{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:05:41Z","timestamp":1791335141522,"version":"4.3.1"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11862-3","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:54:31Z","timestamp":1777370071000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting NAV2-mediated Wnt\/\u03b2-catenin signaling in rheumatoid arthritis: current evidence and emerging therapeutic approaches"],"prefix":"10.1007","volume":"53","author":[{"given":"Dinesh","family":"Padmanaban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"6","key":"11862_CR1","first-page":"1166","volume":"29","author":"A Spindler","year":"2002","unstructured":"Spindler A, Bellomio V, Berman A, Lucero E, Baigorria M, Paz S et al (2002) Prevalence of rheumatoid arthritis in Tucum\u00e1n, Argentina. J Rheumatol 29(6):1166\u20131170 PubMed PMID: 12064829","journal-title":"J Rheumatol"},{"issue":"3","key":"11862_CR2","doi-asserted-by":"publisher","first-page":"S265","DOI":"10.1186\/ar578","volume":"4","author":"AJ Silman","year":"2002","unstructured":"Silman AJ, Pearson JE (2002) Epidemiology and genetics of rheumatoid arthritis. Arthritis Res Ther 4(3):S265. https:\/\/doi.org\/10.1186\/ar578","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"11862_CR3","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/cells9040880","volume":"9","author":"YJ Lin","year":"2020","unstructured":"Lin YJ, Anzaghe M, Sch\u00fclke S (2020) Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis. Cells 9(4):880. https:\/\/doi.org\/10.3390\/cells9040880","journal-title":"Cells"},{"issue":"1","key":"11862_CR4","first-page":"40","volume":"31","author":"N Spinel-Bejarano","year":"2013","unstructured":"Spinel-Bejarano N, Quintana G, Heredia R, Yunis JJ, Caminos JE, Garc\u00e9s MF et al (2013) Comparative study of elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis in a Colombian population: clinical, laboratory and HLA-DRB1 findings. Clin Exp Rheumatol 31(1):40\u201346 PubMed PMID: 22935200","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"11862_CR5","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1093\/rheumatology\/keq135","volume":"49","author":"CM Bartels","year":"2010","unstructured":"Bartels CM, Bell CL, Shinki K, Rosenthal A, Bridges AJ (2010) Changing trends in serious extra-articular manifestations of rheumatoid arthritis among United State veterans over 20 years. Rheumatol Oxf Engl 49(9):1670\u20131675. https:\/\/doi.org\/10.1093\/rheumatology\/keq135PubMed PMID: 20463190; PubMed Central PMCID: PMC2919197","journal-title":"Rheumatol Oxf Engl"},{"issue":"1","key":"11862_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1136\/annrheumdis-2017-212131","volume":"77","author":"M Holmqvist","year":"2018","unstructured":"Holmqvist M, Ljung L, Askling J (2018) Mortality following new-onset Rheumatoid Arthritis: has modern Rheumatology had an impact? Ann Rheum Dis 77(1):85\u201391. https:\/\/doi.org\/10.1136\/annrheumdis-2017-212131","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"11862_CR7","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1016\/s0720-048x","volume":"27","author":"W Grassi","year":"1998","unstructured":"Grassi W, De Angelis R, Lamanna G, Cervini C (1998) The clinical features of rheumatoid arthritis. Eur J Radiol 27(Suppl 1):S18\u201324. https:\/\/doi.org\/10.1016\/s0720-048x(98)00038-2 PubMed PMID: 9652497","journal-title":"Eur J Radiol"},{"key":"11862_CR8","unstructured":"CDC Arthritis [Internet]. 2025 [cited 2025 Dec 2]. Rheumatoid Arthritis. Available from: https:\/\/www.cdc.gov\/arthritis\/rheumatoid-arthritis\/index.html"},{"issue":"5","key":"11862_CR9","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1136\/annrheumdis-2011-200990","volume":"71","author":"DM Gerlag","year":"2012","unstructured":"Gerlag DM, Raza K, van Baarsen LGM, Brouwer E, Buckley CD, Burmester GR et al (2012) EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis 71(5):638\u2013641. https:\/\/doi.org\/10.1136\/annrheumdis-2011-200990PubMed PMID: 22387728; PubMed Central PMCID: PMC3329228","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"11862_CR10","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3390\/cells8070700","volume":"8","author":"B Lucchino","year":"2019","unstructured":"Lucchino B, Spinelli FR, Iannuccelli C, Guzzo MP, Conti F, Franco MD (2019) Mucosa\u2013Environment Interactions in the Pathogenesis of Rheumatoid Arthritis. Cells 8(7):700. https:\/\/doi.org\/10.3390\/cells8070700","journal-title":"Cells"},{"issue":"1","key":"11862_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13075-021-02593-w","volume":"23","author":"RE Costello","year":"2021","unstructured":"Costello RE, Humphreys JH, Sergeant JC, Haris M, Stirling F, Raza K et al (2021) Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort. Arthritis Res Ther 23(1):210. https:\/\/doi.org\/10.1186\/s13075-021-02593-w","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"11862_CR12","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.3390\/jcm14082710","volume":"14","author":"A Marino","year":"2025","unstructured":"Marino