{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:52:52Z","timestamp":1792630372784,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11590-8","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:21:49Z","timestamp":1771928509000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhanced antibiofilm and gene-suppressive effects of cinnamon nanoemulsion against multidrug-resistant Enterococcus faecalis"],"prefix":"10.1007","volume":"53","author":[{"given":"Pourya","family":"Gholizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhaneh","family":"Rahimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Mohammadi-Ghalehbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohesn","family":"Arzanlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Soozangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Feizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"2","key":"11590_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41579-018-0107-z","volume":"17","author":"J-H Ch\u2019ng","year":"2019","unstructured":"Ch\u2019ng J-H, Chong KK, Lam LN, Wong JJ, Kline KA (2019) Biofilm-associated infection by enterococci. Nat Rev Microbiol 17(2):82\u201394","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"11590_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/10820132211013273","volume":"28","author":"M Somrani","year":"2022","unstructured":"Somrani M, Debbabi H, Palop A (2022) Antibacterial and antibiofilm activity of essential oil of clove against Listeria monocytogenes and Salmonella enteritidis. Food Sci Technol Int 28(4):331\u2013339","journal-title":"Food Sci Technol Int"},{"issue":"6","key":"11590_CR3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00284-022-02858-w","volume":"79","author":"M Namaki Kheljan","year":"2022","unstructured":"Namaki Kheljan M, Teymorpour R, Peeri Doghaheh H, Arzanlou M (2022) Antimicrobial biocides susceptibility and tolerance-associated genes in enterococcus faecalis and enterococcus faecium isolates collected from human and environmental sources. Curr Microbiol 79(6):170. https:\/\/doi.org\/10.1007\/s00284-022-02858-w","journal-title":"Curr Microbiol"},{"issue":"8","key":"11590_CR4","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.3390\/ijms18081748","volume":"18","author":"P Neelakantan","year":"2017","unstructured":"Neelakantan P, Romero M, Vera J, Daood U, Khan AU, Yan A, Cheung GSP (2017) biofilms in endodontics-current status and future directions. Int J Mol Sci 18(8):1748. https:\/\/doi.org\/10.3390\/ijms18081748","journal-title":"Int J Mol Sci"},{"issue":"5","key":"11590_CR5","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/iej.13050","volume":"52","author":"R Swimberghe","year":"2019","unstructured":"Swimberghe R, Coenye T, De Moor R, Meire M (2019) Biofilm model systems for root canal disinfection: a literature review. Int Endod J 52(5):604\u2013628","journal-title":"Int Endod J"},{"issue":"1","key":"11590_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1601-1546.2012.00277.x","volume":"22","author":"D Dufour","year":"2010","unstructured":"Dufour D, Leung V, L\u00e9vesque CM (2010) Bacterial biofilm: structure, function, and antimicrobial resistance. Endodontic Top 22(1):2\u201316","journal-title":"Endodontic Top"},{"key":"11590_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13756-019-0533-3","volume":"8","author":"D Sharma","year":"2019","unstructured":"Sharma D, Misba L, Khan AU (2019) Antibiotics versus biofilm: an emerging battleground in microbial communities. Antimicrob Resist Infect Control 8:1\u201310","journal-title":"Antimicrob Resist Infect Control"},{"issue":"1","key":"11590_CR8","doi-asserted-by":"publisher","first-page":"5190603","DOI":"10.1155\/2020\/5190603","volume":"2020","author":"B Alizadeh