{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:19:08Z","timestamp":1793837948864,"version":"4.6.1"},"reference-count":150,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12021-4","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:51:48Z","timestamp":1779803508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["FOXO transcription factors in Alzheimer\u2019s Disease: balancing neuroprotection and neuronal degeneration"],"prefix":"10.1007","volume":"53","author":[{"given":"Mukul","family":"Shyam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleen","family":"Veronica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oveyaa","family":"B M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathap","family":"Srirangan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendran","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Evan Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"12021_CR1","doi-asserted-by":"publisher","first-page":"e0338018","DOI":"10.1371\/journal.pone.0338018","volume":"20","author":"R Qin","year":"2025","unstructured":"Qin R, Zhao H, Gao H, Liu H (2025) Global trends in Alzheimer\u2019s disease and other dementias: A comprehensive analysis of incidence, socio-demographic variations, and future projections. PLoS ONE 20:e0338018. https:\/\/doi.org\/10.1371\/journal.pone.0338018","journal-title":"PLoS ONE"},{"key":"12021_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","volume":"71","author":"GS Bloom","year":"2014","unstructured":"Bloom GS (2014) Amyloid-\u03b2 and Tau. JAMA Neurol 71:505. https:\/\/doi.org\/10.1001\/jamaneurol.2013.5847","journal-title":"JAMA Neurol"},{"key":"12021_CR3","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/alz.12131","volume":"16","author":"M Mil\u00e0-Alom\u00e0","year":"2020","unstructured":"Mil\u00e0-Alom\u00e0 M, Salvad\u00f3 G, Gispert JD, Vilor\u2010Tejedor N, Grau\u2010Rivera O, Sala\u2010Vila A et al (2020) Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer\u2019s continuum. Alzheimer\u2019s Dement 16:1358\u20131371. https:\/\/doi.org\/10.1002\/alz.12131","journal-title":"Alzheimer\u2019s Dement"},{"key":"12021_CR4","doi-asserted-by":"publisher","unstructured":"Bennett KR, Surles-Zeigler MC, Augello CJ, Ako E, Rodgers VGJ, Ford BD Upregulation of CREB1 and FOXO1 transcription factor pathways in Neuregulin-1 mediated neuroprotection following ischemic stroke 2021. https:\/\/doi.org\/10.1101\/2021.11.17.468955","DOI":"10.1101\/2021.11.17.468955"},{"key":"12021_CR5","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/nen.0b013e318156a3d7","volume":"66","author":"CT Chu","year":"2007","unstructured":"Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL, Location, Location (2007) Location J Neuropathol Exp Neurol 66:873\u2013883. https:\/\/doi.org\/10.1097\/nen.0b013e318156a3d7","journal-title":"Location J Neuropathol Exp Neurol"},{"key":"12021_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1471-2202-5-48","volume":"5","author":"C Barth\u00e9l\u00e9my","year":"2004","unstructured":"Barth\u00e9l\u00e9my C, Henderson CE, Pettmann B (2004) Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci 5:48. https:\/\/doi.org\/10.1186\/1471-2202-5-48","journal-title":"BMC Neurosci"},{"key":"12021_CR7","doi-asserted-by":"publisher","unstructured":"Santos BF, Grenho I, Martel PJ, Ferreira BI, Link W FOXO family isoforms. Cell Death Dis 2023;14. https:\/\/doi.org\/10.1038\/s41419-023-06177-1","DOI":"10.1038\/s41419-023-06177-1"},{"key":"12021_CR8","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1093\/hmg\/ddt530","volume":"23","author":"E Pino","year":"2014","unstructured":"Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria J-C, Knott GW et al (2014) FOXO3 determines the accumulation of \u03b1-synuclein and controls the fate of dopaminergic neurons in the substantia nigra. Hum Mol Genet 23:1435\u20131452. https:\/\/doi.org\/10.1093\/hmg\/ddt530","journal-title":"Hum Mol Genet"},{"key":"12021_CR9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1196\/annals.1427.024","volume":"1147","author":"W Qin","year":"2008","unstructured":"Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S et al (2008) Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer\u2019s Disease\u2010type Amyloid Neuropathology and Spatial Memory Deterioration. Ann N Y Acad Sci 1147:335\u2013347. https:\/\/doi.org\/10.1196\/annals.1427.024","journal-title":"Ann N Y Acad Sci"},{"key":"12021_CR10","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.1093\/nar\/gkm703","volume":"35","author":"K-L Tsai","year":"2007","unstructured":"Tsai K-L, Sun Y-J, Huang C-Y, Yang J-Y, Hung M-C, Hsiao C-D (2007) Crystal structure of the human FOXO3a-DBD\/DNA complex suggests the effects of post-translational modification. Nucleic Acids Res 35:6984\u20136994. https:\/\/doi.org\/10.1093\/nar\/gkm703","journal-title":"Nucleic Acids Res"},{"key":"12021_CR11","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.str.2008.06.013","volume":"16","author":"MM Brent","year":"2008","unstructured":"Brent MM, Anand R, Marmorstein R (2008) Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification. Structure 16:1407\u20131416. https:\/\/doi.org\/10.1016\/j.str.2008.06.013","journal-title":"Structure"},{"key":"12021_CR12","doi-asserted-by":"publisher","first-page":"13106","DOI":"10.1074\/jbc.RA119.008649","volume":"294","author":"M Saline","year":"2019","unstructured":"Saline M, Badertscher L, Wolter M, Lau R, Gunnarsson A, Jacso T et al (2019) AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J Biol Chem 294:13106\u201313116. https:\/\/doi.org\/10.1074\/jbc.RA119.008649","journal-title":"J Biol Chem"},{"key":"12021_CR13","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1101\/gad.208926.112","volume":"26","author":"DAM Salih","year":"2012","unstructured":"Salih DAM, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA et al (2012) FoxO6 regulates memory consolidation and synaptic function. Genes Dev 26:2780\u20132801. https:\/\/doi.org\/10.1101\/gad.208926.112","journal-title":"Genes Dev"},{"key":"12021_CR14","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1053\/j.gastro.2009.06.049","volume":"137","author":"W Zhou","year":"2009","unstructured":"Zhou W, Cao Q, Peng Y, Zhang Q, Castrillon DH, DePinho RA et al (2009) FoxO4 Inhibits NF-\u03baB and Protects Mice Against Colonic Injury and Inflammation. Gastroenterology 137:1403\u20131414. https:\/\/doi.org\/10.1053\/j.gastro.2009.06.049","journal-title":"Gastroenterology"},{"key":"12021_CR15","doi-asserted-by":"publisher","unstructured":"Brown AK, Webb AE (2018) Regulation of FOXO Factors in Mammalian Cells, pp. 165\u201392. https:\/\/doi.org\/10.1016\/bs.ctdb.2017.10.006","DOI":"10.1016\/bs.ctdb.2017.10.006"},{"key":"12021_CR16","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1038\/sj.emboj.7600476","volume":"23","author":"MA Essers","year":"2004","unstructured":"Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL et al (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23:4802\u20134812. https:\/\/doi.org\/10.1038\/sj.emboj.7600476","journal-title":"EMBO J"},{"key":"12021_CR17","doi-asserted-by":"publisher","first-page":"R113","DOI":"10.1016\/j.cub.2007.01.008","volume":"17","author":"ME Carter","year":"2007","unstructured":"Carter ME, Brunet A (2007) FOXO transcription factors. Curr Biol 17:R113\u2013R114. https:\/\/doi.org\/10.1016\/j.cub.2007.01.008","journal-title":"Curr