A, Currado D, Berardicurti O, Vomero M, Kun L, Di Corcia LP et al (2025) Association Between the Use of Oral Contraceptives and the Development of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. J Clin Med 14(8):2710. https:\/\/doi.org\/10.3390\/jcm14082710","journal-title":"J Clin Med"},{"issue":"11","key":"11862_CR13","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1136\/annrheumdis-2013-203323","volume":"73","author":"Z Jin","year":"2014","unstructured":"Jin Z, Xiang C, Cai Q, Wei X, He J (2014) Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis 73(11):1962\u20131967. https:\/\/doi.org\/10.1136\/annrheumdis-2013-203323PubMed PMID: 23897767","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"11862_CR14","first-page":"174","volume":"4","author":"S Li","year":"2013","unstructured":"Li S, Yu Y, Yue Y, Zhang Z, Su K (2013) Microbial Infection and Rheumatoid Arthritis. J Clin Cell Immunol 4(6):174 doi:10.4172\/2155-9899.1000174 PubMed PMID: 25133066; PubMed Central PMCID: PMC4131749","journal-title":"J Clin Cell Immunol"},{"issue":"6","key":"11862_CR15","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1136\/ard.2009.120170","volume":"69","author":"EW Karlson","year":"2010","unstructured":"Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B et al (2010) Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis 69(6):1077\u20131085. https:\/\/doi.org\/10.1136\/ard.2009.120170PubMed PMID: 20233754; PubMed Central PMCID: PMC2933175","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"11862_CR16","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1172\/JCI115734","volume":"89","author":"AA Postigo","year":"1992","unstructured":"Postigo AA, Garcia-Vicu\u00f1a R, Diaz-Gonzalez F, Arroyo AG, Land\u00e1zuri MOD, Chi-Rosso G et al (1992) Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1). J Clin Invest 89(5):1445\u20131452 doi:10.1172\/JCI115734 PubMed PMID: 1373738","journal-title":"J Clin Invest"},{"issue":"1","key":"11862_CR17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/ar2107","volume":"9","author":"SK Lundy","year":"2007","unstructured":"Lundy SK, Sarkar S, Tesmer LA, Fox DA (2007) Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther 9(1):202. https:\/\/doi.org\/10.1186\/ar2107","journal-title":"Arthritis Res Ther"},{"key":"11862_CR18","doi-asserted-by":"publisher","first-page":"689711","DOI":"10.3389\/fmed","volume":"9","author":"VC Rom\u00e3o","year":"2022","unstructured":"Rom\u00e3o VC, Fonseca JE (2022) Disease mechanisms in preclinical rheumatoid arthritis: A narrative review. Front Med 9:689711. https:\/\/doi.org\/10.3389\/fmed.2022.689711 PubMed PMID: 36059838; PubMed Central PMCID: PMC9437632","journal-title":"Front Med"},{"issue":"6","key":"11862_CR19","doi-asserted-by":"publisher","first-page":"726598","DOI":"10.1155\/2013\/726598","volume":"35","author":"F Ingegnoli","year":"2013","unstructured":"Ingegnoli F, Castelli R, Gualtierotti R (2013) Rheumatoid Factors: Clinical Applications. Dis Markers 35(6):726598. https:\/\/doi.org\/10.1155\/2013\/726598","journal-title":"Dis Markers"},{"issue":"9","key":"11862_CR20","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1136\/annrheumdis-2014-205227","volume":"74","author":"C Rakieh","year":"2015","unstructured":"Rakieh C, Nam JL, Hunt L, Hensor EMA, Das S, Bissell LA et al (2015) Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study. Ann Rheum Dis 74(9):1659\u20131666. https:\/\/doi.org\/10.1136\/annrheumdis-2014-205227PubMed PMID: 24728331","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"11862_CR21","doi-asserted-by":"publisher","first-page":"105841","DOI":"10.1016\/j.jbspin.2024.105841","volume":"92","author":"J Hui","year":"2025","unstructured":"Hui J, He D, Liu C, Shi P, Zhou R, Kang M et al (2025) A large-scale multi-omics polygenic risk score analysis identified candidate risk locus associated with rheumatoid arthritis. Joint Bone Spine 92(3):105841. https:\/\/doi.org\/10.1016\/j.jbspin.2024.105841","journal-title":"Joint Bone Spine"},{"issue":"12","key":"11862_CR22","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1136\/annrheumdis-2012-202127","volume":"72","author":"LA van de Stadt","year":"2013","unstructured":"van de Stadt LA, Witte BI, Bos WH, van Schaardenburg D (2013) A prediction rule for the development of arthritis in seropositive arthralgia patients. Ann Rheum Dis 72(12):1920\u20131926. https:\/\/doi.org\/10.1136\/annrheumdis-2012-202127PubMed PMID: 23178208","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"11862_CR23","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.semarthrit.2004","volume":"34","author":"ED Ferucci","year":"2005","unstructured":"Ferucci ED, Templin DW, Lanier AP (2005) Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literature. Semin Arthritis Rheum 34(4):662\u2013667. https:\/\/doi.org\/10.1016\/j.semarthrit.200408.003 PubMed PMID: 15692959","journal-title":"Semin Arthritis Rheum"},{"issue":"9","key":"11862_CR24","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1111\/jog.13370","volume":"43","author":"L Ren","year":"2017","unstructured":"Ren