{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:28:03Z","timestamp":1793237283155,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The authors thank the Deanship of Graduate Studies and Scientific Research at Jouf University f","award":["DGSSR-2024-01-02023)"],"award-info":[{"award-number":["DGSSR-2024-01-02023)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12004-5","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:26:43Z","timestamp":1779445603000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diacerein mitigates cisplatin-induced testicular toxicity in rats; Role of Nrf2\/ HO-1, NF-\u03baB\/caspase-3 and NLRP3\/ASC\/Caspase-1 signaling pathways"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-4726","authenticated-orcid":false,"given":"Gellan Alaa Mohamed","family":"Kamel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"12004_CR1","doi-asserted-by":"publisher","first-page":"127489","DOI":"10.1016\/j.jtemb.2024.127489","volume":"85","author":"RE Akhigbe","year":"2024","unstructured":"Akhigbe RE, Adelowo OE, Ajani EO, Oyesetan RI, Oladapo DD, Akhigbe TM (2024) Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2\/HO-1 and TLR4\/NF-kB signaling. J Trace Elem Med Biol 85:127489. https:\/\/doi.org\/10.1016\/j.jtemb.2024.127489","journal-title":"J Trace Elem Med Biol"},{"key":"12004_CR2","doi-asserted-by":"publisher","unstructured":"Hosney SN, Matouk AI, Ali FE, Heeba GH (2026) Morin hydrate alleviated cisplatin-induced testicular toxicity in rats via modulating NLRP3\/NF-\u03baB pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. 399(6):8363\u201379. https:\/\/doi.org\/10.1007\/s00210-025-04867-5","DOI":"10.1007\/s00210-025-04867-5"},{"key":"12004_CR3","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1007\/s43032-024-01567-y","volume":"31","author":"T Yal\u00e7\u0131n","year":"2024","unstructured":"Yal\u00e7\u0131n T, Kaya S, Yi\u011fin A, A\u011fca CA, \u00d6zdemir D, Kulo\u011flu T, Boydak M (2024) The Effect of Thymoquinone on the TNF-\u03b1\/OTULIN\/NF-\u03baB Axis Against Cisplatin-\u0130nduced Testicular Tissue Damage. Reprod Sci 31:2433\u20132446","journal-title":"Reprod Sci"},{"key":"12004_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00580-022-03369-7","volume":"31","author":"GA Mohamed Kamel","year":"2022","unstructured":"Mohamed Kamel GA, Harahsheh E, Hussein S (2022) Mechanisms underlying the hepatoprotective effect of silymarin on fluoxetine-induced liver injury in rats: the implication of peroxisome proliferator\u2013activated receptor-gamma (PPAR-\u03b3). Comp Clin Path 31:689\u2013698. https:\/\/doi.org\/10.1007\/s00580-022-03369-7","journal-title":"Comp Clin Path"},{"key":"12004_CR5","doi-asserted-by":"publisher","first-page":"103085","DOI":"10.1016\/j.tice.2025.103085","volume":"97","author":"K Rahimi","year":"2025","unstructured":"Rahimi K, Rezaie A, Javadi A, Khademi Kalantari M, Eftekhar N, Shushtari H (2025) The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats. Tissue Cell 97:103085. https:\/\/doi.org\/10.1016\/j.tice.2025.103085","journal-title":"Tissue Cell"},{"key":"12004_CR6","doi-asserted-by":"crossref","unstructured":"Cheng G, Li Z, Zhang L, Wu B (2025) Diacerein ameliorates acute urarthritis in rats through the Nrf-2\/HO-1 and NF-\u03baB pathways, Inflammopharmacology 1\u20139","DOI":"10.1007\/s10787-025-02059-4"},{"key":"12004_CR7","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1007\/s00210-023-02876-w","volume":"397","author":"MA Abdel-Reheim","year":"2024","unstructured":"Abdel-Reheim MA, Ali GF, Hassanein EHM, Mohamed WR (2024) Role of Nrf2\/HO-1, PPAR-\u03b3, and cytoglobin signals in the pathogenesis of methotrexate-induced testicular intoxication in rats and the protective