{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:54:38Z","timestamp":1784055278409,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["750038"],"award-info":[{"award-number":["750038"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11667-4","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:37:00Z","timestamp":1773661020000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early modulatory effects of Porphyromonas gingivalis and Lactobacillus salivarius on oncogenic processes in dysplastic oral keratinocytes"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9781-5977","authenticated-orcid":false,"given":"Umme","family":"Samia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-9646","authenticated-orcid":false,"given":"Tamara","family":"Vlajic Tovilovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-4696","authenticated-orcid":false,"given":"Ilinka","family":"Pecinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-1186","authenticated-orcid":false,"given":"Milena","family":"Radunovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-8355","authenticated-orcid":false,"given":"Sanja","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-5332","authenticated-orcid":false,"given":"Milos","family":"Lazarevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-8193","authenticated-orcid":false,"given":"Dijana","family":"Mitic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-0829","authenticated-orcid":false,"given":"Milica","family":"Jaksic Karisik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-9313","authenticated-orcid":false,"given":"Nadja","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-7589","authenticated-orcid":false,"given":"Jelena","family":"Carkic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-887X","authenticated-orcid":false,"given":"Maria Cristina","family":"Curia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-7210","authenticated-orcid":false,"given":"Jelena","family":"Milasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"11667_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"11667_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1600-0757.2011.00401.x","volume":"57","author":"NW Johnson","year":"2011","unstructured":"Johnson NW, Jayasekara P, Amarasinghe AAHK (2011) Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontol 2000 57:19\u201337. https:\/\/doi.org\/10.1111\/j.1600-0757.2011.00401.x","journal-title":"Periodontol 2000"},{"key":"11667_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","volume":"36","author":"S Warnakulasuriya","year":"2007","unstructured":"Warnakulasuriya S, Johnson NW, van der Waal I (2007) Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med 36:575\u2013580. https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00582.x","journal-title":"J Oral Pathol Med"},{"key":"11667_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/ijc.28754","volume":"136","author":"KR Dionne","year":"2015","unstructured":"Dionne KR, Warnakulasuriya S, Binti Zain R, Cheong SC (2015) Potentially malignant disorders of the oral cavity: current practice and future directions in the clinic and laboratory. Int J Cancer 136:503\u2013515. https:\/\/doi.org\/10.1002\/ijc.28754","journal-title":"Int J Cancer"},{"key":"11667_CR5","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1111\/odi.13704","volume":"27","author":"S Warnakulasuriya","year":"2021","unstructured":"Warnakulasuriya S, Kujan O, Aguirre-Urizar JM et al (2021) Oral potentially malignant disorders: a consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis 27:1862\u20131880. https:\/\/doi.org\/10.1111\/odi.13704","journal-title":"Oral Dis"},{"key":"11667_CR6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.oooo.2024.03.006","volume":"137","author":"ED Piemonte","year":"2024","unstructured":"Piemonte ED, Gilligan GM, Garola F et al (2024) Differences among oral carcinomas arising de novo from those associated with oral potentially malignant disorders: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 137:613\u2013631. https:\/\/doi.org\/10.1016\/j.oooo.2024.03.006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"11667_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/prd.12558","volume":"96","author":"GN Belibasakis","year":"2024","unstructured":"Belibasakis GN, Seneviratne CJ, Jayasinghe RD et al (2024) Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer. Periodontol 2000 96:95\u2013111. https:\/\/doi.org\/10.1111\/prd.12558","journal-title":"Periodontol 