L, Guo P, Sun QM, Liu H, Chen Y, Huang Y et al (2017) Number of parity and the risk of rheumatoid arthritis in women: A dose-response meta-analysis of observational studies. J Obstet Gynaecol Res 43(9):1428\u20131440. https:\/\/doi.org\/10.1111\/jog.13370PubMed PMID: 28613016","journal-title":"J Obstet Gynaecol Res"},{"issue":"2","key":"11862_CR25","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/ard.2006.060004","volume":"66","author":"SS Bhatia","year":"2007","unstructured":"Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD et al (2007) Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis 66(2):267\u2013269. https:\/\/doi.org\/10.1136\/ard.2006.060004PubMed PMID: 16868018; PubMed Central PMCID: PMC1798510","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"11862_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249","volume":"143","author":"CJ Edwards","year":"2006","unstructured":"Edwards CJ, Cooper C (2006) Early environmental factors and rheumatoid arthritis. Clin Exp Immunol 143(1):1\u20135. https:\/\/doi.org\/10.1111\/j.1365-22492005.02940.x PubMed PMID: 16367927; PubMed Central PMCID: PMC1809562","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"11862_CR27","doi-asserted-by":"publisher","first-page":"e003785","DOI":"10.1136\/rmdopen-2023-003785","volume":"10","author":"QA Dumoulin","year":"2024","unstructured":"Dumoulin QA, Boeren AMP, Krijbolder DI, Willemze A, de Jong PHP, van Mulligen E et al (2024) When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk. RMD Open 10(1):e003785. https:\/\/doi.org\/10.1136\/rmdopen-2023-003785PubMed PMID: 38216289; PubMed Central PMCID: PMC10806477","journal-title":"RMD Open"},{"issue":"5","key":"11862_CR28","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/BOR.0000000000000638","volume":"31","author":"C Perricone","year":"2019","unstructured":"Perricone C, Ceccarelli F, Matteo S, Di Carlo G, Bogdanos DP, Lucchetti R et al (2019) Porphyromonas gingivalis and rheumatoid arthritis. Curr Opin Rheumatol 31(5):517. https:\/\/doi.org\/10.1097\/BOR.0000000000000638","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"11862_CR29","first-page":"1091","volume":"152","author":"KR Aupperle","year":"1998","unstructured":"Aupperle KR, Boyle DL, Hendrix M, Seftor EA, Zvaifler NJ, Barbosa M et al (1998) Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol 152(4):1091\u20131098 PubMed PMID: 9546370; PubMed Central PMCID: PMC1858248","journal-title":"Am J Pathol"},{"issue":"2","key":"11862_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrrheum.2010.173","volume":"7","author":"CG Borrero","year":"2011","unstructured":"Borrero CG, Mountz JM, Mountz JD (2011) Emerging MRI methods in rheumatoid arthritis. Nat Rev Rheumatol 7(2):85\u201395. https:\/\/doi.org\/10.1038\/nrrheum.2010.173","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"11862_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.immuni","volume":"46","author":"GS Firestein","year":"2017","unstructured":"Firestein GS, McInnes IB (2017) Immunopathogenesis of Rheumatoid Arthritis. Immunity 46(2):183\u2013196. https:\/\/doi.org\/10.1016\/j.immuni2017.02.006 PubMed PMID: 28228278; PubMed Central PMCID: PMC5385708","journal-title":"Immunity"},{"issue":"10","key":"11862_CR32","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/rheumatology\/ken163","volume":"47","author":"JD Isaacs","year":"2008","unstructured":"Isaacs JD (2008) Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future. Rheumatology 47(10):1461\u20131468. https:\/\/doi.org\/10.1093\/rheumatology\/ken163","journal-title":"Rheumatology"},{"issue":"1","key":"11862_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/tcmj.tcmj_116_18","volume":"31","author":"HC Yu","year":"2019","unstructured":"Yu HC, Lu MC (2019) The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis. Tzu Chi Med J 31(1):5. https:\/\/doi.org\/10.4103\/tcmj.tcmj_116_18","journal-title":"Tzu Chi Med J"},{"issue":"5","key":"11862_CR34","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.it.2021","volume":"42","author":"N Hannemann","year":"2021","unstructured":"Hannemann N, Apparailly F, Courties G (2021) Synovial macrophages: from ordinary eaters to extraordinary multitaskers. Trends Immunol 42(5):368\u2013371. https:\/\/doi.org\/10.1016\/j.it.202103.002 PubMed PMID: 33832864","journal-title":"Trends Immunol"},{"key":"11862_CR35","doi-asserted-by":"publisher","unstructured":"Poole AR, Nelson F, Dahlberg L, Tchetina E, Kobayashi M, Yasuda T et al (2003) Proteolysis of the collagen fibril in osteoarthritis. Biochem Soc Symp. ;(70):115\u201323. https:\/\/doi.org\/10.1042\/bss0700115 PubMed PMID: 14587287","DOI":"10.1042\/bss0700115"},{"issue":"12","key":"11862_CR36","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/j.immuni.2022","volume":"55","author":"S Alivernini","year":"2022","unstructured":"Alivernini S, Firestein GS, McInnes IB (2022) The pathogenesis of rheumatoid arthritis. Immunity 55(12):2255\u20132270. https:\/\/doi.org\/10.1016\/j.immuni.202211.009 PubMed PMID: 