effect of diacerein, Naunyn. Schmiedebergs Arch Pharmacol 397:4235\u20134246","journal-title":"Schmiedebergs Arch Pharmacol"},{"key":"12004_CR8","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1016\/j.sjbs.2021.08.025","volume":"28","author":"N Barakat","year":"2021","unstructured":"Barakat N, Barakat LAA, Zakaria MM, Khirallah SM (2021) Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2\/Ho-1 pathway and Bax down-regulation. Saudi J Biol Sci 28:7219\u20137226. https:\/\/doi.org\/10.1016\/j.sjbs.2021.08.025","journal-title":"Saudi J Biol Sci"},{"key":"12004_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3390\/antiox13040493","volume":"13","author":"RM El-Gohary","year":"2024","unstructured":"El-Gohary RM, Okasha AH, Abd El-Azeem AH, Abdel Ghafar MT, Ibrahim S, Hegab II, Farghal EE, Shalaby SAF, Elshora OA, ElMehy AE (2024) Uncovering the cardioprotective potential of Diacerein in doxorubicin cardiotoxicity: mitigating ferritinophagy-mediated ferroptosis via upregulating NRF2\/SLC7A11\/GPX4 Axis. Antioxidants 13:493","journal-title":"Antioxidants"},{"key":"12004_CR10","doi-asserted-by":"crossref","unstructured":"Refaie MM, Majeed NA, Shehata S, Muhammed AA, Hassan SM, Sherkawy HS, Ali FF, Saad MR, Mohsen M, Elsaghir SM, Fathy E (2026) Amelioration of intestinal ischemia reperfusion injury by diacerein via regulation of inflammasome\/caspase-1\/IL-1\u03b2 and Wnt\/\u03b2-catenin pathways in juvenile rats. Naunyn-schmiedeberg's Archives of Pharmacology. 399(2):2855\u201370.","DOI":"10.1007\/s00210-025-04581-2"},{"key":"12004_CR11","doi-asserted-by":"publisher","first-page":"152528","DOI":"10.1016\/j.tox.2020.152528","volume":"441","author":"VU Nna","year":"2020","unstructured":"Nna VU, Ujah GA, Suleiman JB, Mohamed M, Nwokocha C, Akpan TJ, Ekuma HC, Fubara VV, Kekung-Asu CB, Osim EE (2020) Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis. Toxicology 441:152528","journal-title":"Toxicology"},{"key":"12004_CR12","doi-asserted-by":"publisher","first-page":"103334","DOI":"10.1016\/j.etap.2020.103334","volume":"76","author":"KM Saad","year":"2020","unstructured":"Saad KM, Abdelrahman RS, Said E (2020) Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: Role of JNK\/caspase-3 signaling inhibition. Environ Toxicol Pharmacol 76:103334. https:\/\/doi.org\/10.1016\/j.etap.2020.103334","journal-title":"Environ Toxicol Pharmacol"},{"key":"12004_CR13","unstructured":"Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier health sciences"},{"key":"12004_CR14","doi-asserted-by":"crossref","unstructured":"Ardabili SO, Ahmadi S, Salimnejad R, Alipanah-Moghadam R, Jeddi F, Feizpoor S, Ahmadnia F (2025) Antioxidant and Cytoprotective Effects of Biosynthesized Zinc Oxide Nanoparticles by Nigella sativa Against Cisplatin-Induced Testicular Damage in Mice, Andrologia (2025) 4634357","DOI":"10.1155\/and\/4634357"},{"key":"12004_CR15","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1111\/andr.13078","volume":"9","author":"A Amiri","year":"2021","unstructured":"Amiri A, Chovanec M, Oliva V, Sedliak M, Mego M, Ukropec J, Ukropcov\u00e1 B (2021) Chemotherapy-induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise. Andrology 9:1879\u20131892","journal-title":"Andrology"},{"key":"12004_CR16","doi-asserted-by":"publisher","first-page":"153788","DOI":"10.1016\/j.tox.2024.153788","volume":"504","author":"A Hokmabadi","year":"2024","unstructured":"Hokmabadi A, Ranjbar E, Alipour F, Ebrahimzadeh-Bideskan A, Afshari JT, Rezaei MM, Shafieian R (2024) Protective effect of dental pulp stem cells\u2019 conditioned medium against cisplatin-induced testicular damage in rats. Toxicology 