Behbahani","year":"2020","unstructured":"Alizadeh Behbahani B, Falah F, Lavi Arab F, Vasiee M, Tabatabaee Yazdi F (2020) Chemical composition and antioxidant, antimicrobial, and antiproliferative activities of Cinnamomum zeylanicum bark essential oil. Evidence-Based Complement Altern Med 2020(1):5190603","journal-title":"Evidence-Based Complement Altern Med"},{"issue":"1","key":"11590_CR9","doi-asserted-by":"publisher","first-page":"3012462","DOI":"10.1155\/2016\/3012462","volume":"2016","author":"MK Swamy","year":"2016","unstructured":"Swamy MK, Akhtar MS, Sinniah UR (2016) Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evidence-Based Complement Altern Med 2016(1):3012462","journal-title":"Evidence-Based Complement Altern Med"},{"key":"11590_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ibiod.2014.12.007","volume":"98","author":"N Zandi-Sohani","year":"2015","unstructured":"Zandi-Sohani N, Ramezani L (2015) Evaluation of five essential oils as botanical acaricides against the strawberry spider mite Tetranychus turkestani Ugarov and Nikolskii. Int Biodeterior Biodegrad 98:101\u2013106","journal-title":"Int Biodeterior Biodegrad"},{"key":"11590_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.indcrop.2016.12.006","volume":"97","author":"R de Ribeiro-Santos","year":"2017","unstructured":"Ribeiro-Santos R, Andrade M, de Melo NR, dos Santos FR, de Ara\u00fajo Neves I, de Carvalho MG Sanches-Silva A (2017) Biological activities and major components determination in essential oils intended for a biodegradable food packaging. Ind Crops Prod, 97, 201\u2013210. https:\/\/doi.org\/10.1016\/j.indcrop.2016.12.006","journal-title":"Ind Crops Prod"},{"key":"11590_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cofs.2015.07.003","volume":"5","author":"C Dima","year":"2015","unstructured":"Dima C, Dima S (2015) Essential oils in foods: extraction, stabilization, and toxicity. Curr Opin Food Sci 5:29\u201335","journal-title":"Curr Opin Food Sci"},{"issue":"2","key":"11590_CR13","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10311-020-01142-2","volume":"19","author":"TN Barradas","year":"2021","unstructured":"Barradas TN, de Holanda e Silva KG (2021) Nanoemulsions of essential oils to improve solubility, stability and permeability: a review. Environ Chem Lett 19(2):1153\u20131171","journal-title":"Environ Chem Lett"},{"key":"11590_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-10-9","volume":"10","author":"RM Darwish","year":"2010","unstructured":"Darwish RM, Aburjai TA (2010) Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complement Altern Med 10:1\u20138","journal-title":"BMC Complement Altern Med"},{"issue":"10","key":"11590_CR15","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.1128\/AEM.70.10.5750-5755.2004","volume":"70","author":"AO Gill","year":"2004","unstructured":"Gill AO, Holley RA (2004) Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei. Appl Environ Microbiol 70(10):5750\u20135755","journal-title":"Appl Environ Microbiol"},{"key":"11590_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2012.00012","volume":"3","author":"M Hyldgaard","year":"2012","unstructured":"Hyldgaard M, Mygind T, Meyer RL (2012) Essential oils in food preservation: mode of action, synergies, and interactions with food matrix component. Front Microbiol 3:1\u201324. https:\/\/doi.org\/10.3389\/fmicb.2012.00012","journal-title":"Front Microbiol"},{"issue":"1","key":"11590_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12941-021-00455-6","volume":"20","author":"P Gholizadeh","year":"2021","unstructured":"Gholizadeh P, Aghazadeh M, Ghotaslou R, Rezaee MA, Pirzadeh T, Cui L, Watanabe S, Feizi H, Kadkhoda H, Kafil HS (2021) Role of CRISPR-Cas system on antibiotic resistance patterns of Enterococcus