{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:49:30Z","timestamp":1775904570464,"version":"3.50.1"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170798"],"award-info":[{"award-number":["82170798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11789-9","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:20:11Z","timestamp":1775895611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of methylation in pituitary neuroendocrine tumors current insights and emerging perspectives"],"prefix":"10.1007","volume":"53","author":[{"given":"Yafei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"11789_CR1","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.3332\/ecancer.2024.1803","volume":"18","author":"K Saeed","year":"2024","unstructured":"Saeed K, Siddiqui K, Aziz HF, Shaukat F, Kadri S, Muhammad AG, Darbar A, Mahmood T (2024) Outcomes following CyberKnife robotic radiosurgery for pituitary adenomas-a large single-centre study. Ecancermedicalscience 18:1803","journal-title":"Ecancermedicalscience"},{"key":"11789_CR2","doi-asserted-by":"publisher","first-page":"e70167","DOI":"10.1111\/jne.70167","volume":"38","author":"R van der Groef","year":"2026","unstructured":"van der Groef R, Mulugeta E, Neggers S, Refardt J (2026) DNA methylation as a predictor of pituitary neuroendocrine tumour behaviour: A systematic review. J Neuroendocrinol 38:e70167","journal-title":"J Neuroendocrinol"},{"key":"11789_CR3","doi-asserted-by":"publisher","first-page":"100923","DOI":"10.1016\/j.lanepe.2024.100923","volume":"42","author":"TM Boertien","year":"2024","unstructured":"Boertien TM, Drent ML, Booij J, Majoie C, Stokkel MPM, Hoogmoed J, Pereira AM, Biermasz NR, Simsek S, Veldman RG, Weterings AJ, Vink JM, Tanck MWT, Fliers E, Bisschop PH (2024) Lanreotide versus placebo for tumour reduction in patients with a (68)Ga-DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma (GALANT study): a randomised, multicentre, phase 3 trial with blinded outcome assessment. Lancet Reg Health Eur 42:100923","journal-title":"Lancet Reg Health Eur"},{"key":"11789_CR4","unstructured":"Hiroshi N (2023) WHO Histological Classification of Pituitary Tumors. No Shinkei Geka, 51"},{"key":"11789_CR5","doi-asserted-by":"publisher","unstructured":"Nishioka H, Yamada S (2019) Cushing's Disease. J Clin Med 8(11):1951. https:\/\/doi.org\/10.3390\/jcm8111951","DOI":"10.3390\/jcm8111951"},{"key":"11789_CR6","doi-asserted-by":"publisher","unstructured":"Gheorghi\u0219an-G\u0103l\u0103\u021beanu AA, Ilie\u0219iu A, Lambrescu IM, \u021a\u0103poi DA (2023) The Complex Histopathological and Immunohistochemical Spectrum of Neuroendocrine Tumors-An Overview of the Latest Classifications. Int J Mol Sci 24(2):1418. https:\/\/doi.org\/10.3390\/ijms24021418","DOI":"10.3390\/ijms24021418"},{"key":"11789_CR7","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1073\/pnas.0510310103","volume":"103","author":"S Saxonov","year":"2006","unstructured":"Saxonov S, Berg P, Brutlag DL (2006) A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A 103:1412\u20131417","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11789_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4161\/epi.1.3.3327","volume":"1","author":"M Klug","year":"2006","unstructured":"Klug M, Rehli M (2006) Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector. Epigenetics 1:127\u2013130","journal-title":"Epigenetics"},{"key":"11789_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1042\/BJ20110392","volume":"440","author":"H Qiao","year":"2011","unstructured":"Qiao H, May JM (2011) CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a. Biochem J 440:73\u201384","journal-title":"Biochem J"},{"key":"11789_CR10","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40246-023-00457-9","volume":"17","author":"J Li","year":"2023","unstructured":"Li J, Liu D, Ren J, Li G, Zhao Z, Zhao H, Yan Q, Duan J, Liu Z (2023) Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy. Hum Genomics 17:6","journal-title":"Hum Genomics"},{"key":"11789_CR11","doi-asserted-by":"publisher","unstructured":"Eker K, Sabour Takanlou M, Sabour Takanlou L, Rostamlou A, Biray Avci C (2026) BET inhibition enhances temozolomide sensitivity in cervical cancer cells through ALDH suppression and epigenetic reprogramming. Mol Biol Rep 53(1):457. https:\/\/doi.org\/10.1007\/s11033-026-11618-z","DOI":"10.1007\/s11033-026-11618-z"},{"key":"11789_CR12","doi-asserted-by":"publisher","unstructured":"Lin TY, Chen HY, Cheng YH, et al (2026) Dysregulated methylation of the human BOLL promoter hinders germ cell development from spermatogonia to spermatids. Mol Biol Rep 53(1):477. https:\/\/doi.org\/10.1007\/s11033-026-11633-0","DOI":"10.1007\/s11033-026-11633-0"},{"key":"11789_CR13","doi-asserted-by":"publisher","unstructured":"Yang C, Yin Z, Yuan H, et al (2026) UHRF1 as an epigenetic therapeutic target in Cancer. Mol Biol Rep 53:454. https:\/\/doi.org\/10.1007\/s11033-026-11611-6","DOI":"10.1007\/s11033-026-11611-6"},{"key":"11789_CR14","first-page":"i2","volume":"7","author":"R Peterson","year":"2025","unstructured":"Peterson R, Cote DJ, Zada G (2025) Current understanding of the role of DNA methylation in pituitary neuroendocrine tumors. Neurooncol Adv 7:i2\u2013i9","journal-title":"Neurooncol Adv"},{"key":"11789_CR15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/path.833","volume":"193","author":"N Seemann","year":"2001","unstructured":"Seemann N, Kuhn D, Wrocklage C, Keyvani K, Hackl W, Buchfelder M, Fahlbusch R, Paulus W (2001) CDKN2A\/p16 inactivation is related to pituitary adenoma type and size. J Pathol 193:491\u2013497","journal-title":"J Pathol"},{"key":"11789_CR16","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.bcp.2004.04.030","volume":"68","author":"M Szyf","year":"2004","unstructured":"Szyf M, Pakneshan P, Rabbani SA (2004) DNA methylation and breast cancer. Biochem Pharmacol 68:1187\u20131197","journal-title":"Biochem Pharmacol"},{"key":"11789_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00381-026-07224-w","volume":"42","author":"Y Wang","year":"2026","unstructured":"Wang Y, Chen Y, Wei J, Chen L, Wei W, Li L, Jiang M, Hu T, Wang C, Wang Y, Zhang C (2026) Frontotemporal-orbitozygomatic approach for pediatric cranio-orbital tumors: a single-center experience. Child\u2019s Nerv Syst 42:129","journal-title":"Child\u2019s Nerv Syst"},{"key":"11789_CR18","first-page":"1262","volume":"87","author":"X Zhang","year":"2002","unstructured":"Zhang X, Sun H, Danila DC, Johnson SR, Zhou Y, Swearingen B, Klibanski A (2002) Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. J Clin Endocrinol Metab 87:1262\u20131267","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR19","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1210\/jc.2004-1848","volume":"90","author":"J Zhao","year":"2005","unstructured":"Zhao J, Dahle D, Zhou Y, Zhang X, Klibanski A (2005) Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. J Clin Endocrinol Metab 90:2179\u20132186","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR20","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.2353\/ajpath.2007.061111","volume":"170","author":"X Zhu","year":"2007","unstructured":"Zhu X, Lee K, Asa SL, Ezzat S (2007) Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells. Am J Pathol 170:1618\u20131628","journal-title":"Am J