{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:04:36Z","timestamp":1784700276377,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4-4\/165M\/2020-NCD-II"],"award-info":[{"award-number":["5\/4-4\/165M\/2020-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4-4\/165M\/2020-NCD-II"],"award-info":[{"award-number":["5\/4-4\/165M\/2020-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ganapati Sugar Industries Ltd","award":["CSR-Funds 2021-2022"],"award-info":[{"award-number":["CSR-Funds 2021-2022"]}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research, India","doi-asserted-by":"crossref","award":["5\/4-4\/165M\/2020-NCD-II"],"award-info":[{"award-number":["5\/4-4\/165M\/2020-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12018-z","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:13:10Z","timestamp":1780571590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of GABAA receptors and chloride transporters in autism \u2013 An explorative analysis using peripheral blood as a model"],"prefix":"10.1007","volume":"53","author":[{"given":"Pallabi","family":"Adak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samidh Sankar","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurba Kumar","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagata","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjana","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"12018_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (DSMV), Fifth Edition, Washington, DC, USA","DOI":"10.1176\/appi.books.9780890425596"},{"key":"12018_CR2","unstructured":"Centers for Disease Control and Prevention Prevalence of Autism Spectrum Disorder among Children Aged 8 Years\u2014Autism and Developmental Disabilities Monitoring Network, 11Sites, USA;2018"},{"key":"12018_CR3","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1002\/aur.1812","volume":"10","author":"A Rudra","year":"2017","unstructured":"Rudra A, Belmonte MK, Soni PK, Banerjee S, Mukerji S, Chakrabarti B (2017) Prevalence of autism spectrum disorder and autistic symptoms in a school-based cohort of children in Kolkata, India. Autism research: official J Int Soc Autism Res 10:1597\u20131605. https:\/\/doi.org\/10.1002\/aur.1812","journal-title":"Autism research: official J Int Soc Autism Res"},{"key":"12018_CR4","doi-asserted-by":"publisher","first-page":"781327","DOI":"10.3389\/fcell.2021.781327","volume":"9","author":"H Zhao","year":"2022","unstructured":"Zhao H, Mao X, Zhu C, Zou X, Peng F, Yang W, Li B, Li G, Ge T, Cui R (2022) GABAergic System Dysfunction in Autism Spectrum Disorders. Front Cell Dev Biol 9:781327. https:\/\/doi.org\/10.3389\/fcell.2021.781327","journal-title":"Front Cell Dev Biol"},{"key":"12018_CR5","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41398-018-0155-1","volume":"8","author":"J Horder","year":"2018","unstructured":"Horder J, Petrinovic MM, Mendez MA, Bruns A, Takumi T, Spooren W, Barker GJ, K\u00fcnnecke B, Murphy DG (2018) Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models. Transl Psychiatry 8:106. https:\/\/doi.org\/10.1038\/s41398-018-0155-1","journal-title":"Transl Psychiatry"},{"key":"12018_CR6","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.neubiorev.2012.07.005","volume":"36","author":"S Coghlan","year":"2012","unstructured":"Coghlan S, Horder J, Inkster B, Mendez MA, Murphy DG, Nutt DJ (2012) GABA system dysfunction in autism and related disorders: from synapse to symptoms. Neurosci Biobehav Rev reviews 36:2044\u20132055. https:\/\/doi.org\/10.1016\/j.neubiorev.2012.07.005","journal-title":"Neurosci Biobehav Rev reviews"},{"key":"12018_CR7","doi-asserted-by":"publisher","unstructured":"Rubenstein JL, Merzenich MM (2003) Model of autism: increased ratio of excitation\/inhibition in key neural systems. Genes Brain Behav. 