36516818","journal-title":"Immunity"},{"issue":"4","key":"11862_CR37","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","volume":"97","author":"K Okamoto","year":"2017","unstructured":"Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A et al (2017) Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems. Physiol Rev 97(4):1295\u20131349. https:\/\/doi.org\/10.1152\/physrev.00036.2016","journal-title":"Physiol Rev"},{"issue":"Suppl 3","key":"11862_CR38","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1186\/ar575","volume":"4","author":"EM Paleolog","year":"2002","unstructured":"Paleolog EM (2002) Angiogenesis in rheumatoid arthritis. Arthritis Res 4(Suppl 3):S81\u201390. https:\/\/doi.org\/10.1186\/ar575PubMed PMID: 12110126; PubMed Central PMCID: PMC3240151","journal-title":"Arthritis Res"},{"issue":"369","key":"11862_CR39","doi-asserted-by":"publisher","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","volume":"8","author":"MF Konig","year":"2016","unstructured":"Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K et al (2016) Aggregatibacter actinomycetemcomitans\u2013induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med 8(369):369ra176\u2013369ra176. https:\/\/doi.org\/10.1126\/scitranslmed.aaj1921","journal-title":"Sci Transl Med"},{"issue":"2","key":"11862_CR40","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/art.30134","volume":"63","author":"YJ Chen","year":"2011","unstructured":"Chen YJ, Chang YT, Wang CB, Wu CY (2011) The risk of cancer in patients with rheumatoid arthritis: a nationwide cohort study in Taiwan. Arthritis Rheum 63(2):352\u2013358. https:\/\/doi.org\/10.1002\/art.30134PubMed PMID: 21279991","journal-title":"Arthritis Rheum"},{"issue":"1","key":"11862_CR41","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4049\/jimmunol.0804144","volume":"183","author":"C Monari","year":"2009","unstructured":"Monari C, Bevilacqua S, Piccioni M, Pericolini E, Perito S, Calvitti M et al (2009) A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production. J Immunol Baltim Md 1950 183(1):191\u2013200. https:\/\/doi.org\/10.4049\/jimmunol.0804144PubMed PMID: 19542430","journal-title":"J Immunol Baltim Md 1950"},{"key":"11862_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ejim.2019.11.009","volume":"71","author":"W Gao","year":"2020","unstructured":"Gao W, Dong X, Yang Z, Mao G, Xing W (2020) Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis. Eur J Intern Med 71:101\u2013103 PubMed PMID: 31757580","journal-title":"Eur J Intern Med"},{"issue":"9","key":"11862_CR43","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.celrep.2017.05.013","volume":"19","author":"SK Tripathi","year":"2017","unstructured":"Tripathi SK, Chen Z, Larjo A, Kanduri K, Nousiainen K, \u00c4ijo T et al (2017) Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation. Cell Rep 19(9):1888\u20131901. https:\/\/doi.org\/10.1016\/j.celrep.2017.05.013PubMed PMID: 28564606","journal-title":"Cell Rep"},{"issue":"8","key":"11862_CR44","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.3390\/ph18081152","volume":"18","author":"T Bobkova","year":"2025","unstructured":"Bobkova T, Bobkov A, Li Y (2025) Pharmacological Inhibition of the PI3K\/AKT\/mTOR Pathway in Rheumatoid Arthritis Synoviocytes: A Systematic Review and Meta-Analysis (Preclinical). Pharmaceuticals 18(8):1152. https:\/\/doi.org\/10.3390\/ph18081152","journal-title":"Pharmaceuticals"},{"issue":"10","key":"11862_CR45","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3390\/biom11101444","volume":"11","author":"RH Whitaker","year":"2021","unstructured":"Whitaker RH, Cook JG (2021) Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways. Biomolecules 11(10):1444 :10.3390\/biom11101444 PubMed PMID: 34680077; PubMed Central PMCID: PMC8533283","journal-title":"Biomolecules"},{"issue":"4","key":"11862_CR46","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.3390\/ijms22042057","volume":"22","author":"S Terazawa","year":"2021","unstructured":"Terazawa S, Takada M, Sato Y, Nakajima H, Imokawa G (2021) The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38\/ATF2 and JAK2\/STAT3 Cascades. Int J Mol Sci 22(4):2057. https:\/\/doi.org\/10.3390\/ijms22042057PubMed PMID: 33669634; PubMed Central PMCID: PMC7922819","journal-title":"Int J Mol Sci"},{"key":"11862_CR47","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2147\/ITT.S288550","volume":"10","author":"LC Arneson","year":"2021","unstructured":"Arneson LC, Carroll KJ, Ruderman EM (2021) Bruton\u2019s Tyrosine Kinase Inhibition for the Treatment of Rheumatoid Arthritis. ImmunoTargets Ther 10:333\u2013342 doi:10.2147\/ITT.S288550 PubMed PMID: 34485183; PubMed Central PMCID: PMC8409514","journal-title":"ImmunoTargets Ther"},{"issue":"9","key":"11862_CR48","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1038\/s41423-021-00696-7","volume":"18","author":"R Wang","year":"2021","unstructured":"Wang R, Li M, Ding Q, Cai J, Yu Y, Liu X et al (2021) Neuron navigator 2 is a novel mediator of rheumatoid arthritis. Cell Mol Immunol 