{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:49Z","timestamp":1787237989864,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hainan Provincial Department of Science and Technology Key Project Social Development Fund","award":["ZDYF2024SHFZ092"],"award-info":[{"award-number":["ZDYF2024SHFZ092"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160011"],"award-info":[{"award-number":["82160011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation Platform for Academicians of Hainan Province"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11574-8","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:42:10Z","timestamp":1772631730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nicotine-induced mitophagy in bronchial epithelial cells and MYST1 downregulation in cigarette smoke\u2013exposed lungs: potential mechanisms of COPD progression"],"prefix":"10.1007","volume":"53","author":[{"given":"Kai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubing","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5196-9710","authenticated-orcid":false,"given":"Yipeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"issue":"4","key":"11574_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/jamp.2019.1576","volume":"33","author":"G Viegi","year":"2020","unstructured":"Viegi G, Maio S, Fasola S, Baldacci S (2020) Global burden of chronic respiratory diseases. J Aerosol Med Pulm Drug Deliv 33(4):171\u2013177. https:\/\/doi.org\/10.1089\/jamp.2019.1576","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"11574_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1404615","volume":"15","author":"J Xu","year":"2024","unstructured":"Xu J, Zeng Q, Li S, Su Q, Fan H (2024) Inflammation mechanism and research progress of COPD. Front Immunol 15:1404615. https:\/\/doi.org\/10.3389\/fimmu.2024.1404615","journal-title":"Front Immunol"},{"issue":"14","key":"11574_CR3","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1080\/14656566.2024.2409322","volume":"25","author":"MR Jacques","year":"2024","unstructured":"Jacques MR, Kuhn BT, Albertson TE (2024) Update on the pharmacological treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother 25(14):1903\u20131922. https:\/\/doi.org\/10.1080\/14656566.2024.2409322","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"11574_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12916-025-04014-0","volume":"23","author":"S Naeem","year":"2025","unstructured":"Naeem S, Wang F, Mubarak R, Shen H, Li X, Mommers I, Hussain SR, Malik SS, Yu C, Hak E, Xu X, Fawad M, Mubarik S (2025) Mapping the Global distribution, risk factors, and temporal trends of COPD incidence and mortality (1990\u20132021): ecological analysis. BMC Med 23(1):210. https:\/\/doi.org\/10.1186\/s12916-025-04014-0","journal-title":"BMC Med"},{"key":"11574_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1429946","volume":"15","author":"H Han","year":"2024","unstructured":"Han H, Meister M, Peng G, Yuan Y, Qiao J, Yang JJ, Liu ZR, Ji X (2024) Inhalation of nicotine-containing electronic cigarette vapor exacerbates the features of COPD by inducing ferroptosis in \u03b2ENaC-overexpressing mice. Front Immunol 15:1429946. https:\/\/doi.org\/10.3389\/fimmu.2024.1429946","journal-title":"Front Immunol"},{"issue":"3","key":"11574_CR6","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12608","volume":"25","author":"R Mo","year":"2022","unstructured":"Mo R, Zhang J, Chen Y, Ding Y (2022) Nicotine promotes chronic obstructive pulmonary disease via inducing pyroptosis activation in bronchial epithelial cells. Mol Med Rep 25(3):92. https:\/\/doi.org\/10.3892\/mmr.2022.12608","journal-title":"Mol Med Rep"},{"issue":"1","key":"11574_CR7","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.4102\/phcfm.v16i1.4756","volume":"16","author":"B Heran","year":"2024","unstructured":"Heran B, Perry TL, Bassett K (2024) Minimising inhaled corticosteroids for COPD. Afr J Prim Health Care Fam Med 16(1):e1\u2013e3. https:\/\/doi.org\/10.4102\/phcfm.v16i1.4756","journal-title":"Afr J Prim Health Care Fam Med"},{"key":"11574_CR8","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.2147\/copd.s431829","volume":"18","author":"M Tur\u00e9gano-Yedro","year":"2023","unstructured":"Tur\u00e9gano-Yedro M, Trillo-Calvo E, Navarro IRF, Maya-Viejo JD, Gonz\u00e1lez Villaescusa C, Echave Sustaeta JM, Do\u00f1a E, Alc\u00e1zar Navarrete B (2023) Inhaler adherence in COPD: a crucial step towards the correct treatment. Int