{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:34:18Z","timestamp":1777368858301,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11864-1","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:36:54Z","timestamp":1777365414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strategic role of calpains in modulation of NF-\u03baB activity in skeletal muscle"],"prefix":"10.1007","volume":"53","author":[{"given":"Ritu","family":"Ladwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-5188","authenticated-orcid":false,"given":"Rajesh","family":"Dabur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"11864_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2021.140616","author":"S Spinozzi","year":"2021","unstructured":"Spinozzi S, Albini S, Best H, Richard I (2021) Calpains for dummies: what you need to know about the calpain family. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. https:\/\/doi.org\/10.1016\/j.bbapap.2021.140616","journal-title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"},{"key":"11864_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118788","author":"S Cohen","year":"2020","unstructured":"Cohen S (2020) Role of calpains in promoting desmin filaments depolymerization and muscle atrophy. Biochim Biophys Acta Mol Cell Res. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118788","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"11864_CR3","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.5036","author":"L Chen","year":"2021","unstructured":"Chen L, Tang F, Gao H, Zhang X, Li X, Xiao D (2021) CAPN3: a muscle-specific calpain with an important role in the pathogenesis of diseases (review). Int J Mol Med. https:\/\/doi.org\/10.3892\/ijmm.2021.5036","journal-title":"Int J Mol Med"},{"key":"11864_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.01.005","author":"P P\u00e1nico","year":"2014","unstructured":"P\u00e1nico P, Salazar AM, Burns AL, Ostrosky-Wegman P (2014) Role of calpain-10 in the development of diabetes mellitus and its complications. Arch Med Res. https:\/\/doi.org\/10.1016\/j.arcmed.2014.01.005","journal-title":"Arch Med Res"},{"key":"11864_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091686","author":"Y Ji","year":"2022","unstructured":"Ji Y, Li M, Chang M, Liu R, Qiu J, Wang K, Deng C, Shen Y, Zhu J, Wang W, Xu L, Sun H (2022) Inflammation: roles in skeletal muscle atrophy. Antioxidants. https:\/\/doi.org\/10.3390\/antiox11091686","journal-title":"Antioxidants"},{"key":"11864_CR6","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2020_098","author":"AO Ilhan","year":"2020","unstructured":"Ilhan AO, Ozkoc M, Ol KK, Karimkhani H, Senturk H, Burukoglu D, Kanbak G (2020) Protective effect of betaine against skeleton muscle apoptosis in rats induced by chronic alcohol and statin consumption. Bratisl Lek Listy. https:\/\/doi.org\/10.4149\/BLL_2020_098","journal-title":"Bratisl Lek Listy"},{"key":"11864_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25189793","author":"S Msweli","year":"2024","unstructured":"Msweli S, Pakala SB, Syed K (2024) NF-\u03baB transcription factors: their distribution, family expansion, structural conservation, and evolution in animals. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25189793","journal-title":"Int J Mol Sci"},{"key":"11864_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01635-4","author":"G Kannan","year":"2025","unstructured":"Kannan G, Paul BM, Thangaraj P (2025) Stimulation, regulation, and inflammaging interventions of natural compounds on Nuclear Factor Kappa B (NF-kB) pathway: a comprehensive review. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-024-01635-4","journal-title":"Inflammopharmacology"},{"key":"11864_CR9","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adh1641","author":"T Mukherjee","year":"2024","unstructured":"Mukherjee T, Kumar N, Chawla M, Philpott DJ, Basak S (2024) The NF-\u03baB signaling system in the immunopathogenesis of inflammatory bowel disease. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.adh1641","journal-title":"Sci Signal"},{"key":"11864_CR10","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2025.2451444","author":"Z Binte Hanafi","year":"2025","unstructured":"Binte Hanafi Z, Mei Y, Teo HY, Zhu Y, Yong Lionel CC, Chiu JW, Lu J, Liu H (2025) Calpain 2 regulates IL-1\u03b1 secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment. Oncoimmunology. https:\/\/doi.org\/10.1080\/2162402X.2025.2451444","journal-title":"Oncoimmunology"},{"key":"11864_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03521-9","author":"H Khan","year":"2022","unstructured":"Khan H, Garg N, Singh TG, Kaur A, Thapa K (2022) Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases. Neurochem Res. https:\/\/doi.org\/10.1007\/s11064-021-03521-9","journal-title":"Neurochem Res"},{"key":"11864_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/life12122012","author":"S Almowallad","year":"2022","unstructured":"Almowallad S, Alqahtani LS, Mobashir M (2022) NF-kB in signaling patterns and its temporal dynamics encode\/decode human diseases. Life Basel. https:\/\/doi.org\/10.3390\/life12122012","journal-title":"Life Basel"},{"key":"11864_CR13","doi-asserted-by":"publisher","DOI":"10.2174\/1874467217666230908111754","author":"SM Manohar","year":"2023","unstructured":"Manohar SM (2023) At the crossroads of TNF \u03b1 signaling and cancer. Curr Mol Pharmacol. https:\/\/doi.org\/10.2174\/1874467217666230908111754","journal-title":"Curr Mol Pharmacol"},{"key":"11864_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14320-9","author":"G Weninger","year":"2022","unstructured":"Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE (2022) Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-022-14320-9","journal-title":"Sci Rep"},{"key":"11864_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00360-2","author":"ZQ Liu","year":"1996","unstructured":"Liu ZQ, Kunimatsu M, Yang JP, Ozaki Y, Sasaki M, Okamoto T (1996) Proteolytic processing of nuclear factor \u03baB by calpain in vitro. FEBS Lett. https:\/\/doi.org\/10.1016\/0014-5793(96)00360-2","journal-title":"FEBS Lett"},{"key":"11864_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0014-5793(96)00360-2","volume":"385","author":"ZQ K.M.Y.J.O.Y.S.M.O.T. Liu","year":"1996","unstructured":"K.M.Y.J.O.Y.S.M.O.T. Liu ZQ (1996) Proteolytic processing of nuclear factor kappa B by calpain in vitro. FEBS Lett 385:109\u2013113","journal-title":"FEBS Lett"},{"key":"11864_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201471","author":"C Huguet","year":"1997","unstructured":"Huguet C, Crepieux P, Laudet V (1997) Rel\/NF-\u03baB transcription factors and I\u03baB inhibitors: evolution from a unique common ancestor. Oncogene. https:\/\/doi.org\/10.1038\/sj.onc.1201471","journal-title":"Oncogene"},{"key":"11864_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81698-0","author":"MD Jacobs","year":"1998","unstructured":"Jacobs MD, Harrison SC (1998) Structure of an I\u03baB\u03b1\/NF-\u03baB complex. Cell. https:\/\/doi.org\/10.1016\/S0092-8674(00)81698-0","journal-title":"Cell"},{"key":"11864_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.04.033","author":"OV Savinova","year":"2009","unstructured":"Savinova OV, Hoffmann A, Ghosh G (2009) The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell. https:\/\/doi.org\/10.1016\/j.molcel.2009.04.033","journal-title":"Mol Cell"},{"key":"11864_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.847699","author":"H Liu","year":"2022","unstructured":"Liu H, Zeng L, Yang Y, Guo C, Wang H (2022) Bcl-3: a double-edged sword in immune cells and inflammation. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.847699","journal-title":"Front Immunol"},{"key":"11864_CR21","doi-asserted-by":"publisher","unstructured":"Forsberg NE, Huang J (2000) Strategies for regulating calpain activities in living cells. Methods Mol Biol 144. https:\/\/doi.org\/10.1385\/1-59259-050-0:319","DOI":"10.1385\/1-59259-050-0:319"},{"key":"11864_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s001090100225","author":"S Baghdiguian","year":"2001","unstructured":"Baghdiguian S, Richard I, Martin M, Coopman P, Beckmann JS, Mangeat P, Lefranc G (2001) Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the I\u03baB\u03b1\/NF-\u03baB survival pathway in skeletal muscle. J Mol Med. https:\/\/doi.org\/10.1007\/s001090100225","journal-title":"J Mol Med"},{"key":"11864_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01098.x","author":"N