18(9):2288\u20132289. https:\/\/doi.org\/10.1038\/s41423-021-00696-7","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"11862_CR49","doi-asserted-by":"publisher","first-page":"e376","DOI":"10.1002\/ctm2","volume":"11","author":"R Wang","year":"2021","unstructured":"Wang R, Li M, Wu W, Qiu Y, Hu W, Li Z et al (2021) NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt\/\u03b2\u2010catenin signaling pathway in rheumatoid arthritis. Clin Transl Med 11(4):e376. https:\/\/doi.org\/10.1002\/ctm2376 PubMed PMID: 33931978; PubMed Central PMCID: PMC8087903","journal-title":"Clin Transl Med"},{"issue":"1","key":"11862_CR50","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","volume":"8","author":"Q Ding","year":"2023","unstructured":"Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M et al (2023) Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct Target Ther 8(1):68. https:\/\/doi.org\/10.1038\/s41392-023-01331-9","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"11862_CR51","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-022-01050-7","volume":"7","author":"R Wang","year":"2022","unstructured":"Wang R, Cai J, Chen K, Zhu M, Li Z, Liu H et al (2022) STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L\/Cofilin-1 signaling pathway. Signal Transduct Target Ther 7(1):209. https:\/\/doi.org\/10.1038\/s41392-022-01050-7","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"11862_CR52","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1365-2249.2010.04310.x","volume":"164","author":"Z Jiao","year":"2011","unstructured":"Jiao Z, Wang W, Xu H, Wang S, Guo M, Chen Y et al (2011) Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1. Clin Exp Immunol 164(1):66\u201371 .x PubMed PMID: 21235539; PubMed Central PMCID: PMC3074218","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"11862_CR53","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13018-020-01595-9","volume":"15","author":"T Kanai","year":"2020","unstructured":"Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y et al (2020) The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3. J Orthop Surg 15(1):87. https:\/\/doi.org\/10.1186\/s13018-020-01595-9PubMed PMID: 32131874; PubMed Central PMCID: PMC7371465","journal-title":"J Orthop Surg"},{"key":"11862_CR54","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.mtcomm.2018.09.011","volume":"17","author":"K Janakiraman","year":"2018","unstructured":"Janakiraman K, Krishnaswami V, Rajendran V, Natesan S, Kandasamy R (2018) Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights. Mater Today Commun 17:200\u2013213. https:\/\/doi.org\/10.1016\/j.mtcomm.2018.09.011","journal-title":"Mater Today Commun"},{"key":"11862_CR55","doi-asserted-by":"publisher","unstructured":"Eram S, Mujahid M, Bagga P, Arif M, Ahmad MA, Kumar A et al (2019) A review on phytopharmacological activity of alpinia galanga. Int J Pharm Pharm Sci 6\u201311. https:\/\/doi.org\/10.22159\/ijpps.2019v11i3.31352","DOI":"10.22159\/ijpps.2019v11i3.31352"},{"issue":"5","key":"11862_CR56","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/rheumatology\/keg184","volume":"42","author":"S Bas","year":"2003","unstructured":"Bas S, Genevay S, Meyer O, Gabay C (2003) Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatol Oxf Engl 42(5):677\u2013680. https:\/\/doi.org\/10.1093\/rheumatology\/keg184PubMed PMID: 12709545","journal-title":"Rheumatol Oxf Engl"},{"issue":"3","key":"11862_CR57","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.rehab.2015","volume":"59","author":"D Hayashi","year":"2016","unstructured":"Hayashi D, Roemer FW, Guermazi A (2016) Imaging for osteoarthritis. Ann Phys Rehabil Med 59(3):161\u2013169. https:\/\/doi.org\/10.1016\/j.rehab.201512.003 PubMed PMID: 26797169","journal-title":"Ann Phys Rehabil Med"},{"issue":"3","key":"11862_CR58","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s11548-019-02096-9","volume":"15","author":"B Liu","year":"2020","unstructured":"Liu B, Luo J, Huang H (2020) Toward automatic quantification of knee osteoarthritis severity using improved Faster R-CNN. Int J Comput Assist Radiol Surg 15(3):457\u2013466. https:\/\/doi.org\/10.1007\/s11548-019-02096-9PubMed PMID: 31938993","journal-title":"Int J Comput Assist Radiol Surg"},{"issue":"2","key":"11862_CR59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11883-019-0766-x","volume":"21","author":"NN Khanna","year":"2019","unstructured":"Khanna NN, Jamthikar AD, Gupta D, Piga M, Saba L, Carcassi C et al (2019) Rheumatoid Arthritis: Atherosclerosis Imaging and Cardiovascular Risk Assessment Using Machine and Deep Learning\u2013Based Tissue Characterization. Curr Atheroscler Rep 21(2):7. https:\/\/doi.org\/10.1007\/s11883-019-0766-x","journal-title":"Curr Atheroscler Rep"},{"issue":"7","key":"11862_CR60","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1136\/annrheumdis-2016-209744","volume":"76","author":"GJ Fent","year":"2017","unstructured":"Fent GJ, Greenwood JP, Plein S, Buch MH (2017) The role of non-invasive cardiovascular imaging in the assessment of cardiovascular risk in rheumatoid arthritis: where we are and where we need to be. Ann Rheum Dis 76(7):1169\u20131175. https:\/\/doi.org\/10.1136\/annrheumdis-2016-209744","journal-title":"Ann