{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:56:13Z","timestamp":1781877373334,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12117-x","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:27:19Z","timestamp":1781875639000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of methicillin-resistant coagulase-negative staphylococci and their antibiotic resistance profile in Zagazig University intensive care units"],"prefix":"10.1007","volume":"53","author":[{"given":"Hend M.","family":"Elarini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Gaafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessma H.","family":"Gandor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid M A.","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya M.","family":"Bedawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"12117_CR1","doi-asserted-by":"publisher","unstructured":"Paranthaman K, Wilson A, Verlander N et al (2023) Trends in coagulase-negative staphylococci (CoNS), England, 2010\u20132021. Access Microbiol 5(6). https:\/\/doi.org\/10.1099\/acmi.0.000491.v3. acmi000491.v3","DOI":"10.1099\/acmi.0.000491.v3"},{"key":"12117_CR2","doi-asserted-by":"publisher","unstructured":"Chaj\u0119cka-Wierzchowska W, Gajewska J, Zadernowska A, Randazzo CL, Caggia C (2023) A comprehensive study on antibiotic resistance among coagulase-negative staphylococci (CoNS) strains isolated from ready-to-eat food served in bars and restaurants. Foods 12(3):514, 514. https:\/\/doi.org\/10.3390\/foods12030514","DOI":"10.3390\/foods12030514"},{"issue":"1","key":"12117_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12941-020-00367-x","volume":"19","author":"M Michalik","year":"2020","unstructured":"Michalik M, Samet A, Podbielska-Kubera A, Savini V, Mi\u0119dzobrodzki J, Kosecka-Strojek M (2020) Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review. Ann Clin Microbiol Antimicrob 19(1):26. https:\/\/doi.org\/10.1186\/s12941-020-00367-x","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"2","key":"12117_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.18231\/j.ijmmtd.2021.022","volume":"7","author":"SS Ahirwar","year":"2021","unstructured":"Ahirwar SS, Jatav P, Kushwaha K (2021) Distribution of MR-CoNS in the clinical staffs of tertiary care hospital. IP International Journal of Medical Microbiology and Tropical Diseases 7(2):100\u2013102. https:\/\/doi.org\/10.18231\/j.ijmmtd.2021.022","journal-title":"IP International Journal of Medical Microbiology and Tropical Diseases"},{"issue":"6","key":"12117_CR5","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1080\/1040841X.2023.2274841","volume":"50","author":"M Wolska-G\u0119barzewska","year":"2024","unstructured":"Wolska-G\u0119barzewska M, Mi\u0119dzobrodzki J, Kosecka-Strojek M (2024) Current types of staphylococcal cassette chromosome mec (SCCmec) in clinically relevant coagulase-negative staphylococcal (CoNS) species. Crit Rev Microbiol 50(6):1020\u20131036. https:\/\/doi.org\/10.1080\/1040841X.2023.2274841","journal-title":"Crit Rev Microbiol"},{"key":"12117_CR6","doi-asserted-by":"publisher","unstructured":"Abdelwahab MA, Amer WH, Elsharawy D, Elkolaly RM, Helal RAEF, El Malla DA, Elfeky YG, Bedair HA, Amer RS, Abd-Elmonsef ME et al (2023) Phenotypic and genotypic characterization of methicillin resistance in staphylococci isolated from an Egyptian University Hospital. Pathogens 12(4):556, 556. https:\/\/doi.org\/10.3390\/pathogens12040556","DOI":"10.3390\/pathogens12040556"},{"issue":"8","key":"12117_CR7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S1473-3099(11)70126-8","volume":"11","author":"L Garc\u00eda-\u00c1lvarez","year":"2011","unstructured":"Garc\u00eda-\u00c1lvarez L, Holden MT, Lindsay H et al (2011) Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect Dis 11(8):595\u2013603. https:\/\/doi.org\/10.1016\/S1473-3099(11)70126-8","journal-title":"Lancet Infect Dis"},{"key":"12117_CR8","doi-asserted-by":"publisher","unstructured":"Milheiri\u00e7o C, de Lencastre H, Tomasz A (2017) Full-genome sequencing identifies in the genetic background several determinants that modulate the resistance phenotype in methicillin-resistant Staphylococcus aureus strains carrying the novel mecC gene. Antimicrob Agents Chemother 61(3):e02500-16, e02500-16. https:\/\/doi.org\/10.1128\/AAC.02500-16","DOI":"10.1128\/AAC.02500-16"},{"key":"12117_CR9","unstructured":"Forbes BA, Sahm DF, Weissfeld AS (2007) Bailey and Scott\u2019s Diagnostic Microbiology. 