Biol"},{"key":"12021_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ceb.2008.02.005","volume":"20","author":"DA Salih","year":"2008","unstructured":"Salih DA, Brunet A (2008) FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20:126\u2013136. https:\/\/doi.org\/10.1016\/j.ceb.2008.02.005","journal-title":"Curr Opin Cell Biol"},{"key":"12021_CR19","doi-asserted-by":"publisher","first-page":"26729","DOI":"10.1074\/jbc.C200256200","volume":"277","author":"Y Furukawa-Hibi","year":"2002","unstructured":"Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N (2002) FOXO Forkhead Transcription Factors Induce G2-M Checkpoint in Response to Oxidative Stress. J Biol Chem 277:26729\u201326732. https:\/\/doi.org\/10.1074\/jbc.C200256200","journal-title":"J Biol Chem"},{"key":"12021_CR20","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.2337\/db11-0548","volume":"60","author":"DH Kim","year":"2011","unstructured":"Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE et al (2011) FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver. Diabetes 60:2763\u20132774. https:\/\/doi.org\/10.2337\/db11-0548","journal-title":"Diabetes"},{"key":"12021_CR21","doi-asserted-by":"publisher","unstructured":"Vidovi\u0107 T, Ewald CY Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease. Front Aging 2022;3. https:\/\/doi.org\/10.3389\/fragi.2022.935220","DOI":"10.3389\/fragi.2022.935220"},{"key":"12021_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","volume":"5","author":"J Paik","year":"2009","unstructured":"Paik J, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS et al (2009) FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis. Cell Stem Cell 5:540\u2013553. https:\/\/doi.org\/10.1016\/j.stem.2009.09.013","journal-title":"Cell Stem Cell"},{"key":"12021_CR23","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.tips.2022.09.010","volume":"43","author":"A Orea-Soufi","year":"2022","unstructured":"Orea-Soufi A, Paik J, Bragan\u00e7a J, Donlon TA, Willcox BJ, Link W (2022) FOXO transcription factors as therapeutic targets in human diseases. Trends Pharmacol Sci 43:1070\u20131084. https:\/\/doi.org\/10.1016\/j.tips.2022.09.010","journal-title":"Trends Pharmacol Sci"},{"key":"12021_CR24","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1038\/cdd.2015.123","volume":"22","author":"D-Y Kim","year":"2015","unstructured":"Kim D-Y, Hwang I, Muller FL, Paik J-H (2015) Functional regulation of FoxO1 in neural stem cell differentiation. Cell Death Differ 22:2034\u20132045. https:\/\/doi.org\/10.1038\/cdd.2015.123","journal-title":"Cell Death Differ"},{"key":"12021_CR25","doi-asserted-by":"publisher","first-page":"e1008097","DOI":"10.1371\/journal.pgen.1008097","volume":"15","author":"AJ Audesse","year":"2019","unstructured":"Audesse AJ, Dhakal S, Hassell L-A, Gardell Z, Nemtsova Y, Webb AE (2019) FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet 15:e1008097. https:\/\/doi.org\/10.1371\/journal.pgen.1008097","journal-title":"PLoS Genet"},{"key":"12021_CR26","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.celrep.2013.06.035","volume":"4","author":"AE Webb","year":"2013","unstructured":"Webb AE, Pollina EA, Vierbuchen T, Urb\u00e1n N, Ucar D, Leeman DS et al (2013) FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis. Cell Rep 4:477\u2013491. https:\/\/doi.org\/10.1016\/j.celrep.2013.06.035","journal-title":"Cell Rep"},{"key":"12021_CR27","doi-asserted-by":"publisher","unstructured":"Ro SH, Liu D, Yeo H, Paik JH (2013) FoxOs in neural stem cell fate decision. In Archives of Biochemistry and Biophysics (Vol. 534, Numbers 1\u20132, pp. 55\u201363). https:\/\/doi.org\/10.1016\/j.abb.2012.07.017","DOI":"10.1016\/j.abb.2012.07.017"},{"key":"12021_CR28","doi-asserted-by":"publisher","unstructured":"Birnbaum A, Sodders M, Bouska M, Chang K, Kang P, McNeill E et al FOXO Regulates Neuromuscular Junction Homeostasis During Drosophila Aging. Front Aging Neurosci 2021;12. https:\/\/doi.org\/10.3389\/fnagi.2020.567861","DOI":"10.3389\/fnagi.2020.567861"},{"key":"12021_CR29","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1242\/dev.069062","volume":"138","author":"R Christensen","year":"2011","unstructured":"Christensen R, de la Torre-Ubieta L, Bonni A, Col\u00f3n-Ramos DA (2011) A conserved PTEN\/FOXO pathway regulates neuronal morphology during C. elegans development. Development 138:5257\u20135267. https:\/\/doi.org\/10.1242\/dev.069062","journal-title":"Development"},{"key":"12021_CR30","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1101\/gad.1880510","volume":"24","author":"L de la Torre-Ubieta","year":"2010","unstructured":"de la Torre-Ubieta L, Gaudilli\u00e8re B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S et al (2010) A FOXO\u2013Pak1 transcriptional pathway controls neuronal polarity. Genes Dev 24:799\u2013813. https:\/\/doi.org\/10.1101\/gad.1880510","journal-title":"Genes Dev"},{"key":"12021_CR31","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1242\/jcs.185009","volume":"129","author":"C Shi","year":"2016","unstructured":"Shi C, Viccaro K, Lee H, Shah K (2016) Cdk5\u2013Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer\u2019s disease models. J Cell Sci 129:1815\u20131830. https:\/\/doi.org\/10.1242\/jcs.185009","journal-title":"J Cell Sci"},{"issue":"6","key":"12021_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.04-3182fje","volume":"19","author":"Q Wang","year":"2005","unstructured":"Wang Q, Ho J, Qin L, Rocher W, Seror AB, Humala I, Maniar N, Dolios K, Wang G, Hof R, P. R., Pasinetti GM (2005) Caloric restriction attenuates \u03b2-amyloid neuropathology in a mouse model of Alzheimer\u2019s disease. FASEB J 19(6):1\u201318. https:\/\/doi.org\/10.1096\/fj.04-3182fje","journal-title":"FASEB J"},{"key":"12021_CR33","doi-asserted-by":"publisher","unstructured":"Venderova K, Park DS Programmed cell death in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2012;2. https:\/\/doi.org\/10.1101\/cshperspect.a009365","DOI":"10.1101\/cshperspect.a009365"},{"key":"12021_CR34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/jnc.14969","volume":"154","author":"P Sanphui","year":"2020","unstructured":"Sanphui P, Kumar Das A, Biswas SC (2020) Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI\/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson\u2019s disease. J Neurochem 154:547\u2013561. https:\/\/doi.org\/10.1111\/jnc.14969","journal-title":"J Neurochem"},{"key":"12021_CR35","doi-asserted-by":"publisher","first-page":"12630","DOI":"10.1523\/JNEUROSCI.0277-12.2012","volume":"32","author":"JA Parker","year":"2012","unstructured":"Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A et al (2012) Integration of \u03b2-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity. J Neurosci 32:12630\u201312640. https:\/\/doi.org\/10.1523\/JNEUROSCI.0277-12.2012","journal-title":"J Neurosci"},{"key":"12021_CR36","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3390\/md15080246","volume":"15","author":"M Boccitto","year":"2017","unstructured":"Boccitto M, Lee N, Sakamoto S, Spruce L, Handa H, Clardy J et al (2017) The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK. Mar Drugs 15:246. https:\/\/doi.org\/10.3390\/md15080246","journal-title":"Mar Drugs"},{"key":"12021_CR37","doi-asserted-by":"publisher","first-page":"8236","DOI":"10.1523\/JNEUROSCI.1805-09.2009","volume":"29","author":"J Mojsilovic-Petrovic","year":"2009","unstructured":"Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W et al (2009) FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases. J Neurosci 29:8236\u20138247. https:\/\/doi.org\/10.1523\/JNEUROSCI.1805-09.2009","journal-title":"J Neurosci"},{"key":"12021_CR38","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/j.1471-4159.2010.06687.x","volume":"113","author":"K Chang","year":"2010","unstructured":"Chang K, De Pablo Y, Lee H, Lee H, Smith MA, Shah K (2010) Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer\u2019s disease. J Neurochem 113:1221\u20131229. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.06687.x","journal-title":"J Neurochem"},{"key":"12021_CR39","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.bbamcr.2011.05.001","volume":"1813","author":"M Dobson","year":"2011","unstructured":"Dobson M, Ramakrishnan G, Ma S, Kaplun L, Balan V, Fridman R et al (2011) Bimodal regulation of FoxO3 by AKT and 14-3-3. Biochimica et Biophysica Acta (BBA) -. Mol Cell Res 1813:1453\u20131464. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.05.001","journal-title":"Mol Cell Res"},{"key":"12021_CR40","doi-asserted-by":"publisher","unstructured":"Asadi Y, Moundounga RK, Chakroborty A, Pokokiri A, Wang H FOXOs and their roles in acute and chronic neurological disorders. Front Mol Biosci 2025;12. https:\/\/doi.org\/10.3389\/fmolb.2025.1538472","DOI":"10.3389\/fmolb.2025.1538472"},{"key":"12021_CR41","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s40120-021-00271-2","volume":"10","author":"J Gu","year":"2021","unstructured":"Gu J, Li Z, Chen H, Xu X, Li Y, Gui Y (2021) Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial. Neurol Ther 10:905\u2013917. https:\/\/doi.org\/10.1007\/s40120-021-00271-2","journal-title":"Neurol Ther"},{"key":"12021_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/antiox14010070","volume":"14","author":"G Guan","year":"2025","unstructured":"Guan G, Chen Y, Dong Y (2025) Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases. Antioxidants 14:70. https:\/\/doi.org\/10.3390\/antiox14010070","journal-title":"Antioxidants"},{"key":"12021_CR43","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.2337\/db15-1428","volume":"65","author":"M Sajan","year":"2016","unstructured":"Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S et al (2016) Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1\u03b1 and Increases in A\u03b21\u201340\/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes 65:1892\u20131903. https:\/\/doi.org\/10.2337\/db15-1428","journal-title":"Diabetes"},{"key":"12021_CR44","doi-asserted-by":"publisher","first-page":"135322","DOI":"10.1016\/j.neulet.2020.135322","volume":"738","author":"W Zhang","year":"2020","unstructured":"Zhang W, Bai S, Yang J, Zhang Y, Liu Y, Nie J et al (2020) FoxO1 overexpression reduces A\u03b2 production and tau phosphorylation in vitro. Neurosci Lett 738:135322. https:\/\/doi.org\/10.1016\/j.neulet.2020.135322","journal-title":"Neurosci Lett"},{"key":"12021_CR45","doi-asserted-by":"crossref","unstructured":"Lin L, Hron JD, Peng SL (2004) Regulation of NF-B, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a. In Immunity (Vol. 21). http:\/\/www.immunity.com\/cgi\/content\/","DOI":"10.1016\/j.immuni.2004.06.016"},{"key":"12021_CR46","doi-asserted-by":"publisher","first-page":"e625","DOI":"10.1038\/cddis.2013.148","volume":"4","author":"P Sanphui","year":"2013","unstructured":"Sanphui P, Biswas SC (2013) FoxO3a is activated and executes neuron death via Bim in response to \u03b2-amyloid. Cell Death Dis 4:e625\u2013e625. https:\/\/doi.org\/10.1038\/cddis.2013.148","journal-title":"Cell Death Dis"},{"key":"12021_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/384094","volume":"2012","author":"L Moll","year":"2012","unstructured":"Moll L, Schubert M (2012) The Role of Insulin and Insulin-Like Growth Factor-1\/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Curr Gerontol Geriatr Res 2012:1\u201313. https:\/\/doi.org\/10.1155\/2012\/384094","journal-title":"Curr Gerontol Geriatr Res"},{"key":"12021_CR48","doi-asserted-by":"publisher","unstructured":"Kuznetsov AV Effect of diffusivity of amyloid beta monomers on the formation of senile plaques 2023. https:\/\/doi.org\/10.1101\/2023.07.31.551367","DOI":"10.1101\/2023.07.31.551367"},{"key":"12021_CR49","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1074\/jbc.R800018200","volume":"284","author":"BA Yankner","year":"2009","unstructured":"Yankner BA, Lu T (2009) Amyloid \u03b2-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 284:4755\u20134759. https:\/\/doi.org\/10.1074\/jbc.R800018200","journal-title":"J Biol Chem"},{"key":"12021_CR50","doi-asserted-by":"publisher","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0203-11.2011","volume":"31","author":"S Li","year":"2011","unstructured":"Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ (2011) Soluble a \u03b2 oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 31:6627\u20136638. https:\/\/doi.org\/10.1523\/JNEUROSCI.0203-11.2011","journal-title":"J Neurosci"},{"key":"12021_CR51","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1471-4159.2012.07877.x","volume":"123","author":"PK Bahia","year":"2012","unstructured":"Bahia PK, Pugh V, Hoyland K, Hensley V, Rattray M, Williams RJ (2012) Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem 123:182\u2013191. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07877.x","journal-title":"J Neurochem"},{"issue":"6","key":"12021_CR52","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10495-008-0218-5","volume":"13","author":"B Cai","year":"2008","unstructured":"Cai B, Xia Z (2008) p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis 13(6):803\u2013810. https:\/\/doi.org\/10.1007\/s10495-008-0218-5","journal-title":"Apoptosis"},{"key":"12021_CR53","doi-asserted-by":"publisher","unstructured":"Zhang W, Shi Y, Lv M, Zhang Y, Ren W, Shi R et al (2023) Physalin B Reduces Tau Phosphorylation and Cell Apoptosis in HEK293 Cells by Activating FoxO1. Curr Mol Pharmacol 17. https:\/\/doi.org\/10.2174\/1874467217666230721124057","DOI":"10.2174\/1874467217666230721124057"},{"key":"12021_CR54","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.stem.2009.09.014","volume":"5","author":"VM Renault","year":"2009","unstructured":"Renault VM, Rafalski VA, Morgan AA, Salih DAM, Brett JO, Webb AE et al (2009) FoxO3 Regulates Neural Stem Cell Homeostasis. Cell Stem Cell 5:527\u2013539. https:\/\/doi.org\/10.1016\/j.stem.2009.09.014","journal-title":"Cell Stem Cell"},{"key":"12021_CR55","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.tig.2017.10.002","volume":"34","author":"CN McLaughlin","year":"2018","unstructured":"McLaughlin CN, Broihier HT (2018) Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity. Trends Genet 34:65\u201378. https:\/\/doi.org\/10.1016\/j.tig.2017.10.002","journal-title":"Trends Genet"},{"key":"12021_CR56","doi-asserted-by":"publisher","unstructured":"Nowak K, Killmer K, Gessner C, Lutz W E2F-1 regulates expression of FOXO1 and FOXO3a. Biochimica et Biophysica Acta - Gene Structure and Expression 2007;1769. https:\/\/doi.org\/10.1016\/j.bbaexp.2007.04.001","DOI":"10.1016\/j.bbaexp.2007.04.001"},{"key":"12021_CR57","doi-asserted-by":"publisher","first-page":"e73875","DOI":"10.1371\/journal.pone.0073875","volume":"8","author":"YS