{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:16:10Z","timestamp":1788347770287,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["BT\/PR45460\/MED\/12\/952\/2022"],"award-info":[{"award-number":["BT\/PR45460\/MED\/12\/952\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-11906-8","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:59:45Z","timestamp":1778500785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrative approach for delineating structural variants using optical genome mapping and long-read genome sequencing"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-5212","authenticated-orcid":false,"given":"Usha R.","family":"Dutta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Ramgopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Divya","family":"Bhanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajitha","family":"Ponnala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani","family":"Sirineni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Vasantha","family":"Rani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"11906_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nrg.2016.49","volume":"17","author":"S Goodwin","year":"2016","unstructured":"Goodwin S, McPherson JD, McCombie WR (2016) Coming of age: ten years of next-generation sequencing technologies. Nat Rev Genet 17:333\u2013351. https:\/\/doi.org\/10.1038\/nrg.2016.49","journal-title":"Nat Rev Genet"},{"key":"11906_CR2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0140-6736(19)31140-7","volume":"10","author":"TA Manolio","year":"2019","unstructured":"Manolio TA, Rowley R, Williams MS et (2019) Opportunities, resources, and techniques for implementing genomics in clinical care. Lancet 10:511\u2013520. https:\/\/doi.org\/10.1016\/S0140-6736(19)31140-7","journal-title":"Lancet"},{"key":"11906_CR3","doi-asserted-by":"publisher","first-page":"a036269","DOI":"10.1101\/cshperspect.a036269","volume":"3","author":"ER Mardis","year":"2019","unstructured":"Mardis ER (2019) The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic. Cold Spring Harb Perspect Med 3:a036269. https:\/\/doi.org\/10.1101\/cshperspect.a036269","journal-title":"Cold Spring Harb Perspect Med"},{"key":"11906_CR4","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1056\/NEJMsr1813907","volume":"26","author":"GL Armstrong","year":"2019","unstructured":"Armstrong GL, MacCannell DR, Taylor J et al (2019) Pathogen genomics in public health. N Engl J Med 26:2569\u20132580. https:\/\/doi.org\/10.1056\/NEJMsr1813907","journal-title":"N Engl J Med"},{"key":"11906_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nrg2958","volume":"12","author":"C Alkan","year":"2011","unstructured":"Alkan C, Coe BP, Eichler EE (2011) Genome structural variation discovery and genotyping. Nat Rev Genet 12:363\u2013376. https:\/\/doi.org\/10.1038\/nrg2958","journal-title":"Nat Rev Genet"},{"key":"11906_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrg2626","volume":"11","author":"ML Metzker","year":"2010","unstructured":"Metzker ML (2010) Sequencing technologies - the next generation. Nat Rev Genet 11:31\u201346. https:\/\/doi.org\/10.1038\/nrg2626","journal-title":"Nat Rev Genet"},{"key":"11906_CR7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41576-018-0003-4","volume":"19","author":"FJ Sedlazeck","year":"2018","unstructured":"Sedlazeck FJ, Lee H, Darby CA et al (2018) Piercing the dark matter: bioinformatics of long-range sequencing and mapping. Nat Rev Genet 19:329\u2013346. https:\/\/doi.org\/10.1038\/s41576-018-0003-4","journal-title":"Nat Rev Genet"},{"key":"11906_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrg3373","volume":"14","author":"J Weischenfeldt","year":"2013","unstructured":"Weischenfeldt J, Symmons O, Spitz F et al (2013) Phenotypic impact of genomic structural variation: insights from and for human disease. Nat Rev Genet 14:125\u2013138. https:\/\/doi.org\/10.1038\/nrg3373","journal-title":"Nat Rev Genet"},{"key":"11906_CR9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/s41576-018-0007-0","volume":"19","author":"M Spielmann","year":"2018","unstructured":"Spielmann M, Lupi\u00e1\u00f1ez DG, Mundlos S (2018) Structural variation in the 3D genome. Nat Rev Genet 19:453\u2013467. https:\/\/doi.org\/10.1038\/s41576-018-0007-0","journal-title":"Nat Rev Genet"},{"key":"11906_CR10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/bip.21579","volume":"95","author":"RK Neely","year":"2011","unstructured":"Neely RK, Deen J, Hofkens J (2011) Optical mapping of DNA: single-molecule-based methods