HOTAIR, TERC, miR-155, -196a2, and \u2013\u2009146a Genes Polymorphisms with Papillary Thyroid Cancer Susceptibility and Prognosis. Cancers. https:\/\/doi.org\/10.3390\/cancers16030485","journal-title":"Cancers"},{"key":"11565_CR26","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3390\/genes14050971","volume":"14","author":"C Mathias","year":"2023","unstructured":"Mathias C et al (2023) LncRNA-SNPs in a Brazilian breast cancer cohort: A Case-Control study. Genes (Basel) 14:971","journal-title":"Genes (Basel)"},{"key":"11565_CR27","doi-asserted-by":"publisher","first-page":"933","DOI":"10.2147\/PGPM.S422083","volume":"16","author":"J Dai","year":"2023","unstructured":"Dai J et al (2023) rs217727 of LncRNA H19 is associated with cervical cancer risk in the Chinese Han population. Pharmacogenomics and Personalized Medicine 16:933\u2013948","journal-title":"Pharmacogenomics and Personalized Medicine"},{"key":"11565_CR28","doi-asserted-by":"publisher","first-page":"100623","DOI":"10.1016\/j.genrep.2020.100623","volume":"19","author":"F Farzaneh","year":"2020","unstructured":"Farzaneh F, Salimi S, Razavi M, Rezaei M, Saravani M (2020) Association of H19 rs3741219 polymorphism with the susceptibility to uterine leiomyomas. Gene Rep 19:100623","journal-title":"Gene Rep"},{"key":"11565_CR29","doi-asserted-by":"publisher","first-page":"468","DOI":"10.30699\/jogcr.10.6.468","volume":"10","author":"F Sadeghi Moghadam","year":"2025","unstructured":"Sadeghi Moghadam F, Mokhtari MJ, Fattahi MJ (2025) LncRNA H19 genotypes and haplotypes in ovarian cancer patients. J Obstet Gynecol Cancer Res 10:468\u2013474","journal-title":"J Obstet Gynecol Cancer Res"},{"key":"11565_CR30","first-page":"377","volume":"11","author":"A Beiramzadeh","year":"2022","unstructured":"Beiramzadeh A, Heidari Z, Norouzi M, Saravani M (2022) Association between HOTAIR rs920778 and H19 rs3741219 polymorphisms with hashimoto\u2019s thyroiditis (HT) and graves\u2019 disease (GD). Rep Biochem Mol Biol 11:377\u2013385","journal-title":"Rep Biochem Mol Biol"},{"key":"11565_CR31","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1055\/a-2196-3511","volume":"56","author":"Y Wu","year":"2024","unstructured":"Wu Y et al (2024) LncRNA H19 influences cellular activities via the miR-454-3p\/BHLHE40 axis in anaplastic thyroid carcinoma. Horm Metab Res 56:392\u2013399","journal-title":"Horm Metab Res"},{"key":"11565_CR32","unstructured":"Zichittella C (2024) Study of the molecular mechanisms by which non-coding RNAs (IncH19 and miR-675) control tumor progression and resistance to drug therapy in colorectal cancer"},{"key":"11565_CR33","first-page":"159","volume":"11","author":"YY Fedorova","year":"2024","unstructured":"Fedorova YY et al (2024) MicroRNA miR-152 methylation in patients with ovarian cancer: prognostic potential analysis. Opera Med Physiol 11:159\u2013167","journal-title":"Opera Med Physiol"},{"key":"11565_CR34","doi-asserted-by":"crossref","unstructured":"Li J et al (2026). The miR-148\/152 Family Suppresses Apoptosis and Necroptosis for Cancer Evasion Through Direct RIPK1 Repression. Cell biology international, 50(2), e70131. https:\/\/doi.org\/10.1002\/cbin.70131","DOI":"10.1002\/cbin.70131"},{"key":"11565_CR35","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/hmg\/ddaf004","volume":"34","author":"C Wang","year":"2025","unstructured":"Wang C, Zhang G, Jiang Y, Bao G, Li C (2025) UBE2S, downregulated by miR-152-3p, facilitates prostate cancer progression through the PTEN-mediated AKT\/mTOR pathway. Hum Mol Genet 34:523\u2013532","journal-title":"Hum Mol Genet"},{"key":"11565_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21608\/jmalexu.2025.419542.1062","volume":"46","author":"NA Khalil","year":"2025","unstructured":"Khalil NA et al (2025) Potential role of Melatonin-Modulated Circulating miR-24, miR-152, and miR-497 as early liquid biopsy biomarkers in Egyptian breast cancer patients. J Med Res Inst 46:1\u20139","journal-title":"J Med Res Inst"},{"key":"11565_CR37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41420-024-01832-8","volume":"10","author":"Y Xia","year":"2024","unstructured":"Xia