faecalis. Ann Clin Microbiol Antimicrob 20(1):49. https:\/\/doi.org\/10.1186\/s12941-021-00455-6","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"1","key":"11590_CR18","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/21505594.2020.1809329","volume":"11","author":"P Gholizadeh","year":"2020","unstructured":"Gholizadeh P, Mohammad A, Reza G, Mohammad AR, Tahereh P, \u015e\u00fckran K, Khudaverdi G, Mehdi Y, Kafil HS (2020) CRISPR-cas system in the acquisition of virulence genes in dental-root canal and hospital-acquired isolates of Enterococcus faecalis. Virulence 11(1):1257\u20131267. https:\/\/doi.org\/10.1080\/21505594.2020.1809329","journal-title":"Virulence"},{"issue":"1","key":"11590_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.13005\/ojc\/300105","volume":"30","author":"Y Wong","year":"2014","unstructured":"Wong Y, Ahmad-Mudzaqqir M, Wan-Nurdiyana W (2014) Extraction of essential oil from cinnamon (Cinnamomum zeylanicum). Orient J Chem 30(1):37","journal-title":"Orient J Chem"},{"key":"11590_CR20","doi-asserted-by":"publisher","first-page":"989667","DOI":"10.3389\/fmicb.2022.989667","volume":"13","author":"T Gani\u0107","year":"2022","unstructured":"Gani\u0107 T, Vuleti\u0107 S, Nikoli\u0107 B, Stevanovi\u0107 M, Kuzmanovi\u0107 M, Keki\u0107 D, \u0110urovi\u0107 S, Cvetkovi\u0107 S, Miti\u0107-\u0106ulafi\u0107 D (2022) Cinnamon essential oil and its emulsion as efficient antibiofilm agents to combat Acinetobacter baumannii. Front Microbiol 13:989667","journal-title":"Front Microbiol"},{"key":"11590_CR21","unstructured":"Kristich CJ, Rice LB, Arias CA (2014) Enterococcal infection\u2014treatment and antibiotic resistance"},{"issue":"2","key":"11590_CR22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.joen.2005.10.049","volume":"32","author":"CH Stuart","year":"2006","unstructured":"Stuart CH, Schwartz SA, Beeson TJ, Owatz CB (2006) Enterococcus faecalis: its role in root canal treatment failure and current concepts in retreatment. J Endod 32(2):93\u201398. https:\/\/doi.org\/10.1016\/j.joen.2005.10.049","journal-title":"J Endod"},{"key":"11590_CR23","first-page":"339","volume-title":"Cinnamon (Cinnamomum zeylanicum) essential oils. InEssential oils in food preservation, flavor and safety","author":"GA Cardoso-Ugarte","year":"2016","unstructured":"Cardoso-Ugarte GA, L\u00f3pez-Malo A, Sosa-Morales ME (2016) Cinnamon (Cinnamomum zeylanicum) essential oils. In Essential oils in food preservation, flavor and safety 2016 Jan 1 (pp. 339\u2013347). Academic"},{"key":"11590_CR24","doi-asserted-by":"publisher","first-page":"100013","DOI":"10.1016\/j.rechem.2019.100013","volume":"1","author":"AA Doyle","year":"2019","unstructured":"Doyle AA, Kr\u00e4mer T, Kavanagh K, Stephens JC, Cinnamaldehydes (2019) Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity. Results Chem 1:100013","journal-title":"Results Chem"},{"issue":"2","key":"11590_CR25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/jam.14794","volume":"130","author":"A Balasubramanian","year":"2021","unstructured":"Balasubramanian A, Vasudevan S, Shanmugam K, L\u00e9vesque C, Solomon A, Neelakantan P (2021) Combinatorial effects of trans-cinnamaldehyde with fluoride and chlorhexidine on Streptococcus mutans. J Appl Microbiol 130(2):382\u2013393","journal-title":"J Appl Microbiol"},{"issue":"2","key":"11590_CR26","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3390\/plants13020192","volume":"13","author":"N Ferrando","year":"2024","unstructured":"Ferrando N, Pino-Ot\u00edn MR, Ballestero D, Lorca G, Terrado EM, Langa E (2024) Enhancing commercial antibiotics with trans-cinnamaldehyde in Gram-positive and Gram-negative bacteria: An in vitro approach. Plants 