{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:59:09Z","timestamp":1780743549991,"version":"3.54.1"},"reference-count":133,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12073-6","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:12:13Z","timestamp":1780733533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory and antimicrobial actions of extracellular vesicles in vaginal infections: implications for female infertility"],"prefix":"10.1007","volume":"53","author":[{"given":"Parya","family":"Mahdavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mazinani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafid Jihad","family":"Albadr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Sarrafzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waam Mohammed","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Alwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood Jasem","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Ghadery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Jamalpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"issue":"4","key":"12073_CR1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1177\/08980101241275201","volume":"43","author":"M Abdullahzadeh","year":"2025","unstructured":"Abdullahzadeh M et al (2025) A grounded theory approach to understanding men confronting infertility. J Holist Nurs 43(4):322\u2013335","journal-title":"J Holist Nurs"},{"key":"12073_CR2","doi-asserted-by":"publisher","first-page":"105980","DOI":"10.1016\/j.micpath.2023.105980","volume":"175","author":"O Gholizadeh","year":"2023","unstructured":"Gholizadeh O et al (2023) Review of the evidence of the effects of human papillomavirus infection and Gardnerella vaginalis, and their co-infection on infertility. Microb Pathog 175:105980","journal-title":"Microb Pathog"},{"issue":"6","key":"12073_CR3","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/humupd\/dmad019","volume":"29","author":"AD Pathare","year":"2023","unstructured":"Pathare AD et al (2023) Endometrial receptivity in women of advanced age: an underrated factor in infertility. Hum Reprod Update 29(6):773\u2013793","journal-title":"Hum Reprod Update"},{"issue":"3","key":"12073_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/amh70030033","volume":"70","author":"S Occhipinti","year":"2025","unstructured":"Occhipinti S et al (2025) The Impact of Genital Infections on Women\u2019s Fertility. Acta Microbiol Hellenica 70(3):33","journal-title":"Acta Microbiol Hellenica"},{"issue":"3","key":"12073_CR5","first-page":"139","volume":"19","author":"TD Olimjonovna","year":"2025","unstructured":"Olimjonovna TD (2025) BACTERIAL VAGINOSIS IS A DANGEROUS DISEASE. Mod Educ Dev 19(3):139\u2013151","journal-title":"Mod Educ Dev"},{"key":"12073_CR6","first-page":"1060","volume":"3","author":"M Moradialvand","year":"2024","unstructured":"Moradialvand M, Hoori M, Hoori R (2024) Drug Delivery Platforms for Vaginal Infection: Biological Barriers, Microbe-Associated Infections, and Delivery. Mater Chem Horiz 3:1060","journal-title":"Mater Chem Horiz"},{"key":"12073_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2174\/9789815313628125010009","volume-title":"Antibiotics and Reproductive Health","author":"A Benabbou","year":"2025","unstructured":"Benabbou A, Malik J, Perveen S (2025) Common Reproductive Infections and their Treatments. Antibiotics and Reproductive Health. Bentham Science Publishers, pp 167\u2013181"},{"key":"12073_CR8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae295","author":"K Htaik","year":"2024","unstructured":"Htaik K et al (2024) Systematic review and meta-analysis of the association between Mycoplasma genitalium and pelvic inflammatory disease (PID). Clin Infect Dis. https:\/\/doi.org\/10.1093\/cid\/ciae295","journal-title":"Clin Infect Dis"},{"key":"12073_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/22840265251350207","author":"S Rana","year":"2025","unstructured":"Rana S et al (2025) The silent threat: pelvic inflammatory disease and long-term health outcomes with management. J Endometr Pelvic Pain Disord. https:\/\/doi.org\/10.1177\/22840265251350207","journal-title":"J Endometr Pelvic Pain Disord"},{"issue":"1","key":"12073_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/tbed\/1051460","volume":"2025","author":"A Jaromin","year":"2025","unstructured":"Jaromin A et al (2025) Recent advances and challenges in the development and delivery of antiprotozoal agents against trichomoniasis. Transbound Emerg Dis 2025(1):1051460","journal-title":"Transbound Emerg Dis"},{"issue":"9","key":"12073_CR11","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3390\/jof11090632","volume":"11","author":"N Srb","year":"2025","unstructured":"Srb N et al (2025) A Comprehensive Overview of Candida albicans as the Leading Pathogen in Vulvovaginal Candidiasis. J fungi 11(9):632","journal-title":"J fungi"},{"issue":"17","key":"12073_CR12","doi-asserted-by":"publisher","first-page":"8216","DOI":"10.1039\/D3NR05524H","volume":"16","author":"KA Moore","year":"2024","unstructured":"Moore KA, Petersen AP, Zierden HC (2024) Microorganism-derived extracellular vesicles: emerging contributors to female reproductive health. Nanoscale 16(17):8216\u20138235","journal-title":"Nanoscale"},{"issue":"1","key":"12073_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12672-025-01829-4","volume":"16","author":"U Sharma","year":"2025","unstructured":"Sharma U et al (2025) The heat of the battle: inflammation\u2019s role in prostate cancer development and inflammation-targeted therapies. Discover Oncol 16(1):108","journal-title":"Discover Oncol"},{"issue":"2","key":"12073_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/biology14020198","volume":"14","author":"NH Dlamini","year":"2025","unstructured":"Dlamini NH et al (2025) Unlocking Gamete Quality Through Extracellular