{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:20:15Z","timestamp":1773926415905,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11660-x","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:45:10Z","timestamp":1773913510000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The hippocampus under influence: structural effects of synthetic and natural psychotropic medications"],"prefix":"10.1007","volume":"53","author":[{"given":"Melissa","family":"Santaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halford","family":"Warlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Causicaa","family":"Chandramohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathmica","family":"Chandramohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armena","family":"Jafarmadar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Joubran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Koleng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Regine","family":"Owens-Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Rubinos","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Sardinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent S.","family":"Gallicchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"3","key":"11660_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00213-007-0906-9","volume":"195","author":"K Yucel","year":"2007","unstructured":"Yucel K, McKinnon MC, Taylor VH, Macdonald K, Alda M, Young LT, MacQueen GM (2007) Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study. Psychopharmacology 195(3):357\u2013367. https:\/\/doi.org\/10.1007\/s00213-007-0906-9 PMID: 17705060","journal-title":"Psychopharmacology"},{"key":"11660_CR2","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41386-021-01246-5","volume":"47","author":"Q Gallet","year":"2022","unstructured":"Gallet Q, Bouteloup V, Locatelli M et al (2022) Benzodiazepine use and neuroimaging markers of Alzheimer\u2019s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort. Neuropsychopharmacol 47:1114\u20131120. https:\/\/doi.org\/10.1038\/s41386-021-01246-5","journal-title":"Neuropsychopharmacol"},{"key":"11660_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12916-024-03437-5","volume":"22","author":"Iv Hofe","year":"2024","unstructured":"Hofe Iv, Stricker BH, Vernooij MW et al (2024) Benzodiazepine use in relation to long-term dementia risk and imaging markers of neurodegeneration: a population-based study. BMC Med 22:266. https:\/\/doi.org\/10.1186\/s12916-024-03437-5","journal-title":"BMC Med"},{"key":"11660_CR4","doi-asserted-by":"publisher","unstructured":"Cheng VY, Bonin RP, Chiu MW, Newell JG, MacDonald JF, Orser BA (2006) Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology. 105(2):325\u201333. https:\/\/doi.org\/10.1097\/00000542-200608000-00015. PMID: 16871066","DOI":"10.1097\/00000542-200608000-00015"},{"key":"11660_CR5","unstructured":"Zeng W et al (2022) Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression. Neurosci Res. https:\/\/pubmed.ncbi.nlm.nih.gov\/36039579\/"},{"issue":"5","key":"11660_CR6","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000524400","volume":"17","author":"L Steven","year":"2022","unstructured":"Steven L, Dubovsky (2022) Dori Marshall; benzodiazepines remain important therapeutic options in psychiatric practice. Psychother Psychosom 17(5):307\u2013334. https:\/\/doi.org\/10.1159\/000524400","journal-title":"Psychother Psychosom"},{"key":"11660_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/dta.2211","volume":"10","author":"KR Manchester","year":"2018","unstructured":"Manchester KR, Lomas EC, Waters L, Dempsey FC, Maskell PD (2018) The emergence of new psychoactive substance (NPS) benzodiazepines: A review. Drug Test Anal 10:37\u201353. https:\/\/doi.org\/10.1002\/dta.2211","journal-title":"Drug Test Anal"},{"key":"11660_CR8","doi-asserted-by":"publisher","unstructured":"Bollinger K, Weimer BL, Heller D, Bynum N, Grabenauer, Megan, Pressley, DeMia, Smiley-McDonald (2021) Hope. Benzodiazepines reported in NFLIS-Drug, 2015 to 2018. Forensic Science International: Synergy. 