13(2):192","journal-title":"Plants"},{"issue":"2","key":"11590_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1089\/fpd.2022.0073","volume":"20","author":"L Song","year":"2023","unstructured":"Song L, Yang H, Meng X, Su R, Cheng S, Wang H, Bai X, Guo D, L\u00fc X, Xia X (2023) Inhibitory effects of trans-cinnamaldehyde against Pseudomonas aeruginosa biofilm formation. Foodborne Pathog Dis 20(2):47\u201358","journal-title":"Foodborne Pathog Dis"},{"issue":"6","key":"11590_CR28","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1039\/C2SM06903B","volume":"8","author":"DJ McClements","year":"2012","unstructured":"McClements DJ (2012) Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8(6):1719\u20131729. https:\/\/doi.org\/10.1039\/C2SM06903B","journal-title":"Soft Matter"},{"issue":"6","key":"11590_CR29","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3390\/antibiotics10060702","volume":"10","author":"IA Ali","year":"2021","unstructured":"Ali IA, Matinlinna JP, L\u00e9vesque CM, Neelakantan P (2021) Trans-cinnamaldehyde attenuates Enterococcus faecalis virulence and inhibits biofilm formation. Antibiotics 10(6):702","journal-title":"Antibiotics"},{"issue":"11","key":"11590_CR30","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.3390\/pharmaceutics14112355","volume":"14","author":"M Hu","year":"2022","unstructured":"Hu M, Kalimuthu S, Zhang C, Ali IA, Neelakantan P (2022) Trans-cinnamaldehyde\u2013Biosurfactant complex as a potent agent against enterococcus faecalis biofilms. pharmaceutics 14(11):2355","journal-title":"Pharmaceutics"},{"key":"11590_CR31","doi-asserted-by":"publisher","first-page":"104482","DOI":"10.1016\/j.micpath.2020.104482","volume":"149","author":"IAA Ali","year":"2020","unstructured":"Ali IAA, Cheung BPK, Matinlinna J, L\u00e9vesque CM, Neelakantan P (2020) Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery. Microb Pathog 149:104482. https:\/\/doi.org\/10.1016\/j.micpath.2020.104482","journal-title":"Microb Pathog"},{"issue":"10","key":"11590_CR32","doi-asserted-by":"publisher","first-page":"5127","DOI":"10.1016\/j.psj.2020.06.067","volume":"99","author":"F Liu","year":"2020","unstructured":"Liu F, Jin P, Gong H, Sun Z, Du L, Wang D (2020) Antibacterial and antibiofilm activities of thyme oil against foodborne multiple antibiotics-resistant Enterococcus faecalis. Poult Sci 99(10):5127\u20135136","journal-title":"Poult Sci"},{"issue":"1","key":"11590_CR33","doi-asserted-by":"publisher","first-page":"5911","DOI":"10.1038\/s41598-021-85375-3","volume":"11","author":"Y-J Jeong","year":"2021","unstructured":"Jeong Y-J, Kim H-E, Han S-J, Choi J-S (2021) Antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion against multi-species oral biofilms. Sci Rep 11(1):5911","journal-title":"Sci Rep"},{"issue":"1","key":"11590_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/microorganisms11010002","volume":"11","author":"W Wang","year":"2022","unstructured":"Wang W, Chen Y-F, Wei Z-F, Jiang J-J, Peng J-Q, He Q-T, Xu W-Y, Liu H-M (2022) Microemulsion of cinnamon essential oil formulated with tea polyphenols, gallic acid, and tween 80: Antimicrobial properties, stability and mechanism of action. Microorganisms 11(1):2","journal-title":"Microorganisms"},{"key":"11590_CR35","doi-asserted-by":"publisher","unstructured":"Kaur G, Singh P, Sharma S (2021) Physical, morphological, and storage studies of cinnamon based nanoemulsions developed with Tween 80 and soy lecithin: A comparative study. J Food Meas Charact 15(3):2386\u20132398. https:\/\/doi.org\/10.1007\/s11694-021-00817-w","DOI":"10.1007\/s11694-021-00817-w"},{"issue":"7","key":"11590_CR36","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.joen.2016.03.015","volume":"42","author":"M Barbosa-Ribeiro","year":"2016","unstructured":"Barbosa-Ribeiro M, De-Jesus-Soares A, Zaia AA, Ferraz