{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:28Z","timestamp":1790185288999,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Suleyman Demirel University","award":["TSG-2024-9515"],"award-info":[{"award-number":["TSG-2024-9515"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12006-3","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:41:21Z","timestamp":1779799281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Theranekron attenuates lipopolysaccharide-induced neuroinflammation via NLRP3 inflammasome modulation"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-4062","authenticated-orcid":false,"given":"Ali Serdar","family":"Oguzoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-035X","authenticated-orcid":false,"given":"Halil","family":"Asci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-2096","authenticated-orcid":false,"given":"Sanem","family":"Asci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7279-0026","authenticated-orcid":false,"given":"Musa","family":"Canan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2845-3744","authenticated-orcid":false,"given":"Rumeysa","family":"Taner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1743-412X","authenticated-orcid":false,"given":"Abdurrahman","family":"Gulal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-5265","authenticated-orcid":false,"given":"Isa Gokhan","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-6089","authenticated-orcid":false,"given":"Mert","family":"Oktem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-3150","authenticated-orcid":false,"given":"Nilgun","family":"Senol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-1082","authenticated-orcid":false,"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"12006_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1750-1326-4-47","volume":"4","author":"TC Frank-Cannon","year":"2009","unstructured":"Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG (2009) Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4:47. https:\/\/doi.org\/10.1186\/1750-1326-4-47","journal-title":"Mol Neurodegener"},{"key":"12006_CR2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.2174\/1567202611666140520122744","volume":"11","author":"M Michels","year":"2014","unstructured":"Michels M, Danielski L, Dal-Pizzol F, Petronilho F (2014) Neuroinflammation: microglial activation during sepsis. Curr Neurovasc Res 11:262\u2013270. https:\/\/doi.org\/10.2174\/1567202611666140520122744","journal-title":"Curr Neurovasc Res"},{"key":"12006_CR3","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.it.2016.08.001","volume":"37","author":"M Schwartz","year":"2016","unstructured":"Schwartz M, Deczkowska A (2016) Neurological disease as a failure of brain\u2013immune crosstalk: the multiple faces of neuroinflammation. Trends Immunol 37:668\u2013679. https:\/\/doi.org\/10.1016\/j.it.2016.08.001","journal-title":"Trends Immunol"},{"key":"12006_CR4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/jnr.24184","volume":"96","author":"MY Hamasaki","year":"2018","unstructured":"Hamasaki MY, Machado MCC, Pinheiro da Silva F (2018) Animal models of neuroinflammation secondary to acute insults originated outside the brain. J Neurosci Res 96:371\u2013378. https:\/\/doi.org\/10.1002\/jnr.24184","journal-title":"J Neurosci Res"},{"key":"12006_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.153951","volume":"100","author":"JP O\u2019Callaghan","year":"2019","unstructured":"O\u2019Callaghan JP, Miller DB (2019) Neuroinflammation disorders exacerbated by environmental stressors. Metabolism 100:153951. https:\/\/doi.org\/10.1016\/j.metabol.2019.153951","journal-title":"Metabolism"},{"key":"12006_CR6","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1021\/acschemneuro.0c00427","volume":"11","author":"N Kaur","year":"2020","unstructured":"Kaur N, Chugh H, Sakharkar MK et al (2020) Neuroinflammation mechanisms and phytotherapeutic intervention: a systematic review. ACS Chem Neurosci 11:3707\u20133731. https:\/\/doi.org\/10.1021\/acschemneuro.0c00427","journal-title":"ACS Chem Neurosci"},{"key":"12006_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41423-019-0223-3","volume":"16","author":"HYF Yong","year":"2019","unstructured":"Yong HYF, Rawji KS, Ghorbani S et al (2019) The benefits of neuroinflammation