Pathol"},{"key":"11789_CR21","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s12022-021-09702-0","volume":"33","author":"H Alzoubi","year":"2022","unstructured":"Alzoubi H, Minasi S, Gianno F, Antonelli M, Belardinilli F, Giangaspero F, Jaffrain-Rea ML, Buttarelli FR (2022) Alternative Lengthening of Telomeres (ALT) and Telomerase Reverse Transcriptase Promoter Methylation in Recurrent Adult and Primary Pediatric Pituitary Neuroendocrine Tumors. Endocr Pathol 33:494\u2013505","journal-title":"Endocr Pathol"},{"key":"11789_CR22","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1093\/neuonc\/noaf109","volume":"27","author":"S Belakhoua","year":"2025","unstructured":"Belakhoua S, Vasudevaraja V, Schroff C, Galbraith K, Movahed-Ezazi M, Serrano J, Yang Y, Orringer D, Golfinos JG, Sen C, Pacione D, Agrawal N, Snuderl M (2025) DNA methylation profiling of pituitary neuroendocrine tumors identifies distinct clinical and pathological subtypes based on epigenetic differentiation. Neuro Oncol 27:2341\u20132354","journal-title":"Neuro Oncol"},{"key":"11789_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12022-025-09896-7","volume":"37","author":"F Carbonara","year":"2026","unstructured":"Carbonara F, Gianno F, Feola T, Mancinelli F, De Alcubierre D, Moroni M, Lucantonio E, Arcella A, Di Pardo A, Morace R, Isidori AM, Gambardella S, Esposito V (2026) Jaffrain-Rea, New Insights from the Expression of the Mismatch Repair System in Pituitary Neuroendocrine Tumors. Endocr Pathol 37:2","journal-title":"Endocr Pathol"},{"key":"11789_CR24","doi-asserted-by":"crossref","unstructured":"Dalakas K, Engstr\u00f6m BE, Tebani A, Bontell TO, Larsson A, Nord H, Lindskog C, Pont\u00e9n F, Boldt HB, Ragnarsson O (2026) Casar-Borota, Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients. Acta Neuropathol Commun, 14","DOI":"10.1186\/s40478-026-02225-x"},{"key":"11789_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12022-025-09879-8","volume":"36","author":"M Dottermusch","year":"2025","unstructured":"Dottermusch M (2025) Pituitary Neuroendocrine Tumor or Pituitary Adenoma? Let\u2019s Ask the Epigenome! Endocr Pathol 36:35","journal-title":"Endocr Pathol"},{"key":"11789_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6\u201321","journal-title":"Genes Dev"},{"key":"11789_CR27","doi-asserted-by":"publisher","first-page":"596554","DOI":"10.3389\/fendo.2020.596554","volume":"11","author":"M Chang","year":"2020","unstructured":"Chang M, Yang C, Bao X, Wang R (2020) Genetic and Epigenetic Causes of Pituitary Adenomas. Front Endocrinol (Lausanne) 11:596554","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11789_CR28","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/cen.14827","volume":"97","author":"F Guaraldi","year":"2022","unstructured":"Guaraldi F, Morandi L, Zoli M, Mazzatenta D, Righi A, Evangelisti S, Ambrosi F, Tonon C, Giannini C, Lloyd RV, Asioli S (2022) Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients. Clin Endocrinol (Oxf) 97:763\u2013772","journal-title":"Clin Endocrinol (Oxf)"},{"key":"11789_CR29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of Cancer: New Dimensions. Cancer Discov 12:31\u201346","journal-title":"Cancer Discov"},{"key":"11789_CR30","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMra023075","volume":"349","author":"JG Herman","year":"2003","unstructured":"Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042\u20132054","journal-title":"N Engl J Med"},{"key":"11789_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","volume":"31","author":"RJ Klose","year":"2006","unstructured":"Klose RJ, Bird AP (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31:89\u201397","journal-title":"Trends Biochem Sci"},{"key":"11789_CR32","doi-asserted-by":"publisher","first-page":"e96178","DOI":"10.1371\/journal.pone.0096178","volume":"9","author":"C Ling","year":"2014","unstructured":"Ling C, Pease M, Shi L, Punj V, Shiroishi MS, Commins D, Weisenberger DJ, Wang K, Zada G (2014) A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype. PLoS ONE 9:e96178","journal-title":"PLoS ONE"},{"key":"11789_CR33","doi-asserted-by":"publisher","unstructured":"M\u00f8ller MW, Nortvig MJ, Andersen MS, Poulsen FR  (2025) DNA Methylation in Pituitary Adenomas: A Scoping Review. Int J Mol Sci 26(2):531. https:\/\/doi.org\/10.3390\/ijms26020531","DOI":"10.3390\/ijms26020531"},{"key":"11789_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/npp.2012.112","volume":"38","author":"LD Moore","year":"2013","unstructured":"Moore LD, Le T, Fan G (2013) DNA methylation and its basic function. Neuropsychopharmacology 38:23\u201338","journal-title":"Neuropsychopharmacology"},{"key":"11789_CR35","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1093\/neuonc\/noab044","volume":"23","author":"MS Mosella","year":"2021","unstructured":"Mosella MS, Sabedot TS, Silva TC, Malta TM, Dezem FS, Asmaro KP, Wells M, Mukherjee A, Poisson LM, Snyder J, deCarvalho AC, Walbert T, Aho T, Kalkanis S, Elias PC, Antonini SR, Rock J, Noushmehr H, Castro M, Castro AV (2021) DNA methylation-based signatures classify sporadic pituitary tumors according to clinicopathological features. Neuro Oncol 23:1292\u20131303","journal-title":"Neuro Oncol"},{"key":"11789_CR36","doi-asserted-by":"crossref","unstructured":"Neou M, Villa C, Armignacco R, Jouinot A, Raffin-Sanson ML, Septier A, Letourneur F, Diry S, Diedisheim M, Izac B, Gaspar C, Perlemoine K, Verjus V, Bernier M, Boulin A, Emile JF, Bertagna X, Jaffrezic F, Laloe D, Baussart B, Bertherat J, Gaillard S, Assi\u00e9 G (2020) Pangenomic Classification of Pituitary Neuroendocrine Tumors, Cancer Cell, 37 123\u2013134.e125","DOI":"10.1016\/j.ccell.2019.11.002"},{"key":"11789_CR37","doi-asserted-by":"crossref","unstructured":"Arya S, Kumari B, Khare R, Garg I, Pacherwal P, Joshi RK, Kumar R, Srivastava S (2026) Epigenetic insights into high-altitude-induced venous thromboembolism: methylation signatures in Indian population. Mol Biol Rep, 53","DOI":"10.1007\/s11033-026-11554-y"},{"key":"11789_CR38","doi-asserted-by":"crossref","unstructured":"\u00c7elikezen F, Arslan ME, Firat M, Hacimuftuoglu A, Abd El-Aty AM, Seyhan E, Turkez H (2026) Neuroprotective potential of Bilacunaria microcarpa extracts in Mpp+ induced SH-SY5Y cell model of Parkinson\u2019s disease. Mol Biol Rep, 53","DOI":"10.1007\/s11033-026-11677-2"},{"key":"11789_CR39","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/s41467-019-10176-2","volume":"10","author":"J Zhou","year":"2019","unstructured":"Zhou J, Huang S, Wang Z, Huang J, Xu L, Tang X, Wan YY, Li QJ, Symonds ALJ, Long H, Zhu B (2019) Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. Nat Commun 10:2427","journal-title":"Nat Commun"},{"key":"11789_CR40","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1002\/jcp.25401","volume":"231","author":"A Roostaee","year":"2016","unstructured":"Roostaee A, Benoit YD, Boudjadi S, Beaulieu JF (2016) Epigenetics in Intestinal Epithelial Cell Renewal. J Cell Physiol 231:2361\u20132367","journal-title":"J Cell Physiol"},{"key":"11789_CR41","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1038\/s41467-024-46637-6","volume":"15","author":"VS Frisbie","year":"2024","unstructured":"Frisbie VS, Hashimoto H, Xie Y, De Luna Vitorino FN, Baeza J, Nguyen T, Yuan Z, Kiselar J, Garcia BA, Debler EW (2024) Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids. Nat Commun 15:2467","journal-title":"Nat