for mapping genomes. Biopolymers 95:298\u2013311. https:\/\/doi.org\/10.1002\/bip.21579","journal-title":"Biopolymers"},{"key":"11906_CR11","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3389\/fgene.2019.00426","volume":"10","author":"T Mantere","year":"2019","unstructured":"Mantere T, Kersten S, Hoischen A (2019) Long-read sequencing emerging in medical genetics. Front Genet 10:426. https:\/\/doi.org\/10.3389\/fgene.2019.00426","journal-title":"Front Genet"},{"key":"11906_CR12","doi-asserted-by":"publisher","unstructured":"de Ten E, Ameur A, Bunikis I et al (2024) Long-read sequencing and optical mapping generate near T2T assemblies that resolve a centromeric translocation. Sci Rep 18:9000. https:\/\/doi.org\/10.1038\/s41598-024-59683-3","DOI":"10.1038\/s41598-024-59683-3"},{"key":"11906_CR13","doi-asserted-by":"publisher","first-page":"29142","DOI":"10.1038\/s41598-024-80068-z","volume":"14","author":"G De Clercq","year":"2024","unstructured":"De Clercq G, Vantomme L, Dewaele B et al (2024) Full characterization of unresolved structural variation through long-read sequencing and optical genome mapping. Sci Rep 14:29142. https:\/\/doi.org\/10.1038\/s41598-024-80068-z","journal-title":"Sci Rep"},{"key":"11906_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3390\/jpm14030291","volume":"9","author":"L Budurlean","year":"2024","unstructured":"Budurlean L, Tukaramrao DB, Zhang L et al (2024) Integrating optical genome mapping and whole genome sequencing in somatic structural variant detection. J Pers Med 9:291. https:\/\/doi.org\/10.3390\/jpm14030291","journal-title":"J Pers Med"},{"key":"11906_CR15","doi-asserted-by":"publisher","first-page":"e63818","DOI":"10.1002\/ajmg.a.63818","volume":"194","author":"KL Sund","year":"2024","unstructured":"Sund KL, Liu J, Lee J et al (2024) Long-read sequencing and optical genome mapping identify causative gene disruptions in noncoding sequence in two patients with neurologic disease and known chromosome abnormalities. Am J Med Genet A 194:e63818. https:\/\/doi.org\/10.1002\/ajmg.a.63818","journal-title":"Am J Med Genet A"},{"key":"11906_CR16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1097\/GIM.0b013e3182217a3a","volume":"13","author":"H Kearney","year":"2011","unstructured":"Kearney H, Thorland E, Brown K et al (2011) American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants. Genet Med 13:680\u2013685. https:\/\/doi.org\/10.1097\/GIM.0b013e3182217a3a","journal-title":"Genet Med"},{"key":"11906_CR17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41436-019-0686-8","volume":"22","author":"ER Riggs","year":"2020","unstructured":"Riggs ER, Andersen EF, Cherry AM et al (2020) Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med 22:245\u2013257. https:\/\/doi.org\/10.1038\/s41436-019-0686-8","journal-title":"Genet Med"},{"key":"11906_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13073-023-01183-6","volume":"15","author":"E Kucuk","year":"2023","unstructured":"Kucuk E, van der Sanden BPGH, O\u2019Gorman L et al (2023) Comprehensive de novo mutation discovery with HiFi long-read sequencing. Genome Med 15:34. https:\/\/doi.org\/10.1186\/s13073-023-01183-6","journal-title":"Genome Med"},{"key":"11906_CR19","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s41587-019-0217-9","volume":"37","author":"AM Wenger","year":"2019","unstructured":"Wenger AM, Peluso P, Rowell WJ et al (2019) Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome. Nat Biotechnol 37:1155\u20131162. https:\/\/doi.org\/10.1038\/s41587-019-0217-9","journal-title":"Nat Biotechnol"},{"key":"11906_CR20","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","volume":"14","author":"H Thorvaldsd\u00f3ttir","year":"2013","unstructured":"Thorvaldsd\u00f3ttir H, Robinson JT, Mesirov JP (2013) Integrative genomics viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform 14:178\u2013192. https:\/\/doi.org\/10.1093\/bib\/bbs017","journal-title":"Brief Bioinform"},{"key":"11906_CR21","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1093\/bioinformatics\/btu555","volume":"30","author":"NJ Loman","year":"2014","unstructured":"Loman NJ, Quinlan AR (2014) Poretools: a toolkit for analyzing nanopore sequence data. Bioinformatics 30:3399\u20133401. https:\/\/doi.org\/10.1093\/bioinformatics\/btu555","journal-title":"Bioinformatics"},{"key":"11906_CR22","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1093\/bioinformatics\/bty191","volume":"34","author":"H Li","year":"2018","unstructured":"Li H (2018) Minimap2: pairwise alignment for nucleotide