for the repair of the injured central nervous system. Cell Mol Immunol 16:540\u2013546. https:\/\/doi.org\/10.1038\/s41423-019-0223-3","journal-title":"Cell Mol Immunol"},{"key":"12006_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/bpa.12483","volume":"27","author":"MT Heneka","year":"2017","unstructured":"Heneka MT (2017) Inflammasome activation and innate immunity in Alzheimer\u2019s disease. Brain Pathol 27:220\u2013222. https:\/\/doi.org\/10.1111\/bpa.12483","journal-title":"Brain Pathol"},{"key":"12006_CR9","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s11033-022-08192-5","volume":"50","author":"I Ilhan","year":"2023","unstructured":"Ilhan I, Asci H, Tepebasi MY et al (2023) Selenium exerts protective effects on inflammatory cardiovascular damage: molecular aspects via SIRT1\/p53 and Cyt-c\/Cas-3 pathways. Mol Biol Rep 50:1627\u20131637. https:\/\/doi.org\/10.1007\/s11033-022-08192-5","journal-title":"Mol Biol Rep"},{"key":"12006_CR10","doi-asserted-by":"publisher","first-page":"8753","DOI":"10.1007\/s11033-022-07722-5","volume":"49","author":"M Savran","year":"2022","unstructured":"Savran M, Asci H, Erzurumlu Y et al (2022) Theranekron: a novel anti-inflammatory candidate for acetic acid-induced colonic inflammation in rats. Mol Biol Rep 49:8753\u20138760. https:\/\/doi.org\/10.1007\/s11033-022-07722-5","journal-title":"Mol Biol Rep"},{"key":"12006_CR11","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.2174\/1871530319666190306095532","volume":"19","author":"O Ozmen","year":"2019","unstructured":"Ozmen O, Topsakal S (2019) Pregabalin ameliorates lipopolysaccharide-induced pancreatic inflammation in aged rats. Endocr Metab Immune Disord Drug Targets 19:1141\u20131147. https:\/\/doi.org\/10.2174\/1871530319666190306095532","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"1","key":"12006_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA (2009) Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 4(1):31\u201336. https:\/\/doi.org\/10.1038\/nprot.2008.214","journal-title":"Nat Protoc"},{"key":"12006_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277\u2013285. https:\/\/doi.org\/10.1016\/j.clinbiochem.2003.11.015","journal-title":"Clin Biochem"},{"key":"12006_CR14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","volume":"129","author":"S Amor","year":"2010","unstructured":"Amor S, Puentes F, Baker D, Van der Valk P (2010) Inflammation in neurodegenerative diseases. Immunology 129:154\u2013169. https:\/\/doi.org\/10.1111\/j.1365-2567.2009.03225.x","journal-title":"Immunology"},{"key":"12006_CR15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00221-020-05983-9","volume":"239","author":"M Cheng","year":"2021","unstructured":"Cheng M, Geng Y, Chen Y et al (2021) \u03b4-Opioid receptor activation ameliorates lipopolysaccharide-induced inflammation and apoptosis by inhibiting the MAPK\/caspase-3 pathway in BV2 microglial cells. Exp Brain Res 239:401\u2013412. https:\/\/doi.org\/10.1007\/s00221-020-05983-9","journal-title":"Exp Brain Res"},{"key":"12006_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20643-3","volume":"8","author":"E Furube","year":"2018","unstructured":"Furube E, Kawai S, Inagaki H et al (2018) Brain region-dependent heterogeneity and dose-dependent difference in transient microglia population increase during lipopolysaccharide-induced inflammation. Sci Rep 8:2203. https:\/\/doi.org\/10.1038\/s41598-018-20643-3","journal-title":"Sci Rep"},{"key":"12006_CR17","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","volume":"21","author":"S Hickman","year":"2018","unstructured":"Hickman S, Izzy S, Sen P et al (2018) Microglia in neurodegeneration. Nat Neurosci 21:1359\u20131369. https:\/\/doi.org\/10.1038\/s41593-018-0242-x","journal-title":"Nat Neurosci"},{"key":"12006_CR18","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3389\/fnmol.2018.00320","volume":"11","author":"BZ Shao","year":"2018","unstructured":"Shao BZ, Cao Q, Liu C (2018) Targeting NLRP3 inflammasome in the treatment of CNS diseases. Front Mol Neurosci 11:320. https:\/\/doi.org\/10.3389\/fnmol.2018.00320","journal-title":"Front Mol Neurosci"},{"key":"12006_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9238290","volume":"2016","author":"K Zhou","year":"2016","unstructured":"Zhou K, Shi L, Wang Y et al (2016) Recent