Commun"},{"key":"11789_CR42","doi-asserted-by":"crossref","unstructured":"Valencia-S\u00e1nchez MI, De Ioannes P, Wang M, Truong DM, Lee R, Armache JP, Boeke JD, Armache KJ (2021) Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation. Science, 371","DOI":"10.1126\/science.abc6663"},{"key":"11789_CR43","doi-asserted-by":"crossref","unstructured":"Worden EJ, Hoffmann NA, Hicks CW, Wolberger C (2019) Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell 176:1490\u20131501e1412","DOI":"10.1016\/j.cell.2019.02.002"},{"key":"11789_CR44","doi-asserted-by":"crossref","unstructured":"E.S. Lander, L.M. Linton, B. Birren, C. Nusbaum, M.C. Zody, J. Baldwin, K. Devon,K. Dewar, M. Doyle, W. FitzHugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland,L. Kann, J. Lehoczky, R. LeVine, P. McEwan, K. McKernan, J. Meldrim, J.P. Mesirov,C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan,C. Sougnez, Y. Stange-Thomann, N. Stojanovic, A. Subramanian, D. Wyman, J. Rogers,J. Sulston, R. Ainscough, S. Beck, D. Bentley, J. Burton, C. Clee, N. Carter, A. Coulson,R. Deadman, P. Deloukas, A. Dunham, I. Dunham, R. Durbin, L. French, D. Grafham, S.Gregory, T. Hubbard, S. Humphray, A. Hunt, M. Jones, C. Lloyd, A. McMurray, L. Matthews,S. Mercer, S. Milne, J.C. Mullikin, A. Mungall, R. Plumb, M. Ross, R. Shownkeen, S.Sims, R.H. Waterston, R.K. Wilson, L.W. Hillier, J.D. McPherson, M.A. Marra, E.R.Mardis, L.A. Fulton, A.T. Chinwalla, K.H. Pepin, W.R. Gish, S.L. Chissoe, M.C. Wendl,K.D. Delehaunty, T.L. Miner, A. Delehaunty, J.B. Kramer, L.L. Cook, R.S. Fulton, D.L.Johnson, P.J. Minx, S.W. Clifton, T. Hawkins, E. Branscomb, P. Predki, P. Richardson,S. Wenning, T. Slezak, N. Doggett, J.F. Cheng, A. Olsen, S. Lucas, C. Elkin, E. Uberbacher,M. Frazier, R.A. Gibbs, D.M. Muzny, S.E. Scherer, J.B. Bouck, E.J. Sodergren, K.C.Worley, C.M. Rives, J.H. Gorrell, M.L. Metzker, S.L. Naylor, R.S. Kucherlapati, D.L.Nelson, G.M. Weinstock, Y. Sakaki, A. Fujiyama, M. Hattori, T. Yada, A. Toyoda, T.Itoh, C. Kawagoe, H. Watanabe, Y. Totoki, T. Taylor, J. Weissenbach, R. Heilig, W.Saurin, F. Artiguenave, P. Brottier, T. Bruls, E. Pelletier, C. Robert, P. Wincker,D.R. Smith, L. Doucette-Stamm, M. Rubenfield, K. Weinstock, H.M. Lee, J. Dubois, A.Rosenthal, M. Platzer, G. Nyakatura, S. Taudien, A. Rump, H. Yang, J. Yu, J. Wang,G. Huang, J. Gu, L. Hood, L. Rowen, A. Madan, S. Qin, R.W. Davis, N.A. Federspiel,A.P. Abola, M.J. Proctor, R.M. Myers, J. Schmutz, M. Dickson, J. Grimwood, D.R. Cox,M.V. Olson, R. Kaul, C. Raymond, N. Shimizu, K. Kawasaki, S. Minoshima, G.A. Evans,M. Athanasiou, R. Schultz, B.A. Roe, F. Chen, H. Pan, J. Ramser, H. Lehrach, R. Reinhardt,W.R. McCombie, M. de la Bastide, N. Dedhia, H. Bl\u00f6cker, K. Hornischer, G. Nordsiek,R. Agarwala, L. Aravind, J.A. Bailey, A. Bateman, S. Batzoglou, E. Birney, P. Bork,D.G. Brown, C.B. Burge, L. Cerutti, H.C. Chen, D. Church, M. Clamp, R.R. Copley, T.Doerks, S.R. Eddy, E.E. Eichler, T.S. Furey, J. Galagan, J.G. Gilbert, C. Harmon,Y. Hayashizaki, D. Haussler, H. Hermjakob, K. Hokamp, W. Jang, L.S. Johnson, T.A.Jones, S. Kasif, A. Kaspryzk, S. Kennedy, W.J. Kent, P. Kitts, E.V. Koonin, I. Korf,D. Kulp, D. Lancet, T.M. Lowe, A. McLysaght, T. Mikkelsen, J.V. Moran, N. Mulder,V.J. Pollara, C.P. Ponting, G. Schuler, J. Schultz, G. Slater, A.F. Smit, E. Stupka,J. Szustakowki, D. Thierry-Mieg, J. Thierry-Mieg, L. Wagner, J. Wallis, R. Wheeler,A. Williams, Y.I. Wolf, K.H. Wolfe, S.P. Yang, R.F. Yeh, F. Collins, M.S. Guyer, J.Peterson, A. Felsenfeld, K.A. Wetterstrand, A. Patrinos, M.J. Morgan, P. de Jong,J.J. Catanese, K. Osoegawa, H. Shizuya, S. Choi, Y.J. Chen, J. Szustakowki, Initial sequencing and analysis of the human genome, Nature, 409 (2001) 860\u2013921","DOI":"10.1038\/35057062"},{"key":"11789_CR45","doi-asserted-by":"publisher","first-page":"E7526","DOI":"10.1073\/pnas.1703087114","volume":"114","author":"DM Jeziorska","year":"2017","unstructured":"Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch M, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C (2017) DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proc Natl Acad Sci U S A 114:E7526\u2013e7535","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11789_CR46","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/35106079","volume":"1","author":"P Marks","year":"2001","unstructured":"Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK (2001) Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1:194\u2013202","journal-title":"Nat Rev Cancer"},{"key":"11789_CR47","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nrg1349","volume":"5","author":"MJ Fazzari","year":"2004","unstructured":"Fazzari MJ, Greally JM (2004) Epigenomics: beyond CpG islands. Nat Rev Genet 5:446\u2013455","journal-title":"Nat Rev Genet"},{"key":"11789_CR48","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1038\/sj.onc.1205597","volume":"21","author":"PA Jones","year":"2002","unstructured":"Jones PA (2002) DNA methylation and cancer. Oncogene 21:5358\u20135360","journal-title":"Oncogene"},{"key":"11789_CR49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrg.2017.33","volume":"18","author":"X Wu","year":"2017","unstructured":"Wu X, Zhang Y (2017) TET-mediated active DNA demethylation: mechanism, function and beyond. Nat Rev Genet 18:517\u2013534","journal-title":"Nat Rev Genet"},{"key":"11789_CR50","doi-asserted-by":"publisher","first-page":"12418","DOI":"10.1038\/ncomms12418","volume":"7","author":"CM Greco","year":"2016","unstructured":"Greco CM, Kunderfranco P, Rubino M, Larcher V, Carullo P, Anselmo A, Kurz K, Carell T, Angius A, Latronico MV, Papait R, Condorelli G (2016) DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy. Nat Commun 7:12418","journal-title":"Nat Commun"},{"key":"11789_CR51","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41576-020-00311-x","volume":"22","author":"EZ Kvon","year":"2021","unstructured":"Kvon EZ, Waymack R, Gad M, Wunderlich Z (2021) Enhancer redundancy in development and disease. Nat Rev Genet 22:324\u2013336","journal-title":"Nat Rev Genet"},{"key":"11789_CR52","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cr.2011.22","volume":"21","author":"AJ Bannister","year":"2011","unstructured":"Bannister AJ, Kouzarides T (2011) Regulation of chromatin by histone modifications. Cell Res 21:381\u2013395","journal-title":"Cell Res"},{"key":"11789_CR53","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/s41594-019-0309-8","volume":"26","author":"N Zaware","year":"2019","unstructured":"Zaware N, Zhou MM (2019) Bromodomain biology and drug discovery. Nat Struct Mol Biol 26:870\u2013879","journal-title":"Nat Struct Mol Biol"},{"key":"11789_CR54","doi-asserted-by":"crossref","unstructured":"Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135:1201\u20131212","DOI":"10.1016\/j.cell.2008.11.042"},{"key":"11789_CR55","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/sj.onc.1210855","volume":"27","author":"M Achour","year":"2008","unstructured":"Achour M, Jacq X, Rond\u00e9 P, Alhosin M, Charlot C, Chataigneau T, Jeanblanc M, Macaluso M, Giordano A, Hughes AD, Schini-Kerth VB, Bronner C (2008) The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene 27:2187\u20132197","journal-title":"Oncogene"},{"key":"11789_CR56","doi-asserted-by":"publisher","first-page":"7258","DOI":"10.1158\/0008-5472.CAN-08-0344","volume":"68","author":"EC Lopes","year":"2008","unstructured":"Lopes