2003;2: 255\u2013267. https:\/\/doi.org\/10.1034\/j.1601-183x.2003.00037.x","DOI":"10.1034\/j.1601-183x.2003.00037.x"},{"key":"12018_CR8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature10360","volume":"477","author":"O Yizhar","year":"2011","unstructured":"Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O\u2019Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011) Neocortical excitation\/inhibition balance in information processing and social dysfunction. Nature 477:171\u2013178. https:\/\/doi.org\/10.1038\/nature10360","journal-title":"Nature"},{"key":"12018_CR9","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1007\/s00018-021-03846-2","volume":"78","author":"E Sallard","year":"2021","unstructured":"Sallard E, Letourneur D, Legendre P (2021) Electrophysiology of ionotropic GABA receptors. Cell Mol Life Sci 78:5341\u20135370. https:\/\/doi.org\/10.1007\/s00018-021-03846-2","journal-title":"Cell Mol Life Sci"},{"key":"12018_CR10","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.neuron.2011.05.002","volume":"70","author":"SJ Sanders","year":"2011","unstructured":"Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu S, H, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM et al (2011) Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 70:863\u2013885. https:\/\/doi.org\/10.1016\/j.neuron.2011.05.002","journal-title":"Neuron"},{"key":"12018_CR11","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1086\/367846","volume":"72","author":"Y Shao","year":"2003","unstructured":"Shao Y, Cuccaro ML, Hauser ER, Raiford KL, Menold MM, Wolpert CM, Ravan SA, Elston L, Decena K, Donnelly SL, Abramson RK, Wright HH, DeLong GR, Gilbert JR, Pericak-Vance MA (2003) Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. Am J Hum Genet 72:539\u2013548. https:\/\/doi.org\/10.1086\/367846","journal-title":"Am J Hum Genet"},{"key":"12018_CR12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1086\/433195","volume":"77","author":"DQ Ma","year":"2005","unstructured":"Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA (2005) Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet 77:377\u2013388. https:\/\/doi.org\/10.1086\/433195","journal-title":"Am J Hum Genet"},{"key":"12018_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/2040-2392-5-36","volume":"5","author":"CH Chen","year":"2014","unstructured":"Chen CH, Huang CC, Cheng MC, Chiu YN, Tsai WC, Wu YY, Liu SK, Gau SS (2014) Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders. Mol Autism 5:36. https:\/\/doi.org\/10.1186\/2040-2392-5-36","journal-title":"Mol Autism"},{"key":"12018_CR14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.neubiorev.2018.05.001","volume":"90","author":"JT Schulte","year":"2018","unstructured":"Schulte JT, Wierenga CJ, Bruining H (2018) Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions. Neurosci Biobehav Rev 90:260\u2013271. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.05.001","journal-title":"Neurosci Biobehav Rev"},{"key":"12018_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1113\/jphysiol.2004.077495","volume":"562","author":"C Rivera","year":"2005","unstructured":"Rivera C, Voipio J, Kaila K (2005) Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol 562:27\u201336. https:\/\/doi.org\/10.1113\/jphysiol.2004.077495","journal-title":"J Physiol"},{"key":"12018_CR16","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tins.2017.07.001","volume":"40","author":"Y Ben-Ari","year":"2017","unstructured":"Ben-Ari Y (2017) NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders. Trends Neurosci 40:536\u2013554. https:\/\/doi.org\/10.1016\/j.tins.2017.07.001","journal-title":"Trends Neurosci"},{"key":"12018_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1177\/1073858412438697","volume":"18","author":"Y Ben-Ari","year":"2012","unstructured":"Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E (2012) The GABA excitatory\/inhibitory shift in brain maturation and neurological disorders. The Neuroscientist: a review journal bringing neurobiology. Neurol psychiatry 18:467\u2013486. https:\/\/doi.org\/10.1177\/1073858412438697","journal-title":"Neurol psychiatry"},{"key":"12018_CR18","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fncel.2015.00386","volume":"9","author":"ND Merner","year":"2015","unstructured":"Merner ND, Chandler MR, Bourassa C, Liang B, Khanna AR, Dion P, Rouleau GA, Kahle KT (2015) Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Front cell neurosci 9:386. https:\/\/doi.org\/10.3389\/fncel.2015.00386","journal-title":"Front cell neurosci"},{"key":"12018_CR19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/apha.12440","volume":"213","author":"AK Bhandage","year":"2015","unstructured":"Bhandage AK, Hellgren C, Jin Z, Olafsson EB, Sundstr\u00f6m-Poromaa I, Birnir B (2015) Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health. Acta Physiol (Oxford England) 