Rheum Dis"},{"key":"11862_CR61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.compmedimag.2019.06.002","volume":"75","author":"P Chen","year":"2019","unstructured":"Chen P, Gao L, Shi X, Allen K, Yang L (2019) Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss. Comput Med Imaging Graph 75:84\u201392. https:\/\/doi.org\/10.1016\/j.compmedimag.2019.06.002","journal-title":"Comput Med Imaging Graph"},{"issue":"1","key":"11862_CR62","doi-asserted-by":"publisher","first-page":"6371","DOI":"10.1038\/s41598-020-63395-9","volume":"10","author":"AA Tolpadi","year":"2020","unstructured":"Tolpadi AA, Lee JJ, Pedoia V, Majumdar S (2020) Deep Learning Predicts Total Knee Replacement from Magnetic Resonance Images. Sci Rep 10(1):6371. https:\/\/doi.org\/10.1038\/s41598-020-63395-9","journal-title":"Sci Rep"},{"issue":"4","key":"11862_CR63","doi-asserted-by":"publisher","first-page":"196","DOI":"10.12790\/jkssh.2013.18.4.196","volume":"18","author":"SJ Woo","year":"2013","unstructured":"Woo SJ, Park MJ (2013) Current Concept of Surgical Management for Rheumatoid Arthritis of the Wrist. J Korean Soc Surg Hand 18(4):196\u2013205","journal-title":"J Korean Soc Surg Hand"},{"key":"11862_CR64","unstructured":"Hospital P (2025) Knee Surgery Types | Effective Procedures to End Knee Pain Safely [Internet]. Nov 21 [cited 2025 Dec 9]. Available from: https:\/\/pentagonhospitals.com\/knee-surgery-types\/"},{"issue":"2","key":"11862_CR65","doi-asserted-by":"publisher","first-page":"102735","DOI":"10.1016\/j.autrev.2020.102735","volume":"20","author":"A Conforti","year":"2021","unstructured":"Conforti A, Di Cola I, Pavlych V, Ruscitti P, Berardicurti O, Ursini F et al (2021) Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. Autoimmun Rev 20(2):102735. https:\/\/doi.org\/10.1016\/j.autrev.2020.102735PubMed PMID: 33346115","journal-title":"Autoimmun Rev"},{"key":"11862_CR66","doi-asserted-by":"publisher","unstructured":"Berwal A, Bairy I,  Gupta A (2019) Demystifying antinuclear antibodies and other serological tests in dermatology practice. Clinical Dermatol Rev 3(1):29\u201333. https:\/\/doi.org\/10.4103\/CDR.CDR_49_18","DOI":"10.4103\/CDR.CDR_49_18"},{"issue":"4","key":"11862_CR67","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.berh.2013","volume":"27","author":"FM McQueen","year":"2013","unstructured":"McQueen FM (2013) Imaging in early rheumatoid arthritis. Best Pract Res Clin Rheumatol 27(4):499\u2013522. https:\/\/doi.org\/10.1016\/j.berh.201309.005 PubMed PMID: 24315051","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"11862_CR68","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13075-022-02972-x","volume":"24","author":"A Bird","year":"2022","unstructured":"Bird A, Oakden-Rayner L, McMaster C, Smith LA, Zeng M, Wechalekar MD et al (2022) Artificial intelligence and the future of radiographic scoring in rheumatoid arthritis: a viewpoint. Arthritis Res Ther 24(1):268. https:\/\/doi.org\/10.1186\/s13075-022-02972-x","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"11862_CR69","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2217\/ijr.14.47","volume":"9","author":"SM Goodman","year":"2014","unstructured":"Goodman SM, Ravi B, Hawker G (2014) Outcomes in rheumatoid arthritis patients undergoing total joint arthroplasty. Int J Clin Rheumatol 9(6):585\u2013593. https:\/\/doi.org\/10.2217\/ijr.14.47","journal-title":"Int J Clin Rheumatol"},{"issue":"3","key":"11862_CR70","doi-asserted-by":"publisher","first-page":"e509","DOI":"10.1002\/mco2","volume":"5","author":"Y Gao","year":"2024","unstructured":"Gao Y, Zhang Y, Liu X (2024) Rheumatoid arthritis: pathogenesis and therapeutic advances. MedComm 5(3):e509. https:\/\/doi.org\/10.1002\/mco2509 PubMed PMID: 38469546; PubMed Central PMCID: PMC10925489","journal-title":"MedComm"},{"key":"11862_CR71","doi-asserted-by":"crossref","unstructured":"Nguyen S, Kaufman M, Shetty M, Rovzar C, Friedlander A, Fredericson M (2025) Lifestyle Interventions and Supplements for Joint and Arthritis Pain: A Narrative Review. Am J Lifestyle Med 15598276251395980. 101177\/15598276251395980 PubMed PMID: 41246047; PubMed Central PMCID: PMC12618219","DOI":"10.1177\/15598276251395980"},{"key":"11862_CR72","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2147\/JIR.S287242","volume":"14","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Duan HX, Li RL, Sun JY, Liu J, Peng W et al (2021) Inducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis. J Inflamm Res 14:217\u2013236 S287242 PubMed PMID: 33542641; PubMed Central PMCID: PMC7851583","journal-title":"J Inflamm Res"},{"key":"11862_CR73","doi-asserted-by":"publisher","unstructured":"Lei Xjing, Sun H, mei, Qu Y, xia, Xu Q zhu, Zhou Y, Xiao H et al (2025) Research overview of ethnic medicines for the treatment of rheumatoid arthritis. Front Pharmacol. ;16. https:\/\/doi.org\/10.3389\/fphar.2025.1662130","DOI":"10.3389\/fphar.2025.1662130"},{"key":"11862_CR74","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2147\/DDDT.S330947","volume":"16","author":"N Wu","year":"2022","unstructured":"Wu