{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:32:32Z","timestamp":1777728752742,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007104","name":"Trakya \u00dcniversitesi","doi-asserted-by":"publisher","award":["T\u00dcBAP 2022\/154"],"award-info":[{"award-number":["T\u00dcBAP 2022\/154"]}],"id":[{"id":"10.13039\/501100007104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11861-4","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:53:00Z","timestamp":1777459980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of irisin on miRNA-associated changes in the PGC-1\u03b1\/FNDC5\/BDNF Axis in an in vitro model of MPP\u207a-induced Parkinson\u2019s disease"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6001-2862","authenticated-orcid":false,"given":"Tutku","family":"Karaba\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-5732","authenticated-orcid":false,"given":"Hilal","family":"Sancar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0693-3569","authenticated-orcid":false,"given":"Deniz","family":"\u015eumnulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-055X","authenticated-orcid":false,"given":"Lokman","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"40310423","key":"11861_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","volume":"20","author":"HR Morris","year":"2024","unstructured":"Morris HR, Spillantini MG, Sue CM, Williams-Gray CH (2024) The pathogenesis of Parkinson\u2019s disease. Lancet 20(40310423):293\u2013304. https:\/\/doi.org\/10.1016\/S0140-6736(23)01478-2","journal-title":"Lancet"},{"issue":"11","key":"11861_CR2","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1136\/jnnp-2023-332974","volume":"16","author":"M Langeskov-Christensen","year":"2024","unstructured":"Langeskov-Christensen M, Franz\u00e9n E, Gr\u00f8ndahl Hvid L, Dalgas U (2024) Exercise as medicine in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 16(11):1077\u20131088. https:\/\/doi.org\/10.1136\/jnnp-2023-332974","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"11861_CR3","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s00210-023-02726-9","volume":"397","author":"NH Ali","year":"2024","unstructured":"Ali NH, Alhamdan NA, Al-Kuraishy HM, Al-Gareeb AI, Elekhnawy E, Batiha GE (2024) Irisin\/PGC-1\u03b1\/FNDC5 pathway in Parkinson\u2019s disease: truth under the throes. Naunyn Schmiedebergs Arch Pharmacol 397(4):1985\u20131995. https:\/\/doi.org\/10.1007\/s00210-023-02726-9","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"8","key":"11861_CR4","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s11011-024-01412","volume":"39","author":"RAL De Sousa","year":"2024","unstructured":"De Sousa RAL (2024) Exercise-produced irisin effects on brain-related pathological conditions. Metab Brain Dis 39(8):1679\u20131687. https:\/\/doi.org\/10.1007\/s11011-024-01412","journal-title":"Metab Brain Dis"},{"key":"11861_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13578-020-00413-3","volume":"10","author":"F Rabiee","year":"2020","unstructured":"Rabiee F, Lachinani L, Ghaedi S, Nasr-Esfahani MH, Megraw TL, Ghaedi K (2020) New insights into the cellular activities of Fndc5\/Irisin and its signaling pathways. Cell Biosci 10:51. https:\/\/doi.org\/10.1186\/s13578-020-00413-3","journal-title":"Cell Biosci"},{"key":"11861_CR6","doi-asserted-by":"publisher","unstructured":"Wrann CD (2015) FNDC5\/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain. Brain Plast 155\u201361. https:\/\/doi.org\/10.3233\/BPL-150019","DOI":"10.3233\/BPL-150019"},{"issue":"13","key":"11861_CR7","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.1111\/jcmm.16612","volume":"20","author":"M Baghi","year":"2021","unstructured":"Baghi M, Yadegari E, Rostamian Delavar M, Peymani M, Ganjalikhani-Hakemi M, Salari M, Nasr-Esfahani MH, Megraw TL, Ghaedi K (2021) MiR-193b deregulation is associated with Parkinson\u2019s disease. J Cell Mol Med 20(13):6348\u20136360. https:\/\/doi.org\/10.1111\/jcmm.16612","journal-title":"J Cell Mol Med"},{"key":"11861_CR8","doi-asserted-by":"publisher","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 23;116(2):281\u2009\u2013\u200997. https:\/\/doi.org\/10.1016\/s0092-8674(04)00045-5","DOI":"10.1016\/s0092-8674(04)00045-5"},{"key":"11861_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrm2619","volume":"10","author":"P Brodersen","year":"2009","unstructured":"Brodersen