Vesicles: Emerging Perspectives. Biology 14(2):198","journal-title":"Biology"},{"issue":"4","key":"12073_CR15","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1021\/acsnano.3c10884","volume":"18","author":"H Liu","year":"2024","unstructured":"Liu H et al (2024) Mesenchymal stem cell derived exosomes repair uterine injury by targeting transforming growth factor-\u03b2 signaling. ACS Nano 18(4):3509\u20133519","journal-title":"ACS Nano"},{"key":"12073_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-024-00814-1","author":"X Yang","year":"2024","unstructured":"Yang X et al (2024) Hypoxic preconditioned ADSC exosomes enhance vaginal wound healing via accelerated keratinocyte proliferation and migration through AKT\/HIF\u20111\u03b1 axis activation. Cell Mol Bioeng. https:\/\/doi.org\/10.1007\/s12195-024-00814-1","journal-title":"Cell Mol Bioeng"},{"issue":"5","key":"12073_CR17","first-page":"27","volume":"24","author":"S Teymouri","year":"2024","unstructured":"Teymouri S, Pourhajibagher M, Bahador A (2024) Exosomes: friends or foes in microbial infections? Infect Disord 24(5):27\u201344","journal-title":"Infect Disord"},{"key":"12073_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2024.104283","author":"RO Saleh","year":"2024","unstructured":"Saleh RO et al (2024) An updated study of the relationship between bacterial infections and women\u2019s immune system, focusing on bacterial compositions with successful pregnancy. J Reprod Immunol. https:\/\/doi.org\/10.1016\/j.jri.2024.104283","journal-title":"J Reprod Immunol"},{"key":"12073_CR19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fmicb.2011.00107","volume":"2","author":"AE Jerse","year":"2011","unstructured":"Jerse AE et al (2011) Estradiol-treated female mice as surrogate hosts for Neisseria gonorrhoeae genital tract infections. Front Microbiol 2:107","journal-title":"Front Microbiol"},{"issue":"11","key":"12073_CR20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/OLQ.0000000000001066","volume":"46","author":"SE Brown","year":"2019","unstructured":"Brown SE et al (2019) The vaginal microbiota and behavioral factors associated with genital Candida albicans detection in reproductive-age women. Sex Transm Dis 46(11):753\u2013758","journal-title":"Sex Transm Dis"},{"key":"12073_CR21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fcimb.2020.00168","volume":"10","author":"S Morrill","year":"2020","unstructured":"Morrill S, Gilbert NM, Lewis AL (2020) Gardnerella vaginalis as a cause of bacterial vaginosis: appraisal of the evidence from in vivo models. Front Cell Infect Microbiol 10:168","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"12073_CR22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ajog.2020.10.019","volume":"224","author":"J Ravel","year":"2021","unstructured":"Ravel J, Moreno I, Sim\u00f3n C (2021) Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol 224(3):251\u2013257","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"12073_CR23","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s12192-010-0171-4","volume":"15","author":"IM Linhares","year":"2010","unstructured":"Linhares IM, Witkin SS (2010) Immunopathogenic consequences of Chlamydia trachomatis 60\u00a0kDa heat shock protein expression in the female reproductive tract. Cell Stress Chaperones 15(5):467\u2013473","journal-title":"Cell Stress Chaperones"},{"key":"12073_CR24","unstructured":"Khamees SS (2012) Characterization of vaginal discharge among women complaining of genital tract infection. Int J Pharm life Sci, 3(10)"},{"issue":"1","key":"12073_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.33545\/26649004.2025.v7.i1a.40","volume":"7","author":"MH FA","year":"2025","unstructured":"FA MH, GA AE (2025) Influence of pelvic inflammatory disease on fertility in Zliten, Libya. Int J Gynaecol Obstet 7(1):52\u201360","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"12073_CR26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3126\/jbs.v10i1.56077","volume":"10","author":"SR Ahmad","year":"2023","unstructured":"Ahmad SR, Ghosh P (2023) An analysis of the Vaginal microbiome and the impact of infections on female infertility, Cervical Intraepithelial Neoplasia (CIN), and Cervical cancer. J Biomedical Therapeutic Sci 10(1):11\u201318","journal-title":"J Biomedical Therapeutic Sci"},{"issue":"3","key":"12073_CR27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3904\/kjim.2024.213","volume":"40","author":"M-H Kim","year":"2025","unstructured":"Kim M-H et al (2025) Clinical approach to sexually transmitted infections and pelvic inflammatory disease in women with acute pyelonephritis. Korean J Intern Med 40(3):482","journal-title":"Korean J Intern Med"},{"issue":"3","key":"12073_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ajog.2019.09.002","volume":"222","author":"DE Soper","year":"2020","unstructured":"Soper DE (2020) Bacterial vaginosis and surgical site infections. Am J Obstet Gynecol 222(3):219\u2013223","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"12073_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12934-020-01464-4","volume":"19","author":"WJY Chee","year":"2020","unstructured":"Chee WJY, Chew SY, Than LTL (2020) Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact 19(1):203","journal-title":"Microb Cell Fact"},{"key":"12073_CR30","first-page":"153","volume":"3","author":"II Kutsenko","year":"2024","unstructured":"Kutsenko II et al (2024) The changes in the landscape of the vaginal microbiome in patients undergoing complex treatment for mixed recurrent vaginal infections. Obstet Gynecol 3:153\u2013162","journal-title":"Obstet Gynecol"},{"issue":"2","key":"12073_CR31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.idc.2023.02.001","volume":"37","author":"OT Van Gerwen","year":"2023","unstructured":"Van Gerwen OT et al (2023) Trichomoniasis Infect Dis Clin North Am 