EC, Valls E, Figueroa ME, Mazur A, Meng FG, Chiosis G, Laird PW, Schreiber-Agus N, Greally JM, Prokhortchouk E, Melnick A (2008) Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res 68:7258\u20137263","journal-title":"Cancer Res"},{"key":"11789_CR57","doi-asserted-by":"publisher","first-page":"9883","DOI":"10.1073\/pnas.1817703116","volume":"116","author":"Y Wei","year":"2019","unstructured":"Wei Y, Lang J, Zhang Q, Yang CR, Zhao ZA, Zhang Y, Du Y, Sun Y (2019) DNA methylation analysis and editing in single mammalian oocytes. Proc Natl Acad Sci U S A 116:9883\u20139892","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11789_CR58","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41422-019-0230-z","volume":"29","author":"L Malbec","year":"2019","unstructured":"Malbec L, Zhang T, Chen YS, Zhang Y, Sun BF, Shi BY, Zhao YL, Yang Y, Yang YG (2019) Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation. Cell Res 29:927\u2013941","journal-title":"Cell Res"},{"key":"11789_CR59","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1261\/rna.047910.114","volume":"21","author":"S Haag","year":"2015","unstructured":"Haag S, Kretschmer J, Bohnsack MT (2015) WBSCR22\/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA. RNA 21:180\u2013187","journal-title":"RNA"},{"key":"11789_CR60","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/j.molcel.2019.03.040","volume":"74","author":"L Pandolfini","year":"2019","unstructured":"Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d\u2019Onofrio M, Balasubramanian S, Kouzarides T (2019) METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell 74:1278\u20131290e1279","journal-title":"Mol Cell"},{"key":"11789_CR61","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/255033a0","volume":"255","author":"S Muthukrishnan","year":"1975","unstructured":"Muthukrishnan S, Both GW, Furuichi Y, Shatkin AJ (1975) 5\u2019-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation. Nature 255:33\u201337","journal-title":"Nature"},{"key":"11789_CR62","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1186\/s12967-024-05771-x","volume":"22","author":"G Zhang","year":"2024","unstructured":"Zhang G, Cheng C, Wang X, Wang S (2024) N6-Methyladenosine methylation modification in breast cancer: current insights. J Transl Med 22:971","journal-title":"J Transl Med"},{"key":"11789_CR63","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1016\/j.molcel.2023.06.021","volume":"83","author":"I Loedige","year":"2023","unstructured":"Loedige I, Baranovskii A, Mendonsa S, Dantsuji S, Popitsch N, Breimann L, Zerna N, Cherepanov V, Milek M, Ameres S, Chekulaeva M (2023) mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons. Mol Cell 83:2709\u20132725e2710","journal-title":"Mol Cell"},{"key":"11789_CR64","doi-asserted-by":"crossref","unstructured":"Newey PJ, Thakker RV (2011) Role of multiple endocrine neoplasia type 1 mutational analysis in clinical practice. Endocr Pract 17(Suppl 3):8\u201317","DOI":"10.4158\/EP10379.RA"},{"key":"11789_CR65","doi-asserted-by":"crossref","unstructured":"Fleseriu M, Gurnell M, McCormack A, Fukuoka H, Glezer A, Langlois F, Schwartz TH, Greenman Y, Agrawal N, Akirov A, Bancos I, Capatina C, Castinetti F, Catalino M, Christ-Crain M, Das L, Drincic A, Freda PU, Gadelha MR, Giustina A, Hanzu F, Ho KKY, Isand K, Mallea-Gil S, Mamelak AN, Marcus HJ, Uygur MM, Molitch M, Nachtigall LB, Nowak E, Pereira AM, Pineyro MM, Shafiq I, Syro L, Takahashi Y, Varlamov EV, Vila G, Zada G, Karavitaki N, Melmed S (2025) Pituitary incidentaloma: a Pituitary Society international consensus guideline statement. Nat Rev Endocrinol 21:638\u2013655","DOI":"10.1038\/s41574-025-01134-8"},{"issue":"Suppl 3","key":"11789_CR66","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2176\/nmc.ra.2014-0184","volume":"54","author":"H Fukuoka","year":"2014","unstructured":"Fukuoka H, Takahashi Y (2014) The role of genetic and epigenetic changes in pituitary tumorigenesis. Neurol Med Chir (Tokyo) 54(Suppl 3):943\u2013957","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"11789_CR67","doi-asserted-by":"publisher","unstructured":"Fukuoka H, Shichi H, Yamamoto M, Takahashi Y (2020) The Mechanisms Underlying Autonomous Adrenocorticotropic Hormone Secretion in Cushing's Disease. Int J Mol Sci 21(23):9132. https:\/\/doi.org\/10.3390\/ijms21239132","DOI":"10.3390\/ijms21239132"},{"key":"11789_CR68","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00401-024-02686-1","volume":"147","author":"M Dottermusch","year":"2024","unstructured":"Dottermusch M, Ryba A, Ricklefs FL, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann JE, Sch\u00fcller U (2024) Pituitary neuroendocrine tumors with PIT1\/SF1 co-expression show distinct clinicopathological and molecular features. Acta Neuropathol 147:16","journal-title":"Acta Neuropathol"},{"key":"11789_CR69","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1210\/jc.2018-01856","volume":"104","author":"A Garc\u00eda-Mart\u00ednez","year":"2019","unstructured":"Garc\u00eda-Mart\u00ednez A, Sottile J, S\u00e1nchez-Tejada L, Fajardo C, C\u00e1mara R, Lamas C, Barber\u00e1 VM, Pic\u00f3 A (2019) DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors. J Clin Endocrinol Metab 104:1272\u20131282","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR70","doi-asserted-by":"publisher","first-page":"e1195","DOI":"10.1210\/clinem\/dgaf650","volume":"111","author":"A Haydar Ali Tajuddin","year":"2026","unstructured":"Haydar Ali Tajuddin A, Isa NF, Mohd Nasir MH (2026) Biomarkers Driving Precision Medicine in Nonfunctioning Pituitary Neuroendocrine Tumors: A Systematic Review of Recent Literature. J Clin Endocrinol Metab 111:e1195\u2013e1204","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR71","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1093\/neuonc\/noac050","volume":"24","author":"GA Herrgott","year":"2022","unstructured":"Herrgott GA, Asmaro KP, Wells M, Sabedot TS, Malta TM, Mosella MS, Nelson K, Scarpace L, Barnholtz-Sloan JS, Sloan AE, Selman WR, deCarvalho AC, Poisson LM, Mukherjee A, Robin AM, Lee IY, Snyder J, Walbert T, Rosenblum M, Mikkelsen T, Bhan A, Craig J, Kalkanis S, Rock J, Noushmehr H, Castro AV (2022) Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors. Neuro Oncol 24:1126\u20131139","journal-title":"Neuro Oncol"},{"key":"11789_CR72","doi-asserted-by":"crossref","unstructured":"Jotanovic J, Boldt HB, Burton M, Andersen MS, Bengtsson D, Bontell TO, Ekman B, Engstr\u00f6m BE, Feldt-Rasmussen U, Heck A, Jakovcevic A, J\u00f8rgensen JOL, Kraljevic I, Kunicki J, Lindsay JR, Losa M, Loughrey PB, Maiter D, Maksymowicz M, Manojlovic-Gacic E, Pahnke J, Petersenn S, Petersson M, Popovic V, Ragnarsson O, Rasmussen K \u00c5, Reisz Z, Saeger W, Schalin-J\u00e4ntti C, Scheie D, Terreni MR, Tynninen O, Whitelaw B, Burman P, Casar-Borota O (2024) Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors. Acta Neuropathol 148:68","DOI":"10.1007\/s00401-024-02836-5"},{"key":"11789_CR73","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1055\/a-2633-8467","volume":"133","author":"S Kayacan","year":"2025","unstructured":"Kayacan S, Gazioglu N, Orhan C, Comunoglu N, Kadioglu P, Tanriover N, Uysal O, Kaya Dagistanli F, Ozturk M (2025) A Novel Gene Expression Profile and Combined Effects in the Pathogenesis of Adrenocorticotropic Hormone-Secreting Pituitary Neuroendocrine