sequences. Bioinformatics 34:3094\u20133100. https:\/\/doi.org\/10.1093\/bioinformatics\/bty191","journal-title":"Bioinformatics"},{"key":"11906_CR23","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/bioinformatics\/btv566","volume":"15","author":"K Okonechnikov","year":"2015","unstructured":"Okonechnikov K, Conesa A, Garc\u00eda-Alcalde F (2015) Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data. Bioinformatics 15:292\u2013294. https:\/\/doi.org\/10.1093\/bioinformatics\/btv566","journal-title":"Bioinformatics"},{"key":"11906_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13059-020-02107","volume":"21","author":"T Jiang","year":"2020","unstructured":"Jiang T, Liu Y, Jiang Y et al (2020) Long-read-based human genomic structural variation detection with cuteSV. Genome Biol 21:189. https:\/\/doi.org\/10.1186\/s13059-020-02107","journal-title":"Genome Biol"},{"key":"11906_CR25","doi-asserted-by":"publisher","unstructured":"Smolka M, Paulin LF, Grochowski CM et al (2024) Detection of mosaic and population-level structural variants with Sniffles2. Nature Biotechnology 2024;42(10):1571\u20131580. https:\/\/doi.org\/10.1038\/s41587-023-02024-y","DOI":"10.1038\/s41587-023-02024-y"},{"key":"11906_CR26","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1093\/bioinformatics\/btz041","volume":"35","author":"D Heller","year":"2019","unstructured":"Heller D, Vingron M (2019) SVIM: structural variant identification using mapped long reads. Bioinformatics 35:2907\u20132915. https:\/\/doi.org\/10.1093\/bioinformatics\/btz041","journal-title":"Bioinformatics"},{"key":"11906_CR27","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1093\/bioinformatics\/bty304","volume":"34","author":"V Geoffroy","year":"2018","unstructured":"Geoffroy V, Herenger Y, Kress A et al (2018) AnnotSV: an integrated tool for structural variations annotation. Bioinformatics 34:3572\u20133574. https:\/\/doi.org\/10.1093\/bioinformatics\/bty304","journal-title":"Bioinformatics"},{"key":"11906_CR28","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/sj.onc.1202287","volume":"18","author":"K Wimmer","year":"1999","unstructured":"Wimmer K, Zhu XX, Lamb BJ et al (1999) Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma. Oncogene 18:233\u2013238. https:\/\/doi.org\/10.1038\/sj.onc.1202287","journal-title":"Oncogene"},{"key":"11906_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1042\/BJ20081736","volume":"418","author":"SE Flowerdew","year":"2009","unstructured":"Flowerdew SE, Burgoyne RD (2009) A VAMP7\/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. Biochem 418:529\u2013540. https:\/\/doi.org\/10.1042\/BJ20081736","journal-title":"Biochem"},{"key":"11906_CR30","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/s41431-024-01637-4","volume":"32","author":"G Demidov","year":"2025","unstructured":"Demidov G, Laurie S, Torella A et al (2025) Structural variant calling and clinical interpretation in 6224 unsolved rare disease exomes. Eur J Hum Genet 32:998\u20131004. https:\/\/doi.org\/10.1038\/s41431-024-01637-4","journal-title":"Eur J Hum Genet"},{"key":"11906_CR31","doi-asserted-by":"publisher","first-page":"11239","DOI":"10.1038\/s41598-024-62009-y","volume":"14","author":"I Schrauwen","year":"2024","unstructured":"Schrauwen I, Rajendran Y, Acharya A et al (2024) Optical genome mapping unveils hidden structural variants in neurodevelopmental disorders. Sci Rep 14:11239. https:\/\/doi.org\/10.1038\/s41598-024-62009-y","journal-title":"Sci Rep"},{"key":"11906_CR32","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.3390\/biomedicines12081659","volume":"12","author":"H Singh","year":"2024","unstructured":"Singh H, Sahajpal NS, Mondal AK et al (2024) Clinical Utility of Optical Genome Mapping for Improved Cytogenomic Analysis of Gliomas. Biomedicines 12:1659. https:\/\/doi.org\/10.3390\/biomedicines12081659","journal-title":"Biomedicines"},{"key":"11906_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13039-023-00636-2","volume":"16","author":"S Shi","year":"2023","unstructured":"Shi S, Huang P, Yan R et al (2023) Identification of complex and cryptic chromosomal rearrangements by optical genome mapping. Mol Cytogenet 16:5. https:\/\/doi.org\/10.1186\/s13039-023-00636-2","journal-title":"Mol Cytogenet"},{"key":"11906_CR34","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1101\/gr.279510.124","volume":"34","author":"J Eisfeldt","year":"2024","unstructured":"Eisfeldt J, Ameur A, Lenner F et al (2024) A national long-read sequencing study on chromosomal rearrangements uncovers hidden complexities. Genome