{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:29:31Z","timestamp":1771662571065,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYL-2022-12350"],"award-info":[{"award-number":["TYL-2022-12350"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11576-6","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:53:54Z","timestamp":1771660434000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a novel long non-coding RNA (LOC105377284) regulating PPAR\u03b3-dependent adipogenesis"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1336-1250","authenticated-orcid":false,"given":"Merve","family":"Basar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-5689","authenticated-orcid":false,"given":"Muge Gulcihan","family":"Onal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-7892","authenticated-orcid":false,"given":"Armagan","family":"Akkus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-8250","authenticated-orcid":false,"given":"Canan Sehit","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-6744","authenticated-orcid":false,"given":"Fahri","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"11576_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/endrev\/bnaa004","volume":"41","author":"M Bl\u00fcher","year":"2020","unstructured":"Bl\u00fcher M (2020) MetabolicallyHealthyObesity. Endocr Rev 41:1\u201316. https:\/\/doi.org\/10.1210\/endrev\/bnaa004","journal-title":"Endocr Rev"},{"key":"11576_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/dom.14290","volume":"23","author":"S Sarma","year":"2021","unstructured":"Sarma S, Sockalingam S, Dash S (2021) Obesity as a multisystemdisease: trends in obesityrates and obesity-relatedcomplications. Diabetes Obes Metab 23:3\u201316. https:\/\/doi.org\/10.1111\/dom.14290","journal-title":"Diabetes Obes Metab"},{"key":"11576_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ajhb.22245","volume":"24","author":"J Prakash","year":"2012","unstructured":"Prakash J, Srivastava N, Awasthi S, Agarwal C, Natu S, Rajpal N, Mittal B (2012) Association of PPAR-\u03b3 gene polymorphismswithobesity and obesity\u2010associatedphenotypes in northindianpopulation. Am J Hum Biol 24:454\u2013459. https:\/\/doi.org\/10.1002\/ajhb.22245","journal-title":"Am J Hum Biol"},{"key":"11576_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900482","volume":"65","author":"S Curley","year":"2021","unstructured":"Curley S, Gall J, Byrne R, Yvan-Charvet L, McGillicuddy FC (2021) MetabolicInflammation in Obesity\u2014At the CrossroadsbetweenFattyAcid and CholesterolMetabolism. Mol Nutr Food Res 65:e1900482. https:\/\/doi.org\/10.1002\/mnfr.201900482","journal-title":"Mol Nutr Food Res"},{"key":"11576_CR5","first-page":"185","volume":"10","author":"E G\u00fclcan","year":"2006","unstructured":"G\u00fclcan E, \u00d6zkan A (2006) Obezite. Journal of Science and Technology of Dumlup\u0131nar University 10:185\u2013194","journal-title":"Journal of Science and Technology of Dumlup\u0131nar University"},{"key":"11576_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","volume":"92","author":"YC Chooi","year":"2019","unstructured":"Chooi YC, Ding C, Magkos F (2019) The epidemiology of obesity. Metabolism 92:6\u201310. https:\/\/doi.org\/10.1016\/j.metabol.2018.09.005","journal-title":"Metabolism"},{"key":"11576_CR7","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s11745-017-4291-9","volume":"52","author":"SS Hammad","year":"2017","unstructured":"Hammad SS, Jones PJ (2017) DietaryFattyAcidCompositionModulatesObesity and InteractswithObesity-RelatedGenes. Lipids 52:803\u2013822. https:\/\/doi.org\/10.1007\/s11745-017-4291-9","journal-title":"Lipids"},{"key":"11576_CR8","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1080\/07391102.2020.1835724","volume":"40","author":"A Stalin","year":"2022","unstructured":"Stalin A, Lin D, Josephine Princy J, Feng Y, Xiang H, Ignacimuthu S, Chen Y (2022) Computationalanalysis of singlenucleotidepolymorphisms (SNPs) in PPAR gamma associatedwithobesity, diabetes and cancer. J Biomol Struct Dyn 40:1843\u20131857. https:\/\/doi.org\/10.1080\/07391102.2020.1835724","journal-title":"J Biomol Struct