2000"},{"key":"11667_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00203-020-02011-w","volume":"203","author":"AK Rai","year":"2021","unstructured":"Rai AK, Panda M, Das AK et al (2021) Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation. Arch Microbiol 203:137\u2013152. https:\/\/doi.org\/10.1007\/s00203-020-02011-w","journal-title":"Arch Microbiol"},{"key":"11667_CR9","doi-asserted-by":"publisher","first-page":"120008","DOI":"10.1016\/j.lfs.2021.120008","volume":"285","author":"D Singh","year":"2021","unstructured":"Singh D, Khan MA, Siddique HR (2021) Therapeutic implications of probiotics in microbiota dysbiosis: a special reference to the liver and oral cancers. Life Sci 285:120008. https:\/\/doi.org\/10.1016\/j.lfs.2021.120008","journal-title":"Life Sci"},{"key":"11667_CR10","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s11033-025-10926-0","volume":"52","author":"A Khoshbayan","year":"2025","unstructured":"Khoshbayan A, Narimisa N, Razavi S et al (2025) The interactions of Fusobacterium nucleatum and Porphyromonas gingivalis with microRNAs: contributions to oral squamous cell carcinoma. Mol Biol Rep 52:821. https:\/\/doi.org\/10.1007\/s11033-025-10926-0","journal-title":"Mol Biol Rep"},{"key":"11667_CR11","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/cmi.12569","volume":"18","author":"MN Sztukowska","year":"2016","unstructured":"Sztukowska MN, Ojo A, Ahmed S et al (2016) Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells. Cell Microbiol 18:844\u2013858. https:\/\/doi.org\/10.1111\/cmi.12569","journal-title":"Cell Microbiol"},{"key":"11667_CR12","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.3390\/cancers17213478","volume":"17","author":"K Starska-Kowarska","year":"2025","unstructured":"Starska-Kowarska K (2025) The role of Porphyromonas gingivalis in oral carcinogenesis and progression by remodelling the tumour microenvironment: a narrative review. Cancers (Basel) 17:3478. https:\/\/doi.org\/10.3390\/cancers17213478","journal-title":"Cancers (Basel)"},{"key":"11667_CR13","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s00262-022-03348-5","volume":"72","author":"ZC Guo","year":"2023","unstructured":"Guo ZC, Jing SL, Jumatai S, Gong ZC (2023) Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating neutrophil chemotaxis in the tumour microenvironment. Cancer Immunol Immunother 72:1523\u20131539. https:\/\/doi.org\/10.1007\/s00262-022-03348-5","journal-title":"Cancer Immunol Immunother"},{"key":"11667_CR14","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1177\/0022034520905594","volume":"99","author":"L Wen","year":"2020","unstructured":"Wen L, Mu W, Lu H et al (2020) Porphyromonas gingivalis promotes oral squamous cell carcinoma progression in an immune microenvironment. J Dent Res 99:666\u2013675. https:\/\/doi.org\/10.1177\/0022034520905594","journal-title":"J Dent Res"},{"key":"11667_CR15","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1080\/23744235.2019.1653490","volume":"51","author":"Q Li","year":"2019","unstructured":"Li Q, Zhou J, Lin L et al (2019) Porphyromonas gingivalis degrades integrin \u03b21 and induces AIF-mediated apoptosis of epithelial cells. Infect Dis (Lond) 51:793\u2013801. https:\/\/doi.org\/10.1080\/23744235.2019.1653490","journal-title":"Infect Dis (Lond)"},{"key":"11667_CR16","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.identj.2024.03.017","volume":"74","author":"A Al-Asfour","year":"2024","unstructured":"Al-Asfour A, Bhardwaj RG, Karched M (2024) Growth suppression of oral squamous cell carcinoma cells by Lactobacillus acidophilus. Int Dent J 74:1151\u20131160. https:\/\/doi.org\/10.1016\/j.identj.2024.03.017","journal-title":"Int Dent J"},{"key":"11667_CR17","doi-asserted-by":"publisher","first-page":"422","DOI":"10.4081\/oncol.2019.422","volume":"13","author":"L Mendoza","year":"2019","unstructured":"Mendoza L (2019) Potential effect of probiotics in the treatment of breast cancer. Oncol Rev 13:422. https:\/\/doi.org\/10.4081\/oncol.2019.422","journal-title":"Oncol Rev"},{"key":"11667_CR18","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00284-019-01679-8","volume":"76","author":"A G\u00f3rska","year":"2019","unstructured":"G\u00f3rska A, Przystupski D, Niemczura MJ, Kulbacka J (2019) Probiotic bacteria: a promising tool in cancer prevention and therapy. Curr Microbiol 76:939\u2013949. https:\/\/doi.org\/10.1007\/s00284-019-01679-8","journal-title":"Curr