Res 34:1774\u20131784. https:\/\/doi.org\/10.1101\/gr.279510.124","journal-title":"Genome Res"},{"key":"11906_CR35","doi-asserted-by":"publisher","first-page":"qzaf003","DOI":"10.1093\/gpbjnl\/qzaf003","volume":"23","author":"B Wang","year":"2025","unstructured":"Wang B, Jia P, Gao S et al (2025) Long and accurate: How HiFi sequencing is transforming genomics. Genomics Proteom Bioinf 23:qzaf003. https:\/\/doi.org\/10.1093\/gpbjnl\/qzaf003","journal-title":"Genomics Proteom Bioinf"},{"key":"11906_CR36","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.3390\/ijms26072850","volume":"26","author":"EN de Boer","year":"2025","unstructured":"de Boer EN, Scheper AJ, Hendriksen D et al (2025) Nanopore long-read sequencing as a first-tier diagnostic test to detect repeat expansions in neurological disorders. Int J Mol Sci 26:2850. https:\/\/doi.org\/10.3390\/ijms26072850","journal-title":"Int J Mol Sci"},{"key":"11906_CR37","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1002\/humu.24105","volume":"41","author":"M Pettersson","year":"2020","unstructured":"Pettersson M, Grochowski CM, Wincent J et al (2020) Cytogenetically visible inversions are formed by multiple molecular mechanisms. Hum Mutat 41:1979\u20131998. https:\/\/doi.org\/10.1002\/humu.24105","journal-title":"Hum Mutat"},{"key":"11906_CR38","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1101\/gr.279346.124","volume":"20","author":"K Bilgrav Saether","year":"2024","unstructured":"Bilgrav Saether K, Eisfeldt J, Bengtsson JD et al (2024) Leveraging the T2T assembly to resolve rare and pathogenic inversions in reference genome gaps. Genome Res 20:34:1785\u20131797. https:\/\/doi.org\/10.1101\/gr.279346.124","journal-title":"Genome Res"},{"key":"11906_CR39","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3390\/genes16080924","volume":"16","author":"B Levy","year":"2025","unstructured":"Levy B, Burnside RD, Akkari Y (2025) Optical genome mapping: A new tool for cytogenomic analysis. Genes (Basel) 16:924. https:\/\/doi.org\/10.3390\/genes16080924","journal-title":"Genes (Basel)"},{"key":"11906_CR40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nrg.2015.25","volume":"17","author":"CMB Carvalho","year":"2016","unstructured":"Carvalho CMB, Lupski JR (2016) Mechanisms underlying structural variant formation in genomic disorders. Nat Rev Genet 17:224\u2013238. https:\/\/doi.org\/10.1038\/nrg.2015.25","journal-title":"Nat Rev Genet"},{"key":"11906_CR41","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.tig.2022.06.003","volume":"38","author":"J Schuy","year":"2022","unstructured":"Schuy J, Grochowski CM, Carvalho CMB et al (2022) Complex genomic rearrangements: an underestimated cause of rare diseases. Trends Genet 38:1134\u20131146. https:\/\/doi.org\/10.1016\/j.tig.2022.06.003","journal-title":"Trends Genet"},{"key":"11906_CR42","doi-asserted-by":"publisher","first-page":"100590","DOI":"10.1016\/j.xgen.2024.100590","volume":"4","author":"CM Grochowski","year":"2024","unstructured":"Grochowski CM, Bengtsson JD, Du H et al (2024) Inverted triplications formed by iterative template switches generate structural variant diversity at genomic disorder loci. Cell Genomics 4:100590. https:\/\/doi.org\/10.1016\/j.xgen.2024.100590","journal-title":"Cell Genomics"},{"key":"11906_CR43","doi-asserted-by":"publisher","first-page":"1374860","DOI":"10.3389\/fgene.2024.1374860","volume":"15","author":"G Olivucci","year":"2024","unstructured":"Olivucci G, Iovino E, Innella G et al (2024) Long read sequencing on its way to the routine diagnostics of genetic diseases. Front Genet 15:1374860. https:\/\/doi.org\/10.3389\/fgene.2024.1374860","journal-title":"Front Genet"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11906-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-11906-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-11906-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:59:46Z","timestamp":1778500786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-11906-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11906"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-11906-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institute Bio-ethical Committee (IEC 40\/2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study, and written informed consent was obtained from parents.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent to participate"}},{"value":"No personal images of the patients were used in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent to publish"}}],"article-number":"735"}}