Tumors. Exp Clin Endocrinol Diabetes 133:371\u2013381","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"11789_CR74","doi-asserted-by":"crossref","unstructured":"Lobato EC, Lafranchi AF, Freitas-Castro F, Fagundes GFC, Sadikovic B, Lines KE, Almeida MQ (2026) Epigenetics and Disease Progression in Neuroendocrine Neoplasms. Endocr Rev","DOI":"10.1210\/endrev\/bnag005"},{"key":"11789_CR75","doi-asserted-by":"crossref","unstructured":"M\u00f8ller MW, Herrgott GA, Andersen MS, Halle B, Pedersen CB, Boldt HB, Petersen JK, Powell C, Castro AV, Poulsen FR (2025) DNA Methylation Profiling Predicts Post-Surgical Regrowth in SF1-lineage Nonfunctioning Pituitary Neuroendocrine Tumors. Neuro Oncol","DOI":"10.1093\/neuonc\/noaf269"},{"key":"11789_CR76","doi-asserted-by":"crossref","unstructured":"Pandit N, Wehbeh Y, Itani O, Kanakis D (2026) Transcription Factor-Based Classification of Pituitary Neuroendocrine Tumors: Practical Immunohistochemical Algorithms, Molecular Correlates, and Diagnostic Challenges in the 5th WHO Era. Int J Mol Sci, 27","DOI":"10.20944\/preprints202601.1233.v1"},{"key":"11789_CR77","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1055\/s-0034-1383566","volume":"46","author":"I Binse","year":"2014","unstructured":"Binse I, Ueberberg B, Sandalcioglu IE, Flitsch J, Luedecke DK, Mann K, Petersenn S (2014) Expression analysis of GADD45\u03b3, MEG3, and p8 in pituitary adenomas. Horm Metab Res 46:644\u2013650","journal-title":"Horm Metab Res"},{"key":"11789_CR78","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1210\/me.2004-0087","volume":"18","author":"A Bahar","year":"2004","unstructured":"Bahar A, Simpson DJ, Cutty SJ, Bicknell JE, Hoban PR, Holley S, Mourtada-Maarabouni M, Williams GT, Clayton RN, Farrell WE (2004) Isolation and characterization of a novel pituitary tumor apoptosis gene. Mol Endocrinol 18:1827\u20131839","journal-title":"Mol Endocrinol"},{"key":"11789_CR79","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1267\/ahc.25-00054","volume":"59","author":"S Kitazawa","year":"2026","unstructured":"Kitazawa S (2026) Why Does DNA Methylation Accumulate at CpG Loci? Sequential Analysis of Cdkn2a\/p16(Ink4a) Gene Methylation in a Rat Renal Tumor Model. Acta Histochem Cytochem 59:23\u201334","journal-title":"Acta Histochem Cytochem"},{"key":"11789_CR80","doi-asserted-by":"publisher","first-page":"1362278","DOI":"10.3389\/fendo.2024.1362278","volume":"15","author":"Y Feng","year":"2024","unstructured":"Feng Y, Zhang Z, Tang J, Chen Y, Hu D, Huang X, Li F (2024) Ferroptosis-related biomarkers for adamantinomatous craniopharyngioma treatment: conclusions from machine learning techniques. Front Endocrinol (Lausanne) 15:1362278","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11789_CR81","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000094262","volume":"35","author":"D Giacomini","year":"2006","unstructured":"Giacomini D, P\u00e1ez-Pereda M, Theodoropoulou M, Gerez J, Nagashima AC, Chervin A, Berner S, Labeur M, Refojo D, Renner U, Stalla GK, Arzt E (2006) Bone morphogenetic protein-4 control of pituitary pathophysiology. Front Horm Res 35:22\u201331","journal-title":"Front Horm Res"},{"key":"11789_CR82","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mce.2010.04.006","volume":"326","author":"M Labeur","year":"2010","unstructured":"Labeur M, P\u00e1ez-Pereda M, Haedo M, Arzt E, Stalla GK (2010) Pituitary tumors: cell type-specific roles for BMP-4. Mol Cell Endocrinol 326:85\u201388","journal-title":"Mol Cell Endocrinol"},{"key":"11789_CR83","first-page":"75","volume":"67","author":"F Otsuka","year":"2013","unstructured":"Otsuka F (2013) Multifunctional bone morphogenetic protein system in endocrinology. Acta Med Okayama 67:75\u201386","journal-title":"Acta Med Okayama"},{"key":"11789_CR84","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1073\/pnas.0237312100","volume":"100","author":"M Paez-Pereda","year":"2003","unstructured":"Paez-Pereda M, Giacomini D, Refojo D, Nagashima AC, Hopfner U, Grubler Y, Chervin A, Goldberg V, Goya R, Hentges ST, Low MJ, Holsboer F, Stalla GK, Arzt E (2003) Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad\/estrogen receptor crosstalk. Proc Natl Acad Sci U S A 100:1034\u20131039","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11789_CR85","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/EJE-19-0677","volume":"182","author":"GK Stalla","year":"2020","unstructured":"Stalla GK, Dimopoulou C, Jung-Sievers C, Arzt E, Paez Pereda M, Theodoropoulou M, Ciato D, Renner U, GEOFFREY HARRIS AWARD 2019 (2020) Translational research in pituitary tumours. Eur J Endocrinol 182:R1\u2013r13","journal-title":"Eur J Endocrinol"},{"key":"11789_CR86","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1210\/en.2012-1231","volume":"153","author":"K Yacqub-Usman","year":"2012","unstructured":"Yacqub-Usman K, Duong CV, Clayton RN, Farrell WE (2012) Epigenomic silencing of the BMP-4 gene in pituitary adenomas: a potential target for epidrug-induced re-expression. Endocrinology 153:3603\u20133612","journal-title":"Endocrinology"},{"key":"11789_CR87","doi-asserted-by":"crossref","unstructured":"Yacqub-Usman K, Duong CV, Clayton RN, Farrell WE (2013) Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. Endocrinology 154:1711\u20131721","DOI":"10.1210\/en.2013-1061"},{"key":"11789_CR88","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/jnen\/64.5.398","volume":"64","author":"A Ogino","year":"2005","unstructured":"Ogino A, Yoshino A, Katayama Y, Watanabe T, Ota T, Komine C, Yokoyama T, Fukushima T (2005) The p15(INK4b)\/p16(INK4a)\/RB1 pathway is frequently deregulated in human pituitary adenomas. J Neuropathol Exp Neurol 64:398\u2013403","journal-title":"J Neuropathol Exp Neurol"},{"key":"11789_CR89","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12022-019-09598-x","volume":"31","author":"D Metin-Armagan","year":"2020","unstructured":"Metin-Armagan D, Comunoglu N, Bulut G, Kadioglu P, Kameda H, Gazioglu N, Tanriover N, Ozturk M (2020) A Novel Expression Profile of Cell Cycle and DNA Repair Proteins in Nonfunctioning Pituitary Adenomas. Endocr Pathol 31:2\u201313","journal-title":"Endocr Pathol"},{"key":"11789_CR90","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000355624","volume":"98","author":"CV Duong","year":"2013","unstructured":"Duong CV, Yacqub-Usman K, Emes RD, Clayton RN, Farrell WE (2013) The EFEMP1 gene: a frequent target for epigenetic silencing in multiple human pituitary adenoma subtypes. Neuroendocrinology 98:200\u2013211","journal-title":"Neuroendocrinology"},{"key":"11789_CR91","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s11102-018-0862-x","volume":"21","author":"ASG Micko","year":"2018","unstructured":"Micko ASG, H\u00f6ftberger R, W\u00f6hrer A, Millesi M, Knosp E, Wolfsberger S (2018) MGMT assessment in pituitary adenomas: comparison of different immunohistochemistry fixation chemicals. Pituitary 21:266\u2013273","journal-title":"Pituitary"},{"key":"11789_CR92","doi-asserted-by":"publisher","first-page":"357","DOI":"10.5114\/fn.2020.102438","volume":"58","author":"P Witek","year":"2020","unstructured":"Witek P, Maksymowicz M, Szamotulska K, Pia\u015bcik A, Wojciechowska-Lu\u017aniak A, Stasiewicz A, Witek J, Zieli\u0144ski G (2020) MGMT expression in pituitary corticotroph adenomas and its relationship to clinical, pathological, and ultrastructural