504:153788. https:\/\/doi.org\/10.1016\/j.tox.2024.153788","journal-title":"Toxicology"},{"key":"12004_CR17","doi-asserted-by":"publisher","first-page":"22720","DOI":"10.1038\/s41598-025-08235-4","volume":"15","author":"Y Mahran","year":"2025","unstructured":"Mahran Y, Badr AM, Aloyouni S, Alkahtani MM, Sarawi WS, Ali R, Alsultan D, Almufadhili S, Almasud DH, Hasan IH (2025) Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes\u2019 expression and upregulating Nrf2\/Heme oxygenase-1. Sci Rep 15:22720. https:\/\/doi.org\/10.1038\/s41598-025-08235-4","journal-title":"Sci Rep"},{"key":"12004_CR18","doi-asserted-by":"publisher","first-page":"116797","DOI":"10.1016\/j.biopha.2024.116797","volume":"175","author":"S Mohtadi","year":"2024","unstructured":"Mohtadi S, Salehcheh M, Tabandeh MR, Khorsandi L, Khodayar MJ (2024) Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-\u03baB\/NLRP3\/Caspase-1 and Bax\/Bcl2\/Caspase-3 signaling pathways. Biomed Pharmacother 175:116797. https:\/\/doi.org\/10.1016\/j.biopha.2024.116797","journal-title":"Biomed Pharmacother"},{"key":"12004_CR19","doi-asserted-by":"publisher","unstructured":"Walke G, Gaurkar SS, Prasad R, Lohakare T, Wanjari M (2023) The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation. Cureus. 15(7):e42583 https:\/\/doi.org\/10.7759\/cureus.42583","DOI":"10.7759\/cureus.42583"},{"key":"12004_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s12011-019-01865-6","volume":"195","author":"AA Fouad","year":"2020","unstructured":"Fouad AA, Abdel-Aziz AM, Hamouda AAH (2020) Diacerein Downregulates NLRP3\/Caspase-1\/IL-1\u03b2 and IL-6\/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity, Biol. Trace Elem Res 195:499\u2013505. https:\/\/doi.org\/10.1007\/s12011-019-01865-6","journal-title":"Trace Elem Res"},{"key":"12004_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.lfs.2018.07.060","volume":"209","author":"SA Abdel-Gaber","year":"2018","unstructured":"Abdel-Gaber SA, Mohammed RK, Refaie MMM (2018) Mechanism mediating the protective effect of diacerein in ischemia-reperfusion-induced testicular injury in rats. Life Sci 209:57\u201362. https:\/\/doi.org\/10.1016\/j.lfs.2018.07.060","journal-title":"Life Sci"},{"key":"12004_CR22","doi-asserted-by":"publisher","first-page":"102767","DOI":"10.1016\/j.tice.2025.102767","volume":"93","author":"A Alayn\u2019Al-marddyah","year":"2025","unstructured":"Alayn\u2019Al-marddyah A, Abukhalil MH, Althunibat OY, Jaber FA, Alaryani FS, Saleh AM, Albalawi AE, Alhasani RH (2025) Taxifolin mitigates cisplatin-induced testicular damage by reducing inflammation, oxidative stress, and apoptosis in mice. Tissue Cell 93:102767","journal-title":"Tissue Cell"},{"key":"12004_CR23","doi-asserted-by":"publisher","first-page":"102144","DOI":"10.1016\/j.bbrep.2025.102144","volume":"43","author":"A RE","year":"2025","unstructured":"RE A, TM A, CA A (2025) Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB \/NO\/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats. Biochem Biophys Rep 43:102144. https:\/\/doi.org\/10.1016\/j.bbrep.2025.102144","journal-title":"Biochem Biophys Rep"},{"key":"12004_CR24","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/19396368.2018.1450460","volume":"64","author":"M Tian","year":"2018","unstructured":"Tian M, Liu F, Liu H, Zhang Q, Li L, Hou X, Zhao J, Li S, Chang X, Sun Y (2018) Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Reprod Med 64:246\u2013259","journal-title":"Syst Biol Reprod Med"},{"key":"12004_CR25","doi-asserted-by":"publisher","first-page":"14574","DOI":"10.3390\/ijms241914574","volume":"24","author":"JS Katani\u0107 Stankovi\u0107","year":"2023","unstructured":"Katani\u0107 Stankovi\u0107 JS, Selakovi\u0107 D, Rosi\u0107 G (2023) Oxidative damage as a fundament of systemic toxicities induced by cisplatin\u2014the crucial limitation or potential therapeutic target? Int J Mol Sci 24:14574","journal-title":"Int J Mol Sci"},{"key":"12004_CR26","doi-asserted-by":"publisher","first-page":"255","DOI":"10.5487\/TR.2017.33.3.255","volume":"33","author":"AR Fallahzadeh","year":"2017","unstructured":"Fallahzadeh AR, Rezaei Z, Rahimi HR, Barmak MJ, Sadeghi H, Mehrabi S, Rabani SM, Kashani IR, Barati V, Mahmoudi R (2017) Evaluation of the effect of pentoxifylline on cisplatin-induced testicular toxicity in rats. Toxicol Res 33:255\u2013263. https:\/\/doi.org\/10.5487\/TR.2017.33.3.255","journal-title":"Toxicol Res"},{"key":"12004_CR27","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1007\/s43032-024-01662-0","volume":"31","author":"DE Rotimi","year":"2024","unstructured":"Rotimi DE, Acho MA, Falana BM, Olaolu TD, Mgbojikwe I, Ojo OA, Adeyemi OS (2024) Oxidative stress-induced hormonal disruption in male reproduction. Reprod Sci 31:2943\u20132956","journal-title":"Reprod Sci"},{"key":"12004_CR28","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1007\/s11255-024-04338-5","volume":"57","author":"A Kokurcan","year":"2025","unstructured":"Kokurcan A, Sand\u0131k\u00e7\u0131 F, Y\u0131lmaz M\u015e, \u00d6zt\u00fcrk U, Do\u011fan K, Y\u0131lmazer D, Ayd\u0131n FN, Yal\u00e7\u0131nda\u011f A, \u0130mamo\u011flu A (2025) Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity. Int Urol Nephrol 57:1441\u20131449","journal-title":"Int Urol Nephrol"},{"key":"12004_CR29","doi-asserted-by":"publisher","first-page":"2378212","DOI":"10.1080\/0886022X.2024.2378212","volume":"46","author":"AE Altyar","year":"2024","unstructured":"Altyar AE, Albadrani GM, Farouk SM, Alamoudi MK, Sayed AA, Mohammedsaleh ZM, Al-Ghadi MQ, Saleem RM, Sakr HI, Abdel-Daim MM (2024) The antioxidant, anti-inflammatory, and anti-apoptotic effects of sesamin against cisplatin-induced renal and testicular toxicity in rats. Ren Fail 46:2378212","journal-title":"Ren Fail"},{"key":"12004_CR30","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00210-023-02696-y","volume":"397","author":"EE Besong","year":"2024","unstructured":"Besong EE, Ashonibare PJ, Akhigbe TM, Obimma JN, Akhigbe RE (2024) Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS\/NO\/cGMP signaling and activating Nrf2\/HO-1 in male Wistar rat, Naunyn. Schmiedebergs Arch Pharmacol 397:1233\u20131243","journal-title":"Schmiedebergs Arch Pharmacol"},{"key":"12004_CR31","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3390\/metabo12070648","volume":"12","author":"W Al-Amarat","year":"2022","unstructured":"Al-Amarat W, Abukhalil MH, Alruhaimi RS, Alqhtani HA, Aldawood N, Alfwuaires MA, Althunibat OY, Aladaileh SH, Algefare AI, Alanezi AA (2022) Upregulation of Nrf2\/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against cyclophosphamide hepatotoxicity. Metabolites 12:648","journal-title":"Metabolites"},{"key":"12004_CR32","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.3390\/cells11101690","volume":"11","author":"J Zhang","year":"2022","unstructured":"Zhang J, Fang Y, Tang D, Xu X, Zhu X, Wu S, Yu H, Cheng H, Luo T, Shen Q (2022) Activation of MT1\/MT2 to protect testes and leydig cells against cisplatin-induced oxidative stress through the SIRT1\/Nrf2 signaling pathway. Cells 11:1690","journal-title":"Cells"},{"key":"12004_CR33","doi-asserted-by":"publisher","unstructured":"Arafa EA, Hassanein EHM, Hussein RM, Mohamed WR (2025) Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2\/Keap1\/HO-1 and PPAR\u03b3 signaling. Naunyn Schmiedebergs Arch Pharmacol. 