Kanarek","year":"2012","unstructured":"Kanarek N, Ben-Neriah Y (2012) Regulation of NF-\u03baB by ubiquitination and degradation of the I\u03baBs. Immunol Rev. https:\/\/doi.org\/10.1111\/j.1600-065X.2012.01098.x","journal-title":"Immunol Rev"},{"key":"11864_CR24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.7.1583","author":"I Richard","year":"2000","unstructured":"Richard I, Roudaut C, Marchand S, Baghdiguian S, Herasse M, Stockholm D, Ono Y, Suel L, Bourg N, Sorimachi H, Lefranc G, Fardeau M, S\u00e9bille A, Beckmann JS (2000) Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated I\u03baB\u03b1\/nuclear factor \u03baB pathway perturbation in mice. J Cell Biol. https:\/\/doi.org\/10.1083\/jcb.151.7.1583","journal-title":"J Cell Biol"},{"key":"11864_CR25","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0132","author":"F Chen","year":"1997","unstructured":"Chen F, Lu Y, Kuhn DC, Maki M, Shi X, Sun SC, Demers LM (1997) Calpain contributes to silica-induced I\u03baB-\u03b1 degradation and nuclear factor-\u03baB activation. Arch Biochem Biophys. https:\/\/doi.org\/10.1006\/abbi.1997.0132","journal-title":"Arch Biochem Biophys"},{"key":"11864_CR26","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000026410.56000.dd","author":"K Schaecher","year":"2004","unstructured":"Schaecher K, Goust JM, Banik NL (2004) The effects of calpain inhibition on IkB\u03b1 degradation after activation of PBMCs: identification of the calpain cleavage sites. Neurochem Res. https:\/\/doi.org\/10.1023\/B:NERE.0000026410.56000.dd","journal-title":"Neurochem Res"},{"key":"11864_CR27","doi-asserted-by":"publisher","unstructured":"Krappmann D, Wulczyn FG, Scheidereit C (1996) Different mechanisms control signal-induced degradation and basal turnover of the NF-\u03baB inhibitor I\u03baB\u03b1 in vivo. EMBO J 15. https:\/\/doi.org\/10.1002\/j.1460-2075.1996.tb01061.x","DOI":"10.1002\/j.1460-2075.1996.tb01061.x"},{"key":"11864_CR28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4292","author":"S Schoonbroodt","year":"2000","unstructured":"Schoonbroodt S, Ferreira V, Best-Belpomme M, Boelaert JR, Legrand-Poels S, Korner M, Piette J (2000) Crucial role of the amino-terminal Tyrosine residue 42 and the carboxyl-terminal PEST domain of I\u03baB\u03b1 in NF-\u03baB activation by an oxidative stress. J Immunol. https:\/\/doi.org\/10.4049\/jimmunol.164.8.4292","journal-title":"J Immunol"},{"key":"11864_CR29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.4919","author":"J Shen","year":"2001","unstructured":"Shen J, Channavajhala P, Seldin DC, Sonenshein GE (2001) Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of I\u03baB\u03b1. The Journal of Immunology. https:\/\/doi.org\/10.4049\/jimmunol.167.9.4919","journal-title":"The Journal of Immunology"},{"key":"11864_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.73","author":"E Mathes","year":"2008","unstructured":"Mathes E, O\u2019Dea EL, Hoffmann A, Ghosh G (2008) NF-\u03baB dictates the degradation pathway of I\u03baB\u03b1. EMBO Journal. https:\/\/doi.org\/10.1038\/emboj.2008.73","journal-title":"EMBO Journal"},{"key":"11864_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.03.071","author":"S Kojic","year":"2004","unstructured":"Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004) The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol. https:\/\/doi.org\/10.1016\/j.jmb.2004.03.071","journal-title":"J. Mol. Biol."},{"key":"11864_CR32","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.4.793","author":"Y Zou","year":"1997","unstructured":"Zou Y, Evans S, Chen J, Kuo HC, Harvey RP, Chien KR (1997) CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development. https:\/\/doi.org\/10.1242\/dev.124.4.793","journal-title":"Development"},{"key":"11864_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.09.012","author":"MK Miller","year":"2003","unstructured":"Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S (2003) The muscle ankyrin repeat proteins: CARP, ankrd2\/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol. https:\/\/doi.org\/10.1016\/j.jmb.2003.09.012","journal-title":"J. Mol. Biol."