Microbiol"},{"key":"11667_CR19","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.3390\/nu11102453","volume":"11","author":"M Molska","year":"2019","unstructured":"Molska M, Regu\u0142a J (2019) Potential mechanisms of probiotics action in the prevention and treatment of colorectal cancer. Nutrients 11:2453. https:\/\/doi.org\/10.3390\/nu11102453","journal-title":"Nutrients"},{"key":"11667_CR20","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.3390\/nu13082674","volume":"13","author":"K Ka\u017amierczak-Siedlecka","year":"2021","unstructured":"Ka\u017amierczak-Siedlecka K, Roviello G, Catalano M, Polom K (2021) Gut microbiota modulation in the context of immune-related aspects of Lactobacillus spp. and Bifidobacterium spp. in gastrointestinal cancers. Nutrients 13:2674. https:\/\/doi.org\/10.3390\/nu13082674","journal-title":"Nutrients"},{"key":"11667_CR21","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1038\/s41598-024-63998-6","volume":"14","author":"Y Nami","year":"2024","unstructured":"Nami Y, Tavallaei O, Kiani A et al (2024) Anti-oral cancer properties of potential probiotic lactobacilli isolated from traditional milk, cheese, and yogurt. Sci Rep 14:6398. https:\/\/doi.org\/10.1038\/s41598-024-63998-6","journal-title":"Sci Rep"},{"key":"11667_CR22","first-page":"152","volume":"8","author":"Y Wang","year":"2016","unstructured":"Wang Y, Zhang M, Fang B, Chen L (2016) Effects of Lactobacillus salivarius on oral cancer cell proliferation and apoptosis in vitro. Mol Med Rep 8:152\u2013158","journal-title":"Mol Med Rep"},{"key":"11667_CR23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"11667_CR24","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.3390\/molecules27196275","volume":"27","author":"AS Chatterley","year":"2022","unstructured":"Chatterley AS, Laity P, Holland C et al (2022) Broadband multidimensional spectroscopy identifies the amide II vibrations in silkworm films. Molecules 27:6275. https:\/\/doi.org\/10.3390\/molecules27196275","journal-title":"Molecules"},{"key":"11667_CR25","doi-asserted-by":"publisher","first-page":"103145","DOI":"10.1016\/j.pdpdt.2022.103145","volume":"40","author":"M Shakeel","year":"2022","unstructured":"Shakeel M, Majeed MI, Nawaz H et al (2022) Surface-enhanced Raman spectroscopy for the characterization of pellets of biofilm-forming bacterial strains of Staphylococcus epidermidis. Photodiagnosis Photodyn Ther 40:103145. https:\/\/doi.org\/10.1016\/j.pdpdt.2022.103145","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"11667_CR26","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/S0006-3495(94)80723-4","volume":"67","author":"RN Lewis","year":"1994","unstructured":"Lewis RN, McElhaney RN, Pohle W, Mantsch HH (1994) Components of the carbonyl stretching band in the infrared spectra of hydrated 1,2-diacylglycerolipid bilayers: a reevaluation. Biophys J 67:2367\u20132375. https:\/\/doi.org\/10.1016\/S0006-3495(94)80723-4","journal-title":"Biophys J"},{"key":"11667_CR27","doi-asserted-by":"publisher","first-page":"6803","DOI":"10.1007\/s00216-015-8851-7","volume":"407","author":"D Kusi\u0107","year":"2015","unstructured":"Kusi\u0107 D, Kampe B, Ramoji A et al (2015) Raman spectroscopic differentiation of planktonic bacteria and biofilms. Anal Bioanal Chem 407:6803\u20136813. https:\/\/doi.org\/10.1007\/s00216-015-8851-7","journal-title":"Anal Bioanal Chem"},{"key":"11667_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/antibiotics14010106","volume":"14","author":"T Gani\u0107","year":"2025","unstructured":"Gani\u0107 T, Pe\u0107inar I, Nikoli\u0107 B et al (2025) Evaluation of cinnamon essential oil and its emulsion on biofilm-associated components of Acinetobacter baumannii clinical strains. Antibiot (Basel) 14:106. https:\/\/doi.org\/10.3390\/antibiotics14010106","journal-title":"Antibiot (Basel)"},{"key":"11667_CR29","doi-asserted-by":"publisher","first-page":"120663","DOI":"10.1016\/j.saa.2021.120663","volume":"268","author":"K Serec","year":"2022","unstructured":"Serec K, Babi\u0107 SD, Tomi\u0107 S (2022) Magnesium ions reversibly bind to DNA double-stranded helix in thin films. Spectrochim Acta Mol Biomol Spectrosc 268:120663. https:\/\/doi.org\/10.1016\/j.saa.2021.120663","journal-title":"Spectrochim Acta Mol Biomol Spectrosc"},{"key":"11667_CR30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/1471-2180-9-107","volume":"9","author":"PG Stathopoulou","year":"2009","unstructured":"Stathopoulou PG, Galicia JC, Benakanakere MR et al (2009) Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism. BMC Microbiol 9:107. https:\/\/doi.org\/10.1186\/1471-2180-9-107","journal-title":"BMC Microbiol"},{"key":"11667_CR31","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.3390\/ijms25073611","volume":"25","author":"L Y\u00e1\u00f1ez","year":"2024","unstructured":"Y\u00e1\u00f1ez L, Soto C, Tapia H et al (2024) Co-culture of P. gingivalis and F. nucleatum synergistically elevates IL-6 expression via TLR4 signaling in oral keratinocytes. Int J Mol Sci 25:3611. https:\/\/doi.org\/10.3390\/ijms25073611","journal-title":"Int J Mol Sci"},{"key":"11667_CR32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fcimb.2017.00057","volume":"7","author":"F Geng","year":"2017","unstructured":"Geng F, Liu J, Guo Y et al (2017) Persistent exposure to Porphyromonas gingivalis promotes proliferative and invasion capabilities, and tumorigenic properties of human immortalized oral epithelial cells. Front Cell Infect Microbiol 7:57. https:\/\/doi.org\/10.3389\/fcimb.2017.00057","journal-title":"Front Cell Infect Microbiol"},{"key":"11667_CR33","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.7150\/ijms.94566","volume":"21","author":"P Rajendran","year":"2024","unstructured":"Rajendran P, Sekar R, Dhayasankar PS et al (2024) PI3K\/AKT signaling pathway mediated autophagy in oral carcinoma: a comprehensive review. Int J Med Sci 21:1165\u20131175. https:\/\/doi.org\/10.7150\/ijms.94566","journal-title":"Int J Med Sci"},{"key":"11667_CR34","doi-asserted-by":"publisher","first-page":"1886844","DOI":"10.1080\/19490976.2021.1886844","volume":"13","author":"AH Mohseni","year":"2021","unstructured":"Mohseni AH, Casolaro V, Berm\u00fadez-Humar\u00e1n LG et al (2021) Modulation of the PI3K\/Akt\/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut Microbes 13:1886844. https:\/\/doi.org\/10.1080\/19490976.2021.1886844","journal-title":"Gut Microbes"},{"key":"11667_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1039\/C9FO02476J","volume":"11","author":"G Jia","year":"2020","unstructured":"Jia G, Liu X, Che N et al (2020) Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-\u03baB and autophagy signaling pathways. Food Funct 11:270\u2013284. https:\/\/doi.org\/10.1039\/C9FO02476J","journal-title":"Food Funct"},{"key":"11667_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/sj.neo.7900127","volume":"3","author":"O Gallo","year":"2001","unstructured":"Gallo O, Franchi A, Magnelli L et al (2001) Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer: implications for tumor angiogenesis and metastasis. Neoplasia 3:53\u201361. https:\/\/doi.org\/10.1038\/sj.neo.7900127","journal-title":"Neoplasia"},{"key":"11667_CR37","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/cimb47070568","volume":"47","author":"D Mitic","year":"2025","unstructured":"Mitic D, Jaksic Karisik M, Lazarevic M et al (2025) Oral squamous cell carcinoma exosomes upregulate PIK3\/AKT, PTEN, and NOTCH signaling pathways in normal fibroblasts. Curr Issues Mol Biol 47:568. https:\/\/doi.org\/10.3390\/cimb47070568","journal-title":"Curr Issues Mol Biol"},{"key":"11667_CR38","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.3390\/pathogens12101194","volume":"12","author":"U Tomic","year":"2023","unstructured":"Tomic U, Nikolic N, Carkic J et al (2023) Streptococcus mitis and Prevotella melaninogenica influence gene expression changes in oral mucosal lesions in periodontitis patients. Pathogens 12:1194. https:\/\/doi.org\/10.3390\/pathogens12101194","journal-title":"Pathogens"},{"key":"11667_CR39","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.3390\/cancers12102797","volume":"12","author":"Q Li","year":"2020","unstructured":"Li Q, Hu Y, Zhou X et al (2020) Role of oral bacteria in the development of oral squamous cell carcinoma. Cancers (Basel) 12:2797. https:\/\/doi.org\/10.3390\/cancers12102797","journal-title":"Cancers (Basel)"},{"key":"11667_CR40","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/abbs\/gmt064","volume":"45","author":"K Bishayee","year":"2013","unstructured":"Bishayee K, Khuda-Bukhsh AR (2013) 5-Lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. Amino Acids 45:709\u2013719. https:\/\/doi.org\/10.1093\/abbs\/gmt064","journal-title":"Amino Acids"},{"key":"11667_CR41","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.3390\/cancers15082380","volume":"15","author":"BM Kennedy","year":"2023","unstructured":"Kennedy BM, Harris RE (2023) Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of