parameters in patients with Cushing\u2019s disease. Folia Neuropathol 58:357\u2013364","journal-title":"Folia Neuropathol"},{"key":"11789_CR93","doi-asserted-by":"publisher","unstructured":"Zhu B, Wang J, Qin L, et al (2018) FGFR2 gene polymorphism rs2981582 is associated with non-functioning pituitary adenomas in Chinese Han population: a case-control study. Biosci Rep 38(6):BSR20181081. https:\/\/doi.org\/10.1042\/bsr20181081","DOI":"10.1042\/bsr20181081"},{"key":"11789_CR94","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1210\/en.2012-1007","volume":"153","author":"MV Recouvreux","year":"2012","unstructured":"Recouvreux MV, Camilletti MA, Rifkin DB, Becu-Villalobos D, D\u00edaz-Torga G (2012) Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-\u03b21 (TGF-\u03b21). Endocrinology 153:3861\u20133871","journal-title":"Endocrinology"},{"key":"11789_CR95","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.1111\/jcmm.14297","volume":"23","author":"J Ren","year":"2019","unstructured":"Ren J, Gu C, Yang Y, Xue J, Sun Y, Jian F, Chen D, Bian L, Sun Q (2019) TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing\u2019s disease. J Cell Mol Med 23:4097\u20134110","journal-title":"J Cell Mol Med"},{"key":"11789_CR96","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/labinvest.3700248","volume":"85","author":"ZR Qian","year":"2005","unstructured":"Qian ZR, Sano T, Yoshimoto K, Yamada S, Ishizuka A, Mizusawa N, Horiguchi H, Hirokawa M, Asa SL (2005) Inactivation of RASSF1A tumor suppressor gene by aberrant promoter hypermethylation in human pituitary adenomas. Lab Invest 85:464\u2013473","journal-title":"Lab Invest"},{"key":"11789_CR97","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/modpathol.3800965","volume":"20","author":"ZR Qian","year":"2007","unstructured":"Qian ZR, Sano T, Yoshimoto K, Asa SL, Yamada S, Mizusawa N, Kudo E (2007) Tumor-specific downregulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas. Mod Pathol 20:1269\u20131277","journal-title":"Mod Pathol"},{"key":"11789_CR98","doi-asserted-by":"publisher","first-page":"17498","DOI":"10.1073\/pnas.0804810105","volume":"105","author":"V Chesnokova","year":"2008","unstructured":"Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S (2008) p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A 105:17498\u201317503","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11789_CR99","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1053\/j.anndiagpath.2004.10.002","volume":"9","author":"AG Neto","year":"2005","unstructured":"Neto AG, McCutcheon IE, Vang R, Spencer ML, Zhang W, Fuller GN (2005) Elevated expression of p21 (WAF1\/Cip1) in hormonally active pituitary adenomas. Ann Diagn Pathol 9:6\u201310","journal-title":"Ann Diagn Pathol"},{"key":"11789_CR100","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41586-025-08935-x","volume":"641","author":"D Chen","year":"2025","unstructured":"Chen D, Lu S, Huang K, Pearson JD, Pacal M, Peidis P, McCurdy S, Yu T, Sangwan M, Nguyen A, Monnier PP, Schramek D, Zhu L, Santamaria D, Barbacid M, Akeno N, Wikenheiser-Brokamp KA, Bremner R (2025) Cell cycle duration determines oncogenic transformation capacity. Nature 641:1309\u20131318","journal-title":"Nature"},{"key":"11789_CR101","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1080\/15384101.2017.1403682","volume":"17","author":"M Fedele","year":"2018","unstructured":"Fedele M, Paciello O, De Biase D, Monaco M, Chiappetta G, Vitiello M, Barbieri A, Rea D, Luciano A, Papparella S, Arra C, Fusco A (2018) HMGA2 cooperates with either p27(kip1) deficiency or Cdk4(R24C) mutation in pituitary tumorigenesis. Cell Cycle 17:580\u2013588","journal-title":"Cell Cycle"},{"key":"11789_CR102","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/bjc.1997.521","volume":"76","author":"H Ikeda","year":"1997","unstructured":"Ikeda H, Yoshimoto T, Shida N (1997) Molecular analysis of p21 and p27 genes in human pituitary adenomas. Br J Cancer 76:1119\u20131123","journal-title":"Br J Cancer"},{"key":"11789_CR103","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1385\/EP:12:2:181","volume":"12","author":"K Komatsubara","year":"2001","unstructured":"Komatsubara K, Tahara S, Umeoka K, Sanno N, Teramoto A, Osamura RY (2001) Immunohistochemical analysis of p27 (Kip1) in human pituitary glands and in various types of pituitary adenomas. Endocr Pathol 12:181\u2013188","journal-title":"Endocr Pathol"},{"key":"11789_CR104","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1055\/s-0042-118613","volume":"48","author":"CS Martins","year":"2016","unstructured":"Martins CS, Camargo RC, Saggioro FP, Neder L, Machado HR, Moreira AC, de Castro M (2016) P27\/CDKN1B Translational Regulators in Pituitary Tumorigenesis. Horm Metab Res 48:840\u2013846","journal-title":"Horm Metab Res"},{"key":"11789_CR105","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ando.2012.04.001","volume":"73","author":"NS Pellegata","year":"2012","unstructured":"Pellegata NS (2012) MENX Ann Endocrinol (Paris) 73:65\u201370","journal-title":"MENX Ann Endocrinol (Paris)"},{"key":"11789_CR106","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s11060-013-1349-2","volume":"116","author":"Y Xu","year":"2014","unstructured":"Xu Y, Wang Y, Ma G, Wang Q, Wei G (2014) CUL4A is overexpressed in human pituitary adenomas and regulates pituitary tumor cell proliferation. J Neurooncol 116:625\u2013632","journal-title":"J Neurooncol"},{"key":"11789_CR107","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00401-008-0388-9","volume":"116","author":"BW Scheithauer","year":"2008","unstructured":"Scheithauer BW, Kovacs K, Horvath E, Kim DS, Osamura RY, Ketterling RP, Lloyd RV, Kim OL (2008) Pituitary blastoma. Acta Neuropathol 116:657\u2013666","journal-title":"Acta Neuropathol"},{"key":"11789_CR108","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4132\/jptm.2021.08.31","volume":"56","author":"SJ Kum","year":"2022","unstructured":"Kum SJ, Lee HW, Kim SG, Park H, Hwang I, Kim SP (2022) Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas. J Pathol Transl Med 56:22\u201331","journal-title":"J Pathol Transl Med"},{"key":"11789_CR109","first-page":"1357","volume":"58","author":"IM Moldovan","year":"2017","unstructured":"Moldovan IM, \u015eu\u015fman S, P\u00eerlog R, Jianu EM, Leucu\u0163a DC, Melincovici CS, Cri\u015fan D, Florian I (2017) Molecular markers in the diagnosis of invasive pituitary adenomas - an immunohistochemistry study. Rom J Morphol Embryol 58:1357\u20131364","journal-title":"Rom J Morphol Embryol"},{"key":"11789_CR110","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1016\/j.humpath.2013.05.020","volume":"44","author":"A Righi","year":"2013","unstructured":"Righi A, Morandi L, Leonardi E, Farnedi A, Marucci G, Sisto A, Frank G, Faustini-Fustini M, Zoli M, Mazzatenta D, Agati R, Foschini MP (2013) Galectin-3 expression in pituitary adenomas as a marker of aggressive behavior. Hum Pathol 44:2400\u20132409","journal-title":"Hum Pathol"},{"key":"11789_CR111","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.21037\/gs-21-720","volume":"10","author":"B Sun","year":"2021","unstructured":"Sun B, Dai C, Zhao S, Dong H, Liu H, Li Y, Wang R, Kang J (2021) MicroRNA-30d target TIMP3 induces pituitary tumor cell growth and invasion. Gland Surg 10:3314\u20133323","journal-title":"Gland