Hori","year":"2013","unstructured":"Hori YS, Kuno A, Hosoda R, Horio Y (2013) Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress. PLoS ONE 8:e73875. https:\/\/doi.org\/10.1371\/journal.pone.0073875","journal-title":"PLoS ONE"},{"key":"12021_CR58","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/BCJ20210777","volume":"479","author":"Z Cheng","year":"2022","unstructured":"Cheng Z (2022) FoxO transcription factors in mitochondrial homeostasis. Biochem J 479:525\u2013536. https:\/\/doi.org\/10.1042\/BCJ20210777","journal-title":"Biochem J"},{"key":"12021_CR59","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1111\/febs.12949","volume":"281","author":"H Yun","year":"2014","unstructured":"Yun H, Park S, Kim M, Yang WK, Im DU, Yang KR et al (2014) <scp\u2009>\u2009AMP -activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1<\/scp\u2009>. FEBS J 281:4421\u20134438. https:\/\/doi.org\/10.1111\/febs.12949","journal-title":"FEBS J"},{"key":"12021_CR60","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/glia.21134","volume":"59","author":"M Cui","year":"2011","unstructured":"Cui M, Huang Y, Tian C, Zhao Y, Zheng J (2011) FOXO3a inhibits TNF-\u03b1\u2010 and IL\u20101\u03b2\u2010induced astrocyte proliferation:Implication for reactive astrogliosis. Glia 59:641\u2013654. https:\/\/doi.org\/10.1002\/glia.21134","journal-title":"Glia"},{"key":"12021_CR61","doi-asserted-by":"publisher","unstructured":"Sanchez-Garcia MA, Lara-Ure\u00f1a N, March-Diaz R, Ortega-de San Luis C, Qui\u00f1ones-Ca\u00f1ete S, Mora-Romero B et al (2025) Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer\u2019s disease progression. Sci Adv 11. https:\/\/doi.org\/10.1126\/sciadv.adu2244","DOI":"10.1126\/sciadv.adu2244"},{"key":"12021_CR62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2174\/156720209787466064","volume":"6","author":"Y Shang","year":"2009","unstructured":"Shang Y, Chong Z, Hou J, Maiese K (2009) The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3. Curr Neurovasc Res 6:20\u201331. https:\/\/doi.org\/10.2174\/156720209787466064","journal-title":"Curr Neurovasc Res"},{"key":"12021_CR63","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.immuni.2004.06.016","volume":"21","author":"L Lin","year":"2004","unstructured":"Lin L, Hron JD, Peng SL (2004) Regulation of NF-\u03baB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a. Immunity 21:203\u2013213. https:\/\/doi.org\/10.1016\/j.immuni.2004.06.016","journal-title":"Immunity"},{"key":"12021_CR64","doi-asserted-by":"publisher","first-page":"9138","DOI":"10.1128\/MCB.20.24.9138-9148.2000","volume":"20","author":"PF Dijkers","year":"2000","unstructured":"Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NSB, Lam EW-F et al (2000) Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27 KIP1. Mol Cell Biol 20:9138\u20139148. https:\/\/doi.org\/10.1128\/MCB.20.24.9138-9148.2000","journal-title":"Mol Cell Biol"},{"key":"12021_CR65","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1038\/s41593-024-01737-w","volume":"27","author":"A Pichet Binette","year":"2024","unstructured":"Pichet Binette A, Gaiteri C, Wennstr\u00f6m M, Kumar A, Hristovska I, Spotorno N et al (2024) Proteomic changes in Alzheimer\u2019s disease associated with progressive A\u03b2 plaque and tau tangle pathologies. Nat Neurosci 27:1880\u20131891. https:\/\/doi.org\/10.1038\/s41593-024-01737-w","journal-title":"Nat Neurosci"},{"key":"12021_CR66","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.neuint.2006.10.002","volume":"50","author":"N Crespo-Biel","year":"2007","unstructured":"Crespo-Biel N, Canudas AM, Camins A, Pall\u00e0s M (2007) Kainate induces AKT, ERK and cdk5\/GSK3\u03b2 pathway deregulation, phosphorylates tau protein in mouse hippocampus. Neurochem Int 50:435\u2013442. https:\/\/doi.org\/10.1016\/j.neuint.2006.10.002","journal-title":"Neurochem Int"},{"key":"12021_CR67","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12974-019-1474-8","volume":"16","author":"L-T Guo","year":"2019","unstructured":"Guo L-T, Wang S-Q, Su J, Xu L-X, Ji Z-Y, Zhang R-Y et al (2019) Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway. J Neuroinflammation 16:95. https:\/\/doi.org\/10.1186\/s12974-019-1474-8","journal-title":"J Neuroinflammation"},{"key":"12021_CR68","doi-asserted-by":"publisher","first-page":"15982","DOI":"10.1074\/jbc.274.23.15982","volume":"274","author":"J Nakae","year":"1999","unstructured":"Nakae J, Park B-C, Accili D (1999) Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway. J Biol Chem 274:15982\u201315985. https:\/\/doi.org\/10.1074\/jbc.274.23.15982","journal-title":"J Biol Chem"},{"key":"12021_CR69","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/alzrt265","volume":"6","author":"Y Kitagishi","year":"2014","unstructured":"Kitagishi Y, Nakanishi A, Ogura Y, Matsuda S (2014) Dietary regulation of PI3K\/AKT\/GSK-3\u03b2 pathway in Alzheimer\u2019s disease. Alzheimers Res Ther 6:35. https:\/\/doi.org\/10.1186\/alzrt265","journal-title":"Alzheimers Res Ther"},{"key":"12021_CR70","doi-asserted-by":"publisher","unstructured":"Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: The in vivo evidence. In Nature Reviews Drug Discovery (Vol. 5, Number 6, pp. 493\u2013506). https:\/\/doi.org\/10.1038\/nrd2060","DOI":"10.1038\/nrd2060"},{"issue":"3","key":"12021_CR71","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10863-016-9645-0","volume":"48","author":"C Shi","year":"2016","unstructured":"Shi C, Zhu J, Leng S, Long D, Luo X (2016) Mitochondrial FOXO3a is involved in amyloid \u03b2 peptide-induced mitochondrial dysfunction. J Bioenerg Biomembr 48(3):189\u2013196. https:\/\/doi.org\/10.1007\/s10863-016-9645-0","journal-title":"J Bioenerg Biomembr"},{"key":"12021_CR72","doi-asserted-by":"publisher","unstructured":"Liu L, Bai J, Liu F, Xu Y, Zhao M, Zhao C et al Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer\u2019s Disease and Huntington\u2019s Disease. Oxid Med Cell Longev 2022;2022. https:\/\/doi.org\/10.1155\/2022\/7619255","DOI":"10.1155\/2022\/7619255"},{"key":"12021_CR73","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00011-025-02118-0","volume":"74","author":"N Lior","year":"2025","unstructured":"Lior N, Chen D, Dan F, Ronit P-K (2025) The connection between autophagy and Alzheimer\u2019s disease. Inflamm Res 74:148. https:\/\/doi.org\/10.1007\/s00011-025-02118-0","journal-title":"Inflamm Res"},{"key":"12021_CR74","doi-asserted-by":"publisher","unstructured":"Xia Y, Qadota H, Wang Z-H, Liu P, Liu X, Ye KX et al (2022) Neuronal C\/EBP\u03b2\/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Sci Adv 8. https:\/\/doi.org\/10.1126\/sciadv.abj8658","DOI":"10.1126\/sciadv.abj8658"},{"key":"12021_CR75","doi-asserted-by":"publisher","unstructured":"Lv M, Wang H, Meng X, Shi Y, Zhang Y, Shan L et al (2024) In silico and in vitro analyses of a novel\u2009<\u2009scp>FoxO1 agonist reducing A\u03b2 levels via downregulation of <\u2009scp>BACE1. CNS Neurosci Ther 30. https:\/\/doi.org\/10.1111\/cns.14140","DOI":"10.1111\/cns.14140"},{"key":"12021_CR76","doi-asserted-by":"publisher","first-page":"111290","DOI":"10.1016\/j.mad.2020.111290","volume":"190","author":"R Pradhan","year":"2020","unstructured":"Pradhan R, Yadav SK, Prem NN, Bhagel V, Pathak M, Shekhar S et al (2020) Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer\u2019s disease. Mech Ageing Dev 