},{"key":"11864_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07820.x","author":"L Laure","year":"2010","unstructured":"Laure L, Dani\u00e8le N, Suel L, Marchand S, Aubert S, Bourg N, Roudaut C, Duguez S, Bartoli M, Richard I (2010) A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-B pathway in skeletal muscle. FEBS Journal. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07820.x","journal-title":"FEBS Journal"},{"key":"11864_CR35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31158","author":"H Sorimachi","year":"1995","unstructured":"Sorimachi H, Kinbara K, Kimura S, Takahashi M, Ishiura S, Sasagawa N, Sorimachi N, Shimada H, Tagawa K, Maruyama K, Suzuki K (1995) Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence. Journal of Biological Chemistry. https:\/\/doi.org\/10.1074\/jbc.270.52.31158","journal-title":"Journal of Biological Chemistry"},{"key":"11864_CR36","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90660.2008","author":"M Lehti","year":"2009","unstructured":"Lehti M, Kivel\u00e4 R, Komi P, Komulainen J, Kainulainen H, Kyr\u00f6l\u00e4inen H (2009) Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains. J Appl Physiol. https:\/\/doi.org\/10.1152\/japplphysiol.90660.2008","journal-title":"J. Appl. Physiol."},{"key":"11864_CR37","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7318796","author":"V Cenni","year":"2019","unstructured":"Cenni V, Kojic S, Capanni C, Faulkner G, Lattanzi G (2019) Ankrd2 in mechanotransduction and oxidative stress response in skeletal muscle: new cues for the pathogenesis of muscular laminopathies. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/7318796","journal-title":"Oxid. Med. Cell. Longev."},{"key":"11864_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.076","author":"M Moulik","year":"2009","unstructured":"Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek AM, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA (2009) ANKRD1, the gene encoding Cardiac Ankyrin Repeat Protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. https:\/\/doi.org\/10.1016\/j.jacc.2009.02.076","journal-title":"J Am Coll Cardiol"},{"key":"11864_CR39","doi-asserted-by":"crossref","unstructured":"Liu X-H, Cardozo CP, Bauman WA (2015) Ankrd1 modulates the balance between physiological and pathological inflammation responses through feedback inhibition of NF-kb signaling activity in C2C12 myoblasts. Endocr Rev 36","DOI":"10.1016\/j.bbrc.2015.06.118"},{"key":"11864_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biology12060776","author":"D Iacobazzi","year":"2023","unstructured":"Iacobazzi D, Convertini P, Todisco S, Santarsiero A, Iacobazzi V, Infantino V (2023) New insights into NF-\u03baB signaling in innate immunity: focus on immunometabolic crosstalks. Biology Basel. https:\/\/doi.org\/10.3390\/biology12060776","journal-title":"Biology Basel"},{"key":"11864_CR41","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2221","author":"JH Park","year":"2005","unstructured":"Park JH, Liu L, Kim IH, Kim JH, You KR, Kim DG (2005) Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells. Cancer Res. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-2221","journal-title":"Cancer Res"},{"key":"11864_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-024-09671-x","author":"MA Lopez","year":"2024","unstructured":"Lopez MA, Pardo PS, Mohamed JS, Boriek AM (2024) ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NF\u03baB. J Muscle Res Cell Motil. https:\/\/doi.org\/10.1007\/s10974-024-09671-x","journal-title":"J Muscle Res Cell Motil"},{"key":"11864_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/v14020373","author":"AR Lee","year":"2022","unstructured":"Lee AR, Park YK, Dezhbord M, Kim KH (2022) Interaction between the Hepatitis B Virus and Cellular FLIP variants in viral replication and the innate immune system. Viruses. https:\/\/doi.org\/10.3390\/v14020373","journal-title":"Viruses"},{"key":"11864_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.11.015","author":"M Bagnoli","year":"2010","unstructured":"Bagnoli M, Canevari S, Mezzanzanica D (2010) Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer. Int J Biochem Cell Biol. https:\/\/doi.org\/10.1016\/j.biocel.2009.11.015","journal-title":"Int J Biochem Cell Biol"},{"key":"11864_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00986-4","author":"SH