CC, Almeida JF, Gomes BP (2016) Antimicrobial susceptibility and characterization of virulence genes of enterococcus faecalis isolates from teeth with failure of the endodontic treatment. J Endod 42(7):1022\u20131028. https:\/\/doi.org\/10.1016\/j.joen.2016.03.015","journal-title":"J Endod"},{"issue":"12","key":"11590_CR37","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1007\/s13197-018-3394-5","volume":"55","author":"S Basak","year":"2018","unstructured":"Basak S, Guha P (2018) A review on antifungal activity and mode of action of essential oils and their delivery as nano-sized oil droplets in food system. J Food Sci Technol 55(12):4701\u20134710. https:\/\/doi.org\/10.1007\/s13197-018-3394-5","journal-title":"J Food Sci Technol"},{"issue":"2","key":"11590_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11051-025-06227-z","volume":"27","author":"M Moradialvand","year":"2025","unstructured":"Moradialvand M, Saniee P, McClements DJ, Rafati H (2025) Enhanced antimicrobial activity of Cinnamomum zeylanicum essential oil nanoemulsions against Helicobacter pylori: a microfluidic-based assessment. J Nanopart Res 27(2):27. https:\/\/doi.org\/10.1007\/s11051-025-06227-z","journal-title":"J Nanopart Res"},{"key":"11590_CR39","doi-asserted-by":"publisher","first-page":"989667","DOI":"10.3389\/fmicb.2022.989667","volume":"13","author":"T Gani\u0107","year":"2022","unstructured":"Gani\u0107 T, Vuleti\u0107 S, Nikoli\u0107 B, Stevanovi\u0107 M, Kuzmanovi\u0107 M, Keki\u0107 D, \u0110urovi\u0107 S, Cvetkovi\u0107 S, Miti\u0107-\u0106ulafi\u0107 D (2022) Cinnamon essential oil and its emulsion as efficient antibiofilm agents to combat Acinetobacter baumannii. Front Microbiol 13:989667. https:\/\/doi.org\/10.3389\/fmicb.2022.989667","journal-title":"Front Microbiol"},{"key":"11590_CR40","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.lwt.2016.08.046","volume":"775","author":"S Zhang","year":"2017","unstructured":"Zhang S, Zhang M, Fang Z, Liu Y (2017) Preparation and characterization of blended cloves\/cinnamon essential oil nanoemulsions. Lwt 775: 316\u2013322","journal-title":"Lwt"},{"key":"11590_CR41","doi-asserted-by":"publisher","first-page":"111450","DOI":"10.1016\/j.msec.2020.111450","volume":"119","author":"P Mishra","year":"2021","unstructured":"Mishra P, Gupta P, Pruthi V (2021) Cinnamaldehyde incorporated gellan\/PVA electrospun nanofibers for eradicating Candida biofilm. Mater Sci Engineering: C 119:111450. https:\/\/doi.org\/10.1016\/j.msec.2020.111450","journal-title":"Mater Sci Engineering: C"},{"issue":"7","key":"11590_CR42","doi-asserted-by":"publisher","first-page":"E15734072322707","DOI":"10.2174\/0115734072322707240902074426","volume":"21","author":"A Ali","year":"2025","unstructured":"Ali A, Ismayel SM, Samama M, Kumar A, Gupta P (2025) Pharmacological benefits of cinnamaldehyde: a comprehensive insight. Curr Bioact Compd 21(7):E15734072322707","journal-title":"Curr Bioact Compd"},{"issue":"9","key":"11590_CR43","doi-asserted-by":"publisher","first-page":"12201","DOI":"10.1021\/acsomega.8b01856","volume":"3","author":"P Gupta","year":"2018","unstructured":"Gupta P, Gupta S, Sharma M, Kumar N, Pruthi V, Poluri KM (2018) Effectiveness of phytoactive molecules on transcriptional expression, biofilm matrix, and cell wall components of candida glabrata and its clinical isolates. ACS Omega 3(9):12201\u201312214. https:\/\/doi.org\/10.1021\/acsomega.8b01856","journal-title":"ACS Omega"},{"issue":"5","key":"11590_CR44","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3390\/ijms18050960","volume":"18","author":"L Ali","year":"2017","unstructured":"Ali L, Goraya MU, Arafat Y, Ajmal M, Chen J-L, Yu D (2017) Molecular mechanism of quorum-sensing in enterococcus faecalis: its role in virulence