{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:02:29Z","timestamp":1780398149912,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Key Project of Natural Science Foundation of Anhui Provincial University of China","award":["2025AHGXZK31587"],"award-info":[{"award-number":["2025AHGXZK31587"]}]},{"name":"the Graduate Scientific Research Innovation Project of Bengbu Medical University of China","award":["Byycx24004"],"award-info":[{"award-number":["Byycx24004"]}]},{"name":"the Open Project of Anhui Province Key Laboratory of Immunology in Chronic Diseases of China","award":["MBZZ202402"],"award-info":[{"award-number":["MBZZ202402"]}]},{"name":"the Research and Development Project of School-Enterprise Cooperative","award":["AHBYQX-BBMU-2025-1"],"award-info":[{"award-number":["AHBYQX-BBMU-2025-1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12061-w","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:52:20Z","timestamp":1780393940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic analysis of mouse testes with disordered spermatogenesis induced by high-dose BPA exposure during puberty"],"prefix":"10.1007","volume":"53","author":[{"given":"Ke","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinran","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"3","key":"12061_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11259-026-11135-1","volume":"50","author":"NE Emam","year":"2026","unstructured":"Emam NE, Habotta OA, Halawa AA, Abouelmagd MM (2026) L. carnitine modulates oxidative stress, steroidogenic gene disturbance, and testicular histopathology induced by Bisphenol A in male rats. Vet Res Commun 50(3):219","journal-title":"Vet Res Commun"},{"issue":"16","key":"12061_CR2","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.3390\/ijms21165761","volume":"21","author":"I Cimmino","year":"2020","unstructured":"Cimmino I, Fiory F, Perruolo G, Miele C, Beguinot F et al (2020) Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. Int J Mol Sci 21(16):5761","journal-title":"Int J Mol Sci"},{"key":"12061_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","volume":"42","author":"JR Rochester","year":"2013","unstructured":"Rochester JR (2013) Bisphenol A and human health: a review of the literature. Reprod Toxicol 42:132\u2013155","journal-title":"Reprod Toxicol"},{"key":"12061_CR4","doi-asserted-by":"publisher","first-page":"118413","DOI":"10.1016\/j.marpolbul.2025.118413","volume":"220","author":"YH Shen","year":"2025","unstructured":"Shen YH, Chen HN, Liang MY, Guo LG, Gu J et al (2025) Pollution profiles and human health risk assessment of BPA analogues in seafood from a Chinese coastal city. Mar Pollut Bull 220:118413","journal-title":"Mar Pollut Bull"},{"issue":"1","key":"12061_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13293-025-00744-1","volume":"16","author":"P Lertpeerapan","year":"2025","unstructured":"Lertpeerapan P, Kanlayaprasit S, Thongkorn S, Kasitipradit K, Panjabud P et al (2025) Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates and alters splicing in the offspring hippocampus. Biol Sex Differ 16(1):63","journal-title":"Biol Sex Differ"},{"key":"12061_CR6","doi-asserted-by":"publisher","first-page":"106614","DOI":"10.1016\/j.biocel.2024.106614","volume":"173","author":"SA Hyun","year":"2024","unstructured":"Hyun SA, Ka M (2024) Bisphenol A (BPA) and neurological disorders: An overview. Int J Biochem Cell Biol 173:106614","journal-title":"Int J Biochem Cell Biol"},{"key":"12061_CR7","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s41372-024-01925-3","volume":"44","author":"NA Bektas","year":"2024","unstructured":"Bektas NA, Yenigul NN, Pakay K, Dincgez B, Bilgin EY et al (2024) Does Bisphenol-A play a role in the development of neural tube defects? J Perinatol 44:1029\u20131034","journal-title":"J Perinatol"},{"issue":"12","key":"12061_CR8","first-page":"2678","volume":"12","author":"TP Stein","year":"2024","unstructured":"Stein TP (2024) Does Bisphenol A (BPA). Exposure Cause Hum Diseases? Biomedicines 12(12):2678","journal-title":"Exposure Cause Hum Diseases? Biomedicines"},{"key":"12061_CR9","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3390\/jox13040049","volume":"13","author":"JH Kang","year":"2023","unstructured":"Kang JH, Asai D, Toita R (2023) Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases. J Xenobiot 13:775\u2013810","journal-title":"J Xenobiot"},{"key":"12061_CR10","doi-asserted-by":"publisher","first-page":"9810","DOI":"10.1038\/s41598-025-93538-9","volume":"15","author":"W