3. 100138. https:\/\/doi.org\/10.1016\/j.fsisyn.2021.100138","DOI":"10.1016\/j.fsisyn.2021.100138"},{"issue":"1","key":"11660_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.23736\/S0031-0808.25.05330-3","volume":"67","author":"R Melcarne","year":"2025","unstructured":"Melcarne R, Bernasconi S, Del Prete M, Artizzu S, Guttmann S, Ciprandi G, Gemignani A (2025) Deprescription of benzodiazepines and its management according to an overlapping strategy with a low-dose multicomponent medication: a Delphi consensus. Panminerva Med 67(1):14\u201326. https:\/\/doi.org\/10.23736\/S0031-0808.25.05330-3","journal-title":"Panminerva Med"},{"key":"11660_CR10","doi-asserted-by":"publisher","first-page":"g5205","DOI":"10.1136\/bmj.g5205","volume":"349","author":"S de Billioti","year":"2014","unstructured":"de Billioti S, Moride Y, Ducruet T, Kurth T, Verdoux H, Tournier M, Pariente A, B\u00e9gaud B (2014) Benzodiazepine use and risk of Alzheimer\u2019s disease: Case-control study. BMJ 349:g5205. https:\/\/doi.org\/10.1136\/bmj.g5205","journal-title":"BMJ"},{"key":"11660_CR11","doi-asserted-by":"publisher","first-page":"e6231","DOI":"10.1136\/bmj.e6231","volume":"345","author":"S de Billioti","year":"2012","unstructured":"de Billioti S, B\u00e9gaud B, Bazin F, Verdoux H, Dartigues JF, P\u00e9r\u00e8s K, Kurth T, Pariente A (2012) Benzodiazepine use and risk of dementia: Prospective population based study. BMJ 345:e6231. https:\/\/doi.org\/10.1136\/bmj.e6231","journal-title":"BMJ"},{"issue":"5","key":"11660_CR12","doi-asserted-by":"publisher","first-page":"e0127836","DOI":"10.1371\/journal.pone.0127836","volume":"10","author":"G Zhong","year":"2015","unstructured":"Zhong G, Wang Y, Zhang Y, Zhao Y, Wang C (2015) Association between benzodiazepine use and dementia: A meta-analysis. PLoS ONE 10(5):e0127836. https:\/\/doi.org\/10.1371\/journal.pone.0127836","journal-title":"PLoS ONE"},{"key":"11660_CR13","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fnagi.2019.00344","volume":"11","author":"By the American Geriatrics Society Beers Criteria\u00ae Update Expert Panel","year":"2019","unstructured":"By the American Geriatrics Society Beers Criteria\u00ae Update Expert Panel (2019) Benzodiazepine use and risk of Alzheimer\u2019s disease: A review of epidemiological findings. Front Aging Neurosci 11:344. https:\/\/doi.org\/10.3389\/fnagi.2019.00344","journal-title":"Front Aging Neurosci"},{"key":"11660_CR14","doi-asserted-by":"publisher","first-page":"i90","DOI":"10.1136\/bmj.i90","volume":"352","author":"SL Gray","year":"2016","unstructured":"Gray SL, Dublin S, Yu O, Walker R, Anderson M, Hubbard RA, Crane PK, Larson EB (2016) Benzodiazepine use and risk of incident dementia or cognitive decline: Prospective population-based study. BMJ 352:i90. https:\/\/doi.org\/10.1136\/bmj.i90","journal-title":"BMJ"},{"issue":"3","key":"11660_CR15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0887-6177(03)00096-9","volume":"19","author":"MJ Barker","year":"2004","unstructured":"Barker MJ, Greenwood KM, Jackson M, Crowe SF (2004) Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: A meta-analysis. Arch Clin Neuropsychol 19(3):437\u2013454 PMID: 15033227","journal-title":"Arch Clin Neuropsychol"},{"issue":"7","key":"11660_CR16","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/arclin\/acx120","volume":"33","author":"SF Crowe","year":"2018","unstructured":"Crowe SF, Stranks EK (2018) The residual medium and long-term cognitive effects of benzodiazepine use: An updated meta-analysis. Arch Clin Neuropsychol 33(7):901\u2013911 PMID: 29309555","journal-title":"Arch Clin Neuropsychol"},{"key":"11660_CR17","doi-asserted-by":"crossref","unstructured":"del Cerro S, Jung M, Lynch G (1992) Benzodiazepines block