P, Voinnet O (2009) Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 10:141\u2013148. https:\/\/doi.org\/10.1038\/nrm2619","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"11861_CR10","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3390\/ijms27020930","volume":"27","author":"Y \u00dcnal","year":"2026","unstructured":"\u00dcnal Y, Akba\u015f D, \u00d6zdemir \u00c7, Edg\u00fcnl\u00fc T (2026) Dysregulated MicroRNAs in Parkinson\u2019s Disease: Pathogenic Mechanisms and Biomarker Potential. Int J Mol Sci 27(2):930. https:\/\/doi.org\/10.3390\/ijms27020930","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11861_CR11","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s42003-025-08850-x","volume":"31","author":"L Cai","year":"2025","unstructured":"Cai L, Liu Y, Tang S, Deng S, Zhang L, Liao X, Zhang B, Han B, Xie R (2025) Irisin inhibits dopaminergic neuron lactate metabolism and repairs mitochondrial function to alleviate Parkinson\u2019s disease by activating SIRT1 signaling pathway. Commun Biol 31(1):1516. https:\/\/doi.org\/10.1038\/s42003-025-08850-x","journal-title":"Commun Biol"},{"issue":"1","key":"11861_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41531-023-00453-9","volume":"31","author":"X Zhang","year":"2023","unstructured":"Zhang X, Xu S, Hu Y, Liu Q, Liu C, Chai H, Luo Y, Jin L, Li S (2023) Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson\u2019s disease. NPJ Parkinsons Dis 31(1):13. https:\/\/doi.org\/10.1038\/s41531-023-00453-9","journal-title":"NPJ Parkinsons Dis"},{"key":"11861_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1745017901814010089","volume":"30","author":"A Oliveira de Carvalho","year":"2018","unstructured":"Oliveira de Carvalho A, Filho ASS, Murillo-Rodriguez E, Rocha NB, Carta MG, Machado S (2018) Physical Exercise For Parkinson\u2019s Disease: Clinical And Experimental Evidence. Clin Pract Epidemiol Ment Health 30:14:89\u201398. https:\/\/doi.org\/10.2174\/1745017901814010089","journal-title":"Clin Pract Epidemiol Ment Health"},{"issue":"10","key":"11861_CR14","doi-asserted-by":"publisher","first-page":"7153","DOI":"10.1074\/jbc.M109.053942","volume":"5","author":"N Petrovic","year":"2010","unstructured":"Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 5(10):7153\u20137164. https:\/\/doi.org\/10.1074\/jbc.M109.053942","journal-title":"J Biol Chem"},{"key":"11861_CR15","doi-asserted-by":"publisher","unstructured":"Noronha O, Mesarosovo L, Anink JJ, Iyer A, Aronica E, Mills JD (2022) Differentially expressed miRNAs in age-related neurodegenerative diseases: A Meta-Analysis. Genes (Basel) 9;13(6):1034. https:\/\/doi.org\/10.3390\/genes13061034","DOI":"10.3390\/genes13061034"},{"key":"11861_CR16","doi-asserted-by":"publisher","first-page":"999211","DOI":"10.3389\/fendo.2022.999211","volume":"20","author":"B Deng","year":"2022","unstructured":"Deng B, Tang X, Wang Y (2022) Regulation and bioinformatic analysis of circ_0015891\/miR-129-1-3p axis in methamphetamine-induced dopaminergic apoptosis. Front Endocrinol (Lausanne) 20:13:999211. https:\/\/doi.org\/10.3389\/fendo.2022.999211","journal-title":"Front Endocrinol (Lausanne)"},{"key":"11861_CR17","doi-asserted-by":"publisher","first-page":"131369","DOI":"10.1016\/j.jhazmat.2023.131369","volume":"5","author":"W Duan","year":"2023","unstructured":"Duan W, Liu C, Zhou J, Yu Q, Duan Y, Zhang T, Li Y, Fu G, Sun Y, Tian J, Xia Z, Yang Y, Liu Y, Xu S (2023) Upregulation of mitochondrial calcium uniporter contributes to paraquat-induced neuropathology linked to Parkinson\u2019s disease via imbalanced OPA1 processing. J Hazard Mater 5:453:131369. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.131369","journal-title":"J Hazard Mater"},{"issue":"8","key":"11861_CR18","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/j.bbagen.2018.05.004","volume":"1862","author":"J Fernandes","year":"2018","unstructured":"Fernandes J, Vieira AS, Kramer-Soares JC, Da Silva EA, Lee KS, Lopes-Cendes I, Arida RM (2018) Hippocampal microRNA-mRNA regulatory network is affected by physical exercise. Biochim Biophys Acta Gen Subj 1862(8):1711\u20131720. https:\/\/doi.org\/10.1016\/j.bbagen.2018.05.004","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"10","key":"11861_CR19","first-page":"6619","volume":"15","author":"M Wang","year":"2019","unstructured":"Wang M, Sun H, Yao Y, Tang X, Wu B (2019) MicroRNA-217\/138-5p downregulation