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Accounting for approximately 60% of cases, the behavioral variant (bvFTD) represents the most common clinical presentation of FTD. MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation and are expressed in various biological fluids. Considering bvFTD as an inflammatory disorder, this study investigated the expression of inflammation-related miRNAs in individuals with bvFTD compared with age- and sex-matched cognitively healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty patients with bvFTD and 20 cognitively healthy controls, matched for age and sex, were included in the study. Serum levels of miRNA-30c-5p and miRNA-125a-5p were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>miRNA-125a-5p expression was upregulated in individuals with bvFTD compared with controls (fold change\u2009=\u20092.02). No significant differences between groups were observed for miRNA-30c-5p. An inverse correlation was identified between miRNA-125a-5p expression and age within the bvFTD group. Pathway enrichment analysis revealed that miRNA-125a-5p was significantly involved in the regulation of genes associated with insulin receptor signaling, SUMOylation, SUMO E3 ligase\u2013mediated protein modification, SUMOylation of chromatin organization proteins, estrogen-dependent gene expression, extracellular exosome pathways, neuron migration, microtubule dynamics, and nervous system development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that miRNA-125a-5p may play an important role in FTD-related biological pathways, underscoring its potential as a molecular marker in the pathophysiology of this disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-026-11965-x","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:39:27Z","timestamp":1780475967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological pathways related to mirna-125a-5p in behavioral variant of frontotemporal dementia"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5538-5725","authenticated-orcid":false,"given":"Jessica Diniz","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5628-4532","authenticated-orcid":false,"given":"Leticia Moreira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1996-7816","authenticated-orcid":false,"given":"Mhai","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-3707","authenticated-orcid":false,"given":"J\u00e9ssica Abdo Gon\u00e7alves","family":"Tosatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7807-8882","authenticated-orcid":false,"given":"Stephanny Pinto Oliveira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7237-8013","authenticated-orcid":false,"given":"Isabela Resende","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2356-2951","authenticated-orcid":false,"given":"Vinicius Ribeiro","family":"Jeunon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-3302","authenticated-orcid":false,"given":"Maria","family":"das Gra\u00e7as Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-1205","authenticated-orcid":false,"given":"Elisa","family":"de Paula Fran\u00e7a Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-9013","authenticated-orcid":false,"given":"Leonardo Cruz","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-6990","authenticated-orcid":false,"given":"Paulo","family":"Caramelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-2063","authenticated-orcid":false,"given":"Karina Braga","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"11965_CR1","doi-asserted-by":"publisher","first-page":"1737468","DOI":"10.3389\/fneur.2025.1737468","volume":"16","author":"RK Yashooa","year":"2026","unstructured":"Yashooa RK, Nabi AQ, Smail SW, Azeez SS, Nooh WA, Mustafa SA, Al-Farha AA-B, Capitanio N, Shekha MS (2026) CRISPR\u2013Cas technologies in neurodegenerative disorders: mechanistic insights, therapeutic potential, and translational challenges. 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