213:575\u2013585. https:\/\/doi.org\/10.1111\/apha.12440","journal-title":"Acta Physiol (Oxford England)"},{"key":"12018_CR20","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.molimm.2005.07.025","volume":"43","author":"S Alam","year":"2006","unstructured":"Alam S, Laughton DL, Walding A, Wolstenholme AJ (2006) Human peripheral blood mononuclear cells express GABAA receptor subunits. Mol Immunol 43:1432\u20131442. https:\/\/doi.org\/10.1016\/j.molimm.2005.07.025","journal-title":"Mol Immunol"},{"key":"12018_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3390\/biology13060377","volume":"13","author":"S Cho","year":"2024","unstructured":"Cho S, Soumare F, Mumford SL, Rosas PC, Abrieva Z, Davis JM, Hamidovic A (2024) Peripheral Blood Mononuclear Cell Expression of Cation-Chloride Cotransporter (CCC) Genes in Premenstrual Dysphoric Disorder (PMDD) across the Menstrual Cycle-A Preliminary Study. Biology 13:377. https:\/\/doi.org\/10.3390\/biology13060377","journal-title":"Biology"},{"key":"12018_CR22","unstructured":"Schopler E, Reichler RJ, Renner BR (1988) The childhood autism rating scale. Western Psychological Services"},{"key":"12018_CR23","unstructured":"Helsinki. World Medical Association. Ethical principles for medical research involving human subjects. 52nd WMA General Assembly (2002) ; http:\/\/www.wma.net"},{"key":"12018_CR24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10522-015-9561-4","volume":"16","author":"D Capeleto","year":"2015","unstructured":"Capeleto D, Barbisan F, Azzolin V, Dornelles EB, Rogalski F, Teixeira CF, Machado A, K, Cadon\u00e1 FC, da Silva T, Duarte T, Duarte MM, da Cruz IB (2015) The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism. Biogerontology 16:621\u2013630. https:\/\/doi.org\/10.1007\/s10522-015-9561-4","journal-title":"Biogerontology"},{"key":"12018_CR25","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3390\/ph14100967","volume":"14","author":"S Guzel","year":"2021","unstructured":"Guzel S, Cai CL, Aranda JV, Beharry KD (2021) Dose Response of Bumetanide on Aquaporins and Angiogenesis Biomarkers in Human Retinal Endothelial Cells Exposed to Intermittent Hypoxia. Pharmaceuticals (Basel Switzerland) 14:967. https:\/\/doi.org\/10.3390\/ph14100967","journal-title":"Pharmaceuticals (Basel Switzerland)"},{"key":"12018_CR26","doi-asserted-by":"publisher","unstructured":"Kumar P, Nagarajan A, Uchil P (2018) Analysis of Cell Viability by the MTT Assay. Cold Spring Harbor Protoc 2018. https:\/\/doi.org\/10.1101\/pdb.prot095505. https:\/\/doi.org\/10.1101\/pdb.prot095505","DOI":"10.1101\/pdb.prot095505"},{"key":"12018_CR27","doi-asserted-by":"publisher","first-page":"eaau0164","DOI":"10.1126\/scitranslmed.aau0164","volume":"11","author":"X Tang","year":"2019","unstructured":"Tang X, Drotar J, Li K, Clairmont CD, Brumm AS, Sullins AJ, Wu H, Liu XS, Wang J, Gray NS, Sur M, Jaenisch R (2019) Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice. Sci Transl Med 11:eaau0164. https:\/\/doi.org\/10.1126\/scitranslmed.aau0164","journal-title":"Sci Transl Med"},{"key":"12018_CR28","doi-asserted-by":"publisher","first-page":"14277","DOI":"10.1038\/s41598-022-18628-4","volume":"12","author":"N Banerjee","year":"2022","unstructured":"Banerjee N, Adak P (2022) Birth related parameters are important contributors in autism spectrum disorders. Sci Rep 12:14277. https:\/\/doi.org\/10.1038\/s41598-022-18628-4","journal-title":"Sci Rep"},{"key":"12018_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fped.2014.00070","volume":"2","author":"G Cellot","year":"2014","unstructured":"Cellot G, Cherubini E (2014) GABAergic signaling as therapeutic target for autism spectrum disorders. Front pediatr 2:70. https:\/\/doi.org\/10.3389\/fped.2014.00070","journal-title":"Front pediatr"},{"key":"12018_CR30","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/s0896-6273(02)01053-x","volume":"36","author":"M Demarque","year":"2002","unstructured":"Demarque M, Represa A, Becq H, Khalilov I, Ben-Ari Y, Aniksztejn L (2002) Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation. Neuron 36:1051\u20131061. https:\/\/doi.org\/10.1016\/s0896-6273(02)01053-x","journal-title":"Neuron"},{"key":"12018_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s004410000343","volume":"305","author":"L Nguyen","year":"2001","unstructured":"Nguyen L, Rigo JM, Rocher V, Belachew