and therapeutic approaches. Int J Mol Sci 18(5):960","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11590_CR45","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12879-024-09117-2","volume":"24","author":"M Ghazvinian","year":"2024","unstructured":"Ghazvinian M, Asgharzadeh Marghmalek S, Gholami M, Amir Gholami S, Amiri E, Goli HR (2024) Antimicrobial resistance patterns, virulence genes, and biofilm formation in enterococci strains collected from different sources. BMC Infect Dis 24(1):274","journal-title":"BMC Infect Dis"},{"issue":"1","key":"11590_CR46","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/1574-6968.12146","volume":"344","author":"ALV Cohen","year":"2013","unstructured":"Cohen ALV, Roh JH, Nallapareddy SR, H\u00f6\u00f6k M, Murray BE (2013) Expression of the collagen adhesin ace by Enterococcus faecalis strain OG1RF is not repressed by Ers but requires the Ers box. FEMS Microbiol Lett 344(1):18\u201324","journal-title":"FEMS Microbiol Lett"},{"issue":"9","key":"11590_CR47","doi-asserted-by":"publisher","first-page":"e1010829","DOI":"10.1371\/journal.ppat.1010829","volume":"18","author":"L Spiegelman","year":"2022","unstructured":"Spiegelman L, Bahn-Suh A, Monta\u00f1o ET, Zhang L, Hura GL, Patras KA, Kumar A, Tezcan FA, Nizet V, Tsutakawa SE et al (2022) Strengthening of enterococcal biofilms by Esp. PLoS Pathog 18(9):e1010829. https:\/\/doi.org\/10.1371\/journal.ppat.1010829","journal-title":"PLoS Pathog"},{"issue":"6","key":"11590_CR48","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3390\/antibiotics10060702","volume":"10","author":"IAA Ali","year":"2021","unstructured":"Ali IAA, Matinlinna JP, L\u00e9vesque CM, Neelakantan P (2021) Trans-cinnamaldehyde attenuates enterococcus faecalis virulence and inhibits biofilm formation. Antibiot (Basel) 10(6):702. https:\/\/doi.org\/10.3390\/antibiotics10060702","journal-title":"Antibiot (Basel)"},{"issue":"7","key":"11590_CR49","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.joen.2016.03.015","volume":"42","author":"M Barbosa-Ribeiro","year":"2016","unstructured":"Barbosa-Ribeiro M, De-Jesus-Soares A, Zaia AA, Ferraz CC, Almeida JF, Gomes BP (2016) Antimicrobial susceptibility and characterization of virulence genes of enterococcus faecalis isolates from teeth with failure of the endodontic treatment. J Endod 42(7):1022\u20131028. https:\/\/doi.org\/10.1016\/j.joen.2016.03.015","journal-title":"J Endod"},{"issue":"8","key":"11590_CR50","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/iej.12517","volume":"49","author":"T Vouzara","year":"2016","unstructured":"Vouzara T, Koulaouzidou E, Ziouti F, Economides N (2016) Combined and independent cytotoxicity of sodium hypochlorite, ethylenediaminetetraacetic acid and chlorhexidine. Int Endod J 49(8):764\u2013773","journal-title":"Int Endod J"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11590-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11590-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11590-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:04:21Z","timestamp":1771974261000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11590-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11590"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11590-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"5 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the ethical committee of Ardabil University of Medical Sciences (Reference number: IR.ARUMS.REC.1402.226).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This study used previously collected and archived clinical isolates of Enterococcus faecalis. No new human participants or animals were involved, and therefore written informed consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"419"}}