long-term potentiation in slices of hippocampus and piriform cortex. Neuroscience, 49(1), 1\u20136. PMID: 1407540","DOI":"10.1016\/0306-4522(92)90071-9"},{"key":"11660_CR18","doi-asserted-by":"crossref","unstructured":"Furukawa Tomonori N, Yoshikazu S, Shuji M, Nozomu N, Ayaka U (2021) Shinya Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice. Frontiers in Aging Neuroscience. ISSN\u2009=\u20091663\u20134365. DOI\u2009=\u200910.3389\/fnagi.2021.777404","DOI":"10.3389\/fnagi.2021.777404"},{"key":"11660_CR19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/mp.2015.4","volume":"20","author":"M Alda","year":"2015","unstructured":"Alda M (2015) Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics. Mol Psychiatry 20:661\u2013670. https:\/\/doi.org\/10.1038\/mp.2015.4","journal-title":"Mol Psychiatry"},{"key":"11660_CR20","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ejphar.2014.06.042","volume":"740","author":"MA Ramadhan Oruch","year":"2014","unstructured":"Ramadhan Oruch MA, Elderbi HA, Khattab, Ian F, Pryme (2014) Anders Lund, Lithium: A review of pharmacology, clinical uses, and toxicity. Eur J Pharmacol 740:464\u2013473. https:\/\/doi.org\/10.1016\/j.ejphar.2014.06.042","journal-title":"Eur J Pharmacol"},{"key":"11660_CR21","doi-asserted-by":"crossref","unstructured":"Olaibi OK et al (2014) Effects of chronic administration of gabapentin and carbamazepine on hippocampal histology in adult rats. [Article]. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4117164\/","DOI":"10.5214\/ans.0972.7531.210206"},{"key":"11660_CR22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.pbb.2018.07.005","volume":"170","author":"S Tan","year":"2018","unstructured":"Tan S, Metzger DB, Jung ME (2018) Chronic benzodiazepine suppresses translocator protein and elevates amyloid \u03b2 in mice. Pharmacol Biochem Behav 170:90\u201395. https:\/\/doi.org\/10.1016\/j.pbb.2018.07.005","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"11660_CR23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1017\/S0033291713001165","volume":"44","author":"T Hajek","year":"2014","unstructured":"Hajek T, Bauer M, Simhandl C, Rybakowski JK, O\u2019Donovan C, Pfennig A (2014) Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response. Psychol Med 44(3):507\u2013517. https:\/\/doi.org\/10.1017\/S0033291713001165","journal-title":"Psychol Med"},{"issue":"4","key":"11660_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/npp.2010.41","volume":"12","author":"IK Lyoo","year":"2010","unstructured":"Lyoo IK, Dager SR, Kim JE, Yoon SJ, Friedman SD, Dunner DL, Renshaw PF (2010) Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: A longitudinal brain imaging study. Bipolar Disord 12(4):362\u2013370. https:\/\/doi.org\/10.1038\/npp.2010.41","journal-title":"Bipolar Disord"},{"issue":"2","key":"11660_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/WNR.0b013e3282f48108","volume":"19","author":"LC Foland","year":"2008","unstructured":"Foland LC, Altshuler LL, Sugar CA, Montrose DM, Lee AD, Evans AC, Thompson PM (2008) Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium. NeuroReport 19(2):221\u2013224. https:\/\/doi.org\/10.1097\/WNR.0b013e3282f48108","journal-title":"NeuroReport"},{"issue":"1","key":"11660_CR26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41398-021-01695-y","volume":"11","author":"AB Palmos","year":"2021","unstructured":"Palmos AB, Duarte R, Rayner C, Mahoney CJ, Barrera A, Dar K, Zunszain PA (2021) Lithium treatment and human hippocampal neurogenesis. Translational Psychiatry 11(1):433. https:\/\/doi.org\/10.1038\/s41398-021-01695-y","journal-title":"Translational Psychiatry"},{"issue":"12","key":"11660_CR27","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1111\/j.1360-0443.2011.03563.x","volume":"106","author":"M Lader","year":"2011","unstructured":"Lader M (2011) Benzodiazepines revisited\u2014Will we ever learn? Addiction 