Zhang","year":"2025","unstructured":"Zhang W, Liu J, Wang Y, Wang J, Zhu P et al (2025) Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring. Sci Rep 15:9810","journal-title":"Sci Rep"},{"key":"12061_CR11","doi-asserted-by":"publisher","first-page":"108828","DOI":"10.1016\/j.reprotox.2024.108828","volume":"132","author":"H Batista-Silva","year":"2025","unstructured":"Batista-Silva H, Elie N, Silva F, Delalande C (2025) In vitro bisphenol A impairs testicular energy metabolism and spermatogenesis through nuclear estrogen receptors activation in zebrafish. Reprod Toxicol 132:108828","journal-title":"Reprod Toxicol"},{"key":"12061_CR12","doi-asserted-by":"publisher","first-page":"127880","DOI":"10.1016\/j.chemosphere.2020.127880","volume":"262","author":"X Liu","year":"2021","unstructured":"Liu X, Wang Z, Liu F (2021) Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice. Chemosphere 262:127880","journal-title":"Chemosphere"},{"key":"12061_CR13","doi-asserted-by":"publisher","first-page":"118790","DOI":"10.1016\/j.ecoenv.2025.118790","volume":"303","author":"YJ Park","year":"2025","unstructured":"Park YJ, Hwang SM, Pang WK, Ryu DY, Gedda G, Pang MG (2025) Bisphenol A-induced testicular immune dysfunction leads to suppressed steroidogenesis and excessive histamine production. Ecotoxicol Environ Saf 303:118790","journal-title":"Ecotoxicol Environ Saf"},{"key":"12061_CR14","doi-asserted-by":"publisher","first-page":"125791","DOI":"10.1016\/j.jhazmat.2021.125791","volume":"416","author":"MS Rahman","year":"2021","unstructured":"Rahman MS, Pang WK, Ryu DY, Park YJ, Ryu BY, Pang MG (2021) Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice. J Hazard Mater 416:125791","journal-title":"J Hazard Mater"},{"key":"12061_CR15","doi-asserted-by":"publisher","first-page":"111476","DOI":"10.1016\/j.ecoenv.2020.111476","volume":"208","author":"YJ Park","year":"2021","unstructured":"Park YJ, Pang WK, Ryu DY, Adegoke EO, Rahman MS, Pang MG (2021) Bisphenol A exposure increases epididymal susceptibility to infection in mice. Ecotoxicol Environ Saf 208:111476","journal-title":"Ecotoxicol Environ Saf"},{"key":"12061_CR16","doi-asserted-by":"publisher","first-page":"210307","DOI":"10.5696\/2156-9614-11.29.210307","volume":"11","author":"OA Alabi","year":"2021","unstructured":"Alabi OA, Ologbonjaye KI, Sorungbe AA, Shokunbi OS, Omotunwase OI et al (2021) Bisphenol A-induced Alterations in Different Stages of Spermatogenesis and Systemic Toxicity in Albino Mice (Mus musculus). J Health Pollut 11:210307","journal-title":"J Health Pollut"},{"key":"12061_CR17","doi-asserted-by":"publisher","first-page":"e23862","DOI":"10.1002\/jbt.23862","volume":"38","author":"SK Yadav","year":"2024","unstructured":"Yadav SK, Kumar A, Yadav BG, Bijalwan V, Yadav S et al (2024) Sub-acute bisphenol A exposure induces proteomic alterations and impairs male reproductive health in mice. J Biochem Mol Toxicol 38:e23862","journal-title":"J Biochem Mol Toxicol"},{"key":"12061_CR18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/mrd.23179","volume":"86","author":"K Hu","year":"2019","unstructured":"Hu K, He CF, Ren HH, Wang HY, Liu K et al (2019) LncRNA Gm2044 promotes 17\u03b2-estradiol synthesis in mpGCs by acting as miR-138-5p sponge. Mol Reprod Dev 86:1023\u20131032","journal-title":"Mol Reprod Dev"},{"key":"12061_CR19","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1038\/s41598-025-86392-2","volume":"15","author":"K Kasitipradit","year":"2025","unstructured":"Kasitipradit K, Thongkorn S, Kanlayaprasit S, Saeliw T, Lertpeerapan P et al (2025) Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus. Sci Rep 15:2882","journal-title":"Sci Rep"},{"key":"12061_CR20","doi-asserted-by":"publisher","first-page":"116071","DOI":"10.1016\/j.ecoenv.2024.116071","volume":"272","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Yan C, Xie Q, Wu B, Zhang Y (2024) Exposure to bisphenol A affects transcriptome-wide N6-methyladenine methylation in ovarian granulosa cells. Ecotoxicol Environ Saf 272:116071","journal-title":"Ecotoxicol Environ Saf"},{"key":"12061_CR21","doi-asserted-by":"publisher","first-page":"119034","DOI":"10.1016\/j.envres.2024.119034","volume":"252","author":"HJ Gu","year":"2024","unstructured":"Gu HJ, Kim DY, Shin SH, Rahman MS, Lee HS et al (2024) Genome-wide transcriptome analysis reveals that Bisphenol A activates immune responses in skeletal muscle. Environ Res 252:119034","journal-title":"Environ Res"},{"key":"12061_CR22","doi-asserted-by":"publisher","first-page":"112449","DOI":"10.1016\/j.biopha.2021.112449","volume":"145","author":"N Zhang","year":"2022","unstructured":"Zhang N, Wang Y, Chen Z, Ren J, Rehman A et al (2022) Single-cell transcriptome analysis of Bisphenol A exposure reveals the key roles of the testicular microenvironment in male reproduction. Biomed pharmacotherapy = Biomedecine pharmacotherapie 145:112449","journal-title":"Biomed pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"12061_CR23","doi-asserted-by":"crossref","unstructured":"Matteo G, Rowan-Carroll A, Bradford LM, Meier MJ, Williams A et al (2026) Transcriptomic analysis of BPA alternative chemicals in primary human mammary epithelial cells. Toxicology 521:154375","DOI":"10.1016\/j.tox.2025.154375"},{"key":"12061_CR24","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.cgh.2026.01.007","volume":"24","author":"AM Buchner","year":"2026","unstructured":"Buchner AM, Huang RJ, Lauwers GY, El-Serag HB (2026) AGA Clinical Practice Update on Management of Gastric Polyps: Expert Review. Clin Gastroenterol H 24:893\u2013905","journal-title":"Clin Gastroenterol H"},{"key":"12061_CR25","doi-asserted-by":"publisher","first-page":"138937","DOI":"10.1016\/j.jhazmat.2025.138937","volume":"495","author":"Y Yang","year":"2025","unstructured":"Yang Y, Wu D, Lei T, Zhao HY, Yu JJ et al (2025) Bisphenol A caused abnormal spermatogenesis of Eriocheir sinensis through es-ERR\/es-KIF4A pathway with discussion of BPA substitutes. J Hazard Mater 495:138937","journal-title":"J Hazard Mater"},{"key":"12061_CR26","doi-asserted-by":"publisher","first-page":"deaf097313","DOI":"10.1093\/humrep\/deaf097.313","volume":"40","author":"R Akhigbe","year":"2025","unstructured":"Akhigbe R, Akhigbe T (2025) Silymarin attenuates BPA-induced testicular endocrine and spermatogenesis disruption by inhibiting testicular iron accumulation and amyloidosis via the modulation of Nrf2\/HO-1 and TLR4\/NF-kB signaling. Hum Reprod 40:deaf097313","journal-title":"Hum Reprod"},{"key":"12061_CR27","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/jat.4417","volume":"43","author":"Y Ling","year":"2023","unstructured":"Ling Y, Huang X, Li A, Zhang J, Chen J et al (2023) Bisphenol A exposure induces testicular oxidative damage via FTO\/m6A\/Nrf2 axis during postnatal development in mice. J Appl Toxicol 43:694\u2013705","journal-title":"J Appl Toxicol"},{"key":"12061_CR28","doi-asserted-by":"publisher","first-page":"107617","DOI":"10.1016\/j.envint.2022.107617","volume":"170","author":"DY Ryu","year":"2022","unstructured":"Ryu DY, Pang WK, Adegoke EO, Rahman MS, Park YJ, Pang MG (2022) Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially. Environ Int 170:107617","journal-title":"Environ Int"},{"key":"12061_CR29","doi-asserted-by":"publisher","first-page":"119067","DOI":"10.1016\/j.envpol.2022.119067","volume":"302","author":"EO Adegoke","year":"2022","unstructured":"Adegoke EO, Rahman MS, Amjad S, Pang WK, Ryu DY et al (2022) Bisphenol A damages testicular junctional proteins transgenerationally in mice. Environ Pollut 302:119067","journal-title":"Environ Pollut"},{"key":"12061_CR30","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1007\/s10068-024-01564-6","volume":"33","author":"B Zhou","year":"2024","unstructured":"Zhou B, Niu Y, Wang D, Liu L, Guo J (2024) Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3\/caspase-1 pathway and gut microbiota in mice model. Food Sci Biotechnol 33:3119\u20133130","journal-title":"Food Sci Biotechnol"},{"key":"12061_CR31","doi-asserted-by":"publisher","first-page":"116804","DOI":"10.1016\/j.ecoenv.2024.116804","volume":"283","author":"J Yang","year":"2024","unstructured":"Yang J, Qin S, Sun N, Cai Y, Li J et al (2024) Neohesperidin alleviates the inhibitory effect of bisphenol A on the myogenic differentiation of umbilical cord mesenchymal stem cells via the IGF1R\/AKT1\/RHOA signaling pathway. Ecotoxicol Environ Saf 283:116804","journal-title":"Ecotoxicol Environ Saf"},{"key":"12061_CR32","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1111\/1750-3841.17103","volume":"89","author":"L Wang","year":"2024","unstructured":"Wang L, Zhuang J, Xue Z, Lu H, Zeng W, Zhang T (2024) VD(3)\/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy. J Food Sci 89:3858\u20133870","journal-title":"J Food Sci"},{"key":"12061_CR33","doi-asserted-by":"publisher","first-page":"114908","DOI":"10.1016\/j.fct.2024.114908","volume":"192","author":"F Pan","year":"2024","unstructured":"Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L (2024) Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway. Food Chem Toxicol 192:114908","journal-title":"Food Chem Toxicol"},{"key":"12061_CR34","doi-asserted-by":"publisher","first-page":"8043","DOI":"10.1038\/s41598-024-58545-2","volume":"14","author":"O Banerjee","year":"2024","unstructured":"Banerjee O, Singh S, Paul T, Maji BK, Mukherjee S (2024) Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets. Sci Rep 14:8043","journal-title":"Sci Rep"},{"key":"12061_CR35","first-page":"443","volume":"8","author":"DR Cohen","year":"1993","unstructured":"Cohen DR, Vandermark SE, McGovern JD, Bradley MP (1993) Transcriptional regulation in the testis: a role for transcription factor AP-1 complexes at various stages of spermatogenesis. Oncogene 8:443\u2013455","journal-title":"Oncogene"},{"key":"12061_CR36","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1126\/science.2475907","volume":"245","author":"H Wolfes","year":"1989","unstructured":"Wolfes H, Kogawa K, Millette CF, Cooper GM (1989) Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis. Science 245:740\u2013743","journal-title":"Science"},{"key":"12061_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/gcen.1995.1093","volume":"99","author":"P Chieffi","year":"1995","unstructured":"Chieffi P, Minucci S, Cobellis G, Fasano S, Pierantoni R (1995) Changes in proto-oncogene activity in the testis of the frog, Rana esculenta, during the annual reproductive cycle. Gen Comp Endocrinol 99:127\u2013136","journal-title":"Gen Comp Endocrinol"},{"key":"12061_CR38","doi-asserted-by":"publisher","first-page":"106135","DOI":"10.1016\/j.jsbmb.2022.106135","volume":"223","author":"Q Wang","year":"2022","unstructured":"Wang Q, Yan Q, Nan J, Wang J, Zhang Y, Zhao X (2022) Syce1 and Syce3 regulate testosterone and dihydrotestosterone synthesis via steroidogenic pathways in mouse Sertoli and Leydig cells. J Steroid Biochem Mol Biol 223:106135","journal-title":"J Steroid Biochem Mol Biol"},{"key":"12061_CR39","first-page":"380","volume":"10","author":"MS Mahendroo","year":"1996","unstructured":"Mahendroo MS, Cala KM, Russell DW (1996) 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol 10:380\u2013392","journal-title":"Mol Endocrinol"},{"key":"12061_CR40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1615\/CritRevEukarGeneExpr.v5.i2.30","volume":"5","author":"AK Roy","year":"1995","unstructured":"Roy AK, Chatterjee B (1995) Androgen action. Crit Rev Eukaryot Gene Expr 5:157\u2013176","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"12061_CR41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jsbmb.2012.11.019","volume":"135","author":"VL Simoes","year":"2013","unstructured":"Simoes VL, Alves MG, Martins AD, Dias TR, Rato L et al (2013) Regulation of apoptotic signaling pathways by 5alpha-dihydrotestosterone and 17beta-estradiol in immature rat Sertoli cells. J Steroid Biochem Mol Biol 135:15\u201323","journal-title":"J Steroid Biochem Mol Biol"},{"key":"12061_CR42","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1210\/endo-129-3-1489","volume":"129","author":"A Janecki","year":"1991","unstructured":"Janecki A, Jakubowiak A, Steinberger A (1991) Regulation of transepithelial electrical resistance in two-compartment Sertoli cell cultures: in vitro model of the blood-testis barrier. Endocrinology 129:1489\u20131496","journal-title":"Endocrinology"},{"issue":"Suppl 2","key":"12061_CR43","first-page":"56","volume":"47","author":"C Desjardins","year":"1978","unstructured":"Desjardins C (1978) Endocrine regulation of reproductive development and function in the male. J Anim Sci 47(Suppl 2):56\u201379","journal-title":"J Anim Sci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12061-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12061-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12061-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:03:40Z","timestamp":1780394620000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12061-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12061"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12061-w","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"7 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Laboratory Animal Management Ethics Committee of Bengbu Medical University of China (Approval No.: 2023180) and conducted in compliance with the Regulations on the Administration of Laboratory Animals (revised March 1, 2017) issued by the State Council of the People\u2019s Republic of China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"875"}}