Dyn"},{"key":"11576_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrendo.2016.135","volume":"13","author":"B Gross","year":"2017","unstructured":"Gross B, Pawlak M, Lefebvre P, Staels B (2017) PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. Nat Rev Endocrinol 13:36\u201349. https:\/\/doi.org\/10.1038\/nrendo.2016.135","journal-title":"Nat Rev Endocrinol"},{"key":"11576_CR10","doi-asserted-by":"publisher","first-page":"7488","DOI":"10.3390\/ijms23137488","volume":"23","author":"P Zhang","year":"2022","unstructured":"Zhang P, Wu S, He Y, Li X, Zhu Y, Lin X, Chen L, Zhao Y, Niu L, Zhang S, Li X, Zhu L, Shen L (2022) LncRNA-mediatedadipogenesis in differentadipocytes. Int J Mol Sci 23:7488. https:\/\/doi.org\/10.3390\/ijms23137488","journal-title":"Int J Mol Sci"},{"key":"11576_CR11","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41419-021-03821-6","volume":"12","author":"S-H Wang","year":"2021","unstructured":"Wang S-H, Zhu X-L, Wang F, Chen S-X, Chen Z-T, Qiu Q, Liu W-H, Wu M-X, Deng B-Q, Xie Y, Mai J-T, Yang Y, Wang J-F, Zhang H-F, Chen Y-X (2021) LncRNA H19 governsmitophagy and restoresmitochondrialrespiration in the heartthrough Pink1\/Parkinsignalingduringobesity. Cell Death Dis 12:557. https:\/\/doi.org\/10.1038\/s41419-021-03821-6","journal-title":"Cell Death Dis"},{"key":"11576_CR12","doi-asserted-by":"publisher","first-page":"8337","DOI":"10.3390\/ijms21218337","volume":"21","author":"K-H Lee","year":"2020","unstructured":"Lee K-H, Hwang H-J, Cho J-Y (2020) Longnon-coding RNA associatedwithcholesterolhomeostasis and itsinvolvement in metabolicdiseases. Int J Mol Sci 21:8337. https:\/\/doi.org\/10.3390\/ijms21218337","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11576_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40168-017-0258-6","volume":"5","author":"L Xiao","year":"2017","unstructured":"Xiao L, Sonne SB, Feng Q, Chen N, Xia Z, Li X, Fang Z, Zhang D, Fj\u00e6re E, Midtb\u00f8 LK, Derrien M, Hugenholtz F, Tang L, Li J, Zhang J, Liu C, Hao Q, Vogel UB, Mortensen A, Kleerebezem M, Licht TR, Yang H, Wang J, Li Y, Arumugam M, Wang J, Madsen L, Kristiansen K (2017) High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice. Microbiome. https:\/\/doi.org\/10.1186\/s40168-017-0258-6","journal-title":"Microbiome"},{"key":"11576_CR14","doi-asserted-by":"publisher","unstructured":"Lee CY (2023) Effects of dietary vitamins on obesity-related metabolic parameters. Journal of nutritional science, 12, e47. https:\/\/doi.org\/10.1017\/jns.2023.30Lee","DOI":"10.1017\/jns.2023.30Lee"},{"key":"11576_CR15","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1007\/s00394-021-02769-9","volume":"61","author":"S Chen","year":"2022","unstructured":"Chen S, Yang M, Wang R, Fan X, Tang T, Li P, Zhou X, Qi K (2022) Suppression of high-fat-diet-inducedobesity in micebydietaryfolicacidsupplementation is linked to changes in gut microbiota. Eur J Nutr 61:2015\u20132031. https:\/\/doi.org\/10.1007\/s00394-021-02769-9","journal-title":"Eur J Nutr"},{"key":"11576_CR16","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/ijc.32236","volume":"145","author":"L Shen","year":"2019","unstructured":"Shen L, Han J, Wang H, Meng Q, Chen L, Liu Y, Feng Y, Wu G (2019) Cachexia-relatedlongnoncoding RNA, CAAlnc1, suppressesadipogenesisbyblocking the binding of HuR to adipogenictranscriptionfactormrnas. Int J Cancer 145:1809\u20131821. https:\/\/doi.org\/10.1002\/ijc.32236","journal-title":"Int J Cancer"},{"key":"11576_CR17","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3892\/ijo.2018.4418","volume":"53","author":"X Li","year":"2018","unstructured":"Li X, Zhao Q, Qi J, Wang W, Zhang D, Li Z, Qin C (2018) LncRNAFtxpromotesaerobicglycolysis and tumorprogressionthrough the PPAR\u03b3pathway in hepatocellularcarcinoma. Int J Oncol 53:551\u2013566. https:\/\/doi.org\/10.3892\/ijo.2018.4418","journal-title":"Int J Oncol"},{"key":"11576_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.203","author":"LJ Aronne","year":"2002","unstructured":"Aronne LJ (2002) Classification of obesity and assessment of obesity-RelatedHealthRisks. ObesRes10. https:\/\/doi.org\/10.1038\/oby.2002.203","journal-title":"ObesRes10"},{"key":"11576_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.02126","author":"F