N, Yuan T, Yin Z, Yuan X, Sun J, Wu Z et al (2022) Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis. Drug Des Devel Ther 16:435\u2013466 330947 PubMed PMID: 35221674; PubMed Central PMCID: PMC8865873","journal-title":"Drug Des Devel Ther"},{"key":"11862_CR75","doi-asserted-by":"publisher","first-page":"6394625","DOI":"10.1155\/2020\/6394625","volume":"2020","author":"Y Gao","year":"2020","unstructured":"Gao Y, Yu WX, Duan XM, Ni LL, Liu H, Zhao HR et al (2020) Wasp Venom Possesses Potential Therapeutic Effect in Experimental Models of Rheumatoid Arthritis. Evid-Based Complement Altern Med ECAM 2020:6394625. https:\/\/doi.org\/10.1155\/2020\/6394625PubMed PMID: 32328136; PubMed Central PMCID: PMC7165351","journal-title":"Evid-Based Complement Altern Med ECAM"},{"issue":"9","key":"11862_CR76","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1093\/rheumatology\/39.9.975","volume":"39","author":"A Maetzel","year":"2000","unstructured":"Maetzel A, Wong A, Strand V, Tugwell P, Wells G, Bombardier C (2000) Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatol Oxf Engl 39(9):975\u2013981. https:\/\/doi.org\/10.1093\/rheumatology\/39.9.975PubMed PMID: 10986302","journal-title":"Rheumatol Oxf Engl"},{"issue":"1","key":"11862_CR77","doi-asserted-by":"publisher","first-page":"CD002047","DOI":"10.1002\/14651858","volume":"2002","author":"M Osiri","year":"2003","unstructured":"Osiri M, Shea B, Robinson V, Suarez-Almazor M, Strand V, Tugwell P et al (2003) Leflunomide for treating rheumatoid arthritis. Cochrane Database Syst Rev 2002(1):CD002047. https:\/\/doi.org\/10.1002\/14651858CD002047 PubMed PMID: 12535423; PubMed Central PMCID: PMC8437750","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"11862_CR78","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/s0002-9343(","volume":"98","author":"A randomized trial","year":"1995","unstructured":"A randomized trial (1995) of hydroxychloroquine in early rheumatoid arthritis: the HERA Study. Am J Med 98(2):156\u2013168. https:\/\/doi.org\/10.1016\/s0002-9343(99)80399-4 PubMed PMID: 7847432","journal-title":"Am J Med"},{"issue":"6","key":"11862_CR79","doi-asserted-by":"publisher","first-page":"CD012095","DOI":"10.1002\/14651858.CD012095.pub2","volume":"2017","author":"M Fidahic","year":"2017","unstructured":"Fidahic M, Jelicic Kadic A, Radic M, Puljak L (2017) Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev 2017(6):CD012095. https:\/\/doi.org\/10.1002\/14651858.CD012095.pub2PubMed PMID: 28597983; PubMed Central PMCID: PMC6481589","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"11862_CR80","doi-asserted-by":"publisher","first-page":"CD012437","DOI":"10.1002\/14651858","volume":"11","author":"JA Singh","year":"2016","unstructured":"Singh JA, Hossain A, Tanjong Ghogomu E, Mudano AS, Tugwell P, Wells GA (2016) Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA). Cochrane Database Syst Rev 11(11):CD012437. https:\/\/doi.org\/10.1002\/14651858CD012437 PubMed PMID: 27855242; PubMed Central PMCID: PMC6469573","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"11862_CR81","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.5114\/aoms.2014.47827","volume":"10","author":"K Lis","year":"2014","unstructured":"Lis K, Kuzawi\u0144ska O, Ba\u0142kowiec-Iskra E (2014) Tumor necrosis factor inhibitors \u2013 state of knowledge. Arch Med Sci AMS 10(6):1175\u20131185. https:\/\/doi.org\/10.5114\/aoms.2014.47827PubMed PMID: 25624856; PubMed Central PMCID: PMC4296073","journal-title":"Arch Med Sci AMS"},{"issue":"6","key":"11862_CR82","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1136\/annrheumdis-2016-209166","volume":"75","author":"T D\u00f6rner","year":"2016","unstructured":"D\u00f6rner T, Strand V, Cornes P, Gon\u00e7alves J, Gul\u00e1csi L, Kay J et al (2016) The changing landscape of biosimilars in rheumatology. Ann Rheum Dis 75(6):974\u2013982. https:\/\/doi.org\/10.1136\/annrheumdis-2016-209166","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"11862_CR83","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.amjmed.2007.04.005","volume":"120","author":"V Majithia","year":"2007","unstructured":"Majithia V, Geraci SA (2007) Rheumatoid Arthritis: Diagnosis and Management. Am J Med 120(11):936\u2013939. https:\/\/doi.org\/10.1016\/j.amjmed.2007.04.005","journal-title":"Am J Med"},{"issue":"1","key":"11862_CR84","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1710-1492-9-30","volume":"9","author":"D Liu","year":"2013","unstructured":"Liu D, Ahmet A, Ward L, Krishnamoorthy P, Mandelcorn ED, Leigh R et al (2013) A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol Off J Can Soc Allergy Clin Immunol 9(1):30. https:\/\/doi.org\/10.1186\/1710-1492-9-30PubMed PMID: 23947590; PubMed Central PMCID: PMC3765115","journal-title":"Allergy Asthma Clin Immunol Off J Can Soc Allergy Clin Immunol"},{"key":"11862_CR85","unstructured":"You-bin L (2011) Studies on chemical constituents and pharmaceutics activity of Achyranthes bidentata Bl. Strait Pharm J [Internet]. [cited 2025 Dec 11]. Available from: https:\/\/www.semanticscholar.org\/paper\/Studies-on-chemical-constituents-and-pharmaceutics-You-bin\/b4cee0aff77c1681c3938c3536af93487cf8025c"},{"key":"11862_CR86","unstructured":"Jawahar DJ, Natarajan J, Koshy R, Byran G, Murugan V, Suresh B (2008) Anti-arthritic activity of bark extracts of Alangium salviifolium wang. Rasayan J Chem 1(3):433\u2013436"},{"issue":"3","key":"11862_CR87","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/pca.2407","volume":"24","author":"H Sun","year":"2013","unstructured":"Sun H, Wang M, Zhang A, Ni B, Dong H, Wang X, UPLC-Q-TOF (2013) -HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach. Phytochem Anal PCA 24(3):263\u2013276. https:\/\/doi.org\/10.1002\/pca.2407PubMed PMID: 23225552","journal-title":"Phytochem Anal PCA"},{"key":"11862_CR88","unstructured":"Rahman H, Eswaraiah MC, Dutta AM (2016) Anti-arthritic activity of leaves and oil of Aquilaria agallocha. Vol. 1. ;1"},{"key":"11862_CR89","unstructured":"Kale VM, Namdeo AG (2014) Antiarthritic effect of galangin isolated from rhizomes of Alpinia officinarum in complete Freund\u2019s adjuvant-induced arthritis in rats. Int J Pharm Pharm Sci 6(4):499\u2013505"},{"issue":"1","key":"11862_CR90","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.chroma.2006.08.085","volume":"1134","author":"LW Qi","year":"2006","unstructured":"Qi LW, Yu QT, Li P, Li SL, Wang YX, Sheng LH et al (2006) Quality evaluation of Radix Astragali through a simultaneous determination of six major active isoflavonoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. J Chromatogr A 1134(1):162\u2013169. https:\/\/doi.org\/10.1016\/j.chroma.2006.08.085","journal-title":"J Chromatogr A"},{"key":"11862_CR91","unstructured":"3.Lovely-Prabha-Vinay-Jain-Gyan-Prakash-Prabhakar-Rohit-Kumar-Bijauliya.pdf [Internet]. [cited 2025 Dec 9]. Available from: https:\/\/ijppr.humanjournals.com\/wp-content\/uploads\/2022\/11\/3.Lovely-Prabha-Vinay-Jain-Gyan-Prakash-Prabhakar-Rohit-Kumar-Bijauliya.pdf"},{"key":"11862_CR92","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.biopha.2018.01.072","volume":"99","author":"A Hosseini","year":"2018","unstructured":"Hosseini A, Hosseinzadeh H (2018) Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother Biomedecine Pharmacother 99:411\u2013421. https:\/\/doi.org\/10.1016\/j.biopha.2018.01.072PubMed PMID: 29367110","journal-title":"Biomed Pharmacother Biomedecine Pharmacother"},{"issue":"41","key":"11862_CR93","doi-asserted-by":"publisher","first-page":"27799","DOI":"10.1074\/jbc.M800938200","volume":"283","author":"M Hilvo","year":"2008","unstructured":"Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A et al (2008) Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J Biol Chem 283(41):27799\u201327809. https:\/\/doi.org\/10.1074\/jbc.M800938200 PubMed PMID: 18703501","journal-title":"J Biol Chem"},{"issue":"10","key":"11862_CR94","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1089\/acm.2017.0098","volume":"23","author":"JW Daily","year":"2017","unstructured":"Daily JW, Zhang T, Cao S, Park S (2017) Efficacy and Safety of GuiZhi-ShaoYao-ZhiMu Decoction for Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Altern Complement Med N Y N 23(10):756\u2013770. https:\/\/doi.org\/10.1089\/acm.2017.0098PubMed PMID: 28609129","journal-title":"J Altern Complement Med N Y N"},{"key":"11862_CR95","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12967-016-0921-x","volume":"14","author":"Q Guo","year":"2016","unstructured":"Guo Q, Mao X, Zhang Y, Meng S, Xi Y, Ding Y et al (2016) Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance. J Transl Med 14:165. https:\/\/doi.org\/10.1186\/s12967-016-0921-xPubMed PMID: 27277474; PubMed Central PMCID: PMC4898408","journal-title":"J Transl Med"},{"issue":"2","key":"11862_CR96","first-page":"318","volume":"34","author":"JA Hodge","year":"2016","unstructured":"Hodge JA, Kawabata TT, Krishnaswami S, Clark JD, Telliez JB, Dowty ME et al (2016) The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. Clin Exp Rheumatol 34(2):318\u2013328 PubMed PMID: 26966791","journal-title":"Clin Exp Rheumatol"},{"key":"#cr-split#-11862_CR97.1","unstructured":"Judith A (2004) Halstead. Orthopedic Nursing Caring for Patients with Musculoskeletal Disorders (Clinical Nursing Series) [Internet]. Western Schools"},{"key":"#cr-split#-11862_CR97.2","unstructured":"[cited 2025 Dec 9]. 214 p. Available from: http:\/\/archive.org\/details\/isbn_9781578011087"},{"key":"11862_CR98","unstructured":"Escott-Stump S (2008) Nutrition and Diagnosis-related Care. Lippincott Williams & Wilkins, p 996"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11862-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11862-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11862-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:54:41Z","timestamp":1777370081000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11862-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11862"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11862-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"5 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"680"}}