advances of the NLRP3 inflammasome in central nervous system disorders. J Immunol Res 2016:9238290. https:\/\/doi.org\/10.1155\/2016\/9238290","journal-title":"J Immunol Res"},{"key":"12006_CR20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1159\/000509798","volume":"83","author":"S Lin","year":"2020","unstructured":"Lin S, Mei X (2020) Role of NLRP3 inflammasomes in neuroinflammation diseases. Eur Neurol 83:576\u2013580. https:\/\/doi.org\/10.1159\/000509798","journal-title":"Eur Neurol"},{"key":"12006_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.coi.2020.10.011","volume":"68","author":"MT Milner","year":"2021","unstructured":"Milner MT, Maddugoda M, G\u00f6tz J et al (2021) The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer\u2019s disease. Curr Opin Immunol 68:116\u2013124. https:\/\/doi.org\/10.1016\/j.coi.2020.10.011","journal-title":"Curr Opin Immunol"},{"key":"12006_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2174\/1871524922666220929153215","volume":"22","author":"M Marino","year":"2022","unstructured":"Marino M, Mele E, Pastorino GMG et al (2022) Neuroinflammation: molecular mechanisms and therapeutic perspectives. Cent Nerv Syst Agents Med Chem 22:160\u2013174. https:\/\/doi.org\/10.2174\/1871524922666220929153215","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"12006_CR23","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1080\/14728222.2018.1515917","volume":"22","author":"N Gupta","year":"2018","unstructured":"Gupta N, Shyamasundar S, Patnala R et al (2018) Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies. Expert Opin Ther Targets 22:765\u2013771. https:\/\/doi.org\/10.1080\/14728222.2018.1515917","journal-title":"Expert Opin Ther Targets"},{"key":"12006_CR24","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/glia.22350","volume":"61","author":"C Cunningham","year":"2013","unstructured":"Cunningham C (2013) Microglia and neurodegeneration: the role of systemic inflammation. Glia 61:71\u201390. https:\/\/doi.org\/10.1002\/glia.22350","journal-title":"Glia"},{"key":"12006_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","volume":"6","author":"VH Perry","year":"2010","unstructured":"Perry VH, Nicoll JAR, Holmes C (2010) Microglia in neurodegenerative disease. Nat Rev Neurol 6:193\u2013201. https:\/\/doi.org\/10.1038\/nrneurol.2010.17","journal-title":"Nat Rev Neurol"},{"key":"12006_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/B978-0-12-815950-7.00004-7","volume-title":"Genetics, Neurology, Behavior, and Diet in Parkinson\u2019s Disease: The Neuroscience of Parkinson\u2019s Disease, Volume 2","author":"G Alam","year":"2020","unstructured":"Alam G, Richardson JR (2020) Regulation of tyrosine hydroxylase: relevance to Parkinson\u2019s disease. Genetics, Neurology, Behavior, and Diet in Parkinson\u2019s Disease: The Neuroscience of Parkinson\u2019s Disease, Volume 2. Elsevier, Amsterdam, pp 51\u201366. https:\/\/doi.org\/10.1016\/B978-0-12-815950-7.00004-7"},{"key":"12006_CR27","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00702-014-1238-7","volume":"121","author":"I Tekin","year":"2014","unstructured":"Tekin I, Roskoski R, Carkaci-Salli N, Vrana KE (2014) Complex molecular regulation of tyrosine hydroxylase. J Neural Transm 121:1451\u20131481. https:\/\/doi.org\/10.1007\/s00702-014-1238-7","journal-title":"J Neural Transm"},{"key":"12006_CR28","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2174\/187152712800792785","volume":"11","author":"S Tabrez","year":"2012","unstructured":"Tabrez S, Jabir NR, Shakil S et al (2012) A synopsis on the role of tyrosine hydroxylase in Parkinson\u2019s disease. CNS Neurol Disord Drug Targets 11:395\u2013409. https:\/\/doi.org\/10.2174\/187152712800792785","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"12006_CR29","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1161\/HYPERTENSIONAHA.121.17517","volume":"78","author":"L Ca\u00f1es","year":"2021","unstructured":"Ca\u00f1es L, Alonso J, Ballester-Servera C et al (2021) Targeting tyrosine hydroxylase for abdominal aortic aneurysm: impact on inflammation, oxidative stress, and vascular remodeling. Hypertension 78:681\u2013692. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.17517","journal-title":"Hypertension"},{"key":"12006_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1515\/pterid-2013-0001","volume":"24","author":"S Geisler","year":"2013","unstructured":"Geisler S, Gostner JM, Becker K et al (2013) Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio. Pteridines 24:27\u201331. https:\/\/doi.org\/10.1515\/pterid-2013-0001","journal-title":"Pteridines"},{"key":"12006_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00315","volume":"8","author":"G Singhal","year":"2014","unstructured":"Singhal G, Jaehne EJ, Corrigan F et al (2014) Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci 8:315. https:\/\/doi.org\/10.3389\/fnins.2014.00315","journal-title":"Front Neurosci"},{"key":"12006_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153238","volume":"75","author":"M Olcum","year":"2020","unstructured":"Olcum M, Tastan B, Ercan I et al (2020) Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: a review. Phytomedicine 75:153238. https:\/\/doi.org\/10.1016\/j.phymed.2020.153238","journal-title":"Phytomedicine"},{"key":"12006_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00216","volume":"8","author":"S Alfonso-Loeches","year":"2014","unstructured":"Alfonso-Loeches S, Ure\u00f1a-Peralta JR, Morillo-Bargues MJ et al (2014) Role of mitochondrial ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front Cell Neurosci 8:216. https:\/\/doi.org\/10.3389\/fncel.2014.00216","journal-title":"Front Cell Neurosci"},{"key":"12006_CR34","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/JIR.S141220","volume":"11","author":"M Groslambert","year":"2018","unstructured":"Groslambert M, Py B (2018) Spotlight on the NLRP3 inflammasome pathway. J Inflamm Res 11:359\u2013374. https:\/\/doi.org\/10.2147\/JIR.S141220","journal-title":"J Inflamm Res"},{"key":"12006_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175481","volume":"27","author":"A Skrzypczak-Wiercioch","year":"2022","unstructured":"Skrzypczak-Wiercioch A, Sa\u0142at K (2022) Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use. Molecules 27:5481. https:\/\/doi.org\/10.3390\/molecules27175481","journal-title":"Molecules"},{"key":"12006_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-34650-8","volume":"16","author":"SM Baraka","year":"2026","unstructured":"Baraka SM, Hussien YA, Ahmed-Farid OA et al (2026) Neuroprotective potential of eugenol against acrylamide-induced brain toxicity by regulating Nrf2\/NQO1\/HO-1 and NLRP3\/NF-\u03baB\/IL-1\u03b2 signaling cascades. Sci Rep 16:3265. https:\/\/doi.org\/10.1038\/s41598-025-34650-8","journal-title":"Sci Rep"},{"key":"12006_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-024-01513-6","volume":"40","author":"DAH Deabes","year":"2025","unstructured":"Deabes DAH, El-Abd EAW, Baraka SM et al (2025) Metabolomics analyses and comparative insight to neuroprotective potential of unripe fruits and leaves of Citrus aurantium ethanolic extracts against cadmium-induced rat brain dysfunction: involvement of oxidative stress and akt-mediated CREB\/BDNF and GSK3\u03b2\/NF-\u03baB signaling pathways. Metab Brain Dis 40:89. https:\/\/doi.org\/10.1007\/s11011-024-01513-6","journal-title":"Metab Brain Dis"},{"key":"12006_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104444","volume":"105","author":"SM Baraka","year":"2020","unstructured":"Baraka SM, Saleh DO, Ghaly NS et al (2020) Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: the interplay of NF-\u03baB\/IL-6 and Nrf2\/HO-1 signaling pathways. Bioorg Chem 105:104444. https:\/\/doi.org\/10.1016\/j.bioorg.2020.104444","journal-title":"Bioorg Chem"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12006-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12006-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12006-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:41:22Z","timestamp":1779799282000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12006-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12006"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12006-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"21 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental procedures were approved by the Animal Experiments Local Ethics Committee of Suleyman Demirel University (Approval No: 06.06.2024\u201307\/303) and conducted in accordance with the ARRIVE 2.0 guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"829"}}