inhibits inflammatory response, oxidative stress and the induction of neuronal apoptosis in MPP+-induced SH-SY5Y cells. Am J Transl Res 15(10):6619\u20136631","journal-title":"Am J Transl Res"},{"issue":"7","key":"11861_CR20","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1080\/00207454.2020.1835899","volume":"132","author":"S Xie","year":"2022","unstructured":"Xie S, Niu W, Xu F, Wang Y, Hu S, Niu C (2022) Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson\u2019s disease. Int J Neurosci 132(7):673\u2013688. https:\/\/doi.org\/10.1080\/00207454.2020.1835899","journal-title":"Int J Neurosci"},{"key":"11861_CR21","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.2147\/JIR.S304461","volume":"26","author":"X Feng","year":"2021","unstructured":"Feng X, Hu J, Zhan F, Luo D, Hua F, Xu G (2021) MicroRNA-138-5p Regulates Hippocampal Neuroinflammation and Cognitive Impairment by NLRP3\/Caspase-1 Signaling Pathway in Rats. J Inflamm Res 26:14:1125\u20131143. https:\/\/doi.org\/10.2147\/JIR.S304461","journal-title":"J Inflamm Res"},{"issue":"1","key":"11861_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.5114\/fn.2020.94002","volume":"58","author":"C Sun","year":"2020","unstructured":"Sun C, Jia N, Li R, Zhang Z, Zhong Y, Han K (2020) miR-143-3p inhibition promotes neuronal survival in an Alzheimer\u2019s disease cell model by targeting neuregulin-1. Folia Neuropathol 58(1):10\u201321. https:\/\/doi.org\/10.5114\/fn.2020.94002","journal-title":"Folia Neuropathol"},{"key":"11861_CR23","doi-asserted-by":"publisher","first-page":"118266","DOI":"10.1016\/j.ecoenv.2025.118266","volume":"15","author":"H Mao","year":"2025","unstructured":"Mao H, Wei Y, Liu C, Yang J, Su L, Cen Y, Wang F, Zhu D, Deng Y, Li Y (2025) Mechanism of miR-143 regulating ERK5 signaling pathway-mediated manganese-induced striatal neuronal apoptosis. Ecotoxicol Environ Saf 15:298:118266. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118266","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"11861_CR24","doi-asserted-by":"publisher","first-page":"113684","DOI":"10.1016\/j.yexcr.2023.113684","volume":"15","author":"Y Liang","year":"2023","unstructured":"Liang Y, Gu M, Liang X, Zhou Y, Yang Q, Wang Z, Yao W, Gao X, Chen S (2023) von Hippel-Lindau-targeting microRNA-143-3p attenuates mitochondrial abnormality via AMPK\/PGC-1\u03b1 axis in Parkinson\u2019s disease. Exp Cell Res 15(2):113684. https:\/\/doi.org\/10.1016\/j.yexcr.2023.113684","journal-title":"Exp Cell Res"},{"issue":"1","key":"11861_CR25","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3390\/ijms24010712","volume":"31","author":"M Salemi","year":"2022","unstructured":"Salemi M, Marchese G, Lanza G, Cosentino FII, Salluzzo MG, Schillaci FA, Ventola GM, Cordella A, Ravo M, Ferri R (2022) Role and Dysregulation of miRNA in Patients with Parkinson\u2019s Disease. Int J Mol Sci 31(1):712. https:\/\/doi.org\/10.3390\/ijms24010712","journal-title":"Int J Mol Sci"},{"key":"11861_CR26","doi-asserted-by":"publisher","unstructured":"Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX, Li XX, Zhang C, Xie SY, Wang PY (2013) Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One 21;8(5):e63648. https:\/\/doi.org\/10.1371\/journal.pone.0063648","DOI":"10.1371\/journal.pone.0063648"},{"key":"11861_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.omtn.2018.01.005","volume":"1","author":"AE Roser","year":"2018","unstructured":"Roser AE, Caldi Gomes L, Halder R, Jain G, Maass F, T\u00f6nges L, Tatenhorst L, B\u00e4hr M, Fischer A, Lingor P (2018) miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons. Mol Ther Nucleic Acids 1:11:9\u201322. https:\/\/doi.org\/10.1016\/j.omtn.2018.01.005","journal-title":"Mol Ther Nucleic Acids"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11861-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11861-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11861-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:53:01Z","timestamp":1777459981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11861-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11861"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11861-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"9 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare their consent to participate in this work and publish it.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"696"}}