{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:31:39Z","timestamp":1790343099602,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Joint Council of Scientific & Industrial Research\u2013University Grants Commission (CSIR-UGC) fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11894-9","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:54:16Z","timestamp":1778504056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tunicamycin-induced ER stress promotes inflammation in SH-SY5Y cells through ROS-NF-\u03baB-SIRT1 pathway"],"prefix":"10.1007","volume":"53","author":[{"given":"Sreelekshmi","family":"G. Jayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Jayakumaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boban","family":"P.T.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"issue":"2","key":"11894_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","volume":"13","author":"C Hetz","year":"2012","unstructured":"Hetz C (2012) The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13(2):89\u2013102. https:\/\/doi.org\/10.1038\/nrm3270","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6059","key":"11894_CR2","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D (2011) The unfolded protein response: From stress pathway to homeostatic regulation. Science 334(6059):1081\u20131086. https:\/\/doi.org\/10.1126\/science.1209038","journal-title":"Science"},{"issue":"1","key":"11894_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10495-016-1296-4","volume":"22","author":"C Xiang","year":"2017","unstructured":"Xiang C, Wang Y, Zhang H, Han F (2017) The role of endoplasmic reticulum stress in neurodegenerative disease. Apoptosis 22(1):1\u201326. https:\/\/doi.org\/10.1007\/s10495-016-1296-4","journal-title":"Apoptosis"},{"issue":"7586","key":"11894_CR4","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature17041","volume":"529","author":"M Wang","year":"2016","unstructured":"Wang M, Kaufman RJ (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529(7586):326\u2013335. https:\/\/doi.org\/10.1038\/nature17041","journal-title":"Nature"},{"issue":"9","key":"11894_CR5","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1089\/ars.2009.2485","volume":"11","author":"M Wang","year":"2009","unstructured":"Wang M, Wey S, Zhang Y, Ye R, Lee AS (2009) Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal 11(9):2307\u20132316. https:\/\/doi.org\/10.1089\/ars.2009.2485","journal-title":"Antioxid Redox Signal"},{"key":"11894_CR6","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez D, Geisse A, Bernales JI, Lira A, Osorio F (2021) The unfolded protein response in immune cells as an emerging regulator of neuroinflammation. Front Aging Neurosci 13682633. https:\/\/doi.org\/10.3389\/fnagi.2021.682633","DOI":"10.3389\/fnagi.2021.682633"},{"issue":"7203","key":"11894_CR7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428\u2013435. https:\/\/doi.org\/10.1038\/nature07201","journal-title":"Nature"},{"key":"11894_CR8","doi-asserted-by":"publisher","first-page":"758311","DOI":"10.3389\/fmed.2021.758311","volume":"8","author":"S Chipurupalli","year":"2021","unstructured":"Chipurupalli S, Samavedam U, Robinson N (2021) Crosstalk between ER stress, autophagy and inflammation. Front Med 8:758311. https:\/\/doi.org\/10.3389\/fmed.2021.758311","journal-title":"Front Med"},{"issue":"1","key":"11894_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","volume":"16","author":"J Liu","year":"2023","unstructured":"Liu J, Han X, Zhang T, Tian K, Li Z, Luo F (2023) Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: From mechanism to therapy. J Hematol Oncol 16(1):116. https:\/\/doi.org\/10.1186\/s13045-023-01512-7","journal-title":"J Hematol Oncol"},{"issue":"3","key":"11894_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/antiox13030312","volume":"13","author":"Y Hong","year":"2024","unstructured":"Hong Y, Boiti A, Vallone D, Foulkes NS (2024) Reactive oxygen species signaling and oxidative stress: Transcriptional regulation and evolution. Antioxidants 13(3):312. https:\/\/doi.org\/10.3390\/antiox13030312","journal-title":"Antioxidants"},{"issue":"4","key":"11894_CR11","doi-asserted-by":"publisher","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus A, Ghosh S (2009) The NF-\u03baB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1(4):a000034. https:\/\/doi.org\/10.1101\/cshperspect.a000034","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"11894_CR12","doi-asserted-by":"publisher","first-page":"831168","DOI":"10.3389\/fimmu.2022.831168","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Huang