S, Malgrange B, Rogister B, Leprince P, Moonen G (2001) Neurotransmitters as early signals for central nervous system development. Cell Tissue Res 305:187\u2013202. https:\/\/doi.org\/10.1007\/s004410000343","journal-title":"Cell Tissue Res"},{"key":"12018_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00726-011-1193-7","volume":"45","author":"Z Jin","year":"2013","unstructured":"Jin Z, Mendu SK, Birnir B (2013) GABA Is an Effective Immunomodulatory Molecule. Amino Acids 45:87\u201394. https:\/\/doi.org\/10.1007\/s00726-011-1193-7","journal-title":"Amino Acids"},{"key":"12018_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11011-026-01791-2","volume":"41","author":"A El-Ansary","year":"2026","unstructured":"El-Ansary A, Al-Ayadhi LY, Alfawaz HA, Al-Ghabban H, Bj\u00f8rklund G (2026) Plasma KCC2, NKCC1, and GABA as peripheral biomarkers in autism spectrum disorder: a combined ROC analysis. Metab Brain Dis 41:29. https:\/\/doi.org\/10.1007\/s11011-026-01791-2","journal-title":"Metab Brain Dis"},{"key":"12018_CR34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/antiox9030188","volume":"9","author":"M Malaguarnera","year":"2020","unstructured":"Malaguarnera M, Khan H, Cauli O (2020) Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects. Antioxid (Basel Switzerland) 9:188. https:\/\/doi.org\/10.3390\/antiox9030188","journal-title":"Antioxid (Basel Switzerland)"},{"key":"12018_CR35","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/cells9010240","volume":"9","author":"BL Tang","year":"2020","unstructured":"Tang BL (2020) The Expanding Therapeutic Potential of Neuronal KCC2. Cells 9:240. https:\/\/doi.org\/10.3390\/cells9010240","journal-title":"Cells"},{"key":"12018_CR36","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1231097","volume":"339","author":"BP Hubbard","year":"2013","unstructured":"Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA (2013) Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Sci (New York N Y) 339:1216\u20131219. https:\/\/doi.org\/10.1126\/science.1231097","journal-title":"Sci (New York N Y)"},{"key":"12018_CR37","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1038\/tp.2012.124","volume":"2","author":"E Lemonnier","year":"2012","unstructured":"Lemonnier E, Degrez C, Phelep M, Tyzio R, Josse F, Grandgeorge M, Hadjikhani N, Ben-Ari Y (2012) A randomised controlled trial of bumetanide in the treatment of autism in children. Transl Psychiatry 2:e202. https:\/\/doi.org\/10.1038\/tp.2012.124","journal-title":"Transl Psychiatry"},{"key":"12018_CR38","doi-asserted-by":"publisher","first-page":"751575","DOI":"10.3389\/fpsyt.2021.751575","volume":"12","author":"T Wang","year":"2021","unstructured":"Wang T, Shan L, Miao C, Xu Z, Jia F (2021) Treatment Effect of Bumetanide in Children With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Front Psychiatry 12:751575. https:\/\/doi.org\/10.3389\/fpsyt.2021.751575","journal-title":"Front Psychiatry"}],"updated-by":[{"DOI":"10.1007\/s11033-026-12271-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000}}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12018-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12018-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12018-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:34:28Z","timestamp":1784698468000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12018-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12018"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12018-z","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"8 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: Figures 1, 4, and 6 captions have been corrected, and Figures 2, 3, and 6 have been updated. Additionally, under the Results section in the subsection \u2018Details of the study participant\u2019, the term \u2018SIRT1 expression\u2019 has been revised to \u2018SIRT1 gene expression\u2019","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11033-026-12271-2","URL":"https:\/\/doi.org\/10.1007\/s11033-026-12271-2","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no potential conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Ethics Committee (PR-001-20).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the parents\/caregivers prior to the recruitment of the study participants.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"890"}}