{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:03:57Z","timestamp":1777982637385,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Mission-IND project of the Council of Scientific and Industrial Research"},{"name":"Indo-French venture of \u201cJoint Laboratory for Natural Products and Synthesis towards Affordable Health"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11843-6","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:02:01Z","timestamp":1777374121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of a novel spirocyclic molecule in a murine model of peripheral nerve injury mediated via anti-inflammatory and neuroprotective properties"],"prefix":"10.1007","volume":"53","author":[{"given":"Soumya","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Papia","family":"Basuthakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincy","family":"Vijay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachyutharayalu","family":"Oja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Samineni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debiprasad","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratistha","family":"Wadnerkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srihari","family":"Pabbaraja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goverdhan","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumana","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"6","key":"11843_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/mus.27706","volume":"66","author":"LR Robinson","year":"2022","unstructured":"Robinson LR (2022) Traumatic injury to peripheral nerves. Muscle Nerve 66(6):661\u2013670","journal-title":"Muscle Nerve"},{"key":"11843_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bjps.2023.02.017","volume":"80","author":"RN Murphy","year":"2023","unstructured":"Murphy RN, de Schoulepnikoff C, Chen JH, Columb MO, Bedford J, Wong JK, Reid AJ (2023) The incidence and management of peripheral nerve injury in England (2005\u20132020). J Plast Reconstr Aesthetic Surg 80:75\u201385","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"11843_CR3","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.addr.2014.11.010","volume":"82","author":"A Faroni","year":"2015","unstructured":"Faroni A, Mobasseri SA, Kingham PJ, Reid AJ (2015) Peripheral nerve regeneration: experimental strategies and future perspectives. Adv Drug Deliv Rev 82:160\u2013167","journal-title":"Adv Drug Deliv Rev"},{"key":"11843_CR4","doi-asserted-by":"crossref","unstructured":"Thakur S, Kumar A, Dijkstra A, Thakur A (2024) Occupational therapy-based rehabilitation of sciatic nerve pain. Brain\u2010X, 2(4), e70010","DOI":"10.1002\/brx2.70010"},{"key":"11843_CR5","doi-asserted-by":"crossref","unstructured":"Ghosh S, Basuthakur P, Chakravarty S (2025) Peripheral Neuropathy: Pathophysiology, Challenges, and Therapeutic Insights. The Palgrave Encyclopedia of Disability.Cham: Springer Nature Switzerland , pp 1\u201321","DOI":"10.1007\/978-3-031-40858-8_239-1"},{"issue":"23","key":"11843_CR6","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.2106\/JBJS.L.00704","volume":"95","author":"JW Griffin","year":"2013","unstructured":"Griffin JW, Hogan MV, Chhabra AB, Deal DN (2013) Peripheral nerve repair and reconstruction. Jbjs 95(23):2144\u20132151","journal-title":"Jbjs"},{"key":"11843_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jneumeth.2014.01.020","volume":"227","author":"LE Savastano","year":"2014","unstructured":"Savastano LE, Laurito SR, Fitt MR, Rasmussen JA, Polo VG, Patterson SI (2014) Sciatic nerve injury: a simple and subtle model for investigating many aspects of nervous system damage and recovery. J Neurosci Methods 227:166\u2013180","journal-title":"J Neurosci Methods"},{"key":"11843_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jneumeth.2015.01.021","volume":"243","author":"S Geuna","year":"2015","unstructured":"Geuna S (2015) The sciatic nerve injury model in pre-clinical research. J Neurosci Methods 243:39\u201346","journal-title":"J Neurosci Methods"},{"issue":"1","key":"11843_CR9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3344\/kjp.2021.34.1.124","volume":"34","author":"H