J Chron Obstruct Pulmon Dis 18:2887\u20132893. https:\/\/doi.org\/10.2147\/copd.s431829","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"Pt C","key":"11574_CR9","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.semcdb.2023.05.003","volume":"154","author":"S Ahmad","year":"2024","unstructured":"Ahmad S, Zhang XL, Ahmad A (2024) Epigenetic regulation of pulmonary inflammation. Semin Cell Dev Biol 154(Pt C):346\u2013354. https:\/\/doi.org\/10.1016\/j.semcdb.2023.05.003","journal-title":"Semin Cell Dev Biol"},{"issue":"18","key":"11574_CR10","doi-asserted-by":"publisher","first-page":"e00232","DOI":"10.1128\/mcb.00232-20","volume":"40","author":"M Singh","year":"2020","unstructured":"Singh M, Bacolla A, Chaudhary S, Hunt CR, Pandita S, Chauhan R, Gupta A, Tainer JA, Pandita TK (2020) Histone acetyltransferase MOF orchestrates outcomes at the crossroad of oncogenesis, DNA damage response, proliferation, and stem cell development. Mol Cell Biol 40(18):e00232-00220. https:\/\/doi.org\/10.1128\/mcb.00232-20","journal-title":"Mol Cell Biol"},{"key":"11574_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.mad.2016.03.012","volume":"161","author":"K Mujoo","year":"2017","unstructured":"Mujoo K, Hunt CR, Horikoshi N, Pandita TK (2017) A multifaceted role for MOF histone modifying factor in genome maintenance. Mech Ageing Dev 161:177\u2013180. https:\/\/doi.org\/10.1016\/j.mad.2016.03.012","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"11574_CR12","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/jb\/mvad022","volume":"173","author":"S Srivastava","year":"2023","unstructured":"Srivastava S, Kumar S, Bhatt R, Ramachandran R, Trivedi AK, Kundu TK (2023) Lysine acetyltransferases (KATs) in disguise: diseases implications. J Biochem 173(6):417\u2013433. https:\/\/doi.org\/10.1093\/jb\/mvad022","journal-title":"J Biochem"},{"issue":"7","key":"11574_CR13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.7150\/ijbs.17260","volume":"13","author":"J Zhong","year":"2017","unstructured":"Zhong J, Ji L, Chen H, Li X, Zhang J, Wang X, Wu W, Xu Y, Huang F, Cai W, Sun ZS (2017) Acetylation of hMOF modulates H4K16ac to regulate DNA repair genes in response to oxidative stress. Int J Biol Sci 13(7):923\u2013934. https:\/\/doi.org\/10.7150\/ijbs.17260","journal-title":"Int J Biol Sci"},{"key":"11574_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2022.153251","volume":"477","author":"D Li","year":"2022","unstructured":"Li D, Shen C, Liu L, Hu J, Qin J, Dai L, Gao L, Cheng M, Wang D, Bao R, Wang B (2022) PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1\/Parkin-mediated mitophagy. Toxicology 477:153251. https:\/\/doi.org\/10.1016\/j.tox.2022.153251","journal-title":"Toxicology"},{"key":"11574_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.freeradbiomed.2024.08.036","volume":"224","author":"Y Wei","year":"2024","unstructured":"Wei Y, Li Q, He K, Liao G, Cheng L, Li M, He Z (2024) Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 \/ PINK 1-Parkin \/ EMT. Free Radic Biol Med 224:447\u2013456. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.08.036","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"11574_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20679-y","volume":"12","author":"GE Choi","year":"2021","unstructured":"Choi GE, Lee HJ, Chae CW, Cho JH, Jung YH, Kim JS, Kim SY, Lim JR, Han HJ (2021) BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun 12(1):487. https:\/\/doi.org\/10.1038\/s41467-020-20679-y","journal-title":"Nat Commun"},{"issue":"10","key":"11574_CR17","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.molcel.2023.04.021","volume":"83","author":"TN Nguyen","year":"2023","unstructured":"Nguyen TN, Sawa-Makarska J, Khuu G, Lam WK, Adriaenssens E, Fracchiolla D, Shoebridge S, Bernklau D, Padman BS, Skulsuppaisarn M, Lindblom RSJ, Martens S, Lazarou M (2023) Unconventional initiation of PINK1\/Parkin mitophagy by Optineurin. Mol Cell 83(10):1693-1709e.e1699. https:\/\/doi.org\/10.1016\/j.molcel.2023.04.021","journal-title":"Mol Cell"},{"key":"11574_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1236651","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu J, Wang J, Xiong A, Zhang L, Zhang Y, Liu Y, Xiong Y, Li G, He X (2023) Mitochondrial quality control in lung diseases: current research and future directions. Front Physiol 14:1236651. https:\/\/doi.org\/10.3389\/fphys.2023.1236651","journal-title":"Front