Y, Li W, Wang Z, Xu J, Zhang Y (2022) Regulation of SIRT1 and its roles in inflammation. Front Immunol 13:831168. https:\/\/doi.org\/10.3389\/fimmu.2022.831168","journal-title":"Front Immunol"},{"issue":"9","key":"11894_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/0019-2791(71)90454-X","volume":"8","author":"E Engvall","year":"1971","unstructured":"Engvall E, Perlmann P (1971) Enzyme-linked immunosorbent assay (ELISA): Quantitative assay of immunoglobulin G. Immunochemistry 8(9):871\u2013874. https:\/\/doi.org\/10.1016\/0019-2791(71)90454-X","journal-title":"Immunochemistry"},{"issue":"1","key":"11894_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.acthis.2008.02.005","volume":"111","author":"M Orciani","year":"2009","unstructured":"Orciani M, Trubiani O, Vignini A, Mattioli-Belmonte M, Di Primio R, Salvolini E (2009) Nitric oxide production during the osteogenic differentiation of human periodontal ligament mesenchymal stem cells. Acta Histochem 111(1):15\u201324. https:\/\/doi.org\/10.1016\/j.acthis.2008.02.005","journal-title":"Acta Histochem"},{"issue":"5259","key":"11894_CR15","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680\u2013685. https:\/\/doi.org\/10.1038\/227680a0","journal-title":"Nature"},{"issue":"1","key":"11894_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neures.2007.09.005","volume":"60","author":"T Oda","year":"2008","unstructured":"Oda T, Kosuge Y, Arakawa M, Ishige K, Ito Y (2008) Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. Neurosci Res 60(1):29\u201339. https:\/\/doi.org\/10.1016\/j.neures.2007.09.005","journal-title":"Neurosci Res"},{"issue":"29","key":"11894_CR17","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.1073\/pnas.1109035108","volume":"108","author":"MC Bassik","year":"2011","unstructured":"Bassik MC, Kampmann M (2011) Knocking out the door to tunicamycin entry. Proc Natl Acad Sci USA 108(29):11731\u201311732. https:\/\/doi.org\/10.1073\/pnas.1109035108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"11894_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","volume":"26","author":"H Blaser","year":"2016","unstructured":"Blaser H, Dostert C, Mak TW, Brenner D (2016) TNF and ROS crosstalk in inflammation. Trends Cell Biol 26(4):249\u2013261. https:\/\/doi.org\/10.1016\/j.tcb.2015.12.002","journal-title":"Trends Cell Biol"},{"issue":"8","key":"11894_CR19","doi-asserted-by":"publisher","first-page":"10835","DOI":"10.1096\/fj.202000734R","volume":"34","author":"M Jiang","year":"2020","unstructured":"Jiang M, Zhang Y, Liu Y, Li X, Li J, Wang J, Chen Z (2020) Endoplasmic reticulum stress-dependent activation of iNOS\/NO\u2013NF-\u03baB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB J 34(8):10835\u201310849. https:\/\/doi.org\/10.1096\/fj.202000734R","journal-title":"FASEB J"},{"issue":"1","key":"11894_CR20","doi-asserted-by":"publisher","first-page":"9459","DOI":"10.1038\/s41598-017-09528-z","volume":"7","author":"X Kang","year":"2017","unstructured":"Kang X, Qiu Y, Liu Z, Wang Y, Zhao L, Wang J, Chen J (2017) Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep 7(1):9459. https:\/\/doi.org\/10.1038\/s41598-017-09528-z","journal-title":"Sci Rep"},{"issue":"1","key":"11894_CR21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s00018-024-05286-0","volume":"81","author":"JC Casas-Martinez","year":"2024","unstructured":"Casas-Martinez JC, Samali A, McDonagh B (2024) Redox regulation of UPR signalling and mitochondrial ER contact sites. Cell Mol Life Sci 81(1):250. https:\/\/doi.org\/10.1007\/s00018-024-05286-0","journal-title":"Cell Mol Life Sci"},{"key":"11894_CR22","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2147\/JIR.S275595","volume":"13","author":"J Checa","year":"2020","unstructured":"Checa J, Aran JM (2020) Reactive oxygen species: Drivers of physiological and pathological processes. J Inflamm Res 13:1057\u20131073. https:\/\/doi.org\/10.2147\/JIR.S275595","journal-title":"J Inflamm Res"},{"issue":"12","key":"11894_CR23","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23(12):2369\u20132380. https:\/\/doi.org\/10.1038\/sj.emboj.7600244","journal-title":"EMBO J"},{"issue":"11","key":"11894_CR24","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.3390\/ijms21113858","volume":"21","author":"E de Gregorio","year":"2020","unstructured":"de Gregorio E, Colell A, Morales A, Mar\u00ed M (2020) Relevance of SIRT1\u2013NF-\u03baB axis as therapeutic target to ameliorate inflammation in liver disease. Int J Mol Sci 21(11):3858. https:\/\/doi.org\/10.3390\/ijms21113858","journal-title":"Int