Surg"},{"key":"11789_CR112","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12031-015-0698-z","volume":"58","author":"B Sun","year":"2016","unstructured":"Sun B, Liu X, Yang Y, Dai C, Li Y, Jiao Y, Wei Z, Yao Y, Feng M, Bao X, Deng K, Wang N, Wang R (2016) The Clinical Utility of TIMP3 Expression in ACTH-Secreting Pituitary Tumor. J Mol Neurosci 58:137\u2013144","journal-title":"J Mol Neurosci"},{"key":"11789_CR113","doi-asserted-by":"publisher","first-page":"971","DOI":"10.24976\/Discov.Med.202436184.90","volume":"36","author":"Y Yang","year":"2024","unstructured":"Yang Y, Huang F, Wu X, Huang C, Li Y (2024) Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas. Discov Med 36:971\u2013980","journal-title":"Discov Med"},{"key":"11789_CR114","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0960-0760(92)90072-Q","volume":"43","author":"X Bertagna","year":"1992","unstructured":"Bertagna X (1992) Unrestrained production of proopiomelanocortin (POMC) and its peptide fragments by pituitary corticotroph adenomas in Cushing\u2019s disease. J Steroid Biochem Mol Biol 43:379\u2013384","journal-title":"J Steroid Biochem Mol Biol"},{"key":"11789_CR115","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mce.2016.12.029","volume":"443","author":"H Gao","year":"2017","unstructured":"Gao H, Xue Y, Cao L, Liu Q, Liu C, Shan X, Wang H, Gu Y, Zhang Y (2017) ESR1 and its antagonist fulvestrant in pituitary adenomas. Mol Cell Endocrinol 443:32\u201341","journal-title":"Mol Cell Endocrinol"},{"key":"11789_CR116","doi-asserted-by":"publisher","first-page":"577","DOI":"10.4103\/neuroindia.NI_330_17","volume":"65","author":"M Shaid","year":"2017","unstructured":"Shaid M, Korbonits M (2017) Genetics of pituitary adenomas. Neurol India 65:577\u2013587","journal-title":"Neurol India"},{"key":"11789_CR117","volume-title":"GeneReviews(\u00ae), University of Washington, Seattle Copyright \u00a9 1993\u20132025, University of Washington, Seattle","author":"M Korbonits","year":"1993","unstructured":"Korbonits M, Hern\u00e1ndez-Ram\u00edrez LC (1993) AIP Familial Isolated Pituitary Adenomas. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A (eds) GeneReviews(\u00ae), University of Washington, Seattle Copyright \u00a9 1993\u20132025, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved., Seattle (WA)"},{"key":"11789_CR118","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3803\/EnM.2019.34.3.314","volume":"34","author":"YH Kim","year":"2019","unstructured":"Kim YH, Kim JH (2019) Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas. Endocrinol Metab (Seoul) 34:314\u2013322","journal-title":"Endocrinol Metab (Seoul)"},{"key":"11789_CR119","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1053\/j.seminoncol.2018.09.002","volume":"45","author":"C Solinas","year":"2018","unstructured":"Solinas C, Porcu M, De Silva P, Musi M, Aspeslagh S, Scartozzi M, Willard-Gallo K, Mariotti S, Saba L (2018) Cancer immunotherapy-associated hypophysitis. Semin Oncol 45:181\u2013186","journal-title":"Semin Oncol"},{"key":"11789_CR120","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3171\/2019.12.JNS192435","volume":"134","author":"C Ashton","year":"2021","unstructured":"Ashton C, Rhie SK, Carmichael JD, Zada G (2021) Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma. J Neurosurg 134:787\u2013793","journal-title":"J Neurosurg"},{"key":"11789_CR121","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1677\/ERC-09-0008","volume":"16","author":"K Revill","year":"2009","unstructured":"Revill K, Dudley KJ, Clayton RN, McNicol AM, Farrell WE (2009) Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma. Endocr Relat Cancer 16:537\u2013548","journal-title":"Endocr Relat Cancer"},{"key":"11789_CR122","first-page":"1211","volume":"60","author":"DJ Simpson","year":"2000","unstructured":"Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE (2000) Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 60:1211\u20131216","journal-title":"Cancer Res"},{"key":"11789_CR123","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1530\/EJE-10-0245","volume":"163","author":"Y Tani","year":"2010","unstructured":"Tani Y, Inoshita N, Sugiyama T, Kato M, Yamada S, Shichiri M, Hirata Y (2010) Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas. Eur J Endocrinol 163:523\u2013529","journal-title":"Eur J Endocrinol"},{"key":"11789_CR124","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1530\/ERC-12-0251","volume":"19","author":"CV Duong","year":"2012","unstructured":"Duong CV, Emes RD, Wessely F, Yacqub-Usman K, Clayton RN, Farrell WE (2012) Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas. Endocr Relat Cancer 19:805\u2013816","journal-title":"Endocr Relat Cancer"},{"key":"11789_CR125","first-page":"51","volume":"114","author":"P Kober","year":"2024","unstructured":"Kober P, Rymuza J, Baluszek S, Maksymowicz M, Nyc A, Mossakowska BJ, Zieli\u0144ski G, Kunicki J, Bujko M (2024) DNA Methylation Pattern Somatotroph Pituit Neuroendocrine Tumors Neuroendocrinol 114:51\u201363","journal-title":"DNA Methylation Pattern Somatotroph Pituit Neuroendocrine Tumors Neuroendocrinol"},{"key":"11789_CR126","doi-asserted-by":"crossref","unstructured":"Jelena J, Henning B\u00fcnsow B, Mark B, Marianne Skovsager A, Daniel B, Thomas Olsson B, Bertil E, Britt Ed\u00e9n E, Ulla F-R, Ansgar H, Antonia J, Jens Otto J, Ivana LK, Jacek K, John L, Marco RL, Paul Benjamin L, Dominique M, Maria M, Emilija M-G, Jens P, Stephan P, Maria P, Vera P, Oskar R, \u00c5se R, Krogh R, Zita S, Wolfgang S-J, Camilla S, David T, Maria Rosa T, Olli W, Ben B, Pia, Olivera C-B (2024) Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors. Acta Neuropathol, 148","DOI":"10.1007\/s00401-024-02836-5"},{"key":"11789_CR127","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12022-025-09864-1","volume":"36","author":"T Rafiq","year":"2025","unstructured":"Rafiq T, Matschke J, Flitsch J, Dottermusch M (2025) Three Synchronous Pituitary Neuroendocrine Tumors-Epigenomics Confirm an Exceptional Triple PitNET. Endocr Pathol 36:19","journal-title":"Endocr Pathol"},{"key":"11789_CR128","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1186\/s12967-024-05736-0","volume":"22","author":"J Rymuza","year":"2024","unstructured":"Rymuza J, Kober P, Maksymowicz M, Nyc A, Mossakowska BJ, Woroniecka R, Ma\u0142awska N, Grygalewicz B, Baluszek S, Zieli\u0144ski G, Kunicki J, Bujko M (2024) High level of aneuploidy and recurrent loss of chromosome 11 as relevant features of somatotroph pituitary tumors. J Transl Med 22:994","journal-title":"J Transl Med"},{"key":"11789_CR129","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1210\/endrev\/bnaa006","volume":"41","author":"V Srirangam Nadhamuni","year":"2020","unstructured":"Srirangam Nadhamuni V, Korbonits M (2020) Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms. Endocr Rev 41:821\u2013846","journal-title":"Endocr Rev"},{"key":"11789_CR130","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1210\/clinem\/dgac496","volume":"107","author":"B Szab\u00f3","year":"2022","unstructured":"Szab\u00f3 B, N\u00e9meth K, M\u00e9sz\u00e1ros K, Krokker L, Lik\u00f3 I, Sask\u0151i \u00c9, N\u00e9meth K, Szab\u00f3 PT, Sz\u00fccs N, Czirj\u00e1k S, Szal\u00f3ki G, Pat\u00f3cs A (2022) Butz, Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma. J Clin Endocrinol Metab 