Favieri","year":"2019","unstructured":"Favieri F, Forte G, Casagrande M (2019) The executiveFunctions in overweight and obesity: a systematicReview of neuropsychological cross-sectional and longitudinalStudies. Front Psychol. https:\/\/doi.org\/10.3389\/fpsyg.2019.02126","journal-title":"Front Psychol"},{"key":"11576_CR20","doi-asserted-by":"publisher","first-page":"8870","DOI":"10.3390\/ijms24108870","volume":"24","author":"WJ Khalil","year":"2023","unstructured":"Khalil WJ, Akeblersane M, Khan AS, Moin ASM, Butler AE (2023) Environmentalpollution and the risk of developingmetabolicdisorders: obesity and diabetes. Int J Mol Sci 24:8870. https:\/\/doi.org\/10.3390\/ijms24108870","journal-title":"Int J Mol Sci"},{"key":"11576_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00414","author":"Y Sun","year":"2019","unstructured":"Sun Y, Sun M, Liu B, Du Y, Rong S, Xu G, Snetselaar LG, Bao W (2019) InverseAssociationBetween serum vitamin B12 concentration and obesityAmongAdults in the United States. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2019.00414","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11576_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/ejh.13560","volume":"106","author":"JC Purdy","year":"2021","unstructured":"Purdy JC, Shatzel JJ (2021) The hematologicconsequences of obesity. Eur J Haematol 106:306\u2013319. https:\/\/doi.org\/10.1111\/ejh.13560","journal-title":"Eur J Haematol"},{"key":"11576_CR23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/obr.12239","volume":"16","author":"M Pereira-Santos","year":"2015","unstructured":"Pereira-Santos M, Costa PRF, Assis AMO, Santos CAST, Santos DB (2015) Obesity and vitamin\u2009<\u2009scp>ddeficiency: a systematicreview and meta\u2010analysis. Obes Rev 16:341\u2013349. https:\/\/doi.org\/10.1111\/obr.12239","journal-title":"Obes Rev"},{"key":"11576_CR24","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/ijo.2016.189","volume":"41","author":"J Chen","year":"2017","unstructured":"Chen J, Liu Y, Lu S, Yin L, Zong C, Cui S, Qin D, Yang Y, Guan Q, Li X, Wang X (2017) The role and possiblemechanism of LncRNA U90926 in modulating 3T3-L1 preadipocytedifferentiation. Int J Obes 41:299\u2013308. https:\/\/doi.org\/10.1038\/ijo.2016.189","journal-title":"Int J Obes"},{"key":"11576_CR25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/JLB.5MR0120-377R","volume":"108","author":"GN Calco","year":"2020","unstructured":"Calco GN, Fryer AD, Nie Z (2020) Unraveling the connectionbetweeneosinophils and obesity. J Leukoc Biol 108:123\u2013128. https:\/\/doi.org\/10.1002\/JLB.5MR0120-377R","journal-title":"J Leukoc Biol"},{"key":"11576_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/mnfr.201500272","volume":"60","author":"V Apostolopoulos","year":"2016","unstructured":"Apostolopoulos V, de Courten MPJ, Stojanovska L, Blatch GL, Tangalakis K, de Courten B (2016) The compleximmunological and inflammatory network of adiposetissue in obesity. Mol Nutr Food Res 60:43\u201357. https:\/\/doi.org\/10.1002\/mnfr.201500272","journal-title":"Mol Nutr Food Res"},{"key":"11576_CR27","doi-asserted-by":"publisher","unstructured":"Zhang B, Xu S, Liu J, Xie Y, Xiaobo S (2021) Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases. Frontiers in physiology, 12, 691824. https:\/\/doi.org\/10.3389\/fphys.2021.691824","DOI":"10.3389\/fphys.2021.691824"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11576-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11576-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11576-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:53:55Z","timestamp":1771660435000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11576-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11576"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11576-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Erciyes University Clinical Research Ethics Committee (Approval No: 588, Date: September 14, 2022). Written informed consent was obtained from all participants prior to inclusion.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent to the publication of this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"410"}}