Fidanc\u0131","year":"2021","unstructured":"Fidanc\u0131 H, \u00d6zt\u00fcrk \u0130 (2021) The relationship between nerve conduction studies and neuropathic pain in sciatic nerve injury due to intramuscular injection. Korean J pain 34(1):124\u2013131","journal-title":"Korean J pain"},{"issue":"4","key":"11843_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/14712598.2019.1576630","volume":"19","author":"S Sayad-Fathi","year":"2019","unstructured":"Sayad-Fathi S, Nasiri E, Zaminy A (2019) Advances in stem cell treatment for sciatic nerve injury. Expert Opin Biol Ther 19(4):301\u2013311","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"11843_CR11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13287-024-03837-7","volume":"15","author":"GD Xin","year":"2024","unstructured":"Xin GD, Liu XY, Fan XD, Zhao GJ (2024) Exosomes repairment for sciatic nerve injury: a cell-free therapy. Stem Cell Res Ther 15(1):214","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"11843_CR12","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/cns.14060","volume":"29","author":"D Zhang","year":"2023","unstructured":"Zhang D, Jing B, Chen ZN, Li X, Shi HM, Zheng YC, Zhao GP (2023) Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway. CNS Neurosci Ther 29(4):1000\u20131011","journal-title":"CNS Neurosci Ther"},{"issue":"36","key":"11843_CR13","first-page":"3416","volume":"8","author":"S Ma","year":"2013","unstructured":"Ma S, Peng C, Wu S, Wu D, Gao C (2013) Sciatic nerve regeneration using a nerve growth factor-containing fibrin glue membrane. Neural regeneration Res 8(36):3416\u20133422","journal-title":"Neural regeneration Res"},{"issue":"1","key":"11843_CR14","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1038\/s41598-017-01297-z","volume":"7","author":"PC Joshi","year":"2017","unstructured":"Joshi PC, Samineni R, Bhattacharya D, Reddy BR, Veeraval L, Das T, Chakravarty S (2017) A 2-oxa-spiro [5.4] decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic. Sci Rep 7(1):1492","journal-title":"Sci Rep"},{"issue":"1","key":"11843_CR15","doi-asserted-by":"publisher","first-page":"14134","DOI":"10.1038\/srep14134","volume":"5","author":"S Chakravarty","year":"2015","unstructured":"Chakravarty S, Maitra S, Reddy RG, Das T, Jhelum P, Kootar S, Kumar A (2015) A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action. Sci Rep 5(1):14134","journal-title":"Sci Rep"},{"issue":"34","key":"11843_CR16","doi-asserted-by":"publisher","first-page":"6830","DOI":"10.1039\/c2ob26107c","volume":"10","author":"G Mehta","year":"2012","unstructured":"Mehta G, Samineni R, Srihari P, Reddy RG, Chakravarty S (2012) Diverted organic synthesis (DOS): accessing a new, natural product inspired, neurotrophically active scaffold through an intramolecular Pauson\u2013Khand reaction. Org Biomol Chem 10(34):6830\u20136833","journal-title":"Org Biomol Chem"},{"issue":"1","key":"11843_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jneumeth.2007.02.017","volume":"163","author":"AL Lu\u00eds","year":"2007","unstructured":"Lu\u00eds AL, Amado S, Geuna S, Rodrigues JM, Sim\u00f5es MJ, Santos JD, Maur\u00edcio AC (2007) Long-term functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp. J Neurosci Methods 163(1):92\u2013104","journal-title":"J Neurosci Methods"},{"key":"11843_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12038-016-9627-8","volume":"41","author":"BR Reddy","year":"2016","unstructured":"Reddy BR, Maitra S, Jhelum P, Kumar KP, Bagul PK, Kaur G, Chakravarty S (2016) Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats. J Biosci 41:407\u2013417","journal-title":"J Biosci"},{"key":"11843_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchemneu.2018.04.006","volume":"92","author":"AB Wahul","year":"2018","unstructured":"Wahul AB, Joshi PC, Kumar A, Chakravarty S (2018) Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in Bilateral Common Carotid Arterial occlusion (BCCAo) mouse model. J Chem Neuroanat 92:1\u201315","journal-title":"J Chem Neuroanat"},{"issue":"7","key":"11843_CR20","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1021\/acsabm.4c00252","volume":"7","author":"P