37(2):245\u2013265","journal-title":"Trichomoniasis Infect Dis Clin North Am"},{"issue":"1","key":"12073_CR32","doi-asserted-by":"publisher","first-page":"84","DOI":"10.56183\/iberojhr.v4i1.619","volume":"4","author":"BA Mathias","year":"2024","unstructured":"Mathias BA et al (2024) Side effects of Sexually Transmitted Infections (STIs) on female fertility: diagnostic and treatment strategies\u2013a literature review. Ibero-American J Health Sci Res 4(1):84\u201392","journal-title":"Ibero-American J Health Sci Res"},{"key":"12073_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-015-1055-0","volume":"15","author":"P Kissinger","year":"2015","unstructured":"Kissinger P (2015) Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. BMC Infect Dis 15:1\u20138","journal-title":"BMC Infect Dis"},{"issue":"2","key":"12073_CR34","doi-asserted-by":"publisher","first-page":"338","DOI":"10.4314\/njpar.v45i2.10","volume":"45","author":"U Jabr","year":"2024","unstructured":"Jabr U, Alsaady H, Aziz Z (2024) The Effect of Trichomonas vaginalis and some Urogenital Bacteria on Male Fertility in Maysan Province, Iraq. Nigerian J Parasitol 45(2):338\u2013349","journal-title":"Nigerian J Parasitol"},{"key":"12073_CR35","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s11884-020-00606-z","volume":"15","author":"M Blaganje","year":"2020","unstructured":"Blaganje M, Barbi\u010d M (2020) Vaginal Yeast Infection. Curr Bladder Dysfunct Rep 15:325\u2013331","journal-title":"Curr Bladder Dysfunct Rep"},{"issue":"6","key":"12073_CR36","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3390\/antibiotics10060719","volume":"10","author":"RJ Joseph","year":"2021","unstructured":"Joseph RJ et al (2021) Finding a balance in the vaginal microbiome: how do we treat and prevent the occurrence of bacterial vaginosis? Antibiotics 10(6):719","journal-title":"Antibiotics"},{"key":"12073_CR37","doi-asserted-by":"crossref","unstructured":"Wang Y, Liu Z, Chen T (2024) Vaginal microbiota: Potential targets for vulvovaginal candidiasis infection. Heliyon","DOI":"10.2139\/ssrn.4660638"},{"issue":"5","key":"12073_CR38","doi-asserted-by":"publisher","first-page":"02611","DOI":"10.1128\/aac","volume":"63","author":"E Larkin","year":"2019","unstructured":"Larkin E et al (2019) A novel 1, 3-beta-d-glucan inhibitor, ibrexafungerp (formerly SCY-078), shows potent activity in the lower pH environment of vulvovaginitis. Antimicrob Agents Chemother 63(5):02611\u201302618. https:\/\/doi.org\/10.1128\/aac","journal-title":"Antimicrob Agents Chemother"},{"key":"12073_CR39","doi-asserted-by":"crossref","unstructured":"Cooke G et al (2022) Treatment for recurrent vulvovaginal candidiasis (thrush). Cochrane Database Syst Reviews, (1)","DOI":"10.1002\/14651858.CD009151.pub2"},{"key":"12073_CR40","doi-asserted-by":"crossref","unstructured":"Avitabile E, Menotti L (2024) Protective Mech Vaginal Lactobacilli against Sexually Transmitted Viral Infections 25(17)","DOI":"10.3390\/ijms25179168"},{"key":"12073_CR41","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s13669-015-0134-y","volume":"4","author":"M Stanley","year":"2015","unstructured":"Stanley M (2015) Immunology of HPV Infection. Curr Obstet Gynecol Rep 4:195\u2013200","journal-title":"Curr Obstet Gynecol Rep"},{"issue":"9","key":"12073_CR42","doi-asserted-by":"publisher","first-page":"e1012477","DOI":"10.1371\/journal.ppat.1012477","volume":"20","author":"K Wang","year":"2024","unstructured":"Wang K et al (2024) A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion. PLoS Pathog 20(9):e1012477","journal-title":"PLoS Pathog"},{"key":"12073_CR43","doi-asserted-by":"publisher","first-page":"1036869","DOI":"10.3389\/fcimb.2022.1036869","volume":"12","author":"M Zeng","year":"2023","unstructured":"Zeng M et al (2023) Roles of vaginal flora in human papillomavirus infection, virus persistence and clearance. Front Cell Infect Microbiol 12:1036869","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"12073_CR44","first-page":"188","volume":"24","author":"PH Pebdeni","year":"2023","unstructured":"Pebdeni PH et al (2023) Increased Risk of Infertility in Women Infected with Human Papillomavirus. J Reprod Infertil 24(3):188\u2013197","journal-title":"J Reprod Infertil"},{"issue":"5","key":"12073_CR45","doi-asserted-by":"publisher","first-page":"6","DOI":"10.18565\/pharmateca.2024.5.6-15","volume":"31","author":"A Khryanin","year":"2024","unstructured":"Khryanin A, Sturov V (2024) Herpes virus infection and reproductive health disorders in women. Analytical review. Pharmateca 31(5):6\u201315","journal-title":"Pharmateca"},{"key":"12073_CR46","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae166","author":"NH van Teijlingen","year":"2024","unstructured":"van Teijlingen NH et al (2024) Prevotella timonensis bacteria associated with vaginal dysbiosis enhance Human Immunodeficiency Virus type 1 susceptibility of vaginal CD4\u2009+\u2009T cells. J Infect Dis. https:\/\/doi.org\/10.1093\/infdis\/jiae166","journal-title":"J Infect Dis"},{"issue":"5","key":"12073_CR47","doi-asserted-by":"publisher","first-page":"e23500","DOI":"10.1096\/fj.202301519RR","volume":"38","author":"C Cong","year":"2024","unstructured":"Cong C et al (2024) Infectious hepatitis E virus excreted into the vagina. FASEB J 38(5):e23500","journal-title":"FASEB J"},{"issue":"1","key":"12073_CR48","doi-asserted-by":"publisher","first-page":"27066","DOI":"10.3402\/jev.v4.27066","volume":"4","author":"M Y\u00e1\u00f1ez-M\u00f3","year":"2015","unstructured":"Y\u00e1\u00f1ez-M\u00f3 M et al (2015) Biological properties of extracellular vesicles and their physiological functions. J Extracell vesicles 4(1):27066","journal-title":"J Extracell vesicles"},{"issue":"9","key":"12073_CR49","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/ki.2012.256","volume":"82","author":"ML Alvarez","year":"2012","unstructured":"Alvarez