Physiol"},{"issue":"12","key":"11574_CR19","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","volume":"5","author":"A Picca","year":"2023","unstructured":"Picca A, Faitg J, Auwerx J, Ferrucci L, D\u2019Amico D (2023) Mitophagy in human health, ageing and disease. Nat Metab 5(12):2047\u20132061. https:\/\/doi.org\/10.1038\/s42255-023-00930-8","journal-title":"Nat Metab"},{"issue":"1","key":"11574_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-01009-x","volume":"118","author":"AS Titus","year":"2023","unstructured":"Titus AS, Sung EA, Zablocki D, Sadoshima J (2023) Mitophagy for cardioprotection. Basic Res Cardiol 118(1):42. https:\/\/doi.org\/10.1007\/s00395-023-01009-x","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"11574_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01503-7","volume":"8","author":"S Wang","year":"2023","unstructured":"Wang S, Long H, Hou L, Feng B, Ma Z, Wu Y, Zeng Y, Cai J, Zhang DW, Zhao G (2023) The mitophagy pathway and its implications in human diseases. Signal Transduct Target Ther 8(1):304. https:\/\/doi.org\/10.1038\/s41392-023-01503-7","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"11574_CR22","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1080\/15548627.2018.1532259","volume":"15","author":"J Araya","year":"2019","unstructured":"Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K (2019) PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy 15(3):510\u2013526. https:\/\/doi.org\/10.1080\/15548627.2018.1532259","journal-title":"Autophagy"},{"key":"11574_CR23","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.2147\/copd.s130168","volume":"12","author":"Y Jiang","year":"2017","unstructured":"Jiang Y, Wang X, Hu D (2017) Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 12:1153\u20131162. https:\/\/doi.org\/10.2147\/copd.s130168","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"1","key":"11574_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-04066-8","volume":"15","author":"T Jin","year":"2024","unstructured":"Jin T, Liu X, Li G, Sun S, Xie L (2024) Intravenous injection of BMSCs modulate tsRNA expression and ameliorate lung remodeling in COPD mice. Stem Cell Res Ther 15(1):450. https:\/\/doi.org\/10.1186\/s13287-024-04066-8","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"11574_CR25","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/s2213-2600(21)00511-7","volume":"10","author":"D Adeloye","year":"2022","unstructured":"Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I (2022) Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med 10(5):447\u2013458. https:\/\/doi.org\/10.1016\/s2213-2600(21)00511-7","journal-title":"Lancet Respir Med"},{"issue":"5","key":"11574_CR26","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02469-2022","volume":"61","author":"DD Sin","year":"2023","unstructured":"Sin DD, Doiron D, Agusti A, Anzueto A, Barnes PJ, Celli BR, Criner GJ, Halpin D, Han MK, Martinez FJ, de Montes Oca M, Papi A, Pavord I, Roche N, Singh D, Stockley R, Lopez Varlera MV, Wedzicha J, Vogelmeier C, Bourbeau J (2023) Air pollution and COPD: GOLD 2023 committee report. Eur Respir J 61(5):2202469. https:\/\/doi.org\/10.1183\/13993003.02469-2022","journal-title":"Eur Respir J"},{"key":"11574_CR27","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0028-2022","author":"YS Fu","year":"2022","unstructured":"Fu YS, Kang N, Yu Y, Mi Y, Guo J, Wu J, Weng CF (2022) Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD. Eur Respir Rev. https:\/\/doi.org\/10.1183\/16000617.0028-2022","journal-title":"Eur Respir Rev"},{"issue":"5","key":"11574_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s2213-2600(21)00506-3","volume":"10","author":"IA Yang","year":"2022","unstructured":"Yang IA, Jenkins CR, Salvi SS (2022) Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respir Med 10(5):497\u2013511. https:\/\/doi.org\/10.1016\/s2213-2600(21)00506-3","journal-title":"Lancet Respir Med"},{"issue":"6","key":"11574_CR29","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1517\/17460441.2014.913020","volume":"9","author":"AC Schamberger","year":"2014","unstructured":"Schamberger AC, Mise N, Meiners S, Eickelberg O (2014) Epigenetic mechanisms in COPD: implications for pathogenesis and drug discovery. Expert Opin Drug Discov 9(6):609\u2013628. https:\/\/doi.org\/10.1517\/17460441.2014.913020","journal-title":"Expert Opin Drug Discov"},{"issue":"2","key":"11574_CR30","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y, Li Z, Zhang S, Zhang T, Liu