Chan","year":"2023","unstructured":"Chan SH, Kuo WH, Wang LH (2023) SCEL regulates switches between pro-survival and apoptosis of the TNF-\u03b1\/TNFR1\/NF-\u03baB\/c-FLIP axis to control lung colonization of triple negative breast cancer. J Biomed Sci. https:\/\/doi.org\/10.1186\/s12929-023-00986-4","journal-title":"J Biomed Sci"},{"key":"11864_CR46","unstructured":"Baratchian M, Davis CA, Shimizu A, Escors D, Bagneris C, Barrett T, Collins MK (2016) Distinct activation mechanisms of NF-\u03baB regulator IKK by isoforms of the cell death regulator cFLIP. J Biol Chem"},{"key":"11864_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90368-2","author":"I Richard","year":"1995","unstructured":"Richard I, Broux O, Allamand V, Fougerousse F, Chiannilkulchai N, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C, Hillaire D, Passos-Bueno MR, Zatz M, Tischfield JA, Fardeau M, Jackson CE, Cohen D, Beckmann JS (1995) Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A. Cell. https:\/\/doi.org\/10.1016\/0092-8674(95)90368-2","journal-title":"Cell"},{"key":"11864_CR48","unstructured":"Safa AR (2012) c-FLIP, a master anti-apoptotic regulator. Exp Oncol 34"},{"key":"11864_CR49","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8701com","author":"B Benayoun","year":"2008","unstructured":"Benayoun B, Baghdiguian S, Lajmanovich A, Bartoli M, Daniele N, Gicquel E, Bourg N, Raynaud F, Pasquier M, Suel L, Lochmuller H, Lefranc G, Richard I (2008) NF-NF \u2010\u03ba BB\u2010dependent expression of the antiapoptotic factor c\u2010FLIP is regulated by calpain 3, the protein involved in limb\u2010girdle muscular dystrophy type 2A. FASEB J. https:\/\/doi.org\/10.1096\/fj.07-8701com","journal-title":"FASEB J"},{"key":"11864_CR50","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10917-1","author":"AS Alhallaq","year":"2025","unstructured":"Alhallaq AS, Sultan NS (2025) Decoding NF-\u03baB: nucleocytoplasmic shuttling dynamics, synthetic modulation and post-therapeutic behavior in cancer. Mol Biol Rep. https:\/\/doi.org\/10.1007\/s11033-025-10917-1","journal-title":"Mol Biol Rep"},{"key":"11864_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401592","author":"F Demarchi","year":"2005","unstructured":"Demarchi F, Bertoli C, Greer PA, Schneider C (2005) Ceramide triggers an NF-\u03baB-dependent survival pathway through calpain. Cell Death Differ. https:\/\/doi.org\/10.1038\/sj.cdd.4401592","journal-title":"Cell Death Differ"},{"key":"11864_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.15250","author":"G Sachse","year":"2025","unstructured":"Sachse G, Tennigkeit J, Pagonas N, Hillmeister P, Buschmann I, Czolbe M, Nordbeck P, Schmitt J, Patschan D, Ritter O (2025) Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy. ESC Heart Fail. https:\/\/doi.org\/10.1002\/ehf2.15250","journal-title":"ESC Heart Fail"},{"key":"11864_CR53","doi-asserted-by":"publisher","DOI":"10.23946\/2500-0764-2023-8-2-53-66","author":"AV Meyer","year":"2023","unstructured":"Meyer AV, Ulyanova MV, Imekina DO, Padyukova AD, Tolochko TA, Astafieva EA, Lavryashina MB (2023) Analytical screening of polymorphic variants of 20S proteasome genes when planning a study of pathogenetic effects of modification of NFKB1 post-translational processing. Fundam Clin Med. https:\/\/doi.org\/10.23946\/2500-0764-2023-8-2-53-66","journal-title":"Fundam Clin Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11864-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11864-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11864-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:36:59Z","timestamp":1777365419000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11864-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11864"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11864-1","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest, financial or otherwise.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors used Grammarly\n                      \u00ae\n                      for minor language editing, including grammar, spelling, and sentence clarity. No content generation, data interpretation, or scientific conclusions were influenced by the tool.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ai"}}],"article-number":"677"}}