Basuthakur","year":"2024","unstructured":"Basuthakur P, Roy A, Ghosh S, Vijay V, Sinha D, Radhakrishnan M, Chakravarty S (2024) Pro-angiogenic terbium hydroxide nanorods improve critical limb ischemia in part by amelioration of ischemia-induced endothelial injury. ACS Appl Bio Mater 7(7):4389\u20134405","journal-title":"ACS Appl Bio Mater"},{"key":"11843_CR21","doi-asserted-by":"publisher","first-page":"1295563","DOI":"10.3389\/fnins.2023.1295563","volume":"17","author":"M Mahdian","year":"2023","unstructured":"Mahdian M, Tabatabai TS, Abpeikar Z, Rezakhani L, Khazaei M (2023) Nerve regeneration using decellularized tissues: challenges and opportunities. Front NeuroSci 17:1295563","journal-title":"Front NeuroSci"},{"key":"11843_CR22","doi-asserted-by":"publisher","first-page":"863969","DOI":"10.3389\/fbioe.2022.863969","volume":"10","author":"A Sanchez Rezza","year":"2022","unstructured":"Sanchez Rezza A, Kulahci Y, Gorantla VS, Zor F, Drzeniek NM (2022) Implantable biomaterials for peripheral nerve regeneration\u2013technology trends and translational tribulations. Front Bioeng Biotechnol 10:863969","journal-title":"Front Bioeng Biotechnol"},{"key":"11843_CR23","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1007\/s12035-015-9196-0","volume":"53","author":"H Hou","year":"2016","unstructured":"Hou H, Zhang L, Ye Z, Li J, Lian Z, Chen C, Tang P (2016) Chitooligosaccharide inhibits scar formation and enhances functional recovery in a mouse model of sciatic nerve injury. Mol Neurobiol 53:2249\u20132257","journal-title":"Mol Neurobiol"},{"issue":"1","key":"11843_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1515\/tnsci-2022-0214","volume":"13","author":"Q Siwei","year":"2022","unstructured":"Siwei Q, Ma N, Wang W, Chen S, Wu Q, Li Y, Yang Z (2022) Construction and effect evaluation of different sciatic nerve injury models in rats. Translational Neurosci 13(1):38\u201351","journal-title":"Translational Neurosci"},{"issue":"1","key":"11843_CR25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/ana.20901","volume":"60","author":"DM Deshpande","year":"2006","unstructured":"Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Kerr DA (2006) Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 60(1):32\u201344","journal-title":"Ann Neurol"},{"issue":"4","key":"11843_CR26","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1172\/JCI44071","volume":"124","author":"M Lavasani","year":"2014","unstructured":"Lavasani M, Thompson SD, Pollett JB, Usas A, Lu A, Stolz DB, Huard J (2014) Human muscle\u2013derived stem\/progenitor cells promote functional murine peripheral nerve regeneration. J Clin Investig 124(4):1745\u20131756","journal-title":"J Clin Investig"},{"issue":"3","key":"11843_CR27","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3174\/ajnr.A1820","volume":"31","author":"ZS Yin","year":"2010","unstructured":"Yin ZS, Zhang H, Gao W (2010) Erythropoietin promotes functional recovery and enhances nerve regeneration after peripheral nerve injury in rats. Am J Neuroradiol 31(3):509\u2013515","journal-title":"Am J Neuroradiol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11843-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:02:07Z","timestamp":1777374127000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11843-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11843"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11843-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9110922\/v1","asserted-by":"object"}]},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"13 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All animal experiments were performed at the CSIR-CCMB animal facility in Hyderabad. Before conducting the experiments, the protocol was approved by the Institutional Animal Ethics Committee of CSIR\u2013Centre for Cellular and Molecular Biology [CCMB\/IAEC 105\/2022], under registration number 20\/GO\/RBi\/99\/CPCSEA. Experiments were conducted in strict adherence to the relevant ethical regulations and the Guidelines for the Care and Use of Laboratory Animals. Efforts were made to minimize animal use and distress.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}],"article-number":"681"}}