190:111290. https:\/\/doi.org\/10.1016\/j.mad.2020.111290","journal-title":"Mech Ageing Dev"},{"key":"12021_CR77","doi-asserted-by":"publisher","unstructured":"Hao H, Bai Y, Liu Y, Liang J, Guo S (2021) Protective mechanism of FoxO1 against early brain injury after subarachnoid hemorrhage by regulating autophagy. Brain Behav 11. https:\/\/doi.org\/10.1002\/brb3.2376","DOI":"10.1002\/brb3.2376"},{"key":"12021_CR78","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12974-014-0140-4","volume":"11","author":"H Dong","year":"2014","unstructured":"Dong H, Zhang X, Dai X, Lu S, Gui B, Jin W et al (2014) Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K\/Akt\/FoxO1 pathway. J Neuroinflammation 11:140. https:\/\/doi.org\/10.1186\/s12974-014-0140-4","journal-title":"J Neuroinflammation"},{"key":"12021_CR79","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neulet.2015.10.001","volume":"609","author":"A Fluteau","year":"2015","unstructured":"Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ et al (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neurosci Lett 609:11\u201317. https:\/\/doi.org\/10.1016\/j.neulet.2015.10.001","journal-title":"Neurosci Lett"},{"key":"12021_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/316523","volume":"2013","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Zhao B (2013) Oxidative Stress and the Pathogenesis of Alzheimer\u2019s Disease. Oxid Med Cell Longev 2013:1\u201310. https:\/\/doi.org\/10.1155\/2013\/316523","journal-title":"Oxid Med Cell Longev"},{"key":"12021_CR81","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","volume":"30","author":"Z Chen","year":"2014","unstructured":"Chen Z, Zhong C (2014) Oxidative stress in Alzheimer\u2019s disease. Neurosci Bull 30:271\u2013281. https:\/\/doi.org\/10.1007\/s12264-013-1423-y","journal-title":"Neurosci Bull"},{"key":"12021_CR82","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13064-025-00210-z","volume":"20","author":"J Cui","year":"2025","unstructured":"Cui J, Zhao C (2025) Autophagy and apoptosis in Alzheimer\u2019s disease-associated neurons. Discover Neurosci 20:11. https:\/\/doi.org\/10.1186\/s13064-025-00210-z","journal-title":"Discover Neurosci"},{"key":"12021_CR83","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2353\/ajpath.2008.071176","volume":"173","author":"D-S Yang","year":"2008","unstructured":"Yang D-S, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M et al (2008) Neuronal Apoptosis and Autophagy Cross Talk in Aging PS\/APP Mice, a Model of Alzheimer\u2019s Disease. Am J Pathol 173:665\u2013681. https:\/\/doi.org\/10.2353\/ajpath.2008.071176","journal-title":"Am J Pathol"},{"key":"12021_CR84","doi-asserted-by":"publisher","unstructured":"Iside C, Scafuro M, Nebbioso A, Altucci L (2020) SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol 11. https:\/\/doi.org\/10.3389\/fphar.2020.01225","DOI":"10.3389\/fphar.2020.01225"},{"key":"12021_CR85","doi-asserted-by":"publisher","first-page":"521","DOI":"10.14336\/AD.2021.0826","volume":"13","author":"S Guo","year":"2022","unstructured":"Guo S, Mangal R, Dandu C, Geng X, Ding Y (2022) Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review. Aging Dis 13:521. https:\/\/doi.org\/10.14336\/AD.2021.0826","journal-title":"Aging Dis"},{"issue":"10","key":"12021_CR86","doi-asserted-by":"publisher","first-page":"13967","DOI":"10.1007\/s00210-025-04017-x","volume":"398","author":"A Bishr","year":"2025","unstructured":"Bishr A, Atwa AM, El-Mokadem BM, El-Din MN (2025) Canagliflozin potentially promotes renal protection against glycerol-induced acute kidney injury by activating the AMPK\/SIRT1\/FOXO-3a\/PGC-1\u03b1 and Nrf2\/HO-1 pathways. Naunyn-Schmiedeberg\u2019s Archives Pharmacol 398(10):13967\u201313979. https:\/\/doi.org\/10.1007\/s00210-025-04017-x","journal-title":"Naunyn-Schmiedeberg\u2019s Archives Pharmacol"},{"key":"12021_CR87","doi-asserted-by":"publisher","first-page":"241","DOI":"10.15761\/JTS.1000146","volume":"2","author":"K Maiese","year":"2016","unstructured":"Maiese K (2016) Forkhead transcription factors: new considerations for alzheimer\u2019s disease and dementia. J Transl Sci 2:241\u2013247. https:\/\/doi.org\/10.15761\/JTS.1000146","journal-title":"J Transl Sci"},{"key":"12021_CR88","doi-asserted-by":"publisher","first-page":"101621","DOI":"10.1016\/j.arr.2022.101621","volume":"78","author":"RL McIntyre","year":"2022","unstructured":"McIntyre RL, Liu YJ, Hu M, Morris BJ, Willcox BJ, Donlon TA et al (2022) Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity. Ageing Res Rev 78:101621. https:\/\/doi.org\/10.1016\/j.arr.2022.101621","journal-title":"Ageing Res Rev"},{"key":"12021_CR89","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1093\/gerona\/glab265","volume":"77","author":"L Jimenez","year":"2022","unstructured":"Jimenez L, Silva A, Calissi G, Grenho I, Monteiro R, Mayoral-Varo V et al (2022) Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3. Journals Gerontology: Ser A 77:1485\u20131493. https:\/\/doi.org\/10.1093\/gerona\/glab265","journal-title":"Journals Gerontology: Ser A"},{"key":"12021_CR90","doi-asserted-by":"publisher","first-page":"9701","DOI":"10.18632\/oncotarget.3832","volume":"6","author":"J-H Lee","year":"2015","unstructured":"Lee J-H, Moon J-H, Kim S-W, Jeong J-K, Nazim UMD, Lee Y-J et al (2015) EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells. Oncotarget 6:9701\u20139717. https:\/\/doi.org\/10.18632\/oncotarget.3832","journal-title":"Oncotarget"},{"key":"12021_CR91","doi-asserted-by":"publisher","first-page":"105613","DOI":"10.1016\/j.neuint.2023.105613","volume":"171","author":"T Murata","year":"2023","unstructured":"Murata T, Ishiwa S, Lin X, Nakazawa Y, Tago K, Funakoshi-Tago M (2023) The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-\u03baB. Neurochem Int 171:105613. https:\/\/doi.org\/10.1016\/j.neuint.2023.105613","journal-title":"Neurochem Int"},{"key":"12021_CR92","doi-asserted-by":"publisher","first-page":"30107","DOI":"10.1074\/jbc.M705325200","volume":"282","author":"EL Greer","year":"2007","unstructured":"Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP et al (2007) The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor. J Biol Chem 282:30107\u201330119. https:\/\/doi.org\/10.1074\/jbc.M705325200","journal-title":"J Biol Chem"},{"key":"12021_CR93","doi-asserted-by":"publisher","first-page":"106443","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106443","volume":"31","author":"B Wang","year":"2022","unstructured":"Wang B, Zhao X, Xiao L, Chen Y (2022) FoxO1 Silencing Facilitates Neurological Function Recovery in Intracerebral Hemorrhage Mice via the lncRNA GAS5\/miR-378a-5p\/Hspa5 Axis. J Stroke Cerebrovasc Dis 31:106443. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2022.106443","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"11","key":"12021_CR94","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1111\/jcmm.16537","volume":"25","author":"J Shen","year":"2021","unstructured":"Shen J, Li G, Zhu Y, Xu Q, Zhou H, Xu K et al (2021) Foxo1-induced miR-92b down-regulation promotes blood-brain barrier damage after ischaemic stroke by targeting NOX4. J Cell Mol Med 25(11):5269\u20135282. https:\/\/doi.org\/10.1111\/jcmm.16537 PubMed PMID: 33955666","journal-title":"J Cell Mol Med"},{"key":"12021_CR95","doi-asserted-by":"publisher","unstructured":"Maiese K (2021) Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1. Neural Regen Res. ;16:448\u201355. https:\/\/doi.org\/10.4103\/1673-5374.291382","DOI":"10.4103\/1673-5374.291382"},{"key":"12021_CR96","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41388-019-1044-7","volume":"39","author":"S Salcher","year":"2020","unstructured":"Salcher S, Spoden G, Hagenbuchner J, F\u00fchrer S, Kaserer T, Tollinger M et al (2020) A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma. Oncogene 39:1080\u20131097. https:\/\/doi.org\/10.1038\/s41388-019-1044-7","journal-title":"Oncogene"},{"key":"12021_CR97","doi-asserted-by":"publisher","unstructured":"Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I et al (2021) An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Mol Metab 54. https:\/\/doi.org\/10.1016\/j.molmet.2021.101329","DOI":"10.1016\/j.molmet.2021.101329"},{"key":"12021_CR98","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/onc.2011.368","volume":"31","author":"CT Karadedou","year":"2012","unstructured":"Karadedou CT, Gomes AR, Chen J, Petkovic M, Ho K-K, Zwolinska AK et al (2012) FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene 31:1845\u20131858. https:\/\/doi.org\/10.1038\/onc.2011.368","journal-title":"Oncogene"},{"key":"12021_CR99","doi-asserted-by":"publisher","first-page":"5886","DOI":"10.1128\/MCB.01265-07","volume":"28","author":"RC-Y Hui","year":"2008","unstructured":"Hui RC-Y, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S et al (2008) The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase\/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression. Mol Cell Biol 28:5886\u20135898. https:\/\/doi.org\/10.1128\/MCB.01265-07","journal-title":"Mol Cell Biol"},{"key":"12021_CR100","doi-asserted-by":"publisher","unstructured":"Park S-H, Chung YM, Ma J, Yang Q, Berek JS, Hu MC-T Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo. Oncotarget 2106;7:42110\u201342125. https:\/\/doi.org\/10.18632\/oncotarget.9881","DOI":"10.18632\/oncotarget.9881"},{"key":"12021_CR101","doi-asserted-by":"publisher","first-page":"174011","DOI":"10.1016\/j.ejphar.2021.174011","volume":"899","author":"H-E Choi","year":"2021","unstructured":"Choi H-E, Kim Y, Lee H-J, Cheon HG (2021) Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model. Eur J Pharmacol 899:174011. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174011","journal-title":"Eur J Pharmacol"},{"key":"12021_CR102","doi-asserted-by":"publisher","unstructured":"Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S et al Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Cell Death Dis 2023;14. https:\/\/doi.org\/10.1038\/s41419-023-06168-2","DOI":"10.1038\/s41419-023-06168-2"},{"key":"12021_CR103","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1074\/jbc.M209677200","volume":"278","author":"JR Burke","year":"2003","unstructured":"Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW et al (2003) BMS-345541 Is a Highly Selective Inhibitor of I\u03baB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-\u03baB-dependent Transcription in Mice. J Biol Chem 278:1450\u20131456. https:\/\/doi.org\/10.1074\/jbc.M209677200","journal-title":"J Biol Chem"},{"key":"12021_CR104","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/s12276-021-00655-2","volume":"53","author":"H-F Yu","year":"2021","unstructured":"Yu H-F, Zheng L-W, Yang Z-Q, Wang Y-S, Wang T-T, Yue Z-P et al (2021) TAZ as a novel regulator of oxidative damage in decidualization via Nrf2\/ARE\/Foxo1 pathway. Exp Mol Med 53:1307\u20131318. https:\/\/doi.org\/10.1038\/s12276-021-00655-2","journal-title":"Exp Mol Med"},{"key":"12021_CR105","unstructured":"Lu H, Huang H FOXO1: A potential target for human diseases. n.d"},{"key":"12021_CR106","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1042\/BJ20140831","volume":"469","author":"DEA Kloet","year":"2015","unstructured":"Kloet DEA, Polderman PE, Eijkelenboom A, Smits LM, Van Triest MH, Van Den Berg MCW et al (2015) FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21Cip1\/Waf1. Biochem J 469:289\u2013298. https:\/\/doi.org\/10.1042\/BJ20140831","journal-title":"Biochem J"},{"key":"12021_CR107","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.ccell.2023.04.019","volume":"41","author":"L Wang","year":"2023","unstructured":"Wang L, Dou X, Chen S, Yu X, Huang X, Zhang L et al (2023) YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Cancer Cell 41:1294\u20131308e8. https:\/\/doi.org\/10.1016\/j.ccell.2023.04.019","journal-title":"Cancer Cell"},{"key":"12021_CR108","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s11033-025-10436-z","volume":"52","author":"M Shyam","year":"2025","unstructured":"Shyam M, BM O, Srirangan P, Sabina NN (2025) Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential. Mol Biol Rep 52:368. https:\/\/doi.org\/10.1007\/s11033-025-10436-z","journal-title":"Mol Biol Rep"},{"key":"12021_CR109","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s11064-021-03490-z","volume":"47","author":"Q Pan","year":"2022","unstructured":"Pan Q, Ma J, Guo K (2022) miR-223 Enhances the Neuroprotection of Estradiol Against Oxidative Stress Injury by Inhibiting the FOXO3\/TXNIP Axis. Neurochem Res 47:1865\u20131877. https:\/\/doi.org\/10.1007\/s11064-021-03490-z","journal-title":"Neurochem Res"},{"key":"12021_CR110","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1212\/01.wnl.0000437306.37850.22","volume":"81","author":"C Sala Frigerio","year":"2013","unstructured":"Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R et al (2013) Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology 81:2103\u20132106. https:\/\/doi.org\/10.1212\/01.wnl.0000437306.37850.22","journal-title":"Neurology"},{"key":"12021_CR111","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.bbrc.2016.12.001","volume":"482","author":"L Sun","year":"2017","unstructured":"Sun L, Zhao M, Wang Y, Liu A, Lv M, Li Y et al (2017) Neuroprotective effects of miR-27a against traumatic brain injury via suppressing FoxO3a-mediated neuronal autophagy. Biochem Biophys Res Commun 482:1141\u20131147. https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.001","journal-title":"Biochem Biophys Res Commun"},{"key":"12021_CR112","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2217\/epi-2019-0215","volume":"12","author":"B-W Wu","year":"2020","unstructured":"Wu B-W, Guo J-D, Wu M-S, Liu Y, Lu M, Zhou Y-H et al (2020) Osteoblast-Derived Lipocalin-2 Regulated by miRNA-96-5p\/Foxo1 Advances the Progression of Alzheimer\u2019s Disease. Epigenomics 12:1501\u20131513. https:\/\/doi.org\/10.2217\/epi-2019-0215","journal-title":"Epigenomics"},{"key":"12021_CR113","doi-asserted-by":"publisher","unstructured":"Gu\u00e9vremont D, Tsui H, Knight R, Fowler CJ, Masters CL, Martins RN et al (2022) Plasma microRNA vary in association with the progression of Alzheimer\u2019s disease. Alzheimer\u2019s Dementia: Diagnosis Assess Disease Monit 14. https:\/\/doi.org\/10.1002\/dad2.12251","DOI":"10.1002\/dad2.12251"},{"key":"12021_CR114","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1523\/JNEUROSCI.2444-14.2015","volume":"35","author":"S Peng","year":"2015","unstructured":"Peng S, Zhao S, Yan F, Cheng J, Huang L, Chen H et al (2015) HDAC2 Selectively Regulates FOXO3a-Mediated Gene Transcription during Oxidative Stress-Induced Neuronal Cell Death. J Neurosci 35:1250\u20131259. https:\/\/doi.org\/10.1523\/JNEUROSCI.2444-14.2015","journal-title":"J