ML et al (2012) Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers. Kidney Int 82(9):1024\u20131032","journal-title":"Kidney Int"},{"key":"12073_CR50","first-page":"639","volume":"4","author":"RB Valjee","year":"2023","unstructured":"Valjee RB et al (2023) Circulating exosomes in sepsis: A potential role as diagnostic biomarkers, therapeutic and drug delivery carriers. Smart Mater Med 4:639\u2013647","journal-title":"Smart Mater Med"},{"key":"12073_CR51","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jconrel.2018.09.030","volume":"290","author":"E Schulz","year":"2018","unstructured":"Schulz E et al (2018) Biocompatible bacteria-derived vesicles show inherent antimicrobial activity. J Controlled Release 290:46\u201355","journal-title":"J Controlled Release"},{"issue":"4","key":"12073_CR52","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200(4):373\u2013383","journal-title":"J Cell Biol"},{"issue":"4","key":"12073_CR53","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"G Van Niel","year":"2018","unstructured":"Van Niel G, d\u2019Angelo G, Raposo G (2018) Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 19(4):213\u2013228","journal-title":"Nat Rev Mol Cell Biol"},{"key":"12073_CR54","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10571-016-0366-z","volume":"36","author":"ER Abels","year":"2016","unstructured":"Abels ER, Breakefield XO (2016) Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake. Cell Mol Neurobiol 36:301\u2013312","journal-title":"Cell Mol Neurobiol"},{"key":"12073_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.12.003","author":"TL Whiteside","year":"2018","unstructured":"Whiteside TL (2018) Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Semin Immunol. https:\/\/doi.org\/10.1016\/j.smim.2017.12.003","journal-title":"Semin Immunol"},{"issue":"7","key":"12073_CR56","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s00216-022-04174-5","volume":"415","author":"TS Martins","year":"2023","unstructured":"Martins TS, Vaz M, Henriques AG (2023) A review on comparative studies addressing exosome isolation methods from body fluids. Anal Bioanal Chem 415(7):1239\u20131263","journal-title":"Anal Bioanal Chem"},{"key":"12073_CR57","doi-asserted-by":"crossref","unstructured":"Jeong G-J et al (2024) Bacterial extracellular vesicles: modulation of biofilm formation and virulence. Acta Biomater","DOI":"10.1016\/j.actbio.2024.02.029"},{"key":"12073_CR58","doi-asserted-by":"crossref","unstructured":"Li Y et al (2024) Exosome-decorated Bio-heterojunctions Reduce Heat and ROS Transfer Distance for Boosted Antibacterial and Tumor Therapy. Biomaterials, : p. 122921","DOI":"10.1016\/j.biomaterials.2024.122921"},{"key":"12073_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22606","author":"S Gurunathan","year":"2023","unstructured":"Gurunathan S et al (2023) Antibacterial and antibiofilm effects of Pseudomonas aeruginosa derived outer membrane vesicles against Streptococcus mutans. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22606","journal-title":"Heliyon"},{"issue":"1","key":"12073_CR60","doi-asserted-by":"publisher","first-page":"25465","DOI":"10.3402\/jev.v3.25465","volume":"3","author":"\u00c1M L\u0151rincz","year":"2014","unstructured":"L\u0151rincz \u00c1M et al (2014) Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes. J Extracell vesicles 3(1):25465","journal-title":"J Extracell vesicles"},{"key":"12073_CR61","doi-asserted-by":"crossref","unstructured":"Kim T et al (2024) Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy. medRxiv, : p. 2024.04. 03.24304152","DOI":"10.1101\/2024.04.03.24304152"},{"issue":"21","key":"12073_CR62","doi-asserted-by":"publisher","first-page":"7018","DOI":"10.1039\/D3BM01103H","volume":"11","author":"S Zhang","year":"2023","unstructured":"Zhang S et al (2023) Microneedle systems: cell, exosome, and nucleic acid based strategies. Biomaterials Sci 11(21):7018\u20137033","journal-title":"Biomaterials Sci"},{"key":"12073_CR63","doi-asserted-by":"publisher","first-page":"139034","DOI":"10.1016\/j.foodchem.2024.139034","volume":"447","author":"Q Xu","year":"2024","unstructured":"Xu Q et al (2024) Enhanced antibacterial activity of bovine milk exosome-based drug formulation against bacterial pathogens. Food Chem 447:139034","journal-title":"Food Chem"},{"key":"12073_CR64","doi-asserted-by":"publisher","first-page":"106607","DOI":"10.1016\/j.jddst.2025.106607","volume":"105","author":"Y Lee","year":"2025","unstructured":"Lee Y, Cho H, Kim K-s (2025) Antibiotic-loaded Lactobacillus-derived extracellular vesicles enhance the bactericidal efficacy against Staphylococcus species. J Drug Deliv Sci Technol 105:106607","journal-title":"J Drug Deliv Sci Technol"},{"key":"12073_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.126067","author":"X Chunxing","year":"2025","unstructured":"Chunxing X et al (2025) The inhibitory effect of extracellular vesicles derived from S. epidermidis on MRSA biofilms. Int J Pharm. https:\/\/doi.org\/10.1016\/j.ijpharm.2025.126067","journal-title":"Int J Pharm"},{"key":"12073_CR66","doi-asserted-by":"publisher","DOI":"10.1088\/2632-959X\/ad9299","author":"C Zhu","year":"2024","unstructured":"Zhu C, Gao B, Li J (2024) Zingiber officinale-derived exosome-like nanoparticles as antimicrobial agents via lipid-mediated inhibition. Nano Express. https:\/\/doi.org\/10.1088\/2632-959X\/ad9299","journal-title":"Nano Express"},{"issue":"3","key":"12073_CR67","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1021\/acsabm.3c01256","volume":"7","author":"S Zhou","year":"2024","unstructured":"Zhou S et al (2024) Garlic-derived exosome-like nanovesicles-based wound dressing for Staphylococcus aureus infection visualization and treatment. ACS Appl Bio Mater 7(3):1888\u20131898","journal-title":"ACS Appl Bio Mater"},{"key":"12073_CR68","doi-asserted-by":"crossref","unstructured":"Peng