J Mol Sci"},{"issue":"2","key":"11894_CR25","first-page":"541","volume":"12","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wu X, Zhang X, Chen Z, Zhang Y, Wang Y, Li J (2020) Tunicamycin induces ER stress and inhibits tumorigenesis of head and neck cancer cells by inhibiting N-glycosylation. Am J Translational Res 12(2):541\u2013550","journal-title":"Am J Translational Res"},{"issue":"12","key":"11894_CR26","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/aps.2016.75","volume":"37","author":"Z Mou","year":"2016","unstructured":"Mou Z, Yuan YH, Lou YX, Heng Y, Huang JY, Xia CY, Chen NH (2016) Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro. Acta Pharmacol Sinica 37(12):1525\u20131533. https:\/\/doi.org\/10.1038\/aps.2016.75","journal-title":"Acta Pharmacol Sinica"},{"issue":"1","key":"11894_CR27","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M, Xiong S, Xia X (2023) Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target therapy 8(1):352. https:\/\/doi.org\/10.1038\/s41392-023-01570-w","journal-title":"Signal Transduct Target therapy"},{"issue":"6","key":"11894_CR28","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140(6):900\u2013917. https:\/\/doi.org\/10.1016\/j.cell.2010.02.034","journal-title":"Cell"},{"key":"11894_CR29","doi-asserted-by":"publisher","unstructured":"Fischer R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxidative Medicine and Cellular Longevity, 2015. Article 610813 https:\/\/doi.org\/10.1155\/2015\/610813","DOI":"10.1155\/2015\/610813"},{"issue":"2","key":"11894_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/02770903.2016.1205085","volume":"54","author":"Q Guo","year":"2017","unstructured":"Guo Q, Li H, Liu J, Xu L, Yang L, Wu Y (2017) Tunicamycin aggravates endoplasmic reticulum stress and airway inflammation via PERK\u2013ATF4\u2013CHOP signaling in a murine model of neutrophilic asthma. J Asthma 54(2):125\u2013133. https:\/\/doi.org\/10.1080\/02770903.2016.1205085","journal-title":"J Asthma"},{"issue":"3","key":"11894_CR31","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1159\/000354476","volume":"32","author":"Y Chen","year":"2013","unstructured":"Chen Y, Ji Y, Jin X, Sun L, Zhang J, Chen Z (2013) ER stress activating ATF4\/CHOP\u2013TNF-\u03b1 signaling pathway contributes to alcohol-induced disruption of osteogenic lineage of multipotential mesenchymal stem cells. Cell Physiol Biochem 32(3):743\u2013754. https:\/\/doi.org\/10.1159\/000354476","journal-title":"Cell Physiol Biochem"},{"key":"11894_CR32","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2025.01.027","volume":"229","author":"L Chen","year":"2025","unstructured":"Chen L, Zhao X, Sheng R, Lazarovici P, Zheng W (2025) Artemisinin alleviates astrocyte overactivation and neuroinflammation by modulating the IRE1\/NF-\u03baB signaling pathway in in vitro and in vivo Alzheimer\u2019s disease models. Free Radic Biol Med 229:96\u2013110. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.01.027","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"11894_CR33","doi-asserted-by":"publisher","first-page":"101402","DOI":"10.1016\/j.jcmgh.2024.101402","volume":"18","author":"J Rao","year":"2024","unstructured":"Rao J, Liu Y, Zhang J, Wang L, Li X, Chen Z (2024) XBP1 facilitating NF-\u03baB-p65 nuclear translocation promotes macrophage-originated sterile inflammation via regulating MT2 transcription in the ischemia\/reperfusion liver. Cell Mol Gastroenterol Hepatol 18(6):101402. https:\/\/doi.org\/10.1016\/j.jcmgh.2024.101402","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"4","key":"11894_CR34","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1053\/j.gastro.2020.06.088","volume":"159","author":"ST Stengel","year":"2020","unstructured":"Stengel ST, Fazio A, Lipinski S, Jahnke A, Spalinger MR, Kasper S, Rogler G (2020) Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress. Gastroenterology 159(4):1357\u20131374e10. https:\/\/doi.org\/10.1053\/j.gastro.2020.06.088","journal-title":"Gastroenterology"},{"issue":"7203","key":"11894_CR35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454(7203):455\u2013462. https:\/\/doi.org\/10.1038\/nature07203","journal-title":"Nature"},{"key":"11894_CR36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mad.2017.04.001","volume":"164","author":"C Nopparat","year":"2017","unstructured":"Nopparat C, Chantadul V, Permpoonputtana K, Govitrapong P (2017) The anti-inflammatory effect of melatonin in SH-SY5Y neuroblastoma cells exposed to sublethal dose of hydrogen peroxide. Mech Ageing Dev 