Neurosci"},{"key":"12021_CR115","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/jnr.10845","volume":"75","author":"H Kim","year":"2004","unstructured":"Kim H, Kim E, Kim N, Chang K, Choi Y, Ahn K et al (2004) Inhibition of histone deacetylation enhances the neurotoxicity induced by the c-terminal fragments of amyloid precursor protein. J Neurosci Res 75:117\u2013124. https:\/\/doi.org\/10.1002\/jnr.10845","journal-title":"J Neurosci Res"},{"key":"12021_CR116","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10238-022-00831-2","volume":"23","author":"S Xu","year":"2022","unstructured":"Xu S, Zhang X, Wang X, Xie H, Wang F, Zhou T et al (2022) DNA methylation and transcription of the FOXO3a gene are associated with ankylosing spondylitis. Clin Exp Med 23:483\u2013493. https:\/\/doi.org\/10.1007\/s10238-022-00831-2","journal-title":"Clin Exp Med"},{"key":"12021_CR117","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuropharm.2016.01.025","volume":"105","author":"S Sharma","year":"2016","unstructured":"Sharma S, Taliyan R (2016) Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice. Neuropharmacology 105:285\u2013297. https:\/\/doi.org\/10.1016\/j.neuropharm.2016.01.025","journal-title":"Neuropharmacology"},{"key":"12021_CR118","doi-asserted-by":"publisher","unstructured":"Nan S, Wang P, Zhang Y, Fan J Epigallocatechin-3-Gallate Provides Protection Against Alzheimer\u2019s Disease-Induced Learning and Memory Impairments in Rats. Drug Des Devel Ther 2021;Volume 15:2013\u20132024. https:\/\/doi.org\/10.2147\/DDDT.S289473","DOI":"10.2147\/DDDT.S289473"},{"key":"12021_CR119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-31143-2_70-1","volume-title":"Handbook of Nutrition, Diet, and Epigenetics","author":"S Khan","year":"2017","unstructured":"Khan S, Maremanda KP, Jena G (2017) Butyrate, a Short-Chain Fatty Acid and Histone Deacetylases Inhibitor: Nutritional, Physiological, and Pharmacological Aspects in Diabetes. Handbook of Nutrition, Diet, and Epigenetics. Springer International Publishing, Cham, pp 1\u201315. https:\/\/doi.org\/10.1007\/978-3-319-31143-2_70-1."},{"key":"12021_CR120","doi-asserted-by":"publisher","first-page":"492S","DOI":"10.1080\/07315724.2009.10718116","volume":"28","author":"L Romeo","year":"2009","unstructured":"Romeo L, Intrieri M, D\u2019Agata V, Mangano NG, Oriani G, Ontario ML et al (2009) The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Induces Heme Oxygenase in Rat Neurons and Acts as an Effective Neuroprotective Agent against Oxidative Stress. J Am Coll Nutr 28:492S\u2013499S. https:\/\/doi.org\/10.1080\/07315724.2009.10718116","journal-title":"J Am Coll Nutr"},{"key":"12021_CR121","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbrc.2021.03.122","volume":"554","author":"H Qin","year":"2021","unstructured":"Qin H, Zhang H, Zhang X, Zhang S, Zhu S, Wang H (2021) Resveratrol attenuates radiation enteritis through the SIRT1\/FOXO3a and PI3K\/AKT signaling pathways. Biochem Biophys Res Commun 554:199\u2013205. https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.122","journal-title":"Biochem Biophys Res Commun"},{"key":"12021_CR122","doi-asserted-by":"publisher","unstructured":"Elbini-Dhouib I, Doghri R, Ellefi A, Degrach I, Srairi-Abid N, Gati A Curcumin attenuated neurotoxicity in sporadic animal model of alzheimer\u2019s disease. Molecules 2021;26. https:\/\/doi.org\/10.3390\/molecules26103011","DOI":"10.3390\/molecules26103011"},{"key":"12021_CR123","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1128\/MCB.22.7.2025-2036.2002","volume":"22","author":"GJPL Kops","year":"2002","unstructured":"Kops GJPL, Medema RH, Glassford J, Essers MAG, Dijkers PF, Coffer PJ et al (2002) Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors. Mol Cell Biol 22:2025\u20132036. https:\/\/doi.org\/10.1128\/MCB.22.7.2025-2036.2002","journal-title":"Mol Cell Biol"},{"key":"12021_CR124","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1750-1326-9-33","volume":"9","author":"V Landel","year":"2014","unstructured":"Landel V, Baranger K, Virard I, Loriod B, Khrestchatisky M, Rivera S et al (2014) Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer\u2019s disease. Mol Neurodegener 9:33. https:\/\/doi.org\/10.1186\/1750-1326-9-33","journal-title":"Mol Neurodegener"},{"key":"12021_CR125","doi-asserted-by":"publisher","unstructured":"Du S, Jin F, Maneix L, Gedam M, Xu Y, Catic A et al (2021) FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology. Aging Cell 20. https:\/\/doi.org\/10.1111\/acel.13432","DOI":"10.1111\/acel.13432"},{"key":"12021_CR126","doi-asserted-by":"publisher","unstructured":"Santo EE, Paik J (2018) FOXO in Neural Cells and Diseases of the Nervous System. 105\u2013118. https:\/\/doi.org\/10.1016\/bs.ctdb.2017.10.002","DOI":"10.1016\/bs.ctdb.2017.10.002"},{"key":"12021_CR127","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bbrc.2012.01.122","volume":"419","author":"YK Hong","year":"2012","unstructured":"Hong YK, Lee S, Park SH, Lee JH, Han SY, Kim ST et al (2012) Inhibition of JNK\/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer\u2019s disease model. Biochem Biophys Res Commun 419:49\u201353. https:\/\/doi.org\/10.1016\/j.bbrc.2012.01.122","journal-title":"Biochem Biophys Res Commun"},{"key":"12021_CR128","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/2211-5463.12773","volume":"10","author":"L Bergkvist","year":"2020","unstructured":"Bergkvist L, Du Z, Elovsson G, Appelqvist H, Itzhaki LS, Kumita JR et al (2020) Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer\u2019s disease. FEBS Open Bio 10:338\u2013350. https:\/\/doi.org\/10.1002\/2211-5463.12773","journal-title":"FEBS Open Bio"},{"key":"12021_CR129","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1073\/pnas.0807991106","volume":"106","author":"Y Chen","year":"2009","unstructured":"Chen Y, Zhou K, Wang R, Liu Y, Kwak Y-D, Ma T et al (2009) Antidiabetic drug metformin (Glucophage R) increases biogenesis of Alzheimer\u2019s amyloid peptides via up-regulating BACE1 transcription. Proc Natl Acad Sci 106:3907\u20133912. https:\/\/doi.org\/10.1073\/pnas.0807991106","journal-title":"Proc Natl Acad Sci"},{"key":"12021_CR130","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3233\/JAD-180263","volume":"65","author":"JM Campbell","year":"2018","unstructured":"Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (2018) Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis. J Alzheimer\u2019s Disease 65:1225\u20131236. https:\/\/doi.org\/10.3233\/JAD-180263","journal-title":"J Alzheimer\u2019s Disease"},{"key":"12021_CR131","doi-asserted-by":"publisher","first-page":"40242","DOI":"10.1074\/jbc.M608116200","volume":"281","author":"Y Cao","year":"2006","unstructured":"Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M et al (2006) Interaction of FoxO1 and TSC2 Induces Insulin Resistance through Activation of the Mammalian Target of Rapamycin\/p70 S6K Pathway. J Biol Chem 281:40242\u201340251. https:\/\/doi.org\/10.1074\/jbc.M608116200","journal-title":"J Biol Chem"},{"key":"12021_CR132","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature08221","volume":"460","author":"DE Harrison","year":"2009","unstructured":"Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K et al (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392\u2013395. https:\/\/doi.org\/10.1038\/nature08221","journal-title":"Nature"},{"key":"12021_CR133","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","volume":"85","author":"RS