398(8):10509\u201310522. https:\/\/doi.org\/10.1007\/s00210-025-03924-3","DOI":"10.1007\/s00210-025-03924-3"},{"key":"12004_CR34","doi-asserted-by":"crossref","unstructured":"Fan S, Xiao X, Feng R, Sun S, You J, Yan X, Lv D, Liu M, Wang H, Wang W (2025) Echinacoside ameliorates cisplatin-induced acute kidney injury through activation of the NRF2\/HO-1 signaling pathway. Biochem Pharmacol 117411","DOI":"10.1016\/j.bcp.2025.117411"},{"key":"12004_CR35","doi-asserted-by":"publisher","first-page":"121441","DOI":"10.1016\/j.lfs.2023.121441","volume":"316","author":"AA Shaaban","year":"2023","unstructured":"Shaaban AA, Zaghloul RA, Kafl HE, El-Kashef DH (2023) Ameliorative effect of desloratadine against cisplatin-induced renal and testicular toxicity in rats: Attention to TLR4\/NLRP3 inflammasome signaling pathway. Life Sci 316:121441","journal-title":"Life Sci"},{"key":"12004_CR36","doi-asserted-by":"publisher","first-page":"e13786","DOI":"10.1111\/and.13786","volume":"52","author":"AC Famurewa","year":"2020","unstructured":"Famurewa AC, Ekeleme-Egedigwe CA, Onwe CS, Egedigwe UO, Okoro CO, Egedigwe UJ, Asogwa NT (2020) Ginger juice prevents cisplatin\u2010induced oxidative stress, endocrine imbalance and NO\/iNOS\/NF\u2010\u03baB signalling via modulating testicular redox\u2010inflammatory mechanism in rats. Andrologia 52:e13786","journal-title":"Andrologia"},{"key":"12004_CR37","doi-asserted-by":"publisher","first-page":"41948","DOI":"10.1007\/s11356-021-13544-y","volume":"28","author":"EHM Hassanein","year":"2021","unstructured":"Hassanein EHM, Abdel-Wahab BA, Ali FEM, Abd El-Ghafar OAM, Kozman MR, Sharkawi SMZ (2021) Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1\/2 signaling pathways. Environ Sci Pollut Res 28:41948\u201341964. https:\/\/doi.org\/10.1007\/s11356-021-13544-y","journal-title":"Environ Sci Pollut Res"},{"key":"12004_CR38","doi-asserted-by":"publisher","first-page":"122080","DOI":"10.1016\/j.lfs.2023.122080","volume":"331","author":"MM Samaha","year":"2023","unstructured":"Samaha MM, Nour OA, Sewilam HM, El-Kashef DH (2023) Diacerein mitigates adenine-induced chronic kidney disease in rats: Focus on TLR4\/MYD88\/TRAF6\/NF-\u03baB pathway. Life Sci 331:122080. https:\/\/doi.org\/10.1016\/j.lfs.2023.122080","journal-title":"Life Sci"},{"key":"12004_CR39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3390\/antiox11020246","volume":"11","author":"AK Aranda-Rivera","year":"2022","unstructured":"Aranda-Rivera AK, Srivastava A, Cruz-Gregorio A, Pedraza-Chaverri J, Mulay SR, Scholze A (2022) Involvement of inflammasome components in kidney disease. Antioxidants 11:246","journal-title":"Antioxidants"},{"key":"12004_CR40","doi-asserted-by":"publisher","unstructured":"Moustafa PE, Farouk H, Khattab MS, El\u2011Marasy SA (2025) Diacerein counteracts amiodarone\u2011induced hepatotoxicity in rats via targeting TLR4\/NF-kB\/NLRP3 pathways. Toxicology Mechanisms and Methods. 35(7):787\u201399. https:\/\/doi.org\/10.1080\/15376516.2025.2499024","DOI":"10.1080\/15376516.2025.2499024"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12004-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12004-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12004-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:26:48Z","timestamp":1779445608000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12004-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12004"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12004-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"27 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Gellan Alaa Mohamed Kamel: Conceptualization, Methodology, Software, Data curation, Validation, Investigation, Writing \u2013 original draft. Shaimaa Hussein: Visualization, Supervision, and Reviewing.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authorship contribution statement"}}],"article-number":"810"}}