164:49\u201360. https:\/\/doi.org\/10.1016\/j.mad.2017.04.001","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"11894_CR37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/cr.2010.178","volume":"21","author":"MJ Morgan","year":"2011","unstructured":"Morgan MJ, Liu Z (2011) Crosstalk of reactive oxygen species and NF-\u03baB signaling. Cell Res 21(1):103\u2013115. https:\/\/doi.org\/10.1038\/cr.2010.178","journal-title":"Cell Res"},{"key":"11894_CR38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fphys.2018.00065","volume":"9","author":"R Sandoval","year":"2018","unstructured":"Sandoval R, Lazcano P, Ferrari F, Pinto-Pardo N, Gonz\u00e1lez-Billault C, Utreras E (2018) TNF-\u03b1 increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons. Front Physiol 9:65. https:\/\/doi.org\/10.3389\/fphys.2018.00065","journal-title":"Front Physiol"},{"issue":"4","key":"11894_CR39","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/BSR20090048","volume":"30","author":"K Zhao","year":"2010","unstructured":"Zhao K, Huang Z, Lu H, Zhou J, Wei T (2010) Induction of inducible nitric oxide synthase increases the production of reactive oxygen species in RAW264.7 macrophages. Biosci Rep 30(4):233\u2013241. https:\/\/doi.org\/10.1042\/BSR20090048","journal-title":"Biosci Rep"},{"issue":"9","key":"11894_CR40","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1111\/jcmm.12893","volume":"20","author":"C Chan","year":"2016","unstructured":"Chan C, Cheung Y, Chen Y, Li Y, Lau A (2016) Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction. J Cell Mol Med 20(9):1749\u20131760. https:\/\/doi.org\/10.1111\/jcmm.12893","journal-title":"J Cell Mol Med"},{"issue":"2","key":"11894_CR41","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbrc.2015.10.007","volume":"467","author":"J Liu","year":"2015","unstructured":"Liu J, Du L (2015) PERK pathway is involved in oxygen\u2013glucose\u2013serum deprivation-induced NF-\u03baB activation via ROS generation in spinal cord astrocytes. Biochem Biophys Res Commun 467(2):197\u2013203. https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.007","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"11894_CR42","doi-asserted-by":"publisher","first-page":"e77228","DOI":"10.1371\/journal.pone.0077228","volume":"8","author":"E Panzhinskiy","year":"2013","unstructured":"Panzhinskiy E, Ren J, Nair S (2013) Protein tyrosine phosphatase 1B and insulin resistance: Role of endoplasmic reticulum stress\/reactive oxygen species\/nuclear factor kappa B axis. PLoS ONE 8(10):e77228. https:\/\/doi.org\/10.1371\/journal.pone.0077228","journal-title":"PLoS ONE"},{"issue":"3","key":"11894_CR43","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.bbrc.2010.05.160","volume":"397","author":"HN Zhang","year":"2010","unstructured":"Zhang HN, Li L, Gao P, Chen HZ, Zhang R, Wei YS, Liang CC (2010) Involvement of the p65\/RelA subunit of NF-\u03baB in TNF-\u03b1-induced SIRT1 expression in vascular smooth muscle cells. Biochem Biophys Res Commun 397(3):569\u2013575. https:\/\/doi.org\/10.1016\/j.bbrc.2010.05.160","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"11894_CR44","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s12192-019-01012-z","volume":"24","author":"J Lee","year":"2019","unstructured":"Lee J, Kim S, Park H, Kim Y, Lee J (2019) Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells. Cell Stress Chaperones 24(4):825\u2013833. https:\/\/doi.org\/10.1007\/s12192-019-01012-z","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"11894_CR45","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1096\/fj.10-173492","volume":"25","author":"Y Li","year":"2011","unstructured":"Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Puigserver P (2011) Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J 25(5):1664\u20131679. https:\/\/doi.org\/10.1096\/fj.10-173492","journal-title":"FASEB J"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11894-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11894-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11894-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:54:17Z","timestamp":1778504057000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11894-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11894"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11894-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"28 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This cell line-based study was exempt from ethics approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Competing interests"}}],"article-number":"740"}}