106(12):2086\u20132109. https:\/\/doi.org\/10.1111\/j.1360-0443.2011.03563.x","journal-title":"Addiction"},{"issue":"3","key":"11660_CR28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/hbm.21239","volume":"33","author":"TGM van Erp","year":"2012","unstructured":"van Erp TGM, Thompson PM, Kiesepp\u00e4 T, King-Casas B, Boedhoe PSW, Schmaal L, Cannon TD (2012) Hippocampal morphology in lithium- and non-lithium- treated bipolar I disorder patients, non-bipolar co-twins, and control twins. Hum Brain Mapp 33(3):501\u2013510. https:\/\/doi.org\/10.1002\/hbm.21239","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"11660_CR29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/19768354.2018.1487334","volume":"22","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Li N, Chen T, Lv X, Zhao Y, Cheng Y, Du H (2018) Lithium chloride promotes proliferation of neural stem cells in vitro, possibly by triggering the Wnt signaling pathway. Anim Cells Syst 22(6):387\u2013394. https:\/\/doi.org\/10.1080\/19768354.2018.1487334","journal-title":"Anim Cells Syst"},{"issue":"12","key":"11660_CR30","doi-asserted-by":"publisher","first-page":"e3215","DOI":"10.1002\/brb3.3215","volume":"11","author":"M Jahandideh","year":"2021","unstructured":"Jahandideh M, Ebrahimi E, Farzaei MH (2021) The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology. Brain Behav 11(12):e3215. https:\/\/doi.org\/10.1002\/brb3.3215","journal-title":"Brain Behav"},{"issue":"8","key":"11660_CR31","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/bdi.12449","volume":"18","author":"VJR De-Paula","year":"2016","unstructured":"De-Paula VJR, Kerr DS, Forlenza OV (2016) Long-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations. Bipolar Disord 18(8):692\u2013695. https:\/\/doi.org\/10.1111\/bdi.12449","journal-title":"Bipolar Disord"},{"issue":"6","key":"11660_CR32","doi-asserted-by":"publisher","first-page":"e846","DOI":"10.1038\/tp.2016.97","volume":"6","author":"S Zung","year":"2016","unstructured":"Zung S, Souza-Duran FL, Soeiro-de-Souza MG, Santoro ML, Tavares D, Machado-Vieira R, Moreno RA (2016) The influence of lithium on hippocampal volume in elderly bipolar patients: A study using voxel-based morphometry. Translational Psychiatry 6(6):e846. https:\/\/doi.org\/10.1038\/tp.2016.97","journal-title":"Translational Psychiatry"},{"issue":"2","key":"11660_CR33","first-page":"153","volume":"464","author":"YS Kim","year":"2009","unstructured":"Kim YS, Lee JH, Lee SK (2009) Protective effect of gabapentin on N-methyl-D- aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons. Neurosci Lett 464(2):153\u2013157. https:\/\/pubmed.ncbi.nlm.nih.gov\/19151547\/","journal-title":"Neurosci Lett"},{"key":"11660_CR34","unstructured":"Traa BS et al (2008) Gabapentin: neuroprotection and seizure suppression in models of ischemic injury. [Article]. PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/18391849\/"},{"issue":"11","key":"11660_CR35","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1111\/bph.14149.14","volume":"175","author":"YP Yu","year":"2018","unstructured":"Yu YP, Gong N, Kweon TD, Vo B, Luo ZD (2018) Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on presynaptic CaV\u03b12\u03b41 subunits. Br J Pharmacol 175(11):2348\u20132361. https:\/\/doi.org\/10.1111\/bph.14149.14","journal-title":"Br J Pharmacol"},{"key":"11660_CR36","doi-asserted-by":"publisher","first-page":"100326","DOI":"10.1016\/j.prmcm.2023.100326","volume":"9","author":"K DilipKumar Chanchal, Singh","year":"2023","unstructured":"DilipKumar C, Singh K, Bhushan B, Singh Chaudhary J, Kumar S, Varma AK, Garg (2023) An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes. Pharmacol Res Mod Chin Med 9:100326\u2013100326. https:\/\/doi.org\/10.1016\/j.prmcm.2023.100326","journal-title":"Pharmacol Res Mod Chin Med"},{"key":"11660_CR37","doi-asserted-by":"publisher","first-page":"111202","DOI":"10.1016\/j.brainresbull.2025.111202","volume":"221","author":"Q