Z et al (2025) Characterization of extracellular vesicles released from Prochlorococcus MED4 at the steady state and under a light\u2013dark cycle. Philosophical Transactions of the Royal Society B: Biological Sciences, 380(1918)","DOI":"10.1098\/rstb.2023.0339"},{"issue":"7","key":"12073_CR69","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3390\/diagnostics16071044","volume":"16","author":"OF Adebayo","year":"2026","unstructured":"Adebayo OF et al (2026) Clinical Utility of Small Extracellular Vesicles as Liquid Biopsy for Oral Mucosal Disease Diagnostics: Emerging Perspectives. Diagnostics 16(7):1044","journal-title":"Diagnostics"},{"issue":"1","key":"12073_CR70","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41522-024-00502-y","volume":"10","author":"A Joseph","year":"2024","unstructured":"Joseph A et al (2024) Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways. npj Biofilms Microbiomes 10(1):28","journal-title":"npj Biofilms Microbiomes"},{"key":"12073_CR71","doi-asserted-by":"publisher","unstructured":"Mehta SD et al (2020) Host genetic factors associated with vaginal microbiome composition in Kenyan women. Msystems 5(4). https:\/\/doi.org\/10.1128\/msystems 00502\u2009\u2013\u200920","DOI":"10.1128\/msystems"},{"key":"12073_CR72","unstructured":"Model HP (2021) The Role of Small Extracellular Vesicles in Viral-Protozoan Symbiosis: Lessons From. Extracellular Vesicles in Infectious Diseases"},{"issue":"6","key":"12073_CR73","doi-asserted-by":"publisher","first-page":"e12426","DOI":"10.1111\/pim.12426","volume":"39","author":"L Olmos-Ortiz","year":"2017","unstructured":"Olmos-Ortiz L et al (2017) Trichomonas vaginalis exosome\u2010like vesicles modify the cytokine profile and reduce inflammation in parasite\u2010infected mice. Parasite Immunol 39(6):e12426","journal-title":"Parasite Immunol"},{"issue":"4","key":"12073_CR74","doi-asserted-by":"publisher","first-page":"e4029","DOI":"10.1002\/cbf.4029","volume":"42","author":"MY Alshahrani","year":"2024","unstructured":"Alshahrani MY et al (2024) A comprehensive insight into the immunomodulatory role of MSCs-derived exosomes (MSC\u2010Exos) through modulating pattern\u2010recognition receptors (PRRs). Cell Biochem Funct 42(4):e4029","journal-title":"Cell Biochem Funct"},{"key":"12073_CR75","doi-asserted-by":"publisher","first-page":"659621","DOI":"10.3389\/fimmu.2021.659621","volume":"12","author":"Q Zheng","year":"2021","unstructured":"Zheng Q et al (2021) The unique immunomodulatory properties of MSC-derived exosomes in organ transplantation. Front Immunol 12:659621","journal-title":"Front Immunol"},{"key":"12073_CR76","doi-asserted-by":"publisher","first-page":"1131701","DOI":"10.3389\/fphys.2023.1131701","volume":"14","author":"C Zhang","year":"2023","unstructured":"Zhang C et al (2023) Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1\u2013to\u2013M2 transformation. Front Physiol 14:1131701","journal-title":"Front Physiol"},{"key":"12073_CR77","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.actbio.2020.06.029","volume":"113","author":"L Xin","year":"2020","unstructured":"Xin L et al (2020) A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomater 113:252\u2013266","journal-title":"Acta Biomater"},{"issue":"2","key":"12073_CR78","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s10142-024-01303-4","volume":"24","author":"Y Chen","year":"2024","unstructured":"Chen Y et al (2024) Unveiling the protective effects of BMSCs\/anti-miR-124-3p exosomes on LPS-induced endometrial injury. Funct Integr Genom 24(2):32","journal-title":"Funct Integr Genom"},{"issue":"9","key":"12073_CR79","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/stem.3204","volume":"38","author":"C Ding","year":"2020","unstructured":"Ding C et al (2020) Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7. Stem Cells 38(9):1137\u20131148","journal-title":"Stem Cells"},{"key":"12073_CR80","doi-asserted-by":"publisher","first-page":"786111","DOI":"10.3389\/fmicb.2021.786111","volume":"12","author":"S Keshtkar","year":"2022","unstructured":"Keshtkar S et al (2022) Stem cell-derived exosome as potential therapeutics for microbial diseases. Front Microbiol 12:786111","journal-title":"Front Microbiol"},{"issue":"11","key":"12073_CR81","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/jof9111078","volume":"9","author":"J Karkowska-Kuleta","year":"2023","unstructured":"Karkowska-Kuleta J et al (2023) Candida albicans Biofilm-Derived Extracellular Vesicles Are Involved in the Tolerance to Caspofungin, Biofilm Detachment, and Fungal Proteolytic Activity. J Fungi 9(11):1078","journal-title":"J Fungi"},{"key":"12073_CR82","doi-asserted-by":"publisher","first-page":"103666","DOI":"10.1016\/j.micpath.2019.103666","volume":"136","author":"K Kone\u010dn\u00e1","year":"2019","unstructured":"Kone\u010dn\u00e1 K et al (2019) A comparative analysis of protein virulence factors released via extracellular vesicles in two Candida albicans strains cultivated in a nutrient-limited medium. Microb Pathog 136:103666","journal-title":"Microb Pathog"},{"key":"12073_CR83","doi-asserted-by":"publisher","first-page":"777613","DOI":"10.3389\/fimmu.2022.777613","volume":"13","author":"M Zhao","year":"2022","unstructured":"Zhao M et al (2022) Antimicrobial effect of extracellular vesicles derived from human oral mucosal epithelial cells on candida albicans. Front Immunol 13:777613","journal-title":"Front Immunol"},{"issue":"12","key":"12073_CR84","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.3390\/pathogens11121522","volume":"11","author":"M Zhang","year":"2022","unstructured":"Zhang M et al (2022) The Promotional Effect of GW4869 on C. albicans Invasion and Cellular Damage in a Murine Model of Oral Candidiasis. Pathogens 11(12):1522","journal-title":"Pathogens"},{"key":"12073_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2024.100255","author":"K