107:3066\u20133079","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR131","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12967-015-0405-4","volume":"13","author":"AL Wong","year":"2015","unstructured":"Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M (2015) Goh, Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib. J Transl Med 13:57","journal-title":"J Transl Med"},{"key":"11789_CR132","first-page":"ii41","volume":"4","author":"EL Carpenter","year":"2022","unstructured":"Carpenter EL, Bagley SJ (2022) Clinical utility of plasma cell-free DNA in gliomas. Neurooncol Adv 4:ii41\u2013ii44","journal-title":"Neurooncol Adv"},{"key":"11789_CR133","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12935-021-01804-3","volume":"21","author":"H Xu","year":"2021","unstructured":"Xu H, Zhu Q, Tang L, Jiang J, Yuan H, Zhang A, Lou M (2021) Prognostic and predictive value of FCER1G in glioma outcomes and response to immunotherapy. Cancer Cell Int 21:103","journal-title":"Cancer Cell Int"},{"key":"11789_CR134","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41467-023-43743-9","volume":"15","author":"H Lv","year":"2024","unstructured":"Lv H, Zong Q, Chen C, Lv G, Xiang W, Xing F, Jiang G, Yan B, Sun X, Ma Y, Wang L, Wu Z, Cui X, Wang H, Yang W (2024) TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer. Nat Commun 15:6","journal-title":"Nat Commun"},{"key":"11789_CR135","doi-asserted-by":"publisher","first-page":"e13492","DOI":"10.1111\/jne.13492","volume":"37","author":"B Tsegaye","year":"2025","unstructured":"Tsegaye B, Kober P, Mossakowska BJ, Baluszek S, Maksymowicz M, Buchalska B, Kunicki J, Bujko M (2025) DNA hypomethylation-related expression of hsa-miR-184 contributes to invasive growth of gonadotroph neuroendocrine pituitary tumors. J Neuroendocrinol 37:e13492","journal-title":"J Neuroendocrinol"},{"key":"11789_CR136","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1210\/clinem\/dgab652","volume":"107","author":"M Chang","year":"2022","unstructured":"Chang M, Wang Z, Gao J, Yang C, Feng M, Niu Y, Tong WM, Bao X, Wang R (2022) METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas. J Clin Endocrinol Metab 107:136\u2013149","journal-title":"J Clin Endocrinol Metab"},{"key":"11789_CR137","doi-asserted-by":"publisher","first-page":"10024","DOI":"10.1158\/0008-5472.CAN-08-2208","volume":"68","author":"DP Harper","year":"2008","unstructured":"Harper DP, Aplan PD (2008) Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects. Cancer Res 68:10024\u201310027","journal-title":"Cancer Res"},{"key":"11789_CR138","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2007.05.042","volume":"130","author":"MG Guenther","year":"2007","unstructured":"Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA (2007) A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130:77\u201388","journal-title":"Cell"},{"key":"11789_CR139","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccr.2005.05.021","volume":"7","author":"GM Gutierrez","year":"2005","unstructured":"Gutierrez GM, Kong E, Hinds PW (2005) Master or slave: the complex relationship of RBP2 and pRb. Cancer Cell 7:501\u2013502","journal-title":"Cancer Cell"},{"key":"11789_CR140","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0092-8674(03)00360-X","volume":"113","author":"M Hampsey","year":"2003","unstructured":"Hampsey M, Reinberg D (2003) Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell 113:429\u2013432","journal-title":"Cell"},{"key":"11789_CR141","doi-asserted-by":"publisher","first-page":"101042831771179","DOI":"10.1177\/1010428317711794","volume":"39","author":"Y Xue","year":"2017","unstructured":"Xue Y, Chen R, Du W, Yang F, Wei X (2017) RIZ1 and histone methylation status in pituitary adenomas. Tumour Biol 39:1010428317711794","journal-title":"Tumour Biol"},{"key":"11789_CR142","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s40478-024-01796-x","volume":"12","author":"K Taniguchi-Ponciano","year":"2024","unstructured":"Taniguchi-Ponciano K, Hinojosa-Alvarez S, Hernandez-Perez J, Chavez-Santoscoy RA, Remba-Shapiro I, Guinto G, Magallon-Gayon E, Telles-Ramirez B, de Leon-Conconi RP, Vela-Pati\u00f1o S, Andonegui-Elguera S, Cano-Zaragoza A, Martinez-Mendoza F, Kerbel J, Loza-Mejia M, Rodrigo-Salazar J, Mendez-Perez A, Aguilar-Flores C, Chavez-Gonzalez A, Ortiz-Reyes E, Gomez-Apo E, Bonifaz LC, Marrero-Rodriguez D, Mercado M (2024) Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways. Acta Neuropathol Commun 12:142","journal-title":"Acta Neuropathol Commun"},{"key":"11789_CR143","doi-asserted-by":"publisher","first-page":"102039","DOI":"10.1016\/j.mcp.2025.102039","volume":"83","author":"N Wu","year":"2025","unstructured":"Wu N, Wu N, Wang N, Zhu Y (2025) Progress in the pathogenesis and treatment of pituitary neuroendocrine tumors (PitNETs): From molecular mechanisms to emerging therapies. Mol Cell Probes 83:102039","journal-title":"Mol Cell Probes"},{"key":"11789_CR144","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12935-026-04192-8","volume":"26","author":"S Yang","year":"2026","unstructured":"Yang S, Pu C, Deng C, Bai X, Tian C, Zhang W, Deng K, Duan L, Lu L, Zhu H, Yao Y, Wang R, Chang M, Feng M (2026) Single-cell and machine learning approaches reveal METTL14-mediated autophagy via PI3K\/AKT signaling in invasive PitNET. Cancer Cell Int 26:72","journal-title":"Cancer Cell Int"},{"key":"11789_CR145","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fendo.2020.00026","volume":"11","author":"X Zhan","year":"2020","unstructured":"Zhan X, Desiderio DM (2020) Editorial: Molecular Network Study of Pituitary Adenomas. Front Endocrinol (Lausanne) 11:26","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11789_CR146","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.5808\/gi.21078","volume":"20","author":"K Park","year":"2022","unstructured":"Park K, Jeon MC, Kim B, Cha B, Kim JI (2022) Experimental development of the epigenomic library construction method to elucidate the epigenetic diversity and causal relationship between epigenome and transcriptome at a single-cell level. Genomics Inf 20:e2","journal-title":"Genomics Inf"},{"key":"11789_CR147","doi-asserted-by":"publisher","first-page":"e071629","DOI":"10.1136\/bmjopen-2023-071629","volume":"13","author":"M Baquedano","year":"2023","unstructured":"Baquedano M, de Jesus SE, Rapetto F, Murphy GJ, Angelini G, Benedetto U, Caldas P, Srivastava PK, Uzun O, Luyt K, Gonzalez Corcia C, Taliotis D, Stoica S, Lawlor DA, Bamber AR, Perry A, Skeffington KL, Omeje I, Pappachan J, Mumford AD, Coward RJM, Kenny D, Caputo M (2023) Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre prospective cohort study (Children OMACp). BMJ Open 13:e071629","journal-title":"BMJ Open"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11789-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11789-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11789-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:02:16Z","timestamp":1775901736000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11789-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":147,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11789"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11789-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable (this is a review paper).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable (this is a review paper).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"608"}}