Turner","year":"2015","unstructured":"Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA et al (2015) A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology 85:1383\u20131391. https:\/\/doi.org\/10.1212\/WNL.0000000000002035","journal-title":"Neurology"},{"key":"12021_CR134","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/1471-2148-9-222","volume":"9","author":"M Wang","year":"2009","unstructured":"Wang M, Zhang X, Zhao H, Wang Q, Pan Y (2009) FoxO gene family evolution in vertebrates. BMC Evol Biol 9:222. https:\/\/doi.org\/10.1186\/1471-2148-9-222","journal-title":"BMC Evol Biol"},{"key":"12021_CR135","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.molcel.2007.10.035","volume":"28","author":"WJ Bakker","year":"2007","unstructured":"Bakker WJ, Harris IS, Mak TW (2007) FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2. Mol Cell 28:941\u2013953. https:\/\/doi.org\/10.1016\/j.molcel.2007.10.035","journal-title":"Mol Cell"},{"key":"12021_CR136","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/j.1749-6632.2009.04019.x","volume":"1170","author":"EL Greer","year":"2009","unstructured":"Greer EL, Banko MR, Brunet A (2009) AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction\u2013induced Longevity. Ann N Y Acad Sci 1170:688\u2013692. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04019.x","journal-title":"Ann N Y Acad Sci"},{"key":"12021_CR137","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1023\/A:1012098005098","volume":"14","author":"RN Alyautdin","year":"1997","unstructured":"Alyautdin RN, Petrov VE, Langer K, Berthold A, Kharkevich DA, Kreuter J (1997) Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles. Pharm Res 14:325\u2013328. https:\/\/doi.org\/10.1023\/A:1012098005098","journal-title":"Pharm Res"},{"key":"12021_CR138","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1124\/dmd.32.1.132","volume":"32","author":"X Liu","year":"2004","unstructured":"Liu X, Tu M, Kelly RS, Chen C, Smith BJ, DEVELOPMENT OF A COMPUTATIONAL APPROACH TO, PREDICT BLOOD-BRAIN BARRIER PERMEABILITY (2004) Drug Metab Dispos 32:132\u2013139. https:\/\/doi.org\/10.1124\/dmd.32.1.132","journal-title":"Drug Metab Dispos"},{"key":"12021_CR139","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1038\/bjc.2015.373","volume":"113","author":"E Geuna","year":"2015","unstructured":"Geuna E, Roda D, Rafii S, Jimenez B, Capelan M, Rihawi K et al (2015) Complications of hyperglycaemia with PI3K\u2013AKT\u2013mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials. Br J Cancer 113:1541\u20131547. https:\/\/doi.org\/10.1038\/bjc.2015.373","journal-title":"Br J Cancer"},{"key":"12021_CR140","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1002\/cam4.4579","volume":"11","author":"D Liu","year":"2022","unstructured":"Liu D, Weintraub MA, Garcia C, Goncalves MD, Sisk AE, Casas A et al (2022) Characterization, management, and risk factors of hyperglycemia during <\u2009scp>PI3K\u2009or <scp\u2009>\u2009AKT inhibitor treatment<\/scp\u2009>. Cancer Med 11:1796\u20131804. https:\/\/doi.org\/10.1002\/cam4.4579","journal-title":"Cancer Med"},{"key":"12021_CR141","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1111\/j.1460-9568.2006.04859.x","volume":"23","author":"JM Horwood","year":"2006","unstructured":"Horwood JM, Dufour F, Laroche S, Davis S (2006) Signalling mechanisms mediated by the phosphoinositide 3-kinase\/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 23:3375\u20133384. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04859.x","journal-title":"Eur J Neurosci"},{"key":"12021_CR142","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1750-2187-5-10","volume":"5","author":"SK Roy","year":"2010","unstructured":"Roy SK, Srivastava RK, Shankar S (2010) Inhibition of PI3K\/AKT and MAPK\/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 5:10. https:\/\/doi.org\/10.1186\/1750-2187-5-10","journal-title":"J Mol Signal"},{"key":"12021_CR143","doi-asserted-by":"publisher","unstructured":"Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA et al Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation. Cell Metab 2008;8. https:\/\/doi.org\/10.1016\/j.cmet.2008.06.006","DOI":"10.1016\/j.cmet.2008.06.006"},{"key":"12021_CR144","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","volume":"128","author":"J-H Paik","year":"2007","unstructured":"Paik J-H, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z et al (2007) FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis. Cell 128:309\u2013323. https:\/\/doi.org\/10.1016\/j.cell.2006.12.029","journal-title":"Cell"},{"key":"12021_CR145","doi-asserted-by":"publisher","unstructured":"Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F et al Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1\u03b1 interaction. Nature 2003;423. https:\/\/doi.org\/10.1038\/nature01667","DOI":"10.1038\/nature01667"},{"key":"12021_CR146","doi-asserted-by":"publisher","unstructured":"Zhu L, Yang M, Fan L, Yan Q, Zhang L, Mu P et al Interaction between resveratrol and SIRT1: role in neurodegenerative diseases. Naunyn Schmiedebergs Arch Pharmacol 2025;398. https:\/\/doi.org\/10.1007\/s00210-024-03319-w","DOI":"10.1007\/s00210-024-03319-w"},{"key":"12021_CR147","doi-asserted-by":"publisher","first-page":"10812","DOI":"10.1074\/jbc.M113.519355","volume":"289","author":"R Akhter","year":"2014","unstructured":"Akhter R, Sanphui P, Biswas SC (2014) The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in \u03b2-Amyloid-induced Neuron Death. J Biol Chem 289:10812\u201310822. https:\/\/doi.org\/10.1074\/jbc.M113.519355","journal-title":"J Biol Chem"},{"key":"12021_CR148","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tibs.2014.02.003","volume":"39","author":"AE Webb","year":"2014","unstructured":"Webb AE, Brunet A (2014) FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci 39:159\u2013169. https:\/\/doi.org\/10.1016\/j.tibs.2014.02.003","journal-title":"Trends Biochem Sci"},{"key":"12021_CR149","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","volume":"133","author":"E Drummond","year":"2017","unstructured":"Drummond E, Wisniewski T (2017) Alzheimer\u2019s disease: experimental models and reality. Acta Neuropathol 133:155\u2013175. https:\/\/doi.org\/10.1007\/s00401-016-1662-x","journal-title":"Acta Neuropathol"},{"key":"12021_CR150","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.4049\/jimmunol.1501758","volume":"195","author":"MG Thompson","year":"2015","unstructured":"Thompson MG, Larson M, Vidrine A, Barrios K, Navarro F, Meyers K et al (2015) FOXO3\u2013NF-\u03baB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. J Immunol 195:5637\u20135647. https:\/\/doi.org\/10.4049\/jimmunol.1501758","journal-title":"J Immunol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12021-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12021-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12021-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:51:50Z","timestamp":1779803510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12021-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":150,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12021"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12021-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"833"}}