Kulig","year":"2024","unstructured":"Kulig K, Rapala-Kozik M, Karkowska-Kuleta J (2024) Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi. Curr Res Microb Sci. https:\/\/doi.org\/10.1016\/j.crmicr.2024.100255","journal-title":"Curr Res Microb Sci"},{"issue":"1","key":"12073_CR86","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3390\/ijms26010244","volume":"26","author":"R Mart\u00ednez-L\u00f3pez","year":"2024","unstructured":"Mart\u00ednez-L\u00f3pez R et al (2024) From high protection to lethal effect: diverse outcomes of immunization against invasive candidiasis with different Candida albicans extracellular vesicles. Int J Mol Sci 26(1):244","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12073_CR87","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12934-022-01963-6","volume":"21","author":"V Croatti","year":"2022","unstructured":"Croatti V et al (2022) Lactobacilli extracellular vesicles: potential postbiotics to support the vaginal microbiota homeostasis. Microb Cell Fact 21(1):237","journal-title":"Microb Cell Fact"},{"issue":"3","key":"12073_CR88","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/mmi.15130","volume":"122","author":"A Artuyants","year":"2024","unstructured":"Artuyants A et al (2024) Lactobacillus gasseri and Gardnerella vaginalis produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host\u2013Trichomonas vaginalis interactions. Mol Microbiol 122(3):357\u2013371","journal-title":"Mol Microbiol"},{"key":"12073_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2025.07.079","author":"Y Takeda","year":"2025","unstructured":"Takeda Y et al (2025) Gardnerella vaginalis impairs extravillous trophoblast invasion via extracellular matrix-mediated MMP2 downregulation. Placenta. https:\/\/doi.org\/10.1016\/j.placenta.2025.07.079","journal-title":"Placenta"},{"key":"12073_CR90","doi-asserted-by":"publisher","first-page":"893692","DOI":"10.3389\/fmicb.2022.893692","volume":"13","author":"P Rada","year":"2022","unstructured":"Rada P et al (2022) Double-stranded RNA viruses are released from Trichomonas vaginalis inside small extracellular vesicles and modulate the exosomal cargo. Front Microbiol 13:893692","journal-title":"Front Microbiol"},{"key":"12073_CR91","unstructured":"Chan TK (2017) Immune Modulation by Exosomes in Trichomonas vaginalis infection. Harvard University"},{"issue":"1","key":"12073_CR92","doi-asserted-by":"publisher","first-page":"5656","DOI":"10.1038\/s41467-019-13468-9","volume":"10","author":"RA \u00d1ahui Palomino","year":"2019","unstructured":"\u00d1ahui Palomino RA et al (2019) Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues. Nat Commun 10(1):5656","journal-title":"Nat Commun"},{"key":"12073_CR93","doi-asserted-by":"publisher","first-page":"822882","DOI":"10.3389\/fcimb.2021.822882","volume":"11","author":"PE Costantini","year":"2022","unstructured":"Costantini PE et al (2022) Extracellular vesicles generated by gram-positive bacteria protect human tissues ex vivo from HIV-1 infection. Front Cell Infect Microbiol 11:822882","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"12073_CR94","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3390\/fermentation8020074","volume":"8","author":"L-M Wang","year":"2022","unstructured":"Wang L-M et al (2022) Probiotics-derived extracellular vesicles protect oxidative stress against H2O2 induction in placental cells. Fermentation 8(2):74","journal-title":"Fermentation"},{"key":"12073_CR95","doi-asserted-by":"publisher","first-page":"629350","DOI":"10.3389\/fonc.2021.629350","volume":"11","author":"X Chen","year":"2021","unstructured":"Chen X et al (2021) CXCL10 produced by HPV-positive cervical cancer cells stimulates exosomal PDL1 expression by fibroblasts via CXCR3 and JAK-STAT pathways. Front Oncol 11:629350","journal-title":"Front Oncol"},{"key":"12073_CR96","unstructured":"Li W et al Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24. Stem Cells Translational Medicine"},{"issue":"9","key":"12073_CR97","doi-asserted-by":"publisher","first-page":"e00683","DOI":"10.1128\/msystems.00683-25","volume":"10","author":"K Peng","year":"2025","unstructured":"Peng K et al (2025) Lactobacillus crispatus-derived nCEV vesicles promote cutaneous wound healing and inhibit HPV16 infection. Msystems 10(9):e00683\u2013e00625","journal-title":"Msystems"},{"key":"12073_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27019","author":"W Wang","year":"2024","unstructured":"Wang W et al (2024) The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e27019","journal-title":"Heliyon"},{"issue":"26","key":"12073_CR99","doi-asserted-by":"publisher","first-page":"e2508297122","DOI":"10.1073\/pnas.2508297122","volume":"122","author":"JA Kochanowsky","year":"2025","unstructured":"Kochanowsky JA et al (2025) Trichomonas vaginalis extracellular vesicles suppress IFN\u03b5-mediated responses driven by its intracellular bacterial symbiont Mycoplasma hominis. Proc Natl Acad Sci 122(26):e2508297122","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"12073_CR100","doi-asserted-by":"publisher","first-page":"e101629","DOI":"10.1371\/journal.pone.0101629","volume":"9","author":"C Cossetti","year":"2014","unstructured":"Cossetti C et al (2014) Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes. PLoS ONE 9(7):e101629","journal-title":"PLoS ONE"},{"issue":"4","key":"12073_CR101","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/mrd.23121","volume":"86","author":"A Gad","year":"2019","unstructured":"Gad A et al (2019) microRNA expression profile in porcine oocytes with different developmental competence derived from large or small follicles. Mol Reprod Dev 86(4):426\u2013439","journal-title":"Mol Reprod Dev"},{"issue":"2","key":"12073_CR102","first-page":"99","volume":"25","author":"M Javidpou","year":"2020","unstructured":"Javidpou M et al (2020) Mesenchymal stem\/stromal-like cells from diploid and triploid human embryonic stem cells display different gene expression profiles. Iran Biomed J 25(2):99","journal-title":"Iran Biomed J"},{"issue":"1","key":"12073_CR103","doi-asserted-by":"publisher","first-page":"9575","DOI":"10.1038\/s41598-017-08311-4","volume":"7","author":"V Johnson","year":"2017","unstructured":"Johnson V et al (2017) Activated mesenchymal stem cells interact with antibiotics and host innate immune responses to control chronic bacterial infections. Sci Rep 7(1):9575","journal-title":"Sci Rep"},{"key":"12073_CR104","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00404-019-05209-6","volume":"300","author":"W Liao","year":"2019","unstructured":"Liao W et al (2019) Therapeutic effect of human umbilical cord mesenchymal stem cells on tubal factor infertility using a chronic salpingitis murine model. Arch Gynecol Obstet 300:421\u2013429","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"12073_CR105","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/19396368.2024.2306420","volume":"70","author":"M Taravat","year":"2024","unstructured":"Taravat M et al (2024) Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis. Syst Biology Reproductive Med 70(1):3\u201319","journal-title":"Syst Biology Reproductive Med"},{"issue":"4","key":"12073_CR106","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1039\/D2BM01586B","volume":"11","author":"C Zhao","year":"2023","unstructured":"Zhao C et al (2023) An injectable hydrogel scaffold with IL-1\u03b2-activated MSC-derived exosomes for the treatment of endometritis. Biomaterials Sci 11(4):1422\u20131436","journal-title":"Biomaterials Sci"},{"issue":"38","key":"12073_CR107","doi-asserted-by":"publisher","first-page":"9917","DOI":"10.1016\/j.biomaterials.2013.09.002","volume":"34","author":"W Chen","year":"2013","unstructured":"Chen W et al (2013) Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials 34(38):9917\u20139925","journal-title":"Biomaterials"},{"key":"12073_CR108","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303674","author":"Y Liang","year":"2024","unstructured":"Liang Y et al (2024) Incorporation of decidual stromal cells derived exosomes in sodium alginate hydrogel as an innovative therapeutic strategy for advancing endometrial regeneration and reinstating fertility. Adv Healthc Mater. https:\/\/doi.org\/10.1002\/adhm.202303674","journal-title":"Adv Healthc Mater"},{"key":"12073_CR109","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1007\/s43032-019-00112-6","volume":"27","author":"S Zhao","year":"2020","unstructured":"Zhao S et al (2020) Exosomes derived from adipose mesenchymal stem cells restore functional endometrium in a rat model of intrauterine adhesions. Reproductive Sci 27:1266\u20131275","journal-title":"Reproductive Sci"},{"issue":"1","key":"12073_CR110","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s13287-025-04611-z","volume":"16","author":"X Huo","year":"2025","unstructured":"Huo X et al (2025) MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R\/miR-143-5p\/AQP8 axis. Stem Cell Res Ther 16(1):464","journal-title":"Stem Cell Res Ther"},{"key":"12073_CR111","doi-asserted-by":"publisher","first-page":"868734","DOI":"10.3389\/fbioe.2022.868734","volume":"10","author":"Q Zhu","year":"2022","unstructured":"Zhu Q et al (2022) Exosomes derived from CTF1-modified bone marrow stem cells promote endometrial regeneration and restore fertility. Front Bioeng Biotechnol 10:868734","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"12073_CR112","doi-asserted-by":"publisher","first-page":"11974","DOI":"10.1038\/s41598-025-95818-w","volume":"15","author":"K Brennan","year":"2025","unstructured":"Brennan K et al (2025) Menstrual blood serum extracellular vesicles reveal novel molecular biomarkers and potential endotypes of unexplained infertility. Sci Rep 15(1):11974","journal-title":"Sci Rep"},{"issue":"3","key":"12073_CR113","doi-asserted-by":"publisher","first-page":"e70041","DOI":"10.1002\/jex2.70041","volume":"4","author":"S Ducarre","year":"2025","unstructured":"Ducarre S et al (2025) Extracellular Vesicles From Follicular Fluid in Infertile Women: Size, Morphology and miRNA Content Analysis. J Extracell Biology 4(3):e70041","journal-title":"J Extracell Biology"},{"key":"12073_CR114","doi-asserted-by":"publisher","first-page":"100857","DOI":"10.1016\/j.mtbio.2023.100857","volume":"23","author":"X Jin","year":"2023","unstructured":"Jin X et al (2023) ADSC-derived exosomes-coupled decellularized matrix for endometrial regeneration and fertility restoration. Mater Today Bio 23:100857","journal-title":"Mater Today Bio"},{"issue":"12","key":"12073_CR115","doi-asserted-by":"publisher","first-page":"e1008090","DOI":"10.1371\/journal.ppat.1008090","volume":"15","author":"Q Cai","year":"2019","unstructured":"Cai Q et al (2019) Small RNAs and extracellular vesicles: New mechanisms of cross-species communication and innovative tools for disease control. PLoS Pathog 15(12):e1008090","journal-title":"PLoS Pathog"},{"issue":"1","key":"12073_CR116","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1517\/14728222.2014.959495","volume":"19","author":"TP Kegelman","year":"2015","unstructured":"Kegelman TP et al (2015) Targeting tumor invasion: the roles of MDA-9\/Syntenin. Expert Opin Ther Targets 19(1):97\u2013112","journal-title":"Expert Opin Ther Targets"},{"key":"12073_CR117","doi-asserted-by":"publisher","first-page":"785649","DOI":"10.3389\/fmicb.2021.785649","volume":"12","author":"M Zohrabi","year":"2022","unstructured":"Zohrabi M et al (2022) Potential of mesenchymal stem cell-derived exosomes as a novel treatment for female infertility caused by bacterial infections. Front Microbiol 12:785649","journal-title":"Front Microbiol"},{"key":"12073_CR118","doi-asserted-by":"publisher","first-page":"785622","DOI":"10.3389\/fmicb.2021.785622","volume":"12","author":"M