Fu","year":"2025","unstructured":"Fu Q, Yu Q, Luo H, Liu Z, Ma X, Wang H, Cheng Z (2025) Protective effects of wogonin in the treatment of central nervous system and degenerative diseases. Brain Res Bull 221:111202. https:\/\/doi.org\/10.1016\/j.brainresbull.2025.111202","journal-title":"Brain Res Bull"},{"key":"11660_CR38","doi-asserted-by":"publisher","unstructured":"Huang DS, Yu YC, Wu CH, Lin JY (2017) Protective Effects of Wogonin against Alzheimer\u2019s Disease by Inhibition of Amyloidogenic Pathway. Evidence-based complementary and alternative medicine: eCAM, 2017, 3545169. https:\/\/doi.org\/10.1155\/2017\/3545169","DOI":"10.1155\/2017\/3545169"},{"issue":"1","key":"11660_CR39","doi-asserted-by":"publisher","first-page":"e41002","DOI":"10.1016\/j.heliyon.2024.e41002","volume":"11","author":"L Si","year":"2024","unstructured":"Si L, An Y, Zhou J, Lai Y (2024) Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms. Heliyon 11(1):e41002. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e41002","journal-title":"Heliyon"},{"key":"11660_CR40","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s42826-020-00058-w","volume":"36","author":"MA Shah","year":"2020","unstructured":"Shah MA, Park DJ, Kang JB, Kim MO, Koh PO (2020) Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice. Lab Anim Res 36:32. https:\/\/doi.org\/10.1186\/s42826-020-00058-w","journal-title":"Lab Anim Res"},{"issue":"19","key":"11660_CR41","doi-asserted-by":"publisher","first-page":"10428","DOI":"10.18632\/aging.205087","volume":"15","author":"S Zhu","year":"2023","unstructured":"Zhu S, Shi J, Jin Q, Zhang Y, Zhang R, Chen X, Wang C, Shi T, Li L (2023) Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice. Aging 15(19):10428\u201310452. https:\/\/doi.org\/10.18632\/aging.205087","journal-title":"Aging"},{"issue":"05","key":"11660_CR42","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1142\/s0192415x1650052x","volume":"44","author":"Y Chang","year":"2016","unstructured":"Chang Y, Lu CW, Lin TY, Huang SK, Wang SJ (2016) Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats. Am J Chin Med 44(05):943\u2013962. https:\/\/doi.org\/10.1142\/s0192415x1650052x","journal-title":"Am J Chin Med"},{"key":"11660_CR43","doi-asserted-by":"publisher","unstructured":"Yang J, Wu X, Yu H, Liao X, Teng L (2014) NMDA receptor-mediated neuroprotective effect of the Scutellaria baicalensis Georgi extract on the excitotoxic neuronal cell death in primary rat cortical cell cultures. The Scientific World Journal, 459549. https:\/\/doi.org\/10.1155\/2014\/459549","DOI":"10.1155\/2014\/459549"},{"key":"11660_CR44","doi-asserted-by":"publisher","first-page":"933704","DOI":"10.3389\/fpsyt.2022.933704","volume":"13","author":"L Zhou","year":"2022","unstructured":"Zhou L, Xiong JY, Chai YQ, Huang L, Tang ZY, Zhang XF, Liu B, Zhang JT (2022) Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system. Front Psychiatry 13:933704. https:\/\/doi.org\/10.3389\/fpsyt.2022.933704","journal-title":"Front Psychiatry"},{"issue":"8","key":"11660_CR45","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1080\/1028415X.2017.1323609","volume":"21","author":"M\u00c1 P\u00e9rez","year":"2018","unstructured":"P\u00e9rez M\u00c1, Pe\u00f1aloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A (2018) n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats. Nutr Neurosci 21(8):556\u2013569. https:\/\/doi.org\/10.1080\/1028415X.2017.1323609","journal-title":"Nutr Neurosci"},{"issue":"5","key":"11660_CR46","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1212\/WNL.0000000000000080","volume":"82","author":"JV Pottala","year":"2014","unstructured":"Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS (2014) Higher RBC EPA+ DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology 82(5):435\u2013442. https:\/\/doi.org\/10.1212\/WNL.0000000000000080","journal-title":"Neurology"},{"issue":"1","key":"11660_CR47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12974-016-0525-7","volume":"13","author":"D