12th Edition, Mosby Elsevier, St Louis, Missouri, pp 288\u2013302"},{"issue":"5","key":"12117_CR10","doi-asserted-by":"publisher","first-page":"e00106","DOI":"10.1128\/jcm.00106-25","volume":"63","author":"RM Humphries","year":"2025","unstructured":"Humphries RM, Simner PJ (2025) Major updates to FDA-recognized clinical and laboratory standards institute breakpoints are a win for the fight against antimicrobial resistance. J Clin Microbiol 63(5):e00106\u2013e00125","journal-title":"J Clin Microbiol"},{"issue":"4","key":"12117_CR11","first-page":"126","volume":"4","author":"O Ezeokoli","year":"2016","unstructured":"Ezeokoli O, Adamu L, Ezeamaramu F, Ovioma G, Oladele J, Fowora M, Ugo-Ijeh M, Iyile J (2016) Antibiotics susceptibility pattern and plasmid profile of bacteria isolated from public motorcycle helmets. Am J Microbiol Res 4(4):126\u2013131. https:\/\/pubs.sciepub.com\/ajmr\/4\/4\/4","journal-title":"Am J Microbiol Res"},{"key":"12117_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4172\/1989-8436.100071","volume":"9","author":"AA Rania","year":"2017","unstructured":"Rania AA, Nsreen MK, Rasha H, Mona MA (2017) Evaluation for the novel mecC methicillin resistance among methicillin resistant staphylococcal isolates in two Egyptian university hospitals. Arch Clin Microbiol 9:71. https:\/\/doi.org\/10.4172\/1989-8436.100071","journal-title":"Arch Clin Microbiol"},{"issue":"9","key":"12117_CR13","doi-asserted-by":"publisher","first-page":"e24360","DOI":"10.1371\/journal.pone.0024360","volume":"6","author":"C Cuny","year":"2011","unstructured":"Cuny C, Layer F, Strommenger B, Witte W (2011) Rare occurrence of methicillin-resistant Staphylococcus aureus CC130 with a novel mecA homologue in humans in Germany. PLoS ONE 6(9):e24360. https:\/\/doi.org\/10.1371\/journal.pone.0024360","journal-title":"PLoS ONE"},{"issue":"4","key":"12117_CR14","doi-asserted-by":"publisher","first-page":"e0249823","DOI":"10.1371\/journal.pone.0249823","volume":"16","author":"D Ashagrie","year":"2021","unstructured":"Ashagrie D, Genet C, Abera B (2021) Vancomycin-resistant enterococci and coagulase-negative staphylococci prevalence among patients attending at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia. PLoS ONE 16(4):e0249823. https:\/\/doi.org\/10.1371\/journal.pone.0249823","journal-title":"PLoS ONE"},{"issue":"1","key":"12117_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s42506-020-00065-8","volume":"96","author":"NAE Fahim","year":"2021","unstructured":"Fahim NAE (2021) Prevalence and antimicrobial susceptibility profile of multidrug-resistant bacteria among intensive care units patients at Ain Shams University Hospitals in Egypt\u2014a retrospective study. J Egypt Public Health Assoc 96(1):7. https:\/\/doi.org\/10.1186\/s42506-020-00065-8","journal-title":"J Egypt Public Health Assoc"},{"issue":"1","key":"12117_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1177\/0049475520962740","volume":"51","author":"EF Ahmed","year":"2021","unstructured":"Ahmed EF, Gad GF, Soliman WE, El-Asady RS, Hasaneen AM, Abdelwahab SF (2021) Prevalence of methicillin-resistant coagulase-negative staphylococci among Egyptian patients after surgical interventions. Trop Doct 51(1):40\u201344. https:\/\/doi.org\/10.1177\/0049475520962740","journal-title":"Trop Doct"},{"issue":"4","key":"12117_CR17","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.21608\/MID.2023.233589.1608","volume":"4","author":"HI Abd El-Hady","year":"2023","unstructured":"Abd El-Hady HI, Abbass AM, Amer M, Abdallah ES, Abdelhadi AA (2023) Linezolid resistance in coagulase negative Staphylococci isolates and the related genes in intensive care unit patients in a University Hospital in Egypt. Microbes Infect Dis 4(4):1232\u20131245. https:\/\/doi.org\/10.21608\/MID.2023.233589.1608","journal-title":"Microbes Infect Dis"},{"key":"12117_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/1756-0500-3-260","volume":"3","author":"A Oliveira","year":"2010","unstructured":"Oliveira A, Cunha MdeL (2010) Comparison of methods for the detection of biofilm production in coagulase-negative staphylococci. BMC BMC Res Notes 3:260. https:\/\/doi.org\/10.1186\/1756-0500-3-260","journal-title":"BMC BMC Res