colorectal cancer. Cancers (Basel) 15:2380. https:\/\/doi.org\/10.3390\/cancers15082380","journal-title":"Cancers (Basel)"},{"key":"11667_CR42","doi-asserted-by":"publisher","first-page":"652","DOI":"10.62110\/sciencein.cbl.2024.v11.652","volume":"11","author":"M Kumari","year":"2023","unstructured":"Kumari M, Chhikara BS, Singh P et al (2023) Signaling and molecular pathways implicated in oral cancer: a concise review. Chem Biol Lett 11:652. https:\/\/doi.org\/10.62110\/sciencein.cbl.2024.v11.652","journal-title":"Chem Biol Lett"},{"key":"11667_CR43","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1021\/acsinfecdis.0c00007","volume":"6","author":"G Liang","year":"2020","unstructured":"Liang G, Wang H, Shi H et al (2020) Porphyromonas gingivalis promotes the proliferation and migration of esophageal squamous cell carcinoma through the miR-194\/GRHL3\/PTEN\/Akt axis. ACS Infect Dis 6:871\u2013881. https:\/\/doi.org\/10.1021\/acsinfecdis.0c00007","journal-title":"ACS Infect Dis"},{"key":"11667_CR44","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41419-019-1877-6","volume":"10","author":"A Tauffenberger","year":"2019","unstructured":"Tauffenberger A, Fiumelli H, Almustafa S, Magistretti PJ (2019) Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling. Cell Death Dis 10:653. https:\/\/doi.org\/10.1038\/s41419-019-1877-6","journal-title":"Cell Death Dis"},{"key":"11667_CR45","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1126\/science.285.5428.736","volume":"285","author":"AO Aliprantis","year":"1999","unstructured":"Aliprantis AO, Yang RB, Mark MR et al (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285:736\u2013739. https:\/\/doi.org\/10.1126\/science.285.5428.736","journal-title":"Science"},{"key":"11667_CR46","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1002\/jrs.6204","volume":"52","author":"G Pezzotti","year":"2021","unstructured":"Pezzotti G (2021) Raman spectroscopy in cell biology and microbiology. J Raman Spectrosc 52:2348\u20132443. https:\/\/doi.org\/10.1002\/jrs.6204","journal-title":"J Raman Spectrosc"},{"key":"11667_CR47","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41420-025-02550-5","volume":"11","author":"G Peng","year":"2025","unstructured":"Peng G, Qijun R, Jiatong L et al (2025) Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections. Cell Death Discov 11:283. https:\/\/doi.org\/10.1038\/s41420-025-02550-5","journal-title":"Cell Death Discov"},{"key":"11667_CR48","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1128\/IAI.72.7.3743-3751.2004","volume":"72","author":"O Yilmaz","year":"2004","unstructured":"Yilmaz O, Jungas T, Verbeke P, Ojcius DM (2004) Activation of the phosphatidylinositol 3-kinase\/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun 72:3743\u20133751. https:\/\/doi.org\/10.1128\/IAI.72.7.3743-3751.2004","journal-title":"Infect Immun"},{"key":"11667_CR49","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.3390\/foods11111610","volume":"11","author":"Q Lu","year":"2022","unstructured":"Lu Q, Guo Y, Yang G et al (2022) Structure and anti-inflammation potential of lipoteichoic acids isolated from Lactobacillus strains. Foods 11:1610. https:\/\/doi.org\/10.3390\/foods11111610","journal-title":"Foods"},{"key":"11667_CR50","doi-asserted-by":"publisher","first-page":"13351","DOI":"10.3390\/ijms241713351","volume":"24","author":"G Pezzotti","year":"2023","unstructured":"Pezzotti G, Adachi T, Imamura H et al (2023) In situ Raman study of neurodegenerated human neuroblastoma cells exposed to outer-membrane vesicles isolated from Porphyromonas gingivalis. Int J Mol Sci 24:13351. https:\/\/doi.org\/10.3390\/ijms241713351","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11667-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11667-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11667-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:37:01Z","timestamp":1773661021000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11667-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11667"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11667-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"assertion":[{"value":"19 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of School of Dental Medicine, University of Belgrade (Date 7\/17\/2020 \/No 36\/19).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"NA.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"NA.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"502"}}