Heras-Sandoval","year":"2016","unstructured":"Heras-Sandoval D, Pedraza-Chaverri J, P\u00e9rez-Rojas JM (2016) Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer\u2019s disease. J Neuroinflamm 13(1):61. https:\/\/doi.org\/10.1186\/s12974-016-0525-7","journal-title":"J Neuroinflamm"},{"key":"11660_CR48","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbi.2023.10.018","volume":"115","author":"J Wen","year":"2024","unstructured":"Wen J, Satyanarayanan SK, Li A, Yan L, Zhao Z, Yuan Q, Su K-P, Su H (2024) Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function. Brain Behav Immun 115:335\u2013355. https:\/\/doi.org\/10.1016\/j.bbi.2023.10.018","journal-title":"Brain Behav Immun"},{"issue":"7","key":"11660_CR49","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/1028415X.2023.2245996","volume":"27","author":"S Ziaei","year":"2024","unstructured":"Ziaei S, Mohammadi S, Hasani M, Morvaridi M, Belan\u010di\u0107 A, Daneshzad E, Saleh SK, Adly HM, Heshmati J (2024) A systematic review and meta-analysis of the omega- 3 fatty acids effects on brain-derived neurotrophic factor (BDNF). Nutr Neurosci 27(7):715\u2013725. https:\/\/doi.org\/10.1080\/1028415X.2023.2245996","journal-title":"Nutr Neurosci"},{"key":"11660_CR50","doi-asserted-by":"publisher","first-page":"1271203","DOI":"10.3389\/fphar.2023.1271203","volume":"14","author":"P Meera","year":"2023","unstructured":"Meera P, Uusi-Oukari M, Lipshutz GS, Wallner M (2023) GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions. Front Pharmacol 14:1271203. https:\/\/doi.org\/10.3389\/fphar.2023.1271203","journal-title":"Front Pharmacol"},{"key":"11660_CR51","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fneur.2020.00614","volume":"11","author":"S Manzano","year":"2020","unstructured":"Manzano S, Ag\u00fcera L, Aguilar M, Olazar\u00e1n J (2020) A Review on Tramiprosate (Homotaurine) in Alzheimer\u2019s Disease and Other Neurocognitive Disorders. Front Neurol 11:614. https:\/\/doi.org\/10.3389\/fneur.2020.00614","journal-title":"Front Neurol"},{"issue":"8","key":"11660_CR52","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1021\/acschemneuro.1c00057.15","volume":"12","author":"X Zou","year":"2021","unstructured":"Zou X, Himbert S, Dujardin A, Juhasz J, Ros S, St\u00f6ver HDH, Rheinst\u00e4dter MC (2021) Curcumin and Homotaurine Suppress Amyloid-\u03b225\u201335 Aggregation in Synthetic Brain Membranes. ACS Chem Neurosci 12(8):1395\u20131405. https:\/\/doi.org\/10.1021\/acschemneuro.1c00057.15","journal-title":"ACS Chem Neurosci"},{"issue":"3","key":"11660_CR53","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3233\/JAD-150","volume":"50","author":"G Spalletta","year":"2016","unstructured":"Spalletta G, Cravello L, Gianni W, Piras F, Iorio M, Cacciari C, Casini AR, Chiapponi C, Sancesario G, Fratangeli C, Orfei MD, Caltagirone C, Piras F (2016) Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment. J Alzheimer\u2019s disease: JAD 50(3):807\u2013816. https:\/\/doi.org\/10.3233\/JAD-150","journal-title":"J Alzheimer\u2019s disease: JAD"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11660-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11660-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11660-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:45:17Z","timestamp":1773913517000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11660-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11660"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11660-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"19 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Our research did not involve human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Our research did not involve human subjects. Consent to participate is not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"514"}}