Y, Zhang L (2023) Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13(2):736\u2013766. https:\/\/doi.org\/10.7150\/thno.79876","journal-title":"Theranostics"},{"issue":"1","key":"11574_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-97","volume":"14","author":"RF Hoffmann","year":"2013","unstructured":"Hoffmann RF, Zarrintan S, Brandenburg SM, Kol A, de Bruin HG, Jafari S, Dijk F, Kalicharan D, Kelders M, Gosker HR, Ten Hacken NH, van der Want JJ, van Oosterhout AJ, Heijink IH (2013) Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. Respir Res 14(1):97. https:\/\/doi.org\/10.1186\/1465-9921-14-97","journal-title":"Respir Res"},{"issue":"11","key":"11574_CR32","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.4161\/auto.26915","volume":"9","author":"M Campanella","year":"2014","unstructured":"Campanella M, Klionsky DJ (2014) Keeping the engine clean. Autophagy 9(11):1647\u20131647. https:\/\/doi.org\/10.4161\/auto.26915","journal-title":"Autophagy"},{"issue":"9","key":"11574_CR33","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1172\/jci74985","volume":"124","author":"K Mizumura","year":"2014","unstructured":"Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AMK (2014) Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest 124(9):3987\u20134003. https:\/\/doi.org\/10.1172\/jci74985","journal-title":"J Clin Invest"},{"key":"11574_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102587","volume":"59","author":"X Fan","year":"2023","unstructured":"Fan X, Dong T, Yan K, Ci X, Peng L (2023) PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4\/Nrf2 redox imbalance-mediated mitophagy. Redox Biol 59:102587. https:\/\/doi.org\/10.1016\/j.redox.2022.102587","journal-title":"Redox Biol"},{"issue":"1","key":"11574_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-018-0077-6","volume":"38","author":"K Tsubouchi","year":"2018","unstructured":"Tsubouchi K, Araya J, Kuwano K (2018) PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses. Inflamm Regen 38(1):18. https:\/\/doi.org\/10.1186\/s41232-018-0077-6","journal-title":"Inflamm Regen"},{"key":"11574_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.brainresbull.2022.03.013","volume":"184","author":"D Lingling","year":"2022","unstructured":"Lingling D, Miaomiao Q, Yili L, Hongyun H, Yihao D (2022) Attenuation of histone H4 lysine 16 acetylation (H4K16ac) elicits a neuroprotection against ischemic stroke by alleviating the autophagic\/lysosomal dysfunction in neurons at the penumbra. Brain Res Bull 184:24\u201333. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.03.013","journal-title":"Brain Res Bull"},{"issue":"10","key":"11574_CR37","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.4161\/auto.25803","volume":"9","author":"J F\u00fcllgrabe","year":"2013","unstructured":"F\u00fcllgrabe J, Klionsky DJ, Joseph B (2013) Histone post-translational modifications regulate autophagy flux and outcome. Autophagy 9(10):1621\u20131623. https:\/\/doi.org\/10.4161\/auto.25803","journal-title":"Autophagy"},{"issue":"3","key":"11574_CR38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.taap.2009.08.027","volume":"241","author":"WJ Jo","year":"2009","unstructured":"Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame A, Smith MT, Vulpe CD, Zhang L (2009) Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol 241(3):294\u2013302. https:\/\/doi.org\/10.1016\/j.taap.2009.08.027","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"11574_CR39","doi-asserted-by":"publisher","first-page":"530","DOI":"10.7150\/thno.62760","volume":"12","author":"X Zhang","year":"2022","unstructured":"Zhang X, Liu H, Zhou JQ, Krick S, Barnes JW, Thannickal VJ, Sanders YY (2022) Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice. Theranostics 12(2):530\u2013541. https:\/\/doi.org\/10.7150\/thno.62760","journal-title":"Theranostics"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11574-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:42:11Z","timestamp":1772631731000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11574-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11574"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11574-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal study protocol was approved by the Ethics Committee of Hainan General Hospital (NO. Med-Eth-Re[2023]45). All animal procedures were conducted in accordance with the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}}],"article-number":"462"}}