Notes"},{"key":"12117_CR19","doi-asserted-by":"publisher","first-page":"607","DOI":"10.2147\/IDR.S159764","volume":"11","author":"LB Shrestha","year":"2018","unstructured":"Shrestha LB, Bhattarai NR, Khanal B (2018) Comparative evaluation of methods for the detection of biofilm formation in coagulase-negative staphylococci and correlation with antibiogram. Infect Drug Resist 11:607\u2013613. https:\/\/doi.org\/10.2147\/IDR.S159764","journal-title":"Infect Drug Resist"},{"key":"12117_CR20","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.2147\/IDR.S172144","volume":"11","author":"AD Khosravi","year":"2018","unstructured":"Khosravi AD, Roointan M, Abbasi Montazeri E, Aslani S, Hashemzadeh M, Taheri Soodejani M (2018) Application of tuf gene sequence analysis for the identification of species of coagulase-negative staphylococci in clinical samples and evaluation of their antimicrobial resistance pattern. Infect Drug Resist 11:1275\u20131282. https:\/\/doi.org\/10.2147\/IDR.S172144","journal-title":"Infect Drug Resist"},{"issue":"4","key":"12117_CR21","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1128\/CMR.00109-13","volume":"27","author":"K Becker","year":"2014","unstructured":"Becker K, Heilmann C, Peters G (2014) Coagulase-negative staphylococci. Clin Microbiol Rev 27(4):870\u2013926. https:\/\/doi.org\/10.1128\/CMR.00109-13","journal-title":"Clin Microbiol Rev"},{"key":"12117_CR22","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2147\/IDR.S151271","volume":"11","author":"E De Vecchi","year":"2018","unstructured":"De Vecchi E, George DA, Roman\u00f2 CL, Pregliasco FE, Mattina R, Drago L (2018) Antibiotic sensitivities of coagulase-negative staphylococci and Staphylococcus aureus in hip and knee periprosthetic joint infections: does this differ if patients meet the International Consensus Meeting Criteria? Infect Drug Resist 11:539\u2013546. https:\/\/doi.org\/10.2147\/IDR.S151271","journal-title":"Infect Drug Resist"},{"issue":"Suppl 1","key":"12117_CR23","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/j.mjafi.2016.07.009","volume":"72","author":"L Singh","year":"2016","unstructured":"Singh L, Cariappa MP, Das NK (2016) Drug sensitivity pattern of various Staphylococcus species isolated at a tertiary care hospital. Med J Armed Forces India 72(Suppl 1):S62\u2013S66. https:\/\/doi.org\/10.1016\/j.mjafi.2016.07.009","journal-title":"Med J Armed Forces India"},{"issue":"4","key":"12117_CR24","doi-asserted-by":"publisher","first-page":"500","DOI":"10.4103\/0255-0857.195374","volume":"34","author":"S Singh","year":"2016","unstructured":"Singh S, Dhawan B, Kapil A, Kabra SK, Suri A, Sreenivas V, Das BK (2016) Coagulase-negative staphylococci causing blood stream infection at an Indian tertiary care hospital: prevalence, antimicrobial resistance and molecular characterisation. Indian J Med Microbiol 34(4):500\u2013505. https:\/\/doi.org\/10.4103\/0255-0857.195374","journal-title":"Indian J Med Microbiol"},{"issue":"5","key":"12117_CR25","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200847","volume":"40","author":"E Abbasi Montazeri","year":"2020","unstructured":"Abbasi Montazeri E, Seyed-Mohammadi S, Asarehzadegan Dezfuli A, Khosravi AD, Dastoorpoor M, Roointan M, Saki M (2020) Investigation of SCCmec types I-IV in clinical isolates of methicillin-resistant coagulase-negative staphylococci in Ahvaz, Southwest Iran. Biosci Rep 40(5):BSR20200847. https:\/\/doi.org\/10.1042\/BSR20200847","journal-title":"Biosci Rep"},{"issue":"9","key":"12117_CR26","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1128\/AAC.00279-12","volume":"56","author":"RE Mendes","year":"2012","unstructured":"Mendes RE, Deshpande LM, Costello AJ, Farrell DJ (2012) Molecular epidemiology of Staphylococcus epidermidis clinical isolates from US hospitals. Antimicrobial agents and chemotherapy 56(9):4656\u20134661. https:\/\/doi.org\/10.1128\/AAC.00279-12","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"Suppl 1","key":"12117_CR27","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1016\/j.mjafi.2016.03.007","volume":"72","author":"P Bhatt","year":"2016","unstructured":"Bhatt P, Tandel K, Singh A, Kumar M, Grover N, Sahni AK (2016) Prevalence and molecular characterization of methicillin resistance among coagulase-negative staphylococci at a tertiary care center. Med J Armed Forces India 72(Suppl 1):S54\u2013S58. https:\/\/doi.org\/10.1016\/j.mjafi.2016.03.007","journal-title":"Med