Y et al (2024) Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer. Cell Death Discov 10:76","journal-title":"Cell Death Discov"},{"key":"11565_CR38","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13148-024-01685-z","volume":"16","author":"X Hu","year":"2024","unstructured":"Hu X et al (2024) Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4. Clin Epigenetics 16:81","journal-title":"Clin Epigenetics"},{"key":"11565_CR39","doi-asserted-by":"publisher","first-page":"7235","DOI":"10.3390\/ijms24087235","volume":"24","author":"J Szczepanek","year":"2023","unstructured":"Szczepanek J, Skorupa M, Jarkiewicz-Tretyn J, Cybulski C, Tretyn A (2023) Harnessing epigenetics for breast cancer therapy: the role of DNA methylation, histone modifications, and MicroRNA. Int J Mol Sci 24:7235","journal-title":"Int J Mol Sci"},{"key":"11565_CR40","doi-asserted-by":"publisher","first-page":"782","DOI":"10.55730\/1300-0144.6027","volume":"55","author":"P Erco\u015fkun","year":"2025","unstructured":"Erco\u015fkun P, A\u011firba\u015fli D, Velidedeo\u011flu M, Seven M, Kalayci A (2025) HMGA2 associated ceRNA-HOTAIR pathway in breast cancer patients from clinicopathological perspective. Turkish J Med Sci 55:782\u2013791","journal-title":"Turkish J Med Sci"},{"key":"11565_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-023-01765-3","volume":"22","author":"GSR Raju","year":"2023","unstructured":"Raju GSR et al (2023) HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer. Mol Cancer 22:1\u201315","journal-title":"Mol Cancer"},{"key":"11565_CR42","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.21037\/tau-20-1250","volume":"10","author":"Y Fu","year":"2021","unstructured":"Fu Y, Sun S, Bi J, Kong C, Yin L (2021) Construction and analysis of a CeRNA network and patterns of immune infiltration in bladder cancer. Transl Androl Urol 10:1939\u20131955","journal-title":"Transl Androl Urol"},{"key":"11565_CR43","doi-asserted-by":"crossref","unstructured":"Lu W et al (2022) A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma. Comput. Math. Methods Med. 8504441 (2022)","DOI":"10.1155\/2022\/8504441"},{"key":"11565_CR44","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s11010-023-04804-1","volume":"479","author":"X Tang","year":"2024","unstructured":"Tang X et al (2024) Construction of lncRNA- and circRNA-associated CeRNA networks in the prostatic urethra of rats after simulating transurethral laser prostatectomy (TULP). Mol Cell Biochem 479:1363\u20131377","journal-title":"Mol Cell Biochem"},{"key":"11565_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-020-3520-z","volume":"21","author":"A Fiannaca","year":"2020","unstructured":"Fiannaca A, Paglia L, La, Rosa M, La, Rizzo R, Urso A (2020) MiRTissuece: extending mirtissue web service with the analysis of ceRNA-ceRNA interactions. BMC Bioinformatics 21:1\u201321","journal-title":"BMC Bioinformatics"},{"key":"11565_CR46","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s43066-023-00308-1","volume":"14","author":"G Salah","year":"2024","unstructured":"Salah G et al (2024) Diagnostic and prognostic significance of tissue LncRNA HOTAIR and hexokinase 2 mRNA expression in patients with pancreatic ductal adenocarcinoma. Egypt Liver J 14:6","journal-title":"Egypt Liver J"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11565-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11565-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11565-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:54:13Z","timestamp":1771660453000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11565-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11565"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11565-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"19 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the principles outlined in the Declaration of Helsinki. The Study was approved by the Institutional Ethics Committee (IEC) of PMAS Arid Agriculture University, Rawalpindi. (PMAS-AAUR\/IEC\/232 for studies involving humans.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"409"}}