Izadi","year":"2022","unstructured":"Izadi M et al (2022) Mesenchymal stem-cell derived exosome therapy as a potential future approach for treatment of male infertility caused by Chlamydia infection. Front Microbiol 12:785622","journal-title":"Front Microbiol"},{"issue":"7","key":"12073_CR119","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41419-022-05037-8","volume":"13","author":"Z Ni","year":"2022","unstructured":"Ni Z et al (2022) Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. Cell Death Dis 13(7):579","journal-title":"Cell Death Dis"},{"issue":"2","key":"12073_CR120","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3390\/biom14020242","volume":"14","author":"HK Kim","year":"2024","unstructured":"Kim HK, Kim TJ (2024) Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency. Biomolecules 14(2):242","journal-title":"Biomolecules"},{"issue":"5","key":"12073_CR121","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s43032-021-00556-9","volume":"29","author":"M Javadi","year":"2022","unstructured":"Javadi M et al (2022) An insight on the role of altered function and expression of exosomes and microRNAs in female reproductive diseases. Reproductive Sci 29(5):1395\u20131407","journal-title":"Reproductive Sci"},{"key":"12073_CR122","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00611","author":"T Rakshit","year":"2024","unstructured":"Rakshit T, Pal S (2024) Extracellular vesicles for drug delivery and theranostics in vivo. JACS Au. https:\/\/doi.org\/10.1021\/jacsau.3c00611","journal-title":"JACS Au"},{"key":"12073_CR123","doi-asserted-by":"publisher","first-page":"122604","DOI":"10.1016\/j.jchromb.2021.122604","volume":"1169","author":"J Stam","year":"2021","unstructured":"Stam J et al (2021) Isolation of extracellular vesicles with combined enrichment methods. J Chromatogr B 1169:122604","journal-title":"J Chromatogr B"},{"issue":"1","key":"12073_CR124","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He C et al (2018) Exosome theranostics: biology and translational medicine. Theranostics 8(1):237","journal-title":"Theranostics"},{"issue":"1","key":"12073_CR125","doi-asserted-by":"publisher","first-page":"1609206","DOI":"10.1080\/20013078.2019.1609206","volume":"8","author":"KW Witwer","year":"2019","unstructured":"Witwer KW et al (2019) Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell vesicles 8(1):1609206","journal-title":"J Extracell vesicles"},{"key":"12073_CR126","doi-asserted-by":"crossref","unstructured":"L\u00f6tvall J et al (2014) Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. Taylor & Francis. p. 26913","DOI":"10.3402\/jev.v3.26913"},{"issue":"13","key":"12073_CR127","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.7150\/thno.40122","volume":"10","author":"S Varderidou-Minasian","year":"2020","unstructured":"Varderidou-Minasian S, Lorenowicz MJ (2020) Mesenchymal stromal\/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics 10(13):5979","journal-title":"Theranostics"},{"issue":"1","key":"12073_CR128","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s13402-024-00969-z","volume":"48","author":"S Peppicelli","year":"2025","unstructured":"Peppicelli S et al (2025) Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells. Cell Oncol 48(1):27\u201341","journal-title":"Cell Oncol"},{"issue":"6","key":"12073_CR129","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tcb.2015.01.004","volume":"25","author":"E Cocucci","year":"2015","unstructured":"Cocucci E, Meldolesi J (2015) Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol 25(6):364\u2013372","journal-title":"Trends Cell Biol"},{"issue":"5","key":"12073_CR130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00604-025-07147-4","volume":"192","author":"S Escudero-Cernuda","year":"2025","unstructured":"Escudero-Cernuda S et al (2025) Limitations and challenges in the characterization of extracellular vesicles from stem cells and serum. Microchim Acta 192(5):1\u201312","journal-title":"Microchim Acta"},{"key":"12073_CR131","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c00443","author":"S Zaffar","year":"2025","unstructured":"Zaffar S et al (2025) Improved diabetic wound healing via flower extracellular vesicles and carbon-dot-infused alginate-polyethylenimine antibacterial hydrogel. ACS Biomater Sci Eng. https:\/\/doi.org\/10.1021\/acsbiomaterials.5c00443","journal-title":"ACS Biomater Sci Eng"},{"issue":"18","key":"12073_CR132","doi-asserted-by":"publisher","first-page":"e70062","DOI":"10.1096\/fj.202401346R","volume":"38","author":"YQ Fang","year":"2024","unstructured":"Fang YQ et al (2024) Brown adipose tissue-derived exosomes improve polycystic ovary syndrome in mice via STAT3\/GPX4 signaling pathway. FASEB J 38(18):e70062","journal-title":"FASEB J"},{"issue":"10","key":"12073_CR133","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.5966\/sctm.2015-0367","volume":"5","author":"S Fang","year":"2016","unstructured":"Fang S et al (2016) Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor-\u03b2\/SMAD2 pathway during wound healing. Stem cells translational Med 5(10):1425\u20131439","journal-title":"Stem cells translational Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12073-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12073-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12073-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:02:24Z","timestamp":1780740144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12073-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":133,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12073"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12073-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"11 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Ethics and Consent to Participate Declarations"}}],"article-number":"900"}}