J Armed Forces India"},{"issue":"4","key":"12117_CR28","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3329\/jhpn.v28i4.6037","volume":"28","author":"AI Adeyemi","year":"2010","unstructured":"Adeyemi AI, Sulaiman AA, Solomon BB, Chinedu OA, Victor IA (2010) Bacterial bloodstream infections in HIV-infected adults attending a Lagos teaching hospital. J Health Popul Nutr 28(4):318\u2013326. https:\/\/doi.org\/10.3329\/jhpn.v28i4.6037","journal-title":"J Health Popul Nutr"},{"key":"12117_CR29","doi-asserted-by":"publisher","unstructured":"Asante J, Hetsa BA, Amoako DG, Abia ALK, Bester LA, Essack SY (2021) Multidrug-resistant coagulase-negative staphylococci isolated from bloodstream in the uMgungundlovu District of KwaZulu-Natal Province in South Africa: emerging pathogens. Antibiotics (Basel) 10(2):198, 198. https:\/\/doi.org\/10.3390\/antibiotics10020198","DOI":"10.3390\/antibiotics10020198"},{"key":"12117_CR30","doi-asserted-by":"publisher","unstructured":"Mashaly GE, El-Mahdy RH (2017) Vancomycin heteroresistance in coagulase negative Staphylococcus blood stream infections from patients of intensive care units in Mansoura University Hospitals, Egypt. Ann Clin Microbiol Antimicrob 16(1):63, 63. https:\/\/doi.org\/10.1186\/s12941-017-0238-5","DOI":"10.1186\/s12941-017-0238-5"},{"key":"12117_CR31","doi-asserted-by":"publisher","unstructured":"Shrestha LB, Bhattarai NR, Rai K, Khanal B (2020) Antibiotic resistance and mecA gene characterization of coagulase-negative Staphylococci isolated from clinical samples in Nepal. Infect Drug Resist 13:3163\u20133169. https:\/\/doi.org\/10.2147\/IDR.S274163","DOI":"10.2147\/IDR.S274163"},{"issue":"2","key":"12117_CR32","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bjid.2020.01.003","volume":"24","author":"VC Pereira","year":"2020","unstructured":"Pereira VC, Romero LC, Pinheiro-Hubinger L, Oliveira A, Martins KB (2020) Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital. Braz J Infect Dis 24(2):160\u2013169. https:\/\/doi.org\/10.1016\/j.bjid.2020.01.003","journal-title":"Braz J Infect Dis"},{"issue":"6","key":"12117_CR33","first-page":"294","volume":"7","author":"IA Al Tayyar","year":"2015","unstructured":"Al Tayyar IA, Al-Zoubi MS, Hussein E, Khudairat S, Sarosiekf K (2015) Prevalence and antimicrobial susceptibility pattern of coagulase-negative staphylococci (CoNS) isolated from clinical specimens in Northern of Jordan. Iran J Microbiol 7(6):294\u2013301","journal-title":"Iran J Microbiol"},{"issue":"8","key":"12117_CR34","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1089\/mdr.2019.0381","volume":"26","author":"J Asante","year":"2020","unstructured":"Asante J, Amoako DG, Abia ALK, Somboro AM, Govinden U, Bester LA, Essack SY (2020) Review of clinically and epidemiologically relevant coagulase-negative staphylococci in Africa. Microb Drug Resist 26(8):951\u2013970. https:\/\/doi.org\/10.1089\/mdr.2019.0381","journal-title":"Microb Drug Resist"},{"key":"12117_CR35","doi-asserted-by":"publisher","unstructured":"Lozano C, Fern\u00e1ndez-Fern\u00e1ndez R, Ruiz-Ripa L, G\u00f3mez P, Zarazaga M, Torres C (2020) Human mecC-Carrying MRSA: Clinical Implications and Risk Factors. Microorganisms 8(10):1615, 1615. https:\/\/doi.org\/10.3390\/microorganisms8101615","DOI":"10.3390\/microorganisms8101615"},{"issue":"1","key":"12117_CR36","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/bies.201200112","volume":"35","author":"M Otto","year":"2013","unstructured":"Otto M (2013) Coagulase\u2010negative staphylococci as reservoirs of genes facilitating MRSA infection. BioEssays 35(1):4\u201311. https:\/\/doi.org\/10.1002\/bies.201200112","journal-title":"BioEssays"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12117-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12117-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12117-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:27:22Z","timestamp":1781875642000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12117-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12117"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12117-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study received approval from the Institutional Review Board of the Faculty of Medicine, Zagazig University (ZU-IRB#11168-17-10-2023) in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"962"}}